format-version: 1.0
date: 04:03:2011 12:51
saved-by: yamamotosatoko
auto-generated-by: OBO-Edit 1.002
default-namespace: molecule_role
remark: version: 2.24
remark: cvs version: 1.9

[Term]
id: IMR:0000001
name: MoleculeRole

[Term]
id: IMR:0000002
name: ligand
def: "Binding to a specific receptor protein and activating intracellular signaling cascades that alter the behavior of the cell." [ISBN:0815340729]
xref_analog: GO:0005102
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000003
name: Wnt
xref_analog: GO:0005110
is_a: IMR:0000002 ! ligand

[Term]
id: IMR:0000004
name: hedgehog
exact_synonym: "Hh" []
xref_analog: GO:0005113
is_a: IMR:0000002 ! ligand

[Term]
id: IMR:0000005
name: Shh
exact_synonym: "HHG-1" []
exact_synonym: "Sonic hedgehog" []
is_a: IMR:0000004 ! hedgehog

[Term]
id: IMR:0000006
name: cytokine
def: "Extracellular signal protein or peptide that acts as a local mediator in cell-cell communication." [ISBN:0815340729]
xref_analog: GO:0005125
is_a: IMR:0000002 ! ligand

[Term]
id: IMR:0000007
name: Interleukin
exact_synonym: "IL" []
is_a: IMR:0000006 ! cytokine

[Term]
id: IMR:0000008
name: IL-2
exact_synonym: "Interleukin-2" []
exact_synonym: "TCGF" []
xref_analog: GO:0005134
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000009
name: IL-5
exact_synonym: "interleukin-5" []
xref_analog: GO:0005137
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000010
name: IL-6
exact_synonym: "interleukin-6" []
xref_analog: GO:0005138
is_a: IMR:0000007 ! Interleukin
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000011
name: IL-1
exact_synonym: "interleukin-1" []
xref_analog: GO:0005149
is_a: IMR:0000007 ! Interleukin
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000012
name: IL-3
exact_synonym: "interleukin-3" []
xref_analog: GO:0005135
is_a: IMR:0000007 ! Interleukin
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000013
name: IL-11
exact_synonym: "interleukin-11" []
xref_analog: GO:0005142
is_a: IMR:0000007 ! Interleukin
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000014
name: hematopoietic factor
is_a: IMR:0000006 ! cytokine

[Term]
id: IMR:0000015
name: TPO
exact_synonym: "thrombopoietin" []
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000016
name: EPO
exact_synonym: "erythropoietin" []
xref_analog: GO:0005128
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000017
name: G-CSF
exact_synonym: "granulocyte colony-stimulating factor" []
xref_analog: GO:0005130
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000018
name: GM-CSF
exact_synonym: "granulocyte-macrophage colony-stimulating factor" []
xref_analog: GO:0005129
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000019
name: LIF
exact_synonym: "leukemia inhibitory factor" []
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000020
name: SCF
exact_synonym: "stem cell factor" []
xref_analog: GO:0005173
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000021
name: TNF superfamily
xref_analog: GO:0005164
xref_analog: IPR:006052
is_a: IMR:0000006 ! cytokine

[Term]
id: IMR:0000022
name: FasL
exact_synonym: "CD178 antigen" []
exact_synonym: "CD95L" []
exact_synonym: "Fas ligand" []
exact_synonym: "FasL" []
exact_synonym: "Tumor necrosis factor ligand superfamily member 6" []
is_a: IMR:0000021 ! TNF superfamily

[Term]
id: IMR:0000023
name: CD40L
exact_synonym: "CD154" []
exact_synonym: "CD40 ligand" []
exact_synonym: "gp39" []
xref_analog: GO:0005174
is_a: IMR:0000021 ! TNF superfamily

[Term]
id: IMR:0000024
name: TNF family
comment: This term was made obsolete. To update annotations, consider the term 'IMR0000021:TNF superfamily'.
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0000025
name: TNF alpha
exact_synonym: "TNF" []
exact_synonym: "tumor necrosis factor alpha" []
is_a: IMR:0000021 ! TNF superfamily

[Term]
id: IMR:0000026
name: LT alpha
exact_synonym: "lymphotoxin" []
exact_synonym: "lymphotoxin alpha" []
exact_synonym: "TNF beta" []
is_a: IMR:0000021 ! TNF superfamily

[Term]
id: IMR:0000027
name: Interferon
exact_synonym: "IFN" []
is_a: IMR:0000006 ! cytokine

[Term]
id: IMR:0000028
name: IFN type I
exact_synonym: "type I Interferon" []
xref_analog: GO:0005132
is_a: IMR:0000027 ! Interferon

[Term]
id: IMR:0000029
name: IFN type II
exact_synonym: "type II Interferon" []
xref_analog: GO:0005133
is_a: IMR:0000027 ! Interferon

[Term]
id: IMR:0000030
name: growth factor
def: "Extracellular polypeptide signal molecule that can stimulate a cell grow or proliferate. Examples are EGF and PDGF. Most growth factors also have other actions." [ISBN:0815340729]
exact_synonym: "Growth Substance" []
xref_analog: GO:0008083
is_a: IMR:0000002 ! ligand

[Term]
id: IMR:0000031
name: VEGF
exact_synonym: "vascular endothelial growth factor" []
xref_analog: GO:0005172
is_a: IMR:0000030 ! growth factor

[Term]
id: IMR:0000032
name: PDGF
exact_synonym: "platelet derived growth factor" []
xref_analog: GO:0005161
is_a: IMR:0000030 ! growth factor

[Term]
id: IMR:0000033
name: HGF
exact_synonym: "hepatocyte growth factor" []
exact_synonym: "scatter factor" []
xref_analog: GO:0005171
is_a: IMR:0000030 ! growth factor

[Term]
id: IMR:0000034
name: NGF family
exact_synonym: "nerve growth factor family" []
exact_synonym: "neurotrophin" []
xref_analog: GO:0005165
is_a: IMR:0000030 ! growth factor

[Term]
id: IMR:0000035
name: type I cytokeratin
exact_synonym: "acidic cytokeratin" []
is_a: IMR:0000202 ! keratin

[Term]
id: IMR:0000036
name: TGF-beta superfamily
def: "The TGF-beta superfamily of growth factors regulate many cellular functions, which includes TGF-betas, activins and inhibins, nodal, BMPs and GDFs. TGF-beta/BMP-like proteins are found in various species, including Xenopus, C.elegans and D.melanogaster." [PubMed:12485160, PubMed:18000526, PubMed:9759503]
exact_synonym: "transforming growth factor beta superfamily" []
xref_analog: GO:0005160
is_a: IMR:0000030 ! growth factor

[Term]
id: IMR:0000037
name: inhibin
xref_analog: GO:0016916
is_a: IMR:0000036 ! TGF-beta superfamily

[Term]
id: IMR:0000038
name: dorsalin-1
comment: This term was made obsolete. To update annotations, consider the term 'IMR_0000036:TGF-beta superfamily'.
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0000039
name: activin
xref_analog: GO:0016915
is_a: IMR:0000036 ! TGF-beta superfamily

[Term]
id: IMR:0000040
name: BMP family
def: "BMPs belong to the TGF-beta superfamily. BMP-like molecules have been identified in various species including D.melanogaster (Dpp, Gbb/60A and Scw) and C.elegans." [PubMed:15871923, PubMed:9720756, PubMed:9759503]
exact_synonym: "Bone morphogenetic protein family" []
is_a: IMR:0000036 ! TGF-beta superfamily

[Term]
id: IMR:0000041
name: TGF-beta family
xref_analog: GO:0005160
is_a: IMR:0000036 ! TGF-beta superfamily

[Term]
id: IMR:0000042
name: TGF-beta1
exact_synonym: "transforming growth factor-beta 1" []
xref_analog: GO:0005160
is_a: IMR:0000041 ! TGF-beta family

[Term]
id: IMR:0000043
name: TGF-beta2
exact_synonym: "transforming growth factor-beta 2" []
xref_analog: GO:0005160
is_a: IMR:0000041 ! TGF-beta family

[Term]
id: IMR:0000044
name: TGF-beta3
exact_synonym: "transforming growth factor-beta 3" []
xref_analog: GO:0005160
is_a: IMR:0000041 ! TGF-beta family

[Term]
id: IMR:0000045
name: GDNF
exact_synonym: "Glial cell line-derived neurotrophic factor" []
xref_analog: GO:0005160
is_a: IMR:0000030 ! growth factor

[Term]
id: IMR:0000046
name: Nodal family
is_a: IMR:0000036 ! TGF-beta superfamily

[Term]
id: IMR:0000047
name: EGF family
exact_synonym: "epidermal growth factor family" []
is_a: IMR:0000030 ! growth factor

[Term]
id: IMR:0000048
name: neuregulin
exact_synonym: "NRG" []
is_a: IMR:0000047 ! EGF family

[Term]
id: IMR:0000049
name: FGF
exact_synonym: "Fibroblast growth factor" []
exact_synonym: "HBGF" []
exact_synonym: "Heparin-binding growth factor" []
xref_analog: GO:0005104
is_a: IMR:0000030 ! growth factor

[Term]
id: IMR:0000050
name: type II cytokeratin
exact_synonym: "neutral to basic cytokeratin" []
is_a: IMR:0000202 ! keratin

[Term]
id: IMR:0000051
name: leptin
is_a: IMR:0100046 ! peptide hormone

[Term]
id: IMR:0000052
name: insulin
alt_id: IMR:0010309
alt_id: IMR:0011543
alt_id: IMR:0011922
def: "A protein hormone secreted by beta cells of the pancreas. Insulin plays a major role in the regulation of glucose metabolism, generally promoting the cellular utilization of glucose. It is also an important regulator of protein and lipid metabolism. Insulin is used as a drug to control insulin-dependent diabetes mellitus." [MeSH:D007328]
exact_synonym: "Humulin" []
exact_synonym: "insulin A chain" []
exact_synonym: "insulin B chain" []
exact_synonym: "insulin fragments" []
exact_synonym: "Insulin precursor" []
xref_analog: GO:0016088
xref_analog: KEGG:C00723
xref_analog: MeSH:D007328
is_a: IMR:0002835 ! insulin family
is_a: IMR:0100076 ! pancreatic hormone

[Term]
id: IMR:0000053
name: cytokeratin 1
is_a: IMR:0000050 ! type II cytokeratin

[Term]
id: IMR:0000054
name: receptor
def: "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GO:0004872]
xref_analog: GO:0004872
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000055
name: Frizzled
exact_synonym: "Fz" []
xref_analog: GO:0042813
is_a: IMR:0100801 ! FZ/SMO family

[Term]
id: IMR:0000056
name: TNFR family
exact_synonym: "tumor necrosis factor receptor family" []
xref_analog: GO:0005027
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000057
name: CD40
xref_analog: GO:0005028
is_a: IMR:0000056 ! TNFR family

[Term]
id: IMR:0000058
name: FasR
exact_synonym: "Apo-1" []
exact_synonym: "CD95" []
exact_synonym: "Fas receptor" []
is_a: IMR:0000056 ! TNFR family

[Term]
id: IMR:0000059
name: p75NTR
exact_synonym: "neurotrophin receptor" []
xref_analog: GO:0005030
is_a: IMR:0000056 ! TNFR family
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000060
name: TNFR1
exact_synonym: "tumor necrosis factor receptor, type I" []
xref_analog: GO:0005032
is_a: IMR:0100674 ! TNF alpha receptor

[Term]
id: IMR:0000061
name: TNFR2
exact_synonym: "tumor necrosis factor receptor, type II" []
xref_analog: GO:0005033
is_a: IMR:0100674 ! TNF alpha receptor

[Term]
id: IMR:0000062
name: receptor protein-tyrosine phosphatase
exact_synonym: "receptor-like protein tyrosine phosphatase" []
exact_synonym: "RPTP" []
xref_analog: GO:0005001
is_a: IMR:0000273 ! protein tyrosine phosphatase
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000063
name: receptor tyrosine kinase
exact_synonym: "transmembrane receptor tyrosine kinase" []
xref_analog: GO:0004714
is_a: IMR:0000210 ! protein tyrosine kinase
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000064
name: Flt
exact_synonym: "fms-like tyrosine kinase" []
exact_synonym: "vascular endothelial growth factor receptor" []
exact_synonym: "VEGF receptor" []
xref_analog: GO:0005021
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000065
name: Flt-1
exact_synonym: "Fms-like tyrosine kinase 1" []
exact_synonym: "Vascular endothelial growth factor receptor 1" []
exact_synonym: "VEGFR-1" []
is_a: IMR:0000064 ! Flt

[Term]
id: IMR:0000066
name: KDR
exact_synonym: "Flk-1" []
exact_synonym: "Kinase insert domain receptor" []
exact_synonym: "Vascular endothelial growth factor receptor 2" []
exact_synonym: "VEGFR-2" []
is_a: IMR:0000064 ! Flt

[Term]
id: IMR:0000067
name: Flt-4
exact_synonym: "Vascular endothelial growth factor receptor 3" []
exact_synonym: "VEGFR-3" []
is_a: IMR:0000064 ! Flt

[Term]
id: IMR:0000068
name: PDGF receptor
exact_synonym: "platelet derived growth factor receptor" []
xref_analog: GO:0005017
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000069
name: alpha PDGF receptor
exact_synonym: "alpha platelet derived growth factor receptor" []
xref_analog: GO:0005018
is_a: IMR:0000068 ! PDGF receptor

[Term]
id: IMR:0000070
name: beta PDGF receptor
exact_synonym: "beta platelet derived growth factor receptor" []
xref_analog: GO:0005019
is_a: IMR:0000068 ! PDGF receptor

[Term]
id: IMR:0000071
name: Met
exact_synonym: "hepatocyte growth factor receptor" []
exact_synonym: "HGF receptor" []
xref_analog: GO:0005008
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000072
name: TRK
exact_synonym: "nerve growth factor receptor" []
exact_synonym: "NGF receptor" []
exact_synonym: "tropomyosin-receptor-kinase" []
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000073
name: 7LESS_DROME
exact_synonym: "7LES" [FlyBase:FBgn0003366]
exact_synonym: "7less" [FlyBase:FBgn0003366]
exact_synonym: "CG18085" [FlyBase:FBgn0003366]
exact_synonym: "CT3980" [FlyBase:FBgn0003366]
exact_synonym: "DmHD-265" [FlyBase:FBgn0003366]
exact_synonym: "DROSEV" [FlyBase:FBgn0003366]
exact_synonym: "DROSEV1" [FlyBase:FBgn0003366]
exact_synonym: "EC 2.7.10.1" [UniProt:P13368]
exact_synonym: "HD-265" [FlyBase:FBgn0003366, UniProt:P13368]
exact_synonym: "Protein sevenless" [UniProt:P13368]
exact_synonym: "sev" [FlyBase:FBgn0003366, UniProt:P13368]
exact_synonym: "Sev" [FlyBase:FBgn0003366]
exact_synonym: "sev(AC)[[14]]" [FlyBase:FBgn0003366]
exact_synonym: "sevenless" [FlyBase:FBgn0003366]
xref_analog: UniProt:P13368
relationship: sequence_of IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000074
name: Kit
exact_synonym: "c-Kit" []
exact_synonym: "mast/stem cell growth factor receptor" []
xref_analog: GO:0005020
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000075
name: insulin receptor family
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000076
name: ALK
exact_synonym: "anaplastic lymphoma kinase" []
is_a: IMR:0000075 ! insulin receptor family

[Term]
id: IMR:0000077
name: LTK
exact_synonym: "leukocyte tyrosine kinase" []
is_a: IMR:0000075 ! insulin receptor family

[Term]
id: IMR:0000078
name: insulin receptor
alt_id: IMR:0010308
alt_id: IMR:0011304
alt_id: IMR:0011542
exact_synonym: "CD220 antigen" []
exact_synonym: "insulin receptor alpha subunit" []
exact_synonym: "insulin receptor beta subunit" []
exact_synonym: "insulin receptor precursor" []
exact_synonym: "IR" []
xref_analog: GO:0005009
is_a: IMR:0000075 ! insulin receptor family

[Term]
id: IMR:0000079
name: RET
exact_synonym: "glial cell line-derived neurotrophic factor receptor" []
xref_analog: GO:0016167
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000080
name: FGFR
def: "The vertebrate Fgfr gene family consists of four highly related genes, Fgfr1-4." [PubMed:15689573]
exact_synonym: "fibroblast growth factor receptor" []
xref_analog: GO:0005007
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000081
name: EGFR
exact_synonym: "epidermal growth factor receptor" []
xref_analog: GO:0005006
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000082
name: ligand-gated ion channel
exact_synonym: "receptor-channel" []
xref_analog: GO:0015276
is_a: IMR:0000481 ! ion channel

[Term]
id: IMR:0000083
name: NMDAR
exact_synonym: "N-methyl-D-aspartate receptor" []
xref_analog: GO:0004972
is_a: IMR:0000498 ! cation channel
is_a: IMR:0000747 ! extracellular ligand-gated ion channel

[Term]
id: IMR:0000084
name: IP3 receptor
exact_synonym: "inositol-1,4,5-triphosphate receptor" []
exact_synonym: "IP3R" []
xref_analog: GO:0008095
is_a: IMR:0000499 ! calcium channel
is_a: IMR:0000746 ! intracellular ligand-gated ion channel

[Term]
id: IMR:0000085
name: nuclear receptor
xref_analog: GO:0004879
is_a: IMR:0000369 ! transcriptional regulator
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000086
name: TR
exact_synonym: "c-erbA" []
exact_synonym: "thyroid hormone receptor" []
xref_analog: GO:0004887
is_a: IMR:0000085 ! nuclear receptor

[Term]
id: IMR:0000087
name: cytokeratin 3
is_a: IMR:0000050 ! type II cytokeratin

[Term]
id: IMR:0000088
name: Estrogen receptor
is_a: IMR:0000085 ! nuclear receptor

[Term]
id: IMR:0000089
name: PPAR
exact_synonym: "Peroxisome proliferator activated receptor" []
is_a: IMR:0000085 ! nuclear receptor

[Term]
id: IMR:0000090
name: RAR
exact_synonym: "Retinoic acid receptor" []
is_a: IMR:0000085 ! nuclear receptor

[Term]
id: IMR:0000091
name: receptor serine/threonine kinase
xref_analog: GO:0004675
is_a: IMR:0000223 ! protein serine/threonine kinase
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000092
name: TGF-beta receptor
exact_synonym: "Transforming growth factor-beta receptor" []
xref_analog: GO:0005024
is_a: IMR:0000091 ! receptor serine/threonine kinase

[Term]
id: IMR:0000093
name: TGF-beta receptor type I
exact_synonym: "Transforming growth factor-beta receptor type I" []
xref_analog: GO:0005025
is_a: IMR:0000092 ! TGF-beta receptor

[Term]
id: IMR:0000094
name: TGF-beta receptor type II
exact_synonym: "Transforming growth factor-beta receptor type II" []
xref_analog: GO:0005026
is_a: IMR:0000092 ! TGF-beta receptor

[Term]
id: IMR:0000095
name: cytokine receptor
xref_analog: GO:0004896
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000096
name: interleukin receptor
xref_analog: GO:0004907
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000097
name: IL-2 receptor
exact_synonym: "interleukin-2 receptor" []
xref_analog: GO:0004911
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000098
name: IL-2R alpha chain
exact_synonym: "CD25" []
exact_synonym: "Interleukin-2 receptor alpha chain" []
relationship: part_of IMR:0000097 ! IL-2 receptor

[Term]
id: IMR:0000099
name: IL-2R beta chain
exact_synonym: "CD122" []
exact_synonym: "Interleukin-2 receptor beta chain" []
relationship: part_of IMR:0000097 ! IL-2 receptor
relationship: part_of IMR:0000117 ! IL-15 receptor

[Term]
id: IMR:0000100
name: common gamma chain
exact_synonym: "gamma c" []
exact_synonym: "p64" []
is_a: IMR:0100641 ! IL-13R subunit
is_a: IMR:0100643 ! IL-4R subunit
relationship: part_of IMR:0000097 ! IL-2 receptor
relationship: part_of IMR:0000111 ! IL-7 receptor
relationship: part_of IMR:0000113 ! IL-9 receptor
relationship: part_of IMR:0000117 ! IL-15 receptor

[Term]
id: IMR:0000101
name: IL-5 receptor
exact_synonym: "interleukin-5 receptor" []
xref_analog: GO:0004914
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000102
name: IL-5R alpha
exact_synonym: "interleukin-5 receptor alpha chain" []
relationship: part_of IMR:0000101 ! IL-5 receptor

[Term]
id: IMR:0000103
name: common beta chain
exact_synonym: "beta c" []
relationship: part_of IMR:0000101 ! IL-5 receptor
relationship: part_of IMR:0000109 ! IL-3 receptor
relationship: part_of IMR:0000131 ! GM-CSFR

[Term]
id: IMR:0000104
name: IL-6 receptor
exact_synonym: "interleukin-6 receptor" []
xref_analog: GO:0004915
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000105
name: gp130
exact_synonym: "Interleukin-6 receptor beta chain" []
xref_analog: GO:0004898
is_a: IMR:0000130 ! LIFR
relationship: part_of IMR:0000104 ! IL-6 receptor
relationship: part_of IMR:0000129 ! OSMR

[Term]
id: IMR:0000106
name: IL-6R alpha
exact_synonym: "interleukin-6 receptor alpha chain" []
relationship: part_of IMR:0000104 ! IL-6 receptor

[Term]
id: IMR:0000107
name: IL-4 receptor
exact_synonym: "interleukin-4 receptor" []
xref_analog: GO:0004913
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000108
name: IL-4R alpha
exact_synonym: "interleukin-4 receptor alpha chain" []
is_a: IMR:0100641 ! IL-13R subunit
is_a: IMR:0100643 ! IL-4R subunit

[Term]
id: IMR:0000109
name: IL-3 receptor
exact_synonym: "interleukin-3 receptor" []
xref_analog: GO:0004912
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000110
name: IL-3R alpha
exact_synonym: "interleukin-3 receptor alpha chain" []
relationship: part_of IMR:0000109 ! IL-3 receptor

[Term]
id: IMR:0000111
name: IL-7 receptor
exact_synonym: "interleukin-7 receptor" []
xref_analog: GO:0004917
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000112
name: IL-7R alpha
exact_synonym: "interleukin-7 receptor alpha chain" []
relationship: part_of IMR:0000111 ! IL-7 receptor

[Term]
id: IMR:0000113
name: IL-9 receptor
exact_synonym: "interleukin-9 receptor" []
xref_analog: GO:0004919
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000114
name: IL-9R alpha
exact_synonym: "interleukin-9 receptor alpha chain" []
relationship: part_of IMR:0000113 ! IL-9 receptor

[Term]
id: IMR:0000115
name: IL-13 receptor
exact_synonym: "interleukin-13 receptor" []
xref_analog: GO:0016515
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000116
name: IL-13R alpha-2
exact_synonym: "interleukin-13 receptor alpha-2 chain" []
is_a: IMR:0100641 ! IL-13R subunit

[Term]
id: IMR:0000117
name: IL-15 receptor
exact_synonym: "interleukin-15 receptor" []
xref_analog: GO:0042010
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000118
name: IL-15R alpha
exact_synonym: "interleukin-15 receptor alpha chain" []
relationship: part_of IMR:0000117 ! IL-15 receptor

[Term]
id: IMR:0000120
name: IL-1 receptor
exact_synonym: "interleukin-1 receptor" []
xref_analog: GO:0004908
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000121
name: IL-1RI
exact_synonym: "IL-1R-alpha" []
exact_synonym: "interleukin-1 receptor type I" []
relationship: part_of IMR:0000593 ! IL-1RI : IL-1R AcP

[Term]
id: IMR:0000122
name: IL-1RII
exact_synonym: "IL-1R-beta" []
exact_synonym: "interleukin-1 receptor type II" []
relationship: part_of IMR:0000594 ! IL-1RII : IL-1R AcP

[Term]
id: IMR:0000123
name: IL-18 receptor
exact_synonym: "IL-1Rrp" []
exact_synonym: "IL1 receptor-related protein" []
exact_synonym: "Interleukin-18 receptor" []
xref_analog: GO:0042008
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000124
name: TLR
exact_synonym: "Toll-like receptor" []
is_a: IMR:0001791 ! pattern recognition receptor

[Term]
id: IMR:0000125
name: leptin receptor
exact_synonym: "OB-R" []
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000126
name: c-mpl
exact_synonym: "thrombopoietin receptor" []
exact_synonym: "TPOR" []
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000127
name: EPOR
exact_synonym: "erythropoietin receptor" []
xref_analog: GO:0004900
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000128
name: G-CSFR
exact_synonym: "granulocyte colony-stimulating factor receptor" []
xref_analog: GO:0004902
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000129
name: OSMR
exact_synonym: "oncostatin-M receptor" []
xref_analog: GO:0004924
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000130
name: LIFR
exact_synonym: "leukemia inhibitory factor receptor" []
xref_analog: GO:0004899
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000131
name: GM-CSFR
exact_synonym: "granulocyte-macrophage colony-stimulating factor receptor" []
xref_analog: GO:0004901
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000132
name: GM-CSFR alpha
exact_synonym: "granulocyte-macrophage colony-stimulating factor receptor alpha chain" []
relationship: part_of IMR:0000131 ! GM-CSFR

[Term]
id: IMR:0000133
name: CNTFR
exact_synonym: "ciliary neurotrophic factor receptor" []
xref_analog: GO:0004897
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000134
name: IFNR
exact_synonym: "interferon receptor" []
xref_analog: GO:0004904
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000135
name: IFNR type I
exact_synonym: "IFNAR" []
exact_synonym: "Interferon alpha/beta receptor" []
xref_analog: GO:0004905
is_a: IMR:0000134 ! IFNR

[Term]
id: IMR:0000136
name: IFNR type II
exact_synonym: "IFNGR" []
exact_synonym: "Interferon-gamma receptor" []
xref_analog: GO:0004906
is_a: IMR:0000134 ! IFNR

[Term]
id: IMR:0000137
name: G-Protein Coupled Receptor
exact_synonym: "GPCR" []
xref_analog: GO:0004930
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000138
name: Rhodopsin-like GPCR(typeA)
xref_analog: GO:0001584
is_a: IMR:0000137 ! G-Protein Coupled Receptor

[Term]
id: IMR:0000139
name: secretin like receptors(type B)
xref_analog: GO:0001633
is_a: IMR:0000137 ! G-Protein Coupled Receptor

[Term]
id: IMR:0000140
name: metabotropic glutamate/pheromone receptors(type C)
xref_analog: GO:0008067
is_a: IMR:0000137 ! G-Protein Coupled Receptor

[Term]
id: IMR:0000141
name: patched
xref_analog: GO:0008158
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000142
name: MHC
exact_synonym: "major histocompatibility complex" []
xref_analog: GO:0042611
is_a: IMR:0000950 ! cellular structure protein

[Term]
id: IMR:0000143
name: MHC class I molecule
def: "MHC class Ia (classical) molecules, termed human leukocyte antigen (HLA)-A, HLA-B and HLA-C in humans and H2-K, H2-D and H2-L in mice, are highly polymorphic glycoproteins composed of a single membrane-spanning alpha chain paired with the soluble protein beta2 microglobulin." [ISBN:0815340729, PubMed:10607669, PubMed:16860610]
exact_synonym: "classical MHC class I molecule" []
exact_synonym: "major histocompatibility complex class I molecule" []
exact_synonym: "MHC class Ia molecule" []
xref_analog: GO:0042612
is_a: IMR:0000142 ! MHC

[Term]
id: IMR:0000144
name: MHC class II molecule
def: "MHC class II molecules are composed of membrane-spanning alpha and beta chains." [ISBN:0815340729, PubMed:10607669]
exact_synonym: "classical MHC class II molecule" []
exact_synonym: "major histocompatibility complex class II molecule" []
xref_analog: GO:0042613
is_a: IMR:0000142 ! MHC

[Term]
id: IMR:0000145
name: CD4/CD8
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000146
name: cytokeratin 4
is_a: IMR:0000050 ! type II cytokeratin

[Term]
id: IMR:0000147
name: CD3
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000148
name: CD3 gamma-epsilon dimer
relationship: part_of IMR:0002408 ! alpha beta TCR-CD3 complex
relationship: part_of IMR:0002409 ! gamma delta TCR-CD3 complex

[Term]
id: IMR:0000149
name: CD3 delta-epsilon dimer
relationship: part_of IMR:0002408 ! alpha beta TCR-CD3 complex

[Term]
id: IMR:0000150
name: CD3 zeta-zeta dimer
relationship: part_of IMR:0002408 ! alpha beta TCR-CD3 complex
relationship: part_of IMR:0002409 ! gamma delta TCR-CD3 complex

[Term]
id: IMR:0000151
name: TCR family
exact_synonym: "T-cell receptor" []
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000152
name: scavenger receptor family
xref_analog: GO:0005044
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000153
name: BCR
exact_synonym: "B cell receptor" []
exact_synonym: "B cell receptor complex" []
exact_synonym: "B-cell antigen receptor" []
exact_synonym: "BCR complex" []
xref_analog: GO:0019815
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000154
name: lgM
exact_synonym: "immunoglobulin M" []
is_a: IMR:0002090 ! immunoglobulin
is_a: IMR:0002948 ! mIgM/mIgD

[Term]
id: IMR:0000155
name: Ig alpha:beta
relationship: part_of IMR:0000153 ! BCR
relationship: part_of IMR:0002097 ! pre-BCR

[Term]
id: IMR:0000156
name: FcR
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000157
name: FcepsilonRI
is_a: IMR:0000156 ! FcR

[Term]
id: IMR:0000158
name: FcgammaRI
exact_synonym: "High affinity immunoglobulin gamma Fc receptor I" []
is_a: IMR:0000156 ! FcR

[Term]
id: IMR:0000159
name: FcgammaRIII
exact_synonym: "Low affinity immunoglobulin gamma FC region receptor III" []
is_a: IMR:0000156 ! FcR

[Term]
id: IMR:0000160
name: FcgammaRII
exact_synonym: "Low affinity immunoglobulin gamma Fc region receptor II" []
is_a: IMR:0000156 ! FcR

[Term]
id: IMR:0000161
name: receptor guanylate cyclase
xref_analog: GO:0008075
is_a: IMR:0000314 ! guanylate cyclase
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000162
name: cytokeratin 5
is_a: IMR:0000050 ! type II cytokeratin

[Term]
id: IMR:0000163
name: cytokeratin 7
is_a: IMR:0000050 ! type II cytokeratin

[Term]
id: IMR:0000164
name: cytokeratin 8
is_a: IMR:0000050 ! type II cytokeratin

[Term]
id: IMR:0000165
name: cytokeratin 6A
alt_id: IMR:0000260
exact_synonym: "cytokeratin 6D" []
is_a: IMR:0000469 ! cytokeratin 6

[Term]
id: IMR:0000166
name: adhesion molecule
is_a: IMR:0000950 ! cellular structure protein

[Term]
id: IMR:0000167
name: cadherin
is_a: IMR:0000166 ! adhesion molecule

[Term]
id: IMR:0000168
name: E-cadherin
exact_synonym: "Arc-1" []
exact_synonym: "cadherin-1" []
exact_synonym: "cell-CAM120/80" []
exact_synonym: "Epithelial-cadherin" []
exact_synonym: "L-CAM" []
exact_synonym: "Uvomorulin" []
is_a: IMR:0000167 ! cadherin

[Term]
id: IMR:0000169
name: N-cadherin
exact_synonym: "A-CAM" []
exact_synonym: "cadherin-2" []
exact_synonym: "Neural-cadherin" []
is_a: IMR:0000167 ! cadherin

[Term]
id: IMR:0000170
name: R-cadherin
exact_synonym: "cadherin-4" []
exact_synonym: "Retinal-cadherin" []
is_a: IMR:0000167 ! cadherin

[Term]
id: IMR:0000171
name: VE-cadherin
exact_synonym: "cadherin-5" []
exact_synonym: "Vascular endothelial-cadherin" []
is_a: IMR:0000167 ! cadherin

[Term]
id: IMR:0000172
name: integrin
def: "Integrins comprise a large family of cell surface receptors that are found in many animal species, ranging from sponge to mammals. They are composed of two subunits, alpha and beta, and each alpha beta combination has its own binding specificity and signaling properties." [PubMed:10446041]
is_a: IMR:0000166 ! adhesion molecule
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000173
name: Integrin alpha
is_a: IMR:0000172 ! integrin

[Term]
id: IMR:0000174
name: Integrin beta
is_a: IMR:0000172 ! integrin

[Term]
id: IMR:0000176
name: alpha-catenin
is_a: IMR:0000166 ! adhesion molecule

[Term]
id: IMR:0000177
name: beta-catenin
comment: named 'beta-catenin family' formerly.
is_a: IMR:0000166 ! adhesion molecule
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000178
name: ICAM
exact_synonym: "intercellular adhesion molecule" []
is_a: IMR:0000166 ! adhesion molecule

[Term]
id: IMR:0000180
name: N-CAM
exact_synonym: "neuronal cell adhesion molecule" []
is_a: IMR:0000166 ! adhesion molecule

[Term]
id: IMR:0000182
name: selectin
is_a: IMR:0000166 ! adhesion molecule

[Term]
id: IMR:0000183
name: nectin
is_a: IMR:0000166 ! adhesion molecule

[Term]
id: IMR:0000184
name: ponsin
is_a: IMR:0000166 ! adhesion molecule

[Term]
id: IMR:0000185
name: cytoskeletal protein
xref_analog: GO:0005200
xref_analog: GO:0005856
is_a: IMR:0000950 ! cellular structure protein

[Term]
id: IMR:0000186
name: ERM family
exact_synonym: "ezrin/radixin/moesin family" []
is_a: IMR:0000185 ! cytoskeletal protein

[Term]
id: IMR:0000187
name: paxillin
is_a: IMR:0000188 ! microfilament cytoskeletal protein
is_a: IMR:0000333 ! adaptor protein

[Term]
id: IMR:0000188
name: microfilament cytoskeletal protein
exact_synonym: "actin filament cytoskeletal protein" []
xref_analog: GO:0015629
is_a: IMR:0000185 ! cytoskeletal protein

[Term]
id: IMR:0000189
name: alpha-actinin
is_a: IMR:0000477 ! actin cross linking protein

[Term]
id: IMR:0000190
name: actin
is_a: IMR:0000494 ! microfilament protein

[Term]
id: IMR:0000191
name: myosin
is_a: IMR:0000188 ! microfilament cytoskeletal protein
is_a: IMR:0000518 ! motor protein

[Term]
id: IMR:0000192
name: tropomyosin
is_a: IMR:0000188 ! microfilament cytoskeletal protein

[Term]
id: IMR:0000193
name: troponin
is_a: IMR:0000188 ! microfilament cytoskeletal protein

[Term]
id: IMR:0000194
name: profilin
is_a: IMR:0000188 ! microfilament cytoskeletal protein

[Term]
id: IMR:0000195
name: spectrin
is_a: IMR:0000188 ! microfilament cytoskeletal protein

[Term]
id: IMR:0000196
name: microtubule cytoskeletal protein
xref_analog: GO:0015630
is_a: IMR:0000185 ! cytoskeletal protein

[Term]
id: IMR:0000197
name: tubulin
is_a: IMR:0000495 ! microtubule protein

[Term]
id: IMR:0000199
name: kinesin
is_a: IMR:0100192 ! kinesin superfamily

[Term]
id: IMR:0000200
name: dynein
is_a: IMR:0000196 ! microtubule cytoskeletal protein
is_a: IMR:0000518 ! motor protein

[Term]
id: IMR:0000201
name: intermediate filament cytoskeletal protein
xref_analog: GO:0045111
is_a: IMR:0000185 ! cytoskeletal protein

[Term]
id: IMR:0000202
name: keratin
exact_synonym: "cytokeratin" []
is_a: IMR:0000496 ! intermediate filament protein

[Term]
id: IMR:0000203
name: neurofilament protein
xref_analog: GO:0005883
is_a: IMR:0000496 ! intermediate filament protein

[Term]
id: IMR:0000204
name: dystrophin
is_a: IMR:0000185 ! cytoskeletal protein

[Term]
id: IMR:0000205
name: APC
exact_synonym: "Adenomatous Polyposis Coli Protein" []
is_a: IMR:0000185 ! cytoskeletal protein
is_a: IMR:0001160 ! negative regulator of Wnt signaling pathway

[Term]
id: IMR:0000206
name: ankyrin
is_a: IMR:0000185 ! cytoskeletal protein

[Term]
id: IMR:0000207
name: enzyme
def: "Protein that catalyze a specific chemical reaction." [ISBN:0815340729]
xref_analog: GO:0003824
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000208
name: cytokeratin 6B
alt_id: IMR:0000302
exact_synonym: "cytokeratin 6F" []
is_a: IMR:0000469 ! cytokeratin 6

[Term]
id: IMR:0000209
name: protein kinase
xref_analog: GO:0004672
is_a: IMR:0000512 ! kinase

[Term]
id: IMR:0000210
name: protein tyrosine kinase
exact_synonym: "PTK" []
xref_analog: GO:0004713
is_a: IMR:0000209 ! protein kinase

[Term]
id: IMR:0000211
name: Src family
is_a: IMR:0000682 ! non-receptor tyrosine kinase

[Term]
id: IMR:0000212
name: Csk
exact_synonym: "C-terminal Src kinase" []
is_a: IMR:0000682 ! non-receptor tyrosine kinase

[Term]
id: IMR:0000213
name: JAK
def: "Janus kinases (Jaks) are non-receptor tyrosine kinases. In mammals, the family has four members, Jak1, Jak2, Jak3 and Tyrosine kinase 2 (Tyk2). In Drosophila there is only one Jak kinase, Hopscotch (Hop)." [PubMed:15575979]
exact_synonym: "Janus kinase" []
xref_analog: GO:0004718
is_a: IMR:0000682 ! non-receptor tyrosine kinase

[Term]
id: IMR:0000214
name: BTK/Tec
is_a: IMR:0000682 ! non-receptor tyrosine kinase

[Term]
id: IMR:0000215
name: BTK
exact_synonym: "Atk" []
exact_synonym: "Bpk" []
exact_synonym: "Bruton's tyrosine kinase" []
exact_synonym: "Emb" []
is_a: IMR:0000214 ! BTK/Tec

[Term]
id: IMR:0000216
name: Tec
exact_synonym: "Tec protein tyrosine kinase" []
is_a: IMR:0000214 ! BTK/Tec

[Term]
id: IMR:0000217
name: Fak/Pyk2
is_a: IMR:0000682 ! non-receptor tyrosine kinase

[Term]
id: IMR:0000218
name: Fak
exact_synonym: "Focal adhesion kinase" []
xref_analog: GO:0004717
is_a: IMR:0000217 ! Fak/Pyk2

[Term]
id: IMR:0000219
name: Pyk2
exact_synonym: "CADTK" []
exact_synonym: "Cak beta" []
exact_synonym: "calcium-dependent tyrosine kinase" []
exact_synonym: "cell adhesion kinase beta" []
exact_synonym: "prolin-rich tyrosine kinase 2" []
exact_synonym: "RAFTK" []
exact_synonym: "related adhesion focal tyrosine kinase" []
is_a: IMR:0000217 ! Fak/Pyk2

[Term]
id: IMR:0000220
name: ZAP-70/Syk
is_a: IMR:0000682 ! non-receptor tyrosine kinase

[Term]
id: IMR:0000221
name: ZAP-70
is_a: IMR:0000220 ! ZAP-70/Syk

[Term]
id: IMR:0000222
name: Syk
exact_synonym: "Spleen tyrosine kinase" []
is_a: IMR:0000220 ! ZAP-70/Syk

[Term]
id: IMR:0000223
name: protein serine/threonine kinase
xref_analog: GO:0004674
is_a: IMR:0000209 ! protein kinase

[Term]
id: IMR:0000224
name: MAPK
def: "Mammals express at least four distinctly regulated groups of MAPKs, ERK-1/2, JNK/SAPK, p38 and ERK5. MAPKs are activated by dual phosphorylation on both tyrosine and threonine residues of a conserved TXY motif." [PubMed:11242034, PubMed:9922370]
exact_synonym: "MAP kinase" []
exact_synonym: "mitogen-activated protein kinase" []
xref_analog: GO:0004707
xref_analog: IPR:003527
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000225
name: JNK/SAPK
exact_synonym: "c-jun N-terminal kinase" []
exact_synonym: "stress-activated protein kinase" []
xref_analog: GO:0016909
xref_analog: IPR:008351
is_a: IMR:0000224 ! MAPK

[Term]
id: IMR:0000226
name: p38
xref_analog: IPR:008352
is_a: IMR:0000224 ! MAPK

[Term]
id: IMR:0000227
name: ERK1/2
def: "ERK1 and ERK2 are isoforms of the 'classical' MAPK. Both ERK1 and ERK2 (referred to as ERK1/2) are activated by MAP/ERK kinase 1 (MEK1) and MEK2 (referred to as MEK1/2). MEK1/2 phosphorylates threonine and tyrosine residues in the Thr-Glu-Tyr (TEY) sequence of ERK1/2. Activated ERK1/2 phosphorylates many substrates including transcription factors, such as Elk1 and c-Myc, and protein kinases, such as ribosomal S6 kinase (RSK)." [PubMed:16880823]
exact_synonym: "ERK" []
exact_synonym: "Extracellular signal-regulated kinase" []
exact_synonym: "MAPK/ERK" []
exact_synonym: "p42/p44 MAP kinase" []
exact_synonym: "p42/p44 MAPK" []
xref_analog: IPR:008349
is_a: IMR:0000224 ! MAPK

[Term]
id: IMR:0000229
name: MAPKKK
exact_synonym: "MAP kinase kinase kinase" []
exact_synonym: "MAPKK kinase" []
exact_synonym: "MKKK" []
xref_analog: GO:0004709
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000230
name: mos
exact_synonym: "c-mos" []
is_a: IMR:0000229 ! MAPKKK

[Term]
id: IMR:0000231
name: Raf
is_a: IMR:0000229 ! MAPKKK

[Term]
id: IMR:0000232
name: TAK1
exact_synonym: "MOM-4" []
exact_synonym: "TGF-bata activated kinase 1" []
is_a: IMR:0000229 ! MAPKKK

[Term]
id: IMR:0000233
name: Tpl2
exact_synonym: "cancer Osaka thyroid oncogene" []
exact_synonym: "Cot" []
exact_synonym: "Est" []
exact_synonym: "Tumor progression locus 2" []
is_a: IMR:0000229 ! MAPKKK

[Term]
id: IMR:0000234
name: MEKK
exact_synonym: "MAPK/ERK kinase kinase" []
xref_analog: GO:0004710
is_a: IMR:0000229 ! MAPKKK

[Term]
id: IMR:0000238
name: PAK
is_a: IMR:0000229 ! MAPKKK
is_a: IMR:0000252 ! Ste20 homolog family

[Term]
id: IMR:0000239
name: MLK family
is_a: IMR:0000229 ! MAPKKK

[Term]
id: IMR:0000242
name: NIK
exact_synonym: "NF-kappa B-inducing kinase" []
xref_analog: GO:0004704
is_a: IMR:0000229 ! MAPKKK

[Term]
id: IMR:0000243
name: IKK complex
exact_synonym: "I-kappaB kinase complex" []
xref_analog: GO:0008385
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000244
name: cytokeratin 6C
alt_id: IMR:0000270
exact_synonym: "cytokeratin 6E" []
is_a: IMR:0000469 ! cytokeratin 6

[Term]
id: IMR:0000245
name: PKC
exact_synonym: "protein kinase C" []
xref_analog: GO:0004697
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000246
name: nPKC
def: "novel PKC isoforms (delta, epsilon, eta and theta) are regulated by DAG and phospholipids." [PubMed:15282562]
exact_synonym: "novel protein kinase C" []
is_a: IMR:0000245 ! PKC

[Term]
id: IMR:0000247
name: aPKC
def: "atypical PKC isoforms (zeta and lambda/iota; PKC-lambda is the mouse ortholog of human PKC-iota) are insensitive to both calcium and DAG." [PubMed:15282562]
exact_synonym: "atypical protein kinase C" []
xref_analog: GO:0004700
is_a: IMR:0000245 ! PKC

[Term]
id: IMR:0000248
name: RSK
def: "A family of 90 kDa ribosomal S6 kinases (RSK; also known as p90rsk or MAPK-activated protein kinase-1, MAPKAP-K1). The RSK family of kinases includes three isoforms: RSK1, RSK2 and RSK3 that are encoded by distinct genes and show 75-80% amino acid identity. RSK proteins is regulated by the ERK kinase pathway." [PubMed:10411321]
exact_synonym: "90 kDa ribosomal S6 kinase" []
exact_synonym: "MAPK-activated protein kinase-1" []
exact_synonym: "MAPKAP kinase-1" []
exact_synonym: "MAPKAP-K1" []
exact_synonym: "p90rsk" []
xref_analog: GO:0004711
is_a: IMR:0001844 ! S6K
is_a: IMR:0100271 ! MAPKAPK

[Term]
id: IMR:0000249
name: PKA
def: "PKA is comprised of two types of subunits. Two catalytic (C) subunits bind to a regulatory (R) subunit dimer to form an inactive holoenzyme complex. Binding of cAMP to the regulatory subunit causes the catalytic subunit to be unleashed." [PubMed:17996741]
exact_synonym: "cAMP-dependent protein kinase" []
exact_synonym: "protein kinase A" []
xref_analog: GO:0004691
xref_analog: GO:0005952
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000250
name: Akt
exact_synonym: "PKB" []
exact_synonym: "protein kinase B" []
exact_synonym: "RAC serine/threonine protein kinase" []
exact_synonym: "RAC-PK" []
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000251
name: PKG
exact_synonym: "cGMP-dependent protein kinase" []
xref_analog: GO:0004692
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000252
name: Ste20 homolog family
is_a: IMR:0100207 ! MAPKKKK

[Term]
id: IMR:0000253
name: mammalian Ste20-like kinases (MAPKKKK)
is_a: IMR:0000252 ! Ste20 homolog family

[Term]
id: IMR:0000254
name: G-protein coupled receptor kinase
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000255
name: PDK
alt_id: IMR:0010402
exact_synonym: "3-phosphoinositide dependent protein kinase-1" []
exact_synonym: "hPDK1" []
exact_synonym: "phosphatidylinositol-dependent kinase" []
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000256
name: Plk
exact_synonym: "polo-like kinase" []
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000257
name: GSK3
exact_synonym: "glycogen synthase kinase 3" []
xref_analog: GO:0004696
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000258
name: protein serine/threonine/tyrosine kinase
exact_synonym: "dual specificity kinase" []
xref_analog: GO:0004712
is_a: IMR:0000209 ! protein kinase

[Term]
id: IMR:0000259
name: MAPKK
exact_synonym: "MAP kinase kinase" []
exact_synonym: "MAPK kinase" []
xref_analog: GO:0004708
is_a: IMR:0000258 ! protein serine/threonine/tyrosine kinase

[Term]
id: IMR:0000261
name: MEK1/2(MKK1/2)
def: "MEK1 and MEK2 phosphorylate and activate ERK1 and ERK2 MAP kinases." [PubMed:11242034, PubMed:9922370]
exact_synonym: "MAPKK1/2" []
exact_synonym: "MEK" []
exact_synonym: "MEK1/2" []
exact_synonym: "MKK1/2" []
is_a: IMR:0000259 ! MAPKK

[Term]
id: IMR:0000262
name: MKK4/7(JNKK1/2)
def: "MKK4 and MKK7 phosphorylate and activate JNK MAP kinases." [PubMed:11242034, PubMed:9922370]
is_a: IMR:0000259 ! MAPKK

[Term]
id: IMR:0000263
name: MKK3/6
def: "MKK3 and MKK6 phosphorylate and activate p38 MAP kinases." [PubMed:11242034, PubMed:9922370]
is_a: IMR:0000259 ! MAPKK

[Term]
id: IMR:0000264
name: inositol/phosphatidylinositol kinase
xref_analog: GO:0004428
is_a: IMR:0000512 ! kinase

[Term]
id: IMR:0000265
name: PI3-kinase
exact_synonym: "phosphatidylinositol 3-kinase" []
exact_synonym: "PI3K" []
xref_analog: GO:0016303
is_a: IMR:0000264 ! inositol/phosphatidylinositol kinase

[Term]
id: IMR:0000266
name: PI3-kinase p85 subunit
exact_synonym: "Phosphatidylinositol 3-kinase p85 regulatory subunit" []
is_a: IMR:0000429 ! enzyme regulator
relationship: part_of IMR:0000265 ! PI3-kinase

[Term]
id: IMR:0000267
name: PI3-kinase p110 subunit
exact_synonym: "Phosphatidylinositol 3-kinase p110 catalytic subunit" []
is_a: IMR:0000264 ! inositol/phosphatidylinositol kinase
relationship: part_of IMR:0000265 ! PI3-kinase

[Term]
id: IMR:0000268
name: PI5k
is_a: IMR:0000264 ! inositol/phosphatidylinositol kinase

[Term]
id: IMR:0000269
name: RIP
exact_synonym: "Receptor interacting protein" []
exact_synonym: "Receptor-interacting serine/threonine protein kinase" []
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000271
name: SHIP
exact_synonym: "Src homology-2 domain-containing inositol 5'-phosphatase" []
is_a: IMR:0100365 ! inositol/phosphatidylinositol phosphatase

[Term]
id: IMR:0000272
name: protein phosphatase
xref_analog: GO:0004721
is_a: IMR:0000517 ! phosphatase

[Term]
id: IMR:0000273
name: protein tyrosine phosphatase
xref_analog: EC:3.1.3.48
xref_analog: GO:0004725
is_a: IMR:0000272 ! protein phosphatase

[Term]
id: IMR:0000274
name: SHP family
is_a: IMR:0100337 ! non-receptor protein tyrosine phosphatase

[Term]
id: IMR:0000275
name: SHP-1
exact_synonym: "HCP" []
exact_synonym: "PTP1C" []
exact_synonym: "SH-PTP1" []
exact_synonym: "Src homology 2-containing protein tyrosine phosphatase-1" []
is_a: IMR:0000274 ! SHP family

[Term]
id: IMR:0000276
name: SHP-2
exact_synonym: "PTP1D" []
exact_synonym: "SH-PTP2" []
exact_synonym: "Src homology 2-containing protein tyrosine phosphatase-2" []
exact_synonym: "Syp" []
is_a: IMR:0000274 ! SHP family

[Term]
id: IMR:0000277
name: protein serine/threonine phosphatase
xref_analog: EC:3.1.3.16
xref_analog: GO:0004722
is_a: IMR:0000272 ! protein phosphatase

[Term]
id: IMR:0000278
name: calcineurin
exact_synonym: "Ca2+/calmodulin-dependent protein phosphatase" []
exact_synonym: "CN" []
exact_synonym: "PP2B" []
exact_synonym: "protein phosphatase type 2B" []
xref_analog: GO:0030357
is_a: IMR:0000277 ! protein serine/threonine phosphatase

[Term]
id: IMR:0000279
name: PP1
xref_analog: GO:0000163
is_a: IMR:0000277 ! protein serine/threonine phosphatase

[Term]
id: IMR:0000280
name: PP2A
exact_synonym: "protein phosphatase 2A" []
xref_analog: GO:0000158
is_a: IMR:0000277 ! protein serine/threonine phosphatase

[Term]
id: IMR:0000281
name: phospholipase
xref_analog: GO:0004620
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0000283
name: PLA2
exact_synonym: "phospholipase A2" []
xref_analog: EC:3.1.1.4
xref_analog: GO:0004623
is_a: IMR:0000281 ! phospholipase

[Term]
id: IMR:0000284
name: PLC
exact_synonym: "phospholipase C" []
xref_analog: EC:3.1.4.11
xref_analog: GO:0004629
is_a: IMR:0000281 ! phospholipase

[Term]
id: IMR:0000285
name: PLC gamma
exact_synonym: "phospholipase C gamma" []
is_a: IMR:0000284 ! PLC

[Term]
id: IMR:0000286
name: PLCbeta
exact_synonym: "phospholipase C beta" []
is_a: IMR:0000284 ! PLC

[Term]
id: IMR:0000287
name: PLD
exact_synonym: "phospholipase D" []
xref_analog: EC:3.1.4.4
xref_analog: GO:0004630
is_a: IMR:0000281 ! phospholipase

[Term]
id: IMR:0000288
name: small GTPase
def: "The RAS superfamily of GTP (guanosine triphosphate) hydrolysis-coupled signal transduction relay proteins can be subclassified into RAS, RHO, RAB, and ARF families, as well as the closely related G alpha family. The members of each family can, in turn, be arranged into evolutionarily conserved branches. These groupings reflect structural, biochemical, and functional conservation." [PubMed:15367757, PubMed:15731001]
exact_synonym: "Ras superfamily" []
exact_synonym: "small G-protein" []
exact_synonym: "small GTP-binding protein" []
xref_analog: EC:3.6.5.2
xref_analog: IPR:001806
is_a: IMR:0000914 ! GTP-binding protein
is_a: IMR:0000960 ! GTPase

[Term]
id: IMR:0000289
name: Ras family
xref_analog: IPR:003577
is_a: IMR:0000288 ! small GTPase

[Term]
id: IMR:0000290
name: Ras
exact_synonym: "Ras GTPase" []
is_a: IMR:0000289 ! Ras family

[Term]
id: IMR:0000291
name: K-Ras
is_a: IMR:0000290 ! Ras

[Term]
id: IMR:0000292
name: R-Ras
exact_synonym: "related to Ras" []
is_a: IMR:0000289 ! Ras family

[Term]
id: IMR:0000293
name: Ral
exact_synonym: "Ras-like" []
is_a: IMR:0000289 ! Ras family

[Term]
id: IMR:0000294
name: Rap
exact_synonym: "Ras proximal" []
is_a: IMR:0000289 ! Ras family

[Term]
id: IMR:0000295
name: Rho family
xref_analog: IPR:003578
is_a: IMR:0000288 ! small GTPase

[Term]
id: IMR:0000296
name: Rho
is_a: IMR:0000295 ! Rho family

[Term]
id: IMR:0000297
name: Rac
is_a: IMR:0000295 ! Rho family

[Term]
id: IMR:0000298
name: Cdc42 (yeast)
comment: This term was made obsolete. To update annotations, consider the term 'IMR0000699:Cdc42'.
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0000299
name: Rab
exact_synonym: "Ras genes from rat brain" []
xref_analog: IPR:003579
is_a: IMR:0000288 ! small GTPase

[Term]
id: IMR:0000300
name: Ran
exact_synonym: "Ras-like nuclear protein" []
exact_synonym: "TC4" []
xref_analog: IPR:002041
is_a: IMR:0000288 ! small GTPase
is_a: IMR:0000653 ! nucleocytoplasmic transport protein

[Term]
id: IMR:0000301
name: Arf/Sar
is_a: IMR:0000288 ! small GTPase

[Term]
id: IMR:0000303
name: Sar
xref_analog: GO:0003932
is_a: IMR:0000301 ! Arf/Sar
is_a: IMR:0000654 ! vesicular transport protein

[Term]
id: IMR:0000304
name: protease
exact_synonym: "peptidase" []
xref_analog: EC:3.4.-.-
xref_analog: GO:0008233
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0000305
name: caspase
xref_analog: GO:0030693
is_a: IMR:0000304 ! protease

[Term]
id: IMR:0000306
name: effector caspase
xref_analog: GO:0004207
is_a: IMR:0000305 ! caspase

[Term]
id: IMR:0000308
name: signaling (initiator) caspase
xref_analog: GO:0004200
is_a: IMR:0000305 ! caspase

[Term]
id: IMR:0000310
name: 26S proteasome
def: "The 26S proteasome is a 2.5-MDa molecular machine built from ~31 different subunits, which catalyzes protein degradation. It contains a barrel-shaped proteolytic core complex (the 20S proteasome), capped at one or both ends by 19S regulatory complexes, which recognize ubiquitinated proteins." [PubMed:10872471, PubMed:9228274, PubMed:9647729]
xref_analog: GO:0000502
is_a: IMR:0000304 ! protease

[Term]
id: IMR:0000311
name: 20S proteasome
exact_synonym: "20S catalytic complex" []
exact_synonym: "20S core particle" []
xref_analog: GO:0005839
relationship: part_of IMR:0000310 ! 26S proteasome

[Term]
id: IMR:0000312
name: 19S regulatory complex
exact_synonym: "PA700 activator" []
xref_analog: GO:0005838
is_a: IMR:0001014 ! proteasome activator subunit
relationship: part_of IMR:0000310 ! 26S proteasome

[Term]
id: IMR:0000313
name: adenylate cyclase
xref_analog: EC:4.6.1.1
xref_analog: GO:0004016
is_a: IMR:0000961 ! cyclase

[Term]
id: IMR:0000314
name: guanylate cyclase
exact_synonym: "guanylyl cyclase" []
xref_analog: EC:4.6.1.2
xref_analog: GO:0004383
is_a: IMR:0000961 ! cyclase

[Term]
id: IMR:0000315
name: trimeric G-protein
exact_synonym: "G-protein" []
exact_synonym: "heterotrimeric G-protein" []
exact_synonym: "trimeric GTP-binding protein" []
is_a: IMR:0000914 ! GTP-binding protein

[Term]
id: IMR:0000316
name: G-alpha
exact_synonym: "G-protein, alpha subunit" []
exact_synonym: "Guanine nucleotide-binding protein, alpha subunit" []
xref_analog: EC:3.6.5.1
is_a: IMR:0000960 ! GTPase
relationship: part_of IMR:0000315 ! trimeric G-protein

[Term]
id: IMR:0000317
name: G-alpha-s class
is_a: IMR:0000316 ! G-alpha

[Term]
id: IMR:0000318
name: G-alpha-i class
is_a: IMR:0000316 ! G-alpha

[Term]
id: IMR:0000319
name: G-alpha-i
is_a: IMR:0000318 ! G-alpha-i class

[Term]
id: IMR:0000320
name: G-alpha-o
alt_id: IMR:0100371
alt_id: IMR:0100372
def: "Galphao, the most abundant G protein in mammalian brain, occurs at least in two subforms, i.e., Galphao1 and Galphao2, derived by alternative splicing of the mRNA." [PubMed:9990023]
is_a: IMR:0000318 ! G-alpha-i class

[Term]
id: IMR:0000321
name: G-alpha-t
exact_synonym: "transducin alpha" []
is_a: IMR:0000318 ! G-alpha-i class

[Term]
id: IMR:0000322
name: G-alpha-z
is_a: IMR:0000318 ! G-alpha-i class

[Term]
id: IMR:0000323
name: G-alpha-q class
is_a: IMR:0000316 ! G-alpha

[Term]
id: IMR:0000324
name: G-alpha-12/13 class
is_a: IMR:0000316 ! G-alpha

[Term]
id: IMR:0000325
name: G-beta
exact_synonym: "G-protein beta subunit" []
is_a: IMR:0000428 ! signal regulator
relationship: part_of IMR:0100018 ! G-betagamma dimers

[Term]
id: IMR:0000326
name: G-gamma
exact_synonym: "G-protein gamma subunit" []
is_a: IMR:0000428 ! signal regulator
relationship: part_of IMR:0100018 ! G-betagamma dimers

[Term]
id: IMR:0000327
name: ubiquitin-activating enzyme (E1)
xref_analog: GO:0004839
is_a: IMR:0000959 ! ubiquitin related enzyme

[Term]
id: IMR:0000328
name: ubiquitin-conjugating enzyme (E2)
xref_analog: GO:0004840
is_a: IMR:0000959 ! ubiquitin related enzyme

[Term]
id: IMR:0000329
name: ubiquitin ligase (E3)
xref_analog: GO:0004842
is_a: IMR:0000959 ! ubiquitin related enzyme
is_a: IMR:0010053 ! ligase

[Term]
id: IMR:0000330
name: deubiquitinating enzyme
def: "Deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin from ubiquitin-conjugated substrate proteins. DUBs constitute large gene families in eukaryotes." [PubMed:12944365, PubMed:15180524]
exact_synonym: "DUB" []
exact_synonym: "ubiquitin-specific protease" []
xref_analog: GO:0004843
is_a: IMR:0000959 ! ubiquitin related enzyme

[Term]
id: IMR:0000331
name: COX
exact_synonym: "prostaglandin endoperoxide synthase" []
xref_analog: EC:1.14.99.1
is_a: IMR:0000952 ! oxidoreductase

[Term]
id: IMR:0000332
name: phosphodiesterase
exact_synonym: "PDE" []
xref_analog: EC:3.1.4.-
xref_analog: GO:0008081
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0000333
name: adaptor protein
def: "General term for proteins in intracellular signaling pathways that link different proteins in the pathway directly together." [ISBN:0815340729, PubMed:9405336]
comment: named 'adaptor/docking/scaffold/anchoring protein' formerly.
narrow_synonym: "anchoring protein" []
narrow_synonym: "docking protein" []
narrow_synonym: "scaffold protein" []
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000334
name: SH2/SH3 adaptor protein
def: "This term refers to the adaptor proteins that possesses both SH2 and SH3 domains, such as Grb2, Nck and Crk, and does not include adaptor proteins that contain only SH2 or PTB domains, such as the Shc family and the IRS family." [PubMed:10393272]
xref_analog: GO:0005070
is_a: IMR:0000333 ! adaptor protein

[Term]
id: IMR:0000335
name: Crk
def: "Alternative splicing of the mammal crk gene yields two translation products designated the 28-kDa Crk-I and the 42-kDa Crk-II protein. " [PubMed:10393272]
exact_synonym: "CT-10 regulator of kinase" []
exact_synonym: "Proto-oncogene C-crk" []
is_a: IMR:0000745 ! Crk family

[Term]
id: IMR:0000336
name: Crk I
is_a: IMR:0000335 ! Crk

[Term]
id: IMR:0000337
name: Crk-L
exact_synonym: "Crk-like protein" []
is_a: IMR:0000745 ! Crk family

[Term]
id: IMR:0000338
name: Crk II
is_a: IMR:0000335 ! Crk

[Term]
id: IMR:0000339
name: Grb2 family
def: "The best characterised member of the SH2/SH3 adaptor protein family is Grb2, the human homologue of the nematode Caenorhabditis elegans protein Sem-5. The structure of Grb2 consists of one SH2 domain flanked by two SH3 domains. Recently, further members of the Grb2 family have been isolated, Grap protein and Gads." [PubMed:10393272]
is_a: IMR:0000334 ! SH2/SH3 adaptor protein

[Term]
id: IMR:0000340
name: Grb2
alt_id: IMR:0010276
exact_synonym: "abundant Src homology protein" []
exact_synonym: "Ash" []
exact_synonym: "ASH protein" []
exact_synonym: "GRB2 adapter protein" []
exact_synonym: "growth factor receptor bound protein 2" []
exact_synonym: "Growth factor receptor-bound protein 2" []
exact_synonym: "SH2/SH3 adapter GRB2" []
is_a: IMR:0000339 ! Grb2 family

[Term]
id: IMR:0000341
name: Grap
exact_synonym: "Grb2-related adaptor protein" []
is_a: IMR:0000339 ! Grb2 family

[Term]
id: IMR:0000342
name: Nck family
def: "The widely expressed Nck is a 47-kDa cytosolic protein exclusively composed of one SH2 and three SH3 domains. Recently, a second member of the Nck family has been isolated (Nck beta/Grb4) which shows 68% amino acid identity to Nck (Nck alpha)." [PubMed:10393272]
is_a: IMR:0000334 ! SH2/SH3 adaptor protein

[Term]
id: IMR:0000343
name: Nck
alt_id: IMR:0011207
exact_synonym: "Cytoplasmic protein NCK1" []
exact_synonym: "IRS-4a-P" []
exact_synonym: "NCK adaptor protein 1" []
exact_synonym: "Nck alpha" []
exact_synonym: "SH2/SH3 adaptor protein NCK-alpha" []
is_a: IMR:0000342 ! Nck family

[Term]
id: IMR:0000344
name: Nck beta/Grb4
alt_id: IMR:0011208
exact_synonym: "Cytoplasmic protein NCK2" []
exact_synonym: "IRS-4b-P" []
exact_synonym: "NCK adaptor protein 2" []
exact_synonym: "Nck-2" []
exact_synonym: "SH2/SH3 adaptor protein NCK-beta" []
is_a: IMR:0000342 ! Nck family

[Term]
id: IMR:0000345
name: docking protein
def: "Typically, docking proteins have an NH2-terminal membrane-targeting element, either a PH domain or a myristylation site, and a PTB domain that directs association with an NPXY autophosphorylation site on a specific receptor. The kinase domain of the activated receptor phosphorylates Tyr residues in the docking protein that act as docking sites for multiple SH2-domain signaling proteins." [PubMed:11057895, PubMed:9405336]
is_a: IMR:0000333 ! adaptor protein

[Term]
id: IMR:0000346
name: Dok
exact_synonym: "Downstream of tyrosine kinase" []
is_a: IMR:0000345 ! docking protein

[Term]
id: IMR:0000347
name: Shc
exact_synonym: "src homology and collagen" []
is_a: IMR:0000345 ! docking protein

[Term]
id: IMR:0000348
name: LAT
exact_synonym: "linker for activation of T cell" []
is_a: IMR:0000345 ! docking protein

[Term]
id: IMR:0000349
name: Lnk
is_a: IMR:0000345 ! docking protein

[Term]
id: IMR:0000350
name: SLP-76
exact_synonym: "SH2 domain-containing leukocyte protein of 76 kD" []
is_a: IMR:0100258 ! SLP-76 family

[Term]
id: IMR:0000351
name: IRS
exact_synonym: "insulin receptor substrate" []
is_a: IMR:0000345 ! docking protein

[Term]
id: IMR:0000352
name: cytokeratin 9
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000353
name: BLNK/SLP-65
is_a: IMR:0100258 ! SLP-76 family

[Term]
id: IMR:0000354
name: Cas family
exact_synonym: "CRK-associated substrate family" []
is_a: IMR:0000345 ! docking protein

[Term]
id: IMR:0000355
name: p130Cas
exact_synonym: "Cas" []
exact_synonym: "p130 Crk associated substrate" []
is_a: IMR:0000354 ! Cas family

[Term]
id: IMR:0000356
name: Cbl
is_a: IMR:0000333 ! adaptor protein

[Term]
id: IMR:0000357
name: Grb7
exact_synonym: "Growth factor receptor-bound protein 7" []
is_a: IMR:0100382 ! Grb7/10/14 family

[Term]
id: IMR:0000358
name: HS1
exact_synonym: "LckBP1" []
exact_synonym: "SPY75" []
is_a: IMR:0000333 ! adaptor protein

[Term]
id: IMR:0000359
name: scaffold protein
comment: This term was made obsolete. To update annotations, consider the term 'IMR0000333:adaptor protein'.
xref_analog: GO:0030159
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0000360
name: PSD95
exact_synonym: "SAP90" []
exact_synonym: "synapse-associated protein 90" []
is_a: IMR:0000333 ! adaptor protein

[Term]
id: IMR:0000361
name: MAP-kinase scaffold protein
xref_analog: GO:0005078
is_a: IMR:0000333 ! adaptor protein

[Term]
id: IMR:0000362
name: cytokeratin 10
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000363
name: cytokeratin 12
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000364
name: cytokeratin 13
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000365
name: cytokeratin 14
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000366
name: cytokeratin 15
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000367
name: cytokeratin 16
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000368
name: transcription factor
def: "Term loosely applied to any protein required to initiate or regulate transcription in eucaryotes. Includes both gene regulatory proteins as well as the general transcription factors." [ISBN:0815340729]
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000369
name: transcriptional regulator
exact_synonym: "transcription regulatory factor" []
is_a: IMR:0000368 ! transcription factor

[Term]
id: IMR:0000370
name: Smad
def: "Smads is a conserved family of signal transducers. Functionally, Smads fall into three subfamilies:R-Smads; Co-Smads; I-Smads. Eight Smad proteins are encoded in vertebrate, four in Drosophila, and three in C. elegans." [PubMed:11792802, PubMed:16322555, PubMed:9393997]
exact_synonym: "SMAD" []
xref_analog: IPR:001132
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000371
name: R-Smad
def: "There are five vertebrate R-Smads, Smad1, Smad2, Smad3, Smad5 and Smad8 and they are phosphorylated in response to different types of TGF-beta ligands. Phosphorylated R-Smads can form complexes with Smad4 and  positively or negatively regulate transcription.\nThe Mad protein in Drosophila is the ortholog of Smad1/5, whereas dSmad2 is the ortholog of Smad2/3. In C. elegans, sma-2 and sma-3 proved to be homologous to Mad of Drosophila." [PubMed:16322555, PubMed:18061509, PubMed:9393997, PubMed:9880789]
exact_synonym: "receptor-activated Smad" []
exact_synonym: "receptor-regulated Smad" []
is_a: IMR:0000369 ! transcriptional regulator
is_a: IMR:0000370 ! Smad

[Term]
id: IMR:0000372
name: Co-Smad
def: "Co-Smad forms hetero-oligomers with R-Smads, which in turn translocate into the nucleus and regulate transcriptional responses.\nOnly Smad4 has been identified as a common-mediator Smad in vertebrates. A Smad4 homologue has been identified in Drosophila (Medea) and C. elegans (Sma-4)." [PubMed:16322555, PubMed:9393997]
exact_synonym: "co-mediator Smad" []
exact_synonym: "common Smad" []
exact_synonym: "common-mediator Smad" []
exact_synonym: "common-partner Smad" []
exact_synonym: "Smad4" []
is_a: IMR:0000369 ! transcriptional regulator
is_a: IMR:0000370 ! Smad

[Term]
id: IMR:0000373
name: I-Smad
def: "Smad6 and Smad7 are inhibitory Smads that serve as decoys interfering with Smad-receptor or Smad-Smad interactions. Inhibitory Smads have also been detected in Drosophila (Dad)." [PubMed:16322555, PubMed:9393997]
exact_synonym: "inhibitory Smad" []
is_a: IMR:0000370 ! Smad

[Term]
id: IMR:0000374
name: STAT
exact_synonym: "signal tranducers and activators of transcription" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000375
name: STAT1
def: "There are two STAT1 isoforms (STAT1alpha and STAT1beta) produced by alternative splicing of a single mRNA." [PubMed:1105043]
exact_synonym: "signal transducer and activator of transcription 1" []
is_a: IMR:0000374 ! STAT
relationship: part_of IMR:0001422 ! ISGF3
relationship: part_of IMR:0001423 ! GAF

[Term]
id: IMR:0000376
name: STAT2
exact_synonym: "signal transducer and activator of transcription 2" []
is_a: IMR:0000374 ! STAT
relationship: part_of IMR:0001422 ! ISGF3

[Term]
id: IMR:0000377
name: STAT3
exact_synonym: "signal transducer and activator of transcription 3" []
is_a: IMR:0000374 ! STAT

[Term]
id: IMR:0000378
name: STAT4
exact_synonym: "signal transducer and activator of transcription 4" []
is_a: IMR:0000374 ! STAT

[Term]
id: IMR:0000379
name: STAT5a
exact_synonym: "signal transducer and activator of transcription 5a" []
is_a: IMR:0100733 ! STAT5

[Term]
id: IMR:0000380
name: STAT5b
exact_synonym: "signal transducer and activator of transcription 5b" []
is_a: IMR:0100733 ! STAT5

[Term]
id: IMR:0000381
name: STAT6
exact_synonym: "signal transducer and activator of transcription 6" []
is_a: IMR:0000374 ! STAT

[Term]
id: IMR:0000382
name: NF-kappaB
def: "Members of this family include p50, p52, p65, c-Rel, v-Rrel, RelB, and the Drosophila proteins, Dorsal, Dif and Relish. Most of these transcription factors bind as homo- and heterodimers to the consensus a DNA sequence motif termed kappa-B." [IPR:000451]
exact_synonym: "NF-kappa-B" []
exact_synonym: "NFkB" []
exact_synonym: "nuclear factor-kappa B" []
exact_synonym: "Rel/NF-kappaB family" []
xref_analog: IPR:000451
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000383
name: Myc
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000384
name: Max
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000385
name: Mad
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000386
name: IRF family
exact_synonym: "interferon regulatory factor family" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000387
name: IRF-1
exact_synonym: "interferon regulatory factor-1" []
is_a: IMR:0000386 ! IRF family

[Term]
id: IMR:0000388
name: IRF-2
exact_synonym: "interferon regulatory factor-2" []
is_a: IMR:0000386 ! IRF family

[Term]
id: IMR:0000389
name: IRF-3
is_a: IMR:0000386 ! IRF family

[Term]
id: IMR:0000390
name: IRF-4
is_a: IMR:0000386 ! IRF family

[Term]
id: IMR:0000391
name: IRF-5
is_a: IMR:0000386 ! IRF family

[Term]
id: IMR:0000392
name: IRF-6
is_a: IMR:0000386 ! IRF family

[Term]
id: IMR:0000393
name: IRF-7
is_a: IMR:0000386 ! IRF family

[Term]
id: IMR:0000394
name: ICSBP
is_a: IMR:0000386 ! IRF family

[Term]
id: IMR:0000395
name: p48
exact_synonym: "IRF9" []
exact_synonym: "ISGF3 gamma" []
is_a: IMR:0000386 ! IRF family
relationship: part_of IMR:0001422 ! ISGF3

[Term]
id: IMR:0000396
name: DRTF1/E2F
def: "The members of two distinct families of proteins, DP and E2F, interact combinatorially as DP/E2F heterodimers in DRTF1/E2F transcription factor." [PubMed:7880534]
exact_synonym: "defferentiation-regulated transcription factor 1" []
exact_synonym: "E2 promoter binding factor" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000397
name: ets
exact_synonym: "E26 transformation-specific" []
xref_analog: IPR:000418
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000398
name: ERG
exact_synonym: "ets-related gene" []
is_a: IMR:0000397 ! ets

[Term]
id: IMR:0000399
name: ETS1
exact_synonym: "E26 transformation-specific1" []
is_a: IMR:0000397 ! ets

[Term]
id: IMR:0000400
name: ETS2
exact_synonym: "E26 transformation-specific2" []
is_a: IMR:0000397 ! ets

[Term]
id: IMR:0000401
name: WT1
exact_synonym: "Wilms' tumor protein" []
is_a: IMR:0000369 ! transcriptional regulator
is_a: IMR:0000424 ! transcriptional co-activator

[Term]
id: IMR:0000402
name: EGR family
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000403
name: EGR1
exact_synonym: "Krox24" []
exact_synonym: "NGFI-A" []
exact_synonym: "pAT225" []
exact_synonym: "TIS8" []
exact_synonym: "Zif268" []
is_a: IMR:0000402 ! EGR family

[Term]
id: IMR:0000404
name: EGR2
exact_synonym: "Krox20" []
exact_synonym: "pAT591" []
is_a: IMR:0000402 ! EGR family

[Term]
id: IMR:0000405
name: EGR3
is_a: IMR:0000402 ! EGR family

[Term]
id: IMR:0000406
name: EGR4
exact_synonym: "NGFI-C" []
exact_synonym: "pAT133" []
is_a: IMR:0000402 ! EGR family

[Term]
id: IMR:0000408
name: Myb
exact_synonym: "c-Myb" []
is_a: IMR:0000868 ! Myb family

[Term]
id: IMR:0000409
name: NF1
def: "The NFI family is composed of four members in vertebrates (NFI-A, NFI-B, NFI-C and NFI-X)." [PubMed:10831836]
exact_synonym: "CCAAT box-binding transcription factor" []
exact_synonym: "CTF" []
exact_synonym: "NFI" []
exact_synonym: "nuclear factor 1" []
xref_analog: IPR:000647
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000410
name: GATA
def: "GATA proteins, which control differentiation in a wide variety of cell types, may represent a class of factors that regulate early endoderm development throughout the animal kingdom." [PubMed:12221001]
exact_synonym: "GATA transcription factors" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000411
name: Maf
exact_synonym: "musculoaponeurotic fibrosarcoma" []
xref_analog: IPR:004826
is_a: IMR:0000369 ! transcriptional regulator
relationship: part_of IMR:0000414 ! AP-1

[Term]
id: IMR:0000412
name: PEBP2/CBF
def: "The PEBP2/CBF is a heterodimer  consists of DNA binding  alpha subunits and a beta subunit (CBFbeta) that does not bind DNA directly but that enhances the binding of the alpha subunit. Multiple alpha subunit genes, including CBFA1, AML1 (CBFA2), and CBFA3, have been detected.  All of the CBFalpha proteins contain a runt domain, which is similar to the Drosophila pair-rule gene, runt." [PubMed:9226149]
exact_synonym: "polyomavirus enhancer binding protein 2/core-binding factor" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000413
name: cytokeratin 17
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000414
name: AP-1
def: "The AP-1 (activator protein 1) transcription factor is a dimeric complex that comprises members of the JUN, FOS, ATF (activating transcription factor) and MAF (musculoaponeurotic fibrosarcoma) protein families. The AP-1 complex can therefore form many different combinations of heterodimers and homodimers, and this combination determines the genes that are regulated by AP-1." [PubMed:14668816]
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000415
name: FOS
xref_analog: IPR:000837
is_a: IMR:0000369 ! transcriptional regulator
relationship: part_of IMR:0000414 ! AP-1

[Term]
id: IMR:0000416
name: JUN
xref_analog: IPR:002112
is_a: IMR:0000369 ! transcriptional regulator
relationship: part_of IMR:0000414 ! AP-1

[Term]
id: IMR:0000417
name: BCL-6
def: "BCL-6 belongs to a subset of transcription factors which all have a similar structure composed of an amino-terminal 'POZ' domain and several zinc finger modules at the carboxy-terminus. BCL-6 is highly conserved among vertebrate species. BCL-6 homologues have been identified from human, mouse, frog, and chicken species." [PubMed:11796228]
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000418
name: TCF/LEF-1 family
exact_synonym: "T-cell factor/lymphoid-enhancer factor" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000419
name: PRDII-BF1
exact_synonym: "binding factor of PRDII (positive regulatory domainII of the human IFN-beta gene promoter)" []
exact_synonym: "HIV-EP1" []
exact_synonym: "MBP1" []
exact_synonym: "Shn-1" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000420
name: CREB
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000421
name: NF-AT
def: "NFAT proteins are a family of transcription factors (NFATC1~C4) whose activation is controlled by calcineurin, a Ca2+-dependent phosphatase. " [PubMed:11877454, PubMed:11983154]
exact_synonym: "Nuclear factor of activated T-cells" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000422
name: C/EBP
exact_synonym: "CCAAT/enhancer binding protein" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000423
name: transcriptional cofactor
xref_analog: GO:0003712
is_a: IMR:0000368 ! transcription factor

[Term]
id: IMR:0000424
name: transcriptional co-activator
xref_analog: GO:0003713
is_a: IMR:0000423 ! transcriptional cofactor

[Term]
id: IMR:0000425
name: Tax
exact_synonym: "transcriptional trans-activator coded in X-region" []
is_a: IMR:0000424 ! transcriptional co-activator

[Term]
id: IMR:0000426
name: p300/CBP
is_a: IMR:0000424 ! transcriptional co-activator
is_a: IMR:0001176 ! histone acetyltransferase

[Term]
id: IMR:0000427
name: transcription co-repressor
xref_analog: GO:0003714
is_a: IMR:0000423 ! transcriptional cofactor

[Term]
id: IMR:0000428
name: signal regulator
def: "A signaling protein which positively/negatively regulates a signal transduction pathway." [INOH:SY]
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000429
name: enzyme regulator
xref_analog: GO:0030234
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000430
name: RGS family
comment: This term was made obsolete. To update annotations, consider the term 'IMR0000431:RGS'.
exact_synonym: "regulator of G protein signaling family" []
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0000431
name: RGS
def: "RGS proteins act as negative regulators of G protein dependent signaling, at least in part, because they stimulate hydrolysis of the GTP bound to activated G alpha subunits." [PubMed:9064301]
exact_synonym: "regulator of G protein signaling" []
xref_analog: GO:0016299
is_a: IMR:0000429 ! enzyme regulator

[Term]
id: IMR:0000432
name: Axin
exact_synonym: "Axin/conductin" []
is_a: IMR:0000333 ! adaptor protein
is_a: IMR:0001160 ! negative regulator of Wnt signaling pathway

[Term]
id: IMR:0000433
name: GEF
exact_synonym: "guanine nucleotide exchange factor" []
xref_analog: GO:0005085
is_a: IMR:0000429 ! enzyme regulator

[Term]
id: IMR:0000434
name: Vav
is_a: IMR:0001954 ! RhoGEF

[Term]
id: IMR:0000435
name: Sos
def: "Drosophila Son of Sevenless (SOS) is homologous to the yeast exchange factor for Ras, CDC25. Mammalian cells contain two closely related homologs of Drosophila SOS: SOS1 and SOS2. Biochemical studies have established that SOS indeed functions as a guanine nucleotide exchange factor for Ras." [UniProt:12177507]
exact_synonym: "son of sevenless" []
is_a: IMR:0100440 ! RasGEF

[Term]
id: IMR:0000436
name: C3G
exact_synonym: "Crk SH3 domein binding GEF" []
exact_synonym: "Guanine nucleotide-releasing factor 2" []
is_a: IMR:0100440 ! RasGEF

[Term]
id: IMR:0000437
name: Dbl
is_a: IMR:0001954 ! RhoGEF

[Term]
id: IMR:0000438
name: cytohesin
is_a: IMR:0000433 ! GEF

[Term]
id: IMR:0000439
name: RalGEF
exact_synonym: "Ral guanine nucleotide exchange factor" []
xref_analog: GO:0008321
is_a: IMR:0100440 ! RasGEF

[Term]
id: IMR:0000440
name: RasGRF
is_a: IMR:0100440 ! RasGEF

[Term]
id: IMR:0000441
name: TAB1
exact_synonym: "TAK1 binding protein 1" []
is_a: IMR:0002665 ! TAB

[Term]
id: IMR:0000442
name: GAP
exact_synonym: "GTPase activating protein" []
xref_analog: GO:0005096
is_a: IMR:0000429 ! enzyme regulator

[Term]
id: IMR:0000443
name: Ras GAP
exact_synonym: "Ras GTPase-activating protein" []
xref_analog: GO:0005099
is_a: IMR:0000442 ! GAP

[Term]
id: IMR:0000444
name: GDI
exact_synonym: "GDP-dissociation inhibitor" []
exact_synonym: "guanine nucleotide dissociation inhibitor" []
xref_analog: GO:0005092
is_a: IMR:0000429 ! enzyme regulator

[Term]
id: IMR:0000445
name: CKI
exact_synonym: "cyclin-dependent kinase inhibitor" []
exact_synonym: "cyclin-dependent protein kinase inhibitor" []
xref_analog: GO:0004861
is_a: IMR:0000429 ! enzyme regulator

[Term]
id: IMR:0000446
name: Cip/Kip family
is_a: IMR:0000445 ! CKI

[Term]
id: IMR:0000447
name: INK4 family
is_a: IMR:0000445 ! CKI

[Term]
id: IMR:0000448
name: Noggin
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000449
name: sina/siah
exact_synonym: "seven in absentia/sina homolog" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000450
name: apoptosis regulator
xref_analog: GO:0016329
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000451
name: Bcl-2 family
def: "The Bcl-2 family consists of about 20 homologues of important pro- and anti-apoptotic regulators of programmed cell death." [PubMed:14634621, PubMed:14996506]
exact_synonym: "B cell lymphoma/leukemia-2 family" []
is_a: IMR:0000450 ! apoptosis regulator

[Term]
id: IMR:0000452
name: BAK
is_a: IMR:0100708 ! Bax subfamily

[Term]
id: IMR:0000453
name: BAX
is_a: IMR:0100708 ! Bax subfamily

[Term]
id: IMR:0000454
name: IAP-family
exact_synonym: "inhibitor of apoptosis-family" []
is_a: IMR:0000450 ! apoptosis regulator

[Term]
id: IMR:0000455
name: IAP (DROME)
comment: This term was made obsolete. To update annotations, consider the term 'IMR0000454:IAP-family'.
exact_synonym: "inhibitor of apoptosis protein" []
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0000456
name: 14-3-3
def: "The term 14-3-3 denotes a large family of ~30 kDa acidic proteins that exist primarily as homo- and heterodimers within all eukaryotic cells. Their unusual name refers to their elution position on DEAE-cellulose chromatography and gel electrophoresis during a systematic attempt at classifying bovine brain proteins. In humans, there are seven distinct 14-3-3 genes denoted beta, gamma, epsilon, eta, sigma, tau (theta) and zeta (as well as a number of potential pseudogenes), while yeast and plants contain between 2 and 15 genes." [PubMed:11911880]
xref_analog: IPR:000308
is_a: IMR:0000428 ! signal regulator
is_a: IMR:0001160 ! negative regulator of Wnt signaling pathway

[Term]
id: IMR:0000457
name: calmodulin
alt_id: IMR:0010172
exact_synonym: "CALM" []
exact_synonym: "Calmodulin" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000458
name: cytokeratin 18
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000459
name: cytokeratin 19
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000460
name: SOCS
exact_synonym: "CIS" []
exact_synonym: "Cytokine-inducible SH2 protein" []
exact_synonym: "SSI" []
exact_synonym: "STAT induced STAT inhibitor" []
exact_synonym: "Suppressor of cytokine signaling" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000461
name: pRB
exact_synonym: "Retinoblastoma protein" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000462
name: TRAF family
exact_synonym: "TNF receptor associated factor family" []
is_a: IMR:0000333 ! adaptor protein

[Term]
id: IMR:0000463
name: I-kappaB family
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000464
name: I-kappaB
exact_synonym: "IkB" []
exact_synonym: "inhibitor of NF-kappaB" []
is_a: IMR:0000463 ! I-kappaB family

[Term]
id: IMR:0000465
name: antigen
def: "Molecule that is able to provoke an immune response." [ISBN:0815340729]
is_a: IMR:0000002 ! ligand

[Term]
id: IMR:0000466
name: cytokeratin 20
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000467
name: cytokeratin 23
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000469
name: cytokeratin 6
is_a: IMR:0000050 ! type II cytokeratin

[Term]
id: IMR:0000470
name: K2C6A_MOUSE
exact_synonym: "CK-6A" [UniProt:P50446]
exact_synonym: "Cytokeratin-6A" [UniProt:P50446]
exact_synonym: "K6A" [UniProt:P50446]
exact_synonym: "Ker2" [UniProt:P50446]
exact_synonym: "keratin 6A" [MGI:1100845]
exact_synonym: "Keratin, type II cytoskeletal 6A" [UniProt:P50446]
exact_synonym: "Keratin-6-alpha" [UniProt:P50446]
exact_synonym: "Keratin-6A" [UniProt:P50446]
exact_synonym: "Krt2-6" [UniProt:P50446]
exact_synonym: "Krt2-6a" [MGI:1100845, UniProt:P50446]
exact_synonym: "Krt2-6c" [MGI:1100845]
exact_synonym: "Krt6" [UniProt:P50446]
exact_synonym: "Krt6a" [MGI:1100845, UniProt:P50446]
exact_synonym: "mK6-alpha" [UniProt:P50446]
exact_synonym: "mK6[a]" [MGI:1100845]
exact_synonym: "MK6a" [MGI:1100845]
xref_analog: UniProt:P50446
relationship: sequence_of IMR:0000165 ! cytokeratin 6A

[Term]
id: IMR:0000471
name: cytokeratin 21
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000472
name: NF-H
is_a: IMR:0000203 ! neurofilament protein

[Term]
id: IMR:0000473
name: CD28
def: "CD28 is an integral membrane protein homodimer, the extracellular region of which contains one immunoglobulin-like domain. In human T cells, CD28 and the T-cell receptor (TCR) are expressed at ~6  104 and ~2  104 molecules per cell, respectively.CD28 is expressed by most mouse T cells, 90% of human CD4+ T cells and 50% of human CD8+ T cells." [PubMed:14647476]
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000474
name: NF-L
is_a: IMR:0000203 ! neurofilament protein

[Term]
id: IMR:0000475
name: NF-M
is_a: IMR:0000203 ! neurofilament protein

[Term]
id: IMR:0000477
name: actin cross linking protein
exact_synonym: "actin bundling protein" []
is_a: IMR:0000188 ! microfilament cytoskeletal protein

[Term]
id: IMR:0000478
name: fimbrin
is_a: IMR:0000477 ! actin cross linking protein

[Term]
id: IMR:0000479
name: alpha-actinin 1
is_a: IMR:0000189 ! alpha-actinin

[Term]
id: IMR:0000480
name: chloride channel
xref_analog: GO:0005254
is_a: IMR:0000482 ! anion channel

[Term]
id: IMR:0000481
name: ion channel
xref_analog: GO:0005216
is_a: IMR:0000655 ! channel

[Term]
id: IMR:0000482
name: anion channel
xref_analog: GO:0005253
is_a: IMR:0000481 ! ion channel

[Term]
id: IMR:0000483
name: alpha-actinin 2
is_a: IMR:0000189 ! alpha-actinin

[Term]
id: IMR:0000484
name: alpha-actinin 3
is_a: IMR:0000189 ! alpha-actinin

[Term]
id: IMR:0000485
name: alpha-actinin 4
is_a: IMR:0000189 ! alpha-actinin

[Term]
id: IMR:0000486
name: beta-actin
exact_synonym: "cytoplasmic actin" []
is_a: IMR:0000190 ! actin

[Term]
id: IMR:0000487
name: alpha-cardiac actin
exact_synonym: "cardiac muscle actin" []
is_a: IMR:0000490 ! alpha-actin

[Term]
id: IMR:0000488
name: gamma-actin
is_a: IMR:0000190 ! actin

[Term]
id: IMR:0000489
name: alpha-actin 1
exact_synonym: "skeletal muscle alpha-actin" []
is_a: IMR:0000490 ! alpha-actin

[Term]
id: IMR:0000490
name: alpha-actin
is_a: IMR:0000190 ! actin

[Term]
id: IMR:0000491
name: alpha-actin 3
exact_synonym: "gamma-actin 2" []
exact_synonym: "gamma-enteric actin" []
exact_synonym: "smooth muscle (enteric type) gamma-actin" []
exact_synonym: "smooth muscle gamma-actin" []
is_a: IMR:0000490 ! alpha-actin

[Term]
id: IMR:0000492
name: alpha-actin 2
exact_synonym: "smooth muscle alpha-actin (aortic type)" []
is_a: IMR:0000490 ! alpha-actin

[Term]
id: IMR:0000494
name: microfilament protein
exact_synonym: "actin filament protein" []
xref_analog: GO:0005884
is_a: IMR:0000188 ! microfilament cytoskeletal protein

[Term]
id: IMR:0000495
name: microtubule protein
xref_analog: GO:0005874
is_a: IMR:0000196 ! microtubule cytoskeletal protein

[Term]
id: IMR:0000496
name: intermediate filament protein
xref_analog: GO:0005882
is_a: IMR:0000201 ! intermediate filament cytoskeletal protein

[Term]
id: IMR:0000497
name: sodium channel
xref_analog: GO:0005272
is_a: IMR:0000498 ! cation channel

[Term]
id: IMR:0000498
name: cation channel
xref_analog: GO:0005261
is_a: IMR:0000481 ! ion channel

[Term]
id: IMR:0000499
name: calcium channel
xref_analog: GO:0005262
is_a: IMR:0000498 ! cation channel

[Term]
id: IMR:0000500
name: potassium channel
xref_analog: GO:0005267
is_a: IMR:0000498 ! cation channel

[Term]
id: IMR:0000501
name: Ca2+-sensitive potassium channel
exact_synonym: "Calcium-activated potassium channel" []
xref_analog: GO:0015269
is_a: IMR:0000500 ! potassium channel
is_a: IMR:0000746 ! intracellular ligand-gated ion channel

[Term]
id: IMR:0000502
name: inward rectifier potassium channel
exact_synonym: "Kir" []
xref_analog: GO:0005242
is_a: IMR:0000500 ! potassium channel

[Term]
id: IMR:0000503
name: Kir1
is_a: IMR:0000502 ! inward rectifier potassium channel

[Term]
id: IMR:0000504
name: Kir1.1
is_a: IMR:0000503 ! Kir1

[Term]
id: IMR:0000505
name: Kir2
is_a: IMR:0000502 ! inward rectifier potassium channel

[Term]
id: IMR:0000506
name: Kir2.1
is_a: IMR:0000505 ! Kir2

[Term]
id: IMR:0000507
name: Kir2.2
def: "The inwardly rectifying K+ (Kir) channel subunits, Kir2.2 (hKir2.2) and its variant, termed hKir2.2v have been identified in human genome." [PubMed:8647284]
is_a: IMR:0000505 ! Kir2

[Term]
id: IMR:0000508
name: Kir3
is_a: IMR:0000502 ! inward rectifier potassium channel

[Term]
id: IMR:0000509
name: Kir5
is_a: IMR:0000502 ! inward rectifier potassium channel

[Term]
id: IMR:0000510
name: Kir6
is_a: IMR:0000502 ! inward rectifier potassium channel

[Term]
id: IMR:0000511
name: Kir7
is_a: IMR:0000502 ! inward rectifier potassium channel

[Term]
id: IMR:0000512
name: kinase
xref_analog: EC:2.7.-.-
xref_analog: GO:0016301
is_a: IMR:0010050 ! transferase

[Term]
id: IMR:0000513
name: voltage-gated potassium channel
xref_analog: GO:0005249
is_a: IMR:0000500 ! potassium channel
is_a: IMR:0100584 ! voltage-gated ion channel

[Term]
id: IMR:0000515
name: caveolin
is_a: IMR:0000333 ! adaptor protein

[Term]
id: IMR:0000516
name: clathrin
is_a: IMR:0000654 ! vesicular transport protein

[Term]
id: IMR:0000517
name: phosphatase
exact_synonym: "phosphoric monoester hydrolase activity" []
xref_analog: EC:3.1.3.-
xref_analog: GO:0016791
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0000518
name: motor protein
exact_synonym: "molecular motor" []
xref_analog: GO:0003774
is_a: IMR:0000185 ! cytoskeletal protein

[Term]
id: IMR:0000519
name: Kv
def: "The Kv family can be divided into 4 subfamilies on the basis of sequence similarity and function: Shaker (Kv1), Shab (Kv2), Shaw (Kv3) and Shal (Kv4)." [ISBN:0121844536]
xref_analog: IPR:003968
is_a: IMR:0000513 ! voltage-gated potassium channel

[Term]
id: IMR:0000520
name: arrestin
is_a: IMR:0000950 ! cellular structure protein

[Term]
id: IMR:0000522
name: Aquaporin
is_a: IMR:0000656 ! water channel

[Term]
id: IMR:0000523
name: COP I vesicle protein
is_a: IMR:0000654 ! vesicular transport protein

[Term]
id: IMR:0000524
name: Kv1-Shaker
def: "Vertebrate K+ channel subunits whose primary amino acid sequences are most closely related to those of Drosophila Shaker are grouped in the voltage-gated K+ channel subfamily 1 (Kv1)." [ISBN:0121844536]
xref_analog: IPR:003972
is_a: IMR:0000519 ! Kv

[Term]
id: IMR:0000525
name: coatomer protein complex
xref_analog: GO:0030126
is_a: IMR:0000523 ! COP I vesicle protein

[Term]
id: IMR:0000526
name: connexin
is_a: IMR:0000950 ! cellular structure protein

[Term]
id: IMR:0000527
name: Kv1.1
is_a: IMR:0000524 ! Kv1-Shaker

[Term]
id: IMR:0000528
name: Kv1.2
is_a: IMR:0000524 ! Kv1-Shaker

[Term]
id: IMR:0000529
name: Kv1.3
is_a: IMR:0000524 ! Kv1-Shaker

[Term]
id: IMR:0000530
name: Kv1.4
is_a: IMR:0000524 ! Kv1-Shaker

[Term]
id: IMR:0000531
name: Kv1.5
is_a: IMR:0000524 ! Kv1-Shaker

[Term]
id: IMR:0000532
name: Kv1.6
is_a: IMR:0000524 ! Kv1-Shaker

[Term]
id: IMR:0000533
name: Kv2-Shab
def: "Vertebrate K+ channel subunits whose primary amino acid sequences are most closely related to those of Drosophila Shab are grouped in the voltage-gated K+ channel subfamily 2 (Kv2)." [ISBN:0121844536]
xref_analog: IPR:003973
is_a: IMR:0000519 ! Kv

[Term]
id: IMR:0000534
name: Kv2.1
is_a: IMR:0000533 ! Kv2-Shab

[Term]
id: IMR:0000535
name: myelin protein
is_a: IMR:0000950 ! cellular structure protein

[Term]
id: IMR:0000537
name: Kv2.2
is_a: IMR:0000533 ! Kv2-Shab

[Term]
id: IMR:0000538
name: Kv3-Shaw
def: "Vertebrate K+ channel subunits whose primary amino acid sequences are most closely related to those of Drosophila Shaw are grouped in the voltage-gated K+ channel subfamily 3 (Kv3)." [ISBN:0121844536]
xref_analog: IPR:003974
is_a: IMR:0000519 ! Kv

[Term]
id: IMR:0000540
name: extracellular matrix protein
exact_synonym: "ECM protein" []
xref_analog: GO:0005201
xref_analog: GO:0005578
is_a: IMR:0000950 ! cellular structure protein

[Term]
id: IMR:0000541
name: collagen
xref_analog: GO:0005581
is_a: IMR:0000540 ! extracellular matrix protein

[Term]
id: IMR:0000542
name: fibrillar collagen
def: "Types I, II and III collagens constitute the classical fibrillar collagens and account for 80-90% of all the collagen in the body. Types V and XI collagens are also classified as fibrillar collagens on the basis of thier homology with types I-III collagens." [ISBN:0120689111]
exact_synonym: "fibrillar forming collagen" []
xref_analog: GO:0005583
is_a: IMR:0000541 ! collagen

[Term]
id: IMR:0000544
name: fibril-associated collagen
def: "associate with the surface of fibrils and modify their interactive properties." [ISBN:0120689111]
exact_synonym: "FACIT collagen" []
exact_synonym: "fibril associated collagens with interrupted triple helix" []
xref_analog: GO:0005593
is_a: IMR:0000541 ! collagen

[Term]
id: IMR:0000546
name: fibronectin
is_a: IMR:0000540 ! extracellular matrix protein

[Term]
id: IMR:0000547
name: elastin
is_a: IMR:0000540 ! extracellular matrix protein

[Term]
id: IMR:0000548
name: tenascin
is_a: IMR:0000540 ! extracellular matrix protein

[Term]
id: IMR:0000549
name: Kv3.1
is_a: IMR:0000538 ! Kv3-Shaw

[Term]
id: IMR:0000550
name: Kv3.2
is_a: IMR:0000538 ! Kv3-Shaw

[Term]
id: IMR:0000551
name: type IV collagen
xref_analog: GO:0005587
is_a: IMR:0001124 ! basement membrane collagen

[Term]
id: IMR:0000552
name: proteoglycan
def: "Proteoglycans are a diverse family of molecules characterized by a core protein to which is attached one or more glycosaminoglycan (GAG) side-chains." [ISBN:0120689111]
is_a: IMR:0000540 ! extracellular matrix protein

[Term]
id: IMR:0000553
name: Kv3.3
is_a: IMR:0000538 ! Kv3-Shaw

[Term]
id: IMR:0000554
name: laminin family
is_a: IMR:0000540 ! extracellular matrix protein

[Term]
id: IMR:0000555
name: kalinin
is_a: IMR:0000554 ! laminin family

[Term]
id: IMR:0000556
name: unclassified protein
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000557
name: nucleophosmin
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0000558
name: disabled
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0000559
name: GADD45
def: "The MyD118/CR6/Gadd45 gene family (also termed Gadd45b, Gadd45g, Gadd45a) encodes for small (18 kd), evolutionary conserved proteins that are highly homologous to each other (55 57% overall identity at the amino acid level), are highly acidic (pI=4.0  4.2), and are primarily localized within the cell nucleus. MyD118/CR6/GADD45 serve similar, but not identical, functions along different apoptotic and growth inhibitory pathways. They interact with cell cycle proteins." [PubMed:12032777]
exact_synonym: "growth arrest and DNA damage inducible 45" []
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0000560
name: presenilin
is_a: IMR:0000304 ! protease
relationship: part_of IMR:0001882 ! gamma-secretase complex

[Term]
id: IMR:0000561
name: Kv3.4
is_a: IMR:0000538 ! Kv3-Shaw

[Term]
id: IMR:0000562
name: Kv4-Shal
def: "Vertebrate K+ channel subunits whose primary amino acid sequences are most closely related to those of Drosophila Shal are grouped in the voltage-gated K+ channel subfamily 4 (Kv4)." [ISBN:0121844536]
xref_analog: IPR:003975
is_a: IMR:0000519 ! Kv

[Term]
id: IMR:0000563
name: Kv4.1
is_a: IMR:0000562 ! Kv4-Shal

[Term]
id: IMR:0000564
name: Kv4.2
is_a: IMR:0000562 ! Kv4-Shal

[Term]
id: IMR:0000565
name: Kv4.3
is_a: IMR:0000562 ! Kv4-Shal

[Term]
id: IMR:0000566
name: Dok1
alt_id: IMR:0010219
alt_id: IMR:0011551
exact_synonym: "a p62 rasGAP-associated protein" []
exact_synonym: "Downstream of tyrosine kinase 1" []
is_a: IMR:0000346 ! Dok

[Term]
id: IMR:0000567
name: Dok2
exact_synonym: "dok-R" []
exact_synonym: "Downstream of tyrosine kinase 2" []
exact_synonym: "FRIP" []
is_a: IMR:0000346 ! Dok

[Term]
id: IMR:0000568
name: P-cadherin
exact_synonym: "cadherin-3" []
exact_synonym: "Placental-cadherin" []
is_a: IMR:0000167 ! cadherin

[Term]
id: IMR:0000569
name: K-cadherin
exact_synonym: "cadherin-6" []
exact_synonym: "Kidney-cadherin" []
is_a: IMR:0000167 ! cadherin

[Term]
id: IMR:0000570
name: ponsin-1
is_a: IMR:0000184 ! ponsin

[Term]
id: IMR:0000571
name: ponsin-2
is_a: IMR:0000184 ! ponsin

[Term]
id: IMR:0000572
name: IFN alpha-1
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000573
name: IFN alpha-2
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000574
name: IFN alpha-4
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000575
name: IFN alpha-5
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000576
name: IFN alpha-6
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000577
name: IFN alpha-7
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000578
name: IFN alpha-8
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000579
name: IFN alpha-9
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000580
name: IFN alpha-10
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000581
name: IFN alpha-14
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000582
name: IFN alpha-16
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000583
name: IFN alpha-17
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000584
name: IFN alpha-21
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000585
name: IL-4
exact_synonym: "interleukin-4" []
xref_analog: GO:0005136
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000586
name: IL-7
exact_synonym: "interleukin-7" []
xref_analog: GO:0005139
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000587
name: IL-8
exact_synonym: "interleukin-8" []
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000588
name: IL-9
exact_synonym: "interleukin-9" []
xref_analog: GO:0005140
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000589
name: IL-10
exact_synonym: "interleukin-10" []
xref_analog: GO:0005141
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000590
name: IL-12
exact_synonym: "interleukin-12" []
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000591
name: IL-12A
exact_synonym: "interleukin-12 alpha chain" []
exact_synonym: "p35" []
relationship: part_of IMR:0000590 ! IL-12

[Term]
id: IMR:0000592
name: IL-12B
exact_synonym: "interleukin-12 beta chain" []
exact_synonym: "p40" []
relationship: part_of IMR:0000590 ! IL-12
relationship: part_of IMR:0002716 ! IL-23

[Term]
id: IMR:0000593
name: IL-1RI : IL-1R AcP
is_a: IMR:0000120 ! IL-1 receptor

[Term]
id: IMR:0000594
name: IL-1RII : IL-1R AcP
is_a: IMR:0000120 ! IL-1 receptor

[Term]
id: IMR:0000595
name: IL-13
exact_synonym: "interleukin-13" []
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000596
name: IL-14
exact_synonym: "High molecular weight B-cell growth factor" []
exact_synonym: "interleukin-14" []
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000597
name: IL-15
exact_synonym: "interleukin-15" []
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000598
name: IL-16
exact_synonym: "interleukin-16" []
exact_synonym: "LCF" []
exact_synonym: "lymphocyte chemoattractant factor" []
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000599
name: IL-17
exact_synonym: "CTLA-8" []
exact_synonym: "cytotoxic T lymphocyte-associated antigen 8" []
exact_synonym: "interleukin-17" []
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000600
name: IL-17 receptor
exact_synonym: "interleukin-17 receptor" []
xref_analog: GO:0030368
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000601
name: IL-18
exact_synonym: "interleukin-18" []
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000602
name: IL-12 receptor
exact_synonym: "interleukin-12 receptor" []
xref_analog: GO:0016517
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000603
name: IL-12R-beta1
exact_synonym: "interleukin-12 receptor beta-1" []
relationship: part_of IMR:0000602 ! IL-12 receptor
relationship: part_of IMR:0002717 ! IL-23 receptor

[Term]
id: IMR:0000604
name: IL-12R-beta2
exact_synonym: "interleukin-12 receptor beta-2" []
relationship: part_of IMR:0000602 ! IL-12 receptor

[Term]
id: IMR:0000605
name: IL-8 receptor
exact_synonym: "interleukin-8 receptor" []
xref_analog: GO:0004918
is_a: IMR:0000096 ! interleukin receptor
is_a: IMR:0000137 ! G-Protein Coupled Receptor

[Term]
id: IMR:0000606
name: IL-8RA
exact_synonym: "interleukin-8 receptor A" []
is_a: IMR:0000605 ! IL-8 receptor

[Term]
id: IMR:0000607
name: IL-8RB
exact_synonym: "interleukin-8 receptor B" []
is_a: IMR:0000605 ! IL-8 receptor

[Term]
id: IMR:0000608
name: IL-10 receptor
exact_synonym: "interleukin-10 receptor" []
xref_analog: GO:0004920
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000609
name: IL-10R1
exact_synonym: "IL-10RA" []
exact_synonym: "interleukin-10 receptor alpha" []
relationship: part_of IMR:0000608 ! IL-10 receptor

[Term]
id: IMR:0000610
name: IL-10R2
exact_synonym: "IL-10RB" []
exact_synonym: "interleukin-10 receptor beta" []
relationship: part_of IMR:0000608 ! IL-10 receptor

[Term]
id: IMR:0000611
name: IL-11 receptor
xref_analog: GO:0004921
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000612
name: IL-11RA2
exact_synonym: "interleukin-11 receptor alpha chain 2" []
exact_synonym: "interleukin-11 receptor beta chain" []
relationship: part_of IMR:0000611 ! IL-11 receptor

[Term]
id: IMR:0000613
name: IL-11RA1
exact_synonym: "interleukin-11 receptor alpha chain 1" []
relationship: part_of IMR:0000611 ! IL-11 receptor

[Term]
id: IMR:0000614
name: neuregulin-1
exact_synonym: "NRG-1" []
is_a: IMR:0000048 ! neuregulin

[Term]
id: IMR:0000615
name: neuregulin-2
exact_synonym: "NRG-2" []
is_a: IMR:0000048 ! neuregulin

[Term]
id: IMR:0000616
name: neuregulin-3
exact_synonym: "NRG-3" []
is_a: IMR:0000048 ! neuregulin

[Term]
id: IMR:0000617
name: neuregulin-4
exact_synonym: "NRG-4" []
is_a: IMR:0000048 ! neuregulin

[Term]
id: IMR:0000618
name: ICAM-1
exact_synonym: "intercellular adhesion molecule 1" []
is_a: IMR:0000178 ! ICAM

[Term]
id: IMR:0000619
name: ICAM-2
exact_synonym: "intercellular adhesion molecule 2" []
is_a: IMR:0000178 ! ICAM

[Term]
id: IMR:0000620
name: ICAM-3
exact_synonym: "intercellular adhesion molecule 3" []
is_a: IMR:0000178 ! ICAM

[Term]
id: IMR:0000621
name: ICAM-4
exact_synonym: "intercellular adhesion molecule 4" []
is_a: IMR:0000178 ! ICAM

[Term]
id: IMR:0000622
name: ICAM-5
exact_synonym: "intercellular adhesion molecule 5" []
is_a: IMR:0000178 ! ICAM

[Term]
id: IMR:0000623
name: Integrin alpha-1
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000624
name: Integrin alpha-2
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000625
name: Integrin alpha-3
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000626
name: Integrin alpha-4
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000627
name: Integrin alpha-5
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000628
name: Integrin alpha-6
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000629
name: Integrin alpha-7
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000630
name: Integrin alpha-8
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000631
name: Integrin alpha-9
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000632
name: Integrin alpha-10
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000633
name: Integrin alpha-11
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000634
name: Integrin alpha-IIb
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000635
name: Integrin alpha-D
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000636
name: Integrin alpha-E
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000637
name: Integrin alpha-L
is_a: IMR:0000173 ! Integrin alpha
relationship: part_of IMR:0000650 ! LFA-1

[Term]
id: IMR:0000638
name: Integrin alpha-M
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000639
name: Integrin alpha-V
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000640
name: Integrin alpha-X
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000641
name: Integrin beta-1
is_a: IMR:0000174 ! Integrin beta

[Term]
id: IMR:0000642
name: Integrin beta-2
is_a: IMR:0000174 ! Integrin beta
relationship: part_of IMR:0000650 ! LFA-1

[Term]
id: IMR:0000643
name: Integrin beta-3
is_a: IMR:0000174 ! Integrin beta

[Term]
id: IMR:0000644
name: Integrin beta-4
is_a: IMR:0000174 ! Integrin beta

[Term]
id: IMR:0000645
name: Integrin beta-5
is_a: IMR:0000174 ! Integrin beta

[Term]
id: IMR:0000646
name: Integrin beta-6
is_a: IMR:0000174 ! Integrin beta

[Term]
id: IMR:0000647
name: Integrin beta-7
is_a: IMR:0000174 ! Integrin beta

[Term]
id: IMR:0000648
name: Integrin beta-8
is_a: IMR:0000174 ! Integrin beta

[Term]
id: IMR:0000649
name: CD44
is_a: IMR:0001125 ! heparan sulfate proteoglycan

[Term]
id: IMR:0000650
name: LFA-1
is_a: IMR:0000166 ! adhesion molecule

[Term]
id: IMR:0000651
name: 1-acylglycerol-3-phosphate
exact_synonym: "1-acyl-sn-glycerol-3-phosphate" []
xref_analog: KEGG:C00681
is_a: IMR:0100182 ! LPA

[Term]
id: IMR:0000652
name: 2-acylglycerol-3-phosphate
exact_synonym: "2-acyl-sn-glycerol-3-phosphate" []
xref_analog: KEGG:C03974
is_a: IMR:0100182 ! LPA

[Term]
id: IMR:0000653
name: nucleocytoplasmic transport protein
xref_analog: GO:0005487
is_a: IMR:0100009 ! intracellular transport protein

[Term]
id: IMR:0000654
name: vesicular transport protein
is_a: IMR:0100009 ! intracellular transport protein

[Term]
id: IMR:0000655
name: channel
def: "Forms a water-filled pore across the bilayer through which specific solute can diffuse." [ISBN:0815340729]
xref_analog: GO:0015267
is_a: IMR:0001049 ! membrane transport protein

[Term]
id: IMR:0000656
name: water channel
xref_analog: GO:0015250
is_a: IMR:0000655 ! channel

[Term]
id: IMR:0000657
name: alpha-COP
exact_synonym: "coatomer alpha subunit" []
relationship: part_of IMR:0000525 ! coatomer protein complex

[Term]
id: IMR:0000658
name: beta-COP
exact_synonym: "coatomer beta subunit" []
relationship: part_of IMR:0000525 ! coatomer protein complex

[Term]
id: IMR:0000659
name: delta-COP
exact_synonym: "coatomer delta subunit" []
relationship: part_of IMR:0000525 ! coatomer protein complex

[Term]
id: IMR:0000660
name: epsilon-COP
exact_synonym: "coatomer epsilon subunit" []
relationship: part_of IMR:0000525 ! coatomer protein complex

[Term]
id: IMR:0000661
name: gamma-COP
exact_synonym: "coatomer gamma subunit" []
relationship: part_of IMR:0000525 ! coatomer protein complex

[Term]
id: IMR:0000662
name: beta'-COP
exact_synonym: "Coatomer beta' subunit" []
relationship: part_of IMR:0000525 ! coatomer protein complex

[Term]
id: IMR:0000663
name: zeta-COP
exact_synonym: "Coatomer zeta subunit" []
relationship: part_of IMR:0000525 ! coatomer protein complex

[Term]
id: IMR:0000664
name: zeta-1 COP
exact_synonym: "Coatomer zeta-1 subunit" []
is_a: IMR:0000663 ! zeta-COP

[Term]
id: IMR:0000665
name: zeta-2 COP
exact_synonym: "Coatomer zeta-2 subunit" []
is_a: IMR:0000663 ! zeta-COP

[Term]
id: IMR:0000666
name: ezrin
is_a: IMR:0000186 ! ERM family

[Term]
id: IMR:0000667
name: moesin
is_a: IMR:0000186 ! ERM family

[Term]
id: IMR:0000668
name: radixin
is_a: IMR:0000186 ! ERM family

[Term]
id: IMR:0000669
name: PAK2
is_a: IMR:0000238 ! PAK

[Term]
id: IMR:0000670
name: PAK3
is_a: IMR:0000238 ! PAK

[Term]
id: IMR:0000671
name: PAK4
is_a: IMR:0000238 ! PAK

[Term]
id: IMR:0000672
name: PAK6
exact_synonym: "PAK5" []
is_a: IMR:0000238 ! PAK

[Term]
id: IMR:0000673
name: PAK7
exact_synonym: "PAK5" []
is_a: IMR:0000238 ! PAK

[Term]
id: IMR:0000674
name: A-Raf
is_a: IMR:0000231 ! Raf

[Term]
id: IMR:0000675
name: B-Raf
is_a: IMR:0000231 ! Raf

[Term]
id: IMR:0000676
name: cGMP-dependent protein kinase I
alt_id: IMR:0000678
exact_synonym: "type I alpha cGMP-dependent protein kinase" []
exact_synonym: "type I beta cGMP-dependent protein kinase" []
is_a: IMR:0000251 ! PKG

[Term]
id: IMR:0000677
name: cGMP-dependent protein kinase II
exact_synonym: "type II cGMP-dependent protein kinase" []
is_a: IMR:0000251 ! PKG

[Term]
id: IMR:0000679
name: Plk1
is_a: IMR:0000256 ! Plk

[Term]
id: IMR:0000680
name: Plk3
is_a: IMR:0000256 ! Plk

[Term]
id: IMR:0000681
name: non-receptor serine/threonine kinase
xref_analog: GO:0004702
is_a: IMR:0000223 ! protein serine/threonine kinase

[Term]
id: IMR:0000682
name: non-receptor tyrosine kinase
xref_analog: GO:0004715
xref_analog: GO:0004716
is_a: IMR:0000210 ! protein tyrosine kinase

[Term]
id: IMR:0000683
name: JNK1
exact_synonym: "p54 gamma SAPK" []
exact_synonym: "SAPK-1" []
is_a: IMR:0000225 ! JNK/SAPK

[Term]
id: IMR:0000684
name: JNK2
exact_synonym: "p54 alpha SAPK" []
is_a: IMR:0000225 ! JNK/SAPK

[Term]
id: IMR:0000685
name: JNK3
exact_synonym: "p54 beta SAPK" []
is_a: IMR:0000225 ! JNK/SAPK

[Term]
id: IMR:0000686
name: p38alpha
exact_synonym: "CRK1" []
exact_synonym: "CSBP1" []
exact_synonym: "CSBP2" []
exact_synonym: "MPK2" []
exact_synonym: "Mxi2" []
exact_synonym: "p38 MAPK" []
exact_synonym: "p38/HOG1" []
exact_synonym: "p40" []
exact_synonym: "RK" []
exact_synonym: "RK/p38" []
exact_synonym: "SAPK-2" []
exact_synonym: "SAPK2a" []
is_a: IMR:0000226 ! p38

[Term]
id: IMR:0000687
name: p38beta
exact_synonym: "p38-2" []
exact_synonym: "SAPK2b" []
is_a: IMR:0000226 ! p38

[Term]
id: IMR:0000688
name: p38gamma
exact_synonym: "ERK6" []
exact_synonym: "SAPK-3" []
is_a: IMR:0000226 ! p38

[Term]
id: IMR:0000689
name: p38delta
exact_synonym: "SAPK-4" []
is_a: IMR:0000226 ! p38

[Term]
id: IMR:0000691
name: calcitonin gene-related peptide I
exact_synonym: "CGRP-I" []
is_a: IMR:0100162 ! calcitonin gene-related peptide

[Term]
id: IMR:0000692
name: calcitonin gene-related peptide II
exact_synonym: "CGRP-II" []
is_a: IMR:0100162 ! calcitonin gene-related peptide

[Term]
id: IMR:0000693
name: neurophysin 1
is_a: IMR:0100163 ! neurophysin

[Term]
id: IMR:0000694
name: neurophysin 2
is_a: IMR:0100163 ! neurophysin

[Term]
id: IMR:0000695
name: H-Ras
alt_id: IMR:0011341
exact_synonym: "c-H-ras" []
exact_synonym: "HRAS" []
exact_synonym: "Transforming protein p21/H-Ras-1" []
is_a: IMR:0000290 ! Ras

[Term]
id: IMR:0000696
name: N-Ras
alt_id: IMR:0011343
exact_synonym: "NRAS" []
exact_synonym: "Transforming protein N-Ras" []
is_a: IMR:0000290 ! Ras

[Term]
id: IMR:0000697
name: K-Ras2A
alt_id: IMR:0011342
exact_synonym: "c-K-ras" []
exact_synonym: "K-Ras 2A" []
exact_synonym: "K-Ras4A" []
exact_synonym: "Ki-Ras" []
exact_synonym: "KRAS2" []
exact_synonym: "Transforming protein p21A" []
is_a: IMR:0000291 ! K-Ras

[Term]
id: IMR:0000698
name: K-Ras2B
exact_synonym: "K-Ras4B" []
is_a: IMR:0000291 ! K-Ras

[Term]
id: IMR:0000699
name: Cdc42
is_a: IMR:0000295 ! Rho family

[Term]
id: IMR:0000700
name: p50:RelA
is_a: IMR:0000382 ! NF-kappaB

[Term]
id: IMR:0000701
name: IKK family
exact_synonym: "I-kappaB kinase family" []
xref_analog: GO:0008384
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000702
name: BMPRII
is_a: IMR:0000094 ! TGF-beta receptor type II

[Term]
id: IMR:0000703
name: ALK-2/ActRI
is_a: IMR:0000093 ! TGF-beta receptor type I

[Term]
id: IMR:0000704
name: ALK-3/BMP-RIA
exact_synonym: "BMPRIA" []
is_a: IMR:0001425 ! BMPRI

[Term]
id: IMR:0000705
name: ALK-6/BMP-RIB
exact_synonym: "BMPRIB" []
is_a: IMR:0001425 ! BMPRI

[Term]
id: IMR:0000706
name: ALK-4/ActRIB
is_a: IMR:0000093 ! TGF-beta receptor type I

[Term]
id: IMR:0000707
name: ActRII
is_a: IMR:0000094 ! TGF-beta receptor type II

[Term]
id: IMR:0000708
name: ActRIIB
is_a: IMR:0000094 ! TGF-beta receptor type II

[Term]
id: IMR:0000709
name: ALK-7
is_a: IMR:0000093 ! TGF-beta receptor type I

[Term]
id: IMR:0000710
name: ALK-5/TbetaRI
exact_synonym: "activin receptor-like kinase-5" []
exact_synonym: "ALK-5" []
is_a: IMR:0000093 ! TGF-beta receptor type I

[Term]
id: IMR:0000711
name: ALK-1
is_a: IMR:0000093 ! TGF-beta receptor type I

[Term]
id: IMR:0000712
name: TbetaRII
is_a: IMR:0000094 ! TGF-beta receptor type II

[Term]
id: IMR:0000713
name: AMHR
is_a: IMR:0000094 ! TGF-beta receptor type II

[Term]
id: IMR:0000714
name: PLCbeta1
exact_synonym: "phospholipase C beta 1" []
is_a: IMR:0000286 ! PLCbeta

[Term]
id: IMR:0000715
name: PLCbeta2
exact_synonym: "phospholipase C beta 2" []
is_a: IMR:0000286 ! PLCbeta

[Term]
id: IMR:0000716
name: PLCbeta3
exact_synonym: "phospholipase C beta 3" []
is_a: IMR:0000286 ! PLCbeta

[Term]
id: IMR:0000717
name: PLCbeta4
exact_synonym: "phospholipase C beta 4" []
is_a: IMR:0000286 ! PLCbeta

[Term]
id: IMR:0000718
name: adenylate cyclase type I
exact_synonym: "adenylate cyclase type 1" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000719
name: adenylate cyclase type II
exact_synonym: "adenylate cyclase type 2" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000720
name: adenylate cyclase type III
exact_synonym: "adenylate cyclase type 3" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000721
name: adenylate cyclase type IV
exact_synonym: "adenylate cyclase type 4" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000722
name: adenylate cyclase type V
exact_synonym: "adenylate cyclase type 5" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000723
name: adenylate cyclase type VI
exact_synonym: "adenylate cyclase type 6" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000724
name: adenylate cyclase type VII
exact_synonym: "adenylate cyclase type 7" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000725
name: adenylate cyclase type VIII
exact_synonym: "adenylate cyclase type 8" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000726
name: adenylate cyclase type IX
exact_synonym: "adenylate cyclase type 9" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000727
name: group IB phospholipase A2
is_a: IMR:0000283 ! PLA2

[Term]
id: IMR:0000728
name: PLD1
exact_synonym: "phospholipase D1" []
is_a: IMR:0000287 ! PLD

[Term]
id: IMR:0000729
name: PLD2
exact_synonym: "phospholipase D2" []
is_a: IMR:0000287 ! PLD

[Term]
id: IMR:0000730
name: GPI-PLD1
alt_id: IMR:0000731
exact_synonym: "glycosylphosphatidylinositol phospholipase D1" []
exact_synonym: "phosphatidylinositol-glycan-specific phospholipase D1" []
is_a: IMR:0001997 ! GPI-PLD

[Term]
id: IMR:0000732
name: PLC gamma1
exact_synonym: "phospholipase C gamma 1" []
is_a: IMR:0000285 ! PLC gamma

[Term]
id: IMR:0000733
name: PLC gamma2
exact_synonym: "phospholipase C gamma 2" []
is_a: IMR:0000285 ! PLC gamma

[Term]
id: IMR:0000734
name: COX-1
exact_synonym: "prostaglandin endoperoxide synthase 2" []
is_a: IMR:0000331 ! COX

[Term]
id: IMR:0000735
name: COX-2
exact_synonym: "prostaglandin endoperoxide synthase 2" []
is_a: IMR:0000331 ! COX

[Term]
id: IMR:0000736
name: Grb10
alt_id: IMR:0010277
exact_synonym: "GRB10 adaptor protein" []
exact_synonym: "Growth factor receptor-bound protein 10" []
exact_synonym: "Insulin receptor binding protein GRB-IR" []
is_a: IMR:0100382 ! Grb7/10/14 family

[Term]
id: IMR:0000737
name: Grb14
is_a: IMR:0100382 ! Grb7/10/14 family

[Term]
id: IMR:0000738
name: ShcA
alt_id: IMR:0010596
alt_id: IMR:0011555
is_a: IMR:0000347 ! Shc

[Term]
id: IMR:0000739
name: ShcB
is_a: IMR:0000347 ! Shc

[Term]
id: IMR:0000740
name: ShcC
is_a: IMR:0000347 ! Shc

[Term]
id: IMR:0000741
name: Gads
def: "Gads is a member of the family of SH2 and SH3 domain containing adaptor proteins that is expressed specifically in hematopoietic cells and functions in the coordination of tyrosine kinase mediated signal transduction. Gads is a unique member of the Grb2 adaptor family." [PubMed:11607830]
exact_synonym: "Grb2-related adaptor downstream of Shc" []
is_a: IMR:0000339 ! Grb2 family

[Term]
id: IMR:0000742
name: DD-containing adaptor protein
exact_synonym: "death domain-containing adaptor protein" []
is_a: IMR:0000333 ! adaptor protein

[Term]
id: IMR:0000743
name: adaptor protein
comment: This term was made obsolete. To update annotations, consider the term 'IMR0000333:adaptor protein'.
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0000744
name: anchoring protein
comment: This term was made obsolete. To update annotations, consider the term 'IMR0000333:adaptor protein'.
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0000745
name: Crk family
def: "Alternative splicing of the mammal crk gene yields two translation products designated the 28-kDa Crk-I and the 42-kDa Crk-II protein. The Crk-II protein contains an amino-terminal SH2 domain followed by two SH3 domains. The Crk-I protein does not contain the second SH3 domain. The 36-kDa Crk-L protein is similar to CrkII, but is encoded by a separate gene." [PubMed:10393272]
is_a: IMR:0000334 ! SH2/SH3 adaptor protein

[Term]
id: IMR:0000746
name: intracellular ligand-gated ion channel
xref_analog: GO:0005217
is_a: IMR:0000082 ! ligand-gated ion channel
is_a: IMR:0001013 ! intracellular ligand receptor

[Term]
id: IMR:0000747
name: extracellular ligand-gated ion channel
xref_analog: GO:0005230
is_a: IMR:0000082 ! ligand-gated ion channel
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000748
name: voltage-gated calcium channel
exact_synonym: "voltage-dependent calcium channel" []
xref_analog: GO:0005245
is_a: IMR:0000499 ! calcium channel
is_a: IMR:0100584 ! voltage-gated ion channel

[Term]
id: IMR:0000749
name: L-type Ca2+ channel
def: "L for long-lasting. Wide distribution, well characterized in heart, smooth and skeltal muscle and some neurones. Highly sensitive to the dihydropyridines, phenylalkylamines and the  benzothiazepines. Consists of five subunits, known as alpha1, alpha2, beta, gamma and delta. The delta subunit is linked by disulphide bonds to the alpha2 subunit." [ISBN:0121844536]
exact_synonym: "voltage-dependent L-type calcium channel" []
exact_synonym: "voltage-gated L-type calcium channel" []
is_a: IMR:0000748 ! voltage-gated calcium channel

[Term]
id: IMR:0000750
name: voltage-gated calcium channel alpha-1C subunit
is_a: IMR:0000751 ! L-type Ca2+ channel alpha-1 subunit

[Term]
id: IMR:0000751
name: L-type Ca2+ channel alpha-1 subunit
def: "The alpha-1 subunit contains the pore of the channel and is the main site of action of the L-type-specific Ca2+ channel agonists and antagonists." [ISBN:0121844536]
relationship: part_of IMR:0000749 ! L-type Ca2+ channel

[Term]
id: IMR:0000752
name: voltage-gated calcium channel alpha-1D subunit
is_a: IMR:0000751 ! L-type Ca2+ channel alpha-1 subunit

[Term]
id: IMR:0000753
name: voltage-gated calcium channel alpha-1F subunit
is_a: IMR:0000751 ! L-type Ca2+ channel alpha-1 subunit

[Term]
id: IMR:0000754
name: voltage-gated calcium channel alpha-1S subunit
is_a: IMR:0000751 ! L-type Ca2+ channel alpha-1 subunit

[Term]
id: IMR:0000755
name: voltage-gated calcium channel beta subunit
relationship: part_of IMR:0000749 ! L-type Ca2+ channel
relationship: part_of IMR:0000772 ! N-type Ca2+ channel

[Term]
id: IMR:0000756
name: voltage-gated calcium channel beta-1 subunit
is_a: IMR:0000755 ! voltage-gated calcium channel beta subunit

[Term]
id: IMR:0000757
name: voltage-gated calcium channel beta-2 subunit
is_a: IMR:0000755 ! voltage-gated calcium channel beta subunit

[Term]
id: IMR:0000758
name: voltage-gated calcium channel beta-3 subunit
is_a: IMR:0000755 ! voltage-gated calcium channel beta subunit

[Term]
id: IMR:0000759
name: voltage-gated calcium channel beta-4 subunit
is_a: IMR:0000755 ! voltage-gated calcium channel beta subunit

[Term]
id: IMR:0000760
name: voltage-gated calcium channel alpha-2/delta subunit
relationship: part_of IMR:0000749 ! L-type Ca2+ channel
relationship: part_of IMR:0000772 ! N-type Ca2+ channel

[Term]
id: IMR:0000761
name: voltage-gated calcium channel alpha-1B subunit
relationship: part_of IMR:0000772 ! N-type Ca2+ channel

[Term]
id: IMR:0000762
name: voltage-gated calcium channel gamma subunit
relationship: part_of IMR:0000749 ! L-type Ca2+ channel

[Term]
id: IMR:0000763
name: voltage-gated calcium channel gamma-1 subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000764
name: voltage-gated calcium channel gamma-2 subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000765
name: voltage-gated calcium channel gamma-3 subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000766
name: voltage-gated calcium channel gamma-4 subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000767
name: voltage-gated calcium channel gamma-5 subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000768
name: voltage-gated calcium channel gamma-6 subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000769
name: voltage-gated calcium channel gamma-7 subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000770
name: voltage-gated calcium channel gamma-8 subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000771
name: voltage-gated calcium channel gamma-like subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000772
name: N-type Ca2+ channel
def: "N for neuronal, neither L nor T. Found specifically in neurones. Blocked by omega-conotoxin GVIA (omega-CTx-GVIA). Consists of alpha1, alpha2-delta and beta subunits. " [ISBN:0121844536]
exact_synonym: "voltage-dependent N-type calcium channel" []
exact_synonym: "voltage-gated N-type calcium channel" []
is_a: IMR:0000748 ! voltage-gated calcium channel

[Term]
id: IMR:0000773
name: T-type Ca2+ channel
def: "T for transient. Low voltage activated transient current. Rapid voltage-dependent inactivation. Concentrated in conducting system of heart (sinoatrial node, atrioventricular node), smooth muscle, endocrine cells and some neurones. In the mature mammalian brain, they are prominent in thalamic and hypothalamic neurones." [ISBN:0121844536]
is_a: IMR:0000748 ! voltage-gated calcium channel

[Term]
id: IMR:0000774
name: ryanodine receptor
exact_synonym: "RyR" []
is_a: IMR:0000499 ! calcium channel
is_a: IMR:0000746 ! intracellular ligand-gated ion channel

[Term]
id: IMR:0000775
name: store-operated calcium channel
is_a: IMR:0000499 ! calcium channel

[Term]
id: IMR:0000776
name: P/Q-type Ca2+ channel
is_a: IMR:0000748 ! voltage-gated calcium channel

[Term]
id: IMR:0000777
name: voltage-gated sodium channel
is_a: IMR:0000497 ! sodium channel
is_a: IMR:0100584 ! voltage-gated ion channel

[Term]
id: IMR:0000778
name: voltage-gated calcium channel alpha-1A subunit
relationship: part_of IMR:0000776 ! P/Q-type Ca2+ channel

[Term]
id: IMR:0000779
name: T-type Ca2+ channel alpha-1 subunit
relationship: part_of IMR:0000773 ! T-type Ca2+ channel

[Term]
id: IMR:0000780
name: voltage-gated calcium channel alpha-1G subunit
is_a: IMR:0000779 ! T-type Ca2+ channel alpha-1 subunit

[Term]
id: IMR:0000781
name: voltage-gated calcium channel alpha-1H subunit
is_a: IMR:0000779 ! T-type Ca2+ channel alpha-1 subunit

[Term]
id: IMR:0000782
name: voltage-gated calcium channel alpha-1I subunit
is_a: IMR:0000779 ! T-type Ca2+ channel alpha-1 subunit

[Term]
id: IMR:0000783
name: R-type Ca2+ channel
is_a: IMR:0000748 ! voltage-gated calcium channel

[Term]
id: IMR:0000784
name: voltage-gated calcium channel alpha-1E subunit
relationship: part_of IMR:0000783 ! R-type Ca2+ channel

[Term]
id: IMR:0000785
name: amiloride-sensitive sodium channel
exact_synonym: "ENaC" []
exact_synonym: "epithelial sodium channel" []
is_a: IMR:0000497 ! sodium channel
is_a: IMR:0000746 ! intracellular ligand-gated ion channel

[Term]
id: IMR:0000786
name: voltage-gated sodium channel alpha subunit
relationship: part_of IMR:0000777 ! voltage-gated sodium channel

[Term]
id: IMR:0000787
name: voltage-gated sodium channel beta subunit
relationship: part_of IMR:0000777 ! voltage-gated sodium channel

[Term]
id: IMR:0000788
name: Nav1.1
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000789
name: Nav1.2
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000790
name: Nav1.3
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000791
name: Nav1.4
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000792
name: Nav1.5
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000793
name: Nav1.6
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000794
name: Nav1.7
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000795
name: Nav1.8
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000796
name: Nav1.9
exact_synonym: "NaN" []
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000797
name: Nax
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000798
name: voltage-gated sodium channel beta-1 subunit
is_a: IMR:0000787 ! voltage-gated sodium channel beta subunit

[Term]
id: IMR:0000799
name: voltage-gated sodium channel beta-2 subunit
is_a: IMR:0000787 ! voltage-gated sodium channel beta subunit

[Term]
id: IMR:0000800
name: voltage-gated sodium channel beta-3 subunit
is_a: IMR:0000787 ! voltage-gated sodium channel beta subunit

[Term]
id: IMR:0000801
name: amiloride-sensitive sodium channel alpha subunit
exact_synonym: "ENaC alpha subunit" []
exact_synonym: "epithelial sodium channel alpha subunit" []
relationship: part_of IMR:0000785 ! amiloride-sensitive sodium channel

[Term]
id: IMR:0000802
name: amiloride-sensitive sodium channel beta subunit
exact_synonym: "ENaC beta subunit" []
exact_synonym: "epithelial sodium channel beta subunit" []
relationship: part_of IMR:0000785 ! amiloride-sensitive sodium channel

[Term]
id: IMR:0000803
name: amiloride-sensitive sodium channel gamma subunit
exact_synonym: "ENaC gamma subunit" []
exact_synonym: "epithelial sodium channel gamma subunit" []
relationship: part_of IMR:0000785 ! amiloride-sensitive sodium channel

[Term]
id: IMR:0000804
name: amiloride-sensitive sodium channel delta subunit
exact_synonym: "ENaC delta subunit" []
exact_synonym: "epithelial sodium channel delta subunit" []
relationship: part_of IMR:0000785 ! amiloride-sensitive sodium channel

[Term]
id: IMR:0000805
name: GADD45 alpha
is_a: IMR:0000559 ! GADD45

[Term]
id: IMR:0000806
name: GADD45 beta
exact_synonym: "MyD118" []
is_a: IMR:0000559 ! GADD45

[Term]
id: IMR:0000807
name: GADD45 gamma
exact_synonym: "CR6" []
is_a: IMR:0000559 ! GADD45

[Term]
id: IMR:0000808
name: disabled-1
is_a: IMR:0000558 ! disabled

[Term]
id: IMR:0000809
name: disabled-2
exact_synonym: "DOC-2" []
is_a: IMR:0000558 ! disabled

[Term]
id: IMR:0000810
name: DAB_DROME
exact_synonym: "cDNA C" [FlyBase:FBgn0000414]
exact_synonym: "CG9695" [FlyBase:FBgn0000414]
exact_synonym: "Dab" [UniProt:P98081, FlyBase:FBgn0000414]
exact_synonym: "dab" [FlyBase:FBgn0000414]
exact_synonym: "disabled" [FlyBase:FBgn0000414]
exact_synonym: "Disabled" [FlyBase:FBgn0000414]
exact_synonym: "Protein disabled" [UniProt:P98081]
xref_analog: UniProt:P98081
relationship: sequence_of IMR:0000558 ! disabled

[Term]
id: IMR:0000811
name: CD80
def: "B7.1 (CD80) and B7.2 (CD86) - the two structurally homologous ligands of CD28 - are expressed by professional antigen-presenting cells (APCs), such as dendritic cells (DCs), macrophages and activated B cells, belong to the immunoglobulin superfamily and might exist as dimers and monomers, respectively." [PubMed:14647476]
exact_synonym: "B7.1" []
is_a: IMR:0002950 ! CD80/CD86

[Term]
id: IMR:0000812
name: CD86
def: "B7.1 (CD80) and B7.2 (CD86) - the two structurally homologous ligands of CD28 - are expressed by professional antigen-presenting cells (APCs), such as dendritic cells (DCs), macrophages and activated B cells, belong to the immunoglobulin superfamily and might exist as dimers and monomers, respectively." [PubMed:14647476]
exact_synonym: "B7.2" []
is_a: IMR:0002950 ! CD80/CD86

[Term]
id: IMR:0000813
name: c-FOS
is_a: IMR:0000415 ! FOS

[Term]
id: IMR:0000814
name: FOSB
is_a: IMR:0000415 ! FOS

[Term]
id: IMR:0000815
name: FRA-1
is_a: IMR:0000415 ! FOS

[Term]
id: IMR:0000816
name: FRA-2
is_a: IMR:0000415 ! FOS

[Term]
id: IMR:0000817
name: c-JUN
exact_synonym: "AP-1" []
is_a: IMR:0000416 ! JUN

[Term]
id: IMR:0000818
name: JUNB
is_a: IMR:0000416 ! JUN

[Term]
id: IMR:0000819
name: JUND
is_a: IMR:0000416 ! JUN

[Term]
id: IMR:0000820
name: c-Maf
is_a: IMR:0000411 ! Maf

[Term]
id: IMR:0000821
name: MafF
is_a: IMR:0000411 ! Maf

[Term]
id: IMR:0000822
name: MafG
is_a: IMR:0000411 ! Maf

[Term]
id: IMR:0000823
name: MafK
is_a: IMR:0000411 ! Maf

[Term]
id: IMR:0000824
name: MafB
is_a: IMR:0000411 ! Maf

[Term]
id: IMR:0000825
name: ATF
exact_synonym: "activating transcription factor" []
is_a: IMR:0000369 ! transcriptional regulator
relationship: part_of IMR:0000414 ! AP-1

[Term]
id: IMR:0000826
name: ATF-1
exact_synonym: "activating transcription factor 1" []
is_a: IMR:0000825 ! ATF

[Term]
id: IMR:0000827
name: ATF-2
exact_synonym: "activating transcription factor 2" []
is_a: IMR:0000825 ! ATF

[Term]
id: IMR:0000828
name: ATF-3
exact_synonym: "activating transcription factor 3" []
is_a: IMR:0000825 ! ATF

[Term]
id: IMR:0000829
name: ATF-4
exact_synonym: "activating transcription factor 4" []
is_a: IMR:0000825 ! ATF

[Term]
id: IMR:0000830
name: ATF-5
exact_synonym: "activating transcription factor 5" []
is_a: IMR:0000825 ! ATF

[Term]
id: IMR:0000831
name: ATF-6 alpha
exact_synonym: "activating transcription factor 6 alpha" []
is_a: IMR:0000825 ! ATF

[Term]
id: IMR:0000832
name: ATF-6 beta
exact_synonym: "activating transcription factor 6 beta" []
is_a: IMR:0000825 ! ATF

[Term]
id: IMR:0000833
name: ATF-7
exact_synonym: "activating transcription factor 7" []
exact_synonym: "ATF-a" []
is_a: IMR:0000825 ! ATF

[Term]
id: IMR:0000834
name: C/EBP alpha
exact_synonym: "CCAAT/enhancer binding protein alpha" []
is_a: IMR:0000422 ! C/EBP

[Term]
id: IMR:0000835
name: C/EBP beta
exact_synonym: "CCAAT/enhancer binding protein beta" []
is_a: IMR:0000422 ! C/EBP

[Term]
id: IMR:0000836
name: C/EBP delta
exact_synonym: "CCAAT/enhancer binding protein delta" []
is_a: IMR:0000422 ! C/EBP

[Term]
id: IMR:0000837
name: C/EBP gamma
exact_synonym: "CCAAT/enhancer binding protein gamma" []
is_a: IMR:0000422 ! C/EBP

[Term]
id: IMR:0000838
name: C/EBP epsilon
exact_synonym: "CCAAT/enhancer binding protein epsilon" []
is_a: IMR:0000422 ! C/EBP

[Term]
id: IMR:0000839
name: E2F-1
alt_id: IMR:0010715
exact_synonym: "E2F-1" []
exact_synonym: "E2F1" []
exact_synonym: "PBR3" []
exact_synonym: "PRB-binding protein E2F-1" []
exact_synonym: "RBAP-1" []
exact_synonym: "RBBP-3" []
exact_synonym: "Retinoblastoma binding protein 3" []
exact_synonym: "Retinoblastoma-associated protein 1" []
exact_synonym: "Transcription factor E2F1" []
is_a: IMR:0000848 ! E2F

[Term]
id: IMR:0000840
name: E2F-2
alt_id: IMR:0010717
exact_synonym: "E2F2" []
exact_synonym: "Transcription factor E2F2" []
is_a: IMR:0000848 ! E2F

[Term]
id: IMR:0000841
name: E2F-3
alt_id: IMR:0010232
exact_synonym: "E2F3" []
exact_synonym: "Transcription factor E2F3" []
is_a: IMR:0000848 ! E2F

[Term]
id: IMR:0000842
name: E2F-4
alt_id: IMR:0010720
exact_synonym: "E2F4" []
exact_synonym: "Transcription factor E2F4" []
exact_synonym: "Transcription factor E2F4 (E2F-4)" []
is_a: IMR:0000848 ! E2F

[Term]
id: IMR:0000843
name: E2F-5
alt_id: IMR:0010721
exact_synonym: "E2F5" []
exact_synonym: "Transcription factor E2F5" []
exact_synonym: "Transcription factor E2F5 (E2F-5)" []
is_a: IMR:0000848 ! E2F

[Term]
id: IMR:0000844
name: E2F-6
is_a: IMR:0000848 ! E2F

[Term]
id: IMR:0000845
name: DP-1
alt_id: IMR:0010718
exact_synonym: "DP-1" []
exact_synonym: "DRTF1" []
exact_synonym: "DRTF1- polypeptide-1" []
exact_synonym: "E2F dimerization partner 1" []
exact_synonym: "Transcription factor Dp-1" []
exact_synonym: "Transcription factor DP-1 (E2F dimerization partner 1)(DRTF1-polypeptide-1) (DRTF1)" []
is_a: IMR:0000847 ! DP

[Term]
id: IMR:0000846
name: DP-2
is_a: IMR:0000847 ! DP

[Term]
id: IMR:0000847
name: DP
exact_synonym: "DRTF1 protein" []
xref_analog: IPR:003316
relationship: part_of IMR:0000396 ! DRTF1/E2F

[Term]
id: IMR:0000848
name: E2F
xref_analog: IPR:003316
relationship: part_of IMR:0000396 ! DRTF1/E2F

[Term]
id: IMR:0000849
name: GATA-1
is_a: IMR:0000410 ! GATA

[Term]
id: IMR:0000850
name: GATA-2
is_a: IMR:0000410 ! GATA

[Term]
id: IMR:0000851
name: GATA-3
is_a: IMR:0000410 ! GATA

[Term]
id: IMR:0000852
name: GATA-4
is_a: IMR:0000410 ! GATA

[Term]
id: IMR:0000853
name: GATA-5
is_a: IMR:0000410 ! GATA

[Term]
id: IMR:0000854
name: GATA-6
is_a: IMR:0000410 ! GATA

[Term]
id: IMR:0000855
name: NF-ATc1
is_a: IMR:0000421 ! NF-AT

[Term]
id: IMR:0000856
name: NF-ATc2
is_a: IMR:0000421 ! NF-AT

[Term]
id: IMR:0000857
name: NF-ATc3
is_a: IMR:0000421 ! NF-AT

[Term]
id: IMR:0000858
name: NF-ATc4
is_a: IMR:0000421 ! NF-AT

[Term]
id: IMR:0000859
name: 14-3-3 beta
alt_id: IMR:0010101
exact_synonym: "14-3-3 protein beta/alpha" []
exact_synonym: "KCIP-1" []
exact_synonym: "Protein 1054" []
exact_synonym: "Protein kinase C inhibitor protein-1" []
is_a: IMR:0000456 ! 14-3-3

[Term]
id: IMR:0000860
name: 14-3-3 gamma
is_a: IMR:0000456 ! 14-3-3

[Term]
id: IMR:0000861
name: 14-3-3 epsilon
is_a: IMR:0000456 ! 14-3-3

[Term]
id: IMR:0000862
name: 14-3-3 eta
is_a: IMR:0000456 ! 14-3-3

[Term]
id: IMR:0000863
name: 14-3-3 sigma
is_a: IMR:0000456 ! 14-3-3

[Term]
id: IMR:0000864
name: 14-3-3 tau/theta
is_a: IMR:0000456 ! 14-3-3

[Term]
id: IMR:0000865
name: 14-3-3 zeta
is_a: IMR:0000456 ! 14-3-3

[Term]
id: IMR:0000866
name: A-Myb
is_a: IMR:0000868 ! Myb family

[Term]
id: IMR:0000867
name: B-Myb
is_a: IMR:0000868 ! Myb family

[Term]
id: IMR:0000868
name: Myb family
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000869
name: NF1-A
alt_id: IMR:0010365
exact_synonym: "CCAAT-box binding transcription factor" []
exact_synonym: "CTF" []
exact_synonym: "NF-I/A" []
exact_synonym: "NF1-A" []
exact_synonym: "NFI-A" []
exact_synonym: "Nuclear factor 1 A-type" []
exact_synonym: "Nuclear factor 1/A" []
exact_synonym: "TGGCA-binding protein" []
is_a: IMR:0000409 ! NF1

[Term]
id: IMR:0000870
name: NF1-B
alt_id: IMR:0010366
exact_synonym: "CCAAT-box binding transcription factor" []
exact_synonym: "CTF" []
exact_synonym: "NF-I/B" []
exact_synonym: "NF1-B" []
exact_synonym: "NFI-B" []
exact_synonym: "Nuclear factor 1 B-type" []
exact_synonym: "Nuclear factor 1/B" []
exact_synonym: "TGGCA-binding protein" []
is_a: IMR:0000409 ! NF1

[Term]
id: IMR:0000871
name: NF1-C
alt_id: IMR:0010367
exact_synonym: "CCAAT-box binding transcription factor" []
exact_synonym: "CTF" []
exact_synonym: "NF-I/C" []
exact_synonym: "NF1-C" []
exact_synonym: "NFI-C" []
exact_synonym: "Nuclear factor 1 C-type" []
exact_synonym: "Nuclear factor 1/C" []
exact_synonym: "TGGCA-binding protein" []
is_a: IMR:0000409 ! NF1

[Term]
id: IMR:0000872
name: NF1-X
alt_id: IMR:0010368
exact_synonym: "CCAAT-box binding transcription factor" []
exact_synonym: "CTF" []
exact_synonym: "NF-I/X" []
exact_synonym: "NF1-X" []
exact_synonym: "NFI-X" []
exact_synonym: "Nuclear factor 1 X-type" []
exact_synonym: "Nuclear factor 1/X" []
exact_synonym: "TGGCA-binding protein" []
is_a: IMR:0000409 ! NF1

[Term]
id: IMR:0000873
name: p52
exact_synonym: "NF-kappaB2" []
exact_synonym: "NFKB2" []
exact_synonym: "p100" []
is_a: IMR:0000382 ! NF-kappaB

[Term]
id: IMR:0000874
name: lipid second messenger
comment: This term was made obsolete. To update annotations, consider the term 'IMR0100022:second messenger'.
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0000875
name: sphingolipid products second messenger
comment: This term was made obsolete. To update annotations, consider the term 'IMR0100022:second messenger'.
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0000877
name: fat-soluble vitamin
xref_analog: CHEBI:24020
is_a: IMR:0001656 ! vitamin

[Term]
id: IMR:0000879
name: general transcription factor
exact_synonym: "basal transcription factor" []
exact_synonym: "basic transcription factor" []
is_a: IMR:0000368 ! transcription factor

[Term]
id: IMR:0000880
name: RNA polymerase I
exact_synonym: "pol I" []
is_a: IMR:0010028 ! RNA polymerase

[Term]
id: IMR:0000881
name: RNA polymerase II
exact_synonym: "pol II" []
is_a: IMR:0010028 ! RNA polymerase

[Term]
id: IMR:0000882
name: RNA polymerase III
exact_synonym: "pol III" []
is_a: IMR:0010028 ! RNA polymerase

[Term]
id: IMR:0000883
name: TFIIA
is_a: IMR:0000888 ! pol II general transcription factor

[Term]
id: IMR:0000884
name: TFIID
is_a: IMR:0000888 ! pol II general transcription factor

[Term]
id: IMR:0000885
name: TFIIE
is_a: IMR:0000888 ! pol II general transcription factor

[Term]
id: IMR:0000886
name: TFIIF
is_a: IMR:0000888 ! pol II general transcription factor

[Term]
id: IMR:0000887
name: TFIIH
is_a: IMR:0000888 ! pol II general transcription factor

[Term]
id: IMR:0000888
name: pol II general transcription factor
exact_synonym: "general RNA polymerase II transcription factor" []
exact_synonym: "TFII" []
exact_synonym: "transcription factor for RNA polymerase II" []
is_a: IMR:0000879 ! general transcription factor

[Term]
id: IMR:0000889
name: transcription elongation factor
exact_synonym: "transcriptional elongation factor" []
xref_analog: GO:0003711
is_a: IMR:0000368 ! transcription factor

[Term]
id: IMR:0000890
name: IRAK-1
exact_synonym: "IL-1 receptor-associated kinase 1" []
exact_synonym: "Interleukin-1 receptor-associated kinase 1" []
is_a: IMR:0100488 ! IRAK

[Term]
id: IMR:0000891
name: IRAK-2
exact_synonym: "IL-1 receptor-associated kinase 2" []
exact_synonym: "Interleukin-1 receptor-associated kinase-2" []
is_a: IMR:0100488 ! IRAK

[Term]
id: IMR:0000892
name: IRAK-4
exact_synonym: "IL-1 receptor-associated kinase 4" []
exact_synonym: "Interleukin-1 receptor-associated kinase-4" []
is_a: IMR:0100488 ! IRAK

[Term]
id: IMR:0000893
name: TAB2
exact_synonym: "TAK1-binding protein 2" []
is_a: IMR:0002665 ! TAB

[Term]
id: IMR:0000894
name: Tollip
exact_synonym: "Toll-interacting protein" []
is_a: IMR:0000333 ! adaptor protein

[Term]
id: IMR:0000895
name: MCM2-7
is_a: IMR:0100678 ! DNA replication factor

[Term]
id: IMR:0000896
name: 40S ribosomal protein
is_a: IMR:0100710 ! ribosomal protein

[Term]
id: IMR:0000897
name: 60S ribosomal protein
is_a: IMR:0100710 ! ribosomal protein

[Term]
id: IMR:0000898
name: 4E-BP
exact_synonym: "eukaryotic translation initiation factor 4E binding protein" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000899
name: 4E-BP2
exact_synonym: "eIF4E-binding protein 2" []
exact_synonym: "Eukaryotic translation initiation factor 4E binding protein 2" []
exact_synonym: "PHAS-II" []
exact_synonym: "Phosphorylated heat- and acid-stable protein regulated by insulin 2" []
is_a: IMR:0000898 ! 4E-BP

[Term]
id: IMR:0000900
name: 4E-BP3
exact_synonym: "eIF4E-binding protein 3" []
exact_synonym: "Eukaryotic translation initiation factor 4E binding protein 3" []
is_a: IMR:0000898 ! 4E-BP

[Term]
id: IMR:0000901
name: translation initiation factor
xref_analog: GO:0003743
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000902
name: eIF2
def: "heterotrimer of alpha, beta, gamma subunits. binds the initiator Met-tRNA to the 40S ribosomal subunit. GTP binding to eIF2 is necessary for formation of a stable eIF2:GTP:Met-tRNA ternary complex (TC). Following TC binding to the ribosome triggers GTP hydrolysis by eIF2." [PubMed:12581660, PubMed:14635255]
exact_synonym: "eukaryotic initiation factor 2" []
is_a: IMR:0000914 ! GTP-binding protein
is_a: IMR:0010016 ! eIF

[Term]
id: IMR:0000903
name: eIF2B
def: "heteropentamer of alpha, beta, gamma, delta, epsilon subunits. guanine nucleotide exchange factor (GEF) activity of eIF2B is necessary to recycle eIF2:GTP to eIF2:GTP." [PubMed:12581660, PubMed:14635255]
exact_synonym: "eukaryotic initiation factor 2B" []
is_a: IMR:0000433 ! GEF
is_a: IMR:0010016 ! eIF

[Term]
id: IMR:0000904
name: eIF3
def: "consists of a core of five non-identical subunits (eIF3a, eIF3b, eIF3c, eIF3i and eIF3g in yeast) and up to six additional subunits in mammals (eIF3d, eIF3e, eIF3f, eIF3h, eIFj and eIF3k). binding to and stabilization of ternary complex, binding to the 40S ribosome, facilitating the binding of mRNA to the 40S ribosome, and promoting dissociation of 40S and 60S ribosomal subunits" [PubMed:11426420, PubMed:14635255]
exact_synonym: "eukaryotic initiation factor 3" []
is_a: IMR:0010016 ! eIF

[Term]
id: IMR:0000905
name: ATP-dependent RNA helicase
xref_analog: GO:0004004
is_a: IMR:0010034 ! helicase

[Term]
id: IMR:0000906
name: eIF4A
def: "eIF4A is a DEADbox helicase that can unwind RNA secondary structure in the cap-proximal region of the mRNA." [PubMed:14635255]
exact_synonym: "eukaryotic initiation factor 4A" []
is_a: IMR:0000905 ! ATP-dependent RNA helicase
is_a: IMR:0000912 ! eIF4F subunit
relationship: part_of IMR:0000909 ! eIF4F

[Term]
id: IMR:0000907
name: eIF4A (yeast)
comment: This term was made obsolete. To update annotations, consider the term 'IMR0701931:IF4A_YEAST' and/or 'IMR0701932:IF4A_SCHPO'.
exact_synonym: "eIF-4A" []
exact_synonym: "Eukaryotic initiation factor 4A" []
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0000908
name: eIF1
is_a: IMR:0010016 ! eIF

[Term]
id: IMR:0000909
name: eIF4F
def: "eIF4F is a heterotrimeric complex that binds to the cap structure at the 50 end of the mRNA. It is composed of eIF4G and the cap-binding protein eIF4E and the ATPdependent RNA helicase eIF4A." [PubMed:14635255]
is_a: IMR:0010016 ! eIF

[Term]
id: IMR:0000910
name: eIF4G
def: "Mammalian cells contain two isoforms of eIF4G (I&II). eIF4G is a subunit of the heterotrimeric eIF4F complex that binds to the cap structure at the 50 end of the mRNA." [PubMed:14635255]
exact_synonym: "eukaryotic translation initiation factor 4G" []
is_a: IMR:0000912 ! eIF4F subunit
relationship: part_of IMR:0000909 ! eIF4F

[Term]
id: IMR:0000911
name: eIF4GII
exact_synonym: "eIF-4-gamma 3" []
exact_synonym: "eIF-4-gamma II" []
exact_synonym: "eIF-4G 3" []
exact_synonym: "eIF4G 3" []
exact_synonym: "Eukaryotic translation initiation factor 4 gamma 3" []
is_a: IMR:0000910 ! eIF4G

[Term]
id: IMR:0000912
name: eIF4F subunit
is_a: IMR:0010016 ! eIF

[Term]
id: IMR:0000913
name: eIF2 subunit
is_a: IMR:0010016 ! eIF

[Term]
id: IMR:0000914
name: GTP-binding protein
exact_synonym: "G-protein" []
xref_analog: GO:0005525
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000915
name: eIF2B subunit
is_a: IMR:0010016 ! eIF

[Term]
id: IMR:0000916
name: eIF3 subunit
is_a: IMR:0010016 ! eIF

[Term]
id: IMR:0000917
name: pol II transcription elongation factor
xref_analog: GO:0016944
is_a: IMR:0000889 ! transcription elongation factor

[Term]
id: IMR:0000918
name: ATPase
xref_analog: GO:0016887
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0000919
name: 11S regulatory complex
def: "composed of three related proteins, termed PA28alpha, PA28beta and PA28gamma. PA28alpha and PA28beta assemble into a heterohexameric complex with alternating a and b subunits, i.e. PA28(ab)3. In contrast, PA28gamma appears to form a homopolymeric complex, presumably PA28(g)6." [PubMed:9797452]
exact_synonym: "PA28 activator" []
is_a: IMR:0001014 ! proteasome activator subunit

[Term]
id: IMR:0000920
name: transporter
def: "Binds the specific solute to be transported and undergo a series of conformational changes to transfer the bound solute across the bilayer." [ISBN:0815340729]
exact_synonym: "carrier" []
exact_synonym: "permease" []
is_a: IMR:0001049 ! membrane transport protein

[Term]
id: IMR:0000921
name: glucose transporter
xref_analog: GO:0005355
xref_analog: IPR:000803
is_a: IMR:0000920 ! transporter

[Term]
id: IMR:0000922
name: F-type ATPase
exact_synonym: "ATP synthase" []
exact_synonym: "F(0)F(1)-ATPase" []
exact_synonym: "F(o)F(1)-ATPase" []
exact_synonym: "F-ATPase" []
exact_synonym: "F-type ATPase" []
exact_synonym: "F1F0-ATP synthase" []
exact_synonym: "F1Fo-ATP synthase" []
exact_synonym: "F1Fo-ATPase" []
exact_synonym: "mitochondrial ATP synthase" []
exact_synonym: "proton-transporting ATP synthase complex" []
xref_analog: GO:0045255
xref_analog: GO:0045259
xref_analog: GO:0046933
xref_analog: GO:0046961
is_a: IMR:0001054 ! proton-translocating ATPase
is_a: IMR:0001156 ! ATP synthase

[Term]
id: IMR:0000925
name: splicing factor
exact_synonym: "pre-mRNA splicing factor" []
xref_analog: GO:0008248
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000926
name: nucleoside transporter
def: "In mammalian cells, there are two major nucleoside transporter gene families: the equilibrative nucleoside transporters (ENTs) and the concentrative nucleoside transporters (CNTs)." [PubMed:12440702, PubMed:14965251]
xref_analog: GO:0005337
is_a: IMR:0000920 ! transporter

[Term]
id: IMR:0000927
name: concentrative nucleoside transporter
def: "concentrative nucleoside transporters cotranslocate nucleosides and sodium unidirectionally against the nucleoside concentration gradients and play a vital role in certain tissues." [PubMed:12440702, PubMed:14965251]
exact_synonym: "CNT" []
is_a: IMR:0000926 ! nucleoside transporter

[Term]
id: IMR:0000928
name: equilibrative nucleoside transporter
def: "translocate nucleosides and nucleobases bidirectionally down their concentration gradients and are important in the uptake of anticancer and antiviral nucleoside drugs." [PubMed:12440702, PubMed:14965251]
exact_synonym: "ENT" []
is_a: IMR:0000926 ! nucleoside transporter

[Term]
id: IMR:0000929
name: amino acid transporter
xref_analog: GO:0015171
is_a: IMR:0000920 ! transporter

[Term]
id: IMR:0000931
name: U2AF
exact_synonym: "U2 auxiliary factor" []
is_a: IMR:0000925 ! splicing factor

[Term]
id: IMR:0000932
name: spliceosome
def: "The splicing reaction is carried out by the spliceosome, which consists of five small nuclear ribonucleoprotein complexes U1, U2, U4, U5 and U6 snRNPs and a large number of non-snRNP proteins." [PubMed:11343900]
xref_analog: GO:0005681
is_a: IMR:0000925 ! splicing factor

[Term]
id: IMR:0000933
name: small nuclear ribonucleoprotein
exact_synonym: "snRNP" []
is_a: IMR:0000925 ! splicing factor

[Term]
id: IMR:0000934
name: U1 small nuclear ribonucleoprotein
exact_synonym: "U1 snRNP" []
xref_analog: GO:0005685
is_a: IMR:0000933 ! small nuclear ribonucleoprotein
relationship: part_of IMR:0000932 ! spliceosome

[Term]
id: IMR:0000935
name: U2 small nuclear ribonucleoprotein
exact_synonym: "U2 snRNP" []
xref_analog: GO:0005686
is_a: IMR:0000933 ! small nuclear ribonucleoprotein
relationship: part_of IMR:0000932 ! spliceosome

[Term]
id: IMR:0000937
name: U5 small nuclear ribonucleoprotein
exact_synonym: "U5 snRNP" []
xref_analog: GO:0005682
is_a: IMR:0000933 ! small nuclear ribonucleoprotein
relationship: part_of IMR:0000932 ! spliceosome

[Term]
id: IMR:0000938
name: U4 small nuclear ribonucleoprotein
exact_synonym: "U4 snRNP" []
xref_analog: GO:0005687
is_a: IMR:0000933 ! small nuclear ribonucleoprotein
relationship: part_of IMR:0000932 ! spliceosome

[Term]
id: IMR:0000939
name: U6 small nuclear ribonucleoprotein
exact_synonym: "U6 snRNP" []
xref_analog: GO:0005688
is_a: IMR:0000933 ! small nuclear ribonucleoprotein
relationship: part_of IMR:0000932 ! spliceosome

[Term]
id: IMR:0000940
name: SR protein
exact_synonym: "serine/arginine-rich protein" []
is_a: IMR:0000925 ! splicing factor

[Term]
id: IMR:0000942
name: phosphatidate phosphatase
exact_synonym: "phosphatidic acid phosphatase" []
exact_synonym: "phosphatidic acid phosphohydrolase" []
xref_analog: EC:3.1.3.4
is_a: IMR:0000517 ! phosphatase

[Term]
id: IMR:0000943
name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
is_a: IMR:0000944 ! fructose-2,6-bisphosphate 2-phosphatase

[Term]
id: IMR:0000944
name: fructose-2,6-bisphosphate 2-phosphatase
xref_analog: EC:3.1.3.46
xref_analog: GO:0004331
is_a: IMR:0000517 ! phosphatase

[Term]
id: IMR:0000945
name: fructose-1,6-bisphosphatase (family)
xref_analog: EC:3.1.3.11
is_a: IMR:0000517 ! phosphatase

[Term]
id: IMR:0000946
name: lysophosphatidic acid acyltransferase
def: "Lysophosphatidic acid (LPA) acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase (1-AGPAT) (EC 2.3.1.51), catalyzes the conversion of LPA to phosphatidic acid (PA)." [PubMed:11487472]
exact_synonym: "1-acyl sn-glycerol-3-phosphate acyltransferase" []
exact_synonym: "1-AGPAT" []
exact_synonym: "LPAAT" []
xref_analog: EC:2.3.1.51
xref_analog: GO:0003841
is_a: IMR:0010050 ! transferase

[Term]
id: IMR:0000947
name: chemical
is_a: IMR:0000001 ! MoleculeRole

[Term]
id: IMR:0000949
name: protein
is_a: IMR:0000001 ! MoleculeRole

[Term]
id: IMR:0000950
name: cellular structure protein
xref_analog: GO:0005198
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000951
name: aminotransferase
exact_synonym: "transaminase" []
xref_analog: EC:2.6.1.-
is_a: IMR:0010050 ! transferase

[Term]
id: IMR:0000952
name: oxidoreductase
xref_analog: EC:1.-.-.-
xref_analog: GO:0016491
is_a: IMR:0000207 ! enzyme

[Term]
id: IMR:0000953
name: methyltransferase
xref_analog: EC:2.1.1.-
xref_analog: GO:0008168
is_a: IMR:0010050 ! transferase

[Term]
id: IMR:0000954
name: nucleotidyltransferase
xref_analog: EC:2.7.7.-
xref_analog: GO:0016779
is_a: IMR:0010050 ! transferase

[Term]
id: IMR:0000955
name: acyltransferase
xref_analog: EC:2.3.-.-
xref_analog: GO:0008415
is_a: IMR:0010050 ! transferase

[Term]
id: IMR:0000956
name: phosphofructokinase
exact_synonym: "PFK" []
xref_analog: GO:0008443
is_a: IMR:0000512 ! kinase

[Term]
id: IMR:0000959
name: ubiquitin related enzyme
is_a: IMR:0000207 ! enzyme

[Term]
id: IMR:0000960
name: GTPase
xref_analog: EC:3.6.5.-
xref_analog: GO:0003924
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0000961
name: cyclase
xref_analog: GO:0009975
is_a: IMR:0010054 ! lyase

[Term]
id: IMR:0000962
name: LRP3
exact_synonym: "LDL receptor-related protein 3" []
exact_synonym: "low density lipoprotein receptor-related protein 3" []
is_a: IMR:0100798 ! LRP family

[Term]
id: IMR:0000963
name: LRP4
exact_synonym: "LDL receptor-related protein 4" []
exact_synonym: "low density lipoprotein receptor-related protein 4" []
is_a: IMR:0100798 ! LRP family

[Term]
id: IMR:0000964
name: LRP5
exact_synonym: "LDL receptor-related protein 5" []
exact_synonym: "low density lipoprotein receptor-related protein 5" []
exact_synonym: "LRP7" []
is_a: IMR:0002954 ! LRP5/LRP6
is_a: IMR:0100798 ! LRP family

[Term]
id: IMR:0000965
name: chemical ligand
is_a: IMR:0000947 ! chemical

[Term]
id: IMR:0000966
name: chemical hormone
is_a: IMR:0000965 ! chemical ligand

[Term]
id: IMR:0000967
name: chemical neurotransmitter
is_a: IMR:0000965 ! chemical ligand

[Term]
id: IMR:0000970
name: LRP6
exact_synonym: "LDL receptor-related protein 6" []
exact_synonym: "low density lipoprotein receptor-related protein 6" []
is_a: IMR:0002954 ! LRP5/LRP6
is_a: IMR:0100798 ! LRP family

[Term]
id: IMR:0000971
name: Rbx1
exact_synonym: "Ring-box 1" []
exact_synonym: "ROC1" []
relationship: part_of IMR:0100470 ! SCF ubiquitin ligase complex

[Term]
id: IMR:0000973
name: LRP8
exact_synonym: "LDL receptor-related protein 8" []
exact_synonym: "low density lipoprotein receptor-related protein 8" []
is_a: IMR:0100798 ! LRP family

[Term]
id: IMR:0000974
name: LDL receptor family
exact_synonym: "LDLR family" []
exact_synonym: "low density lipoprotein receptor family" []
exact_synonym: "low-density lipoprotein receptor family" []
xref_analog: GO:0005041
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000975
name: LRP1B
exact_synonym: "LDL receptor-related protein 1B" []
is_a: IMR:0100798 ! LRP family

[Term]
id: IMR:0000976
name: LRP10
exact_synonym: "LDL receptor-related protein 10" []
is_a: IMR:0100798 ! LRP family

[Term]
id: IMR:0000977
name: LRP11
exact_synonym: "LDL receptor-related protein 11" []
is_a: IMR:0100798 ! LRP family

[Term]
id: IMR:0000978
name: LRP12
exact_synonym: "LDL receptor-related protein 12" []
is_a: IMR:0100798 ! LRP family

[Term]
id: IMR:0000979
name: LDL receptor
exact_synonym: "low density lipoprotein receptor" []
exact_synonym: "low-density lipoprotein receptor" []
is_a: IMR:0000974 ! LDL receptor family

[Term]
id: IMR:0000980
name: Q95V09_DROME
exact_synonym: "arr" [UniProt:Q95V09, FlyBase:FBgn0000119]
exact_synonym: "Arrow" [UniProt:Q95V09]
exact_synonym: "arrow" [FlyBase:FBgn0000119]
exact_synonym: "BEST:CK00539" [FlyBase:FBgn0000119]
exact_synonym: "CG5912" [FlyBase:FBgn0000119]
exact_synonym: "CK00539" [FlyBase:FBgn0000119]
exact_synonym: "CT15575" [FlyBase:FBgn0000119]
exact_synonym: "l(2)k08131" [FlyBase:FBgn0000119]
exact_synonym: "LDL-related protein 6" [FlyBase:FBgn0000119]
exact_synonym: "LDLR-like" [FlyBase:FBgn0000119]
exact_synonym: "LRP" [FlyBase:FBgn0000119]
exact_synonym: "LRP5/6" [FlyBase:FBgn0000119]
exact_synonym: "LRP6" [FlyBase:FBgn0000119]
xref_analog: UniProt:Q95V09
relationship: sequence_of IMR:0002951 ! Arrow/LRP5/LRP6
relationship: sequence_of IMR:0100798 ! LRP family

[Term]
id: IMR:0000981
name: Porcupine family
is_a: IMR:0000955 ! acyltransferase

[Term]
id: IMR:0000982
name: MOM2_CAEEL
exact_synonym: "mom-2" [UniProt:Q10459]
exact_synonym: "Protein mom-2" [UniProt:Q10459]
xref_analog: UniProt:Q10459
relationship: sequence_of IMR:0000003 ! Wnt

[Term]
id: IMR:0000983
name: SFRP
exact_synonym: "secreted frizzled-related protein" []
is_a: IMR:0001160 ! negative regulator of Wnt signaling pathway

[Term]
id: IMR:0000984
name: FRZB
exact_synonym: "Fritz" []
exact_synonym: "Frizzled-related protein" []
exact_synonym: "Frzb-1" []
exact_synonym: "SFRP3" []
is_a: IMR:0000983 ! SFRP

[Term]
id: IMR:0000985
name: SFRP1
is_a: IMR:0000983 ! SFRP

[Term]
id: IMR:0000986
name: SFRP2
is_a: IMR:0000983 ! SFRP

[Term]
id: IMR:0000987
name: SFRP4
is_a: IMR:0000983 ! SFRP

[Term]
id: IMR:0000988
name: SFRP5
is_a: IMR:0000983 ! SFRP

[Term]
id: IMR:0000989
name: WIF
exact_synonym: "Wnt inhibitory factor" []
is_a: IMR:0001160 ! negative regulator of Wnt signaling pathway

[Term]
id: IMR:0000990
name: WIF-1
exact_synonym: "Wnt inhibitory factor 1" []
is_a: IMR:0000989 ! WIF

[Term]
id: IMR:0000991
name: DKK
exact_synonym: "Dickkopf" []
is_a: IMR:0001160 ! negative regulator of Wnt signaling pathway

[Term]
id: IMR:0000992
name: DKK-1
exact_synonym: "Dickkopf-1" []
is_a: IMR:0000991 ! DKK

[Term]
id: IMR:0000993
name: DKK-2
exact_synonym: "Dickkopf-2" []
is_a: IMR:0000991 ! DKK

[Term]
id: IMR:0000994
name: DKK-3
exact_synonym: "Dickkopf-3" []
is_a: IMR:0000991 ! DKK

[Term]
id: IMR:0000995
name: DKK-4
exact_synonym: "Dickkopf-4" []
is_a: IMR:0000991 ! DKK

[Term]
id: IMR:0000996
name: Kremen
is_a: IMR:0001012 ! extracellular ligand receptor
is_a: IMR:0001160 ! negative regulator of Wnt signaling pathway

[Term]
id: IMR:0000997
name: Kremen 1
is_a: IMR:0000996 ! Kremen

[Term]
id: IMR:0000998
name: Kremen 2
is_a: IMR:0000996 ! Kremen

[Term]
id: IMR:0000999
name: acyl-CoA dehydrogenase
def: "There are nine known members in the acyl-CoA dehydrogenase (ACAD) family. Five members of the ACAD family are involved in fatty acid beta-oxidation; these are short, medium, long and very long chain acyl-CoA dehydrogenase (SCAD, MCAD, LCAD and VLCAD1, resepctively), and ACAD-9 (VLCAD2). The four other members are involved in amino acid oxidation pathways; they are iso(3)valeryl-CoA dehydrogenase (i3VD) for leucine, iso(2)valeryl-CoA dehydrogenase (i2VD, also known as short/branched chain acyl-CoA dehydrogenase or 2-methylbutyryl-CoA dehydrogenase) for isoleucine, isobutyryl-CoA dehydrogenase (iBD) for valine, and glutaryl-CoA dehydrogenase (GD) for lysine and tryptophan." [PubMed:14728675]
xref_analog: GO:0003995
is_a: IMR:0010047 ! dehydrogenase

[Term]
id: IMR:0001000
name: aldehyde dehydrogenase
xref_analog: GO:0004028
is_a: IMR:0010047 ! dehydrogenase

[Term]
id: IMR:0001001
name: alcohol dehydrogenase
xref_analog: EC:1.1.1.1
xref_analog: GO:0004022
is_a: IMR:0010047 ! dehydrogenase

[Term]
id: IMR:0001002
name: pyruvate dehydrogenase complex
def: "The mammalian pyruvate dehydrogenase complex is built around a 60-subunit inner core of tightly but noncovalently associated dihydrolipoamide acetyltransferase subunits (E2). Pyruvate dehydrogenase (E1) is a heterotetrameric alpha2beta2 structure that binds noncovalently to an E1-binding domain on E2. Dihydrolipoamide dehydrogenase (E3) binds to the complex by way of an E3-binding protein (E3BP). Twelve E3-binding proteins anchor 12 E3 homodimers to each pyruvate dehydrogenase complex. If the regulatory proteins associated with the complex are not included, each pyruvate dehydrogenase complex is composed of 216 subunits (60 E2, 60 E1alpha, 60 E1beta, 12 E3BP, and 24 E3) that sum up to about 9.5 MD." [PubMed:12123719]
exact_synonym: "PDC" []
xref_analog: GO:0045254
is_a: IMR:0010047 ! dehydrogenase

[Term]
id: IMR:0001003
name: 2-oxoglutarate dehydrogenase complex
exact_synonym: "alpha-ketoglutarate dehydrogenase complex" []
xref_analog: GO:0045240
is_a: IMR:0010047 ! dehydrogenase

[Term]
id: IMR:0001004
name: IMP dehydrogenase
exact_synonym: "inosine monophosphate dehydrogenase" []
xref_analog: EC:1.1.1.205
xref_analog: GO:0003938
is_a: IMR:0010047 ! dehydrogenase

[Term]
id: IMR:0001005
name: isocitrate dehydrogenase (NAD+)
exact_synonym: "NAD+-dependent isocitrate dehydrogenase" []
xref_analog: EC:1.1.1.41
xref_analog: GO:0004449
is_a: IMR:0010047 ! dehydrogenase

[Term]
id: IMR:0001006
name: L-lactate dehydrogenase
xref_analog: EC:1.1.1.27
xref_analog: GO:0004459
is_a: IMR:0010047 ! dehydrogenase

[Term]
id: IMR:0001007
name: branched-chain alpha-keto acid dehydrogenase complex
is_a: IMR:0010047 ! dehydrogenase

[Term]
id: IMR:0001008
name: complex II
def: "Eukaryotic mitochondrial complex II (succinate dehydrogenase) and E. coli succinate:quinone oxidoreductase (SQR) are composed of two hydrophilic subunits, a flavoprotein (SDHA) and iron-sulfur protein (SDHB) subunit, and two hydrophobic membrane anchor subunits, SDHC and SDHD." [PubMed:11803021, PubMed:12560540, PubMed:12560550]
exact_synonym: "CII" []
exact_synonym: "SQR" []
exact_synonym: "succinate dehydrogenase" []
exact_synonym: "succinate-ubiquinone oxidoreductase" []
exact_synonym: "succinate:quinone oxidoreductase" []
xref_analog: GO:0045273
xref_analog: GO:0045281
is_a: IMR:0010047 ! dehydrogenase

[Term]
id: IMR:0001009
name: dioxygenase
is_a: IMR:0010041 ! oxygenase

[Term]
id: IMR:0001010
name: monooxygenase
is_a: IMR:0010041 ! oxygenase

[Term]
id: IMR:0001011
name: ribonucleoside-diphosphate reductase
xref_analog: EC:1.17.4.1
xref_analog: GO:0004748
is_a: IMR:0010045 ! reductase

[Term]
id: IMR:0001012
name: extracellular ligand receptor
is_a: IMR:0000054 ! receptor

[Term]
id: IMR:0001013
name: intracellular ligand receptor
is_a: IMR:0000054 ! receptor

[Term]
id: IMR:0001014
name: proteasome activator subunit
exact_synonym: "proteasome regulatory particle" []
is_a: IMR:0000429 ! enzyme regulator

[Term]
id: IMR:0001015
name: 5'-nucleotidase
xref_analog: EC:3.1.3.5
xref_analog: GO:0008253
is_a: IMR:0010038 ! nucleotidase

[Term]
id: IMR:0001016
name: cAMP-specific 3',5'-cyclic phosphodiesterase 4A
is_a: IMR:0100700 ! cAMP phosphodiesterase

[Term]
id: IMR:0001017
name: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
is_a: IMR:0100700 ! cAMP phosphodiesterase

[Term]
id: IMR:0001018
name: cAMP-specific 3',5'-cyclic phosphodiesterase 4C
is_a: IMR:0100700 ! cAMP phosphodiesterase

[Term]
id: IMR:0001019
name: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
is_a: IMR:0100700 ! cAMP phosphodiesterase

[Term]
id: IMR:0001020
name: High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
is_a: IMR:0100700 ! cAMP phosphodiesterase

[Term]
id: IMR:0001021
name: cAMP-specific 3',5'-cyclic phosphodiesterase 7B
is_a: IMR:0100700 ! cAMP phosphodiesterase

[Term]
id: IMR:0001022
name: cGMP-specific 3',5'-cyclic phosphodiesterase
exact_synonym: "CGB-PDE" []
exact_synonym: "cGMP-binding cGMP-specific phosphodiesterase" []
is_a: IMR:0100002 ! cGMP phosphodiesterase

[Term]
id: IMR:0001023
name: High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
is_a: IMR:0100002 ! cGMP phosphodiesterase

[Term]
id: IMR:0001024
name: Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase gamma-subunit
exact_synonym: "GMP-PDE gamma" []
is_a: IMR:0100002 ! cGMP phosphodiesterase

[Term]
id: IMR:0001025
name: Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit
is_a: IMR:0100002 ! cGMP phosphodiesterase

[Term]
id: IMR:0001026
name: Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit
exact_synonym: "GMP-PDE beta" []
is_a: IMR:0100002 ! cGMP phosphodiesterase

[Term]
id: IMR:0001027
name: Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit
is_a: IMR:0100002 ! cGMP phosphodiesterase

[Term]
id: IMR:0001028
name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase delta-subunit
exact_synonym: "GMP-PDE delta" []
is_a: IMR:0100002 ! cGMP phosphodiesterase

[Term]
id: IMR:0001029
name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase gamma-subunit
exact_synonym: "GMP-PDE gamma" []
is_a: IMR:0100002 ! cGMP phosphodiesterase

[Term]
id: IMR:0001030
name: group III secretory phospholipase A2
is_a: IMR:0000283 ! PLA2

[Term]
id: IMR:0001031
name: group V phospholipase A2
is_a: IMR:0000283 ! PLA2

[Term]
id: IMR:0001032
name: group VI phospholipase A2
is_a: IMR:0000283 ! PLA2

[Term]
id: IMR:0001033
name: group IIA phospholipase A2
is_a: IMR:0000283 ! PLA2

[Term]
id: IMR:0001034
name: group IID secretory phospholipase A2
is_a: IMR:0000283 ! PLA2

[Term]
id: IMR:0001035
name: group IIE secretory phospholipase A2
is_a: IMR:0000283 ! PLA2

[Term]
id: IMR:0001036
name: group IIF secretory phospholipase A2
is_a: IMR:0000283 ! PLA2

[Term]
id: IMR:0001037
name: group X secretory phospholipase A2
is_a: IMR:0000283 ! PLA2

[Term]
id: IMR:0001038
name: group XIIA secretory phospholipase A2
is_a: IMR:0000283 ! PLA2

[Term]
id: IMR:0001039
name: group XIIB secretory phospholipase A2-like protein
is_a: IMR:0000283 ! PLA2

[Term]
id: IMR:0001040
name: group IVA phospholipase A2
is_a: IMR:0000283 ! PLA2

[Term]
id: IMR:0001041
name: group IVC phospholipase A2
is_a: IMR:0000283 ! PLA2

[Term]
id: IMR:0001042
name: group IIC secretory phospholipase A2
is_a: IMR:0000283 ! PLA2

[Term]
id: IMR:0001043
name: thiolester hydrolases
xref_analog: EC:3.1.2.-
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0001044
name: ubiquitin thiolesterase
exact_synonym: "ubiquitin carboxy-terminal esterase" []
exact_synonym: "ubiquitin carboxy-terminal hydrolase" []
xref_analog: EC:3.1.2.15
is_a: IMR:0001043 ! thiolester hydrolases

[Term]
id: IMR:0001045
name: CD45
exact_synonym: "CD45 antigen" []
exact_synonym: "common leukocyte antigen" []
exact_synonym: "leukocyte common antigen" []
exact_synonym: "Ly-5 antigen" []
is_a: IMR:0000062 ! receptor protein-tyrosine phosphatase

[Term]
id: IMR:0001046
name: F(1)
exact_synonym: "proton-transporting ATP synthase complex, catalytic core F(1)" []
xref_analog: GO:0045261
relationship: part_of IMR:0000922 ! F-type ATPase

[Term]
id: IMR:0001047
name: F(0)
exact_synonym: "proton-transporting ATP synthase complex, coupling factor F(o)" []
xref_analog: GO:0045263
relationship: part_of IMR:0000922 ! F-type ATPase

[Term]
id: IMR:0001048
name: V-type ATPase
exact_synonym: "V-ATPase" []
exact_synonym: "vacuolar H(+)-ATPase" []
exact_synonym: "vacuolar proton ATPase" []
exact_synonym: "vacuolar proton pump" []
xref_analog: GO:0016471
xref_analog: GO:0046961
is_a: IMR:0001054 ! proton-translocating ATPase

[Term]
id: IMR:0001049
name: membrane transport protein
def: "Transfer solutes (e.g ions, sugars, amino acids, and nucleotides) across the lipid bilayer. Transporters (also called carriers, or permeases) and channels are the two major classes of membrane transport proteins." [ISBN:0815340729]
xref_analog: GO:0005215
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0001050
name: ion transporter
xref_analog: GO:0015075
is_a: IMR:0000920 ! transporter

[Term]
id: IMR:0001051
name: proton pump
is_a: IMR:0001050 ! ion transporter

[Term]
id: IMR:0001052
name: H+,K+-ATPase
exact_synonym: "gastric H+,K+ ATPase" []
exact_synonym: "proton pump" []
exact_synonym: "proton/potassium ATPase" []
xref_analog: EC:3.6.3.10
xref_analog: GO:0005889
xref_analog: GO:0008900
is_a: IMR:0001053 ! P-type ATPase

[Term]
id: IMR:0001053
name: P-type ATPase
xref_analog: EC:3.6.3.6
xref_analog: GO:0008553
is_a: IMR:0001054 ! proton-translocating ATPase

[Term]
id: IMR:0001054
name: proton-translocating ATPase
exact_synonym: "H+ pump ATPase" []
exact_synonym: "H+-ATPase" []
exact_synonym: "proton ATPase" []
exact_synonym: "proton pump ATPase" []
is_a: IMR:0000918 ! ATPase
is_a: IMR:0001051 ! proton pump

[Term]
id: IMR:0001055
name: H+,K+-ATPase alpha subunit
relationship: part_of IMR:0001052 ! H+,K+-ATPase

[Term]
id: IMR:0001056
name: H+,K+-ATPase beta subunit
relationship: part_of IMR:0001052 ! H+,K+-ATPase

[Term]
id: IMR:0001057
name: V-ATPase d subunit
relationship: part_of IMR:0001058 ! V(0)

[Term]
id: IMR:0001058
name: V(0)
exact_synonym: "V-type ATPase V0 complex" []
relationship: part_of IMR:0001048 ! V-type ATPase

[Term]
id: IMR:0001059
name: V(1)
exact_synonym: "V-type ATPase V1 complex" []
relationship: part_of IMR:0001048 ! V-type ATPase

[Term]
id: IMR:0001060
name: V-ATPase a subunit
relationship: part_of IMR:0001058 ! V(0)

[Term]
id: IMR:0001061
name: V-ATPase c subunit (family)
relationship: part_of IMR:0001058 ! V(0)

[Term]
id: IMR:0001062
name: V-ATPase A subunit
relationship: part_of IMR:0001059 ! V(1)

[Term]
id: IMR:0001063
name: V-ATPase B subunit
relationship: part_of IMR:0001059 ! V(1)

[Term]
id: IMR:0001064
name: V-ATPase C subunit
relationship: part_of IMR:0001059 ! V(1)

[Term]
id: IMR:0001065
name: V-ATPase D subunit
relationship: part_of IMR:0001059 ! V(1)

[Term]
id: IMR:0001066
name: V-ATPase E subunit
relationship: part_of IMR:0001059 ! V(1)

[Term]
id: IMR:0001067
name: V-ATPase F subunit
relationship: part_of IMR:0001059 ! V(1)

[Term]
id: IMR:0001068
name: V-ATPase G subunit
relationship: part_of IMR:0001059 ! V(1)

[Term]
id: IMR:0001069
name: V-ATPase H subunit
relationship: part_of IMR:0001059 ! V(1)

[Term]
id: IMR:0001070
name: V-ATPase A subunit 1
exact_synonym: "Vacuolar ATP synthase catalytic subunit A, ubiquitous isoform" []
is_a: IMR:0001062 ! V-ATPase A subunit

[Term]
id: IMR:0001071
name: V-ATPase A subunit 2
exact_synonym: "Vacuolar ATP synthase catalytic subunit A, osteoclast isoform" []
is_a: IMR:0001062 ! V-ATPase A subunit

[Term]
id: IMR:0001072
name: V-ATPase B subunit 1
exact_synonym: "Vacuolar ATP synthase subunit B, kidney isoform" []
is_a: IMR:0001063 ! V-ATPase B subunit

[Term]
id: IMR:0001073
name: V-ATPase B subunit 2
is_a: IMR:0001063 ! V-ATPase B subunit

[Term]
id: IMR:0001074
name: V-ATPase G subunit 1
is_a: IMR:0001068 ! V-ATPase G subunit

[Term]
id: IMR:0001075
name: V-ATPase G subunit 2
is_a: IMR:0001068 ! V-ATPase G subunit

[Term]
id: IMR:0001076
name: V-ATPase G subunit 3
is_a: IMR:0001068 ! V-ATPase G subunit

[Term]
id: IMR:0001077
name: V-ATPase a subunit 1
is_a: IMR:0001060 ! V-ATPase a subunit

[Term]
id: IMR:0001078
name: V-ATPase a subunit 2
is_a: IMR:0001060 ! V-ATPase a subunit

[Term]
id: IMR:0001079
name: V-ATPase a subunit 3
is_a: IMR:0001060 ! V-ATPase a subunit

[Term]
id: IMR:0001080
name: V-ATPase a subunit 4
is_a: IMR:0001060 ! V-ATPase a subunit

[Term]
id: IMR:0001081
name: V-ATPase c subunit
is_a: IMR:0001061 ! V-ATPase c subunit (family)

[Term]
id: IMR:0001082
name: V-ATPase c' subunit
is_a: IMR:0001061 ! V-ATPase c subunit (family)

[Term]
id: IMR:0001083
name: V-ATPase c'' subunit
is_a: IMR:0001061 ! V-ATPase c subunit (family)

[Term]
id: IMR:0001084
name: importin alpha1
exact_synonym: "importin alpha S1" []
exact_synonym: "importin alpha5" []
exact_synonym: "karyopherin alpha1" []
exact_synonym: "KPNA1" []
exact_synonym: "NPI-1" []
is_a: IMR:0100202 ! importin alpha

[Term]
id: IMR:0001085
name: importin alpha2
exact_synonym: "importin alpha P1" []
exact_synonym: "importin alpha1" []
exact_synonym: "karyopherin alpha2" []
exact_synonym: "KPNA2" []
is_a: IMR:0100202 ! importin alpha

[Term]
id: IMR:0001086
name: importin alpha3
exact_synonym: "importin alpha Q2" []
exact_synonym: "importin alpha4" []
exact_synonym: "karyopherin alpha3" []
exact_synonym: "KPNA3" []
is_a: IMR:0100202 ! importin alpha

[Term]
id: IMR:0001087
name: importin alpha4
exact_synonym: "importin alpha Q1" []
exact_synonym: "importin alpha3" []
exact_synonym: "karyopherin alpha4" []
exact_synonym: "KPNA4" []
exact_synonym: "Qip1" []
is_a: IMR:0100202 ! importin alpha

[Term]
id: IMR:0001088
name: importin alpha6
exact_synonym: "karyopherin alpha5" []
exact_synonym: "KPNA5" []
is_a: IMR:0100202 ! importin alpha

[Term]
id: IMR:0001089
name: importin alpha7
exact_synonym: "importin alpha S2" []
exact_synonym: "karyopherin alpha6" []
exact_synonym: "KPNA6" []
is_a: IMR:0100202 ! importin alpha

[Term]
id: IMR:0001090
name: CRM1
exact_synonym: "exportin 1" []
is_a: IMR:0100015 ! exportin

[Term]
id: IMR:0001091
name: importin/exportin
def: "Members of importin beta family (importins/exportins, karyopherins) have been classified as importins or exportins on the basis of the direction they carry their cargo." [PubMed:11423015, PubMed:11729264, PubMed:12600309, PubMed:15450977]
exact_synonym: "inportin beta family" []
exact_synonym: "inportin beta-like family" []
exact_synonym: "inportin beta-like protein" []
exact_synonym: "inportin beta-like receptor" []
exact_synonym: "Kap" []
exact_synonym: "karyopherin" []
exact_synonym: "karyopherin beta family" []
is_a: IMR:0000653 ! nucleocytoplasmic transport protein

[Term]
id: IMR:0001092
name: FLI1
is_a: IMR:0000397 ! ets

[Term]
id: IMR:0001093
name: ERM
exact_synonym: "ETV5" []
is_a: IMR:0000397 ! ets

[Term]
id: IMR:0001094
name: Elk-1
is_a: IMR:0000397 ! ets

[Term]
id: IMR:0001095
name: Sap-1
exact_synonym: "Elk-4" []
is_a: IMR:0000397 ! ets

[Term]
id: IMR:0001096
name: transportin 1
exact_synonym: "importin beta2" []
exact_synonym: "karyopherin beta2" []
is_a: IMR:0100010 ! importin

[Term]
id: IMR:0001097
name: transportin SR
is_a: IMR:0100010 ! importin

[Term]
id: IMR:0001098
name: exportin 4
is_a: IMR:0100015 ! exportin

[Term]
id: IMR:0001099
name: exportin 7
exact_synonym: "RanBP16" []
is_a: IMR:0100015 ! exportin

[Term]
id: IMR:0001100
name: exportin-t
is_a: IMR:0100015 ! exportin

[Term]
id: IMR:0001101
name: importin 5
exact_synonym: "karyopherin beta3" []
exact_synonym: "RanBP5" []
is_a: IMR:0100010 ! importin

[Term]
id: IMR:0001102
name: importin 7
exact_synonym: "RanBP7" []
is_a: IMR:0100010 ! importin

[Term]
id: IMR:0001103
name: importin 11
is_a: IMR:0100010 ! importin

[Term]
id: IMR:0001104
name: Net
exact_synonym: "Elk-3" []
exact_synonym: "Sap-2" []
is_a: IMR:0000397 ! ets

[Term]
id: IMR:0001105
name: importin 13
is_a: IMR:0100010 ! importin
is_a: IMR:0100015 ! exportin

[Term]
id: IMR:0001106
name: PU.1
is_a: IMR:0000397 ! ets

[Term]
id: IMR:0001107
name: IQGAP1
is_a: IMR:0000443 ! Ras GAP

[Term]
id: IMR:0001108
name: transportin 2
exact_synonym: "karyopherin beta2b" []
is_a: IMR:0100010 ! importin

[Term]
id: IMR:0001109
name: RanBP17
is_a: IMR:0001091 ! importin/exportin

[Term]
id: IMR:0001110
name: RanBP6
is_a: IMR:0001091 ! importin/exportin

[Term]
id: IMR:0001111
name: importin 8
exact_synonym: "RanBP8" []
is_a: IMR:0100010 ! importin

[Term]
id: IMR:0001112
name: importin 4
is_a: IMR:0100010 ! importin

[Term]
id: IMR:0001113
name: importin 9
is_a: IMR:0100010 ! importin

[Term]
id: IMR:0001114
name: exportin 5
is_a: IMR:0100015 ! exportin

[Term]
id: IMR:0001115
name: IQGAP2
is_a: IMR:0000443 ! Ras GAP

[Term]
id: IMR:0001116
name: RASAL1
is_a: IMR:0000443 ! Ras GAP

[Term]
id: IMR:0001117
name: RASA4
is_a: IMR:0000443 ! Ras GAP

[Term]
id: IMR:0001118
name: short chain collagen
xref_analog: GO:0005598
is_a: IMR:0000541 ! collagen

[Term]
id: IMR:0001119
name: alpha 2(VIII) collagen
is_a: IMR:0001123 ! type VIII collagen

[Term]
id: IMR:0001120
name: alpha 1(VIII) collagen
is_a: IMR:0001123 ! type VIII collagen

[Term]
id: IMR:0001121
name: alpha 1(X) collagen
is_a: IMR:0001122 ! type X collagen

[Term]
id: IMR:0001122
name: type X collagen
xref_analog: GO:0005599
is_a: IMR:0001118 ! short chain collagen

[Term]
id: IMR:0001123
name: type VIII collagen
xref_analog: GO:0005591
is_a: IMR:0001118 ! short chain collagen

[Term]
id: IMR:0001124
name: basement membrane collagen
is_a: IMR:0000541 ! collagen

[Term]
id: IMR:0001125
name: heparan sulfate proteoglycan
exact_synonym: "HSPG" []
is_a: IMR:0000552 ! proteoglycan

[Term]
id: IMR:0001126
name: chondroitin sulfate proteoglycan
exact_synonym: "chondroitin sulfate proteoglycan" []
is_a: IMR:0000552 ! proteoglycan

[Term]
id: IMR:0001127
name: chondroitin/dermatan sulfate proteoglycan
exact_synonym: "chondroitin/dermatan sulfate proteoglycan" []
is_a: IMR:0000552 ! proteoglycan

[Term]
id: IMR:0001128
name: keratan sulfate proteoglycan
is_a: IMR:0000552 ! proteoglycan

[Term]
id: IMR:0001129
name: lumican
is_a: IMR:0001128 ! keratan sulfate proteoglycan

[Term]
id: IMR:0001130
name: neurocan
is_a: IMR:0001126 ! chondroitin sulfate proteoglycan

[Term]
id: IMR:0001131
name: perlecan
exact_synonym: "basement membrane heparan sulfate proteoglycan" []
is_a: IMR:0001125 ! heparan sulfate proteoglycan

[Term]
id: IMR:0001132
name: versican
exact_synonym: "PG-M" []
is_a: IMR:0001126 ! chondroitin sulfate proteoglycan

[Term]
id: IMR:0001133
name: aggrecan
is_a: IMR:0001126 ! chondroitin sulfate proteoglycan

[Term]
id: IMR:0001134
name: agrin
is_a: IMR:0001125 ! heparan sulfate proteoglycan

[Term]
id: IMR:0001135
name: bamacan
alt_id: IMR:0100658
exact_synonym: "Bamacan" []
exact_synonym: "Basement membrane-associated chondroitin proteoglycan" []
exact_synonym: "Chondroitin sulfate proteoglycan 6" []
exact_synonym: "Chromosome segregation protein SmcD" []
exact_synonym: "Chromosome-associated polypeptide" []
exact_synonym: "hCAP" []
exact_synonym: "Mad member-interacting protein 1" []
exact_synonym: "Smc3" []
exact_synonym: "Structural maintenance of chromosome 3" []
is_a: IMR:0001126 ! chondroitin sulfate proteoglycan
is_a: IMR:0100651 ! cohesin subunit

[Term]
id: IMR:0001136
name: brevican
is_a: IMR:0001126 ! chondroitin sulfate proteoglycan

[Term]
id: IMR:0001137
name: decorin
is_a: IMR:0001127 ! chondroitin/dermatan sulfate proteoglycan

[Term]
id: IMR:0001138
name: keratocan
is_a: IMR:0001128 ! keratan sulfate proteoglycan

[Term]
id: IMR:0001139
name: glypican
exact_synonym: "GPI-anchored membrane heparan sulfate proteoglycan" []
is_a: IMR:0001125 ! heparan sulfate proteoglycan

[Term]
id: IMR:0001140
name: glypican-1
is_a: IMR:0001139 ! glypican

[Term]
id: IMR:0001141
name: cerebroglycan
exact_synonym: "HSPG-M13" []
is_a: IMR:0001139 ! glypican

[Term]
id: IMR:0001142
name: K-glypican
is_a: IMR:0001139 ! glypican

[Term]
id: IMR:0001143
name: biglycan
is_a: IMR:0001127 ! chondroitin/dermatan sulfate proteoglycan

[Term]
id: IMR:0001144
name: NG2
is_a: IMR:0001126 ! chondroitin sulfate proteoglycan

[Term]
id: IMR:0001145
name: PKC alpha
is_a: IMR:0100486 ! cPKC

[Term]
id: IMR:0001146
name: PKC beta
is_a: IMR:0100486 ! cPKC

[Term]
id: IMR:0001147
name: PKC gamma
is_a: IMR:0100486 ! cPKC

[Term]
id: IMR:0001148
name: PKC delta
is_a: IMR:0000246 ! nPKC

[Term]
id: IMR:0001149
name: PKC epsilon
is_a: IMR:0000246 ! nPKC

[Term]
id: IMR:0001150
name: PKC eta
exact_synonym: "PKC-L" []
is_a: IMR:0000246 ! nPKC

[Term]
id: IMR:0001151
name: PKC zeta
is_a: IMR:0000247 ! aPKC

[Term]
id: IMR:0001152
name: PKC lambda/iota
is_a: IMR:0000247 ! aPKC

[Term]
id: IMR:0001154
name: Ryk
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0001155
name: RYK1_DROME
exact_synonym: "CG10758" [FlyBase:FBgn0015380]
exact_synonym: "CG17348" [FlyBase:FBgn0015380]
exact_synonym: "derailed" [FlyBase:FBgn0015380]
exact_synonym: "drl" [UniProt:Q27324, FlyBase:FBgn0015380]
exact_synonym: "DRL" [FlyBase:FBgn0015380]
exact_synonym: "EC 2.7.10.1" [UniProt:Q27324]
exact_synonym: "lin" [FlyBase:FBgn0015380]
exact_synonym: "linotte" [FlyBase:FBgn0015380]
exact_synonym: "lio" [UniProt:Q27324, FlyBase:FBgn0015380]
exact_synonym: "lio/drl" [FlyBase:FBgn0015380]
exact_synonym: "lionette" [FlyBase:FBgn0015380]
exact_synonym: "Protein derailed" [UniProt:Q27324]
exact_synonym: "Tyrosine-protein kinase Drl" [UniProt:Q27324]
xref_analog: UniProt:Q27324
relationship: sequence_of IMR:0001154 ! Ryk

[Term]
id: IMR:0001156
name: ATP synthase
is_a: IMR:0000207 ! enzyme

[Term]
id: IMR:0001157
name: MESD_DROME
exact_synonym: "boca" [UniProt:Q8T9B6, FlyBase:FBgn0004132]
exact_synonym: "CG1364" [FlyBase:FBgn0004132]
exact_synonym: "CG30498" [FlyBase:FBgn0004132]
exact_synonym: "l(2)43Ea" [FlyBase:FBgn0004132]
exact_synonym: "LDLR chaperone boca" [UniProt:Q8T9B6]
exact_synonym: "lethal(2)43Ea" [FlyBase:FBgn0004132]
xref_analog: UniProt:Q8T9B6
relationship: sequence_of IMR:0001177 ! boca/mesd

[Term]
id: IMR:0001158
name: Norrin
exact_synonym: "Norrie disease gene" []
is_a: IMR:0000002 ! ligand

[Term]
id: IMR:0001159
name: chibby
is_a: IMR:0001160 ! negative regulator of Wnt signaling pathway

[Term]
id: IMR:0001160
name: negative regulator of Wnt signaling pathway
exact_synonym: "inhibitor  of Wnt signaling pathway" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0001161
name: ICAT
exact_synonym: "Inhibitor of beta-catenin and TCF" []
is_a: IMR:0001160 ! negative regulator of Wnt signaling pathway

[Term]
id: IMR:0001162
name: Wise
is_a: IMR:0001160 ! negative regulator of Wnt signaling pathway

[Term]
id: IMR:0001163
name: NLK
comment: This term was made obsolete. To update annotations, consider the term 'IMR0001164:NLK/Nemo/Lit-1'.
exact_synonym: "Nemo-like kinase" []
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0001164
name: NLK/Nemo/Lit-1
exact_synonym: "Lit-1" []
exact_synonym: "Nemo" []
exact_synonym: "Nemo-like kinase" []
exact_synonym: "NLK" []
is_a: IMR:0000681 ! non-receptor serine/threonine kinase
is_a: IMR:0001160 ! negative regulator of Wnt signaling pathway

[Term]
id: IMR:0001165
name: Lit-1
def: "Lit-1 downregulates the activity of POP-1, a TCF/LEF-related protein in C. elegans." [PubMed:10380924]
comment: This term was made obsolete. To update annotations, consider the term 'IMR0001164:NLK/Nemo/Lit-1'.
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0001166
name: histone deacetylase
exact_synonym: "HDAC" []
xref_analog: GO:0004407
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0001167
name: histone deacetylase 1
exact_synonym: "HDAC1" []
is_a: IMR:0001166 ! histone deacetylase

[Term]
id: IMR:0001168
name: histone deacetylase 2
exact_synonym: "HDAC2" []
is_a: IMR:0001166 ! histone deacetylase

[Term]
id: IMR:0001169
name: histone deacetylase 3
exact_synonym: "HDAC3" []
is_a: IMR:0001166 ! histone deacetylase

[Term]
id: IMR:0001170
name: histone deacetylase 4
exact_synonym: "HDAC4" []
is_a: IMR:0001166 ! histone deacetylase

[Term]
id: IMR:0001171
name: histone deacetylase 5
exact_synonym: "HDAC5" []
is_a: IMR:0001166 ! histone deacetylase

[Term]
id: IMR:0001172
name: histone deacetylase 6
exact_synonym: "HDAC6" []
is_a: IMR:0001166 ! histone deacetylase

[Term]
id: IMR:0001173
name: histone deacetylase 7a
exact_synonym: "HDAC7a" []
is_a: IMR:0001166 ! histone deacetylase

[Term]
id: IMR:0001174
name: histone deacetylase 8
exact_synonym: "HDAC8" []
is_a: IMR:0001166 ! histone deacetylase

[Term]
id: IMR:0001175
name: histone deacetylase 9
exact_synonym: "HDAC7b" []
exact_synonym: "HDAC9" []
exact_synonym: "histone deacetylase 7b" []
is_a: IMR:0001166 ! histone deacetylase

[Term]
id: IMR:0001176
name: histone acetyltransferase
exact_synonym: "HAT" []
exact_synonym: "histone acetylase" []
xref_analog: EC:2.3.1.48
xref_analog: GO:0004402
is_a: IMR:0000955 ! acyltransferase

[Term]
id: IMR:0001177
name: boca/mesd
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0001178
name: Legless
exact_synonym: "Bcl-9" []
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0001179
name: Pygopus
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0001180
name: Pygopus1
is_a: IMR:0001179 ! Pygopus

[Term]
id: IMR:0001181
name: Pygopus2
is_a: IMR:0001179 ! Pygopus

[Term]
id: IMR:0001182
name: PYGO_DROME
exact_synonym: "anon-WO02077023.1" [FlyBase:FBgn0043900]
exact_synonym: "BEST:LD21971" [FlyBase:FBgn0043900]
exact_synonym: "CG11518" [FlyBase:FBgn0043900]
exact_synonym: "gam" [UniProt:Q9V9W8, FlyBase:FBgn0043900]
exact_synonym: "gammy legs" [FlyBase:FBgn0043900]
exact_synonym: "pNB5.2" [FlyBase:FBgn0043900]
exact_synonym: "Protein gammy legs" [UniProt:Q9V9W8]
exact_synonym: "Protein pygopus" [UniProt:Q9V9W8]
exact_synonym: "pygo" [UniProt:Q9V9W8, FlyBase:FBgn0043900]
exact_synonym: "Pygo" [FlyBase:FBgn0043900]
exact_synonym: "pygopus" [FlyBase:FBgn0043900]
xref_analog: UniProt:Q9V9W8
relationship: sequence_of IMR:0001179 ! Pygopus

[Term]
id: IMR:0001183
name: PANG1_DROME
exact_synonym: "CG17964" [FlyBase:FBgn0085432]
exact_synonym: "cTCF" [FlyBase:FBgn0085432]
exact_synonym: "dTCF" [UniProt:P91943, FlyBase:FBgn0085432]
exact_synonym: "DTCF" [FlyBase:FBgn0085432]
exact_synonym: "dTcf" [FlyBase:FBgn0085432]
exact_synonym: "DTcf" [FlyBase:FBgn0085432]
exact_synonym: "IA5" [FlyBase:FBgn0085432]
exact_synonym: "l(4)102ABb" [FlyBase:FBgn0085432]
exact_synonym: "l(4)13" [FlyBase:FBgn0085432]
exact_synonym: "LEF-1" [FlyBase:FBgn0085432]
exact_synonym: "LEF/TCF" [FlyBase:FBgn0085432]
exact_synonym: "LEF/TCF-1" [FlyBase:FBgn0085432]
exact_synonym: "lef1" [FlyBase:FBgn0085432]
exact_synonym: "lethal 13" [FlyBase:FBgn0085432]
exact_synonym: "pan" [UniProt:P91943, FlyBase:FBgn0085432]
exact_synonym: "Pan" [FlyBase:FBgn0085432]
exact_synonym: "pangolin" [FlyBase:FBgn0085432]
exact_synonym: "Protein pangolin, isoforms A/H/I" [UniProt:P91943]
exact_synonym: "TCF" [UniProt:P91943, FlyBase:FBgn0085432]
exact_synonym: "Tcf" [FlyBase:FBgn0085432]
exact_synonym: "Tcf-1" [FlyBase:FBgn0085432]
exact_synonym: "TCF/LEF" [FlyBase:FBgn0085432]
exact_synonym: "Tcf/LEF" [FlyBase:FBgn0085432]
exact_synonym: "TCF/LEF1" [FlyBase:FBgn0085432]
xref_analog: UniProt:P91943
relationship: sequence_of IMR:0000418 ! TCF/LEF-1 family

[Term]
id: IMR:0001184
name: MOM-4
comment: This term was made obsolete. To update annotations, consider the term 'IMR0702264:Q9XTC6_CAEEL'.
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0001185
name: TAK1/MOM-4
comment: This term was made obsolete. To update annotations, consider the term 'IMR0000232:TAK1'.
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0001186
name: PAR-5
comment: This term was made obsolete. To update annotations, consider the term 'IMR0702265:14331_CAEEL'.
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0001187
name: PORCN_DROME
exact_synonym: "15175" [FlyBase:FBgn0004957]
exact_synonym: "CG6205" [FlyBase:FBgn0004957]
exact_synonym: "dmPorc" [FlyBase:FBgn0004957]
exact_synonym: "EC 2.3.1.-" [UniProt:Q9VWV9]
exact_synonym: "l(1)17Ac" [FlyBase:FBgn0004957]
exact_synonym: "poc" [FlyBase:FBgn0004957]
exact_synonym: "por" [UniProt:Q9VWV9, FlyBase:FBgn0004957]
exact_synonym: "porc" [UniProt:Q9VWV9, FlyBase:FBgn0004957]
exact_synonym: "Porc" [FlyBase:FBgn0004957]
exact_synonym: "porcupine" [FlyBase:FBgn0004957]
exact_synonym: "Protein-cysteine N-palmitoyltransferase porcupine" [UniProt:Q9VWV9]
xref_analog: UniProt:Q9VWV9
relationship: sequence_of IMR:0000981 ! Porcupine family

[Term]
id: IMR:0001188
name: PORCN_CAEEL
exact_synonym: "EC 2.3.1.-" [UniProt:Q22329]
exact_synonym: "mom-1" [UniProt:Q22329]
exact_synonym: "More of ms protein 1" [UniProt:Q22329]
exact_synonym: "Porc" [UniProt:Q22329]
exact_synonym: "Probable protein-cysteine N-palmitoyltransferase porcupine" [UniProt:Q22329]
xref_analog: UniProt:Q22329
relationship: sequence_of IMR:0000981 ! Porcupine family

[Term]
id: IMR:0001189
name: beta-catenin
comment: This term was made obsolete. To update annotations, consider the term 'IMR0000177:beta-catenin'.
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0001190
name: ARM_DROME
exact_synonym: "arm" [UniProt:P18824, FlyBase:FBgn0000117]
exact_synonym: "Arm" [FlyBase:FBgn0000117]
exact_synonym: "ARM" [FlyBase:FBgn0000117]
exact_synonym: "Armadillo" [FlyBase:FBgn0000117]
exact_synonym: "armadillo" [FlyBase:FBgn0000117]
exact_synonym: "Armadillo segment polarity protein" [UniProt:P18824]
exact_synonym: "b-catenin" [FlyBase:FBgn0000117]
exact_synonym: "beta-cat" [FlyBase:FBgn0000117]
exact_synonym: "beta-Catenin" [FlyBase:FBgn0000117]
exact_synonym: "beta-catenin" [FlyBase:FBgn0000117]
exact_synonym: "Beta-catenin" [FlyBase:FBgn0000117]
exact_synonym: "catenin" [FlyBase:FBgn0000117]
exact_synonym: "CG11579" [FlyBase:FBgn0000117]
exact_synonym: "EG:86E4.6" [FlyBase:FBgn0000117]
exact_synonym: "l(1)2Bv" [FlyBase:FBgn0000117]
exact_synonym: "l(1)arm" [FlyBase:FBgn0000117]
exact_synonym: "l(1)G0192" [FlyBase:FBgn0000117]
exact_synonym: "l(1)G0234" [FlyBase:FBgn0000117]
exact_synonym: "l(1)G0410" [FlyBase:FBgn0000117]
exact_synonym: "t12687 ALR Dm" [FlyBase:FBgn0000117]
xref_analog: UniProt:P18824
relationship: sequence_of IMR:0000177 ! beta-catenin

[Term]
id: IMR:0001191
name: WRM1_CAEEL
exact_synonym: "Armadillo repeat-containing protein wrm-1" [UniProt:Q10953]
exact_synonym: "Worm armadillo protein 1" [UniProt:Q10953]
exact_synonym: "wrm-1" [UniProt:Q10953]
xref_analog: UniProt:Q10953
relationship: sequence_of IMR:0000177 ! beta-catenin

[Term]
id: IMR:0001192
name: O16147_CAEEL
exact_synonym: "mom-5" [UniProt:O16147]
exact_synonym: "Mom-5 protein" [UniProt:O16147]
exact_synonym: "Protein T23D8.1, confirmed by transcript evidence" [UniProt:O16147]
xref_analog: UniProt:O16147
relationship: sequence_of IMR:0000055 ! Frizzled

[Term]
id: IMR:0001193
name: POP1_CAEEL
exact_synonym: "pop-1" [UniProt:Q10666]
exact_synonym: "Posterior pharynx defect protein 1" [UniProt:Q10666]
exact_synonym: "Protein pop-1" [UniProt:Q10666]
xref_analog: UniProt:Q10666
relationship: sequence_of IMR:0000418 ! TCF/LEF-1 family

[Term]
id: IMR:0001194
name: P91667_DROME
exact_synonym: "Adenomatous polyposis coli" [UniProt:P91667]
exact_synonym: "adenomatous polyposis coli" [FlyBase:FBgn0015589]
exact_synonym: "Apc" [UniProt:P91667, FlyBase:FBgn0015589]
exact_synonym: "apc" [FlyBase:FBgn0015589]
exact_synonym: "APC" [FlyBase:FBgn0015589]
exact_synonym: "APC-like" [FlyBase:FBgn0015589]
exact_synonym: "Apc1" [FlyBase:FBgn0015589]
exact_synonym: "APC1" [FlyBase:FBgn0015589]
exact_synonym: "apc1" [FlyBase:FBgn0015589]
exact_synonym: "CG1451" [FlyBase:FBgn0015589]
exact_synonym: "D-APC" [UniProt:P91667, FlyBase:FBgn0015589]
exact_synonym: "d-APC" [FlyBase:FBgn0015589]
exact_synonym: "D-APC1" [FlyBase:FBgn0015589]
exact_synonym: "dApc" [FlyBase:FBgn0015589]
exact_synonym: "dAPC" [FlyBase:FBgn0015589]
exact_synonym: "DAPC" [FlyBase:FBgn0015589]
exact_synonym: "dAPC1" [FlyBase:FBgn0015589]
xref_analog: UniProt:P91667
relationship: sequence_of IMR:0000205 ! APC

[Term]
id: IMR:0001195
name: APC
comment: This term was made obsolete. To update annotations, consider the term 'IMR0000205:APC'.
exact_synonym: "Adenomatous Polyposis Coli Protein" []
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0001197
name: APR1_CAEEL
alt_id: IMR:0001196
exact_synonym: "Adenomatous polyposis coli protein-related protein 1" [UniProt:Q21227]
exact_synonym: "APC-related protein 1" [UniProt:Q21227]
exact_synonym: "apr-1" [UniProt:Q21227]
xref_analog: UniProt:Q21227
relationship: sequence_of IMR:0000205 ! APC

[Term]
id: IMR:0001198
name: DALY_DROME
exact_synonym: "anon-EST:Liang-1.63" [FlyBase:FBgn0011577]
exact_synonym: "CG4974" [FlyBase:FBgn0011577]
exact_synonym: "clone 1.63" [FlyBase:FBgn0011577]
exact_synonym: "CT15952" [FlyBase:FBgn0011577]
exact_synonym: "dally" [FlyBase:FBgn0011577, UniProt:Q24114]
exact_synonym: "Dally" [FlyBase:FBgn0011577]
exact_synonym: "Dally protein" [UniProt:Q24114]
exact_synonym: "division abnormally delayed" [FlyBase:FBgn0011577]
exact_synonym: "Division abnormally delayed protein" [UniProt:Q24114]
exact_synonym: "gem" [FlyBase:FBgn0011577]
exact_synonym: "genitalia missing" [FlyBase:FBgn0011577]
exact_synonym: "l(3)06464" [FlyBase:FBgn0011577]
xref_analog: UniProt:Q24114
relationship: sequence_of IMR:0002958 ! Dlp/Dally

[Term]
id: IMR:0001199
name: obsolete
comment: These are terms that have been removed from the active MoleculeRole ontology.
is_a: IMR:0000001 ! MoleculeRole

[Term]
id: IMR:0001200
name: TRAIL
exact_synonym: "Apo-2 ligand" []
exact_synonym: "Apo2L" []
exact_synonym: "TNF-related apoptosis inducing ligand" []
exact_synonym: "TNFSF10" []
is_a: IMR:0000021 ! TNF superfamily

[Term]
id: IMR:0001201
name: TRAIL-R1
exact_synonym: "death receptor 4" []
exact_synonym: "DR4" []
exact_synonym: "TNF-related apoptosis-inducing ligand receptor 1" []
exact_synonym: "TRAIL receptor-1" []
exact_synonym: "TRAIL-R1" []
is_a: IMR:0000056 ! TNFR family

[Term]
id: IMR:0001202
name: TRAIL-R2
exact_synonym: "death receptor 5" []
exact_synonym: "DR5" []
exact_synonym: "KILLER" []
exact_synonym: "TRAIL receptor-2" []
exact_synonym: "TRAIL-R2" []
exact_synonym: "TRICK2" []
is_a: IMR:0000056 ! TNFR family

[Term]
id: IMR:0001203
name: granzyme B
exact_synonym: "CTLA-1" []
is_a: IMR:0000304 ! protease

[Term]
id: IMR:0001204
name: Apaf-1
is_a: IMR:0000450 ! apoptosis regulator

[Term]
id: IMR:0001205
name: electron carrier protein
xref_analog: GO:0005489
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0001206
name: cytochrome c
exact_synonym: "Cyt c" []
is_a: IMR:0001205 ! electron carrier protein

[Term]
id: IMR:0001207
name: Smac
exact_synonym: "DIABLO" []
is_a: IMR:0000450 ! apoptosis regulator

[Term]
id: IMR:0001208
name: Bmf
is_a: IMR:0100709 ! BH3 subfamily

[Term]
id: IMR:0001209
name: DLC2
exact_synonym: "DLC8b" []
exact_synonym: "dynein light chain 2" []
is_a: IMR:0000200 ! dynein

[Term]
id: IMR:0001210
name: Noxa
is_a: IMR:0100709 ! BH3 subfamily

[Term]
id: IMR:0001211
name: Puma
exact_synonym: "bbc3" []
is_a: IMR:0100709 ! BH3 subfamily

[Term]
id: IMR:0001212
name: NMT1
exact_synonym: "EC 2.3.1.97" []
exact_synonym: "myristoyl-CoA:protein N-myristoyltransferase" []
is_a: IMR:0000955 ! acyltransferase

[Term]
id: IMR:0001213
name: DLC1
exact_synonym: "DLC8a" []
exact_synonym: "dynein light chain 1" []
exact_synonym: "PIN" []
exact_synonym: "protein inhibitor of neuronal nitric oxide synthase" []
is_a: IMR:0000200 ! dynein

[Term]
id: IMR:0001214
name: HDAC1_DROME
exact_synonym: "CG7471" [FlyBase:FBgn0015805]
exact_synonym: "dHDAC-1" [FlyBase:FBgn0015805]
exact_synonym: "dHDAC1" [FlyBase:FBgn0015805]
exact_synonym: "dmHDA401" [FlyBase:FBgn0015805]
exact_synonym: "DmHDAC1" [FlyBase:FBgn0015805]
exact_synonym: "dRPD3" [UniProt:Q94517, FlyBase:FBgn0015805]
exact_synonym: "dRpd3" [FlyBase:FBgn0015805]
exact_synonym: "E(var)3-64BC" [FlyBase:FBgn0015805]
exact_synonym: "EC 3.5.1.98" [UniProt:Q94517]
exact_synonym: "HD" [UniProt:Q94517]
exact_synonym: "HDAC" [FlyBase:FBgn0015805]
exact_synonym: "HDAC-1" [FlyBase:FBgn0015805]
exact_synonym: "HDAC1" [UniProt:Q94517, FlyBase:FBgn0015805]
exact_synonym: "Hdac1" [FlyBase:FBgn0015805]
exact_synonym: "Histone deacetylase Rpd3" [UniProt:Q94517]
exact_synonym: "l(3)04556" [FlyBase:FBgn0015805]
exact_synonym: "l(3)64Cc" [FlyBase:FBgn0015805]
exact_synonym: "Rpd3" [UniProt:Q94517, FlyBase:FBgn0015805]
exact_synonym: "RPD3" [FlyBase:FBgn0015805]
exact_synonym: "rpd3" [FlyBase:FBgn0015805]
exact_synonym: "Rpd3/HDAC" [FlyBase:FBgn0015805]
exact_synonym: "rpd[3]" [FlyBase:FBgn0015805]
exact_synonym: "Su(var)326" [FlyBase:FBgn0015805]
exact_synonym: "Su(var)328" [FlyBase:FBgn0015805]
exact_synonym: "Suppressor of variegation 326" [FlyBase:FBgn0015805]
xref_analog: UniProt:Q94517
relationship: sequence_of IMR:0001166 ! histone deacetylase

[Term]
id: IMR:0001215
name: Axin1
exact_synonym: "Axin" []
is_a: IMR:0000432 ! Axin

[Term]
id: IMR:0001216
name: Axin2
exact_synonym: "Axil" []
exact_synonym: "Axin-like protein" []
exact_synonym: "conductin" []
is_a: IMR:0000432 ! Axin

[Term]
id: IMR:0001217
name: AXN_DROME
exact_synonym: "0442/30" [FlyBase:FBgn0026597]
exact_synonym: "Axin" [UniProt:Q9V407, FlyBase:FBgn0026597]
exact_synonym: "axin" [FlyBase:FBgn0026597]
exact_synonym: "Axis inhibition protein" [UniProt:Q9V407]
exact_synonym: "Axn" [UniProt:Q9V407, FlyBase:FBgn0026597]
exact_synonym: "axn" [FlyBase:FBgn0026597]
exact_synonym: "CG7926" [FlyBase:FBgn0026597]
exact_synonym: "d-Axin" [UniProt:Q9V407]
exact_synonym: "D-Axin" [FlyBase:FBgn0026597]
exact_synonym: "D-axin" [FlyBase:FBgn0026597]
exact_synonym: "d-axin" [FlyBase:FBgn0026597]
exact_synonym: "dAxin" [UniProt:Q9V407, FlyBase:FBgn0026597]
exact_synonym: "DAxin" [FlyBase:FBgn0026597]
exact_synonym: "daxin" [FlyBase:FBgn0026597]
exact_synonym: "Daxin" [FlyBase:FBgn0026597]
exact_synonym: "din" [FlyBase:FBgn0026597]
exact_synonym: "l(3)S044230" [FlyBase:FBgn0026597]
xref_analog: UniProt:Q9V407
relationship: sequence_of IMR:0000432 ! Axin

[Term]
id: IMR:0001218
name: AXN1_XENLA
exact_synonym: "axin" [UniProt:Q9YGY0]
exact_synonym: "Axin-1" [UniProt:Q9YGY0]
exact_synonym: "axin1" [UniProt:Q9YGY0]
exact_synonym: "Axis inhibition protein 1" [UniProt:Q9YGY0]
exact_synonym: "axn" [UniProt:Q9YGY0]
exact_synonym: "xAxin" [UniProt:Q9YGY0]
xref_analog: UniProt:Q9YGY0
relationship: sequence_of IMR:0000432 ! Axin

[Term]
id: IMR:0001219
name: AXNR_XENLA
exact_synonym: "Axin-related protein" [UniProt:Q9PTP2]
exact_synonym: "xARP" [UniProt:Q9PTP2]
xref_analog: UniProt:Q9PTP2
relationship: sequence_of IMR:0000432 ! Axin

[Term]
id: IMR:0001220
name: DVL2_XENLA
exact_synonym: "Dishevelled-2" [UniProt:P51142]
exact_synonym: "dsh" [UniProt:P51142]
exact_synonym: "DSH homolog 2" [UniProt:P51142]
exact_synonym: "dvl2" [UniProt:P51142]
exact_synonym: "Segment polarity protein dishevelled homolog DVL-2" [UniProt:P51142]
exact_synonym: "Xdsh" [UniProt:P51142]
xref_analog: UniProt:P51142
relationship: sequence_of IMR:0100758 ! Dvl-2

[Term]
id: IMR:0001221
name: LIN44_CAEEL
exact_synonym: "Abnormal cell lineage protein 44" [UniProt:Q27886]
exact_synonym: "lin-44" [UniProt:Q27886]
exact_synonym: "Wnt protein" [UniProt:Q27886]
xref_analog: UniProt:Q27886
relationship: sequence_of IMR:0000003 ! Wnt

[Term]
id: IMR:0001222
name: Q18041_CAEEL
exact_synonym: "Abnormal cell lineage protein 18, confirmed by transcript evidence" [UniProt:Q18041]
exact_synonym: "lin-18" [UniProt:Q18041]
exact_synonym: "ryk" [UniProt:Q18041]
exact_synonym: "Tyrosine kinase receptor-related protein RYK" [UniProt:Q18041]
xref_analog: UniProt:Q18041
relationship: sequence_of IMR:0001154 ! Ryk

[Term]
id: IMR:0001223
name: Q94132_CAEEL
exact_synonym: "Abnormal cell lineage protein 17, isoform a, confirmed by transcript evidence" [UniProt:Q94132]
exact_synonym: "lin-17" [UniProt:Q94132]
exact_synonym: "Transmembrane receptor LIN-17" [UniProt:Q94132]
xref_analog: UniProt:Q94132
relationship: sequence_of IMR:0000055 ! Frizzled

[Term]
id: IMR:0001224
name: RYK_MOUSE
exact_synonym: "EC 2.7.10.1" [UniProt:Q01887]
exact_synonym: "ERK-3" [MGI:101766]
exact_synonym: "Kinase VIK" [UniProt:Q01887]
exact_synonym: "Met-related kinase" [UniProt:Q01887]
exact_synonym: "Mrk" [UniProt:Q01887]
exact_synonym: "NYK-R" [UniProt:Q01887]
exact_synonym: "receptor-like tyrosine kinase" [MGI:101766]
exact_synonym: "Ryk" [MGI:101766, UniProt:Q01887]
exact_synonym: "Tyrosine-protein kinase RYK" [UniProt:Q01887]
exact_synonym: "Vik" [MGI:101766]
xref_analog: UniProt:Q01887
relationship: sequence_of IMR:0001154 ! Ryk

[Term]
id: IMR:0001225
name: RYK_HUMAN
exact_synonym: "D3S3195" [HGNC:10481, EntrezGene:6259]
exact_synonym: "EC 2.7.10.1" [UniProt:P34925]
exact_synonym: "JTK5" [HGNC:10481, EntrezGene:6259]
exact_synonym: "JTK5A" [UniProt:P34925, EntrezGene:6259]
exact_synonym: "RYK" [HGNC:10481, UniProt:P34925, MIM:600524, EntrezGene:6259]
exact_synonym: "RYK receptor-like tyrosine kinase" [HGNC:10481, MIM:600524, EntrezGene:6259]
exact_synonym: "RYK1" [HGNC:10481, MIM:600524, EntrezGene:6259]
exact_synonym: "Tyrosine-protein kinase RYK" [UniProt:P34925]
xref_analog: UniProt:P34925
relationship: sequence_of IMR:0001154 ! Ryk

[Term]
id: IMR:0001226
name: adenosine and AMP deaminase
xref_analog: IPR:001365
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0001227
name: AMP deaminase
xref_analog: GO:0003876
xref_analog: IPR:006329
is_a: IMR:0001226 ! adenosine and AMP deaminase

[Term]
id: IMR:0001228
name: adenosine deaminase editase
exact_synonym: "double-stranded RNA adenosine deaminase" []
xref_analog: GO:0003726
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0001229
name: cytidine and deoxycytidylate deaminase
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0001230
name: RL8_MOUSE
exact_synonym: "60S ribosomal protein L8" [UniProt:P62918]
exact_synonym: "ribosomal protein L8" [MGI:1350927]
exact_synonym: "Rpl8" [MGI:1350927, UniProt:P62918]
xref_analog: UniProt:P62918
relationship: sequence_of IMR:0010500 ! 60S ribosomal protein L8

[Term]
id: IMR:0001231
name: RL8_HUMAN
exact_synonym: "60S ribosomal protein L8" [UniProt:P62917]
exact_synonym: "ribosomal protein L8" [MIM:604177, HGNC:10368, EntrezGene:6132]
exact_synonym: "RPL8" [MIM:604177, HGNC:10368, EntrezGene:6132, UniProt:P62917]
xref_analog: UniProt:P62917
relationship: sequence_of IMR:0010500 ! 60S ribosomal protein L8

[Term]
id: IMR:0001232
name: RS8_HUMAN
exact_synonym: "40S ribosomal protein S8" [UniProt:P62241]
exact_synonym: "ribosomal protein S8" [MIM:600357, HGNC:10441, EntrezGene:6202]
exact_synonym: "RPS8" [MIM:600357, HGNC:10441, UniProt:P62241, EntrezGene:6202]
xref_analog: UniProt:P62241
relationship: sequence_of IMR:0010564 ! 40S ribosomal protein S8

[Term]
id: IMR:0001233
name: RS8_MOUSE
exact_synonym: "40S ribosomal protein S8" [UniProt:P62242]
exact_synonym: "ribosomal protein S8" [MGI:98166]
exact_synonym: "Rps8" [UniProt:P62242, MGI:98166]
xref_analog: UniProt:P62242
relationship: sequence_of IMR:0010564 ! 40S ribosomal protein S8

[Term]
id: IMR:0001234
name: RL19_HUMAN
exact_synonym: "60S ribosomal protein L19" [UniProt:P84098]
exact_synonym: "DKFZp779D216" [EntrezGene:6143, HGNC:10312]
exact_synonym: "FLJ27452" [EntrezGene:6143, HGNC:10312]
exact_synonym: "MGC71997" [EntrezGene:6143, HGNC:10312]
exact_synonym: "ribosomal protein L19" [EntrezGene:6143, MIM:180466, HGNC:10312]
exact_synonym: "RPL19" [UniProt:P84098, EntrezGene:6143, MIM:180466, HGNC:10312]
xref_analog: UniProt:P84098
relationship: sequence_of IMR:0010469 ! 60S ribosomal protein L19

[Term]
id: IMR:0001235
name: RL19_MOUSE
exact_synonym: "60S ribosomal protein L19" [UniProt:P84099]
exact_synonym: "ribosomal protein L19" [MGI:98020]
exact_synonym: "Rpl19" [MGI:98020, UniProt:P84099]
xref_analog: UniProt:P84099
relationship: sequence_of IMR:0010469 ! 60S ribosomal protein L19

[Term]
id: IMR:0001236
name: RS21_MOUSE
exact_synonym: "40S ribosomal protein S21" [UniProt:Q9CQR2]
exact_synonym: "ribosomal protein S21" [MGI:1913731]
exact_synonym: "Rps21" [MGI:1913731, UniProt:Q9CQR2]
xref_analog: UniProt:Q9CQR2
relationship: sequence_of IMR:0010547 ! 40S ribosomal protein S21

[Term]
id: IMR:0001237
name: RS21_RAT
exact_synonym: "40S ribosomal protein S21" [UniProt:P05765]
exact_synonym: "ribosomal protein S21" [RGD:621038]
exact_synonym: "Rps21" [UniProt:P05765, RGD:621038]
xref_analog: UniProt:P05765
relationship: sequence_of IMR:0010547 ! 40S ribosomal protein S21

[Term]
id: IMR:0001238
name: RS23_HUMAN
exact_synonym: "40S ribosomal protein S23" [UniProt:P62266]
exact_synonym: "FLJ35016" [EntrezGene:6228]
exact_synonym: "ribosomal protein S23" [EntrezGene:6228, HGNC:10410, MIM:603683]
exact_synonym: "RPS23" [EntrezGene:6228, HGNC:10410, UniProt:P62266, MIM:603683]
xref_analog: UniProt:P62266
relationship: sequence_of IMR:0010548 ! 40S ribosomal protein S23

[Term]
id: IMR:0001239
name: RS23_MOUSE
exact_synonym: "40S ribosomal protein S23" [UniProt:P62267]
exact_synonym: "ribosomal protein S23" [MGI:1913725]
exact_synonym: "Rps23" [UniProt:P62267, MGI:1913725]
xref_analog: UniProt:P62267
relationship: sequence_of IMR:0010548 ! 40S ribosomal protein S23

[Term]
id: IMR:0001240
name: RS24_HUMAN
exact_synonym: "40S ribosomal protein S24" [UniProt:P62847]
exact_synonym: "DBA3" [EntrezGene:6229]
exact_synonym: "DKFZp686N1586" [EntrezGene:6229]
exact_synonym: "ribosomal protein S24" [HGNC:10411, MIM:602412, EntrezGene:6229]
exact_synonym: "RPS24" [HGNC:10411, UniProt:P62847, MIM:602412, EntrezGene:6229]
xref_analog: UniProt:P62847
relationship: sequence_of IMR:0010549 ! 40S ribosomal protein S24

[Term]
id: IMR:0001241
name: RS24_MOUSE
exact_synonym: "40S ribosomal protein S24" [UniProt:P62849]
exact_synonym: "MRP S24" [MGI:98147]
exact_synonym: "ribosomal protein S24" [MGI:98147]
exact_synonym: "Rps24" [UniProt:P62849, MGI:98147]
xref_analog: UniProt:P62849
relationship: sequence_of IMR:0010549 ! 40S ribosomal protein S24

[Term]
id: IMR:0001242
name: RS25_HUMAN
exact_synonym: "40S ribosomal protein S25" [UniProt:P62851]
exact_synonym: "ribosomal protein S25" [HGNC:10413, EntrezGene:6230, MIM:180465]
exact_synonym: "RPS25" [UniProt:P62851, HGNC:10413, EntrezGene:6230, MIM:180465]
xref_analog: UniProt:P62851
relationship: sequence_of IMR:0010550 ! 40S ribosomal protein S25

[Term]
id: IMR:0001243
name: RS25_MOUSE
exact_synonym: "40S ribosomal protein S25" [UniProt:P62852]
exact_synonym: "ribosomal protein S25" [MGI:1922867]
exact_synonym: "Rps25" [MGI:1922867, UniProt:P62852]
xref_analog: UniProt:P62852
relationship: sequence_of IMR:0010550 ! 40S ribosomal protein S25

[Term]
id: IMR:0001244
name: RS26_HUMAN
exact_synonym: "40S ribosomal protein S26" [UniProt:P62854]
exact_synonym: "DBA10" [EntrezGene:6231]
exact_synonym: "MGC104292" [EntrezGene:6231]
exact_synonym: "ribosomal protein S26" [HGNC:10414, MIM:603701, EntrezGene:6231]
exact_synonym: "RPS26" [HGNC:10414, UniProt:P62854, MIM:603701, EntrezGene:6231]
xref_analog: UniProt:P62854
relationship: sequence_of IMR:0010551 ! 40S ribosomal protein S26

[Term]
id: IMR:0001245
name: RS26_MOUSE
exact_synonym: "40S ribosomal protein S26" [UniProt:P62855]
exact_synonym: "ribosomal protein S26" [MGI:1351628]
exact_synonym: "Rps26" [UniProt:P62855, MGI:1351628]
xref_analog: UniProt:P62855
relationship: sequence_of IMR:0010551 ! 40S ribosomal protein S26

[Term]
id: IMR:0001246
name: SGG_DROME
exact_synonym: "anon-WO03040301.254" [FlyBase:FBgn0003371]
exact_synonym: "CG2621" [FlyBase:FBgn0003371]
exact_synonym: "DMSGG3" [FlyBase:FBgn0003371]
exact_synonym: "DMZ3K25Z" [FlyBase:FBgn0003371]
exact_synonym: "EC 2.7.11.1" [UniProt:P18431]
exact_synonym: "EG:155E2.3" [FlyBase:FBgn0003371]
exact_synonym: "EG:BACR7C10.8" [FlyBase:FBgn0003371]
exact_synonym: "Glycogen Synthase Kinase 3" [FlyBase:FBgn0003371]
exact_synonym: "glycogen synthase kinase 3Beta" [FlyBase:FBgn0003371]
exact_synonym: "GSK" [FlyBase:FBgn0003371]
exact_synonym: "GSK-3" [FlyBase:FBgn0003371]
exact_synonym: "GSK-3beta" [FlyBase:FBgn0003371]
exact_synonym: "Gsk3" [FlyBase:FBgn0003371]
exact_synonym: "GSK3" [FlyBase:FBgn0003371]
exact_synonym: "GSK3beta" [FlyBase:FBgn0003371]
exact_synonym: "GSKbeta" [FlyBase:FBgn0003371]
exact_synonym: "l(1)3Ba" [FlyBase:FBgn0003371]
exact_synonym: "l(1)G0055" [FlyBase:FBgn0003371]
exact_synonym: "l(1)G0183" [FlyBase:FBgn0003371]
exact_synonym: "l(1)G0263" [FlyBase:FBgn0003371]
exact_synonym: "l(1)G0335" [FlyBase:FBgn0003371]
exact_synonym: "l(1)zw3" [FlyBase:FBgn0003371]
exact_synonym: "Protein kinase shaggy" [UniProt:P18431]
exact_synonym: "Protein zeste-white 3" [UniProt:P18431]
exact_synonym: "sgg" [UniProt:P18431, FlyBase:FBgn0003371]
exact_synonym: "Sgg" [FlyBase:FBgn0003371]
exact_synonym: "sgg-zw3" [FlyBase:FBgn0003371]
exact_synonym: "SGG/GSK3b" [FlyBase:FBgn0003371]
exact_synonym: "sgg/zw3" [FlyBase:FBgn0003371]
exact_synonym: "sgg10" [FlyBase:FBgn0003371]
exact_synonym: "sgg39" [FlyBase:FBgn0003371]
exact_synonym: "sgg46" [FlyBase:FBgn0003371]
exact_synonym: "shaggy" [FlyBase:FBgn0003371]
exact_synonym: "shaggy-zeste white 3" [FlyBase:FBgn0003371]
exact_synonym: "zest-white 3" [FlyBase:FBgn0003371]
exact_synonym: "zeste white 3" [FlyBase:FBgn0003371]
exact_synonym: "Zeste white-3" [FlyBase:FBgn0003371]
exact_synonym: "zeste white-3" [FlyBase:FBgn0003371]
exact_synonym: "Zeste-white 3" [FlyBase:FBgn0003371]
exact_synonym: "zeste-white 3" [FlyBase:FBgn0003371]
exact_synonym: "zeste-white3" [FlyBase:FBgn0003371]
exact_synonym: "ZW-3" [FlyBase:FBgn0003371]
exact_synonym: "Zw-3" [FlyBase:FBgn0003371]
exact_synonym: "zw-3" [FlyBase:FBgn0003371]
exact_synonym: "zw3" [UniProt:P18431, FlyBase:FBgn0003371]
exact_synonym: "Zw3" [FlyBase:FBgn0003371]
exact_synonym: "ZW3" [FlyBase:FBgn0003371]
exact_synonym: "Zw3 kinase" [FlyBase:FBgn0003371]
exact_synonym: "zw3(sgg)" [FlyBase:FBgn0003371]
exact_synonym: "Zw3-sh" [FlyBase:FBgn0003371]
exact_synonym: "Zw3/GSK3" [FlyBase:FBgn0003371]
exact_synonym: "zw3/sgg" [FlyBase:FBgn0003371]
exact_synonym: "zw3[sgg]" [FlyBase:FBgn0003371]
exact_synonym: "Zw3[sgg]" [FlyBase:FBgn0003371]
exact_synonym: "zw[3]" [FlyBase:FBgn0003371]
xref_analog: UniProt:P18431
relationship: sequence_of IMR:0000257 ! GSK3

[Term]
id: IMR:0001247
name: GBP/Frat
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0001248
name: GBP_XENLA
exact_synonym: "GBP" [UniProt:O93343]
exact_synonym: "gbp" [UniProt:O93343]
exact_synonym: "GSK-3-binding protein" [UniProt:O93343]
xref_analog: UniProt:O93343
relationship: sequence_of IMR:0001247 ! GBP/Frat

[Term]
id: IMR:0001249
name: FRAT1_HUMAN
exact_synonym: "FLJ97193" [EntrezGene:10023]
exact_synonym: "FRAT-1" [UniProt:Q92837]
exact_synonym: "FRAT1" [EntrezGene:10023, HGNC:3944, MIM:602503, UniProt:Q92837]
exact_synonym: "frequently rearranged in advanced T-cell lymphomas" [EntrezGene:10023, HGNC:3944, MIM:602503]
exact_synonym: "Frequently rearranged in advanced T-cell lymphomas 1" [UniProt:Q92837]
exact_synonym: "Proto-oncogene FRAT1" [UniProt:Q92837]
xref_analog: UniProt:Q92837
relationship: sequence_of IMR:0001247 ! GBP/Frat

[Term]
id: IMR:0001250
name: FRAT2_HUMAN
exact_synonym: "FRAT-2" [UniProt:O75474]
exact_synonym: "FRAT2" [EntrezGene:23401, HGNC:16048, UniProt:O75474, MIM:605006]
exact_synonym: "Frequently rearranged in advanced T-cell lymphomas 2" [UniProt:O75474, MIM:605006]
exact_synonym: "frequently rearranged in advanced T-cell lymphomas 2" [EntrezGene:23401, HGNC:16048]
exact_synonym: "GSK-3-binding protein FRAT2" [UniProt:O75474]
exact_synonym: "MGC10562" [EntrezGene:23401]
xref_analog: UniProt:O75474
relationship: sequence_of IMR:0001247 ! GBP/Frat

[Term]
id: IMR:0001251
name: FRAT1_MOUSE
exact_synonym: "FRAT-1" [UniProt:P70339]
exact_synonym: "Frat1" [MGI:109450, UniProt:P70339]
exact_synonym: "frequently rearranged in advanced T-cell lymphomas" [MGI:109450]
exact_synonym: "Frequently rearranged in advanced T-cell lymphomas 1" [UniProt:P70339]
exact_synonym: "Proto-oncogene FRAT1" [UniProt:P70339]
xref_analog: UniProt:P70339
relationship: sequence_of IMR:0001247 ! GBP/Frat

[Term]
id: IMR:0001252
name: FRAT2_MOUSE
exact_synonym: "FRAT-2" [UniProt:Q8K025]
exact_synonym: "Frat2" [MGI:2673967, UniProt:Q8K025]
exact_synonym: "Frequently rearranged in advanced T-cell lymphomas 2" [UniProt:Q8K025]
exact_synonym: "frequently rearranged in advanced T-cell lymphomas 2" [MGI:2673967]
exact_synonym: "GSK-3-binding protein FRAT2" [UniProt:Q8K025]
xref_analog: UniProt:Q8K025
relationship: sequence_of IMR:0001247 ! GBP/Frat

[Term]
id: IMR:0001253
name: RS27_MOUSE
exact_synonym: "40S ribosomal protein S27" [UniProt:Q6ZWU9]
exact_synonym: "ribosomal protein S27" [MGI:1888676]
exact_synonym: "Rps27" [UniProt:Q6ZWU9, MGI:1888676]
xref_analog: UniProt:Q6ZWU9
relationship: sequence_of IMR:0010552 ! 40S ribosomal protein S27

[Term]
id: IMR:0001254
name: RS27_RAT
exact_synonym: "40S ribosomal protein S27" [UniProt:Q71TY3]
exact_synonym: "ribosomal protein S27" [RGD:621045]
exact_synonym: "Rps27" [UniProt:Q71TY3, RGD:621045]
exact_synonym: "S27-1" [UniProt:Q71TY3]
xref_analog: UniProt:Q71TY3
relationship: sequence_of IMR:0010552 ! 40S ribosomal protein S27

[Term]
id: IMR:0001255
name: RS27A_MOUSE
exact_synonym: "40S ribosomal protein S27a" [UniProt:P62983]
exact_synonym: "ribosomal protein S27A" [MGI:1925544]
exact_synonym: "Rps27a" [MGI:1925544, UniProt:P62983]
exact_synonym: "Uba80" [UniProt:P62983]
exact_synonym: "Ubcep1" [UniProt:P62983]
exact_synonym: "Ubiquitin" [UniProt:P62983]
exact_synonym: "Ubiquitin carboxyl extension protein 80" [UniProt:P62983]
exact_synonym: "Ubiquitin-40S ribosomal protein S27a" [UniProt:P62983]
xref_analog: UniProt:P62983
relationship: sequence_of IMR:0010447 ! 40S ribosomal protein S27a

[Term]
id: IMR:0001256
name: RS27A_RAT
exact_synonym: "40S ribosomal protein S27a" [UniProt:P62982]
exact_synonym: "ribosomal protein S27a" [RGD:620240]
exact_synonym: "Rps27a" [UniProt:P62982, RGD:620240]
exact_synonym: "Uba80" [UniProt:P62982]
exact_synonym: "Ubcep1" [UniProt:P62982]
exact_synonym: "Ubiquitin" [UniProt:P62982]
exact_synonym: "Ubiquitin carboxyl extension protein 80" [UniProt:P62982]
exact_synonym: "Ubiquitin-40S ribosomal protein S27a" [UniProt:P62982]
xref_analog: UniProt:P62982
relationship: sequence_of IMR:0010447 ! 40S ribosomal protein S27a

[Term]
id: IMR:0001257
name: RS28_MOUSE
exact_synonym: "40S ribosomal protein S28" [UniProt:P62858]
exact_synonym: "ribosomal protein S28" [MGI:1859516]
exact_synonym: "Rps28" [MGI:1859516, UniProt:P62858]
xref_analog: UniProt:P62858
relationship: sequence_of IMR:0010553 ! 40S ribosomal protein S28

[Term]
id: IMR:0001258
name: RS28_HUMAN
exact_synonym: "40S ribosomal protein S28" [UniProt:P62857]
exact_synonym: "ribosomal protein S28" [MIM:603685, HGNC:10418, EntrezGene:6234]
exact_synonym: "RPS28" [MIM:603685, HGNC:10418, UniProt:P62857, EntrezGene:6234]
xref_analog: UniProt:P62857
relationship: sequence_of IMR:0010553 ! 40S ribosomal protein S28

[Term]
id: IMR:0001259
name: RS29_HUMAN
exact_synonym: "40S ribosomal protein S29" [UniProt:P62273]
exact_synonym: "ribosomal protein S29" [HGNC:10419, EntrezGene:6235, MIM:603633]
exact_synonym: "RPS29" [HGNC:10419, UniProt:P62273, EntrezGene:6235, MIM:603633]
xref_analog: UniProt:P62273
relationship: sequence_of IMR:0010554 ! 40S ribosomal protein S29

[Term]
id: IMR:0001260
name: RS29_MOUSE
exact_synonym: "40S ribosomal protein S29" [UniProt:P62274]
exact_synonym: "ribosomal protein S29" [MGI:107681]
exact_synonym: "Rps29" [UniProt:P62274, MGI:107681]
exact_synonym: "S29 ribosomal protein" [MGI:107681]
xref_analog: UniProt:P62274
relationship: sequence_of IMR:0010554 ! 40S ribosomal protein S29

[Term]
id: IMR:0001261
name: RS13_HUMAN
exact_synonym: "40S ribosomal protein S13" [UniProt:P62277]
exact_synonym: "ribosomal protein S13" [EntrezGene:6207, MIM:180476, HGNC:10386]
exact_synonym: "RPS13" [EntrezGene:6207, MIM:180476, HGNC:10386, UniProt:P62277]
xref_analog: UniProt:P62277
relationship: sequence_of IMR:0010538 ! 40S ribosomal protein S13

[Term]
id: IMR:0001262
name: RS13_MOUSE
exact_synonym: "40S ribosomal protein S13" [UniProt:P62301]
exact_synonym: "ribosomal protein S13" [MGI:1915302]
exact_synonym: "Rps13" [MGI:1915302, UniProt:P62301]
xref_analog: UniProt:P62301
relationship: sequence_of IMR:0010538 ! 40S ribosomal protein S13

[Term]
id: IMR:0001263
name: RS14_HUMAN
exact_synonym: "40S ribosomal protein S14" [UniProt:P62263]
exact_synonym: "EMETINE RESISTANCE GENE" [MIM:130620]
exact_synonym: "EMTB" [EntrezGene:6208, MIM:130620, HGNC:10387]
exact_synonym: "ribosomal protein S14" [EntrezGene:6208, MIM:130620, HGNC:10387]
exact_synonym: "RPS14" [EntrezGene:6208, MIM:130620, UniProt:P62263, HGNC:10387]
xref_analog: UniProt:P62263
relationship: sequence_of IMR:0010539 ! 40S ribosomal protein S14

[Term]
id: IMR:0001264
name: RS14_RAT
exact_synonym: "40S ribosomal protein S14" [UniProt:P13471]
exact_synonym: "ribosomal protein S14" [RGD:62025]
exact_synonym: "Rps14" [RGD:62025, UniProt:P13471]
xref_analog: UniProt:P13471
relationship: sequence_of IMR:0010539 ! 40S ribosomal protein S14

[Term]
id: IMR:0001265
name: RS15A_HUMAN
exact_synonym: "40S ribosomal protein S15a" [UniProt:P62244]
exact_synonym: "FLJ27457" [EntrezGene:6210]
exact_synonym: "MGC111208" [EntrezGene:6210]
exact_synonym: "ribosomal protein S15a" [EntrezGene:6210, MIM:603674, HGNC:10389]
exact_synonym: "RPS15A" [EntrezGene:6210, MIM:603674, HGNC:10389, UniProt:P62244]
exact_synonym: "S15a" [EntrezGene:6210]
xref_analog: UniProt:P62244
relationship: sequence_of IMR:0010545 ! 40S ribosomal protein S15a

[Term]
id: IMR:0001266
name: RS15A_MOUSE
exact_synonym: "40S ribosomal protein S15a" [UniProt:P62245]
exact_synonym: "ribosomal protein S15A" [MGI:2389091]
exact_synonym: "Rps15a" [UniProt:P62245, MGI:2389091]
xref_analog: UniProt:P62245
relationship: sequence_of IMR:0010545 ! 40S ribosomal protein S15a

[Term]
id: IMR:0001267
name: RS15_HUMAN
exact_synonym: "40S ribosomal protein S15" [UniProt:P62841]
exact_synonym: "MGC111130" [HGNC:10388, EntrezGene:6209]
exact_synonym: "RAT INSULINOMA GENE HOMOLOG" [MIM:180535]
exact_synonym: "ribosomal protein S15" [MIM:180535, HGNC:10388, EntrezGene:6209]
exact_synonym: "RIG" [MIM:180535, HGNC:10388, EntrezGene:6209, UniProt:P62841]
exact_synonym: "RIG protein" [UniProt:P62841]
exact_synonym: "RPS15" [MIM:180535, HGNC:10388, EntrezGene:6209, UniProt:P62841]
xref_analog: UniProt:P62841
relationship: sequence_of IMR:0010540 ! 40S ribosomal protein S15

[Term]
id: IMR:0001268
name: RS15_MOUSE
exact_synonym: "40S ribosomal protein S15" [UniProt:P62843]
exact_synonym: "insulinoma" [MGI:98117]
exact_synonym: "rat insulinoma gene" [MGI:98117]
exact_synonym: "ribosomal protein S15" [MGI:98117]
exact_synonym: "Rig" [UniProt:P62843]
exact_synonym: "rig" [MGI:98117]
exact_synonym: "RIG protein" [UniProt:P62843]
exact_synonym: "Rps15" [UniProt:P62843, MGI:98117]
xref_analog: UniProt:P62843
relationship: sequence_of IMR:0010540 ! 40S ribosomal protein S15

[Term]
id: IMR:0001269
name: RS16_HUMAN
exact_synonym: "40S ribosomal protein S16" [UniProt:P62249]
exact_synonym: "ribosomal protein S16" [MIM:603675, HGNC:10396, EntrezGene:6217]
exact_synonym: "RPS16" [MIM:603675, HGNC:10396, UniProt:P62249, EntrezGene:6217]
xref_analog: UniProt:P62249
relationship: sequence_of IMR:0010541 ! 40S ribosomal protein S16

[Term]
id: IMR:0001270
name: RS16_MOUSE
exact_synonym: "40S ribosomal protein S16" [UniProt:P14131]
exact_synonym: "ribosomal protein S16" [MGI:98118]
exact_synonym: "Rps16" [MGI:98118, UniProt:P14131]
xref_analog: UniProt:P14131
relationship: sequence_of IMR:0010541 ! 40S ribosomal protein S16

[Term]
id: IMR:0001271
name: RS17_MOUSE
exact_synonym: "40S ribosomal protein S17" [UniProt:P63276]
exact_synonym: "ribosomal protein S17" [MGI:1309526]
exact_synonym: "Rps17" [UniProt:P63276, MGI:1309526]
xref_analog: UniProt:P63276
relationship: sequence_of IMR:0010542 ! 40S ribosomal protein S17

[Term]
id: IMR:0001272
name: RS17_RAT
exact_synonym: "40S ribosomal protein S17" [UniProt:P04644]
exact_synonym: "ribosomal protein S17" [RGD:62027]
exact_synonym: "Rps17" [RGD:62027, UniProt:P04644]
xref_analog: UniProt:P04644
relationship: sequence_of IMR:0010542 ! 40S ribosomal protein S17

[Term]
id: IMR:0001273
name: RS18_HUMAN
exact_synonym: "40S ribosomal protein S18" [UniProt:P62269]
exact_synonym: "D6S218E" [UniProt:P62269, EntrezGene:6222]
exact_synonym: "HKE3" [HGNC:10401, EntrezGene:6222]
exact_synonym: "Ke-3" [UniProt:P62269]
exact_synonym: "KE-3" [HGNC:10401, EntrezGene:6222]
exact_synonym: "Ke3" [UniProt:P62269]
exact_synonym: "KE3" [HGNC:10401, EntrezGene:6222]
exact_synonym: "MGC117351" [EntrezGene:6222]
exact_synonym: "MGC126835" [EntrezGene:6222]
exact_synonym: "MGC126837" [EntrezGene:6222]
exact_synonym: "ribosomal protein S18" [HGNC:10401, EntrezGene:6222, MIM:180473]
exact_synonym: "RPS18" [HGNC:10401, UniProt:P62269, EntrezGene:6222, MIM:180473]
xref_analog: UniProt:P62269
relationship: sequence_of IMR:0010543 ! 40S ribosomal protein S18

[Term]
id: IMR:0001274
name: RS18_MOUSE
exact_synonym: "40S ribosomal protein S18" [UniProt:P62270]
exact_synonym: "H-2Ke3" [MGI:98146]
exact_synonym: "H2-Ke3" [MGI:98146]
exact_synonym: "Ke-3" [UniProt:P62270]
exact_synonym: "Ke3" [UniProt:P62270]
exact_synonym: "ribosomal protein S18" [MGI:98146]
exact_synonym: "Rps18" [UniProt:P62270, MGI:98146]
xref_analog: UniProt:P62270
relationship: sequence_of IMR:0010543 ! 40S ribosomal protein S18

[Term]
id: IMR:0001275
name: RS19_MOUSE
exact_synonym: "40S ribosomal protein S19" [UniProt:Q9CZX8]
exact_synonym: "Dsk3" [MGI:1333780]
exact_synonym: "ribosomal protein S19" [MGI:1333780]
exact_synonym: "Rps19" [MGI:1333780, UniProt:Q9CZX8]
xref_analog: UniProt:Q9CZX8
relationship: sequence_of IMR:0010544 ! 40S ribosomal protein S19

[Term]
id: IMR:0001276
name: RS19_RAT
exact_synonym: "40S ribosomal protein S19" [UniProt:P17074]
exact_synonym: "ribosomal protein S19" [RGD:68440]
exact_synonym: "Rps19" [RGD:68440, UniProt:P17074]
xref_analog: UniProt:P17074
relationship: sequence_of IMR:0010544 ! 40S ribosomal protein S19

[Term]
id: IMR:0001277
name: RS2_MOUSE
exact_synonym: "40S ribosomal protein S2" [UniProt:P25444]
exact_synonym: "40S ribosomal protein S4" [UniProt:P25444]
exact_synonym: "Llrep3" [UniProt:P25444, MGI:105110]
exact_synonym: "Protein LLRep3" [UniProt:P25444]
exact_synonym: "ribosomal protein S2" [MGI:105110]
exact_synonym: "Rps2" [UniProt:P25444, MGI:105110]
exact_synonym: "Rps4" [UniProt:P25444]
xref_analog: UniProt:P25444
relationship: sequence_of IMR:0010555 ! 40S ribosomal protein S2

[Term]
id: IMR:0001278
name: RS2_RAT
exact_synonym: "40S ribosomal protein S2" [UniProt:P27952]
exact_synonym: "ribosomal protein S2" [RGD:619887]
exact_synonym: "Rps2" [RGD:619887, UniProt:P27952]
xref_analog: UniProt:P27952
relationship: sequence_of IMR:0010555 ! 40S ribosomal protein S2

[Term]
id: IMR:0001279
name: RS20_HUMAN
exact_synonym: "40S ribosomal protein S20" [UniProt:P60866]
exact_synonym: "FLJ27451" [EntrezGene:6224]
exact_synonym: "MGC102930" [EntrezGene:6224]
exact_synonym: "ribosomal protein S20" [MIM:603682, EntrezGene:6224, HGNC:10405]
exact_synonym: "RPS20" [MIM:603682, UniProt:P60866, EntrezGene:6224, HGNC:10405]
xref_analog: UniProt:P60866
relationship: sequence_of IMR:0010546 ! 40S ribosomal protein S20

[Term]
id: IMR:0001280
name: RS20_MOUSE
exact_synonym: "40S ribosomal protein S20" [UniProt:P60867]
exact_synonym: "Dsk4" [MGI:1914677]
exact_synonym: "ribosomal protein S20" [MGI:1914677]
exact_synonym: "Rps20" [MGI:1914677, UniProt:P60867]
xref_analog: UniProt:P60867
relationship: sequence_of IMR:0010546 ! 40S ribosomal protein S20

[Term]
id: IMR:0001281
name: RS30_HUMAN
exact_synonym: "40S ribosomal protein S30" [UniProt:P62861]
exact_synonym: "asr1" [EntrezGene:2197, HGNC:3597]
exact_synonym: "FAU" [UniProt:P62861, MIM:134690, EntrezGene:2197, HGNC:3597]
exact_synonym: "FAU GENE" [MIM:134690]
exact_synonym: "FAU1" [EntrezGene:2197]
exact_synonym: "FBR-MuSV ASSOCIATED UBIQUITOUSLY EXPRESSED GENE" [MIM:134690]
exact_synonym: "Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed" [EntrezGene:2197, HGNC:3597]
exact_synonym: "FLJ22986" [EntrezGene:2197, HGNC:3597]
exact_synonym: "Fub1" [EntrezGene:2197, HGNC:3597]
exact_synonym: "Fubi" [EntrezGene:2197, HGNC:3597]
exact_synonym: "MNSFbeta" [EntrezGene:2197, HGNC:3597]
exact_synonym: "RPS30" [EntrezGene:2197, HGNC:3597]
xref_analog: UniProt:P62861
relationship: sequence_of IMR:0010556 ! 40S ribosomal protein S30

[Term]
id: IMR:0001282
name: RS30_MOUSE
exact_synonym: "40S ribosomal protein S30" [UniProt:P62862]
exact_synonym: "Fau" [UniProt:P62862, MGI:102547]
exact_synonym: "Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)" [MGI:102547]
exact_synonym: "MNSFbeta" [MGI:102547]
exact_synonym: "monoclonal nonspecific suppressor             factor betamonoclonal nonspecific suppressor factor beta" [MGI:102547]
xref_analog: UniProt:P62862
relationship: sequence_of IMR:0010556 ! 40S ribosomal protein S30

[Term]
id: IMR:0001283
name: RS3A_MOUSE
exact_synonym: "40S ribosomal protein S3a" [UniProt:P97351]
exact_synonym: "Protein TU-11" [UniProt:P97351]
exact_synonym: "ribosomal protein S3A" [MGI:1202063]
exact_synonym: "Rps3a" [MGI:1202063, UniProt:P97351]
xref_analog: UniProt:P97351
relationship: sequence_of IMR:0010557 ! 40S ribosomal protein S3a

[Term]
id: IMR:0001284
name: RS3A_RAT
exact_synonym: "40S ribosomal protein S3a" [UniProt:P49242]
exact_synonym: "40S ribosomal protein S3b" [UniProt:P49242]
exact_synonym: "Fte-1" [UniProt:P49242]
exact_synonym: "Fte1" [UniProt:P49242]
exact_synonym: "ribosomal protein S3a" [RGD:62078]
exact_synonym: "Rps3a" [UniProt:P49242, RGD:62078]
exact_synonym: "V-fos transformation effector protein" [UniProt:P49242]
xref_analog: UniProt:P49242
relationship: sequence_of IMR:0010557 ! 40S ribosomal protein S3a

[Term]
id: IMR:0001285
name: RS3_MOUSE
exact_synonym: "40S ribosomal protein S3" [UniProt:P62908]
exact_synonym: "D7Ertd795e" [MGI:1350917]
exact_synonym: "ribosomal protein S3" [MGI:1350917]
exact_synonym: "Rps3" [MGI:1350917, UniProt:P62908]
xref_analog: UniProt:P62908
relationship: sequence_of IMR:0010558 ! 40S ribosomal protein S3

[Term]
id: IMR:0001286
name: RS3_RAT
exact_synonym: "40S ribosomal protein S3" [UniProt:P62909]
exact_synonym: "ribosomal protein S3" [RGD:619888]
exact_synonym: "Rps3" [UniProt:P62909, RGD:619888]
xref_analog: UniProt:P62909
relationship: sequence_of IMR:0010558 ! 40S ribosomal protein S3

[Term]
id: IMR:0001287
name: RS4X_HUMAN
exact_synonym: "40S ribosomal protein S4, X isoform" [UniProt:P62701]
exact_synonym: "CCG2" [EntrezGene:6191, UniProt:P62701, HGNC:10424, MIM:312760]
exact_synonym: "CELL CYCLE GENE 2" [MIM:312760]
exact_synonym: "DXS306" [EntrezGene:6191, HGNC:10424]
exact_synonym: "FLJ40595" [EntrezGene:6191, HGNC:10424]
exact_synonym: "ribosomal protein S4, X-linked" [EntrezGene:6191, HGNC:10424, MIM:312760]
exact_synonym: "RPS4" [EntrezGene:6191, UniProt:P62701, HGNC:10424]
exact_synonym: "RPS4X" [EntrezGene:6191, UniProt:P62701, HGNC:10424]
exact_synonym: "RPS4X SINGLE-COPY ABUNDANT mRNA" [MIM:312760]
exact_synonym: "SCAR" [EntrezGene:6191, UniProt:P62701, HGNC:10424, MIM:312760]
exact_synonym: "SCR10" [EntrezGene:6191, UniProt:P62701, HGNC:10424]
exact_synonym: "Single copy abundant mRNA protein" [UniProt:P62701]
xref_analog: UniProt:P62701
relationship: sequence_of IMR:0010560 ! 40S ribosomal protein S4, X isoform

[Term]
id: IMR:0001288
name: RS4X_MOUSE
exact_synonym: "40S ribosomal protein S4, X isoform" [UniProt:P62702]
exact_synonym: "ribosomal protein S4, X-linked" [MGI:98158]
exact_synonym: "Rps4" [UniProt:P62702, MGI:98158]
exact_synonym: "Rps4-1" [MGI:98158]
exact_synonym: "Rps4x" [UniProt:P62702, MGI:98158]
xref_analog: UniProt:P62702
relationship: sequence_of IMR:0010560 ! 40S ribosomal protein S4, X isoform

[Term]
id: IMR:0001289
name: RS5_MOUSE
exact_synonym: "40S ribosomal protein S5" [UniProt:P97461]
exact_synonym: "40S ribosomal protein S5, N-terminally processed" [UniProt:P97461]
exact_synonym: "ribosomal protein S5" [MGI:1097682]
exact_synonym: "Rps5" [UniProt:P97461, MGI:1097682]
exact_synonym: "S5 ribosomal protein" [MGI:1097682]
xref_analog: UniProt:P97461
relationship: sequence_of IMR:0010561 ! 40S ribosomal protein S5

[Term]
id: IMR:0001290
name: RS5_RAT
exact_synonym: "40S ribosomal protein S5" [UniProt:P24050]
exact_synonym: "40S ribosomal protein S5, N-terminally processed" [UniProt:P24050]
exact_synonym: "ribosomal protein S5" [RGD:3601]
exact_synonym: "Rps5" [RGD:3601, UniProt:P24050]
xref_analog: UniProt:P24050
relationship: sequence_of IMR:0010561 ! 40S ribosomal protein S5

[Term]
id: IMR:0001291
name: RS6_HUMAN
exact_synonym: "40S ribosomal protein S6" [UniProt:P62753]
exact_synonym: "Phosphoprotein NP33" [UniProt:P62753]
exact_synonym: "ribosomal protein S6" [MIM:180460, HGNC:10429, EntrezGene:6194]
exact_synonym: "RPS6" [UniProt:P62753, MIM:180460, HGNC:10429, EntrezGene:6194]
xref_analog: UniProt:P62753
relationship: sequence_of IMR:0100711 ! 40S ribosomal protein S6

[Term]
id: IMR:0001292
name: RS6_MOUSE
exact_synonym: "40S ribosomal protein S6" [UniProt:P62754]
exact_synonym: "Phosphoprotein NP33" [UniProt:P62754]
exact_synonym: "ribosomal protein S6" [MGI:98159]
exact_synonym: "Rps6" [UniProt:P62754, MGI:98159]
xref_analog: UniProt:P62754
relationship: sequence_of IMR:0100711 ! 40S ribosomal protein S6

[Term]
id: IMR:0001293
name: RS7_HUMAN
exact_synonym: "40S ribosomal protein S7" [UniProt:P62081]
exact_synonym: "DBA8" [EntrezGene:6201]
exact_synonym: "ribosomal protein S7" [EntrezGene:6201, HGNC:10440, MIM:603658]
exact_synonym: "RPS7" [EntrezGene:6201, HGNC:10440, MIM:603658, UniProt:P62081]
xref_analog: UniProt:P62081
relationship: sequence_of IMR:0010563 ! 40S ribosomal protein S7

[Term]
id: IMR:0001294
name: RS7_MOUSE
exact_synonym: "40S ribosomal protein S7" [UniProt:P62082]
exact_synonym: "ribosomal protein S7" [MGI:1333818]
exact_synonym: "Rps7" [UniProt:P62082, MGI:1333818]
exact_synonym: "S7" [MGI:1333818]
xref_analog: UniProt:P62082
relationship: sequence_of IMR:0010563 ! 40S ribosomal protein S7

[Term]
id: IMR:0001295
name: RS9_MOUSE
exact_synonym: "40S ribosomal protein S9" [UniProt:Q6ZWN5]
exact_synonym: "ribosomal protein S9" [MGI:1924096]
exact_synonym: "Rps9" [MGI:1924096, UniProt:Q6ZWN5]
xref_analog: UniProt:Q6ZWN5
relationship: sequence_of IMR:0010565 ! 40S ribosomal protein S9

[Term]
id: IMR:0001296
name: RS9_RAT
exact_synonym: "40S ribosomal protein S9" [UniProt:P29314]
exact_synonym: "ribosomal protein S9" [RGD:619889]
exact_synonym: "Rps9" [UniProt:P29314, RGD:619889]
xref_analog: UniProt:P29314
relationship: sequence_of IMR:0010565 ! 40S ribosomal protein S9

[Term]
id: IMR:0001297
name: RSSA_MOUSE
exact_synonym: "37 kDa laminin receptor precursor" [UniProt:P14206]
exact_synonym: "37 kDa oncofetal antigen" [UniProt:P14206]
exact_synonym: "37/67 kDa laminin receptor" [UniProt:P14206]
exact_synonym: "37LRP" [UniProt:P14206]
exact_synonym: "40S ribosomal protein SA" [UniProt:P14206]
exact_synonym: "67 kDa laminin receptor" [UniProt:P14206]
exact_synonym: "67LR" [UniProt:P14206]
exact_synonym: "67lr" [MGI:105381]
exact_synonym: "Laminin receptor 1" [UniProt:P14206]
exact_synonym: "Laminin-binding protein precursor p40" [UniProt:P14206]
exact_synonym: "LamR" [UniProt:P14206]
exact_synonym: "Lamr" [MGI:105381]
exact_synonym: "Lamr1" [UniProt:P14206, MGI:105381]
exact_synonym: "Lamrl1" [MGI:105381]
exact_synonym: "LBP/p40" [UniProt:P14206]
exact_synonym: "LRP/LR" [UniProt:P14206]
exact_synonym: "OFA/iLRP" [UniProt:P14206]
exact_synonym: "P40-3" [MGI:105381]
exact_synonym: "P40-8" [UniProt:P14206, MGI:105381]
exact_synonym: "ribosomal protein SA" [MGI:105381]
exact_synonym: "Rpsa" [UniProt:P14206, MGI:105381]
xref_analog: UniProt:P14206
relationship: sequence_of IMR:0010567 ! 40S ribosomal protein SA

[Term]
id: IMR:0001298
name: RSSA_RAT
exact_synonym: "37 kDa laminin receptor precursor" [UniProt:P38983]
exact_synonym: "37/67 kDa laminin receptor" [UniProt:P38983]
exact_synonym: "37LRP" [UniProt:P38983]
exact_synonym: "40S ribosomal protein SA" [UniProt:P38983]
exact_synonym: "67 kDa laminin receptor" [UniProt:P38983]
exact_synonym: "67LR" [UniProt:P38983]
exact_synonym: "Laminin receptor 1" [UniProt:P38983]
exact_synonym: "Laminin-binding protein precursor p40" [UniProt:P38983]
exact_synonym: "LamR" [UniProt:P38983]
exact_synonym: "Lamr1" [UniProt:P38983]
exact_synonym: "LBP/p40" [UniProt:P38983]
exact_synonym: "LRP/LR" [UniProt:P38983]
exact_synonym: "ribosomal protein SA" [RGD:71026]
exact_synonym: "Rpsa" [RGD:71026, UniProt:P38983]
xref_analog: UniProt:P38983
relationship: sequence_of IMR:0010567 ! 40S ribosomal protein SA

[Term]
id: IMR:0001299
name: RL11_HUMAN
exact_synonym: "60S ribosomal protein L11" [UniProt:P62913]
exact_synonym: "CLL-associated antigen KW-12" [UniProt:P62913]
exact_synonym: "DBA7" [EntrezGene:6135]
exact_synonym: "GIG34" [EntrezGene:6135]
exact_synonym: "ribosomal protein L11" [MIM:604175, EntrezGene:6135, HGNC:10301]
exact_synonym: "RPL11" [MIM:604175, EntrezGene:6135, HGNC:10301, UniProt:P62913]
xref_analog: UniProt:P62913
relationship: sequence_of IMR:0010462 ! 60S ribosomal protein L11

[Term]
id: IMR:0001300
name: RL11_MOUSE
exact_synonym: "60S ribosomal protein L11" [UniProt:Q9CXW4]
exact_synonym: "ribosomal protein L11" [MGI:1914275]
exact_synonym: "Rpl11" [MGI:1914275, UniProt:Q9CXW4]
xref_analog: UniProt:Q9CXW4
relationship: sequence_of IMR:0010462 ! 60S ribosomal protein L11

[Term]
id: IMR:0001301
name: RL15_HUMAN
exact_synonym: "60S ribosomal protein L15" [UniProt:P61313]
exact_synonym: "EC45" [HGNC:10306, EntrezGene:6138, UniProt:P61313]
exact_synonym: "FLJ26304" [EntrezGene:6138]
exact_synonym: "MGC88603" [EntrezGene:6138]
exact_synonym: "ribosomal protein L15" [HGNC:10306, EntrezGene:6138, MIM:604174]
exact_synonym: "RPL10" [HGNC:10306, EntrezGene:6138]
exact_synonym: "RPL15" [HGNC:10306, EntrezGene:6138, MIM:604174, UniProt:P61313]
exact_synonym: "RPLY10" [HGNC:10306, EntrezGene:6138]
exact_synonym: "RPYL10" [HGNC:10306, EntrezGene:6138]
xref_analog: UniProt:P61313
relationship: sequence_of IMR:0010466 ! 60S ribosomal protein L15

[Term]
id: IMR:0001302
name: RL15_MOUSE
exact_synonym: "60S ribosomal protein L15" [UniProt:Q9CZM2]
exact_synonym: "ribosomal protein L15" [MGI:1913730]
exact_synonym: "Rpl15" [MGI:1913730, UniProt:Q9CZM2]
xref_analog: UniProt:Q9CZM2
relationship: sequence_of IMR:0010466 ! 60S ribosomal protein L15

[Term]
id: IMR:0001303
name: RL23_HUMAN
exact_synonym: "60S ribosomal protein L17" [UniProt:P62829]
exact_synonym: "60S ribosomal protein L23" [UniProt:P62829]
exact_synonym: "MGC111167" [EntrezGene:9349]
exact_synonym: "MGC117346" [EntrezGene:9349]
exact_synonym: "MGC72008" [EntrezGene:9349]
exact_synonym: "ribosomal protein L23" [EntrezGene:9349, MIM:603662, HGNC:10316]
exact_synonym: "rpL17" [EntrezGene:9349, HGNC:10316]
exact_synonym: "RPL23" [EntrezGene:9349, MIM:603662, HGNC:10316, UniProt:P62829]
xref_analog: UniProt:P62829
relationship: sequence_of IMR:0010473 ! 60S ribosomal protein L23

[Term]
id: IMR:0001304
name: RL23_MOUSE
exact_synonym: "60S ribosomal protein L23" [UniProt:P62830]
exact_synonym: "ribosomal protein L23" [MGI:1929455]
exact_synonym: "Rpl23" [MGI:1929455, UniProt:P62830]
xref_analog: UniProt:P62830
relationship: sequence_of IMR:0010473 ! 60S ribosomal protein L23

[Term]
id: IMR:0001305
name: RL23A_HUMAN
exact_synonym: "60S ribosomal protein L23a" [UniProt:P62750]
exact_synonym: "FLJ27455" [EntrezGene:6147]
exact_synonym: "MDA20" [EntrezGene:6147]
exact_synonym: "ribosomal protein L23a" [EntrezGene:6147, MIM:602326, HGNC:10317]
exact_synonym: "RPL23A" [EntrezGene:6147, MIM:602326, HGNC:10317, UniProt:P62750]
xref_analog: UniProt:P62750
relationship: sequence_of IMR:0010480 ! 60S ribosomal protein L23a

[Term]
id: IMR:0001306
name: RL23A_MOUSE
exact_synonym: "60S ribosomal protein L23a" [UniProt:P62751]
exact_synonym: "MDA20" [MGI:3040672]
exact_synonym: "ribosomal protein L23A" [MGI:3040672]
exact_synonym: "Rpl23a" [MGI:3040672, UniProt:P62751]
xref_analog: UniProt:P62751
relationship: sequence_of IMR:0010480 ! 60S ribosomal protein L23a

[Term]
id: IMR:0001307
name: RL24_HUMAN
exact_synonym: "60S ribosomal protein L24" [UniProt:P83731]
exact_synonym: "60S ribosomal protein L30" [UniProt:P83731]
exact_synonym: "ribosomal protein L24" [HGNC:10325, EntrezGene:6152, MIM:604180]
exact_synonym: "RPL24" [HGNC:10325, UniProt:P83731, EntrezGene:6152, MIM:604180]
xref_analog: UniProt:P83731
relationship: sequence_of IMR:0010474 ! 60S ribosomal protein L24

[Term]
id: IMR:0001308
name: RL24_MOUSE
exact_synonym: "60S ribosomal protein L24" [UniProt:Q8BP67]
exact_synonym: "Bst" [MGI:1915443]
exact_synonym: "ribosomal protein L24" [MGI:1915443]
exact_synonym: "Rpl24" [MGI:1915443, UniProt:Q8BP67]
xref_analog: UniProt:Q8BP67
relationship: sequence_of IMR:0010474 ! 60S ribosomal protein L24

[Term]
id: IMR:0001309
name: RL26_HUMAN
exact_synonym: "60S ribosomal protein L26" [UniProt:P61254]
exact_synonym: "ribosomal protein L26" [EntrezGene:6154, MIM:603704, HGNC:10327]
exact_synonym: "RPL26" [EntrezGene:6154, UniProt:P61254, MIM:603704, HGNC:10327]
xref_analog: UniProt:P61254
relationship: sequence_of IMR:0010475 ! 60S ribosomal protein L26

[Term]
id: IMR:0001310
name: RL26_RAT
exact_synonym: "60S ribosomal protein L26" [UniProt:P12749]
exact_synonym: "ribosomal protein L26" [RGD:1310607]
exact_synonym: "Rpl26" [RGD:1310607, UniProt:P12749]
xref_analog: UniProt:P12749
relationship: sequence_of IMR:0010475 ! 60S ribosomal protein L26

[Term]
id: IMR:0001311
name: RL27_HUMAN
exact_synonym: "60S ribosomal protein L27" [UniProt:P61353]
exact_synonym: "ribosomal protein L27" [EntrezGene:6155, HGNC:10328, MIM:607526]
exact_synonym: "RPL27" [UniProt:P61353, EntrezGene:6155, HGNC:10328, MIM:607526]
xref_analog: UniProt:P61353
relationship: sequence_of IMR:0010476 ! 60S ribosomal protein L27

[Term]
id: IMR:0001312
name: RL27_MOUSE
exact_synonym: "60S ribosomal protein L27" [UniProt:P61358]
exact_synonym: "ribosomal protein L27" [MGI:98036]
exact_synonym: "Rpl27" [MGI:98036, UniProt:P61358]
xref_analog: UniProt:P61358
relationship: sequence_of IMR:0010476 ! 60S ribosomal protein L27

[Term]
id: IMR:0001313
name: RL30_HUMAN
exact_synonym: "60S ribosomal protein L30" [UniProt:P62888]
exact_synonym: "ribosomal protein L30" [EntrezGene:6156, MIM:180467, HGNC:10333]
exact_synonym: "RPL30" [UniProt:P62888, EntrezGene:6156, MIM:180467, HGNC:10333]
xref_analog: UniProt:P62888
relationship: sequence_of IMR:0010481 ! 60S ribosomal protein L30

[Term]
id: IMR:0001314
name: RL30_MOUSE
exact_synonym: "60S ribosomal protein L30" [UniProt:P62889]
exact_synonym: "ribosomal protein L30" [MGI:98037]
exact_synonym: "Rpl30" [MGI:98037, UniProt:P62889]
xref_analog: UniProt:P62889
relationship: sequence_of IMR:0010481 ! 60S ribosomal protein L30

[Term]
id: IMR:0001315
name: RL31_HUMAN
exact_synonym: "60S ribosomal protein L31" [UniProt:P62899]
exact_synonym: "MGC88191" [EntrezGene:6160]
exact_synonym: "ribosomal protein L31" [HGNC:10334, EntrezGene:6160]
exact_synonym: "RPL31" [HGNC:10334, UniProt:P62899, EntrezGene:6160]
xref_analog: UniProt:P62899
relationship: sequence_of IMR:0010482 ! 60S ribosomal protein L31

[Term]
id: IMR:0001316
name: RL31_MOUSE
exact_synonym: "60S ribosomal protein L31" [UniProt:P62900]
exact_synonym: "ribosomal protein L31" [MGI:2149632]
exact_synonym: "Rpl31" [UniProt:P62900, MGI:2149632]
xref_analog: UniProt:P62900
relationship: sequence_of IMR:0010482 ! 60S ribosomal protein L31

[Term]
id: IMR:0001317
name: RL32_HUMAN
exact_synonym: "60S ribosomal protein L32" [UniProt:P62910]
exact_synonym: "ribosomal protein L32" [HGNC:10336, EntrezGene:6161]
exact_synonym: "RPL32" [HGNC:10336, UniProt:P62910, EntrezGene:6161]
xref_analog: UniProt:P62910
relationship: sequence_of IMR:0010483 ! 60S ribosomal protein L32

[Term]
id: IMR:0001318
name: RL32_MOUSE
exact_synonym: "60S ribosomal protein L32" [UniProt:P62911]
exact_synonym: "ribosomal protein L32" [MGI:98038]
exact_synonym: "Rpl32" [UniProt:P62911, MGI:98038]
exact_synonym: "rpL32-3A" [MGI:98038]
xref_analog: UniProt:P62911
relationship: sequence_of IMR:0010483 ! 60S ribosomal protein L32

[Term]
id: IMR:0001319
name: RL37_HUMAN
exact_synonym: "60S ribosomal protein L37" [UniProt:P61927]
exact_synonym: "DKFZp686G1699" [EntrezGene:6167]
exact_synonym: "G1.16" [UniProt:P61927]
exact_synonym: "MGC99572" [EntrezGene:6167]
exact_synonym: "ribosomal protein L37" [EntrezGene:6167, MIM:604181, HGNC:10347]
exact_synonym: "RPL37" [EntrezGene:6167, MIM:604181, HGNC:10347, UniProt:P61927]
xref_analog: UniProt:P61927
relationship: sequence_of IMR:0010487 ! 60S ribosomal protein L37

[Term]
id: IMR:0001320
name: RL37_MOUSE
exact_synonym: "60S ribosomal protein L37" [UniProt:Q9D823]
exact_synonym: "ribosomal protein L37" [MGI:1914531]
exact_synonym: "Rpl37" [MGI:1914531, UniProt:Q9D823]
xref_analog: UniProt:Q9D823
relationship: sequence_of IMR:0010487 ! 60S ribosomal protein L37

[Term]
id: IMR:0001321
name: RL37A_HUMAN
exact_synonym: "60S ribosomal protein L37a" [UniProt:P61513]
exact_synonym: "MGC74786" [EntrezGene:6168]
exact_synonym: "ribosomal protein L37a" [HGNC:10348, MIM:613314, EntrezGene:6168]
exact_synonym: "RPL37A" [HGNC:10348, MIM:613314, EntrezGene:6168, UniProt:P61513]
xref_analog: UniProt:P61513
relationship: sequence_of IMR:0010449 ! 60S ribosomal protein L37a

[Term]
id: IMR:0001322
name: RL37A_MOUSE
exact_synonym: "60S ribosomal protein L37a" [UniProt:P61514]
exact_synonym: "ribosomal protein L37a" [MGI:98068]
exact_synonym: "Rpl37a" [UniProt:P61514, MGI:98068]
xref_analog: UniProt:P61514
relationship: sequence_of IMR:0010449 ! 60S ribosomal protein L37a

[Term]
id: IMR:0001323
name: RL38_HUMAN
exact_synonym: "60S ribosomal protein L38" [UniProt:P63173]
exact_synonym: "ribosomal protein L38" [HGNC:10349, EntrezGene:6169, MIM:604182]
exact_synonym: "RPL38" [UniProt:P63173, HGNC:10349, EntrezGene:6169, MIM:604182]
xref_analog: UniProt:P63173
relationship: sequence_of IMR:0010488 ! 60S ribosomal protein L38

[Term]
id: IMR:0001324
name: RL38_MOUSE
exact_synonym: "60S ribosomal protein L38" [UniProt:Q9JJI8]
exact_synonym: "ribosomal protein L38" [MGI:1914921]
exact_synonym: "Rpl38" [UniProt:Q9JJI8, MGI:1914921]
exact_synonym: "Ts" [MGI:1914921]
xref_analog: UniProt:Q9JJI8
relationship: sequence_of IMR:0010488 ! 60S ribosomal protein L38

[Term]
id: IMR:0001325
name: RL39_HUMAN
exact_synonym: "60S ribosomal protein L39" [UniProt:P62891]
exact_synonym: "ribosomal protein L39" [HGNC:10350, EntrezGene:6170, MIM:601904]
exact_synonym: "RPL39" [HGNC:10350, EntrezGene:6170, MIM:601904, UniProt:P62891]
xref_analog: UniProt:P62891
relationship: sequence_of IMR:0010489 ! 60S ribosomal protein L39

[Term]
id: IMR:0001326
name: RL39_MOUSE
exact_synonym: "60S ribosomal protein L39" [UniProt:P62892]
exact_synonym: "ribosomal protein L39" [MGI:1914498]
exact_synonym: "Rpl39" [MGI:1914498, UniProt:P62892]
xref_analog: UniProt:P62892
relationship: sequence_of IMR:0010489 ! 60S ribosomal protein L39

[Term]
id: IMR:0001327
name: RL40_HUMAN
exact_synonym: "60S ribosomal protein L40" [UniProt:P62987]
exact_synonym: "CEP52" [EntrezGene:7311, MIM:191321, UniProt:P62987, HGNC:12458]
exact_synonym: "HUBCEP52" [EntrezGene:7311, MIM:191321, HGNC:12458]
exact_synonym: "HUMAN UBIQUITIN CARBOXYL EXTENSION PROTEIN, 52-RESIDUE" [MIM:191321]
exact_synonym: "MGC126879" [EntrezGene:7311, HGNC:12458]
exact_synonym: "MGC126881" [EntrezGene:7311, HGNC:12458]
exact_synonym: "MGC57125" [EntrezGene:7311, HGNC:12458]
exact_synonym: "RIBOSOMAL PROTEIN L40" [MIM:191321]
exact_synonym: "RPL40" [EntrezGene:7311, MIM:191321, HGNC:12458]
exact_synonym: "UBA52" [EntrezGene:7311, MIM:191321, UniProt:P62987, HGNC:12458]
exact_synonym: "UBCEP, 52-AMINO ACID" [MIM:191321]
exact_synonym: "UBCEP2" [UniProt:P62987]
exact_synonym: "Ubiquitin" [UniProt:P62987]
exact_synonym: "Ubiquitin A-52 residue ribosomal protein fusion product 1" [UniProt:P62987]
exact_synonym: "ubiquitin A-52 residue ribosomal protein fusion product 1" [EntrezGene:7311, HGNC:12458]
exact_synonym: "UBIQUITIN A-52-RESIDUE RIBOSOMAL PROTEIN FUSION PRODUCT" [MIM:191321]
exact_synonym: "Ubiquitin-60S ribosomal protein L40" [UniProt:P62987]
xref_analog: UniProt:P62987
relationship: sequence_of IMR:0010492 ! 60S ribosomal protein L40

[Term]
id: IMR:0001328
name: RL40_MOUSE
exact_synonym: "60S ribosomal protein L40" [UniProt:P62984]
exact_synonym: "CEP52" [UniProt:P62984]
exact_synonym: "D8Ertd21e" [MGI:98887]
exact_synonym: "Uba52" [UniProt:P62984, MGI:98887]
exact_synonym: "Ubcep2" [UniProt:P62984]
exact_synonym: "Ubiquitin" [UniProt:P62984]
exact_synonym: "Ubiquitin A-52 residue ribosomal protein fusion product 1" [UniProt:P62984]
exact_synonym: "ubiquitin A-52 residue ribosomal protein fusion product 1" [MGI:98887]
exact_synonym: "Ubiquitin-60S ribosomal protein L40" [UniProt:P62984]
xref_analog: UniProt:P62984
relationship: sequence_of IMR:0010492 ! 60S ribosomal protein L40

[Term]
id: IMR:0001329
name: RL41_HUMAN
exact_synonym: "60S ribosomal protein L41" [UniProt:P62945]
exact_synonym: "HG12" [MIM:613315, UniProt:P62945]
exact_synonym: "ribosomal protein L41" [MIM:613315, HGNC:10354, EntrezGene:6171]
exact_synonym: "RPL41" [MIM:613315, HGNC:10354, UniProt:P62945, EntrezGene:6171]
xref_analog: UniProt:P62945
relationship: sequence_of IMR:0010493 ! 60S ribosomal protein L41

[Term]
id: IMR:0001330
name: RL41_MOUSE
exact_synonym: "60S ribosomal protein L41" [UniProt:P62947]
exact_synonym: "ribosomal protein L41" [MGI:1915195]
exact_synonym: "Rpl41" [MGI:1915195, UniProt:P62947]
xref_analog: UniProt:P62947
relationship: sequence_of IMR:0010493 ! 60S ribosomal protein L41

[Term]
id: IMR:0001331
name: RL36A_HUMAN
exact_synonym: "60S ribosomal protein L36a" [UniProt:P83881]
exact_synonym: "60S ribosomal protein L44" [UniProt:P83881]
exact_synonym: "Cell growth-inhibiting gene 15 protein" [UniProt:P83881]
exact_synonym: "Cell migration-inducing gene 6 protein" [UniProt:P83881]
exact_synonym: "L44L" [EntrezGene:6173]
exact_synonym: "MGC72020" [EntrezGene:6173]
exact_synonym: "MIG6" [EntrezGene:6173]
exact_synonym: "ribosomal protein L36a" [HGNC:10359, EntrezGene:6173]
exact_synonym: "RPL36A" [UniProt:P83881, HGNC:10359, EntrezGene:6173]
exact_synonym: "RPL44" [UniProt:P83881, EntrezGene:6173]
xref_analog: UniProt:P83881
relationship: sequence_of IMR:0010494 ! 60S ribosomal protein L36a

[Term]
id: IMR:0001332
name: RL36A_MOUSE
exact_synonym: "60S ribosomal protein L36a" [UniProt:P83882]
exact_synonym: "60S ribosomal protein L44" [UniProt:P83882]
exact_synonym: "L44L" [MGI:1201789]
exact_synonym: "ribosomal protein L36A" [MGI:1201789]
exact_synonym: "Rpl36a" [UniProt:P83882, MGI:1201789]
exact_synonym: "Rpl44" [UniProt:P83882, MGI:1201789]
xref_analog: UniProt:P83882
relationship: sequence_of IMR:0010494 ! 60S ribosomal protein L36a

[Term]
id: IMR:0001333
name: RL7A_HUMAN
exact_synonym: "60S ribosomal protein L7a" [UniProt:P62424]
exact_synonym: "PLA-X polypeptide" [UniProt:P62424]
exact_synonym: "ribosomal protein L7a" [HGNC:10364, MIM:185640, EntrezGene:6130]
exact_synonym: "RPL7A" [HGNC:10364, UniProt:P62424, MIM:185640, EntrezGene:6130]
exact_synonym: "SURF-3" [UniProt:P62424]
exact_synonym: "SURF3" [HGNC:10364, UniProt:P62424, MIM:185640, EntrezGene:6130]
exact_synonym: "SURFEIT 3" [MIM:185640]
exact_synonym: "Surfeit locus protein 3" [UniProt:P62424]
exact_synonym: "TRUP" [HGNC:10364, EntrezGene:6130]
xref_analog: UniProt:P62424
relationship: sequence_of IMR:0010498 ! 60S ribosomal protein L7a

[Term]
id: IMR:0001334
name: RL7A_MOUSE
exact_synonym: "60S ribosomal protein L7a" [UniProt:P12970]
exact_synonym: "ribosomal protein L7A" [MGI:1353472]
exact_synonym: "Rpl7a" [UniProt:P12970, MGI:1353472]
exact_synonym: "Surf-3" [UniProt:P12970, MGI:1353472]
exact_synonym: "Surf3" [UniProt:P12970]
exact_synonym: "surfeit 3" [MGI:1353472]
exact_synonym: "Surfeit locus protein 3" [UniProt:P12970]
xref_analog: UniProt:P12970
relationship: sequence_of IMR:0010498 ! 60S ribosomal protein L7a

[Term]
id: IMR:0001335
name: RUXE_HUMAN
exact_synonym: "B-raf" [EntrezGene:6635]
exact_synonym: "E PROTEIN OF SMALL NUCLEAR RIBONUCLEOPROTEIN COMPLEXES" [MIM:128260]
exact_synonym: "Sm protein E" [UniProt:P62304]
exact_synonym: "Sm-E" [EntrezGene:6635, HGNC:11161, UniProt:P62304]
exact_synonym: "Small nuclear ribonucleoprotein E" [UniProt:P62304]
exact_synonym: "small nuclear ribonucleoprotein polypeptide E" [EntrezGene:6635, MIM:128260, HGNC:11161]
exact_synonym: "SmE" [UniProt:P62304]
exact_synonym: "SME" [EntrezGene:6635]
exact_synonym: "snRNP-E" [UniProt:P62304]
exact_synonym: "SNRPE" [EntrezGene:6635, MIM:128260, HGNC:11161, UniProt:P62304]
xref_analog: UniProt:P62304
relationship: sequence_of IMR:0010572 ! Small nuclear ribonucleoprotein E

[Term]
id: IMR:0001336
name: RUXF_HUMAN
exact_synonym: "PBSCF" [UniProt:P62306]
exact_synonym: "Sm protein F" [UniProt:P62306]
exact_synonym: "Sm-F" [EntrezGene:6636, HGNC:11162, UniProt:P62306]
exact_synonym: "Small nuclear ribonucleoprotein F" [UniProt:P62306]
exact_synonym: "small nuclear ribonucleoprotein polypeptide F" [EntrezGene:6636, HGNC:11162, MIM:603541]
exact_synonym: "SmF" [UniProt:P62306]
exact_synonym: "SMF" [EntrezGene:6636]
exact_synonym: "snRNP-F" [UniProt:P62306]
exact_synonym: "SNRPF" [EntrezGene:6636, HGNC:11162, MIM:603541, UniProt:P62306]
xref_analog: UniProt:P62306
relationship: sequence_of IMR:0010573 ! Small nuclear ribonucleoprotein F

[Term]
id: IMR:0001337
name: RUXG_HUMAN
exact_synonym: "MGC117317" [EntrezGene:6637]
exact_synonym: "PBSCG" [UniProt:P62308]
exact_synonym: "Sm protein G" [UniProt:P62308]
exact_synonym: "Sm-G" [UniProt:P62308, HGNC:11163, EntrezGene:6637]
exact_synonym: "Small nuclear ribonucleoprotein G" [UniProt:P62308]
exact_synonym: "small nuclear ribonucleoprotein polypeptide G" [HGNC:11163, EntrezGene:6637, MIM:603542]
exact_synonym: "SmG" [UniProt:P62308]
exact_synonym: "SMG" [EntrezGene:6637]
exact_synonym: "snRNP-G" [UniProt:P62308]
exact_synonym: "SNRPG" [UniProt:P62308, HGNC:11163, EntrezGene:6637, MIM:603542]
xref_analog: UniProt:P62308
relationship: sequence_of IMR:0010574 ! Small nuclear ribonucleoprotein G

[Term]
id: IMR:0001338
name: HNRPK_HUMAN
exact_synonym: "CSBP" [EntrezGene:3190, HGNC:5044]
exact_synonym: "FLJ41122" [EntrezGene:3190]
exact_synonym: "Heterogeneous nuclear ribonucleoprotein K" [MIM:600712, UniProt:P61978]
exact_synonym: "heterogeneous nuclear ribonucleoprotein K" [EntrezGene:3190, HGNC:5044]
exact_synonym: "hnRNP K" [UniProt:P61978]
exact_synonym: "HNRNPK" [MIM:600712, EntrezGene:3190, HGNC:5044, UniProt:P61978]
exact_synonym: "HNRPK" [MIM:600712, EntrezGene:3190, UniProt:P61978]
exact_synonym: "Transformation up-regulated nuclear protein" [UniProt:P61978]
exact_synonym: "TUNP" [EntrezGene:3190, HGNC:5044, UniProt:P61978]
xref_analog: UniProt:P61978
relationship: sequence_of IMR:0010515 ! Heterogeneous nuclear ribonucleoprotein K

[Term]
id: IMR:0001339
name: HNRPK_MOUSE
exact_synonym: "Heterogeneous nuclear ribonucleoprotein K" [UniProt:P61979]
exact_synonym: "heterogeneous nuclear ribonucleoprotein K" [MGI:99894]
exact_synonym: "hnRNP K" [UniProt:P61979]
exact_synonym: "Hnrnpk" [UniProt:P61979, MGI:99894]
exact_synonym: "hnRNPK" [MGI:99894]
exact_synonym: "Hnrpk" [UniProt:P61979, MGI:99894]
exact_synonym: "KBBP" [MGI:99894]
xref_analog: UniProt:P61979
relationship: sequence_of IMR:0010515 ! Heterogeneous nuclear ribonucleoprotein K

[Term]
id: IMR:0001340
name: CALM_HUMAN
exact_synonym: "CALM" [UniProt:P62158]
exact_synonym: "CALM1" [EntrezGene:805, MIM:114180, HGNC:1442, EntrezGene:801]
exact_synonym: "CALM2" [EntrezGene:805, MIM:114182, EntrezGene:801, HGNC:1445]
exact_synonym: "CALM3" [EntrezGene:805, EntrezGene:801, HGNC:1449, MIM:114183, UniProt:P62158]
exact_synonym: "CALML2" [EntrezGene:801]
exact_synonym: "Calmodulin" [UniProt:P62158]
exact_synonym: "CALMODULIN 1" [MIM:114180]
exact_synonym: "calmodulin 1 (phosphorylase kinase, delta)" [HGNC:1442, EntrezGene:801]
exact_synonym: "CALMODULIN 2" [MIM:114182]
exact_synonym: "calmodulin 2 (phosphorylase kinase, delta)" [EntrezGene:805, HGNC:1445]
exact_synonym: "CALMODULIN 3" [MIM:114183]
exact_synonym: "calmodulin 3 (phosphorylase kinase, delta)" [HGNC:1449]
exact_synonym: "CaM" [UniProt:P62158]
exact_synonym: "CAM" [UniProt:P62158]
exact_synonym: "CAM1 CAM2" [UniProt:P62158]
exact_synonym: "CAM3" [UniProt:P62158]
exact_synonym: "CAMB CALML2" [UniProt:P62158]
exact_synonym: "CAMC" [UniProt:P62158]
exact_synonym: "CAMI" [HGNC:1442, EntrezGene:801]
exact_synonym: "CAMII" [EntrezGene:805, HGNC:1445]
exact_synonym: "CAMIII" [UniProt:P62158]
exact_synonym: "DD132" [HGNC:1442, EntrezGene:801]
exact_synonym: "FLJ99410" [EntrezGene:805]
exact_synonym: "PHKD" [EntrezGene:805, MIM:114180, HGNC:1442, EntrezGene:801, HGNC:1445, HGNC:1449]
exact_synonym: "PHKD2" [EntrezGene:805, MIM:114182]
exact_synonym: "PHKD3" [MIM:114183]
exact_synonym: "PHOSPHORYLASE KINASE, DELTA SUBUNIT" [MIM:114180]
xref_analog: UniProt:P62158
relationship: sequence_of IMR:0000457 ! calmodulin

[Term]
id: IMR:0001341
name: CALM_MOUSE
exact_synonym: "Calm" [UniProt:P62204]
exact_synonym: "Calm1" [MGI:88251]
exact_synonym: "Calm2" [MGI:103250]
exact_synonym: "Calm3" [UniProt:P62204, MGI:103249]
exact_synonym: "Calmodulin" [UniProt:P62204]
exact_synonym: "calmodulin 1" [MGI:88251]
exact_synonym: "calmodulin 2" [MGI:103250]
exact_synonym: "calmodulin 3" [MGI:103249]
exact_synonym: "CaM" [UniProt:P62204]
exact_synonym: "Cam" [UniProt:P62204]
exact_synonym: "Cam1 Cam2" [UniProt:P62204]
exact_synonym: "Camb Cam3" [UniProt:P62204]
exact_synonym: "Camc" [UniProt:P62204]
xref_analog: UniProt:P62204
relationship: sequence_of IMR:0000457 ! calmodulin

[Term]
id: IMR:0001342
name: CALM_RAT
exact_synonym: "Calm" [UniProt:P62161]
exact_synonym: "Calm1" [RGD:2257]
exact_synonym: "Calm2" [RGD:2258]
exact_synonym: "Calm3" [RGD:2259, UniProt:P62161]
exact_synonym: "Calmodulin" [UniProt:P62161]
exact_synonym: "calmodulin 1" [RGD:2257]
exact_synonym: "calmodulin 2" [RGD:2258]
exact_synonym: "calmodulin 3" [RGD:2259]
exact_synonym: "CaM" [UniProt:P62161]
exact_synonym: "Cam" [UniProt:P62161]
exact_synonym: "Cam1 Cam2" [UniProt:P62161]
exact_synonym: "Camb Cam3" [UniProt:P62161]
exact_synonym: "Camc" [UniProt:P62161]
xref_analog: UniProt:P62161
relationship: sequence_of IMR:0000457 ! calmodulin

[Term]
id: IMR:0001343
name: SRSF3_HUMAN
exact_synonym: "Pre-mRNA-splicing factor SRP20" [UniProt:P84103]
exact_synonym: "Serine/arginine-rich splicing factor 3" [UniProt:P84103]
exact_synonym: "serine/arginine-rich splicing factor 3" [HGNC:10785, EntrezGene:6428]
exact_synonym: "SFRS3" [MIM:603364, UniProt:P84103, EntrezGene:6428]
exact_synonym: "Splicing factor, arginine/serine-rich 3" [UniProt:P84103]
exact_synonym: "SPLICING FACTOR, ARGININE/SERINE-RICH, 20-KD" [MIM:603364]
exact_synonym: "SPLICING FACTOR, ARGININE/SERINE-RICH, 3" [MIM:603364]
exact_synonym: "SRP20" [MIM:603364, UniProt:P84103]
exact_synonym: "SRp20" [HGNC:10785, EntrezGene:6428]
exact_synonym: "SRSF3" [UniProt:P84103, HGNC:10785, EntrezGene:6428]
xref_analog: UniProt:P84103
relationship: sequence_of IMR:0010589 ! Splicing factor, arginine/serine-rich 3

[Term]
id: IMR:0001344
name: B2L11_HUMAN
exact_synonym: "BAM" [EntrezGene:10018]
exact_synonym: "Bcl-2-like protein 11" [UniProt:O43521]
exact_synonym: "Bcl2-interacting mediator of cell death" [UniProt:O43521]
exact_synonym: "BCL2-INTERACTING PROTEIN BIM" [MIM:603827]
exact_synonym: "Bcl2-L-11" [UniProt:O43521]
exact_synonym: "BCL2-LIKE 11" [MIM:603827]
exact_synonym: "BCL2-like 11 (apoptosis facilitator)" [EntrezGene:10018, HGNC:994]
exact_synonym: "BCL2L11" [UniProt:O43521, EntrezGene:10018, HGNC:994, MIM:603827]
exact_synonym: "BIM" [UniProt:O43521, EntrezGene:10018, HGNC:994, MIM:603827]
exact_synonym: "BIM-alpha6" [EntrezGene:10018]
exact_synonym: "BIM-beta6" [EntrezGene:10018]
exact_synonym: "BIM-beta7" [EntrezGene:10018]
exact_synonym: "BimEL" [EntrezGene:10018, HGNC:994]
exact_synonym: "BimL" [EntrezGene:10018, HGNC:994]
exact_synonym: "BOD" [EntrezGene:10018, HGNC:994]
xref_analog: UniProt:O43521
relationship: sequence_of IMR:0100291 ! Bim

[Term]
id: IMR:0001345
name: SMD1_HUMAN
exact_synonym: "HsT2456" [EntrezGene:6632, HGNC:11158]
exact_synonym: "Sm-D autoantigen" [UniProt:P62314]
exact_synonym: "Sm-D1" [EntrezGene:6632, HGNC:11158, UniProt:P62314]
exact_synonym: "small nuclear ribonucleoprotein D1 polypeptide 16kDa" [EntrezGene:6632, HGNC:11158]
exact_synonym: "SMALL NUCLEAR RIBONUCLEOPROTEIN POLYPEPTIDE D1" [MIM:601063]
exact_synonym: "Small nuclear ribonucleoprotein Sm D1" [UniProt:P62314]
exact_synonym: "SMD1" [EntrezGene:6632]
exact_synonym: "snRNP core protein D1" [UniProt:P62314]
exact_synonym: "SNRPD" [EntrezGene:6632]
exact_synonym: "SNRPD1" [EntrezGene:6632, MIM:601063, HGNC:11158, UniProt:P62314]
xref_analog: UniProt:P62314
relationship: sequence_of IMR:0010599 ! Small nuclear ribonucleoprotein Sm D1

[Term]
id: IMR:0001346
name: SMD2_HUMAN
exact_synonym: "Sm-D2" [HGNC:11159, EntrezGene:6633, UniProt:P62316]
exact_synonym: "small nuclear ribonucleoprotein D2 polypeptide 16.5kDa" [HGNC:11159, EntrezGene:6633]
exact_synonym: "SMALL NUCLEAR RIBONUCLEOPROTEIN POLYPEPTIDE D2" [MIM:601061]
exact_synonym: "Small nuclear ribonucleoprotein Sm D2" [UniProt:P62316]
exact_synonym: "SMD2" [EntrezGene:6633]
exact_synonym: "snRNP core protein D2" [UniProt:P62316]
exact_synonym: "SNRPD1" [EntrezGene:6633, UniProt:P62316]
exact_synonym: "SNRPD2" [HGNC:11159, EntrezGene:6633, MIM:601061, UniProt:P62316]
xref_analog: UniProt:P62316
relationship: sequence_of IMR:0010600 ! Small nuclear ribonucleoprotein Sm D2

[Term]
id: IMR:0001347
name: SMD3_HUMAN
exact_synonym: "Sm-D3" [EntrezGene:6634, UniProt:P62318, HGNC:11160]
exact_synonym: "small nuclear ribonucleoprotein D3 polypeptide 18kDa" [EntrezGene:6634, HGNC:11160]
exact_synonym: "SMALL NUCLEAR RIBONUCLEOPROTEIN POLYPEPTIDE D3" [MIM:601062]
exact_synonym: "Small nuclear ribonucleoprotein Sm D3" [UniProt:P62318]
exact_synonym: "SMD3" [EntrezGene:6634, HGNC:11160]
exact_synonym: "snRNP core protein D3" [UniProt:P62318]
exact_synonym: "SNRPD3" [EntrezGene:6634, UniProt:P62318, MIM:601062, HGNC:11160]
xref_analog: UniProt:P62318
relationship: sequence_of IMR:0010601 ! Small nuclear ribonucleoprotein Sm D3

[Term]
id: IMR:0001348
name: phosphatidylinositol polyphosphate
exact_synonym: "polyphosphoinositide" []
is_a: IMR:0001650 ! inositol phospholipid

[Term]
id: IMR:0001349
name: nucleotide
def: "A nucleotide consists of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Nucleotides can carry chemical energy (e.g. ATP), form coenzymes (e.g. CoA), be used as specific signaling molecules (e.g. cAMP) in the cell. Nucleotides are the subunits of the nucleic acids. " [ISBN:0815340729]
exact_synonym: "nucleoside phosphate" []
xref_analog: CHEBI:25608
is_a: IMR:0000947 ! chemical
is_a: IMR:0001698 ! glycoside

[Term]
id: IMR:0001350
name: PI(4,5)P2
alt_id: IMR:0200477
def: "PI(4,5)P2 is cleaved by phospholipase C-beta or gamma to generate IP3 and diacylglycerol." [ISBN:0815340729]
exact_synonym: "1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate" []
exact_synonym: "1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate" []
exact_synonym: "Phosphatidyl-myo-inositol 4,5-bisphosphate" []
exact_synonym: "phosphatidylinositol bisphosphate" []
exact_synonym: "phosphatidylinositol diphosphate" []
exact_synonym: "Phosphatidylinositol-4,5-bisphosphate" []
exact_synonym: "PIP2" []
xref_analog: KEGG:C04637
is_a: IMR:0001348 ! phosphatidylinositol polyphosphate

[Term]
id: IMR:0001351
name: ATP
alt_id: IMR:0100127
alt_id: IMR:0200394
exact_synonym: "adenosine 5'-triphosphate" []
exact_synonym: "adenosine triphosphate" []
xref_analog: KEGG:C00002
is_a: IMR:0000967 ! chemical neurotransmitter
is_a: IMR:0001349 ! nucleotide

[Term]
id: IMR:0001352
name: PI(3,4,5)P3
alt_id: IMR:0200396
def: "PI(3,4,5)P2 is generated by phosphorylation of PI(4,5)P at the 3 position of the inositol ring catalyzed by PI3-kinase. NOT cleaved by phospholipase C." [ISBN:0815340729]
exact_synonym: "1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate" []
exact_synonym: "Phosphatidylinositol-3,4,5-trisphosphate " []
exact_synonym: "PIP3" []
xref_analog: KEGG:C05981
is_a: IMR:0001348 ! phosphatidylinositol polyphosphate

[Term]
id: IMR:0001353
name: PI(3,4)P2
def: "PI(3,4)P2 is generated by phosphorylation of PI(4)P at the 3 position of the inositol ring catalyzed by PI3-kinase. NOT cleaved by phospholipase C." [ISBN:0815340729]
exact_synonym: "1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate " []
xref_analog: KEGG:C11554
is_a: IMR:0001348 ! phosphatidylinositol polyphosphate

[Term]
id: IMR:0001354
name: GTP
alt_id: IMR:0200086
exact_synonym: "guanosine 5'-triphosphate" []
xref_analog: KEGG:C00044
is_a: IMR:0001349 ! nucleotide

[Term]
id: IMR:0001355
name: cyclic nucleotide
xref_analog: CHEBI:23447
is_a: IMR:0001349 ! nucleotide

[Term]
id: IMR:0001356
name: phospholipid
xref_analog: CHEBI:26063
is_a: IMR:0001362 ! lipid

[Term]
id: IMR:0001357
name: GDP
alt_id: IMR:0200191
xref_analog: KEGG:C00035
is_a: IMR:0001349 ! nucleotide

[Term]
id: IMR:0001358
name: phosphatidylserine
alt_id: IMR:0200250
exact_synonym: "O-Phosphatidyl-L-serine" []
xref_analog: CHEBI:18303
xref_analog: KEGG:C02737
is_a: IMR:0001384 ! glycerophospholipid

[Term]
id: IMR:0001359
name: sphingolipid
xref_analog: CHEBI:26739
is_a: IMR:0001362 ! lipid

[Term]
id: IMR:0001360
name: ADP
alt_id: IMR:0200375
xref_analog: KEGG:C00008
is_a: IMR:0001349 ! nucleotide

[Term]
id: IMR:0001361
name: sphingomyelin
xref_analog: CHEBI:17636
xref_analog: KEGG:C00550
is_a: IMR:0001383 ! sphingophospholipid

[Term]
id: IMR:0001362
name: lipid
def: "Organic molecule that is insoluble in water but tends to dissolve in nonpolar organic solvent." [ISBN:0815340729]
xref_analog: CHEBI:25054
is_a: IMR:0000947 ! chemical

[Term]
id: IMR:0001363
name: Gli1
is_a: IMR:0001372 ! Ci/Gli

[Term]
id: IMR:0001364
name: GLI1_HUMAN
exact_synonym: "GLI" [MIM:165220, EntrezGene:2735, UniProt:P08151]
exact_synonym: "GLI family zinc finger 1" [HGNC:4317, EntrezGene:2735]
exact_synonym: "GLI1" [HGNC:4317, MIM:165220, EntrezGene:2735, UniProt:P08151]
exact_synonym: "Glioma-associated oncogene" [UniProt:P08151]
exact_synonym: "GLIOMA-ASSOCIATED ONCOGENE HOMOLOG" [MIM:165220]
exact_synonym: "Oncogene GLI" [MIM:165220, UniProt:P08151]
exact_synonym: "Zinc finger protein GLI1" [UniProt:P08151]
xref_analog: UniProt:P08151
relationship: sequence_of IMR:0001363 ! Gli1

[Term]
id: IMR:0001365
name: GLI1_MOUSE
exact_synonym: "Gli" [UniProt:P47806]
exact_synonym: "GLI-Kruppel family member GLI1" [MGI:95727]
exact_synonym: "Gli1" [MGI:95727, UniProt:P47806]
exact_synonym: "Glioma-associated oncogene homolog" [UniProt:P47806]
exact_synonym: "Zfp-5" [MGI:95727]
exact_synonym: "Zfp5" [MGI:95727]
exact_synonym: "Zinc finger protein GLI1" [UniProt:P47806]
xref_analog: UniProt:P47806
relationship: sequence_of IMR:0001363 ! Gli1

[Term]
id: IMR:0001366
name: Gli2
is_a: IMR:0001372 ! Ci/Gli

[Term]
id: IMR:0001367
name: GLI2_HUMAN
exact_synonym: "GLI family zinc finger 2" [HGNC:4318, EntrezGene:2736]
exact_synonym: "GLI-KRUPPEL FAMILY MEMBER 2" [MIM:165230]
exact_synonym: "GLI2" [UniProt:P10070, HGNC:4318, EntrezGene:2736, MIM:165230]
exact_synonym: "HPE9" [HGNC:4318, EntrezGene:2736]
exact_synonym: "ONCOGENE GLI2" [MIM:165230]
exact_synonym: "Tax helper protein" [UniProt:P10070]
exact_synonym: "THP" [UniProt:P10070]
exact_synonym: "THP1" [HGNC:4318, EntrezGene:2736]
exact_synonym: "THP2" [HGNC:4318, EntrezGene:2736]
exact_synonym: "Zinc finger protein GLI2" [UniProt:P10070]
xref_analog: UniProt:P10070
relationship: sequence_of IMR:0001366 ! Gli2

[Term]
id: IMR:0001368
name: Gli3
is_a: IMR:0001372 ! Ci/Gli

[Term]
id: IMR:0001369
name: GLI3_HUMAN
exact_synonym: "ACLS" [HGNC:4319, EntrezGene:2737]
exact_synonym: "GCPS" [EntrezGene:2737]
exact_synonym: "GLI family zinc finger 3" [HGNC:4319, EntrezGene:2737]
exact_synonym: "GLI-KRUPPEL FAMILY MEMBER 3" [MIM:165240]
exact_synonym: "GLI3" [HGNC:4319, UniProt:P10071, EntrezGene:2737, MIM:165240]
exact_synonym: "ONCOGENE GLI3" [MIM:165240]
exact_synonym: "PAP-A" [HGNC:4319, EntrezGene:2737]
exact_synonym: "PAPA" [HGNC:4319, EntrezGene:2737]
exact_synonym: "PAPA1" [HGNC:4319, EntrezGene:2737]
exact_synonym: "PAPB" [HGNC:4319, EntrezGene:2737]
exact_synonym: "PHS" [EntrezGene:2737]
exact_synonym: "PPDIV" [HGNC:4319, EntrezGene:2737]
exact_synonym: "Zinc finger protein GLI3" [UniProt:P10071]
xref_analog: UniProt:P10071
relationship: sequence_of IMR:0001368 ! Gli3

[Term]
id: IMR:0001370
name: GLI3_MOUSE
exact_synonym: "Bph" [MGI:95729]
exact_synonym: "brachyphalangy" [MGI:95729]
exact_synonym: "GLI-Kruppel family member GLI3" [MGI:95729]
exact_synonym: "Gli3" [UniProt:Q61602, MGI:95729]
exact_synonym: "Zinc finger protein GLI3" [UniProt:Q61602]
xref_analog: UniProt:Q61602
relationship: sequence_of IMR:0001368 ! Gli3

[Term]
id: IMR:0001371
name: Gli
comment: This term was made obsolete. To update annotations, consider the term 'IMR0001372:Ci/Gli'.
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0001372
name: Ci/Gli
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0001373
name: Q9GPL5_DROME
exact_synonym: "CG17703" [FlyBase:FBgn0041604]
exact_synonym: "CG32146" [FlyBase:FBgn0041604]
exact_synonym: "CG5031" [FlyBase:FBgn0041604]
exact_synonym: "CT16138" [FlyBase:FBgn0041604]
exact_synonym: "D-glypican B" [FlyBase:FBgn0041604]
exact_synonym: "D-gpcB" [FlyBase:FBgn0041604]
exact_synonym: "Dally-like" [FlyBase:FBgn0041604]
exact_synonym: "dally-like" [FlyBase:FBgn0041604]
exact_synonym: "Dally-like protein" [UniProt:Q9GPL5]
exact_synonym: "dlp" [UniProt:Q9GPL5, FlyBase:FBgn0041604]
exact_synonym: "Dlp" [FlyBase:FBgn0041604]
exact_synonym: "Dly" [FlyBase:FBgn0041604]
exact_synonym: "dly" [FlyBase:FBgn0041604]
xref_analog: UniProt:Q9GPL5
relationship: sequence_of IMR:0002958 ! Dlp/Dally

[Term]
id: IMR:0001374
name: dispatched
is_a: IMR:0000920 ! transporter

[Term]
id: IMR:0001375
name: DISP_DROME
exact_synonym: "anon-WO0146227.1" [FlyBase:FBgn0029088]
exact_synonym: "CG2019" [FlyBase:FBgn0029088]
exact_synonym: "disp" [UniProt:Q9VNJ5, FlyBase:FBgn0029088]
exact_synonym: "dispatched" [FlyBase:FBgn0029088]
exact_synonym: "Protein dispatched" [UniProt:Q9VNJ5]
xref_analog: UniProt:Q9VNJ5
relationship: sequence_of IMR:0001374 ! dispatched

[Term]
id: IMR:0001376
name: DISP1_MOUSE
exact_synonym: "Disp" [UniProt:Q3TDN0]
exact_synonym: "Disp1" [MGI:1916147, UniProt:Q3TDN0]
exact_synonym: "Dispa" [UniProt:Q3TDN0]
exact_synonym: "DispA" [MGI:1916147]
exact_synonym: "dispatched homolog 1 (Drosophila)" [MGI:1916147]
exact_synonym: "Icb" [UniProt:Q3TDN0]
exact_synonym: "Icbins" [UniProt:Q3TDN0]
exact_synonym: "Mdispa" [UniProt:Q3TDN0]
exact_synonym: "Protein dispatched homolog 1" [UniProt:Q3TDN0]
xref_analog: UniProt:Q3TDN0
relationship: sequence_of IMR:0001374 ! dispatched

[Term]
id: IMR:0001377
name: DISP2_MOUSE
exact_synonym: "Disp2" [UniProt:Q8CIP5, MGI:2388733]
exact_synonym: "dispatched homolog 2 (Drosophila)" [MGI:2388733]
exact_synonym: "DispB" [MGI:2388733]
exact_synonym: "Kiaa1742" [UniProt:Q8CIP5]
exact_synonym: "Protein dispatched homolog 2" [UniProt:Q8CIP5]
xref_analog: UniProt:Q8CIP5
relationship: sequence_of IMR:0001374 ! dispatched

[Term]
id: IMR:0001378
name: EXT1_DROME
exact_synonym: "CG10117" [FlyBase:FBgn0020245]
exact_synonym: "DEXT1" [UniProt:Q9V730, FlyBase:FBgn0020245]
exact_synonym: "EC 2.4.1.224" [UniProt:Q9V730]
exact_synonym: "EC 2.4.1.225" [UniProt:Q9V730]
exact_synonym: "Exostosin-1" [UniProt:Q9V730]
exact_synonym: "l(2)00681" [FlyBase:FBgn0020245]
exact_synonym: "l(2)05282" [FlyBase:FBgn0020245]
exact_synonym: "l(2)k00115" [FlyBase:FBgn0020245]
exact_synonym: "l(2)k03617" [FlyBase:FBgn0020245]
exact_synonym: "P1.15" [FlyBase:FBgn0020245]
exact_synonym: "Protein tout-velu" [UniProt:Q9V730]
exact_synonym: "tout velu" [FlyBase:FBgn0020245]
exact_synonym: "tout-velu" [FlyBase:FBgn0020245]
exact_synonym: "ttv" [UniProt:Q9V730, FlyBase:FBgn0020245]
xref_analog: UniProt:Q9V730
relationship: sequence_of IMR:0001392 ! Exostosin-1

[Term]
id: IMR:0001379
name: glycosyltransferase
xref_analog: EC:2.4.-.-
xref_analog: GO:0016757
is_a: IMR:0010050 ! transferase

[Term]
id: IMR:0001380
name: Q9PUI2_XENLA
exact_synonym: "Casein kinase I epsilon" [UniProt:Q9PUI2]
exact_synonym: "CKIe" [UniProt:Q9PUI2]
exact_synonym: "CKIe protein" [UniProt:Q9PUI2]
exact_synonym: "csnk1e" [UniProt:Q9PUI2]
xref_analog: UniProt:Q9PUI2
relationship: sequence_of IMR:0100815 ! CKI-epsilon

[Term]
id: IMR:0001381
name: eicosanoid
is_a: IMR:0001362 ! lipid

[Term]
id: IMR:0001382
name: glycerolipid
is_a: IMR:0001362 ! lipid

[Term]
id: IMR:0001383
name: sphingophospholipid
is_a: IMR:0001356 ! phospholipid
is_a: IMR:0001359 ! sphingolipid

[Term]
id: IMR:0001384
name: glycerophospholipid
is_a: IMR:0001356 ! phospholipid
is_a: IMR:0001382 ! glycerolipid

[Term]
id: IMR:0001385
name: inositol phosphate
exact_synonym: "phosphoinositol" []
is_a: IMR:0000947 ! chemical

[Term]
id: IMR:0001386
name: KAPR2_DROME
exact_synonym: "BcDNA:GM01761" [FlyBase:FBgn0022382]
exact_synonym: "cAMP-dependent protein kinase R2" [FlyBase:FBgn0022382]
exact_synonym: "cAMP-dependent protein kinase type II" [FlyBase:FBgn0022382]
exact_synonym: "cAMP-dependent protein kinase type II regulatory subunit" [UniProt:P81900]
exact_synonym: "CG15862" [FlyBase:FBgn0022382]
exact_synonym: "Cos" [FlyBase:FBgn0022382]
exact_synonym: "Cos-1" [FlyBase:FBgn0022382]
exact_synonym: "cos1" [FlyBase:FBgn0022382]
exact_synonym: "Cos1" [FlyBase:FBgn0022382]
exact_synonym: "Costal" [FlyBase:FBgn0022382]
exact_synonym: "Costal-1" [FlyBase:FBgn0022382]
exact_synonym: "costal-1" [FlyBase:FBgn0022382]
exact_synonym: "Epa" [FlyBase:FBgn0022382]
exact_synonym: "Epaulette" [FlyBase:FBgn0022382]
exact_synonym: "PKA" [FlyBase:FBgn0022382]
exact_synonym: "pkA" [FlyBase:FBgn0022382]
exact_synonym: "PKA RII" [FlyBase:FBgn0022382]
exact_synonym: "Pka-R2" [UniProt:P81900, FlyBase:FBgn0022382]
exact_synonym: "PKa-R2" [FlyBase:FBgn0022382]
exact_synonym: "pka-RII" [UniProt:P81900, FlyBase:FBgn0022382]
exact_synonym: "PKA-RII" [FlyBase:FBgn0022382]
exact_synonym: "Pka-RII" [FlyBase:FBgn0022382]
exact_synonym: "RII" [FlyBase:FBgn0022382]
exact_synonym: "RII[[DR]]" [FlyBase:FBgn0022382]
xref_analog: UniProt:P81900
relationship: sequence_of IMR:0100702 ! PKA regulatory subunit

[Term]
id: IMR:0001387
name: KAPC_DROME
exact_synonym: "6353" [FlyBase:FBgn0000273]
exact_synonym: "C" [FlyBase:FBgn0000273]
exact_synonym: "cAMP-dependent protein kinase 1" [FlyBase:FBgn0000273]
exact_synonym: "cAMP-dependent protein kinase catalytic subunit" [UniProt:P12370]
exact_synonym: "CdkA" [UniProt:P12370, FlyBase:FBgn0000273]
exact_synonym: "CG4379" [FlyBase:FBgn0000273]
exact_synonym: "Cos" [FlyBase:FBgn0000273]
exact_synonym: "Cos-1" [FlyBase:FBgn0000273]
exact_synonym: "cos1" [FlyBase:FBgn0000273]
exact_synonym: "Cos1" [FlyBase:FBgn0000273]
exact_synonym: "Costal" [FlyBase:FBgn0000273]
exact_synonym: "Costal-1" [FlyBase:FBgn0000273]
exact_synonym: "costal-1" [FlyBase:FBgn0000273]
exact_synonym: "DC0" [UniProt:P12370, FlyBase:FBgn0000273]
exact_synonym: "Dc0" [FlyBase:FBgn0000273]
exact_synonym: "Dco" [FlyBase:FBgn0000273]
exact_synonym: "DCO" [FlyBase:FBgn0000273]
exact_synonym: "dcO" [FlyBase:FBgn0000273]
exact_synonym: "dco" [FlyBase:FBgn0000273]
exact_synonym: "Dcpk" [FlyBase:FBgn0000273]
exact_synonym: "dPKA" [FlyBase:FBgn0000273]
exact_synonym: "EC 2.7.11.11" [UniProt:P12370]
exact_synonym: "l(2)01272" [FlyBase:FBgn0000273]
exact_synonym: "l(2)cos[[1]]" [FlyBase:FBgn0000273]
exact_synonym: "l(2)s4402" [FlyBase:FBgn0000273]
exact_synonym: "PKA" [FlyBase:FBgn0000273]
exact_synonym: "pkA" [FlyBase:FBgn0000273]
exact_synonym: "pKA" [FlyBase:FBgn0000273]
exact_synonym: "Pka" [FlyBase:FBgn0000273]
exact_synonym: "pka" [FlyBase:FBgn0000273]
exact_synonym: "PKA C" [UniProt:P12370]
exact_synonym: "PKA Cl" [FlyBase:FBgn0000273]
exact_synonym: "Pka-C" [FlyBase:FBgn0000273]
exact_synonym: "Pka-C1" [UniProt:P12370, FlyBase:FBgn0000273]
exact_synonym: "PKA-C1" [FlyBase:FBgn0000273]
exact_synonym: "pka-C1" [FlyBase:FBgn0000273]
exact_synonym: "pka-c1" [FlyBase:FBgn0000273]
exact_synonym: "PKAc" [FlyBase:FBgn0000273]
exact_synonym: "PKAcA" [FlyBase:FBgn0000273]
exact_synonym: "protein kinase A" [FlyBase:FBgn0000273]
exact_synonym: "Protein Kinase A" [FlyBase:FBgn0000273]
xref_analog: UniProt:P12370
relationship: sequence_of IMR:0100703 ! PKA catalytic subunit

[Term]
id: IMR:0001388
name: KDC1_DROME
exact_synonym: "cAMP-dependent protein kinase 2" [FlyBase:FBgn0000274]
exact_synonym: "cAMP-dependent protein kinase type II" [FlyBase:FBgn0000274]
exact_synonym: "CdkB" [FlyBase:FBgn0000274]
exact_synonym: "CG12066" [FlyBase:FBgn0000274]
exact_synonym: "DC1" [UniProt:P16911, FlyBase:FBgn0000274]
exact_synonym: "DC1a" [FlyBase:FBgn0000274]
exact_synonym: "EC 2.7.11.1" [UniProt:P16911]
exact_synonym: "PKA" [FlyBase:FBgn0000274]
exact_synonym: "PKA C2" [FlyBase:FBgn0000274]
exact_synonym: "Pka-C2" [UniProt:P16911, FlyBase:FBgn0000274]
exact_synonym: "Protein kinase DC1" [UniProt:P16911]
xref_analog: UniProt:P16911
relationship: sequence_of IMR:0100703 ! PKA catalytic subunit

[Term]
id: IMR:0001389
name: KDC2_DROME
def: "DC2 protein has the defining biochemical properties of a PKA catalytic  subunit. DC2 is not an essential gene and is unlikely to be functionally redundant with DC0, which has multiple unique functions during development." [PubMed:8601490]
exact_synonym: "5-23" [FlyBase:FBgn0000489]
exact_synonym: "cAMP-dependent protein kinase 3" [FlyBase:FBgn0000489]
exact_synonym: "CG6117" [FlyBase:FBgn0000489]
exact_synonym: "DC2" [FlyBase:FBgn0000489, UniProt:P16912]
exact_synonym: "Dpck" [FlyBase:FBgn0000489]
exact_synonym: "EC 2.7.11.1" [UniProt:P16912]
exact_synonym: "Pk72A" [FlyBase:FBgn0000489]
exact_synonym: "Pk?5" [FlyBase:FBgn0000489]
exact_synonym: "PKA" [FlyBase:FBgn0000489]
exact_synonym: "PKA C3" [FlyBase:FBgn0000489]
exact_synonym: "Pka-C3" [FlyBase:FBgn0000489, UniProt:P16912]
exact_synonym: "Protein kinase DC2" [UniProt:P16912]
exact_synonym: "Protein-kinase-like-72A" [FlyBase:FBgn0000489]
xref_analog: UniProt:P16912
relationship: sequence_of IMR:0100703 ! PKA catalytic subunit

[Term]
id: IMR:0001390
name: KAPR1_DROME
exact_synonym: "18304" [FlyBase:FBgn0259243]
exact_synonym: "cAMP-dependent protein kinase R1" [FlyBase:FBgn0259243]
exact_synonym: "cAMP-dependent protein kinase type I regulatory subunit" [UniProt:P16905]
exact_synonym: "CdkR" [UniProt:P16905, FlyBase:FBgn0259243]
exact_synonym: "CG18677" [FlyBase:FBgn0259243]
exact_synonym: "CG3263" [FlyBase:FBgn0259243]
exact_synonym: "dPKA-RI" [FlyBase:FBgn0259243]
exact_synonym: "dr[[1]]" [FlyBase:FBgn0259243]
exact_synonym: "DRI" [FlyBase:FBgn0259243]
exact_synonym: "DRI class I to class IV" [UniProt:P16905]
exact_synonym: "PKA" [FlyBase:FBgn0259243]
exact_synonym: "pkA" [FlyBase:FBgn0259243]
exact_synonym: "Pka-R1" [UniProt:P16905, FlyBase:FBgn0259243]
exact_synonym: "pka-R1" [FlyBase:FBgn0259243]
exact_synonym: "PKA-RI" [FlyBase:FBgn0259243]
exact_synonym: "Pka-RI" [FlyBase:FBgn0259243]
exact_synonym: "PKAr" [FlyBase:FBgn0259243]
exact_synonym: "PKC" [FlyBase:FBgn0259243]
exact_synonym: "RI" [FlyBase:FBgn0259243]
xref_analog: UniProt:P16905
relationship: sequence_of IMR:0100702 ! PKA regulatory subunit

[Term]
id: IMR:0001391
name: DCO_DROME
def: "dbt is 75% (719/947) identical at the nucleotide level and 86% (260/301) identical at the amino acid level to the kinase domain of human casein kinase I epsilon, suggesting that DBT is a structural homolog of this enzyme." [PubMed:9674431]
exact_synonym: "0538/13" [FlyBase:FBgn0002413]
exact_synonym: "0915/10" [FlyBase:FBgn0002413]
exact_synonym: "1396/02" [FlyBase:FBgn0002413]
exact_synonym: "1447/01" [FlyBase:FBgn0002413]
exact_synonym: "1460/09" [FlyBase:FBgn0002413]
exact_synonym: "CG2048" [FlyBase:FBgn0002413]
exact_synonym: "ck1epsilon" [FlyBase:FBgn0002413]
exact_synonym: "CK1epsilon" [FlyBase:FBgn0002413]
exact_synonym: "CKIepsilon" [FlyBase:FBgn0002413]
exact_synonym: "dbt" [FlyBase:FBgn0002413, UniProt:O76324]
exact_synonym: "Dbt" [FlyBase:FBgn0002413]
exact_synonym: "DBT" [FlyBase:FBgn0002413]
exact_synonym: "DBT/CK1epsilon" [FlyBase:FBgn0002413]
exact_synonym: "dco" [FlyBase:FBgn0002413, UniProt:O76324]
exact_synonym: "Dco" [FlyBase:FBgn0002413]
exact_synonym: "dco-1" [FlyBase:FBgn0002413]
exact_synonym: "DCO/CKIe" [FlyBase:FBgn0002413]
exact_synonym: "ddbt" [FlyBase:FBgn0002413]
exact_synonym: "discs overgrown" [FlyBase:FBgn0002413]
exact_synonym: "Discs overgrown protein kinase" [UniProt:O76324]
exact_synonym: "Discs overgrown/Double time" [FlyBase:FBgn0002413]
exact_synonym: "Double-time" [FlyBase:FBgn0002413]
exact_synonym: "double-time" [FlyBase:FBgn0002413]
exact_synonym: "Doubletime" [FlyBase:FBgn0002413]
exact_synonym: "doubletime" [FlyBase:FBgn0002413]
exact_synonym: "EC 2.7.11.1" [UniProt:O76324]
exact_synonym: "l(3)dco" [FlyBase:FBgn0002413]
exact_synonym: "l(3)dco-1" [FlyBase:FBgn0002413]
exact_synonym: "l(3)discs overgrown" [FlyBase:FBgn0002413]
exact_synonym: "l(3)discs overgrown-1" [FlyBase:FBgn0002413]
exact_synonym: "l(3)j3B9" [FlyBase:FBgn0002413]
exact_synonym: "l(3)rK215" [FlyBase:FBgn0002413]
exact_synonym: "l(3)S053813" [FlyBase:FBgn0002413]
exact_synonym: "l(3)S144701" [FlyBase:FBgn0002413]
exact_synonym: "Protein double-time" [UniProt:O76324]
xref_analog: UniProt:O76324
relationship: sequence_of IMR:0100815 ! CKI-epsilon

[Term]
id: IMR:0001392
name: Exostosin-1
is_a: IMR:0001396 ! Exostosin

[Term]
id: IMR:0001393
name: EXT1_HUMAN
exact_synonym: "EC 2.4.1.224" [UniProt:Q16394]
exact_synonym: "EC 2.4.1.225" [UniProt:Q16394]
exact_synonym: "exostosin 1" [MIM:608177, EntrezGene:2131, HGNC:3512]
exact_synonym: "Exostosin-1" [UniProt:Q16394]
exact_synonym: "EXT" [MIM:608177, EntrezGene:2131]
exact_synonym: "EXT1" [UniProt:Q16394, MIM:608177, EntrezGene:2131, HGNC:3512]
exact_synonym: "Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase" [UniProt:Q16394]
exact_synonym: "LGCR" [EntrezGene:2131]
exact_synonym: "LGS" [EntrezGene:2131]
exact_synonym: "Multiple exostoses protein 1" [UniProt:Q16394]
exact_synonym: "Putative tumor suppressor protein EXT1" [UniProt:Q16394]
exact_synonym: "TRPS2" [EntrezGene:2131]
exact_synonym: "ttv" [HGNC:3512]
exact_synonym: "TTV" [EntrezGene:2131]
xref_analog: UniProt:Q16394
relationship: sequence_of IMR:0001392 ! Exostosin-1

[Term]
id: IMR:0001394
name: EXT1_MOUSE
exact_synonym: "EC 2.4.1.224" [UniProt:P97464]
exact_synonym: "EC 2.4.1.225" [UniProt:P97464]
exact_synonym: "exostoses (multiple) 1" [MGI:894663]
exact_synonym: "Exostosin-1" [UniProt:P97464]
exact_synonym: "Ext1" [UniProt:P97464, MGI:894663]
exact_synonym: "Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase" [UniProt:P97464]
exact_synonym: "Multiple exostoses protein 1 homolog" [UniProt:P97464]
xref_analog: UniProt:P97464
relationship: sequence_of IMR:0001392 ! Exostosin-1

[Term]
id: IMR:0001395
name: Exostosin-2
is_a: IMR:0001396 ! Exostosin

[Term]
id: IMR:0001396
name: Exostosin
is_a: IMR:0001379 ! glycosyltransferase

[Term]
id: IMR:0001397
name: EXT2_DROME
exact_synonym: "BcDNA:GH02288" [FlyBase:FBgn0029175]
exact_synonym: "CG33038" [FlyBase:FBgn0029175]
exact_synonym: "CG8433" [FlyBase:FBgn0029175]
exact_synonym: "DEXT2" [UniProt:Q9Y169, FlyBase:FBgn0029175]
exact_synonym: "DExt2" [FlyBase:FBgn0029175]
exact_synonym: "EC 2.4.1.224" [UniProt:Q9Y169]
exact_synonym: "EC 2.4.1.225" [UniProt:Q9Y169]
exact_synonym: "Exostosin-2" [UniProt:Q9Y169]
exact_synonym: "Ext2" [UniProt:Q9Y169, FlyBase:FBgn0029175]
exact_synonym: "Protein sister of tout-velu" [UniProt:Q9Y169]
exact_synonym: "sister of tout-velu" [FlyBase:FBgn0029175]
exact_synonym: "sotv" [UniProt:Q9Y169, FlyBase:FBgn0029175]
exact_synonym: "Sotv" [FlyBase:FBgn0029175]
xref_analog: UniProt:Q9Y169
relationship: sequence_of IMR:0001395 ! Exostosin-2

[Term]
id: IMR:0001398
name: EXT2_HUMAN
exact_synonym: "EC 2.4.1.224" [UniProt:Q93063]
exact_synonym: "EC 2.4.1.225" [UniProt:Q93063]
exact_synonym: "exostosin 2" [HGNC:3513, MIM:608210, EntrezGene:2132]
exact_synonym: "Exostosin-2" [UniProt:Q93063]
exact_synonym: "EXT2" [UniProt:Q93063, HGNC:3513, MIM:608210, EntrezGene:2132]
exact_synonym: "Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase" [UniProt:Q93063]
exact_synonym: "Multiple exostoses protein 2" [UniProt:Q93063]
exact_synonym: "Putative tumor suppressor protein EXT2" [UniProt:Q93063]
exact_synonym: "SOTV" [HGNC:3513, EntrezGene:2132]
xref_analog: UniProt:Q93063
relationship: sequence_of IMR:0001395 ! Exostosin-2

[Term]
id: IMR:0001399
name: EXT2_MOUSE
exact_synonym: "EC 2.4.1.224" [UniProt:P70428]
exact_synonym: "EC 2.4.1.225" [UniProt:P70428]
exact_synonym: "exostoses (multiple) 2" [MGI:108050]
exact_synonym: "Exostosin-2" [UniProt:P70428]
exact_synonym: "Ext2" [UniProt:P70428, MGI:108050]
exact_synonym: "Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase" [UniProt:P70428]
exact_synonym: "Multiple exostoses protein 2 homolog" [UniProt:P70428]
xref_analog: UniProt:P70428
relationship: sequence_of IMR:0001395 ! Exostosin-2

[Term]
id: IMR:0001400
name: EXT3_DROME
exact_synonym: "BcDNA:LD21192" [FlyBase:FBgn0027535]
exact_synonym: "botv" [FlyBase:FBgn0027535, UniProt:Q9XZ08]
exact_synonym: "Botv" [FlyBase:FBgn0027535]
exact_synonym: "brother of tout-velu" [FlyBase:FBgn0027535]
exact_synonym: "CG15110" [FlyBase:FBgn0027535]
exact_synonym: "DEXT3" [FlyBase:FBgn0027535, UniProt:Q9XZ08]
exact_synonym: "Dextl3" [FlyBase:FBgn0027535]
exact_synonym: "Drosophila Ext-like 3" [FlyBase:FBgn0027535]
exact_synonym: "EC 2.4.1.223" [UniProt:Q9XZ08]
exact_synonym: "Exostosin-3" [UniProt:Q9XZ08]
exact_synonym: "Protein brother of tout-velu" [UniProt:Q9XZ08]
xref_analog: UniProt:Q9XZ08
relationship: sequence_of IMR:0001396 ! Exostosin

[Term]
id: IMR:0001401
name: KC1A_DROME
exact_synonym: "anon-WO03040301.93" [FlyBase:FBgn0015024]
exact_synonym: "anon-WO03040301.95" [FlyBase:FBgn0015024]
exact_synonym: "Casein kinase 1" [FlyBase:FBgn0015024]
exact_synonym: "Casein Kinase 1" [FlyBase:FBgn0015024]
exact_synonym: "casein kinase I" [FlyBase:FBgn0015024]
exact_synonym: "Casein kinase I isoform alpha" [UniProt:P54367]
exact_synonym: "Casein kinase Ialpha" [FlyBase:FBgn0015024]
exact_synonym: "CG2028" [FlyBase:FBgn0015024]
exact_synonym: "CK I" [FlyBase:FBgn0015024]
exact_synonym: "CK1" [FlyBase:FBgn0015024]
exact_synonym: "CK1a" [FlyBase:FBgn0015024]
exact_synonym: "CK1alpha" [FlyBase:FBgn0015024]
exact_synonym: "CKI" [FlyBase:FBgn0015024, UniProt:P54367]
exact_synonym: "CKI-alpha" [UniProt:P54367]
exact_synonym: "CkIa" [FlyBase:FBgn0015024]
exact_synonym: "CKIa" [FlyBase:FBgn0015024]
exact_synonym: "CkIalpha" [FlyBase:FBgn0015024, UniProt:P54367]
exact_synonym: "CKIalpha" [FlyBase:FBgn0015024]
exact_synonym: "DmCK1" [UniProt:P54367]
exact_synonym: "dmCK1" [FlyBase:FBgn0015024]
exact_synonym: "dmckI" [FlyBase:FBgn0015024]
exact_synonym: "EC 2.7.11.1" [UniProt:P54367]
exact_synonym: "l(1)G0492" [FlyBase:FBgn0015024]
xref_analog: UniProt:P54367
relationship: sequence_of IMR:0100810 ! CKI-alpha

[Term]
id: IMR:0001402
name: Q9TVJ1_CAEEL
exact_synonym: "egl-20" [UniProt:Q9TVJ1]
exact_synonym: "Protein W08D2.1, confirmed by transcript evidence" [UniProt:Q9TVJ1]
exact_synonym: "Wnt homolog" [UniProt:Q9TVJ1]
xref_analog: UniProt:Q9TVJ1
relationship: sequence_of IMR:0000003 ! Wnt

[Term]
id: IMR:0001403
name: O61720_CAEEL
exact_synonym: "Cytoplasmic signalling transducer" [UniProt:O61720]
exact_synonym: "mig-5" [UniProt:O61720]
exact_synonym: "Protein T05C12.6b, confirmed by transcript evidence" [UniProt:O61720]
xref_analog: UniProt:O61720
relationship: sequence_of IMR:0100755 ! Dsh family

[Term]
id: IMR:0001404
name: CBP
exact_synonym: "CREB-binding protein" []
is_a: IMR:0000426 ! p300/CBP

[Term]
id: IMR:0001405
name: p300
is_a: IMR:0000426 ! p300/CBP

[Term]
id: IMR:0001406
name: EP300_HUMAN
exact_synonym: "E1A binding protein p300" [HGNC:3373, EntrezGene:2033]
exact_synonym: "E1A-associated protein p300" [UniProt:Q09472]
exact_synonym: "E1A-BINDING PROTEIN, 300-KD" [MIM:602700]
exact_synonym: "EC 2.3.1.48" [UniProt:Q09472]
exact_synonym: "EP300" [UniProt:Q09472, MIM:602700, HGNC:3373, EntrezGene:2033]
exact_synonym: "Histone acetyltransferase p300" [UniProt:Q09472]
exact_synonym: "KAT3B" [HGNC:3373, EntrezGene:2033]
exact_synonym: "P300" [UniProt:Q09472, MIM:602700]
exact_synonym: "p300" [HGNC:3373, EntrezGene:2033]
exact_synonym: "p300 HAT" [UniProt:Q09472]
exact_synonym: "RSTS2" [EntrezGene:2033]
xref_analog: UniProt:Q09472
relationship: sequence_of IMR:0001405 ! p300

[Term]
id: IMR:0001407
name: Q8BJ14_MOUSE
exact_synonym: "E1A binding protein p300" [MGI:1276116]
exact_synonym: "Ep300" [MGI:1276116, UniProt:Q8BJ14]
exact_synonym: "KAT3B" [MGI:1276116]
exact_synonym: "p300" [MGI:1276116]
exact_synonym: "Putative uncharacterized protein" [UniProt:Q8BJ14]
xref_analog: UniProt:Q8BJ14
relationship: sequence_of IMR:0001405 ! p300

[Term]
id: IMR:0001408
name: Q91XT0_RAT
exact_synonym: "E1A binding protein p300" [RGD:620036]
exact_synonym: "E1A-binding protein" [UniProt:Q91XT0]
exact_synonym: "Ep300" [UniProt:Q91XT0, RGD:620036]
exact_synonym: "p300" [UniProt:Q91XT0]
xref_analog: UniProt:Q91XT0
relationship: sequence_of IMR:0001405 ! p300

[Term]
id: IMR:0001409
name: Gab
def: "Gab proteins contain a pleckstrin homology (PH) domain and binding sites for SH2 and SH3 domains. Gab family include mammalian Gab1, Gab2, Gab3, Drosophila Dos, and C. elegans Soc1." [PubMed:14662016]
exact_synonym: "Grb2-associated binder" []
is_a: IMR:0000345 ! docking protein

[Term]
id: IMR:0001410
name: Gab1
exact_synonym: "Grb2-associated binder 1" []
is_a: IMR:0001409 ! Gab

[Term]
id: IMR:0001411
name: Gab2
exact_synonym: "Grb2-associated binder 2" []
is_a: IMR:0001409 ! Gab

[Term]
id: IMR:0001412
name: Gab3
exact_synonym: "Grb2-associated binder 3" []
is_a: IMR:0001409 ! Gab

[Term]
id: IMR:0001413
name: GAB1_HUMAN
exact_synonym: "GAB1" [MIM:604439, UniProt:Q13480, EntrezGene:2549, HGNC:4066]
exact_synonym: "GRB2-associated binder 1" [UniProt:Q13480]
exact_synonym: "GRB2-associated binding protein 1" [MIM:604439, EntrezGene:2549, HGNC:4066]
exact_synonym: "GRB2-associated-binding protein 1" [UniProt:Q13480]
exact_synonym: "Growth factor receptor bound protein 2-associated protein 1" [UniProt:Q13480]
xref_analog: UniProt:Q13480
relationship: sequence_of IMR:0001410 ! Gab1

[Term]
id: IMR:0001414
name: GAB1_MOUSE
exact_synonym: "Gab1" [MGI:108088, UniProt:Q9QYY0]
exact_synonym: "GRB2-associated binder 1" [UniProt:Q9QYY0]
exact_synonym: "GRB2-associated-binding protein 1" [UniProt:Q9QYY0]
exact_synonym: "Growth factor receptor bound protein 2-associated protein 1" [UniProt:Q9QYY0]
exact_synonym: "growth factor receptor bound protein 2-associated protein 1" [MGI:108088]
xref_analog: UniProt:Q9QYY0
relationship: sequence_of IMR:0001410 ! Gab1

[Term]
id: IMR:0001415
name: GAB2_HUMAN
exact_synonym: "GAB2" [EntrezGene:9846, UniProt:Q9UQC2, MIM:606203, HGNC:14458]
exact_synonym: "GRB2-associated binder 2" [UniProt:Q9UQC2]
exact_synonym: "GRB2-associated binding protein 2" [EntrezGene:9846, MIM:606203, HGNC:14458]
exact_synonym: "GRB2-associated-binding protein 2" [UniProt:Q9UQC2]
exact_synonym: "Growth factor receptor bound protein 2-associated protein 2" [UniProt:Q9UQC2]
exact_synonym: "KIAA0571" [EntrezGene:9846, UniProt:Q9UQC2, MIM:606203, HGNC:14458]
exact_synonym: "pp100" [UniProt:Q9UQC2]
xref_analog: UniProt:Q9UQC2
relationship: sequence_of IMR:0001411 ! Gab2

[Term]
id: IMR:0001416
name: GAB2_MOUSE
exact_synonym: "Gab2" [UniProt:Q9Z1S8, MGI:1333854]
exact_synonym: "GRB2-associated binder 2" [UniProt:Q9Z1S8]
exact_synonym: "GRB2-associated-binding protein 2" [UniProt:Q9Z1S8]
exact_synonym: "Growth factor receptor bound protein 2-associated protein 2" [UniProt:Q9Z1S8]
exact_synonym: "growth factor receptor bound protein 2-associated protein 2" [MGI:1333854]
exact_synonym: "p97" [MGI:1333854]
exact_synonym: "PH domain-containing adaptor molecule p97" [UniProt:Q9Z1S8]
xref_analog: UniProt:Q9Z1S8
relationship: sequence_of IMR:0001411 ! Gab2

[Term]
id: IMR:0001417
name: GAB2_RAT
exact_synonym: "Gab2" [RGD:621367, UniProt:Q9EQH1]
exact_synonym: "GRB2-associated binder 2" [UniProt:Q9EQH1]
exact_synonym: "GRB2-associated binding protein 2" [RGD:621367]
exact_synonym: "GRB2-associated-binding protein 2" [UniProt:Q9EQH1]
exact_synonym: "Growth factor receptor bound protein 2-associated protein 2" [UniProt:Q9EQH1]
xref_analog: UniProt:Q9EQH1
relationship: sequence_of IMR:0001411 ! Gab2

[Term]
id: IMR:0001418
name: GAB3_HUMAN
exact_synonym: "GAB3" [MIM:300482, UniProt:Q8WWW8, HGNC:17515, EntrezGene:139716]
exact_synonym: "GRB2-associated binder 3" [UniProt:Q8WWW8]
exact_synonym: "GRB2-associated binding protein 3" [MIM:300482, HGNC:17515, EntrezGene:139716]
exact_synonym: "GRB2-associated-binding protein 3" [UniProt:Q8WWW8]
exact_synonym: "Growth factor receptor bound protein 2-associated protein 3" [UniProt:Q8WWW8]
xref_analog: UniProt:Q8WWW8
relationship: sequence_of IMR:0001412 ! Gab3

[Term]
id: IMR:0001419
name: GAB3_MOUSE
exact_synonym: "Gab3" [MGI:2387324, UniProt:Q8BSM5]
exact_synonym: "GRB2-associated binder 3" [UniProt:Q8BSM5]
exact_synonym: "GRB2-associated-binding protein 3" [UniProt:Q8BSM5]
exact_synonym: "Growth factor receptor bound protein 2-associated protein 3" [UniProt:Q8BSM5]
exact_synonym: "growth factor receptor bound protein 2-associated protein 3" [MGI:2387324]
xref_analog: UniProt:Q8BSM5
relationship: sequence_of IMR:0001412 ! Gab3

[Term]
id: IMR:0001420
name: DOS_DROME
exact_synonym: "CG1044" [FlyBase:FBgn0016794]
exact_synonym: "daughter of sevenless" [FlyBase:FBgn0016794]
exact_synonym: "dos" [FlyBase:FBgn0016794, UniProt:Q9VZZ9]
exact_synonym: "Dos" [FlyBase:FBgn0016794]
exact_synonym: "DOS" [FlyBase:FBgn0016794]
exact_synonym: "E(csw)3A" [FlyBase:FBgn0016794]
exact_synonym: "E(csw[CS])3A" [FlyBase:FBgn0016794]
exact_synonym: "Enhancer of corkscrew-CS" [FlyBase:FBgn0016794]
exact_synonym: "Protein daughter of sevenless" [UniProt:Q9VZZ9]
exact_synonym: "Su(sev)3A" [FlyBase:FBgn0016794]
exact_synonym: "Su(sev[S11])3A" [FlyBase:FBgn0016794]
exact_synonym: "Suppressor of sevenless-S11" [FlyBase:FBgn0016794]
xref_analog: UniProt:Q9VZZ9
relationship: sequence_of IMR:0001409 ! Gab

[Term]
id: IMR:0001421
name: Q20280_CAEEL
exact_synonym: "Multisubstrate adaptor protein SOC-1" [UniProt:Q20280]
exact_synonym: "soc-1" [UniProt:Q20280]
exact_synonym: "Suppressor of clr protein 1" [UniProt:Q20280]
xref_analog: UniProt:Q20280
relationship: sequence_of IMR:0001409 ! Gab

[Term]
id: IMR:0001422
name: ISGF3
def: "ISGF3 is a heterotrimer of STAT1, STAT2 and p48/ISGF3gamma/IRF9." [PubMed:11050435, PubMed:12040185]
exact_synonym: "IFN-stimulated gene factor 3" []
exact_synonym: "interferon-stimulated gene factor 3" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0001423
name: GAF
def: "STAT1 dimers form the IFNgamma-activated factor (GAF)." [PubMed:11050435, PubMed:12040185]
exact_synonym: "gamma-activated factor" []
exact_synonym: "IFNgamma-activated factor" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0001424
name: BMP-2
exact_synonym: "BMP2" []
exact_synonym: "Bone morphogenetic protein 2" []
is_a: IMR:0003083 ! BMP-2 subfamily

[Term]
id: IMR:0001425
name: BMPRI
is_a: IMR:0000093 ! TGF-beta receptor type I

[Term]
id: IMR:0001426
name: BMP-3
exact_synonym: "BMP3" []
exact_synonym: "Bone morphogenetic protein 3" []
is_a: IMR:0000040 ! BMP family

[Term]
id: IMR:0001427
name: BMP-3b
exact_synonym: "BMP3b" []
exact_synonym: "Bone morphogenetic protein 3b" []
exact_synonym: "GDF-10" []
exact_synonym: "GDF10" []
is_a: IMR:0000040 ! BMP family

[Term]
id: IMR:0001428
name: BMP-4
exact_synonym: "BMP4" []
exact_synonym: "Bone morphogenetic protein 4" []
is_a: IMR:0003083 ! BMP-2 subfamily

[Term]
id: IMR:0001429
name: BMP-5
exact_synonym: "BMP5" []
exact_synonym: "Bone morphogenetic protein 5" []
is_a: IMR:0003084 ! BMP-5 subfamily

[Term]
id: IMR:0001430
name: BMP-6
exact_synonym: "BMP6" []
exact_synonym: "Bone morphogenetic protein 6" []
exact_synonym: "Vgr-1" []
is_a: IMR:0003084 ! BMP-5 subfamily

[Term]
id: IMR:0001431
name: BMP-7
exact_synonym: "BMP7" []
exact_synonym: "Bone morphogenetic protein 7" []
exact_synonym: "OP-1" []
is_a: IMR:0003084 ! BMP-5 subfamily

[Term]
id: IMR:0001432
name: BMP-8a
exact_synonym: "BMP8a" []
exact_synonym: "Bone morphogenetic protein 8a" []
exact_synonym: "OP-2" []
is_a: IMR:0003084 ! BMP-5 subfamily

[Term]
id: IMR:0001433
name: BMP-8b
exact_synonym: "BMP8b" []
exact_synonym: "Bone morphogenetic protein 8b" []
exact_synonym: "OP-3" []
is_a: IMR:0003084 ! BMP-5 subfamily

[Term]
id: IMR:0001434
name: BMP-10
exact_synonym: "BMP10" []
exact_synonym: "Bone morphogenetic protein 10" []
is_a: IMR:0000040 ! BMP family

[Term]
id: IMR:0001435
name: BMP-15
exact_synonym: "BMP15" []
exact_synonym: "Bone morphogenetic protein 15" []
exact_synonym: "GDF-9b" []
exact_synonym: "GDF9b" []
exact_synonym: "Growth/differentiation factor 9B" []
is_a: IMR:0000040 ! BMP family

[Term]
id: IMR:0001436
name: GDF-11
exact_synonym: "BMP-11" []
exact_synonym: "BMP11" []
exact_synonym: "Bone morphogenetic protein 11" []
exact_synonym: "GDF11" []
exact_synonym: "Growth/differentiation factor 11" []
is_a: IMR:0000040 ! BMP family

[Term]
id: IMR:0001437
name: GDF-2
exact_synonym: "BMP-9" []
exact_synonym: "BMP9" []
exact_synonym: "Bone morphogenetic protein 9" []
exact_synonym: "Growth/differentiation factor-2" []
is_a: IMR:0000040 ! BMP family

[Term]
id: IMR:0001438
name: CD14
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0001439
name: MD-2
exact_synonym: "ESOP-1" []
exact_synonym: "LY96" []
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0001440
name: TLR4
exact_synonym: "Toll-like receptor 4" []
is_a: IMR:0000124 ! TLR

[Term]
id: IMR:0001441
name: CD14_HUMAN
exact_synonym: "CD14" [HGNC:1628, UniProt:P08571, MIM:158120, EntrezGene:929]
exact_synonym: "CD14 molecule" [HGNC:1628, EntrezGene:929]
exact_synonym: "Monocyte differentiation antigen CD14" [UniProt:P08571, MIM:158120]
exact_synonym: "Monocyte differentiation antigen CD14, membrane-bound form" [UniProt:P08571]
exact_synonym: "Monocyte differentiation antigen CD14, urinary form" [UniProt:P08571]
exact_synonym: "Myeloid cell-specific leucine-rich glycoprotein" [UniProt:P08571, MIM:158120]
xref_analog: UniProt:P08571
relationship: sequence_of IMR:0001438 ! CD14

[Term]
id: IMR:0001442
name: CD14_MOUSE
exact_synonym: "Cd14" [MGI:88318, UniProt:P10810]
exact_synonym: "CD14" [UniProt:P10810]
exact_synonym: "CD14 antigen" [MGI:88318]
exact_synonym: "Monocyte differentiation antigen CD14" [UniProt:P10810]
exact_synonym: "Myeloid cell-specific leucine-rich glycoprotein" [UniProt:P10810]
xref_analog: UniProt:P10810
relationship: sequence_of IMR:0001438 ! CD14

[Term]
id: IMR:0001443
name: CD14_RAT
exact_synonym: "Cd14" [UniProt:Q63691, RGD:620588]
exact_synonym: "CD14" [UniProt:Q63691]
exact_synonym: "CD14 molecule" [RGD:620588]
exact_synonym: "Monocyte differentiation antigen CD14" [UniProt:Q63691]
exact_synonym: "Myeloid cell-specific leucine-rich glycoprotein" [UniProt:Q63691]
xref_analog: UniProt:Q63691
relationship: sequence_of IMR:0001438 ! CD14

[Term]
id: IMR:0001444
name: LY96_HUMAN
exact_synonym: "ESOP-1" [UniProt:Q9Y6Y9, EntrezGene:23643]
exact_synonym: "ESOP1" [UniProt:Q9Y6Y9]
exact_synonym: "Ly-96" [UniProt:Q9Y6Y9]
exact_synonym: "ly-96" [EntrezGene:23643]
exact_synonym: "LY96" [MIM:605243, UniProt:Q9Y6Y9, HGNC:17156, EntrezGene:23643]
exact_synonym: "Lymphocyte antigen 96" [MIM:605243, UniProt:Q9Y6Y9]
exact_synonym: "lymphocyte antigen 96" [HGNC:17156, EntrezGene:23643]
exact_synonym: "MD-2" [HGNC:17156, EntrezGene:23643]
exact_synonym: "MD2" [MIM:605243, UniProt:Q9Y6Y9, EntrezGene:23643]
exact_synonym: "MD2 PROTEIN" [MIM:605243]
exact_synonym: "Protein MD-2" [UniProt:Q9Y6Y9]
xref_analog: UniProt:Q9Y6Y9
relationship: sequence_of IMR:0001439 ! MD-2

[Term]
id: IMR:0001445
name: LY96_MOUSE
exact_synonym: "ESOP-1" [UniProt:Q9JHF9, MGI:1341909]
exact_synonym: "Esop1" [UniProt:Q9JHF9]
exact_synonym: "Ly-96" [UniProt:Q9JHF9]
exact_synonym: "Ly96" [UniProt:Q9JHF9, MGI:1341909]
exact_synonym: "Lymphocyte antigen 96" [UniProt:Q9JHF9]
exact_synonym: "lymphocyte antigen 96" [MGI:1341909]
exact_synonym: "MD-2" [MGI:1341909]
exact_synonym: "Md2" [UniProt:Q9JHF9]
exact_synonym: "MD2" [MGI:1341909]
exact_synonym: "myeloid differentiation factor-2" [MGI:1341909]
exact_synonym: "Protein MD-2" [UniProt:Q9JHF9]
xref_analog: UniProt:Q9JHF9
relationship: sequence_of IMR:0001439 ! MD-2

[Term]
id: IMR:0001446
name: TLR4_HUMAN
exact_synonym: "ARMD10" [EntrezGene:7099]
exact_synonym: "CD284" [UniProt:O00206, HGNC:11850, EntrezGene:7099]
exact_synonym: "hToll" [UniProt:O00206, HGNC:11850, EntrezGene:7099]
exact_synonym: "TLR4" [UniProt:O00206, HGNC:11850, EntrezGene:7099]
exact_synonym: "TOLL" [EntrezGene:7099]
exact_synonym: "Toll-like receptor 4" [UniProt:O00206]
exact_synonym: "toll-like receptor 4" [HGNC:11850, EntrezGene:7099]
xref_analog: UniProt:O00206
relationship: sequence_of IMR:0001440 ! TLR4

[Term]
id: IMR:0001447
name: TLR4_MOUSE
exact_synonym: "CD284" [UniProt:Q9QUK6]
exact_synonym: "lipopolysaccharide response" [MGI:96824]
exact_synonym: "Lps" [MGI:96824, UniProt:Q9QUK6]
exact_synonym: "Rasl2-8" [MGI:96824]
exact_synonym: "Tlr4" [MGI:96824, UniProt:Q9QUK6]
exact_synonym: "Toll-like receptor 4" [UniProt:Q9QUK6]
exact_synonym: "toll-like receptor 4" [MGI:96824]
xref_analog: UniProt:Q9QUK6
relationship: sequence_of IMR:0001440 ! TLR4

[Term]
id: IMR:0001448
name: TLR4_RAT
exact_synonym: "CD284" [UniProt:Q9QX05]
exact_synonym: "Tlr4" [RGD:3870, UniProt:Q9QX05]
exact_synonym: "Toll-like receptor 4" [UniProt:Q9QX05]
exact_synonym: "toll-like receptor 4" [RGD:3870]
exact_synonym: "Toll4" [UniProt:Q9QX05]
xref_analog: UniProt:Q9QX05
relationship: sequence_of IMR:0001440 ! TLR4

[Term]
id: IMR:0001449
name: TLR1
exact_synonym: "Toll-like receptor 1" []
is_a: IMR:0000124 ! TLR

[Term]
id: IMR:0001450
name: TLR2
exact_synonym: "Toll-like receptor 2" []
is_a: IMR:0000124 ! TLR

[Term]
id: IMR:0001451
name: TLR5
exact_synonym: "Toll-like receptor 5" []
is_a: IMR:0000124 ! TLR

[Term]
id: IMR:0001452
name: TLR3
exact_synonym: "Toll-like receptor 3" []
is_a: IMR:0000124 ! TLR

[Term]
id: IMR:0001453
name: TLR3_HUMAN
exact_synonym: "CD283" [EntrezGene:7098, UniProt:O15455, HGNC:11849]
exact_synonym: "TLR3" [EntrezGene:7098, UniProt:O15455, MIM:603029, HGNC:11849]
exact_synonym: "Toll-like receptor 3" [UniProt:O15455, MIM:603029]
exact_synonym: "toll-like receptor 3" [EntrezGene:7098, HGNC:11849]
xref_analog: UniProt:O15455
relationship: sequence_of IMR:0001452 ! TLR3

[Term]
id: IMR:0001454
name: TLR3_MOUSE
exact_synonym: "CD283" [UniProt:Q99MB1]
exact_synonym: "Tlr3" [MGI:2156367, UniProt:Q99MB1]
exact_synonym: "Toll-like receptor 3" [UniProt:Q99MB1]
exact_synonym: "toll-like receptor 3" [MGI:2156367]
xref_analog: UniProt:Q99MB1
relationship: sequence_of IMR:0001452 ! TLR3

[Term]
id: IMR:0001455
name: TLR6
exact_synonym: "Toll-like receptor 6" []
is_a: IMR:0000124 ! TLR

[Term]
id: IMR:0001456
name: TLR6_HUMAN
exact_synonym: "CD286" [EntrezGene:10333, UniProt:Q9Y2C9, HGNC:16711]
exact_synonym: "TLR6" [EntrezGene:10333, MIM:605403, UniProt:Q9Y2C9, HGNC:16711]
exact_synonym: "Toll-like receptor 6" [MIM:605403, UniProt:Q9Y2C9]
exact_synonym: "toll-like receptor 6" [EntrezGene:10333, HGNC:16711]
xref_analog: UniProt:Q9Y2C9
relationship: sequence_of IMR:0001455 ! TLR6

[Term]
id: IMR:0001457
name: TLR6_MOUSE
exact_synonym: "CD286" [UniProt:Q9EPW9]
exact_synonym: "Tlr6" [MGI:1341296, UniProt:Q9EPW9]
exact_synonym: "Toll-like receptor 6" [UniProt:Q9EPW9]
exact_synonym: "toll-like receptor 6" [MGI:1341296]
xref_analog: UniProt:Q9EPW9
relationship: sequence_of IMR:0001455 ! TLR6

[Term]
id: IMR:0001458
name: TLR7
exact_synonym: "Toll-like receptor 7" []
is_a: IMR:0000124 ! TLR

[Term]
id: IMR:0001459
name: TLR7_HUMAN
exact_synonym: "TLR7" [EntrezGene:51284, HGNC:15631, UniProt:Q9NYK1, MIM:300365]
exact_synonym: "Toll-like receptor 7" [UniProt:Q9NYK1, MIM:300365]
exact_synonym: "toll-like receptor 7" [EntrezGene:51284, HGNC:15631]
xref_analog: UniProt:Q9NYK1
relationship: sequence_of IMR:0001458 ! TLR7

[Term]
id: IMR:0001460
name: TLR7_MOUSE
exact_synonym: "Tlr7" [MGI:2176882, UniProt:P58681]
exact_synonym: "Toll-like receptor 7" [UniProt:P58681]
exact_synonym: "toll-like receptor 7" [MGI:2176882]
xref_analog: UniProt:P58681
relationship: sequence_of IMR:0001458 ! TLR7

[Term]
id: IMR:0001461
name: TLR8
exact_synonym: "Toll-like receptor 8" []
is_a: IMR:0000124 ! TLR

[Term]
id: IMR:0001462
name: TLR8_HUMAN
exact_synonym: "CD288" [UniProt:Q9NR97, EntrezGene:51311, HGNC:15632]
exact_synonym: "MGC119599" [EntrezGene:51311]
exact_synonym: "MGC119600" [EntrezGene:51311]
exact_synonym: "TLR8" [UniProt:Q9NR97, EntrezGene:51311, MIM:300366, HGNC:15632]
exact_synonym: "Toll-like receptor 8" [UniProt:Q9NR97, MIM:300366]
exact_synonym: "toll-like receptor 8" [EntrezGene:51311, HGNC:15632]
xref_analog: UniProt:Q9NR97
relationship: sequence_of IMR:0001461 ! TLR8

[Term]
id: IMR:0001463
name: TLR8_MOUSE
exact_synonym: "CD288" [UniProt:P58682]
exact_synonym: "Tlr8" [MGI:2176887, UniProt:P58682]
exact_synonym: "Toll-like receptor 8" [UniProt:P58682]
exact_synonym: "toll-like receptor 8" [MGI:2176887]
xref_analog: UniProt:P58682
relationship: sequence_of IMR:0001461 ! TLR8

[Term]
id: IMR:0001464
name: TLR9
exact_synonym: "Toll-like receptor 9" []
is_a: IMR:0000124 ! TLR

[Term]
id: IMR:0001465
name: TLR9_HUMAN
exact_synonym: "CD289" [EntrezGene:54106, UniProt:Q9NR96, HGNC:15633]
exact_synonym: "TLR9" [EntrezGene:54106, MIM:605474, UniProt:Q9NR96, HGNC:15633]
exact_synonym: "Toll-like receptor 9" [MIM:605474, UniProt:Q9NR96]
exact_synonym: "toll-like receptor 9" [EntrezGene:54106, HGNC:15633]
xref_analog: UniProt:Q9NR96
relationship: sequence_of IMR:0001464 ! TLR9

[Term]
id: IMR:0001466
name: TLR9_MOUSE
exact_synonym: "CD289" [UniProt:Q9EQU3]
exact_synonym: "Tlr9" [UniProt:Q9EQU3, MGI:1932389]
exact_synonym: "Toll-like receptor 9" [UniProt:Q9EQU3]
exact_synonym: "toll-like receptor 9" [MGI:1932389]
xref_analog: UniProt:Q9EQU3
relationship: sequence_of IMR:0001464 ! TLR9

[Term]
id: IMR:0001467
name: TOLL_DROME
exact_synonym: "CG5490" [FlyBase:FBgn0262473]
exact_synonym: "CT17414" [FlyBase:FBgn0262473]
exact_synonym: "dToll" [FlyBase:FBgn0262473]
exact_synonym: "dToll1" [FlyBase:FBgn0262473]
exact_synonym: "Fs(1)Tl" [FlyBase:FBgn0262473]
exact_synonym: "Fs(3)Tl" [FlyBase:FBgn0262473]
exact_synonym: "mat(3)9" [FlyBase:FBgn0262473]
exact_synonym: "mel(3)10" [FlyBase:FBgn0262473]
exact_synonym: "mel(3)9" [FlyBase:FBgn0262473]
exact_synonym: "Protein toll" [UniProt:P08953]
exact_synonym: "T1" [FlyBase:FBgn0262473]
exact_synonym: "Tl" [UniProt:P08953, FlyBase:FBgn0262473]
exact_synonym: "tl" [FlyBase:FBgn0262473]
exact_synonym: "toll" [FlyBase:FBgn0262473]
exact_synonym: "Toll" [FlyBase:FBgn0262473]
exact_synonym: "toll-1" [FlyBase:FBgn0262473]
exact_synonym: "Toll-1" [FlyBase:FBgn0262473]
xref_analog: UniProt:P08953
relationship: sequence_of IMR:0000124 ! TLR

[Term]
id: IMR:0001468
name: DOCK180
exact_synonym: "DOCK1" []
is_a: IMR:0001469 ! DOCK

[Term]
id: IMR:0001469
name: DOCK
def: "Superfamily members of DOCK180 possess the DHR-2 domain and bind to and exchange GDP for GTP on either Rac or Cdc42." [PubMed:12432077]
is_a: IMR:0001954 ! RhoGEF

[Term]
id: IMR:0001470
name: DOCK2
is_a: IMR:0001469 ! DOCK

[Term]
id: IMR:0001471
name: DOCK3
is_a: IMR:0001469 ! DOCK

[Term]
id: IMR:0001472
name: DOCK4
is_a: IMR:0001469 ! DOCK

[Term]
id: IMR:0001473
name: DOCK5
is_a: IMR:0001469 ! DOCK

[Term]
id: IMR:0001474
name: DOCK6
is_a: IMR:0001469 ! DOCK

[Term]
id: IMR:0001475
name: DOCK7
is_a: IMR:0001469 ! DOCK

[Term]
id: IMR:0001476
name: DOCK8
is_a: IMR:0001469 ! DOCK

[Term]
id: IMR:0001477
name: DOCK9
is_a: IMR:0001469 ! DOCK

[Term]
id: IMR:0001478
name: DOCK10
is_a: IMR:0001469 ! DOCK

[Term]
id: IMR:0001479
name: DOCK1_HUMAN
exact_synonym: "180 kDa protein downstream of CRK" [UniProt:Q14185]
exact_synonym: "ced5" [EntrezGene:1793, HGNC:2987]
exact_synonym: "CED5, C. ELEGANS, HOMOLOG OF" [MIM:601403]
exact_synonym: "dedicator of cytokinesis 1" [EntrezGene:1793, MIM:601403, HGNC:2987]
exact_synonym: "Dedicator of cytokinesis protein 1" [UniProt:Q14185]
exact_synonym: "DOCK, 180-KD" [MIM:601403]
exact_synonym: "DOCK1" [UniProt:Q14185, EntrezGene:1793, MIM:601403, HGNC:2987]
exact_synonym: "DOCK180" [UniProt:Q14185, EntrezGene:1793, MIM:601403, HGNC:2987]
exact_synonym: "DOWNSTREAM OF CRK-BINDING PROTEIN, 180-KD" [MIM:601403]
xref_analog: UniProt:Q14185
relationship: sequence_of IMR:0001468 ! DOCK180

[Term]
id: IMR:0001480
name: DOCK1_MOUSE
exact_synonym: "180 kDa protein downstream of CRK" [UniProt:Q8BUR4]
exact_synonym: "dedicator of cytokinesis 1" [MGI:2429765]
exact_synonym: "Dedicator of cytokinesis protein 1" [UniProt:Q8BUR4]
exact_synonym: "Dock1" [MGI:2429765, UniProt:Q8BUR4]
exact_synonym: "DOCK180" [UniProt:Q8BUR4]
exact_synonym: "Dock180" [MGI:2429765]
xref_analog: UniProt:Q8BUR4
relationship: sequence_of IMR:0001468 ! DOCK180

[Term]
id: IMR:0001481
name: DOCK2_HUMAN
exact_synonym: "dedicator of cytokinesis 2" [HGNC:2988, MIM:603122, EntrezGene:1794]
exact_synonym: "Dedicator of cytokinesis protein 2" [UniProt:Q92608]
exact_synonym: "DOCK2" [HGNC:2988, UniProt:Q92608, MIM:603122, EntrezGene:1794]
exact_synonym: "FLJ46592" [EntrezGene:1794]
exact_synonym: "KIAA0209" [HGNC:2988, UniProt:Q92608, EntrezGene:1794]
xref_analog: UniProt:Q92608
relationship: sequence_of IMR:0001470 ! DOCK2

[Term]
id: IMR:0001482
name: DOCK2_MOUSE
exact_synonym: "CED-5" [MGI:2149010]
exact_synonym: "dedicator of cyto-kinesis 2" [MGI:2149010]
exact_synonym: "Dedicator of cytokinesis protein 2" [UniProt:Q8C3J5]
exact_synonym: "Dock2" [MGI:2149010, UniProt:Q8C3J5]
exact_synonym: "Hch" [MGI:2149010]
exact_synonym: "MBC" [MGI:2149010]
exact_synonym: "Protein Hch" [UniProt:Q8C3J5]
xref_analog: UniProt:Q8C3J5
relationship: sequence_of IMR:0001470 ! DOCK2

[Term]
id: IMR:0001483
name: DOCK3_HUMAN
exact_synonym: "dedicator of cytokinesis 3" [EntrezGene:1795, HGNC:2989, MIM:603123]
exact_synonym: "Dedicator of cytokinesis protein 3" [UniProt:Q8IZD9]
exact_synonym: "DOCK3" [EntrezGene:1795, HGNC:2989, UniProt:Q8IZD9, MIM:603123]
exact_synonym: "KIAA0299" [EntrezGene:1795, HGNC:2989, UniProt:Q8IZD9]
exact_synonym: "MOCA" [EntrezGene:1795, HGNC:2989, UniProt:Q8IZD9]
exact_synonym: "Modifier of cell adhesion" [UniProt:Q8IZD9]
exact_synonym: "PBP" [EntrezGene:1795, HGNC:2989, UniProt:Q8IZD9]
exact_synonym: "Presenilin-binding protein" [UniProt:Q8IZD9]
xref_analog: UniProt:Q8IZD9
relationship: sequence_of IMR:0001471 ! DOCK3

[Term]
id: IMR:0001484
name: DOCK3_MOUSE
exact_synonym: "dedicator of cyto-kinesis 3" [MGI:2429763]
exact_synonym: "Dedicator of cytokinesis protein 3" [UniProt:Q8CIQ7]
exact_synonym: "Dock3" [UniProt:Q8CIQ7, MGI:2429763]
exact_synonym: "Moca" [UniProt:Q8CIQ7, MGI:2429763]
exact_synonym: "Modifier of cell adhesion" [UniProt:Q8CIQ7]
exact_synonym: "PBP" [UniProt:Q8CIQ7, MGI:2429763]
exact_synonym: "Presenilin-binding protein" [UniProt:Q8CIQ7]
xref_analog: UniProt:Q8CIQ7
relationship: sequence_of IMR:0001471 ! DOCK3

[Term]
id: IMR:0001485
name: DOCK4_HUMAN
exact_synonym: "dedicator of cytokinesis 4" [MIM:607679, EntrezGene:9732, HGNC:19192]
exact_synonym: "Dedicator of cytokinesis protein 4" [UniProt:Q8N1I0]
exact_synonym: "DOCK4" [UniProt:Q8N1I0, MIM:607679, EntrezGene:9732, HGNC:19192]
exact_synonym: "FLJ34238" [EntrezGene:9732, HGNC:19192]
exact_synonym: "KIAA0716" [UniProt:Q8N1I0, MIM:607679, EntrezGene:9732, HGNC:19192]
exact_synonym: "MGC134911" [EntrezGene:9732]
exact_synonym: "MGC134912" [EntrezGene:9732]
xref_analog: UniProt:Q8N1I0
relationship: sequence_of IMR:0001472 ! DOCK4

[Term]
id: IMR:0001486
name: DOCK4_MOUSE
exact_synonym: "dedicator of cytokinesis 4" [MGI:1918006]
exact_synonym: "Dedicator of cytokinesis protein 4" [UniProt:P59764]
exact_synonym: "Dock4" [UniProt:P59764, MGI:1918006]
exact_synonym: "EST N28122" [MGI:1918006]
exact_synonym: "Kiaa0716" [UniProt:P59764]
xref_analog: UniProt:P59764
relationship: sequence_of IMR:0001472 ! DOCK4

[Term]
id: IMR:0001487
name: DOCK5_HUMAN
exact_synonym: "dedicator of cytokinesis 5" [HGNC:23476, EntrezGene:80005]
exact_synonym: "Dedicator of cytokinesis protein 5" [UniProt:Q9H7D0]
exact_synonym: "DKFZp451J181" [EntrezGene:80005]
exact_synonym: "DKFZp779M164" [EntrezGene:80005]
exact_synonym: "DKFZp781J211" [EntrezGene:80005]
exact_synonym: "DOCK5" [HGNC:23476, EntrezGene:80005, UniProt:Q9H7D0]
exact_synonym: "FLJ21034" [HGNC:23476]
xref_analog: UniProt:Q9H7D0
relationship: sequence_of IMR:0001473 ! DOCK5

[Term]
id: IMR:0001488
name: DOCK6_HUMAN
exact_synonym: "dedicator of cytokinesis 6" [HGNC:19189, EntrezGene:57572]
exact_synonym: "Dedicator of cytokinesis protein 6" [UniProt:Q96HP0]
exact_synonym: "DOCK6" [HGNC:19189, EntrezGene:57572, UniProt:Q96HP0]
exact_synonym: "KIAA1395" [HGNC:19189, UniProt:Q96HP0]
exact_synonym: "ZIR1" [HGNC:19189, EntrezGene:57572]
xref_analog: UniProt:Q96HP0
relationship: sequence_of IMR:0001474 ! DOCK6

[Term]
id: IMR:0001489
name: DOCK6_MOUSE
exact_synonym: "dedicator of cytokinesis 6" [MGI:1914789]
exact_synonym: "Dedicator of cytokinesis protein 6" [UniProt:Q8VDR9]
exact_synonym: "Dock6" [MGI:1914789, UniProt:Q8VDR9]
exact_synonym: "Kiaa1395" [UniProt:Q8VDR9]
xref_analog: UniProt:Q8VDR9
relationship: sequence_of IMR:0001474 ! DOCK6

[Term]
id: IMR:0001490
name: DOCK7_HUMAN
exact_synonym: "dedicator of cytokinesis 7" [EntrezGene:85440, HGNC:19190]
exact_synonym: "Dedicator of cytokinesis protein 7" [UniProt:Q96N67]
exact_synonym: "DOCK7" [EntrezGene:85440, HGNC:19190, UniProt:Q96N67]
exact_synonym: "KIAA1771" [EntrezGene:85440, HGNC:19190, UniProt:Q96N67]
exact_synonym: "ZIR2" [EntrezGene:85440, HGNC:19190]
xref_analog: UniProt:Q96N67
relationship: sequence_of IMR:0001475 ! DOCK7

[Term]
id: IMR:0001491
name: DOCK7_MOUSE
exact_synonym: "dedicator of cytokinesis 7" [MGI:1914549]
exact_synonym: "Dedicator of cytokinesis protein 7" [UniProt:Q8R1A4]
exact_synonym: "Dock7" [MGI:1914549, UniProt:Q8R1A4]
exact_synonym: "Gm430" [UniProt:Q8R1A4]
exact_synonym: "Kiaa1771" [UniProt:Q8R1A4]
exact_synonym: "LOC242555" [MGI:1914549]
exact_synonym: "m" [MGI:1914549]
xref_analog: UniProt:Q8R1A4
relationship: sequence_of IMR:0001475 ! DOCK7

[Term]
id: IMR:0001492
name: DOCK8_HUMAN
exact_synonym: "dedicator of cytokinesis 8" [EntrezGene:81704, HGNC:19191]
exact_synonym: "Dedicator of cytokinesis protein 8" [UniProt:Q8NF50]
exact_synonym: "DOCK8" [EntrezGene:81704, HGNC:19191, UniProt:Q8NF50]
exact_synonym: "FLJ00026" [EntrezGene:81704, HGNC:19191]
exact_synonym: "FLJ00152" [EntrezGene:81704, HGNC:19191]
exact_synonym: "FLJ00346" [EntrezGene:81704, HGNC:19191]
exact_synonym: "MRD2" [EntrezGene:81704]
exact_synonym: "ZIR8" [EntrezGene:81704, HGNC:19191]
xref_analog: UniProt:Q8NF50
relationship: sequence_of IMR:0001476 ! DOCK8

[Term]
id: IMR:0001493
name: DOCK8_MOUSE
exact_synonym: "dedicator of cytokinesis 8" [MGI:1921396]
exact_synonym: "Dedicator of cytokinesis protein 8" [UniProt:Q8C147]
exact_synonym: "Dock8" [UniProt:Q8C147, MGI:1921396]
xref_analog: UniProt:Q8C147
relationship: sequence_of IMR:0001476 ! DOCK8

[Term]
id: IMR:0001494
name: DOCK9_HUMAN
exact_synonym: "Cdc42 guanine nucleotide exchange factor zizimin-1" [UniProt:Q9BZ29]
exact_synonym: "dedicator of cytokinesis 9" [MIM:607325, EntrezGene:23348, HGNC:14132]
exact_synonym: "Dedicator of cytokinesis protein 9" [UniProt:Q9BZ29]
exact_synonym: "DKFZp686C11110" [EntrezGene:23348]
exact_synonym: "DKFZp686D2047" [EntrezGene:23348]
exact_synonym: "DKFZp686N04132" [EntrezGene:23348]
exact_synonym: "DOCK9" [UniProt:Q9BZ29, MIM:607325, EntrezGene:23348, HGNC:14132]
exact_synonym: "FLJ11949" [EntrezGene:23348]
exact_synonym: "FLJ16744" [EntrezGene:23348]
exact_synonym: "FLJ44528" [EntrezGene:23348]
exact_synonym: "FLJ45282" [EntrezGene:23348]
exact_synonym: "FLJ45601" [EntrezGene:23348]
exact_synonym: "KIAA1058" [UniProt:Q9BZ29, MIM:607325, EntrezGene:23348, HGNC:14132]
exact_synonym: "KIAA1085" [EntrezGene:23348]
exact_synonym: "ZIZ1" [MIM:607325, EntrezGene:23348, HGNC:14132]
exact_synonym: "ZIZIMIN 1" [MIM:607325]
exact_synonym: "ZIZIMIN1" [EntrezGene:23348]
xref_analog: UniProt:Q9BZ29
relationship: sequence_of IMR:0001477 ! DOCK9

[Term]
id: IMR:0001495
name: DOCK9_MOUSE
exact_synonym: "Cdc42 guanine nucleotide exchange factor zizimin-1" [UniProt:Q8BIK4]
exact_synonym: "D14Wsu89e" [MGI:106321, UniProt:Q8BIK4]
exact_synonym: "dedicator of cytokinesis 9" [MGI:106321]
exact_synonym: "Dedicator of cytokinesis protein 9" [UniProt:Q8BIK4]
exact_synonym: "Dock9" [MGI:106321, UniProt:Q8BIK4]
exact_synonym: "Kiaa1058" [UniProt:Q8BIK4]
exact_synonym: "Zizimin1" [MGI:106321]
xref_analog: UniProt:Q8BIK4
relationship: sequence_of IMR:0001477 ! DOCK9

[Term]
id: IMR:0001496
name: DOCK9_RAT
exact_synonym: "Cdc42 guanine nucleotide exchange factor zizimin-1" [UniProt:Q63603]
exact_synonym: "dedicator of cytokinesis 9" [RGD:629617]
exact_synonym: "Dedicator of cytokinesis protein 9" [UniProt:Q63603]
exact_synonym: "Dock9" [RGD:629617, UniProt:Q63603]
exact_synonym: "Protein TRG" [UniProt:Q63603]
exact_synonym: "Trg" [UniProt:Q63603]
xref_analog: UniProt:Q63603
relationship: sequence_of IMR:0001477 ! DOCK9

[Term]
id: IMR:0001497
name: DOC10_HUMAN
exact_synonym: "dedicator of cytokinesis 10" [EntrezGene:55619, HGNC:23479, MIM:611518]
exact_synonym: "Dedicator of cytokinesis protein 10" [UniProt:Q96BY6]
exact_synonym: "DKFZp781A1532" [EntrezGene:55619]
exact_synonym: "DOCK10" [EntrezGene:55619, HGNC:23479, MIM:611518, UniProt:Q96BY6]
exact_synonym: "DRIP2" [EntrezGene:55619]
exact_synonym: "KIAA0694" [HGNC:23479, MIM:611518, UniProt:Q96BY6]
exact_synonym: "Nbla10300" [EntrezGene:55619]
exact_synonym: "ZIZ3" [EntrezGene:55619, HGNC:23479, MIM:611518, UniProt:Q96BY6]
exact_synonym: "ZIZIMIN 3" [MIM:611518]
exact_synonym: "Zizimin-3" [UniProt:Q96BY6]
xref_analog: UniProt:Q96BY6
relationship: sequence_of IMR:0001478 ! DOCK10

[Term]
id: IMR:0001498
name: DOC10_MOUSE
exact_synonym: "dedicator of cytokinesis 10" [MGI:2146320]
exact_synonym: "Dedicator of cytokinesis protein 10" [UniProt:Q8BZN6]
exact_synonym: "Dock10" [UniProt:Q8BZN6, MGI:2146320]
exact_synonym: "Jr4" [MGI:2146320]
exact_synonym: "Jr5" [MGI:2146320]
exact_synonym: "Kiaa0694" [UniProt:Q8BZN6]
exact_synonym: "Ziz3" [UniProt:Q8BZN6]
exact_synonym: "ZIZ3" [MGI:2146320]
exact_synonym: "Zizimin-3" [UniProt:Q8BZN6]
exact_synonym: "Zizimin3" [MGI:2146320]
xref_analog: UniProt:Q8BZN6
relationship: sequence_of IMR:0001478 ! DOCK10

[Term]
id: IMR:0001499
name: RAC3_HUMAN
exact_synonym: "p21-Rac3" [UniProt:P60763]
exact_synonym: "RAC3" [EntrezGene:5881, MIM:602050, UniProt:P60763, HGNC:9803]
exact_synonym: "Ras-related C3 botulinum toxin substrate 3" [MIM:602050, UniProt:P60763]
exact_synonym: "ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)" [EntrezGene:5881, HGNC:9803]
exact_synonym: "RHO FAMILY, SMALL GTP-BINDING PROTEIN RAC3" [MIM:602050]
xref_analog: UniProt:P60763
relationship: sequence_of IMR:0001503 ! Rac3

[Term]
id: IMR:0001500
name: RAC1_RAT
exact_synonym: "p21-Rac1" [UniProt:Q6RUV5]
exact_synonym: "Rac1" [UniProt:Q6RUV5, RGD:619755]
exact_synonym: "Ras-related C3 botulinum toxin substrate 1" [UniProt:Q6RUV5]
exact_synonym: "ras-related C3 botulinum toxin substrate 1" [RGD:619755]
xref_analog: UniProt:Q6RUV5
relationship: sequence_of IMR:0001501 ! Rac1

[Term]
id: IMR:0001501
name: Rac1
is_a: IMR:0000297 ! Rac

[Term]
id: IMR:0001502
name: Rac2
is_a: IMR:0000297 ! Rac

[Term]
id: IMR:0001503
name: Rac3
is_a: IMR:0000297 ! Rac

[Term]
id: IMR:0001504
name: Rap1
is_a: IMR:0000294 ! Rap

[Term]
id: IMR:0001505
name: Rap1A
is_a: IMR:0001504 ! Rap1

[Term]
id: IMR:0001506
name: Rap1B
is_a: IMR:0001504 ! Rap1

[Term]
id: IMR:0001507
name: Rap2
is_a: IMR:0000294 ! Rap

[Term]
id: IMR:0001508
name: Rap2A
is_a: IMR:0001507 ! Rap2

[Term]
id: IMR:0001509
name: Rap2B
is_a: IMR:0001507 ! Rap2

[Term]
id: IMR:0001510
name: Rap2C
is_a: IMR:0001507 ! Rap2

[Term]
id: IMR:0001511
name: RAP1A_HUMAN
exact_synonym: "C21KG" [UniProt:P62834]
exact_synonym: "G-22K" [UniProt:P62834]
exact_synonym: "GTP-binding protein smg p21A" [UniProt:P62834]
exact_synonym: "KREV-1" [HGNC:9855, EntrezGene:5906]
exact_synonym: "KREV1" [EntrezGene:5906, UniProt:P62834]
exact_synonym: "RAP1" [EntrezGene:5906]
exact_synonym: "RAP1A" [HGNC:9855, EntrezGene:5906, UniProt:P62834]
exact_synonym: "RAP1A KREV1" [MIM:179520]
exact_synonym: "RAP1A, member of RAS oncogene family" [HGNC:9855, EntrezGene:5906]
exact_synonym: "RAS-RELATED PROTEIN 1A" [MIM:179520]
exact_synonym: "Ras-related protein Krev-1" [UniProt:P62834]
exact_synonym: "Ras-related protein Rap-1A" [UniProt:P62834]
exact_synonym: "SMGP21" [HGNC:9855, EntrezGene:5906]
xref_analog: UniProt:P62834
relationship: sequence_of IMR:0001505 ! Rap1A

[Term]
id: IMR:0001512
name: RAP1A_MOUSE
exact_synonym: "Krev-1" [UniProt:P62835, MGI:97852]
exact_synonym: "Rap1" [MGI:97852]
exact_synonym: "Rap1a" [UniProt:P62835, MGI:97852]
exact_synonym: "Ras-related protein Krev-1" [UniProt:P62835]
exact_synonym: "Ras-related protein Rap-1A" [UniProt:P62835]
exact_synonym: "RAS-related protein-1a" [MGI:97852]
xref_analog: UniProt:P62835
relationship: sequence_of IMR:0001505 ! Rap1A

[Term]
id: IMR:0001513
name: RAP1A_RAT
exact_synonym: "Krev1" [UniProt:P62836]
exact_synonym: "Rap1a" [UniProt:P62836, RGD:1359694]
exact_synonym: "RAP1A, member of RAS oncogene family" [RGD:1359694]
exact_synonym: "Ras-related protein Krev-1" [UniProt:P62836]
exact_synonym: "Ras-related protein Rap-1A" [UniProt:P62836]
xref_analog: UniProt:P62836
relationship: sequence_of IMR:0001505 ! Rap1A

[Term]
id: IMR:0001514
name: RAP1B_HUMAN
exact_synonym: "DKFZp586H0723" [EntrezGene:5908, HGNC:9857]
exact_synonym: "GTP-binding protein smg p21B" [UniProt:P61224]
exact_synonym: "K-REV" [EntrezGene:5908, HGNC:9857]
exact_synonym: "RAL1B" [EntrezGene:5908, HGNC:9857]
exact_synonym: "RAP1B" [UniProt:P61224, EntrezGene:5908, MIM:179530, HGNC:9857]
exact_synonym: "RAP1B, member of RAS oncogene family" [EntrezGene:5908, HGNC:9857]
exact_synonym: "Ras-related protein Rap-1b" [UniProt:P61224]
exact_synonym: "RAS-RELATED PROTEIN RAP1B" [MIM:179530]
xref_analog: UniProt:P61224
relationship: sequence_of IMR:0001506 ! Rap1B

[Term]
id: IMR:0001515
name: RAP1B_MOUSE
exact_synonym: "GTP-binding protein smg p21B" [UniProt:Q99JI6]
exact_synonym: "Rap1b" [MGI:894315, UniProt:Q99JI6]
exact_synonym: "RAS related protein 1b" [MGI:894315]
exact_synonym: "Ras-related protein Rap-1b" [UniProt:Q99JI6]
xref_analog: UniProt:Q99JI6
relationship: sequence_of IMR:0001506 ! Rap1B

[Term]
id: IMR:0001516
name: RAP1B_RAT
exact_synonym: "GTP-binding protein smg p21B" [UniProt:Q62636]
exact_synonym: "Rap1b" [RGD:620577, UniProt:Q62636]
exact_synonym: "RAP1B, member of RAS oncogene family" [RGD:620577]
exact_synonym: "Ras-related protein Rap-1b" [UniProt:Q62636]
xref_analog: UniProt:Q62636
relationship: sequence_of IMR:0001506 ! Rap1B

[Term]
id: IMR:0001517
name: RAP2A_HUMAN
exact_synonym: "K-REV" [HGNC:9861]
exact_synonym: "KREV" [MIM:179540]
exact_synonym: "RAP2" [MIM:179540]
exact_synonym: "RAP2A" [MIM:179540, UniProt:P10114, HGNC:9861]
exact_synonym: "RAP2A, member of RAS oncogene family" [HGNC:9861]
exact_synonym: "RAS-RELATED PROTEIN 2A" [MIM:179540]
exact_synonym: "Ras-related protein Rap-2a" [UniProt:P10114]
exact_synonym: "RbBP-30" [UniProt:P10114]
xref_analog: UniProt:P10114
relationship: sequence_of IMR:0001508 ! Rap2A

[Term]
id: IMR:0001518
name: RAP2A_MOUSE
exact_synonym: "Rap2a" [UniProt:Q80ZJ1, MGI:97855]
exact_synonym: "RAS related protein 2a" [MGI:97855]
exact_synonym: "Ras-related protein Rap-2a" [UniProt:Q80ZJ1]
xref_analog: UniProt:Q80ZJ1
relationship: sequence_of IMR:0001508 ! Rap2A

[Term]
id: IMR:0001519
name: RAP2B_HUMAN
exact_synonym: "MGC20484" [EntrezGene:5912]
exact_synonym: "RAP2B" [EntrezGene:5912, HGNC:9862, MIM:179541, UniProt:P61225]
exact_synonym: "RAP2B, member of RAS oncogene family" [EntrezGene:5912, HGNC:9862]
exact_synonym: "RAS-RELATED PROTEIN 2B" [MIM:179541]
exact_synonym: "Ras-related protein Rap-2b" [UniProt:P61225]
xref_analog: UniProt:P61225
relationship: sequence_of IMR:0001509 ! Rap2B

[Term]
id: IMR:0001520
name: RAP2B_MOUSE
exact_synonym: "Rap2b" [MGI:1921262, UniProt:P61226]
exact_synonym: "RAP2B, member of RAS oncogene family" [MGI:1921262]
exact_synonym: "Ras-related protein Rap-2b" [UniProt:P61226]
xref_analog: UniProt:P61226
relationship: sequence_of IMR:0001509 ! Rap2B

[Term]
id: IMR:0001521
name: RAP2B_RAT
exact_synonym: "Rap2b" [UniProt:P61227, RGD:620591]
exact_synonym: "RAP2B, member of RAS oncogene family" [RGD:620591]
exact_synonym: "Ras-related protein Rap-2b" [UniProt:P61227]
xref_analog: UniProt:P61227
relationship: sequence_of IMR:0001509 ! Rap2B

[Term]
id: IMR:0001522
name: RAP2C_HUMAN
exact_synonym: "DKFZp313B211" [HGNC:21165, EntrezGene:57826]
exact_synonym: "RAP2C" [HGNC:21165, EntrezGene:57826, UniProt:Q9Y3L5]
exact_synonym: "RAP2C, member of RAS oncogene family" [HGNC:21165, EntrezGene:57826]
exact_synonym: "Ras-related protein Rap-2c" [UniProt:Q9Y3L5]
xref_analog: UniProt:Q9Y3L5
relationship: sequence_of IMR:0001510 ! Rap2C

[Term]
id: IMR:0001523
name: RAP2C_MOUSE
exact_synonym: "Rap2c" [MGI:1919315, UniProt:Q8BU31]
exact_synonym: "RAP2C, member of RAS oncogene family" [MGI:1919315]
exact_synonym: "Ras-related protein Rap-2c" [UniProt:Q8BU31]
xref_analog: UniProt:Q8BU31
relationship: sequence_of IMR:0001510 ! Rap2C

[Term]
id: IMR:0001524
name: RALA_HUMAN
exact_synonym: "MGC48949" [EntrezGene:5898]
exact_synonym: "RAL" [UniProt:P11233, EntrezGene:5898, MIM:179550]
exact_synonym: "RALA" [UniProt:P11233, EntrezGene:5898, HGNC:9839, MIM:179550]
exact_synonym: "RAS-LIKE PROTEIN" [MIM:179550]
exact_synonym: "Ras-related protein Ral-A" [UniProt:P11233]
exact_synonym: "V-RAL SIMIAN LEUKEMIA VIRAL ONCOGENE HOMOLOG A" [MIM:179550]
exact_synonym: "v-ral simian leukemia viral oncogene homolog A (ras related)" [EntrezGene:5898, HGNC:9839]
xref_analog: UniProt:P11233
relationship: sequence_of IMR:0001527 ! RalA

[Term]
id: IMR:0001525
name: RALA_MOUSE
exact_synonym: "Ral" [UniProt:P63321, MGI:1927243]
exact_synonym: "Ral-a" [UniProt:P63321]
exact_synonym: "Rala" [UniProt:P63321, MGI:1927243]
exact_synonym: "Ras-related protein Ral-A" [UniProt:P63321]
exact_synonym: "Rasl1" [MGI:1927243]
exact_synonym: "v-ral simian leukemia viral oncogene homolog A (ras related)" [MGI:1927243]
xref_analog: UniProt:P63321
relationship: sequence_of IMR:0001527 ! RalA

[Term]
id: IMR:0001526
name: RALA_RAT
exact_synonym: "Ral" [UniProt:P63322]
exact_synonym: "Ral-a" [UniProt:P63322]
exact_synonym: "Rala" [RGD:619851, UniProt:P63322]
exact_synonym: "Ras-related protein Ral-A" [UniProt:P63322]
exact_synonym: "v-ral simian leukemia viral oncogene homolog A (ras related)" [RGD:619851]
xref_analog: UniProt:P63322
relationship: sequence_of IMR:0001527 ! RalA

[Term]
id: IMR:0001527
name: RalA
is_a: IMR:0000293 ! Ral

[Term]
id: IMR:0001528
name: RalB
is_a: IMR:0000293 ! Ral

[Term]
id: IMR:0001529
name: RALB_HUMAN
exact_synonym: "RALB" [EntrezGene:5899, UniProt:P11234, MIM:179551, HGNC:9840]
exact_synonym: "RAS-LIKE PROTEIN B" [MIM:179551]
exact_synonym: "Ras-related protein Ral-B" [UniProt:P11234]
exact_synonym: "V-RAL SIMIAN LEUKEMIA VIRAL ONCOGENE HOMOLOG B" [MIM:179551]
exact_synonym: "v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)" [EntrezGene:5899, HGNC:9840]
xref_analog: UniProt:P11234
relationship: sequence_of IMR:0001528 ! RalB

[Term]
id: IMR:0001530
name: RALB_MOUSE
exact_synonym: "Ralb" [MGI:1927244, UniProt:Q9JIW9]
exact_synonym: "Ras-related protein Ral-B" [UniProt:Q9JIW9]
exact_synonym: "v-ral simian leukemia viral oncogene homolog B (ras related)" [MGI:1927244]
xref_analog: UniProt:Q9JIW9
relationship: sequence_of IMR:0001528 ! RalB

[Term]
id: IMR:0001531
name: RALB_RAT
exact_synonym: "Ral-b" [UniProt:P36860]
exact_synonym: "Ralb" [UniProt:P36860, RGD:619852]
exact_synonym: "Ras-related protein Ral-B" [UniProt:P36860]
exact_synonym: "v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)" [RGD:619852]
xref_analog: UniProt:P36860
relationship: sequence_of IMR:0001528 ! RalB

[Term]
id: IMR:0001532
name: R-Ras1
is_a: IMR:0000292 ! R-Ras

[Term]
id: IMR:0001533
name: R-Ras2
is_a: IMR:0000292 ! R-Ras

[Term]
id: IMR:0001534
name: M-Ras
exact_synonym: "R-Ras3" []
is_a: IMR:0000292 ! R-Ras

[Term]
id: IMR:0001535
name: RRAS_HUMAN
exact_synonym: "ONCOGENE RRAS" [MIM:165090]
exact_synonym: "p23" [UniProt:P10301]
exact_synonym: "Ras-related protein R-Ras" [UniProt:P10301]
exact_synonym: "related RAS viral (r-ras) oncogene homolog" [HGNC:10447, EntrezGene:6237]
exact_synonym: "RELATED RAS VIRAL ONCOGENE HOMOLOG" [MIM:165090]
exact_synonym: "RRAS" [HGNC:10447, UniProt:P10301, EntrezGene:6237, MIM:165090]
xref_analog: UniProt:P10301
relationship: sequence_of IMR:0001532 ! R-Ras1

[Term]
id: IMR:0001536
name: RRAS_MOUSE
exact_synonym: "Harvey rat sarcoma oncogene, subgroup R" [MGI:98179]
exact_synonym: "p23" [UniProt:P10833]
exact_synonym: "Ras-related protein R-Ras" [UniProt:P10833]
exact_synonym: "Rras" [MGI:98179, UniProt:P10833]
xref_analog: UniProt:P10833
relationship: sequence_of IMR:0001532 ! R-Ras1

[Term]
id: IMR:0001537
name: RRAS2_HUMAN
exact_synonym: "ONCOGENE RRAS2" [MIM:600098]
exact_synonym: "Ras-like protein TC21" [UniProt:P62070]
exact_synonym: "Ras-related protein R-Ras2" [UniProt:P62070]
exact_synonym: "related RAS viral (r-ras) oncogene homolog 2" [EntrezGene:22800, HGNC:17271]
exact_synonym: "RELATED RAS VIRAL ONCOGENE HOMOLOG 2" [MIM:600098]
exact_synonym: "RRAS2" [EntrezGene:22800, MIM:600098, HGNC:17271, UniProt:P62070]
exact_synonym: "TC21" [EntrezGene:22800, MIM:600098, HGNC:17271, UniProt:P62070]
exact_synonym: "Teratocarcinoma oncogene" [UniProt:P62070]
exact_synonym: "TERATOCARCINOMA ONCOGENE TC21" [MIM:600098]
xref_analog: UniProt:P62070
relationship: sequence_of IMR:0001533 ! R-Ras2

[Term]
id: IMR:0001538
name: RRAS2_MOUSE
exact_synonym: "Ras-related protein R-Ras2" [UniProt:P62071]
exact_synonym: "related RAS viral (r-ras) oncogene homolog 2" [MGI:1914172]
exact_synonym: "Rras2" [UniProt:P62071, MGI:1914172]
exact_synonym: "TC21" [MGI:1914172]
xref_analog: UniProt:P62071
relationship: sequence_of IMR:0001533 ! R-Ras2

[Term]
id: IMR:0001539
name: RASM_HUMAN
exact_synonym: "FLJ42964" [EntrezGene:22808]
exact_synonym: "M-RAs" [EntrezGene:22808, HGNC:7227]
exact_synonym: "MRAS" [EntrezGene:22808, MIM:608435, UniProt:O14807, HGNC:7227]
exact_synonym: "muscle RAS oncogene homolog" [EntrezGene:22808, HGNC:7227]
exact_synonym: "MUSCLE RAS VIRAL ONCOGENE HOMOLOG" [MIM:608435]
exact_synonym: "R-RAS3" [EntrezGene:22808, HGNC:7227]
exact_synonym: "Ras-related protein M-Ras" [UniProt:O14807]
exact_synonym: "Ras-related protein R-Ras3" [UniProt:O14807]
exact_synonym: "RELATED RAS VIRAL ONCOGENE HOMOLOG 3" [MIM:608435]
exact_synonym: "RRAS3" [EntrezGene:22808, MIM:608435, UniProt:O14807, HGNC:7227]
xref_analog: UniProt:O14807
relationship: sequence_of IMR:0001534 ! M-Ras

[Term]
id: IMR:0001540
name: RASM_MOUSE
exact_synonym: "Mras" [MGI:1100856, UniProt:O08989]
exact_synonym: "Muscle and microspikes Ras" [UniProt:O08989]
exact_synonym: "muscle and microspikes RAS" [MGI:1100856]
exact_synonym: "Ras-related protein M-Ras" [UniProt:O08989]
exact_synonym: "Ras-related protein R-Ras3" [UniProt:O08989]
exact_synonym: "X-Ras" [UniProt:O08989]
exact_synonym: "Xras" [UniProt:O08989]
xref_analog: UniProt:O08989
relationship: sequence_of IMR:0001534 ! M-Ras

[Term]
id: IMR:0001541
name: RASM_RAT
exact_synonym: "Mras" [UniProt:P97538, RGD:3111]
exact_synonym: "muscle RAS oncogene homolog" [RGD:3111]
exact_synonym: "Ras-related protein M-Ras" [UniProt:P97538]
exact_synonym: "Ras-related protein R-Ras3" [UniProt:P97538]
exact_synonym: "Rras3" [UniProt:P97538]
xref_analog: UniProt:P97538
relationship: sequence_of IMR:0001534 ! M-Ras

[Term]
id: IMR:0001542
name: RAN_HUMAN
exact_synonym: "Androgen receptor-associated protein 24" [UniProt:P62826]
exact_synonym: "ARA24" [UniProt:P62826, EntrezGene:5901, HGNC:9846]
exact_synonym: "Gsp1" [EntrezGene:5901, HGNC:9846]
exact_synonym: "GTP-binding nuclear protein Ran" [UniProt:P62826]
exact_synonym: "GTPase Ran" [UniProt:P62826]
exact_synonym: "RAN" [UniProt:P62826, EntrezGene:5901, MIM:601179, HGNC:9846]
exact_synonym: "RAN, member RAS oncogene family" [EntrezGene:5901, HGNC:9846]
exact_synonym: "Ras-like protein TC4" [UniProt:P62826]
exact_synonym: "Ras-related nuclear protein" [UniProt:P62826, MIM:601179]
exact_synonym: "TC4" [EntrezGene:5901, HGNC:9846]
xref_analog: UniProt:P62826
relationship: sequence_of IMR:0000300 ! Ran

[Term]
id: IMR:0001543
name: RAN_MOUSE
exact_synonym: "GTP-binding nuclear protein Ran" [UniProt:P62827]
exact_synonym: "GTPase Ran" [UniProt:P62827]
exact_synonym: "Ran" [MGI:1333112, UniProt:P62827]
exact_synonym: "RAN, member RAS oncogene family" [MGI:1333112]
exact_synonym: "Ras-like protein TC4" [UniProt:P62827]
exact_synonym: "Ras-related nuclear protein" [UniProt:P62827]
exact_synonym: "Rasl2-8" [UniProt:P62827]
xref_analog: UniProt:P62827
relationship: sequence_of IMR:0000300 ! Ran

[Term]
id: IMR:0001544
name: NTF2_HUMAN
exact_synonym: "NTF-2" [UniProt:P61970]
exact_synonym: "NTF2" [EntrezGene:10204, MIM:605813, HGNC:13722, UniProt:P61970]
exact_synonym: "Nuclear transport factor 2" [MIM:605813, UniProt:P61970]
exact_synonym: "nuclear transport factor 2" [EntrezGene:10204, HGNC:13722]
exact_synonym: "NUTF2" [EntrezGene:10204, HGNC:13722, UniProt:P61970]
exact_synonym: "Placental protein 15" [MIM:605813, UniProt:P61970]
exact_synonym: "PP15" [EntrezGene:10204, MIM:605813, HGNC:13722, UniProt:P61970]
xref_analog: UniProt:P61970
relationship: sequence_of IMR:0100283 ! NTF2

[Term]
id: IMR:0001545
name: NTF2_MOUSE
exact_synonym: "NTF-2" [UniProt:P61971]
exact_synonym: "Ntf2" [UniProt:P61971, MGI:1915301]
exact_synonym: "Nuclear transport factor 2" [UniProt:P61971]
exact_synonym: "nuclear transport factor 2" [MGI:1915301]
exact_synonym: "Nutf2" [UniProt:P61971, MGI:1915301]
exact_synonym: "PP15" [MGI:1915301]
xref_analog: UniProt:P61971
relationship: sequence_of IMR:0100283 ! NTF2

[Term]
id: IMR:0001546
name: NTF2_RAT
exact_synonym: "NTF-2" [UniProt:P61972]
exact_synonym: "Ntf2" [UniProt:P61972]
exact_synonym: "Nuclear transport factor 2" [UniProt:P61972]
exact_synonym: "nuclear transport factor 2" [RGD:1359213]
exact_synonym: "Nutf2" [UniProt:P61972, RGD:1359213]
xref_analog: UniProt:P61972
relationship: sequence_of IMR:0100283 ! NTF2

[Term]
id: IMR:0001547
name: Rab1A
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001548
name: RAB1A_HUMAN
exact_synonym: "DKFZp564B163" [EntrezGene:5861]
exact_synonym: "RAB1" [EntrezGene:5861, MIM:179508, UniProt:P62820]
exact_synonym: "RAB1A" [HGNC:9758, EntrezGene:5861, MIM:179508, UniProt:P62820]
exact_synonym: "RAB1A, member RAS oncogene family" [HGNC:9758, EntrezGene:5861]
exact_synonym: "RAS-ASSOCIATED PROTEIN RAB1" [MIM:179508]
exact_synonym: "Ras-related protein Rab-1A" [UniProt:P62820]
exact_synonym: "YPT1" [HGNC:9758, EntrezGene:5861]
exact_synonym: "YPT1-related protein" [UniProt:P62820]
xref_analog: UniProt:P62820
relationship: sequence_of IMR:0001547 ! Rab1A

[Term]
id: IMR:0001549
name: Rab1B
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001550
name: RAB1B_HUMAN
exact_synonym: "RAB1B" [MIM:612565, UniProt:Q9H0U4, EntrezGene:81876, HGNC:18370]
exact_synonym: "RAB1B, member RAS oncogene family" [EntrezGene:81876, HGNC:18370]
exact_synonym: "RAS-ASSOCIATED PROTEIN RAB1B" [MIM:612565]
exact_synonym: "Ras-related protein Rab-1B" [UniProt:Q9H0U4]
xref_analog: UniProt:Q9H0U4
relationship: sequence_of IMR:0001549 ! Rab1B

[Term]
id: IMR:0001551
name: RAB1B_MOUSE
exact_synonym: "Rab1b" [MGI:1923558, UniProt:Q9D1G1]
exact_synonym: "RAB1B, member RAS oncogene family" [MGI:1923558]
exact_synonym: "Ras-related protein Rab-1B" [UniProt:Q9D1G1]
xref_analog: UniProt:Q9D1G1
relationship: sequence_of IMR:0001549 ! Rab1B

[Term]
id: IMR:0001552
name: Rab2A
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001553
name: Rab2B
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001554
name: RAB2B_HUMAN
exact_synonym: "FLJ14824" [HGNC:20246]
exact_synonym: "RAB2B" [UniProt:Q8WUD1, MIM:607466, HGNC:20246]
exact_synonym: "RAB2B, member RAS oncogene family" [HGNC:20246]
exact_synonym: "RAS-ASSOCIATED PROTEIN RAB2B" [MIM:607466]
exact_synonym: "Ras-related protein Rab-2B" [UniProt:Q8WUD1]
xref_analog: UniProt:Q8WUD1
relationship: sequence_of IMR:0001553 ! Rab2B

[Term]
id: IMR:0001555
name: RAB2B_MOUSE
exact_synonym: "Rab2b" [MGI:1923588, UniProt:P59279]
exact_synonym: "RAB2B, member RAS oncogene family" [MGI:1923588]
exact_synonym: "Ras-related protein Rab-2B" [UniProt:P59279]
xref_analog: UniProt:P59279
relationship: sequence_of IMR:0001553 ! Rab2B

[Term]
id: IMR:0001556
name: Rab3A
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001557
name: RAB3A_MOUSE
exact_synonym: "Rab3a" [MGI:97843, UniProt:P63011]
exact_synonym: "RAB3A, member RAS oncogene family" [MGI:97843]
exact_synonym: "Ras-related protein Rab-3A" [UniProt:P63011]
xref_analog: UniProt:P63011
relationship: sequence_of IMR:0001556 ! Rab3A

[Term]
id: IMR:0001558
name: Rab3B
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001559
name: RAB3B_MOUSE
exact_synonym: "Rab3b" [UniProt:Q9CZT8, MGI:1917158]
exact_synonym: "RAB3B, member RAS oncogene family" [MGI:1917158]
exact_synonym: "Ras-related protein Rab-3B" [UniProt:Q9CZT8]
xref_analog: UniProt:Q9CZT8
relationship: sequence_of IMR:0001558 ! Rab3B

[Term]
id: IMR:0001560
name: Rab3C
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001561
name: RAB3C_HUMAN
exact_synonym: "RAB3C" [HGNC:30269, MIM:612829, UniProt:Q96E17, EntrezGene:115827]
exact_synonym: "RAB3C, member RAS oncogene family" [HGNC:30269, EntrezGene:115827]
exact_synonym: "RAS-ASSOCIATED PROTEIN RAB3C" [MIM:612829]
exact_synonym: "Ras-related protein Rab-3C" [UniProt:Q96E17]
xref_analog: UniProt:Q96E17
relationship: sequence_of IMR:0001560 ! Rab3C

[Term]
id: IMR:0001562
name: RAB3C_MOUSE
exact_synonym: "Rab3c" [MGI:1914545, UniProt:P62823]
exact_synonym: "RAB3C, member RAS oncogene family" [MGI:1914545]
exact_synonym: "Ras-related protein Rab-3C" [UniProt:P62823]
xref_analog: UniProt:P62823
relationship: sequence_of IMR:0001560 ! Rab3C

[Term]
id: IMR:0001563
name: Rab3D
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001564
name: Rab4A
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001565
name: Rab4B
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001566
name: RAB4B_MOUSE
exact_synonym: "Rab4" [UniProt:Q91ZR1]
exact_synonym: "Rab4b" [MGI:105071, UniProt:Q91ZR1]
exact_synonym: "RAB4B, member RAS oncogene family" [MGI:105071]
exact_synonym: "Ras-related protein Rab-4B" [UniProt:Q91ZR1]
xref_analog: UniProt:Q91ZR1
relationship: sequence_of IMR:0001565 ! Rab4B

[Term]
id: IMR:0001567
name: Rab5A
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001568
name: Rab5B
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001569
name: Rab5C
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001570
name: RAB5A_MOUSE
exact_synonym: "Rab5a" [UniProt:Q9CQD1, MGI:105926]
exact_synonym: "RAB5A, member RAS oncogene family" [MGI:105926]
exact_synonym: "Ras-related protein Rab-5A" [UniProt:Q9CQD1]
xref_analog: UniProt:Q9CQD1
relationship: sequence_of IMR:0001567 ! Rab5A

[Term]
id: IMR:0001571
name: RAB5B_HUMAN
exact_synonym: "RAB5B" [EntrezGene:5869, UniProt:P61020, MIM:179514, HGNC:9784]
exact_synonym: "RAB5B, member RAS oncogene family" [EntrezGene:5869, HGNC:9784]
exact_synonym: "RAS-ASSOCIATED PROTEIN RAB5B" [MIM:179514]
exact_synonym: "Ras-related protein Rab-5B" [UniProt:P61020]
xref_analog: UniProt:P61020
relationship: sequence_of IMR:0001568 ! Rab5B

[Term]
id: IMR:0001572
name: Rab6A
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001573
name: Rab6B
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001574
name: Rab6C
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001575
name: RAB6B_MOUSE
exact_synonym: "D9Bwg0185e" [UniProt:P61294, MGI:107283]
exact_synonym: "Rab6b" [UniProt:P61294, MGI:107283]
exact_synonym: "RAB6B, member RAS oncogene family" [MGI:107283]
exact_synonym: "Ras-related protein Rab-6B" [UniProt:P61294]
xref_analog: UniProt:P61294
relationship: sequence_of IMR:0001573 ! Rab6B

[Term]
id: IMR:0001576
name: RAB6C_HUMAN
exact_synonym: "Rab6-like protein WTH3" [UniProt:Q9H0N0]
exact_synonym: "RAB6C" [HGNC:16525, UniProt:Q9H0N0, MIM:612909, EntrezGene:84084]
exact_synonym: "RAB6C, member RAS oncogene family" [HGNC:16525, EntrezGene:84084]
exact_synonym: "RAS-ASSOCIATED PROTEIN RAB6C" [MIM:612909]
exact_synonym: "Ras-related protein Rab-6C" [UniProt:Q9H0N0]
exact_synonym: "WTH3" [HGNC:16525, UniProt:Q9H0N0, MIM:612909, EntrezGene:84084]
xref_analog: UniProt:Q9H0N0
relationship: sequence_of IMR:0001574 ! Rab6C

[Term]
id: IMR:0001577
name: Rab7
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001578
name: Rab7L
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001579
name: Rab8A
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001580
name: Rab8B
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001581
name: Rab9A
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001582
name: Rab9B
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001583
name: RAB8B_MOUSE
exact_synonym: "Rab8b" [MGI:2442982, UniProt:P61028]
exact_synonym: "RAB8B, member RAS oncogene family" [MGI:2442982]
exact_synonym: "Ras-related protein Rab-8B" [UniProt:P61028]
xref_analog: UniProt:P61028
relationship: sequence_of IMR:0001580 ! Rab8B

[Term]
id: IMR:0001584
name: RAB9A_MOUSE
exact_synonym: "Rab9" [MGI:1890695, UniProt:Q9R0M6]
exact_synonym: "RAB9, member RAS oncogene family" [MGI:1890695]
exact_synonym: "Rab9a" [UniProt:Q9R0M6]
exact_synonym: "Ras-related protein Rab-9A" [UniProt:Q9R0M6]
exact_synonym: "Sid 99" [UniProt:Q9R0M6]
exact_synonym: "SID 99" [MGI:1890695]
exact_synonym: "Sid99" [UniProt:Q9R0M6]
xref_analog: UniProt:Q9R0M6
relationship: sequence_of IMR:0001581 ! Rab9A

[Term]
id: IMR:0001585
name: RAB9B_MOUSE
exact_synonym: "Rab9b" [UniProt:Q8BHH2, MGI:2442454]
exact_synonym: "RAB9B, member RAS oncogene family" [MGI:2442454]
exact_synonym: "Ras-related protein Rab-9B" [UniProt:Q8BHH2]
xref_analog: UniProt:Q8BHH2
relationship: sequence_of IMR:0001582 ! Rab9B

[Term]
id: IMR:0001586
name: Rab10
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001587
name: RAB10_HUMAN
exact_synonym: "RAB10" [UniProt:P61026, MIM:612672, HGNC:9759, EntrezGene:10890]
exact_synonym: "RAB10, member RAS oncogene family" [HGNC:9759, EntrezGene:10890]
exact_synonym: "RAS-ASSOCIATED PROTEIN RAB10" [MIM:612672]
exact_synonym: "Ras-related protein Rab-10" [UniProt:P61026]
xref_analog: UniProt:P61026
relationship: sequence_of IMR:0001586 ! Rab10

[Term]
id: IMR:0001588
name: Rab11A
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001589
name: Rab11B
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001590
name: RB11A_HUMAN
exact_synonym: "MGC1490" [EntrezGene:8766]
exact_synonym: "Rab-11" [UniProt:P62491]
exact_synonym: "RAB11" [UniProt:P62491]
exact_synonym: "RAB11A" [EntrezGene:8766, HGNC:9760, MIM:605570, UniProt:P62491]
exact_synonym: "RAB11A, member RAS oncogene family" [EntrezGene:8766, HGNC:9760]
exact_synonym: "RAS-ASSOCIATED PROTEIN RAB11A" [MIM:605570]
exact_synonym: "Ras-related protein Rab-11A" [UniProt:P62491]
exact_synonym: "YL8" [EntrezGene:8766, HGNC:9760, UniProt:P62491]
xref_analog: UniProt:P62491
relationship: sequence_of IMR:0001588 ! Rab11A

[Term]
id: IMR:0001591
name: RB11A_MOUSE
exact_synonym: "Rab-11" [UniProt:P62492]
exact_synonym: "Rab11" [UniProt:P62492]
exact_synonym: "Rab11a" [MGI:1858202, UniProt:P62492]
exact_synonym: "RAB11a, member RAS oncogene family" [MGI:1858202]
exact_synonym: "Ras-related protein Rab-11A" [UniProt:P62492]
xref_analog: UniProt:P62492
relationship: sequence_of IMR:0001588 ! Rab11A

[Term]
id: IMR:0001592
name: Rab12
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001593
name: Rab13
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001594
name: RAB13_MOUSE
exact_synonym: "Rab13" [UniProt:Q9DD03, MGI:1927232]
exact_synonym: "RAB13, member RAS oncogene family" [MGI:1927232]
exact_synonym: "Ras-related protein Rab-13" [UniProt:Q9DD03]
xref_analog: UniProt:Q9DD03
relationship: sequence_of IMR:0001593 ! Rab13

[Term]
id: IMR:0001595
name: Rab14
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001596
name: RAB14_HUMAN
exact_synonym: "FBP" [HGNC:16524, EntrezGene:51552]
exact_synonym: "RAB-14" [HGNC:16524, EntrezGene:51552]
exact_synonym: "RAB14" [HGNC:16524, MIM:612673, UniProt:P61106, EntrezGene:51552]
exact_synonym: "RAB14, member RAS oncogene family" [HGNC:16524, EntrezGene:51552]
exact_synonym: "RAS-ASSOCIATED PROTEIN RAB14" [MIM:612673]
exact_synonym: "Ras-related protein Rab-14" [UniProt:P61106]
xref_analog: UniProt:P61106
relationship: sequence_of IMR:0001595 ! Rab14

[Term]
id: IMR:0001597
name: RAB14_MOUSE
exact_synonym: "Rab14" [MGI:1915615, UniProt:Q91V41]
exact_synonym: "RAB14, member RAS oncogene family" [MGI:1915615]
exact_synonym: "Ras-related protein Rab-14" [UniProt:Q91V41]
xref_analog: UniProt:Q91V41
relationship: sequence_of IMR:0001595 ! Rab14

[Term]
id: IMR:0001598
name: Rab15
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001599
name: RAB15_HUMAN
exact_synonym: "RAB15" [EntrezGene:376267, HGNC:20150, UniProt:P59190]
exact_synonym: "RAB15, member RAS onocogene family" [EntrezGene:376267, HGNC:20150]
exact_synonym: "Ras-related protein Rab-15" [UniProt:P59190]
xref_analog: UniProt:P59190
relationship: sequence_of IMR:0001598 ! Rab15

[Term]
id: IMR:0001600
name: RAB15_MOUSE
exact_synonym: "Rab15" [UniProt:Q8K386, MGI:1916865]
exact_synonym: "RAB15, member RAS oncogene family" [MGI:1916865]
exact_synonym: "Ras-related protein Rab-15" [UniProt:Q8K386]
xref_analog: UniProt:Q8K386
relationship: sequence_of IMR:0001598 ! Rab15

[Term]
id: IMR:0001601
name: Rab17
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001602
name: Rab18
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001603
name: Rab19
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001604
name: Rab20
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001605
name: Rab21
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001606
name: Rab22A
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001607
name: Rab23
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001608
name: Rab24
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001609
name: RAB24_HUMAN
exact_synonym: "RAB24" [EntrezGene:53917, HGNC:9765, MIM:612415, UniProt:Q969Q5]
exact_synonym: "RAB24, member RAS oncogene family" [EntrezGene:53917, HGNC:9765]
exact_synonym: "RAS-ASSOCIATED PROTEIN 24" [MIM:612415]
exact_synonym: "Ras-related protein Rab-24" [UniProt:Q969Q5]
xref_analog: UniProt:Q969Q5
relationship: sequence_of IMR:0001608 ! Rab24

[Term]
id: IMR:0001610
name: Rab25
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001611
name: Rab26
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001612
name: Rab27A
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001613
name: Rab27B
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001614
name: Rab28
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001615
name: RAB28_MOUSE
exact_synonym: "Rab28" [MGI:1917285, UniProt:Q99KL7]
exact_synonym: "RAB28, member RAS oncogene family" [MGI:1917285]
exact_synonym: "Ras-related protein Rab-28" [UniProt:Q99KL7]
xref_analog: UniProt:Q99KL7
relationship: sequence_of IMR:0001614 ! Rab28

[Term]
id: IMR:0001616
name: Rab30
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001617
name: Rab31
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001618
name: Rab32
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001619
name: RAB30_MOUSE
exact_synonym: "Rab30" [MGI:1923235, UniProt:Q923S9]
exact_synonym: "RAB30, member RAS oncogene family" [MGI:1923235]
exact_synonym: "Ras-related protein Rab-30" [UniProt:Q923S9]
exact_synonym: "Rsb30" [UniProt:Q923S9]
xref_analog: UniProt:Q923S9
relationship: sequence_of IMR:0001616 ! Rab30

[Term]
id: IMR:0001620
name: RAB31_MOUSE
exact_synonym: "Rab31" [UniProt:Q921E2, MGI:1914603]
exact_synonym: "RAB31, member RAS oncogene family" [MGI:1914603]
exact_synonym: "Ras-related protein Rab-31" [UniProt:Q921E2]
xref_analog: UniProt:Q921E2
relationship: sequence_of IMR:0001617 ! Rab31

[Term]
id: IMR:0001621
name: RAB31_RAT
exact_synonym: "GTP-binding protein Rab0" [UniProt:Q6GQP4]
exact_synonym: "Rab31" [RGD:628598, UniProt:Q6GQP4]
exact_synonym: "RAB31, member RAS oncogene family" [RGD:628598]
exact_synonym: "Ras-related protein Rab-31" [UniProt:Q6GQP4]
xref_analog: UniProt:Q6GQP4
relationship: sequence_of IMR:0001617 ! Rab31

[Term]
id: IMR:0001622
name: RAB32_MOUSE
exact_synonym: "Rab32" [UniProt:Q9CZE3, MGI:1915094]
exact_synonym: "RAB32, member RAS oncogene family" [MGI:1915094]
exact_synonym: "Ras-related protein Rab-32" [UniProt:Q9CZE3]
xref_analog: UniProt:Q9CZE3
relationship: sequence_of IMR:0001618 ! Rab32

[Term]
id: IMR:0001623
name: Rab33A
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001624
name: Rab33B
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001625
name: Rab34
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001626
name: Rab35
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001627
name: Rab36
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001628
name: Rab37
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001629
name: Rab38
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001630
name: RAB35_MOUSE
exact_synonym: "H-ray" [MGI:1924657]
exact_synonym: "RAB1C" [MGI:1924657]
exact_synonym: "Rab35" [UniProt:Q6PHN9, MGI:1924657]
exact_synonym: "RAB35, member RAS oncogene family" [MGI:1924657]
exact_synonym: "Ras-related protein Rab-35" [UniProt:Q6PHN9]
xref_analog: UniProt:Q6PHN9
relationship: sequence_of IMR:0001626 ! Rab35

[Term]
id: IMR:0001631
name: RAB38_MOUSE
exact_synonym: "Rab38" [UniProt:Q8QZZ8, MGI:1919683]
exact_synonym: "RAB38, member of RAS oncogene family" [MGI:1919683]
exact_synonym: "Ras-related protein Rab-38" [UniProt:Q8QZZ8]
xref_analog: UniProt:Q8QZZ8
relationship: sequence_of IMR:0001629 ! Rab38

[Term]
id: IMR:0001632
name: Rab39A
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001633
name: Rab39B
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001634
name: Rab40A
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001635
name: Rab40B
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001636
name: Rab40C
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001637
name: RB39A_MOUSE
exact_synonym: "Rab-39" [UniProt:Q8BHD0]
exact_synonym: "Rab39" [UniProt:Q8BHD0, MGI:2442855]
exact_synonym: "RAB39, member RAS oncogene family" [MGI:2442855]
exact_synonym: "Rab39a" [UniProt:Q8BHD0, MGI:2442855]
exact_synonym: "Ras-related protein Rab-39A" [UniProt:Q8BHD0]
xref_analog: UniProt:Q8BHD0
relationship: sequence_of IMR:0001632 ! Rab39A

[Term]
id: IMR:0001638
name: RB39B_HUMAN
exact_synonym: "MRX72" [EntrezGene:116442]
exact_synonym: "RAB39B" [MIM:300774, EntrezGene:116442, UniProt:Q96DA2, HGNC:16499]
exact_synonym: "RAB39B, member RAS oncogene family" [EntrezGene:116442, HGNC:16499]
exact_synonym: "RAS-ASSOCIATED PROTEIN RAB39B" [MIM:300774]
exact_synonym: "Ras-related protein Rab-39B" [UniProt:Q96DA2]
xref_analog: UniProt:Q96DA2
relationship: sequence_of IMR:0001633 ! Rab39B

[Term]
id: IMR:0001639
name: RB39B_MOUSE
exact_synonym: "Rab39b" [UniProt:Q8BHC1, MGI:1915040]
exact_synonym: "RAB39B, member RAS oncogene family" [MGI:1915040]
exact_synonym: "Ras-related protein Rab-39B" [UniProt:Q8BHC1]
xref_analog: UniProt:Q8BHC1
relationship: sequence_of IMR:0001633 ! Rab39B

[Term]
id: IMR:0001640
name: RB40A_HUMAN
exact_synonym: "MGC142061" [EntrezGene:142684]
exact_synonym: "Protein Rar-2" [UniProt:Q8WXH6]
exact_synonym: "RAB40A" [EntrezGene:142684, HGNC:18283, UniProt:Q8WXH6]
exact_synonym: "RAB40A, member RAS oncogene family" [EntrezGene:142684, HGNC:18283]
exact_synonym: "Rar-2" [HGNC:18283]
exact_synonym: "RAR2" [EntrezGene:142684]
exact_synonym: "RAR2A" [EntrezGene:142684, HGNC:18283]
exact_synonym: "Ras-related protein Rab-40A" [UniProt:Q8WXH6]
exact_synonym: "SOCS box-containing protein RAR2A" [UniProt:Q8WXH6]
xref_analog: UniProt:Q8WXH6
relationship: sequence_of IMR:0001634 ! Rab40A

[Term]
id: IMR:0001641
name: RB40B_HUMAN
exact_synonym: "FLJ42385" [EntrezGene:10966]
exact_synonym: "Protein Rar" [UniProt:Q12829]
exact_synonym: "RAB40B" [EntrezGene:10966, UniProt:Q12829, HGNC:18284]
exact_synonym: "RAB40B, member RAS oncogene family" [EntrezGene:10966, HGNC:18284]
exact_synonym: "RAR" [EntrezGene:10966, HGNC:18284]
exact_synonym: "Ras-related protein Rab-40B" [UniProt:Q12829]
exact_synonym: "SEC4L" [EntrezGene:10966, UniProt:Q12829, HGNC:18284]
exact_synonym: "SOCS box-containing protein RAR" [UniProt:Q12829]
xref_analog: UniProt:Q12829
relationship: sequence_of IMR:0001635 ! Rab40B

[Term]
id: IMR:0001642
name: RB40B_MOUSE
exact_synonym: "Rab40b" [UniProt:Q8VHP8, MGI:2183451]
exact_synonym: "Rab40b, member RAS oncogene family" [MGI:2183451]
exact_synonym: "rar" [MGI:2183451]
exact_synonym: "Ras-related protein Rab-40B" [UniProt:Q8VHP8]
exact_synonym: "SOCS box-containing protein RAR" [UniProt:Q8VHP8]
xref_analog: UniProt:Q8VHP8
relationship: sequence_of IMR:0001635 ! Rab40B

[Term]
id: IMR:0001643
name: RB40C_HUMAN
exact_synonym: "RAB40C" [EntrezGene:57799, HGNC:18285, UniProt:Q96S21]
exact_synonym: "RAB40C, member RAS oncogene family" [EntrezGene:57799, HGNC:18285]
exact_synonym: "Rar-like protein" [UniProt:Q96S21]
exact_synonym: "RARL" [EntrezGene:57799, HGNC:18285, UniProt:Q96S21]
exact_synonym: "Ras-like protein family member 8C" [UniProt:Q96S21]
exact_synonym: "Ras-related protein Rab-40C" [UniProt:Q96S21]
exact_synonym: "RASL8C" [EntrezGene:57799, UniProt:Q96S21]
exact_synonym: "SOCS box-containing protein RAR3" [UniProt:Q96S21]
xref_analog: UniProt:Q96S21
relationship: sequence_of IMR:0001636 ! Rab40C

[Term]
id: IMR:0001644
name: RB40C_MOUSE
exact_synonym: "Rab40c" [MGI:2183454, UniProt:Q8VHQ4]
exact_synonym: "Rab40c, member RAS oncogene family" [MGI:2183454]
exact_synonym: "RAR3" [MGI:2183454]
exact_synonym: "Ras-related protein Rab-40C" [UniProt:Q8VHQ4]
exact_synonym: "SOCS box-containing protein RAR3" [UniProt:Q8VHQ4]
xref_analog: UniProt:Q8VHQ4
relationship: sequence_of IMR:0001636 ! Rab40C

[Term]
id: IMR:0001645
name: RABL2A
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001646
name: RABL2B
is_a: IMR:0000299 ! Rab

[Term]
id: IMR:0001647
name: caveolin-1
exact_synonym: "Cav-1" []
is_a: IMR:0000515 ! caveolin

[Term]
id: IMR:0001648
name: caveolin-2
exact_synonym: "Cav-2" []
is_a: IMR:0000515 ! caveolin

[Term]
id: IMR:0001649
name: caveolin-3
exact_synonym: "Cav-3" []
is_a: IMR:0000515 ! caveolin

[Term]
id: IMR:0001650
name: inositol phospholipid
exact_synonym: "phosphoinositide" []
is_a: IMR:0001384 ! glycerophospholipid

[Term]
id: IMR:0001651
name: phosphatidylinositol
exact_synonym: "inositol phosphoglyceride" []
exact_synonym: "monophosphoinositide" []
exact_synonym: "MPI" []
exact_synonym: "phosphoinositide" []
exact_synonym: "PI" []
xref_analog: KEGG:C00626
is_a: IMR:0001650 ! inositol phospholipid

[Term]
id: IMR:0001652
name: VRAP
exact_synonym: "VEGFR-associated protein" []
is_a: IMR:0000333 ! adaptor protein

[Term]
id: IMR:0001653
name: SH22A_HUMAN
exact_synonym: "F2771" [EntrezGene:9047, HGNC:10821]
exact_synonym: "SCAP" [EntrezGene:9047, UniProt:Q9NP31]
exact_synonym: "SH2 domain containing 2A" [EntrezGene:9047, HGNC:10821]
exact_synonym: "SH2 DOMAIN PROTEIN 2A" [MIM:604514]
exact_synonym: "SH2 domain-containing adapter protein" [UniProt:Q9NP31]
exact_synonym: "SH2 domain-containing protein 2A" [UniProt:Q9NP31]
exact_synonym: "SH2D2A" [EntrezGene:9047, UniProt:Q9NP31, MIM:604514, HGNC:10821]
exact_synonym: "T cell-specific adapter protein" [UniProt:Q9NP31]
exact_synonym: "T-CELL SH2 DOMAIN-CONTAINING ADAPTOR PROTEIN" [MIM:604514]
exact_synonym: "TSAd" [UniProt:Q9NP31, MIM:604514, HGNC:10821]
exact_synonym: "TSAD" [EntrezGene:9047, UniProt:Q9NP31]
exact_synonym: "VEGF receptor-associated protein" [UniProt:Q9NP31]
exact_synonym: "VRAP" [EntrezGene:9047, UniProt:Q9NP31]
xref_analog: UniProt:Q9NP31
relationship: sequence_of IMR:0001652 ! VRAP

[Term]
id: IMR:0001654
name: SH22A_MOUSE
exact_synonym: "Lad" [MGI:1351596, UniProt:Q9QXK9]
exact_synonym: "Lck-associated adapter protein" [MGI:1351596, UniProt:Q9QXK9]
exact_synonym: "Ribp" [UniProt:Q9QXK9]
exact_synonym: "RIBP" [MGI:1351596]
exact_synonym: "Rlk/Itk-binding protein" [MGI:1351596, UniProt:Q9QXK9]
exact_synonym: "SH2 domain protein 2A" [MGI:1351596]
exact_synonym: "SH2 domain-containing protein 2A" [UniProt:Q9QXK9]
exact_synonym: "Sh2d2a" [MGI:1351596, UniProt:Q9QXK9]
exact_synonym: "TSAd" [MGI:1351596]
xref_analog: UniProt:Q9QXK9
relationship: sequence_of IMR:0001652 ! VRAP

[Term]
id: IMR:0001655
name: LPS
def: "Lipopolysaccharide (LPS) is a glycosylated lipid on the outer surface of Gram-negative bacteria acts as immunostimulants." [ISBN:0815340729]
exact_synonym: "lipopolysaccharide" []
xref_analog: CHEBI:16412
xref_analog: KEGG:C00338
xref_analog: MeSH:D008070
is_a: IMR:0000965 ! chemical ligand
is_a: IMR:0001362 ! lipid
is_a: IMR:0001790 ! polysaccharide

[Term]
id: IMR:0001656
name: vitamin
xref_analog: CHEBI:27305
is_a: IMR:0000947 ! chemical

[Term]
id: IMR:0001657
name: carbohydrate
def: "The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n." [MeSH:D002241]
xref_analog: CHEBI:23008
xref_analog: MeSH:D002241
is_a: IMR:0000947 ! chemical

[Term]
id: IMR:0001658
name: ion
def: "An atom that has either gained or lost electrons to acquire a chage; for example Na+ and Cl-." [ISBN:0815340729]
xref_analog: CHEBI:24870
is_a: IMR:0000947 ! chemical

[Term]
id: IMR:0001659
name: RGS1
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001660
name: RGS2
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001661
name: RGS3
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001662
name: RGS4
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001663
name: RGS5
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001664
name: RGS6
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001665
name: RGS7
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001666
name: RGS8
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001667
name: RGS9
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001668
name: RGS10
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001669
name: RGS11
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001670
name: RGS12
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001671
name: RGS13
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001672
name: RGS14
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001673
name: RGS16
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001674
name: RGS17
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001675
name: RGS18
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001676
name: RGS19
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001677
name: RGS20
is_a: IMR:0000431 ! RGS

[Term]
id: IMR:0001678
name: RGS13_MOUSE
exact_synonym: "Regulator of G-protein signaling 13" [UniProt:Q8K443]
exact_synonym: "regulator of G-protein signaling 13" [MGI:2180585]
exact_synonym: "RGS13" [UniProt:Q8K443]
exact_synonym: "Rgs13" [MGI:2180585, UniProt:Q8K443]
xref_analog: UniProt:Q8K443
relationship: sequence_of IMR:0001671 ! RGS13

[Term]
id: IMR:0001679
name: RGS8_MOUSE
exact_synonym: "Regulator of G-protein signaling 8" [UniProt:Q8BXT1]
exact_synonym: "regulator of G-protein signaling 8" [MGI:108408]
exact_synonym: "RGS8" [UniProt:Q8BXT1]
exact_synonym: "Rgs8" [MGI:108408, UniProt:Q8BXT1]
xref_analog: UniProt:Q8BXT1
relationship: sequence_of IMR:0001666 ! RGS8

[Term]
id: IMR:0001680
name: AXN2_HUMAN
exact_synonym: "Axil" [UniProt:Q9Y2T1]
exact_synonym: "AXIL" [EntrezGene:8313]
exact_synonym: "axin 2" [EntrezGene:8313, HGNC:904]
exact_synonym: "Axin-2" [UniProt:Q9Y2T1]
exact_synonym: "Axin-like protein" [UniProt:Q9Y2T1]
exact_synonym: "AXIN2" [MIM:604025, EntrezGene:8313, HGNC:904, UniProt:Q9Y2T1]
exact_synonym: "Axis inhibition protein 2" [UniProt:Q9Y2T1]
exact_synonym: "AXIS INHIBITOR 2" [MIM:604025]
exact_synonym: "Conductin" [UniProt:Q9Y2T1]
exact_synonym: "CONDUCTIN, MOUSE, HOMOLOG OF" [MIM:604025]
exact_synonym: "DKFZp781B0869" [EntrezGene:8313, HGNC:904]
exact_synonym: "MGC10366" [EntrezGene:8313]
exact_synonym: "MGC126582" [EntrezGene:8313, HGNC:904]
xref_analog: UniProt:Q9Y2T1
relationship: sequence_of IMR:0001216 ! Axin2

[Term]
id: IMR:0001681
name: GSK3_CAEEL
exact_synonym: "EC 2.7.11.26" [UniProt:Q9U2Q9]
exact_synonym: "Glycogen synthase kinase-3" [UniProt:Q9U2Q9]
exact_synonym: "gsk-3" [UniProt:Q9U2Q9]
exact_synonym: "sgg-1" [UniProt:Q9U2Q9]
xref_analog: UniProt:Q9U2Q9
relationship: sequence_of IMR:0000257 ! GSK3

[Term]
id: IMR:0001682
name: UNC37_CAEEL
exact_synonym: "esg" [UniProt:O02482]
exact_synonym: "Transcription factor unc-37" [UniProt:O02482]
exact_synonym: "unc-37" [UniProt:O02482]
exact_synonym: "Uncoordinated protein 37" [UniProt:O02482]
xref_analog: UniProt:O02482
relationship: sequence_of IMR:0100748 ! Groucho/TLE family

[Term]
id: IMR:0001683
name: Q4V6B6_DROME
exact_synonym: "Cby" [FlyBase:FBgn0067317, UniProt:Q4V6B6]
exact_synonym: "CG13415" [FlyBase:FBgn0067317, UniProt:Q4V6B6]
exact_synonym: "Chibby" [FlyBase:FBgn0067317]
exact_synonym: "IP05256p" [UniProt:Q4V6B6]
exact_synonym: "IP05356p" [UniProt:Q4V6B6]
xref_analog: UniProt:Q4V6B6
relationship: sequence_of IMR:0001159 ! chibby

[Term]
id: IMR:0001684
name: WNT8_XENLA
exact_synonym: "Protein Wnt-8" [UniProt:P28026]
exact_synonym: "wnt8" [UniProt:P28026]
exact_synonym: "XWnt-8" [UniProt:P28026]
xref_analog: UniProt:P28026
relationship: sequence_of IMR:0100776 ! Wnt-8a

[Term]
id: IMR:0001685
name: WNT8B_XENLA
exact_synonym: "Protein Wnt-8b" [UniProt:P31291]
exact_synonym: "wnt8b" [UniProt:P31291]
exact_synonym: "XWnt-8b" [UniProt:P31291]
xref_analog: UniProt:P31291
relationship: sequence_of IMR:0100777 ! Wnt-8b

[Term]
id: IMR:0001686
name: FZD2_XENLA
exact_synonym: "Frizzled-2" [UniProt:Q9PUU6]
exact_synonym: "Fz-2" [UniProt:Q9PUU6]
exact_synonym: "fz2" [UniProt:Q9PUU6]
exact_synonym: "fzd2" [UniProt:Q9PUU6]
exact_synonym: "Xfz2" [UniProt:Q9PUU6]
xref_analog: UniProt:Q9PUU6
relationship: sequence_of IMR:0100789 ! Fz-2

[Term]
id: IMR:0001687
name: FZD1_XENLA
exact_synonym: "Frizzled-1" [UniProt:Q9I9M5]
exact_synonym: "Fz-1" [UniProt:Q9I9M5]
exact_synonym: "fz1" [UniProt:Q9I9M5]
exact_synonym: "fzd1" [UniProt:Q9I9M5]
exact_synonym: "Xfz1" [UniProt:Q9I9M5]
xref_analog: UniProt:Q9I9M5
relationship: sequence_of IMR:0100788 ! Fz-1

[Term]
id: IMR:0001688
name: MAPK5_HUMAN
exact_synonym: "EC 2.7.11.1" [UniProt:Q8IW41]
exact_synonym: "MAP kinase-activated protein kinase 5" [UniProt:Q8IW41]
exact_synonym: "MAPK-activated protein kinase 5" [UniProt:Q8IW41]
exact_synonym: "MAPKAP kinase 5" [MIM:606723, UniProt:Q8IW41]
exact_synonym: "MAPKAPK-5" [UniProt:Q8IW41]
exact_synonym: "MAPKAPK5" [HGNC:6889, MIM:606723, EntrezGene:8550, UniProt:Q8IW41]
exact_synonym: "mitogen-activated protein kinase-activated protein kinase 5" [HGNC:6889, MIM:606723, EntrezGene:8550]
exact_synonym: "p38-REGULATED/ACTIVATED KINASE" [MIM:606723]
exact_synonym: "p38-regulated/activated protein kinase" [UniProt:Q8IW41]
exact_synonym: "PRAK" [HGNC:6889, MIM:606723, EntrezGene:8550, UniProt:Q8IW41]
xref_analog: UniProt:Q8IW41
relationship: sequence_of IMR:0100272 ! MAPKAPK5

[Term]
id: IMR:0001689
name: MAPKAPK2/3
def: "MAPKAPK2 and MAPKAPK3 can be activated by p38 and  activated MAPKAPK2/3 can phosphorylate small heat shock protein 27 (HSP27)." [PubMed:9628874]
exact_synonym: "MAP kinase-activated protein kinase 2/3" []
exact_synonym: "MAPK-activated protein kinase 2/3" []
is_a: IMR:0100271 ! MAPKAPK

[Term]
id: IMR:0001690
name: MNK1
exact_synonym: "MAP kinase signal-integrating kinase 1" []
exact_synonym: "MAP kinase-interacting kinase 1" []
is_a: IMR:0100273 ! MNK

[Term]
id: IMR:0001691
name: MNK2
exact_synonym: "MAP kinase signal-integrating kinase 2" []
exact_synonym: "MAP kinase-interacting kinase 2" []
is_a: IMR:0100273 ! MNK

[Term]
id: IMR:0001692
name: HSP27
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0001693
name: amin
def: "A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)" [MeSH:D000588]
xref_analog: CHEBI:32952
xref_analog: MeSH:D000588
is_a: IMR:0000947 ! chemical

[Term]
id: IMR:0001694
name: catecholamine
xref_analog: CHEBI:33567
is_a: IMR:0002121 ! biogenic amine

[Term]
id: IMR:0001695
name: amino acid
def: "Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins." [MeSH:D000596]
xref_analog: CHEBI:33709
xref_analog: MeSH:D000596
is_a: IMR:0000947 ! chemical

[Term]
id: IMR:0001697
name: nucleoside
xref_analog: CHEBI:25611
is_a: IMR:0000947 ! chemical
is_a: IMR:0001698 ! glycoside

[Term]
id: IMR:0001698
name: glycoside
def: "Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)" [MeSH:D006027]
is_a: IMR:0001657 ! carbohydrate

[Term]
id: IMR:0001699
name: peptidoglycan
def: "Peptidoglycan (PGN) is a unique and essential component of the cell wall of virtually all bacteria, is not present in eukaryotes, and is an excellent target for the innate immune system." [PubMed:16263004]
exact_synonym: "murein" []
exact_synonym: "PGN" []
xref_analog: KEGG:C00889
xref_analog: MeSH:D010457
is_a: IMR:0000965 ! chemical ligand
is_a: IMR:0001700 ! peptide
is_a: IMR:0001790 ! polysaccharide

[Term]
id: IMR:0001700
name: peptide
def: "The polypeptide that is not a gene product." [INOH:SY]
is_a: IMR:0000947 ! chemical

[Term]
id: IMR:0001701
name: ANF_HUMAN
exact_synonym: "ANF" [UniProt:P01160, MIM:108780, EntrezGene:4878]
exact_synonym: "ANP" [UniProt:P01160, MIM:108780, EntrezGene:4878]
exact_synonym: "ATFB6" [EntrezGene:4878]
exact_synonym: "Atrial natriuretic factor" [UniProt:P01160, MIM:108780]
exact_synonym: "Atrial natriuretic peptide" [UniProt:P01160]
exact_synonym: "ATRIAL NATRIURETIC POLYPEPTIDES" [MIM:108780]
exact_synonym: "ATRIONATRIURETIC FACTOR" [MIM:108780]
exact_synonym: "ATRIOPEPTIN" [MIM:108780]
exact_synonym: "Cardiodilatin-related peptide" [UniProt:P01160]
exact_synonym: "CARDIONATRIN" [MIM:108780]
exact_synonym: "CDD-ANF" [UniProt:P01160, EntrezGene:4878]
exact_synonym: "CDP" [UniProt:P01160]
exact_synonym: "natriuretic peptide A" [HGNC:7939, EntrezGene:4878]
exact_synonym: "NATRIURETIC PEPTIDE PRECURSOR A" [MIM:108780]
exact_synonym: "NPPA" [HGNC:7939, UniProt:P01160, MIM:108780, EntrezGene:4878]
exact_synonym: "PND" [UniProt:P01160, MIM:108780, EntrezGene:4878]
exact_synonym: "Prepronatriodilatin" [UniProt:P01160]
exact_synonym: "PRONATRIODILATIN" [MIM:108780]
xref_analog: UniProt:P01160
relationship: sequence_of IMR:0100164 ! atrial natriuretic factor

[Term]
id: IMR:0001702
name: ANF_MOUSE
exact_synonym: "ANF" [UniProt:P05125]
exact_synonym: "Anf" [MGI:97367]
exact_synonym: "ANP" [UniProt:P05125, MGI:97367]
exact_synonym: "Atrial natriuretic factor" [UniProt:P05125]
exact_synonym: "Atrial natriuretic peptide" [UniProt:P05125]
exact_synonym: "atrial natriuretic peptide" [MGI:97367]
exact_synonym: "Atriopeptin I" [UniProt:P05125]
exact_synonym: "Atriopeptin II" [UniProt:P05125]
exact_synonym: "Atriopeptin-1" [UniProt:P05125]
exact_synonym: "Atriopeptin-2" [UniProt:P05125]
exact_synonym: "Auriculin-A" [UniProt:P05125]
exact_synonym: "Auriculin-B" [UniProt:P05125]
exact_synonym: "natriuretic peptide precursor A" [MGI:97367]
exact_synonym: "natriuretic peptide type A" [MGI:97367]
exact_synonym: "Nppa" [UniProt:P05125, MGI:97367]
exact_synonym: "Pnd" [UniProt:P05125, MGI:97367]
exact_synonym: "Prepronatriodilatin" [UniProt:P05125]
xref_analog: UniProt:P05125
relationship: sequence_of IMR:0100164 ! atrial natriuretic factor

[Term]
id: IMR:0001703
name: ANF_RAT
exact_synonym: "ANF" [UniProt:P01161]
exact_synonym: "ANP" [UniProt:P01161]
exact_synonym: "Atrial natriuretic factor" [UniProt:P01161]
exact_synonym: "Atrial natriuretic peptide" [UniProt:P01161]
exact_synonym: "Atriopeptin I" [UniProt:P01161]
exact_synonym: "Atriopeptin II" [UniProt:P01161]
exact_synonym: "Atriopeptin III" [UniProt:P01161]
exact_synonym: "Atriopeptin-1" [UniProt:P01161]
exact_synonym: "Atriopeptin-2" [UniProt:P01161]
exact_synonym: "Atriopeptin-3" [UniProt:P01161]
exact_synonym: "Auriculin-A" [UniProt:P01161]
exact_synonym: "Auriculin-B" [UniProt:P01161]
exact_synonym: "natriuretic peptide precursor A" [RGD:3193]
exact_synonym: "Nppa" [RGD:3193, UniProt:P01161]
exact_synonym: "Prepronatriodilatin" [UniProt:P01161]
xref_analog: UniProt:P01161
relationship: sequence_of IMR:0100164 ! atrial natriuretic factor

[Term]
id: IMR:0001704
name: EDN3_HUMAN
exact_synonym: "EDN3" [UniProt:P14138, HGNC:3178, EntrezGene:1908, MIM:131242]
exact_synonym: "endothelin 3" [HGNC:3178, EntrezGene:1908, MIM:131242]
exact_synonym: "Endothelin-3" [UniProt:P14138]
exact_synonym: "ET-3" [UniProt:P14138]
exact_synonym: "ET3" [HGNC:3178, EntrezGene:1908, MIM:131242]
exact_synonym: "HSCR4" [EntrezGene:1908]
exact_synonym: "MGC15067" [EntrezGene:1908]
exact_synonym: "MGC61498" [EntrezGene:1908]
exact_synonym: "PPET3" [UniProt:P14138]
exact_synonym: "Preproendothelin-3" [UniProt:P14138]
exact_synonym: "WS4B" [EntrezGene:1908]
xref_analog: UniProt:P14138
relationship: sequence_of IMR:0100169 ! endothelin-3

[Term]
id: IMR:0001705
name: EDN3_MOUSE
exact_synonym: "114-CH19" [MGI:95285]
exact_synonym: "114CH19" [MGI:95285]
exact_synonym: "Edn3" [UniProt:P48299, MGI:95285]
exact_synonym: "endothelin 3" [MGI:95285]
exact_synonym: "Endothelin-3" [UniProt:P48299]
exact_synonym: "ET-3" [UniProt:P48299]
exact_synonym: "PPET3" [UniProt:P48299]
exact_synonym: "Preproendothelin-3" [UniProt:P48299]
exact_synonym: "tmgc48" [MGI:95285]
xref_analog: UniProt:P48299
relationship: sequence_of IMR:0100169 ! endothelin-3

[Term]
id: IMR:0001706
name: EDN3_RAT
exact_synonym: "Edn3" [UniProt:P13207, RGD:2534]
exact_synonym: "endothelin 3" [RGD:2534]
exact_synonym: "Endothelin-3" [UniProt:P13207]
exact_synonym: "ET-3" [UniProt:P13207]
exact_synonym: "PPET3" [UniProt:P13207]
exact_synonym: "Preproendothelin-3" [UniProt:P13207]
xref_analog: UniProt:P13207
relationship: sequence_of IMR:0100169 ! endothelin-3

[Term]
id: IMR:0001707
name: NPY_HUMAN
exact_synonym: "C-flanking peptide of NPY" [UniProt:P01303]
exact_synonym: "CPON" [UniProt:P01303]
exact_synonym: "Neuropeptide tyrosine" [UniProt:P01303]
exact_synonym: "Neuropeptide Y" [MIM:162640, UniProt:P01303]
exact_synonym: "neuropeptide Y" [EntrezGene:4852, HGNC:7955]
exact_synonym: "NPY" [EntrezGene:4852, MIM:162640, HGNC:7955, UniProt:P01303]
exact_synonym: "PYY4" [EntrezGene:4852, HGNC:7955]
exact_synonym: "Y NEUROPEPTIDE" [MIM:162640]
xref_analog: UniProt:P01303
relationship: sequence_of IMR:0100146 ! neuropeptide Y

[Term]
id: IMR:0001708
name: NPY_MOUSE
exact_synonym: "C-flanking peptide of NPY" [UniProt:P57774]
exact_synonym: "CPON" [UniProt:P57774]
exact_synonym: "Neuropeptide tyrosine" [UniProt:P57774]
exact_synonym: "Neuropeptide Y" [UniProt:P57774]
exact_synonym: "neuropeptide Y" [MGI:97374]
exact_synonym: "Npy" [UniProt:P57774, MGI:97374]
exact_synonym: "NPY" [UniProt:P57774]
xref_analog: UniProt:P57774
relationship: sequence_of IMR:0100146 ! neuropeptide Y

[Term]
id: IMR:0001709
name: NPY_RAT
exact_synonym: "C-flanking peptide of NPY" [UniProt:P07808]
exact_synonym: "CPON" [UniProt:P07808]
exact_synonym: "Neuropeptide tyrosine" [UniProt:P07808]
exact_synonym: "Neuropeptide Y" [UniProt:P07808]
exact_synonym: "neuropeptide Y" [RGD:3197]
exact_synonym: "Npy" [RGD:3197, UniProt:P07808]
exact_synonym: "NPY" [UniProt:P07808]
xref_analog: UniProt:P07808
relationship: sequence_of IMR:0100146 ! neuropeptide Y

[Term]
id: IMR:0001711
name: vinculin
def: "Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane." [UniProt:P18206]
is_a: IMR:0000188 ! microfilament cytoskeletal protein

[Term]
id: IMR:0001712
name: VINC_HUMAN
exact_synonym: "CMD1W" [EntrezGene:7414]
exact_synonym: "CMH15" [EntrezGene:7414]
exact_synonym: "Metavinculin" [UniProt:P18206]
exact_synonym: "MVCL" [EntrezGene:7414]
exact_synonym: "VCL" [UniProt:P18206, HGNC:12665, MIM:193065, EntrezGene:7414]
exact_synonym: "Vinculin" [UniProt:P18206, MIM:193065]
exact_synonym: "vinculin" [HGNC:12665, EntrezGene:7414]
xref_analog: UniProt:P18206
relationship: sequence_of IMR:0001711 ! vinculin

[Term]
id: IMR:0001713
name: VINC_MOUSE
exact_synonym: "Metavinculin" [UniProt:Q64727]
exact_synonym: "metavinculin" [MGI:98927]
exact_synonym: "Vcl" [UniProt:Q64727, MGI:98927]
exact_synonym: "Vinculin" [UniProt:Q64727]
exact_synonym: "vinculin" [MGI:98927]
xref_analog: UniProt:Q64727
relationship: sequence_of IMR:0001711 ! vinculin

[Term]
id: IMR:0001714
name: talin
def: "Mammals have two highly similar isoforms of talin suggesting redundant functions." [PubMed:12743027]
is_a: IMR:0000188 ! microfilament cytoskeletal protein

[Term]
id: IMR:0001715
name: talin-1
is_a: IMR:0001714 ! talin

[Term]
id: IMR:0001716
name: TLN1_HUMAN
exact_synonym: "ILWEQ" [EntrezGene:7094, HGNC:11845]
exact_synonym: "KIAA1027" [EntrezGene:7094, UniProt:Q9Y490]
exact_synonym: "TALIN" [MIM:186745]
exact_synonym: "talin 1" [EntrezGene:7094, MIM:186745, HGNC:11845]
exact_synonym: "Talin-1" [UniProt:Q9Y490]
exact_synonym: "TLN" [EntrezGene:7094, UniProt:Q9Y490, MIM:186745]
exact_synonym: "TLN1" [EntrezGene:7094, UniProt:Q9Y490, MIM:186745, HGNC:11845]
xref_analog: UniProt:Q9Y490
relationship: sequence_of IMR:0001715 ! talin-1

[Term]
id: IMR:0001717
name: TLN1_MOUSE
exact_synonym: "talin 1" [MGI:1099832]
exact_synonym: "Talin-1" [UniProt:P26039]
exact_synonym: "Tln" [UniProt:P26039]
exact_synonym: "Tln1" [UniProt:P26039, MGI:1099832]
xref_analog: UniProt:P26039
relationship: sequence_of IMR:0001715 ! talin-1

[Term]
id: IMR:0001718
name: talin-2
is_a: IMR:0001714 ! talin

[Term]
id: IMR:0001719
name: TLN2_HUMAN
exact_synonym: "DKFZp451B1011" [EntrezGene:83660]
exact_synonym: "DKFZp686I0976" [EntrezGene:83660]
exact_synonym: "DKFZp686K0979" [EntrezGene:83660]
exact_synonym: "ILWEQ" [EntrezGene:83660, HGNC:15447]
exact_synonym: "KIAA0320" [EntrezGene:83660, MIM:607349, HGNC:15447, UniProt:Q9Y4G6]
exact_synonym: "talin 2" [EntrezGene:83660, MIM:607349, HGNC:15447]
exact_synonym: "Talin-2" [UniProt:Q9Y4G6]
exact_synonym: "TLN2" [EntrezGene:83660, MIM:607349, HGNC:15447, UniProt:Q9Y4G6]
xref_analog: UniProt:Q9Y4G6
relationship: sequence_of IMR:0001718 ! talin-2

[Term]
id: IMR:0001720
name: gas
def: "The vapor state of matter; nonelastic fluids in which the molecules are in free movement and their mean positions far apart. Gases tend to expand indefinitely, to diffuse and mix readily with other gases, to have definite relations of volume, temperature, and pressure, and to condense or liquefy at low temperatures or under sufficient pressure." [MeSH:D005740]
xref_analog: MeSH:D005740
is_a: IMR:0000947 ! chemical

[Term]
id: IMR:0001721
name: AT1R
exact_synonym: "angiotensin II type 1 receptor" []
is_a: IMR:0000138 ! Rhodopsin-like GPCR(typeA)

[Term]
id: IMR:0001722
name: AGTR1_HUMAN
exact_synonym: "AG2S" [HGNC:336, EntrezGene:185]
exact_synonym: "AGTR1" [HGNC:336, MIM:106165, EntrezGene:185, UniProt:P30556]
exact_synonym: "AGTR1A" [HGNC:336, MIM:106165, EntrezGene:185, UniProt:P30556]
exact_synonym: "AGTR1B" [EntrezGene:185, UniProt:P30556]
exact_synonym: "angiotensin II receptor, type 1" [HGNC:336, EntrezGene:185]
exact_synonym: "ANGIOTENSIN II RECEPTOR, VASCULAR TYPE 1" [MIM:106165]
exact_synonym: "Angiotensin II type-1 receptor" [UniProt:P30556]
exact_synonym: "ANGIOTENSIN RECEPTOR 1" [MIM:106165]
exact_synonym: "ANGIOTENSIN RECEPTOR 1A" [MIM:106165]
exact_synonym: "AT1" [HGNC:336, EntrezGene:185, UniProt:P30556]
exact_synonym: "AT1AR" [UniProt:P30556]
exact_synonym: "AT1B" [HGNC:336, EntrezGene:185]
exact_synonym: "AT1BR" [UniProt:P30556]
exact_synonym: "AT1R" [MIM:106165, EntrezGene:185]
exact_synonym: "AT2R1" [HGNC:336, MIM:106165, EntrezGene:185, UniProt:P30556]
exact_synonym: "AT2R1A" [HGNC:336, EntrezGene:185]
exact_synonym: "AT2R1B" [HGNC:336, EntrezGene:185, UniProt:P30556]
exact_synonym: "HAT1R" [HGNC:336, EntrezGene:185]
exact_synonym: "Type-1 angiotensin II receptor" [UniProt:P30556]
xref_analog: UniProt:P30556
relationship: sequence_of IMR:0001721 ! AT1R

[Term]
id: IMR:0001723
name: AGTRA_MOUSE
exact_synonym: "Agtr-1a" [MGI:87964]
exact_synonym: "Agtr1" [UniProt:P29754]
exact_synonym: "Agtr1a" [MGI:87964, UniProt:P29754]
exact_synonym: "angiotensin II receptor, type 1a" [MGI:87964]
exact_synonym: "Angiotensin II type-1A receptor" [UniProt:P29754]
exact_synonym: "Angtr-1a" [MGI:87964]
exact_synonym: "AT1" [MGI:87964]
exact_synonym: "AT1A" [UniProt:P29754]
exact_synonym: "AT1a" [MGI:87964]
exact_synonym: "Type-1A angiotensin II receptor" [UniProt:P29754]
xref_analog: UniProt:P29754
relationship: sequence_of IMR:0001721 ! AT1R

[Term]
id: IMR:0001724
name: AGTRA_RAT
exact_synonym: "Agtr1" [UniProt:P25095]
exact_synonym: "Agtr1a" [RGD:2070, UniProt:P25095]
exact_synonym: "angiotensin II receptor, type 1a" [RGD:2070]
exact_synonym: "Angiotensin II type-1A receptor" [UniProt:P25095]
exact_synonym: "AT1A" [UniProt:P25095]
exact_synonym: "At1a" [UniProt:P25095]
exact_synonym: "Type-1A angiotensin II receptor" [UniProt:P25095]
xref_analog: UniProt:P25095
relationship: sequence_of IMR:0001721 ! AT1R

[Term]
id: IMR:0001725
name: AT2R
exact_synonym: "angiotensin II type 2 receptor" []
is_a: IMR:0000138 ! Rhodopsin-like GPCR(typeA)

[Term]
id: IMR:0001726
name: AGTR2_HUMAN
exact_synonym: "AGTR2" [HGNC:338, UniProt:P50052, EntrezGene:186]
exact_synonym: "angiotensin II receptor, type 2" [HGNC:338, EntrezGene:186]
exact_synonym: "Angiotensin II type-2 receptor" [UniProt:P50052]
exact_synonym: "AT2" [HGNC:338, UniProt:P50052, EntrezGene:186]
exact_synonym: "ATGR2" [EntrezGene:186]
exact_synonym: "MRX88" [HGNC:338, EntrezGene:186]
exact_synonym: "Type-2 angiotensin II receptor" [UniProt:P50052]
xref_analog: UniProt:P50052
relationship: sequence_of IMR:0001725 ! AT2R

[Term]
id: IMR:0001727
name: AGTR2_MOUSE
exact_synonym: "Agtr2" [UniProt:P35374, MGI:87966]
exact_synonym: "angiotensin II receptor, type 2" [MGI:87966]
exact_synonym: "Angiotensin II type-2 receptor" [UniProt:P35374]
exact_synonym: "AT2" [UniProt:P35374]
exact_synonym: "AT2 receptor" [MGI:87966]
exact_synonym: "Type-2 angiotensin II receptor" [UniProt:P35374]
xref_analog: UniProt:P35374
relationship: sequence_of IMR:0001725 ! AT2R

[Term]
id: IMR:0001728
name: AGTR2_RAT
exact_synonym: "Agtr2" [RGD:2072, UniProt:P35351]
exact_synonym: "angiotensin II receptor, type 2" [RGD:2072]
exact_synonym: "Angiotensin II type-2 receptor" [UniProt:P35351]
exact_synonym: "AT2" [UniProt:P35351]
exact_synonym: "Type-2 angiotensin II receptor" [UniProt:P35351]
xref_analog: UniProt:P35351
relationship: sequence_of IMR:0001725 ! AT2R

[Term]
id: IMR:0001729
name: group I mGluR
exact_synonym: "group I metabotropic glutamate receptor" []
exact_synonym: "group I mGlu receptor" []
is_a: IMR:0000140 ! metabotropic glutamate/pheromone receptors(type C)

[Term]
id: IMR:0001730
name: mGluR1
is_a: IMR:0001729 ! group I mGluR

[Term]
id: IMR:0001731
name: mGluR5
is_a: IMR:0001729 ! group I mGluR

[Term]
id: IMR:0001732
name: group II mGluR
is_a: IMR:0000140 ! metabotropic glutamate/pheromone receptors(type C)

[Term]
id: IMR:0001733
name: mGluR2
is_a: IMR:0001732 ! group II mGluR

[Term]
id: IMR:0001734
name: mGluR3
is_a: IMR:0001732 ! group II mGluR

[Term]
id: IMR:0001735
name: group III mGluR
is_a: IMR:0000140 ! metabotropic glutamate/pheromone receptors(type C)

[Term]
id: IMR:0001736
name: mGluR4
is_a: IMR:0001735 ! group III mGluR

[Term]
id: IMR:0001737
name: mGluR6
is_a: IMR:0001735 ! group III mGluR

[Term]
id: IMR:0001738
name: mGluR7
is_a: IMR:0001735 ! group III mGluR

[Term]
id: IMR:0001739
name: mGluR8
is_a: IMR:0001735 ! group III mGluR

[Term]
id: IMR:0001740
name: GRM1_HUMAN
exact_synonym: "glutamate receptor, metabotropic 1" [EntrezGene:2911, HGNC:4593]
exact_synonym: "GLUTAMATE RECEPTOR, METABOTROPIC, 1" [MIM:604473]
exact_synonym: "GPRC1A" [EntrezGene:2911, HGNC:4593, UniProt:Q13255]
exact_synonym: "GRM1" [EntrezGene:2911, HGNC:4593, MIM:604473, UniProt:Q13255]
exact_synonym: "GRM1-ALPHA" [MIM:604473]
exact_synonym: "GRM1A" [EntrezGene:2911, MIM:604473]
exact_synonym: "Metabotropic glutamate receptor 1" [UniProt:Q13255]
exact_synonym: "mGlu1" [EntrezGene:2911, HGNC:4593]
exact_synonym: "MGLUR1" [EntrezGene:2911, HGNC:4593, MIM:604473, UniProt:Q13255]
exact_synonym: "mGluR1" [UniProt:Q13255]
exact_synonym: "MGLUR1-ALPHA" [MIM:604473]
exact_synonym: "MGLUR1A" [EntrezGene:2911, MIM:604473]
xref_analog: UniProt:Q13255
relationship: sequence_of IMR:0001730 ! mGluR1

[Term]
id: IMR:0001741
name: GRM1_MOUSE
exact_synonym: "glutamate receptor, metabotropic 1" [MGI:1351338]
exact_synonym: "Gprc1a" [UniProt:P97772, MGI:1351338]
exact_synonym: "Grm1" [UniProt:P97772, MGI:1351338]
exact_synonym: "Metabotropic glutamate receptor 1" [UniProt:P97772]
exact_synonym: "Mglur1" [UniProt:P97772]
exact_synonym: "mGluR1" [UniProt:P97772, MGI:1351338]
exact_synonym: "nmf373" [MGI:1351338]
exact_synonym: "rcw" [MGI:1351338]
xref_analog: UniProt:P97772
relationship: sequence_of IMR:0001730 ! mGluR1

[Term]
id: IMR:0001742
name: GRM1_RAT
exact_synonym: "glutamate receptor, metabotropic 1" [RGD:2742]
exact_synonym: "Gprc1a" [UniProt:P23385]
exact_synonym: "Grm1" [RGD:2742, UniProt:P23385]
exact_synonym: "Metabotropic glutamate receptor 1" [UniProt:P23385]
exact_synonym: "Mglur1" [UniProt:P23385]
exact_synonym: "mGluR1" [UniProt:P23385]
xref_analog: UniProt:P23385
relationship: sequence_of IMR:0001730 ! mGluR1

[Term]
id: IMR:0001743
name: GRM2_HUMAN
exact_synonym: "glutamate receptor, metabotropic 2" [HGNC:4594]
exact_synonym: "GLUTAMATE RECEPTOR, METABOTROPIC, 2" [MIM:604099]
exact_synonym: "GPRC1B" [HGNC:4594, UniProt:Q14416]
exact_synonym: "GRM2" [MIM:604099, HGNC:4594, UniProt:Q14416]
exact_synonym: "Metabotropic glutamate receptor 2" [UniProt:Q14416]
exact_synonym: "mGlu2" [HGNC:4594]
exact_synonym: "MGLUR2" [MIM:604099, HGNC:4594, UniProt:Q14416]
exact_synonym: "mGluR2" [UniProt:Q14416]
xref_analog: UniProt:Q14416
relationship: sequence_of IMR:0001733 ! mGluR2

[Term]
id: IMR:0001744
name: GRM2_RAT
exact_synonym: "glutamate receptor, metabotropic 2" [RGD:2743]
exact_synonym: "Gprc1b" [UniProt:P31421]
exact_synonym: "Grm2" [UniProt:P31421, RGD:2743]
exact_synonym: "Metabotropic glutamate receptor 2" [UniProt:P31421]
exact_synonym: "Mglur2" [UniProt:P31421]
exact_synonym: "mGluR2" [UniProt:P31421]
xref_analog: UniProt:P31421
relationship: sequence_of IMR:0001733 ! mGluR2

[Term]
id: IMR:0001745
name: GRM3_HUMAN
exact_synonym: "glutamate receptor, metabotropic 3" [HGNC:4595]
exact_synonym: "GLUTAMATE RECEPTOR, METABOTROPIC, 3" [MIM:601115]
exact_synonym: "GPRC1C" [HGNC:4595, UniProt:Q14832]
exact_synonym: "GRM3" [HGNC:4595, MIM:601115, UniProt:Q14832]
exact_synonym: "Metabotropic glutamate receptor 3" [UniProt:Q14832]
exact_synonym: "mGlu3" [HGNC:4595]
exact_synonym: "MGLUR3" [HGNC:4595, MIM:601115, UniProt:Q14832]
exact_synonym: "mGluR3" [UniProt:Q14832]
xref_analog: UniProt:Q14832
relationship: sequence_of IMR:0001734 ! mGluR3

[Term]
id: IMR:0001746
name: GRM3_MOUSE
exact_synonym: "glutamate receptor, metabotropic 3" [MGI:1351340]
exact_synonym: "Gprc1c" [UniProt:Q9QYS2, MGI:1351340]
exact_synonym: "Grm3" [UniProt:Q9QYS2, MGI:1351340]
exact_synonym: "Metabotropic glutamate receptor 3" [UniProt:Q9QYS2]
exact_synonym: "mGlu3" [MGI:1351340]
exact_synonym: "Mglur3" [UniProt:Q9QYS2]
exact_synonym: "mGluR3" [UniProt:Q9QYS2, MGI:1351340]
xref_analog: UniProt:Q9QYS2
relationship: sequence_of IMR:0001734 ! mGluR3

[Term]
id: IMR:0001747
name: GRM3_RAT
exact_synonym: "glutamate receptor, metabotropic 3" [RGD:2744]
exact_synonym: "Gprc1c" [UniProt:P31422]
exact_synonym: "Grm3" [RGD:2744, UniProt:P31422]
exact_synonym: "Metabotropic glutamate receptor 3" [UniProt:P31422]
exact_synonym: "Mglur3" [UniProt:P31422]
exact_synonym: "mGluR3" [UniProt:P31422]
xref_analog: UniProt:P31422
relationship: sequence_of IMR:0001734 ! mGluR3

[Term]
id: IMR:0001748
name: GRM4_HUMAN
exact_synonym: "glutamate receptor, metabotropic 4" [HGNC:4596]
exact_synonym: "GLUTAMATE RECEPTOR, METABOTROPIC, 4" [MIM:604100]
exact_synonym: "GPRC1D" [UniProt:Q14833, HGNC:4596]
exact_synonym: "GRM4" [MIM:604100, UniProt:Q14833, HGNC:4596]
exact_synonym: "Metabotropic glutamate receptor 4" [UniProt:Q14833]
exact_synonym: "mGlu4" [HGNC:4596]
exact_synonym: "MGLUR4" [MIM:604100, UniProt:Q14833, HGNC:4596]
exact_synonym: "mGluR4" [UniProt:Q14833]
xref_analog: UniProt:Q14833
relationship: sequence_of IMR:0001736 ! mGluR4

[Term]
id: IMR:0001749
name: GRM4_RAT
exact_synonym: "glutamate receptor, metabotropic 4" [RGD:2745]
exact_synonym: "Gprc1d" [UniProt:P31423]
exact_synonym: "Grm4" [RGD:2745, UniProt:P31423]
exact_synonym: "Metabotropic glutamate receptor 4" [UniProt:P31423]
exact_synonym: "Mglur4" [UniProt:P31423]
exact_synonym: "mGluR4" [UniProt:P31423]
xref_analog: UniProt:P31423
relationship: sequence_of IMR:0001736 ! mGluR4

[Term]
id: IMR:0001750
name: GRM5_HUMAN
exact_synonym: "glutamate receptor, metabotropic 5" [EntrezGene:2915, HGNC:4597]
exact_synonym: "GLUTAMATE RECEPTOR, METABOTROPIC, 5" [MIM:604102]
exact_synonym: "GPRC1E" [EntrezGene:2915, HGNC:4597, UniProt:P41594]
exact_synonym: "GRM5" [MIM:604102, EntrezGene:2915, HGNC:4597, UniProt:P41594]
exact_synonym: "Metabotropic glutamate receptor 5" [UniProt:P41594]
exact_synonym: "mGlu5" [EntrezGene:2915, HGNC:4597]
exact_synonym: "MGLUR5" [MIM:604102, EntrezGene:2915, HGNC:4597, UniProt:P41594]
exact_synonym: "mGluR5" [UniProt:P41594]
xref_analog: UniProt:P41594
relationship: sequence_of IMR:0001731 ! mGluR5

[Term]
id: IMR:0001751
name: GRM5_RAT
exact_synonym: "glutamate receptor, metabotropic 5" [RGD:2746]
exact_synonym: "Gprc1e" [UniProt:P31424]
exact_synonym: "Grm5" [RGD:2746, UniProt:P31424]
exact_synonym: "Metabotropic glutamate receptor 5" [UniProt:P31424]
exact_synonym: "Mglur5" [UniProt:P31424]
exact_synonym: "mGluR5" [UniProt:P31424]
xref_analog: UniProt:P31424
relationship: sequence_of IMR:0001731 ! mGluR5

[Term]
id: IMR:0001752
name: GRM6_HUMAN
exact_synonym: "glutamate receptor, metabotropic 6" [HGNC:4598]
exact_synonym: "GLUTAMATE RECEPTOR, METABOTROPIC, 6" [MIM:604096]
exact_synonym: "GPRC1F" [HGNC:4598, UniProt:O15303]
exact_synonym: "GRM6" [HGNC:4598, UniProt:O15303, MIM:604096]
exact_synonym: "Metabotropic glutamate receptor 6" [UniProt:O15303]
exact_synonym: "mGlu6" [HGNC:4598]
exact_synonym: "MGLUR6" [HGNC:4598, UniProt:O15303, MIM:604096]
exact_synonym: "mGluR6" [UniProt:O15303]
xref_analog: UniProt:O15303
relationship: sequence_of IMR:0001737 ! mGluR6

[Term]
id: IMR:0001753
name: GRM6_MOUSE
exact_synonym: "glutamate receptor, metabotropic 6" [MGI:1351343]
exact_synonym: "Gprc1f" [UniProt:Q5NCH9]
exact_synonym: "Grm6" [MGI:1351343, UniProt:Q5NCH9]
exact_synonym: "Metabotropic glutamate receptor 6" [UniProt:Q5NCH9]
exact_synonym: "Mglur6" [UniProt:Q5NCH9]
exact_synonym: "mGluR6" [MGI:1351343, UniProt:Q5NCH9]
exact_synonym: "nerg1" [MGI:1351343]
exact_synonym: "nob2" [MGI:1351343]
exact_synonym: "nob3" [MGI:1351343]
xref_analog: UniProt:Q5NCH9
relationship: sequence_of IMR:0001737 ! mGluR6

[Term]
id: IMR:0001754
name: GRM6_RAT
exact_synonym: "glutamate receptor, metabotropic 6" [RGD:2747]
exact_synonym: "Gprc1f" [UniProt:P35349]
exact_synonym: "Grm6" [UniProt:P35349, RGD:2747]
exact_synonym: "Metabotropic glutamate receptor 6" [UniProt:P35349]
exact_synonym: "Mglur6" [UniProt:P35349]
exact_synonym: "mGluR6" [UniProt:P35349]
xref_analog: UniProt:P35349
relationship: sequence_of IMR:0001737 ! mGluR6

[Term]
id: IMR:0001755
name: GRM7_HUMAN
exact_synonym: "FLJ40498" [EntrezGene:2917]
exact_synonym: "GLUR7" [HGNC:4599, EntrezGene:2917]
exact_synonym: "glutamate receptor, metabotropic 7" [HGNC:4599, EntrezGene:2917]
exact_synonym: "GLUTAMATE RECEPTOR, METABOTROPIC, 7" [MIM:604101]
exact_synonym: "GPRC1G" [HGNC:4599, EntrezGene:2917, UniProt:Q14831]
exact_synonym: "GRM7" [HGNC:4599, MIM:604101, EntrezGene:2917, UniProt:Q14831]
exact_synonym: "Metabotropic glutamate receptor 7" [UniProt:Q14831]
exact_synonym: "mGlu7" [HGNC:4599]
exact_synonym: "MGLU7" [EntrezGene:2917]
exact_synonym: "MGLUR7" [HGNC:4599, MIM:604101, EntrezGene:2917, UniProt:Q14831]
exact_synonym: "mGluR7" [UniProt:Q14831]
xref_analog: UniProt:Q14831
relationship: sequence_of IMR:0001738 ! mGluR7

[Term]
id: IMR:0001756
name: GRM7_MOUSE
exact_synonym: "glutamate receptor, metabotropic 7" [MGI:1351344]
exact_synonym: "Gpr1g" [MGI:1351344]
exact_synonym: "Gprc1g" [UniProt:Q68ED2]
exact_synonym: "Grm7" [UniProt:Q68ED2, MGI:1351344]
exact_synonym: "Metabotropic glutamate receptor 7" [UniProt:Q68ED2]
exact_synonym: "mGlu7a receptor" [MGI:1351344]
exact_synonym: "Mglur7" [UniProt:Q68ED2]
exact_synonym: "mGluR7" [UniProt:Q68ED2, MGI:1351344]
xref_analog: UniProt:Q68ED2
relationship: sequence_of IMR:0001738 ! mGluR7

[Term]
id: IMR:0001757
name: GRM7_RAT
exact_synonym: "glutamate receptor, metabotropic 7" [RGD:619857]
exact_synonym: "Gprc1g" [UniProt:P35400]
exact_synonym: "Grm7" [UniProt:P35400, RGD:619857]
exact_synonym: "Metabotropic glutamate receptor 7" [UniProt:P35400]
exact_synonym: "Mglur7" [UniProt:P35400]
exact_synonym: "mGluR7" [UniProt:P35400]
xref_analog: UniProt:P35400
relationship: sequence_of IMR:0001738 ! mGluR7

[Term]
id: IMR:0001758
name: GRM8_HUMAN
exact_synonym: "GLUR8" [HGNC:4600]
exact_synonym: "glutamate receptor, metabotropic 8" [HGNC:4600]
exact_synonym: "GLUTAMATE RECEPTOR, METABOTROPIC, 8" [MIM:601116]
exact_synonym: "GPRC1H" [UniProt:O00222, HGNC:4600]
exact_synonym: "GRM8" [UniProt:O00222, HGNC:4600, MIM:601116]
exact_synonym: "Metabotropic glutamate receptor 8" [UniProt:O00222]
exact_synonym: "mGlu8" [HGNC:4600]
exact_synonym: "MGLUR8" [UniProt:O00222, HGNC:4600, MIM:601116]
exact_synonym: "mGluR8" [UniProt:O00222]
xref_analog: UniProt:O00222
relationship: sequence_of IMR:0001739 ! mGluR8

[Term]
id: IMR:0001759
name: GRM8_MOUSE
exact_synonym: "glutamate receptor, metabotropic 8" [MGI:1351345]
exact_synonym: "Gprc1h" [UniProt:P47743, MGI:1351345]
exact_synonym: "Grm8" [UniProt:P47743, MGI:1351345]
exact_synonym: "Metabotropic glutamate receptor 8" [UniProt:P47743]
exact_synonym: "Mglur8" [UniProt:P47743]
exact_synonym: "mGluR8" [UniProt:P47743, MGI:1351345]
xref_analog: UniProt:P47743
relationship: sequence_of IMR:0001739 ! mGluR8

[Term]
id: IMR:0001760
name: GRM8_RAT
exact_synonym: "glutamate receptor, metabotropic 8" [RGD:619858]
exact_synonym: "Gprc1h" [UniProt:P70579]
exact_synonym: "Grm8" [RGD:619858, UniProt:P70579]
exact_synonym: "Metabotropic glutamate receptor 8" [UniProt:P70579]
exact_synonym: "Mglur8" [UniProt:P70579]
exact_synonym: "mGluR8" [UniProt:P70579]
xref_analog: UniProt:P70579
relationship: sequence_of IMR:0001739 ! mGluR8

[Term]
id: IMR:0001761
name: D1-like receptor
exact_synonym: "D1-like dopamine receptor" []
exact_synonym: "dopamine D1-like receptor" []
is_a: IMR:0000138 ! Rhodopsin-like GPCR(typeA)

[Term]
id: IMR:0001762
name: D2-like receptor
exact_synonym: "D1-like dopamine receptor" []
exact_synonym: "dopamine D2-like receptor" []
is_a: IMR:0000138 ! Rhodopsin-like GPCR(typeA)

[Term]
id: IMR:0001763
name: DARPP-32
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0001764
name: D1 receptor
exact_synonym: "D1 dopamine receptor" []
exact_synonym: "dopamine D1 receptor" []
is_a: IMR:0001761 ! D1-like receptor

[Term]
id: IMR:0001765
name: D5 receptor
exact_synonym: "D5 dopamine receptor" []
exact_synonym: "dopamine D5 receptor" []
is_a: IMR:0001761 ! D1-like receptor

[Term]
id: IMR:0001766
name: D2 receptor
exact_synonym: "D2 dopamine receptor" []
exact_synonym: "dopamine D2 receptor" []
is_a: IMR:0001762 ! D2-like receptor

[Term]
id: IMR:0001767
name: D3 receptor
exact_synonym: "D3 dopamine receptor" []
exact_synonym: "dopamine D3 receptor" []
is_a: IMR:0001762 ! D2-like receptor

[Term]
id: IMR:0001768
name: D4 receptor
exact_synonym: "D4 dopamine receptor" []
exact_synonym: "dopamine D4 receptor" []
is_a: IMR:0001762 ! D2-like receptor

[Term]
id: IMR:0001769
name: DRD1_HUMAN
exact_synonym: "D(1A) dopamine receptor" [UniProt:P21728]
exact_synonym: "DADR" [EntrezGene:1812]
exact_synonym: "Dopamine D1 receptor" [UniProt:P21728]
exact_synonym: "dopamine receptor D1" [HGNC:3020, EntrezGene:1812, MIM:126449]
exact_synonym: "DOPAMINE RECEPTOR D1A" [MIM:126449]
exact_synonym: "DRD1" [HGNC:3020, EntrezGene:1812, UniProt:P21728, MIM:126449]
exact_synonym: "DRD1A" [EntrezGene:1812, MIM:126449]
xref_analog: UniProt:P21728
relationship: sequence_of IMR:0001764 ! D1 receptor

[Term]
id: IMR:0001770
name: DRD1_MOUSE
exact_synonym: "D(1A) dopamine receptor" [UniProt:Q61616]
exact_synonym: "D1 receptor" [MGI:99578]
exact_synonym: "Dopamine D1 receptor" [UniProt:Q61616]
exact_synonym: "dopamine receptor D1A" [MGI:99578]
exact_synonym: "Drd-1" [MGI:99578]
exact_synonym: "Drd1" [MGI:99578, UniProt:Q61616]
exact_synonym: "Drd1a" [MGI:99578, UniProt:Q61616]
exact_synonym: "Gpcr15" [MGI:99578, UniProt:Q61616]
xref_analog: UniProt:Q61616
relationship: sequence_of IMR:0001764 ! D1 receptor

[Term]
id: IMR:0001771
name: DRD1_RAT
exact_synonym: "D(1A) dopamine receptor" [UniProt:P18901]
exact_synonym: "Dopamine D1 receptor" [UniProt:P18901]
exact_synonym: "dopamine receptor D1A" [RGD:2518]
exact_synonym: "Drd1" [UniProt:P18901]
exact_synonym: "Drd1a" [UniProt:P18901, RGD:2518]
xref_analog: UniProt:P18901
relationship: sequence_of IMR:0001764 ! D1 receptor

[Term]
id: IMR:0001772
name: DRD2_HUMAN
exact_synonym: "D(2) dopamine receptor" [UniProt:P14416]
exact_synonym: "D2DR" [EntrezGene:1813]
exact_synonym: "D2R" [EntrezGene:1813, MIM:126450]
exact_synonym: "Dopamine D2 receptor" [UniProt:P14416]
exact_synonym: "dopamine receptor D2" [EntrezGene:1813, HGNC:3023, MIM:126450]
exact_synonym: "DRD2" [EntrezGene:1813, HGNC:3023, MIM:126450, UniProt:P14416]
xref_analog: UniProt:P14416
relationship: sequence_of IMR:0001766 ! D2 receptor

[Term]
id: IMR:0001773
name: DRD2_MOUSE
exact_synonym: "D(2) dopamine receptor" [UniProt:P61168]
exact_synonym: "D2 receptor" [MGI:94924]
exact_synonym: "D2R" [MGI:94924]
exact_synonym: "Dopamine D2 receptor" [UniProt:P61168]
exact_synonym: "dopamine receptor D2" [MGI:94924]
exact_synonym: "Drd-2" [MGI:94924]
exact_synonym: "Drd2" [MGI:94924, UniProt:P61168]
xref_analog: UniProt:P61168
relationship: sequence_of IMR:0001766 ! D2 receptor

[Term]
id: IMR:0001774
name: DRD2_RAT
exact_synonym: "D(2) dopamine receptor" [UniProt:P61169]
exact_synonym: "Dopamine D2 receptor" [UniProt:P61169]
exact_synonym: "dopamine receptor D2" [RGD:2520]
exact_synonym: "Drd2" [UniProt:P61169, RGD:2520]
xref_analog: UniProt:P61169
relationship: sequence_of IMR:0001766 ! D2 receptor

[Term]
id: IMR:0001775
name: DRD3_HUMAN
exact_synonym: "D(3) dopamine receptor" [UniProt:P35462]
exact_synonym: "D3DR" [EntrezGene:1814]
exact_synonym: "Dopamine D3 receptor" [UniProt:P35462]
exact_synonym: "dopamine receptor D3" [EntrezGene:1814, MIM:126451, HGNC:3024]
exact_synonym: "DRD3" [EntrezGene:1814, UniProt:P35462, MIM:126451, HGNC:3024]
exact_synonym: "ETM1" [EntrezGene:1814]
exact_synonym: "FET1" [EntrezGene:1814]
exact_synonym: "MGC149204" [EntrezGene:1814]
exact_synonym: "MGC149205" [EntrezGene:1814]
xref_analog: UniProt:P35462
relationship: sequence_of IMR:0001767 ! D3 receptor

[Term]
id: IMR:0001776
name: DRD3_MOUSE
exact_synonym: "D(3) dopamine receptor" [UniProt:P30728]
exact_synonym: "D3 receptor" [MGI:94925]
exact_synonym: "D3R" [MGI:94925]
exact_synonym: "Dopamine D3 receptor" [UniProt:P30728]
exact_synonym: "dopamine receptor D3" [MGI:94925]
exact_synonym: "Drd3" [MGI:94925, UniProt:P30728]
xref_analog: UniProt:P30728
relationship: sequence_of IMR:0001767 ! D3 receptor

[Term]
id: IMR:0001777
name: DRD3_RAT
exact_synonym: "D(3) dopamine receptor" [UniProt:P19020]
exact_synonym: "Dopamine D3 receptor" [UniProt:P19020]
exact_synonym: "dopamine receptor D3" [RGD:2521]
exact_synonym: "Drd3" [RGD:2521, UniProt:P19020]
xref_analog: UniProt:P19020
relationship: sequence_of IMR:0001767 ! D3 receptor

[Term]
id: IMR:0001778
name: DRD4_HUMAN
exact_synonym: "D(2C) dopamine receptor" [UniProt:P21917]
exact_synonym: "D(4) dopamine receptor" [UniProt:P21917]
exact_synonym: "D4DR" [EntrezGene:1815, MIM:126452]
exact_synonym: "Dopamine D4 receptor" [UniProt:P21917]
exact_synonym: "dopamine receptor D4" [EntrezGene:1815, HGNC:3025, MIM:126452]
exact_synonym: "DRD4" [UniProt:P21917, EntrezGene:1815, HGNC:3025, MIM:126452]
xref_analog: UniProt:P21917
relationship: sequence_of IMR:0001768 ! D4 receptor

[Term]
id: IMR:0001779
name: DRD4_MOUSE
exact_synonym: "D(2C) dopamine receptor" [UniProt:P51436]
exact_synonym: "D(4) dopamine receptor" [UniProt:P51436]
exact_synonym: "D4R" [MGI:94926]
exact_synonym: "Dopamine D4 receptor" [UniProt:P51436]
exact_synonym: "dopamine receptor D4" [MGI:94926]
exact_synonym: "Drd-4" [MGI:94926]
exact_synonym: "Drd4" [UniProt:P51436, MGI:94926]
xref_analog: UniProt:P51436
relationship: sequence_of IMR:0001768 ! D4 receptor

[Term]
id: IMR:0001780
name: DRD4_RAT
exact_synonym: "D(2C) dopamine receptor" [UniProt:P30729]
exact_synonym: "D(4) dopamine receptor" [UniProt:P30729]
exact_synonym: "Dopamine D4 receptor" [UniProt:P30729]
exact_synonym: "dopamine receptor D4" [RGD:2522]
exact_synonym: "Drd4" [UniProt:P30729, RGD:2522]
xref_analog: UniProt:P30729
relationship: sequence_of IMR:0001768 ! D4 receptor

[Term]
id: IMR:0001781
name: DRD5_HUMAN
exact_synonym: "D(1B) dopamine receptor" [UniProt:P21918]
exact_synonym: "D(5) dopamine receptor" [UniProt:P21918]
exact_synonym: "D1beta dopamine receptor" [UniProt:P21918]
exact_synonym: "Dopamine D5 receptor" [UniProt:P21918]
exact_synonym: "dopamine receptor D5" [HGNC:3026]
exact_synonym: "DRD1B" [UniProt:P21918, HGNC:3026]
exact_synonym: "DRD1L2" [UniProt:P21918]
exact_synonym: "DRD5" [UniProt:P21918, HGNC:3026]
xref_analog: UniProt:P21918
relationship: sequence_of IMR:0001765 ! D5 receptor

[Term]
id: IMR:0001782
name: DRD5_MOUSE
exact_synonym: "D(1B) dopamine receptor" [UniProt:Q8BLD9]
exact_synonym: "D(5) dopamine receptor" [UniProt:Q8BLD9]
exact_synonym: "D5R" [MGI:94927]
exact_synonym: "Dopamine D5 receptor" [UniProt:Q8BLD9]
exact_synonym: "dopamine receptor D5" [MGI:94927]
exact_synonym: "Drd-5" [MGI:94927]
exact_synonym: "DRD1b" [MGI:94927]
exact_synonym: "Drd1b" [MGI:94927]
exact_synonym: "Drd5" [UniProt:Q8BLD9, MGI:94927]
exact_synonym: "Gpcr1" [MGI:94927]
xref_analog: UniProt:Q8BLD9
relationship: sequence_of IMR:0001765 ! D5 receptor

[Term]
id: IMR:0001783
name: DRD5_RAT
exact_synonym: "D(1B) dopamine receptor" [UniProt:P25115]
exact_synonym: "D(5) dopamine receptor" [UniProt:P25115]
exact_synonym: "Dopamine D5 receptor" [UniProt:P25115]
exact_synonym: "dopamine receptor D5" [RGD:2523]
exact_synonym: "Drd5" [RGD:2523, UniProt:P25115]
xref_analog: UniProt:P25115
relationship: sequence_of IMR:0001765 ! D5 receptor

[Term]
id: IMR:0001784
name: peptidoglycan recognition protein
def: "Peptidoglycan recognition proteins (PGRPs) are pattern recognition molecules that are conserved from insects to mammals and recognize bacteria and their unique cell wall component, peptidoglycan (PGN). Drosophila, mosquito, and mammals have families of 13, 7, and 4 PGRP genes, respectively, and some of these genes are alternatively spliced." [PubMed:14698226]
exact_synonym: "PGRP" []
is_a: IMR:0001791 ! pattern recognition receptor

[Term]
id: IMR:0001785
name: PGPSA_DROME
exact_synonym: "BcDNA:AT30827" [FlyBase:FBgn0030310]
exact_synonym: "CG11709" [FlyBase:FBgn0030310]
exact_synonym: "EC 3.4.17.13" [UniProt:Q9VYX7]
exact_synonym: "Peptidoglycan recognition protein SA" [FlyBase:FBgn0030310]
exact_synonym: "Peptidoglycan-recognition protein SA" [UniProt:Q9VYX7]
exact_synonym: "PGRP-SA" [FlyBase:FBgn0030310, UniProt:Q9VYX7]
exact_synonym: "Protein semmelweis" [UniProt:Q9VYX7]
exact_synonym: "seml" [FlyBase:FBgn0030310, UniProt:Q9VYX7]
exact_synonym: "SEMMELWEIS" [FlyBase:FBgn0030310]
exact_synonym: "semmelweis" [FlyBase:FBgn0030310]
exact_synonym: "semmelweiss" [FlyBase:FBgn0030310]
xref_analog: UniProt:Q9VYX7
relationship: sequence_of IMR:0001784 ! peptidoglycan recognition protein

[Term]
id: IMR:0001786
name: PGPSD_DROME
exact_synonym: "CG7496" [FlyBase:FBgn0035806]
exact_synonym: "Peptidoglycan-recognition protein SD" [UniProt:Q9VS97]
exact_synonym: "PGRP-SD" [FlyBase:FBgn0035806, UniProt:Q9VS97]
xref_analog: UniProt:Q9VS97
relationship: sequence_of IMR:0001784 ! peptidoglycan recognition protein

[Term]
id: IMR:0001787
name: PGPLC_DROME
exact_synonym: "CG4432" [FlyBase:FBgn0035976]
exact_synonym: "immune response deficient 7" [FlyBase:FBgn0035976]
exact_synonym: "Immune response deficient 7 protein" [UniProt:Q9GNK5]
exact_synonym: "ird7" [FlyBase:FBgn0035976, UniProt:Q9GNK5]
exact_synonym: "Peptidoglycan recognition protein LC" [FlyBase:FBgn0035976]
exact_synonym: "Peptidoglycan-recognition protein LC" [UniProt:Q9GNK5]
exact_synonym: "PGRP-LC" [FlyBase:FBgn0035976, UniProt:Q9GNK5]
exact_synonym: "PGRP-LCx" [FlyBase:FBgn0035976]
exact_synonym: "PGRPLC" [UniProt:Q9GNK5]
exact_synonym: "tot" [FlyBase:FBgn0035976]
exact_synonym: "totem" [FlyBase:FBgn0035976]
xref_analog: UniProt:Q9GNK5
relationship: sequence_of IMR:0001784 ! peptidoglycan recognition protein

[Term]
id: IMR:0001788
name: PGPLE_DROME
exact_synonym: "anon-WO0153538.66" [FlyBase:FBgn0030695]
exact_synonym: "CG8995" [FlyBase:FBgn0030695]
exact_synonym: "Peptidoglycan recognition protein LE" [FlyBase:FBgn0030695]
exact_synonym: "Peptidoglycan-recognition protein LE" [UniProt:Q9VXN9]
exact_synonym: "PGRP-LE" [FlyBase:FBgn0030695, UniProt:Q9VXN9]
xref_analog: UniProt:Q9VXN9
relationship: sequence_of IMR:0001784 ! peptidoglycan recognition protein

[Term]
id: IMR:0001789
name: beta-1,3-glucan
def: "component of fungal cell walls." [MeSH:C033363]
exact_synonym: "(1 --> 3)-beta-D-glucan" []
exact_synonym: "(1,3)-beta-D-glucan" []
exact_synonym: "(1-->3)-beta-D-glucan" []
exact_synonym: "(1->3)-beta-D-glucan" []
exact_synonym: "beta-1,3-D-glucan" []
xref_analog: MeSH:C033363
is_a: IMR:0000965 ! chemical ligand
is_a: IMR:0001790 ! polysaccharide

[Term]
id: IMR:0001790
name: polysaccharide
is_a: IMR:0001657 ! carbohydrate

[Term]
id: IMR:0001791
name: pattern recognition receptor
def: "Receptors of the innate immune system that recognize pathogen associated molecular patterns (PAMPs, e.g. LPS) are called pattern recognition receptors (PRRs)." [PubMed:11724812, PubMed:16697918]
exact_synonym: "PRR" []
xref_analog: GO:0008329
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0001792
name: Gram-negative bacteria binding protein
def: "Drosophila possesses at least three cDNAs encoding members of the Gram-negative bacteria-binding protein (DGNBP) family." [PubMed:10827089]
exact_synonym: "GNBP" []
is_a: IMR:0001791 ! pattern recognition receptor

[Term]
id: IMR:0001793
name: BGBP1_DROME
exact_synonym: "CG6895" [FlyBase:FBgn0040323]
exact_synonym: "DGNBP-1" [FlyBase:FBgn0040323]
exact_synonym: "DGNBP1" [FlyBase:FBgn0040323]
exact_synonym: "GNBP" [FlyBase:FBgn0040323]
exact_synonym: "GNBP1" [FlyBase:FBgn0040323, UniProt:Q9NHB0]
exact_synonym: "Gram-negative bacteria binding protein 1" [FlyBase:FBgn0040323]
exact_synonym: "Gram-negative bacteria-binding protein 1" [UniProt:Q9NHB0]
exact_synonym: "osiris" [FlyBase:FBgn0040323]
xref_analog: UniProt:Q9NHB0
relationship: sequence_of IMR:0001792 ! Gram-negative bacteria binding protein

[Term]
id: IMR:0001794
name: BGBP2_DROME
exact_synonym: "CG4144" [FlyBase:FBgn0040322]
exact_synonym: "DGNBP-2" [FlyBase:FBgn0040322]
exact_synonym: "GNBP" [FlyBase:FBgn0040322]
exact_synonym: "GNBP2" [UniProt:Q9VVR4, FlyBase:FBgn0040322]
exact_synonym: "Gram-negative bacteria binding protein 2" [FlyBase:FBgn0040322]
exact_synonym: "Gram-negative bacteria-binding protein 2" [UniProt:Q9VVR4]
xref_analog: UniProt:Q9VVR4
relationship: sequence_of IMR:0001792 ! Gram-negative bacteria binding protein

[Term]
id: IMR:0001795
name: BGBP3_DROME
exact_synonym: "CG5008" [FlyBase:FBgn0040321]
exact_synonym: "DGNBP-3" [FlyBase:FBgn0040321]
exact_synonym: "GNBP" [FlyBase:FBgn0040321]
exact_synonym: "GNBP3" [FlyBase:FBgn0040321, UniProt:Q9NHA8]
exact_synonym: "Gram-negative bacteria binding protein 3" [FlyBase:FBgn0040321]
exact_synonym: "Gram-negative bacteria-binding protein 3" [UniProt:Q9NHA8]
exact_synonym: "Hades" [FlyBase:FBgn0040321]
xref_analog: UniProt:Q9NHA8
relationship: sequence_of IMR:0001792 ! Gram-negative bacteria binding protein

[Term]
id: IMR:0001796
name: PSH_DROME
exact_synonym: "c-SP28" [FlyBase:FBgn0030926]
exact_synonym: "CG6367" [FlyBase:FBgn0030926]
exact_synonym: "EC 3.4.21.-" [UniProt:Q9VWU1]
exact_synonym: "persephone" [FlyBase:FBgn0030926]
exact_synonym: "psh" [FlyBase:FBgn0030926, UniProt:Q9VWU1]
exact_synonym: "Serine protease persephone" [UniProt:Q9VWU1]
exact_synonym: "SP28" [FlyBase:FBgn0030926]
xref_analog: UniProt:Q9VWU1
relationship: sequence_of IMR:0000304 ! protease

[Term]
id: IMR:0001797
name: Q9U5W7_DROME
exact_synonym: "anon-WO0118057.3" [FlyBase:FBgn0002930]
exact_synonym: "CG1857" [FlyBase:FBgn0002930]
exact_synonym: "nec" [FlyBase:FBgn0002930, UniProt:Q9U5W7]
exact_synonym: "necrotic" [FlyBase:FBgn0002930]
exact_synonym: "Ser3" [FlyBase:FBgn0002930]
exact_synonym: "SER3" [FlyBase:FBgn0002930]
exact_synonym: "Serine protease inhibitor 3" [FlyBase:FBgn0002930]
exact_synonym: "Serpin, putative" [UniProt:Q9U5W7]
exact_synonym: "serpin43Ac" [FlyBase:FBgn0002930]
exact_synonym: "Spn43Ac" [FlyBase:FBgn0002930, UniProt:Q9U5W7]
xref_analog: UniProt:Q9U5W7
relationship: sequence_of IMR:0000429 ! enzyme regulator

[Term]
id: IMR:0001798
name: SPZ_DROME
exact_synonym: "CG6134" [FlyBase:FBgn0003495]
exact_synonym: "mel(3)7" [FlyBase:FBgn0003495]
exact_synonym: "Protein spaetzle" [UniProt:P48607]
exact_synonym: "Protein spaetzle C-106" [UniProt:P48607]
exact_synonym: "spaetzle" [FlyBase:FBgn0003495]
exact_synonym: "Spaetzle" [FlyBase:FBgn0003495]
exact_synonym: "Spatzle" [FlyBase:FBgn0003495]
exact_synonym: "spatzle" [FlyBase:FBgn0003495]
exact_synonym: "spz" [UniProt:P48607, FlyBase:FBgn0003495]
xref_analog: UniProt:P48607
relationship: sequence_of IMR:0000002 ! ligand

[Term]
id: IMR:0001799
name: TUBE_DROME
def: "Tube has no obvious mammalian homologue." [PubMed:12495727, PubMed:14603309]
exact_synonym: "CG10520" [FlyBase:FBgn0003882]
exact_synonym: "Protein Tube" [UniProt:P22812]
exact_synonym: "tub" [UniProt:P22812, FlyBase:FBgn0003882]
exact_synonym: "tube" [UniProt:P22812, FlyBase:FBgn0003882]
xref_analog: UniProt:P22812
relationship: sequence_of IMR:0000742 ! DD-containing adaptor protein

[Term]
id: IMR:0001800
name: Q9V566_DROME
xref_analog: UniProt:Q9V566
relationship: sequence_of IMR:0100465 ! MyD88

[Term]
id: IMR:0001801
name: Q9XYQ9_DROME
exact_synonym: "TNF-receptor-associated factor 2" [UniProt:Q9XYQ9]
exact_synonym: "TNF-receptor-associated factor 6" [FlyBase:FBgn0026318]
exact_synonym: "Traf2" [UniProt:Q9XYQ9]
exact_synonym: "TRAF2" [UniProt:Q9XYQ9]
exact_synonym: "Traf6" [UniProt:Q9XYQ9, FlyBase:FBgn0026318]
xref_analog: UniProt:Q9XYQ9
relationship: sequence_of IMR:0000462 ! TRAF family

[Term]
id: IMR:0001802
name: KPEL_DROME
exact_synonym: "CG5974" [FlyBase:FBgn0010441]
exact_synonym: "EC 2.7.11.1" [UniProt:Q05652]
exact_synonym: "p11" [FlyBase:FBgn0010441]
exact_synonym: "pelle" [FlyBase:FBgn0010441]
exact_synonym: "PELLE/IL-1" [FlyBase:FBgn0010441]
exact_synonym: "pll" [UniProt:Q05652, FlyBase:FBgn0010441]
exact_synonym: "Serine/threonine-protein kinase pelle" [UniProt:Q05652]
xref_analog: UniProt:Q05652
relationship: sequence_of IMR:0100488 ! IRAK

[Term]
id: IMR:0001803
name: REF2P_DROME
exact_synonym: "CG10360" [FlyBase:FBgn0003231]
exact_synonym: "Protein ref(2)P" [UniProt:P14199]
exact_synonym: "ref" [FlyBase:FBgn0003231]
exact_synonym: "ref(2)P" [UniProt:P14199, FlyBase:FBgn0003231]
exact_synonym: "Ref(2)P" [FlyBase:FBgn0003231]
exact_synonym: "Ref(2)p" [FlyBase:FBgn0003231]
exact_synonym: "ref(2)p" [FlyBase:FBgn0003231]
exact_synonym: "ref(2)Pn" [FlyBase:FBgn0003231]
exact_synonym: "ref(2)Po2" [FlyBase:FBgn0003231]
exact_synonym: "Ref2P" [FlyBase:FBgn0003231]
exact_synonym: "ref2p" [FlyBase:FBgn0003231]
exact_synonym: "refractaire" [FlyBase:FBgn0003231]
exact_synonym: "refractaire(2)Paris" [FlyBase:FBgn0003231]
exact_synonym: "Refractory to sigma P" [UniProt:P14199]
exact_synonym: "refractory to sigma P" [FlyBase:FBgn0003231]
xref_analog: UniProt:P14199
relationship: sequence_of IMR:0000556 ! unclassified protein

[Term]
id: IMR:0001804
name: Q9GSZ3_DROME
exact_synonym: "aPKC" [UniProt:Q9GSZ3, FlyBase:FBgn0261854]
exact_synonym: "apkc" [FlyBase:FBgn0261854]
exact_synonym: "aPKC-zeta" [FlyBase:FBgn0261854]
exact_synonym: "Atypical protein kinase C" [UniProt:Q9GSZ3]
exact_synonym: "atypical protein kinase C" [FlyBase:FBgn0261854]
exact_synonym: "CG10261" [FlyBase:FBgn0261854]
exact_synonym: "DaPKC" [FlyBase:FBgn0261854]
exact_synonym: "dapkc" [FlyBase:FBgn0261854]
exact_synonym: "l(2)k06403" [FlyBase:FBgn0261854]
exact_synonym: "pkc-3" [FlyBase:FBgn0261854]
exact_synonym: "PKCl,i" [FlyBase:FBgn0261854]
exact_synonym: "pschur" [FlyBase:FBgn0261854]
exact_synonym: "psu" [FlyBase:FBgn0261854]
xref_analog: UniProt:Q9GSZ3
relationship: sequence_of IMR:0000245 ! PKC

[Term]
id: IMR:0001805
name: CACT_DROME
exact_synonym: "BG:DS02740.15" [FlyBase:FBgn0000250]
exact_synonym: "cac" [FlyBase:FBgn0000250]
exact_synonym: "cact" [FlyBase:FBgn0000250, UniProt:Q03017]
exact_synonym: "CACT" [FlyBase:FBgn0000250]
exact_synonym: "cactus" [FlyBase:FBgn0000250]
exact_synonym: "CG5848" [FlyBase:FBgn0000250]
exact_synonym: "dip6" [FlyBase:FBgn0000250]
exact_synonym: "female-sterile-(2)-ltoRN48" [FlyBase:FBgn0000250]
exact_synonym: "fs(2)ltoRN48" [FlyBase:FBgn0000250]
exact_synonym: "n(2)k17003" [FlyBase:FBgn0000250]
exact_synonym: "NF-kappa-B inhibitor cactus" [UniProt:Q03017]
xref_analog: UniProt:Q03017
relationship: sequence_of IMR:0000463 ! I-kappaB family

[Term]
id: IMR:0001806
name: DIF_DROME
exact_synonym: "CG6794" [FlyBase:FBgn0011274]
exact_synonym: "Dif" [FlyBase:FBgn0011274, UniProt:P98149]
exact_synonym: "DIF" [FlyBase:FBgn0011274]
exact_synonym: "dif" [FlyBase:FBgn0011274]
exact_synonym: "Dorsal-related immunity factor" [FlyBase:FBgn0011274]
exact_synonym: "Dorsal-related immunity factor Dif" [UniProt:P98149]
xref_analog: UniProt:P98149
relationship: sequence_of IMR:0000382 ! NF-kappaB

[Term]
id: IMR:0001807
name: DORS_DROME
exact_synonym: "anon-EST:GressD7" [FlyBase:FBgn0260632]
exact_synonym: "CG6667" [FlyBase:FBgn0260632]
exact_synonym: "dl" [FlyBase:FBgn0260632, UniProt:P15330]
exact_synonym: "dL" [FlyBase:FBgn0260632]
exact_synonym: "dorsal" [FlyBase:FBgn0260632]
exact_synonym: "Embryonic polarity protein dorsal" [UniProt:P15330]
exact_synonym: "fs(2)k10816" [FlyBase:FBgn0260632]
exact_synonym: "mat(2)dorsal" [FlyBase:FBgn0260632]
xref_analog: UniProt:P15330
relationship: sequence_of IMR:0000382 ! NF-kappaB

[Term]
id: IMR:0001808
name: Q9NHG0_DROME
def: "The imd gene product has a Death domain similar to the one in human receptor-interacting protein (RIP) kinase but lacks a kinase domain." [PubMed:12495727, PubMed:14603309]
exact_synonym: "anon-WO0172774.166" [FlyBase:FBgn0013983]
exact_synonym: "BG5" [FlyBase:FBgn0013983]
exact_synonym: "CG5576" [FlyBase:FBgn0013983]
exact_synonym: "Death-domain containing protein BG5" [UniProt:Q9NHG0]
exact_synonym: "imd" [UniProt:Q9NHG0, FlyBase:FBgn0013983]
exact_synonym: "Imd" [FlyBase:FBgn0013983]
exact_synonym: "IMD" [FlyBase:FBgn0013983]
exact_synonym: "immune deficiency" [FlyBase:FBgn0013983]
exact_synonym: "Immunodeficiency" [FlyBase:FBgn0013983]
exact_synonym: "shadok" [FlyBase:FBgn0013983]
xref_analog: UniProt:Q9NHG0
relationship: sequence_of IMR:0000556 ! unclassified protein

[Term]
id: IMR:0001809
name: BG4_DROME
exact_synonym: "BG4" [FlyBase:FBgn0038928, UniProt:Q9V3B4]
exact_synonym: "CG12297" [FlyBase:FBgn0038928]
exact_synonym: "Death domain-containing adapter protein BG4" [UniProt:Q9V3B4]
exact_synonym: "dFADD" [FlyBase:FBgn0038928, UniProt:Q9V3B4]
exact_synonym: "dFadd" [FlyBase:FBgn0038928]
exact_synonym: "Fadd" [FlyBase:FBgn0038928]
exact_synonym: "FADD" [FlyBase:FBgn0038928]
exact_synonym: "FAS-associated death domain-containing protein" [UniProt:Q9V3B4]
xref_analog: UniProt:Q9V3B4
relationship: sequence_of IMR:0100463 ! FADD

[Term]
id: IMR:0001810
name: M3K7_DROME
exact_synonym: "CG1388" [FlyBase:FBgn0026323]
exact_synonym: "CG18492" [FlyBase:FBgn0026323]
exact_synonym: "D-tak" [FlyBase:FBgn0026323]
exact_synonym: "D10" [FlyBase:FBgn0026323]
exact_synonym: "DmTak1" [FlyBase:FBgn0026323]
exact_synonym: "dTAK" [FlyBase:FBgn0026323]
exact_synonym: "DTak" [FlyBase:FBgn0026323]
exact_synonym: "dTAK1" [UniProt:Q9V3Q6, FlyBase:FBgn0026323]
exact_synonym: "DTak1" [FlyBase:FBgn0026323]
exact_synonym: "dTak1" [FlyBase:FBgn0026323]
exact_synonym: "DTAK1" [FlyBase:FBgn0026323]
exact_synonym: "EC 2.7.11.25" [UniProt:Q9V3Q6]
exact_synonym: "Mitogen-activated protein kinase kinase kinase 7" [UniProt:Q9V3Q6]
exact_synonym: "tak" [FlyBase:FBgn0026323]
exact_synonym: "TAK" [FlyBase:FBgn0026323]
exact_synonym: "Tak 1" [FlyBase:FBgn0026323]
exact_synonym: "TAK-1" [FlyBase:FBgn0026323]
exact_synonym: "Tak1" [UniProt:Q9V3Q6, FlyBase:FBgn0026323]
exact_synonym: "tak1" [FlyBase:FBgn0026323]
exact_synonym: "TAK1" [FlyBase:FBgn0026323]
exact_synonym: "TGF-beta activated kinase 1" [FlyBase:FBgn0026323]
exact_synonym: "TGF-beta activated-kinase 1" [FlyBase:FBgn0026323]
exact_synonym: "TGF-beta-activated kinase 1" [UniProt:Q9V3Q6]
xref_analog: UniProt:Q9V3Q6
relationship: sequence_of IMR:0000232 ! TAK1

[Term]
id: IMR:0001811
name: CASP8_DROME
exact_synonym: "anon-1BCa" [FlyBase:FBgn0020381]
exact_synonym: "caspase" [FlyBase:FBgn0020381]
exact_synonym: "Caspase-8" [UniProt:Q8IRY7]
exact_synonym: "Caspase-8 subunit p10" [UniProt:Q8IRY7]
exact_synonym: "Caspase-8 subunit p15" [UniProt:Q8IRY7]
exact_synonym: "Ced-3-like/Nedd2-like protein" [FlyBase:FBgn0020381]
exact_synonym: "CG7486" [FlyBase:FBgn0020381]
exact_synonym: "DCP-2" [FlyBase:FBgn0020381]
exact_synonym: "Dcp-2" [FlyBase:FBgn0020381]
exact_synonym: "dcp-2/dredd" [FlyBase:FBgn0020381]
exact_synonym: "Dcp-2/Dredd" [FlyBase:FBgn0020381]
exact_synonym: "DCP-2/DREDD" [FlyBase:FBgn0020381]
exact_synonym: "DCP2" [UniProt:Q8IRY7, FlyBase:FBgn0020381]
exact_synonym: "Dcp2" [FlyBase:FBgn0020381]
exact_synonym: "Death caspase-2" [FlyBase:FBgn0020381]
exact_synonym: "Death related ced-3/Nedd2-like protein" [FlyBase:FBgn0020381]
exact_synonym: "Death-related ced-3/NEDD2-like protein" [UniProt:Q8IRY7]
exact_synonym: "Dedd" [FlyBase:FBgn0020381]
exact_synonym: "Dredd" [UniProt:Q8IRY7, FlyBase:FBgn0020381]
exact_synonym: "dredd" [FlyBase:FBgn0020381]
exact_synonym: "DREDD" [FlyBase:FBgn0020381]
exact_synonym: "Drosophila caspase" [FlyBase:FBgn0020381]
exact_synonym: "EC 3.4.22.61" [UniProt:Q8IRY7]
exact_synonym: "EG:115C2.9" [FlyBase:FBgn0020381]
exact_synonym: "Redd" [FlyBase:FBgn0020381]
xref_analog: UniProt:Q8IRY7
relationship: sequence_of IMR:0100300 ! caspase-8

[Term]
id: IMR:0001812
name: IKKB_DROME
exact_synonym: "anon-89Bd" [FlyBase:FBgn0024222]
exact_synonym: "cactus kinase" [FlyBase:FBgn0024222]
exact_synonym: "Cactus kinase IKK" [UniProt:Q9VEZ5]
exact_synonym: "CG4201" [FlyBase:FBgn0024222]
exact_synonym: "DIK" [FlyBase:FBgn0024222, UniProt:Q9VEZ5]
exact_synonym: "dIKK" [FlyBase:FBgn0024222]
exact_synonym: "dIKK-beta" [FlyBase:FBgn0024222]
exact_synonym: "DLAK" [FlyBase:FBgn0024222, UniProt:Q9VEZ5]
exact_synonym: "dLak" [FlyBase:FBgn0024222]
exact_synonym: "DmIKK" [FlyBase:FBgn0024222]
exact_synonym: "DmIKK-beta" [UniProt:Q9VEZ5]
exact_synonym: "DmIKKb" [FlyBase:FBgn0024222]
exact_synonym: "DmIKKBeta" [FlyBase:FBgn0024222]
exact_synonym: "dmIKKbeta" [FlyBase:FBgn0024222]
exact_synonym: "DmIKKbeta" [FlyBase:FBgn0024222]
exact_synonym: "DmIkkbeta" [FlyBase:FBgn0024222]
exact_synonym: "Dmikkbeta" [FlyBase:FBgn0024222]
exact_synonym: "EC 2.7.11.10" [UniProt:Q9VEZ5]
exact_synonym: "Ik" [FlyBase:FBgn0024222]
exact_synonym: "IK" [FlyBase:FBgn0024222]
exact_synonym: "ikk" [FlyBase:FBgn0024222]
exact_synonym: "IKK" [FlyBase:FBgn0024222]
exact_synonym: "IKK-beta" [FlyBase:FBgn0024222]
exact_synonym: "IKK-like protein" [FlyBase:FBgn0024222, UniProt:Q9VEZ5]
exact_synonym: "IKKB" [FlyBase:FBgn0024222]
exact_synonym: "immune response deficient 5" [FlyBase:FBgn0024222]
exact_synonym: "Immune response deficient protein 5" [UniProt:Q9VEZ5]
exact_synonym: "Inhibitor of nuclear factor kappa-B kinase subunit beta" [UniProt:Q9VEZ5]
exact_synonym: "ird" [FlyBase:FBgn0024222]
exact_synonym: "Ird-5" [FlyBase:FBgn0024222]
exact_synonym: "ird5" [FlyBase:FBgn0024222, UniProt:Q9VEZ5]
exact_synonym: "ird5/DmIkk[beta]" [FlyBase:FBgn0024222]
exact_synonym: "Lak" [FlyBase:FBgn0024222]
exact_synonym: "Lipopolysaccharide activated kinase" [FlyBase:FBgn0024222]
exact_synonym: "Lipopolysaccharide-activated kinase" [UniProt:Q9VEZ5]
exact_synonym: "LPS-responsive kinase" [FlyBase:FBgn0024222]
exact_synonym: "LPS-responsive-kinase" [FlyBase:FBgn0024222]
exact_synonym: "LRK" [FlyBase:FBgn0024222]
xref_analog: UniProt:Q9VEZ5
relationship: sequence_of IMR:0100459 ! IKK beta

[Term]
id: IMR:0001813
name: NEMO_DROME
exact_synonym: "CG16910" [FlyBase:FBgn0041205]
exact_synonym: "dIKK" [FlyBase:FBgn0041205]
exact_synonym: "dIKK-gamma" [FlyBase:FBgn0041205]
exact_synonym: "DmIKKgamma" [UniProt:Q9GYV5, FlyBase:FBgn0041205]
exact_synonym: "Dmikkgamma" [FlyBase:FBgn0041205]
exact_synonym: "dmIKKgamma" [FlyBase:FBgn0041205]
exact_synonym: "IKK-gamma" [FlyBase:FBgn0041205]
exact_synonym: "IKKGAMMA" [UniProt:Q9GYV5]
exact_synonym: "IKKgamma" [FlyBase:FBgn0041205]
exact_synonym: "Inhibitor of nuclear factor kappa B kinase subunit gamma" [UniProt:Q9GYV5]
exact_synonym: "Kenny" [FlyBase:FBgn0041205]
exact_synonym: "kenny" [FlyBase:FBgn0041205]
exact_synonym: "key" [UniProt:Q9GYV5, FlyBase:FBgn0041205]
exact_synonym: "NEMO homolog" [UniProt:Q9GYV5]
exact_synonym: "NF-kappa-B essential modulator" [UniProt:Q9GYV5]
xref_analog: UniProt:Q9GYV5
relationship: sequence_of IMR:0100460 ! IKK gamma

[Term]
id: IMR:0001814
name: NFKB1_DROME
def: "Relish contains both a Rel homology domain and an IkappaB-like domain with six ankyrin repeats like p105 and p100. However, Relish may have branched off from other Rel proteins at a very early stage. The regulation of Relish is also unique among the NF-kappaB precursor proteins." [PubMed:11562344, PubMed:8816802]
exact_synonym: "CG11992" [FlyBase:FBgn0014018]
exact_synonym: "immune response deficient 4" [FlyBase:FBgn0014018]
exact_synonym: "ird" [FlyBase:FBgn0014018]
exact_synonym: "ird4" [FlyBase:FBgn0014018]
exact_synonym: "l(3)neo36" [FlyBase:FBgn0014018]
exact_synonym: "Nuclear factor NF-kappa-B p110 subunit" [UniProt:Q94527]
exact_synonym: "Nuclear factor NF-kappa-B p49 subunit" [UniProt:Q94527]
exact_synonym: "Nuclear factor NF-kappa-B p68 subunit" [UniProt:Q94527]
exact_synonym: "Rel" [UniProt:Q94527, FlyBase:FBgn0014018]
exact_synonym: "REL" [FlyBase:FBgn0014018]
exact_synonym: "rel" [FlyBase:FBgn0014018]
exact_synonym: "Rel-p110" [UniProt:Q94527]
exact_synonym: "Rel-p49" [UniProt:Q94527]
exact_synonym: "Rel-p68" [UniProt:Q94527]
exact_synonym: "relish" [FlyBase:FBgn0014018]
exact_synonym: "Relish" [FlyBase:FBgn0014018]
exact_synonym: "Relish protein" [UniProt:Q94527]
xref_analog: UniProt:Q94527
relationship: sequence_of IMR:0000382 ! NF-kappaB

[Term]
id: IMR:0001815
name: antimicrobial peptide
xref_analog: GO:0006952
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0001816
name: Q8SWW8_DROME
exact_synonym: "Defense repressor 1" [UniProt:Q8SWW8]
exact_synonym: "defense repressor 1" [FlyBase:FBgn0260866]
exact_synonym: "dnr1" [FlyBase:FBgn0260866, UniProt:Q8SWW8]
exact_synonym: "Dnr1" [UniProt:Q8SWW8]
exact_synonym: "LD18186p" [UniProt:Q8SWW8]
xref_analog: UniProt:Q8SWW8
relationship: sequence_of IMR:0000428 ! signal regulator

[Term]
id: IMR:0001817
name: DIP_DROME
exact_synonym: "CG12763" [FlyBase:FBgn0004240]
exact_synonym: "dip" [FlyBase:FBgn0004240]
exact_synonym: "Dip" [FlyBase:FBgn0004240]
exact_synonym: "Dipt" [FlyBase:FBgn0004240, UniProt:P24492]
exact_synonym: "DIPT" [FlyBase:FBgn0004240]
exact_synonym: "dipt" [FlyBase:FBgn0004240]
exact_synonym: "Diptericin" [FlyBase:FBgn0004240, UniProt:P24492]
exact_synonym: "diptericin" [FlyBase:FBgn0004240]
exact_synonym: "Dpt" [FlyBase:FBgn0004240, UniProt:P24492]
exact_synonym: "dpt" [FlyBase:FBgn0004240]
exact_synonym: "DPT" [FlyBase:FBgn0004240]
exact_synonym: "DptA" [FlyBase:FBgn0004240]
xref_analog: UniProt:P24492
relationship: sequence_of IMR:0001815 ! antimicrobial peptide

[Term]
id: IMR:0001818
name: DMYC_DROME
exact_synonym: "BcDNA:LP03851" [FlyBase:FBgn0010381]
exact_synonym: "CG10810" [FlyBase:FBgn0010381]
exact_synonym: "CRP" [UniProt:P41964]
exact_synonym: "Crp" [FlyBase:FBgn0010381]
exact_synonym: "Cysteine-rich peptide" [UniProt:P41964]
exact_synonym: "cysteine-rich peptide" [FlyBase:FBgn0010381]
exact_synonym: "Cysteine-rich-protein" [FlyBase:FBgn0010381]
exact_synonym: "DIM 19" [FlyBase:FBgn0010381]
exact_synonym: "DRO" [FlyBase:FBgn0010381]
exact_synonym: "drom" [FlyBase:FBgn0010381]
exact_synonym: "DROM" [FlyBase:FBgn0010381]
exact_synonym: "Drom" [FlyBase:FBgn0010381]
exact_synonym: "Drosomycin" [UniProt:P41964, FlyBase:FBgn0010381]
exact_synonym: "drosomycin" [FlyBase:FBgn0010381]
exact_synonym: "Drosophila Immune induced molecule 19" [FlyBase:FBgn0010381]
exact_synonym: "Drs" [UniProt:P41964, FlyBase:FBgn0010381]
exact_synonym: "drs" [FlyBase:FBgn0010381]
exact_synonym: "DRS" [FlyBase:FBgn0010381]
exact_synonym: "drsm" [FlyBase:FBgn0010381]
xref_analog: UniProt:P41964
relationship: sequence_of IMR:0001815 ! antimicrobial peptide

[Term]
id: IMR:0001819
name: Cecropin
is_a: IMR:0001815 ! antimicrobial peptide

[Term]
id: IMR:0001820
name: CECA_DROME
exact_synonym: "Cec" [FlyBase:FBgn0000276, FlyBase:FBgn0000277]
exact_synonym: "CEC" [FlyBase:FBgn0000276]
exact_synonym: "cec" [FlyBase:FBgn0000276, FlyBase:FBgn0000277]
exact_synonym: "cecA" [FlyBase:FBgn0000276, FlyBase:FBgn0000277]
exact_synonym: "CecA" [FlyBase:FBgn0000276, FlyBase:FBgn0000277]
exact_synonym: "CecA1" [FlyBase:FBgn0000276]
exact_synonym: "cecA1" [FlyBase:FBgn0000276]
exact_synonym: "CecA2" [UniProt:P14954, FlyBase:FBgn0000277]
exact_synonym: "cecA2" [FlyBase:FBgn0000277]
exact_synonym: "Cecropin" [FlyBase:FBgn0000276, FlyBase:FBgn0000277]
exact_synonym: "cecropin" [FlyBase:FBgn0000276, FlyBase:FBgn0000277]
exact_synonym: "cecropin A" [FlyBase:FBgn0000276, FlyBase:FBgn0000277]
exact_synonym: "Cecropin A" [FlyBase:FBgn0000276, FlyBase:FBgn0000277]
exact_synonym: "cecropin A1" [FlyBase:FBgn0000276]
exact_synonym: "Cecropin A1" [FlyBase:FBgn0000276]
exact_synonym: "cecropin A2" [FlyBase:FBgn0000277]
exact_synonym: "Cecropin A2" [FlyBase:FBgn0000277]
exact_synonym: "Cecropin-A1/A2" [UniProt:P14954]
exact_synonym: "CG1365" [FlyBase:FBgn0000276]
exact_synonym: "CG1367" [FlyBase:FBgn0000277]
xref_analog: UniProt:P14954
relationship: sequence_of IMR:0001819 ! Cecropin

[Term]
id: IMR:0001821
name: CECB_DROME
exact_synonym: "Cec" [FlyBase:FBgn0000278]
exact_synonym: "cec" [FlyBase:FBgn0000278]
exact_synonym: "CecB" [UniProt:P14956, FlyBase:FBgn0000278]
exact_synonym: "cecB" [FlyBase:FBgn0000278]
exact_synonym: "Cecropin" [FlyBase:FBgn0000278]
exact_synonym: "cecropin" [FlyBase:FBgn0000278]
exact_synonym: "cecropin B" [FlyBase:FBgn0000278]
exact_synonym: "Cecropin B" [FlyBase:FBgn0000278]
exact_synonym: "Cecropin-B" [UniProt:P14956]
exact_synonym: "CG1878" [FlyBase:FBgn0000278]
xref_analog: UniProt:P14956
relationship: sequence_of IMR:0001819 ! Cecropin

[Term]
id: IMR:0001822
name: CECC_DROME
exact_synonym: "BcDNA:RH33561" [FlyBase:FBgn0000279]
exact_synonym: "Cec" [FlyBase:FBgn0000279]
exact_synonym: "cec" [FlyBase:FBgn0000279]
exact_synonym: "Cec-C" [FlyBase:FBgn0000279]
exact_synonym: "CecC" [FlyBase:FBgn0000279, UniProt:O16829]
exact_synonym: "cecC" [FlyBase:FBgn0000279]
exact_synonym: "Cecropin" [FlyBase:FBgn0000279]
exact_synonym: "cecropin" [FlyBase:FBgn0000279]
exact_synonym: "cecropin C" [FlyBase:FBgn0000279]
exact_synonym: "Cecropin C" [FlyBase:FBgn0000279]
exact_synonym: "Cecropin-C" [UniProt:O16829]
exact_synonym: "CG1373" [FlyBase:FBgn0000279]
xref_analog: UniProt:O16829
relationship: sequence_of IMR:0001819 ! Cecropin

[Term]
id: IMR:0001823
name: Attacin
is_a: IMR:0001815 ! antimicrobial peptide

[Term]
id: IMR:0001824
name: ATTA_DROME
exact_synonym: "anon-WO0140519.5" [FlyBase:FBgn0012042]
exact_synonym: "att" [FlyBase:FBgn0012042]
exact_synonym: "ATT" [FlyBase:FBgn0012042]
exact_synonym: "Att" [FlyBase:FBgn0012042]
exact_synonym: "att A" [FlyBase:FBgn0012042]
exact_synonym: "Att A" [FlyBase:FBgn0012042]
exact_synonym: "AttA" [UniProt:P45884, FlyBase:FBgn0012042]
exact_synonym: "attA" [FlyBase:FBgn0012042]
exact_synonym: "attacin" [FlyBase:FBgn0012042]
exact_synonym: "Attacin" [FlyBase:FBgn0012042]
exact_synonym: "Attacin A" [FlyBase:FBgn0012042]
exact_synonym: "attacin A" [FlyBase:FBgn0012042]
exact_synonym: "Attacin-A" [UniProt:P45884, FlyBase:FBgn0012042]
exact_synonym: "Attackin" [FlyBase:FBgn0012042]
exact_synonym: "BcDNA:LP05763" [FlyBase:FBgn0012042]
exact_synonym: "CG10146" [FlyBase:FBgn0012042]
xref_analog: UniProt:P45884
relationship: sequence_of IMR:0001823 ! Attacin

[Term]
id: IMR:0001825
name: ATTB_DROME
exact_synonym: "att" [FlyBase:FBgn0041581]
exact_synonym: "Att" [FlyBase:FBgn0041581]
exact_synonym: "attacin" [FlyBase:FBgn0041581]
exact_synonym: "Attacin" [FlyBase:FBgn0041581]
exact_synonym: "Attacin B" [FlyBase:FBgn0041581]
exact_synonym: "attacin B" [FlyBase:FBgn0041581]
exact_synonym: "Attacin B1" [FlyBase:FBgn0041581]
exact_synonym: "Attacin-B" [UniProt:Q9V751, FlyBase:FBgn0041581]
exact_synonym: "Attackin" [FlyBase:FBgn0041581]
exact_synonym: "AttB" [UniProt:Q9V751, FlyBase:FBgn0041581]
exact_synonym: "AttB1" [UniProt:Q9V751, FlyBase:FBgn0041581]
exact_synonym: "AttB2" [FlyBase:FBgn0041581]
exact_synonym: "AttBn" [FlyBase:FBgn0041581]
exact_synonym: "CG18372" [FlyBase:FBgn0041581]
xref_analog: UniProt:Q9V751
relationship: sequence_of IMR:0001823 ! Attacin

[Term]
id: IMR:0001826
name: ATTC_DROME
exact_synonym: "att" [FlyBase:FBgn0041579]
exact_synonym: "Att" [FlyBase:FBgn0041579]
exact_synonym: "attacin" [FlyBase:FBgn0041579]
exact_synonym: "Attacin" [FlyBase:FBgn0041579]
exact_synonym: "Attacin C" [FlyBase:FBgn0041579]
exact_synonym: "attacin C" [FlyBase:FBgn0041579]
exact_synonym: "Attacin-C" [FlyBase:FBgn0041579, UniProt:Q95NH6]
exact_synonym: "Attackin" [FlyBase:FBgn0041579]
exact_synonym: "AttC" [FlyBase:FBgn0041579, UniProt:Q95NH6]
exact_synonym: "CG4740" [FlyBase:FBgn0041579]
exact_synonym: "DIM 16" [FlyBase:FBgn0041579]
exact_synonym: "DIM-16" [FlyBase:FBgn0041579, UniProt:Q95NH6]
exact_synonym: "Drosophila Immune induced molecule 16" [FlyBase:FBgn0041579]
exact_synonym: "Immune-induced peptide 16" [UniProt:Q95NH6]
exact_synonym: "MPAC" [FlyBase:FBgn0041579, UniProt:Q95NH6]
xref_analog: UniProt:Q95NH6
relationship: sequence_of IMR:0001823 ! Attacin

[Term]
id: IMR:0001827
name: DROS_DROME
exact_synonym: "BcDNA:RH31634" [FlyBase:FBgn0010388]
exact_synonym: "CG10816" [FlyBase:FBgn0010388]
exact_synonym: "DIM 11" [FlyBase:FBgn0010388]
exact_synonym: "DIM 15" [FlyBase:FBgn0010388]
exact_synonym: "DIM 9" [FlyBase:FBgn0010388]
exact_synonym: "DIM-15" [FlyBase:FBgn0010388]
exact_synonym: "Drc" [FlyBase:FBgn0010388]
exact_synonym: "drc" [FlyBase:FBgn0010388]
exact_synonym: "Dro" [UniProt:P36193, FlyBase:FBgn0010388]
exact_synonym: "dro" [FlyBase:FBgn0010388]
exact_synonym: "DROC" [FlyBase:FBgn0010388]
exact_synonym: "Dros" [FlyBase:FBgn0010388]
exact_synonym: "Drosocin" [UniProt:P36193, FlyBase:FBgn0010388]
exact_synonym: "drosocin" [FlyBase:FBgn0010388]
exact_synonym: "Drosophila Immune induced molecule 11" [FlyBase:FBgn0010388]
exact_synonym: "Drosophila Immune induced molecule 15" [FlyBase:FBgn0010388]
exact_synonym: "Drosophila Immune induced molecule 9" [FlyBase:FBgn0010388]
exact_synonym: "IM15" [FlyBase:FBgn0010388]
xref_analog: UniProt:P36193
relationship: sequence_of IMR:0001815 ! antimicrobial peptide

[Term]
id: IMR:0001828
name: DEFI_DROME
exact_synonym: "CG1385" [FlyBase:FBgn0010385]
exact_synonym: "Def" [FlyBase:FBgn0010385, UniProt:P36192]
exact_synonym: "def" [FlyBase:FBgn0010385]
exact_synonym: "Defensin" [FlyBase:FBgn0010385, UniProt:P36192]
exact_synonym: "defensin" [FlyBase:FBgn0010385]
xref_analog: UniProt:P36192
relationship: sequence_of IMR:0001815 ! antimicrobial peptide

[Term]
id: IMR:0001829
name: O57440_XENLA
exact_synonym: "Homeodomain protein twin" [UniProt:O57440]
exact_synonym: "sia2" [UniProt:O57440]
exact_synonym: "Xtwn" [UniProt:O57440]
xref_analog: UniProt:O57440
relationship: sequence_of IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0001830
name: SIAM_XENLA
exact_synonym: "Homeobox protein siamois" [UniProt:Q91848]
exact_synonym: "siamois" [UniProt:Q91848]
xref_analog: UniProt:Q91848
relationship: sequence_of IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0001831
name: BAMBI
def: "BAMBI has been identified as an inhibitor of BMP signaling during Xenopus embryonic development. BAMBI shows sequence similarity to TGF-beta receptors, but lacks the intracellular kinase domain. BAMBI homologues have been isolated in mouse, humans, and zebrafish." [PubMed:11784015]
exact_synonym: "BMP and activin membrane bound inhibitor" []
exact_synonym: "BMP and activin membrane-bound inhibitor" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0001832
name: BAMBI_HUMAN
exact_synonym: "BAMBI" [EntrezGene:25805, UniProt:Q13145, HGNC:30251, MIM:604444]
exact_synonym: "BMP and activin membrane-bound inhibitor homolog" [UniProt:Q13145]
exact_synonym: "BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)" [EntrezGene:25805, HGNC:30251]
exact_synonym: "BMP AND ACTIVIN MEMBRANE-BOUND INHIBITOR, XENOPUS, HOMOLOG OF" [MIM:604444]
exact_synonym: "NEUROMEDIN A" [MIM:604444]
exact_synonym: "NMA" [EntrezGene:25805, UniProt:Q13145, HGNC:30251, MIM:604444]
exact_synonym: "Non-metastatic gene A protein" [UniProt:Q13145]
exact_synonym: "Putative transmembrane protein NMA" [UniProt:Q13145]
xref_analog: UniProt:Q13145
relationship: sequence_of IMR:0001831 ! BAMBI

[Term]
id: IMR:0001833
name: BAMBI_MOUSE
exact_synonym: "Bambi" [MGI:1915260, UniProt:Q9D0L6]
exact_synonym: "BMP and activin membrane-bound inhibitor homolog" [UniProt:Q9D0L6]
exact_synonym: "BMP and activin membrane-bound inhibitor, homolog (Xenopus laevis)" [MGI:1915260]
exact_synonym: "Nma" [UniProt:Q9D0L6]
exact_synonym: "Putative transmembrane protein NMA" [UniProt:Q9D0L6]
xref_analog: UniProt:Q9D0L6
relationship: sequence_of IMR:0001831 ! BAMBI

[Term]
id: IMR:0001834
name: BAMBI_RAT
exact_synonym: "Bambi" [RGD:621831, UniProt:Q91XN4]
exact_synonym: "BMP and activin membrane-bound inhibitor homolog" [UniProt:Q91XN4]
exact_synonym: "BMP and activin membrane-bound inhibitor, homolog (Xenopus laevis)" [RGD:621831]
exact_synonym: "Kinase-deficient TGFbeta superfamily receptor subunit" [UniProt:Q91XN4]
xref_analog: UniProt:Q91XN4
relationship: sequence_of IMR:0001831 ! BAMBI

[Term]
id: IMR:0001835
name: Q9PU19_XENLA
exact_synonym: "bambi" [UniProt:Q9PU19]
exact_synonym: "BMP and activin membrane-bound inhibitor homolog" [UniProt:Q9PU19]
xref_analog: UniProt:Q9PU19
relationship: sequence_of IMR:0001831 ! BAMBI

[Term]
id: IMR:0001836
name: FRS2
def: "Two members of the FRS2 family have been identified in mammals. Both FRS2alpha  and FRS2beta  contain a membrane-anchoring N-myristylation signal, a PTB domain, and a C-terminal region which contains tyrosine residues which, when phosphorylated, form the binding sites for the SH2 domain of Grb2 and the N-SH2 domain of Shp2. Now Xenopus homolog of FRS2 (xFRS2) was identified and characterized." [PubMed:10629055, PubMed:11463744]
exact_synonym: "FGF receptor substrate 2" []
exact_synonym: "SNT" []
exact_synonym: "suc-associated neurotrophic factor target" []
is_a: IMR:0000345 ! docking protein

[Term]
id: IMR:0001837
name: FRS2alpha
is_a: IMR:0001836 ! FRS2

[Term]
id: IMR:0001838
name: FRS2beta
is_a: IMR:0001836 ! FRS2

[Term]
id: IMR:0001839
name: FRS2_HUMAN
exact_synonym: "FGFR substrate 2" [UniProt:Q8WU20, MIM:607743]
exact_synonym: "FGFR-signaling adaptor SNT" [UniProt:Q8WU20]
exact_synonym: "Fibroblast growth factor receptor substrate 2" [UniProt:Q8WU20, MIM:607743]
exact_synonym: "fibroblast growth factor receptor substrate 2" [EntrezGene:10818, HGNC:16971]
exact_synonym: "FRS2" [UniProt:Q8WU20, MIM:607743, EntrezGene:10818, HGNC:16971]
exact_synonym: "FRS2-ALPHA" [MIM:607743]
exact_synonym: "FRS2A" [MIM:607743, EntrezGene:10818, HGNC:16971]
exact_synonym: "FRS2alpha" [EntrezGene:10818, HGNC:16971]
exact_synonym: "SNT" [MIM:607743, EntrezGene:10818]
exact_synonym: "SNT-1" [UniProt:Q8WU20, EntrezGene:10818, HGNC:16971]
exact_synonym: "SNT1" [MIM:607743, EntrezGene:10818, HGNC:16971]
exact_synonym: "Suc1-associated neurotrophic factor target 1" [UniProt:Q8WU20, MIM:607743]
xref_analog: UniProt:Q8WU20
relationship: sequence_of IMR:0001837 ! FRS2alpha

[Term]
id: IMR:0001840
name: FRS2_MOUSE
exact_synonym: "FGFR substrate 2" [UniProt:Q8C180]
exact_synonym: "FGFR-signaling adaptor SNT" [UniProt:Q8C180]
exact_synonym: "Fibroblast growth factor receptor substrate 2" [UniProt:Q8C180]
exact_synonym: "fibroblast growth factor receptor substrate 2" [MGI:1100860]
exact_synonym: "Frs2" [MGI:1100860, UniProt:Q8C180]
exact_synonym: "FRS2-alpha" [UniProt:Q8C180]
exact_synonym: "Frs2a" [UniProt:Q8C180]
exact_synonym: "Frs2alpha" [MGI:1100860]
exact_synonym: "SNT-1" [UniProt:Q8C180]
exact_synonym: "SNT1" [MGI:1100860]
exact_synonym: "Suc1-associated neurotrophic factor target 1" [UniProt:Q8C180]
xref_analog: UniProt:Q8C180
relationship: sequence_of IMR:0001837 ! FRS2alpha

[Term]
id: IMR:0001841
name: FRS3_HUMAN
exact_synonym: "FGFR substrate 3" [UniProt:O43559, MIM:607744]
exact_synonym: "FGFR-signaling adaptor SNT2" [UniProt:O43559]
exact_synonym: "Fibroblast growth factor receptor substrate 3" [UniProt:O43559, MIM:607744]
exact_synonym: "fibroblast growth factor receptor substrate 3" [EntrezGene:10817, HGNC:16970]
exact_synonym: "FRS2-BETA" [MIM:607744]
exact_synonym: "FRS2B" [EntrezGene:10817, MIM:607744, HGNC:16970]
exact_synonym: "FRS2beta" [EntrezGene:10817, HGNC:16970]
exact_synonym: "FRS3" [UniProt:O43559, EntrezGene:10817, MIM:607744, HGNC:16970]
exact_synonym: "MGC17167" [EntrezGene:10817]
exact_synonym: "SNT-2" [UniProt:O43559, EntrezGene:10817, HGNC:16970]
exact_synonym: "SNT2" [EntrezGene:10817, MIM:607744]
exact_synonym: "Suc1-associated neurotrophic factor target 2" [UniProt:O43559, MIM:607744]
xref_analog: UniProt:O43559
relationship: sequence_of IMR:0001838 ! FRS2beta

[Term]
id: IMR:0001842
name: FRS3_MOUSE
exact_synonym: "FGFR substrate 3" [UniProt:Q91WJ0]
exact_synonym: "Fibroblast growth factor receptor substrate 3" [UniProt:Q91WJ0]
exact_synonym: "fibroblast growth factor receptor substrate 3" [MGI:2135965]
exact_synonym: "FRS2-beta" [UniProt:Q91WJ0]
exact_synonym: "Frs2b" [UniProt:Q91WJ0]
exact_synonym: "Frs2beta" [MGI:2135965]
exact_synonym: "Frs3" [UniProt:Q91WJ0, MGI:2135965]
exact_synonym: "SNT2" [MGI:2135965]
xref_analog: UniProt:Q91WJ0
relationship: sequence_of IMR:0001838 ! FRS2beta

[Term]
id: IMR:0001843
name: FRS3_RAT
exact_synonym: "FGFR substrate 3" [UniProt:Q52RG8]
exact_synonym: "FGFR-signaling adaptor SNT2" [UniProt:Q52RG8]
exact_synonym: "Fibroblast growth factor receptor substrate 3" [UniProt:Q52RG8]
exact_synonym: "fibroblast growth factor receptor substrate 3" [RGD:1310226]
exact_synonym: "Frs3" [RGD:1310226, UniProt:Q52RG8]
exact_synonym: "SNT-2" [UniProt:Q52RG8]
exact_synonym: "Snt2" [UniProt:Q52RG8]
exact_synonym: "Suc1-associated neurotrophic factor target 2" [UniProt:Q52RG8]
xref_analog: UniProt:Q52RG8
relationship: sequence_of IMR:0001838 ! FRS2beta

[Term]
id: IMR:0001844
name: S6K
exact_synonym: "ribosomal S6 protein kinase" []
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0001845
name: p70S6K
exact_synonym: "70 kDa ribosomal S6 kinase" []
is_a: IMR:0001844 ! S6K

[Term]
id: IMR:0001846
name: RSK1
exact_synonym: "90 kDa ribosomal S6 kinase1" []
exact_synonym: "p90RSK1" []
is_a: IMR:0000248 ! RSK

[Term]
id: IMR:0001847
name: RSK2
exact_synonym: "90 kDa ribosomal S6 kinase2" []
exact_synonym: "p90RSK2" []
is_a: IMR:0000248 ! RSK

[Term]
id: IMR:0001848
name: RSK3
exact_synonym: "90 kDa ribosomal S6 kinase3" []
exact_synonym: "p90RSK3" []
is_a: IMR:0000248 ! RSK

[Term]
id: IMR:0001849
name: Q63ZT4_XENLA
exact_synonym: "beta-catenin" [UniProt:Q63ZT4]
exact_synonym: "Beta-catenin protein" [UniProt:Q63ZT4]
exact_synonym: "ctnnb1" [UniProt:Q63ZT4]
xref_analog: UniProt:Q63ZT4
relationship: sequence_of IMR:0000177 ! beta-catenin

[Term]
id: IMR:0001850
name: TLE4_XENLA
exact_synonym: "Enhancer of split groucho-like protein 2" [UniProt:O42478]
exact_synonym: "ESG2" [UniProt:O42478]
exact_synonym: "esg2" [UniProt:O42478]
exact_synonym: "Grg-4" [UniProt:O42478]
exact_synonym: "Groucho-related protein 4" [UniProt:O42478]
exact_synonym: "tle4" [UniProt:O42478]
exact_synonym: "Transducin-like enhancer protein 4" [UniProt:O42478]
exact_synonym: "xESG2" [UniProt:O42478]
exact_synonym: "XGrg-4" [UniProt:O42478]
xref_analog: UniProt:O42478
relationship: sequence_of IMR:0100748 ! Groucho/TLE family

[Term]
id: IMR:0001851
name: T7L1A_XENLA
exact_synonym: "HMG box transcription factor 3-A" [UniProt:P70062]
exact_synonym: "TCF-3-A" [UniProt:P70062]
exact_synonym: "tcf3" [UniProt:P70062]
exact_synonym: "tcf3a" [UniProt:P70062]
exact_synonym: "tcf7l1-a" [UniProt:P70062]
exact_synonym: "Transcription factor 7-like 1-A" [UniProt:P70062]
exact_synonym: "xTcf-3" [UniProt:P70062]
xref_analog: UniProt:P70062
relationship: sequence_of IMR:0000418 ! TCF/LEF-1 family

[Term]
id: IMR:0001852
name: fringe
def: "Fringe is a glycosyltransferase that acts directly on Notch to change Notch signaling. Drosophila fringe and its mammalian homologues, Radical, Lunatic and Manic fringe, play key roles in development." [PubMed:12417415]
is_a: IMR:0001379 ! glycosyltransferase

[Term]
id: IMR:0001853
name: FNG_DROME
exact_synonym: "CG10580" [FlyBase:FBgn0011591]
exact_synonym: "D-fng" [FlyBase:FBgn0011591]
exact_synonym: "D-Fng" [FlyBase:FBgn0011591]
exact_synonym: "Dfng" [FlyBase:FBgn0011591]
exact_synonym: "EC 2.4.1.222" [UniProt:Q24342]
exact_synonym: "fg" [FlyBase:FBgn0011591]
exact_synonym: "fng" [UniProt:Q24342, FlyBase:FBgn0011591]
exact_synonym: "frg" [FlyBase:FBgn0011591]
exact_synonym: "Frg" [FlyBase:FBgn0011591]
exact_synonym: "fringe" [FlyBase:FBgn0011591]
exact_synonym: "Fringe glycosyltransferase" [UniProt:Q24342]
exact_synonym: "l(3)rG554" [FlyBase:FBgn0011591]
exact_synonym: "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" [UniProt:Q24342]
xref_analog: UniProt:Q24342
relationship: sequence_of IMR:0001852 ! fringe

[Term]
id: IMR:0001854
name: Lunatic fringe
exact_synonym: "Lfng" []
is_a: IMR:0001852 ! fringe

[Term]
id: IMR:0001855
name: LFNG_HUMAN
exact_synonym: "Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe" [UniProt:Q8NES3]
exact_synonym: "EC 2.4.1.222" [UniProt:Q8NES3]
exact_synonym: "FRINGE, DROSOPHILA, HOMOLOG OF, LUNATIC" [MIM:602576]
exact_synonym: "LFNG" [UniProt:Q8NES3, EntrezGene:3955, MIM:602576, HGNC:6560]
exact_synonym: "LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" [EntrezGene:3955, HGNC:6560]
exact_synonym: "LUNATIC FRINGE" [MIM:602576]
exact_synonym: "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" [UniProt:Q8NES3]
exact_synonym: "SCDO3" [EntrezGene:3955, HGNC:6560]
xref_analog: UniProt:Q8NES3
relationship: sequence_of IMR:0001854 ! Lunatic fringe

[Term]
id: IMR:0001856
name: LFNG_MOUSE
exact_synonym: "Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe" [UniProt:O09010]
exact_synonym: "EC 2.4.1.222" [UniProt:O09010]
exact_synonym: "Lfng" [MGI:1095413, UniProt:O09010]
exact_synonym: "LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" [MGI:1095413]
exact_synonym: "lunatic fringe" [MGI:1095413]
exact_synonym: "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" [UniProt:O09010]
xref_analog: UniProt:O09010
relationship: sequence_of IMR:0001854 ! Lunatic fringe

[Term]
id: IMR:0001857
name: LFNG_RAT
exact_synonym: "Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe" [UniProt:Q924T4]
exact_synonym: "EC 2.4.1.222" [UniProt:Q924T4]
exact_synonym: "Lfng" [UniProt:Q924T4, RGD:620587]
exact_synonym: "LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" [RGD:620587]
exact_synonym: "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" [UniProt:Q924T4]
xref_analog: UniProt:Q924T4
relationship: sequence_of IMR:0001854 ! Lunatic fringe

[Term]
id: IMR:0001858
name: Manic fringe
exact_synonym: "Mfng" []
is_a: IMR:0001852 ! fringe

[Term]
id: IMR:0001859
name: MFNG_HUMAN
exact_synonym: "Beta-1,3-N-acetylglucosaminyltransferase manic fringe" [UniProt:O00587]
exact_synonym: "EC 2.4.1.222" [UniProt:O00587]
exact_synonym: "FRINGE, DROSOPHILA, HOMOLOG OF, MANIC" [MIM:602577]
exact_synonym: "MANIC FRINGE" [MIM:602577]
exact_synonym: "MFNG" [EntrezGene:4242, UniProt:O00587, MIM:602577, HGNC:7038]
exact_synonym: "MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" [EntrezGene:4242, HGNC:7038]
exact_synonym: "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" [UniProt:O00587]
xref_analog: UniProt:O00587
relationship: sequence_of IMR:0001858 ! Manic fringe

[Term]
id: IMR:0001860
name: MFNG_MOUSE
exact_synonym: "Beta-1,3-N-acetylglucosaminyltransferase manic fringe" [UniProt:O09008]
exact_synonym: "EC 2.4.1.222" [UniProt:O09008]
exact_synonym: "manic fringe" [MGI:1095404]
exact_synonym: "Mfng" [UniProt:O09008, MGI:1095404]
exact_synonym: "MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" [MGI:1095404]
exact_synonym: "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" [UniProt:O09008]
xref_analog: UniProt:O09008
relationship: sequence_of IMR:0001858 ! Manic fringe

[Term]
id: IMR:0001861
name: Radical fringe
exact_synonym: "Rfng" []
is_a: IMR:0001852 ! fringe

[Term]
id: IMR:0001862
name: RFNG_HUMAN
exact_synonym: "Beta-1,3-N-acetylglucosaminyltransferase radical fringe" [UniProt:Q9Y644]
exact_synonym: "EC 2.4.1.222" [UniProt:Q9Y644]
exact_synonym: "FRINGE, DROSOPHILA, HOMOLOG OF, RADICAL" [MIM:602578]
exact_synonym: "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" [UniProt:Q9Y644]
exact_synonym: "RADICAL FRINGE" [MIM:602578]
exact_synonym: "RFNG" [UniProt:Q9Y644, MIM:602578, EntrezGene:5986, HGNC:9974]
exact_synonym: "RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" [EntrezGene:5986, HGNC:9974]
xref_analog: UniProt:Q9Y644
relationship: sequence_of IMR:0001861 ! Radical fringe

[Term]
id: IMR:0001863
name: RFNG_MOUSE
exact_synonym: "Beta-1,3-N-acetylglucosaminyltransferase radical fringe" [UniProt:O09009]
exact_synonym: "EC 2.4.1.222" [UniProt:O09009]
exact_synonym: "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" [UniProt:O09009]
exact_synonym: "radical fringe" [MGI:894275]
exact_synonym: "Rfng" [UniProt:O09009, MGI:894275]
exact_synonym: "RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" [MGI:894275]
xref_analog: UniProt:O09009
relationship: sequence_of IMR:0001861 ! Radical fringe

[Term]
id: IMR:0001864
name: RFNG_RAT
exact_synonym: "Beta-1,3-N-acetylglucosaminyltransferase radical fringe" [UniProt:Q9R1U9]
exact_synonym: "EC 2.4.1.222" [UniProt:Q9R1U9]
exact_synonym: "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" [UniProt:Q9R1U9]
exact_synonym: "Rfng" [RGD:621322, UniProt:Q9R1U9]
exact_synonym: "RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" [RGD:621322]
xref_analog: UniProt:Q9R1U9
relationship: sequence_of IMR:0001861 ! Radical fringe

[Term]
id: IMR:0001865
name: ADAM family
exact_synonym: "a disintegrin and metalloproteinase" []
is_a: IMR:0000304 ! protease

[Term]
id: IMR:0001866
name: Q94902_DROME
exact_synonym: "34Da" [FlyBase:FBgn0259984]
exact_synonym: "BG:DS07660.3" [FlyBase:FBgn0259984]
exact_synonym: "br38" [FlyBase:FBgn0259984]
exact_synonym: "CG7147" [FlyBase:FBgn0259984]
exact_synonym: "CT22079" [FlyBase:FBgn0259984]
exact_synonym: "kuz" [FlyBase:FBgn0259984, UniProt:Q94902]
exact_synonym: "Kuzbanian" [UniProt:Q94902]
exact_synonym: "kuzbanian" [FlyBase:FBgn0259984]
exact_synonym: "l(2)03782" [FlyBase:FBgn0259984]
exact_synonym: "l(2)34Da" [FlyBase:FBgn0259984]
exact_synonym: "l(2)br38" [FlyBase:FBgn0259984]
exact_synonym: "l(2)c00136" [FlyBase:FBgn0259984]
exact_synonym: "l(2)k01403" [FlyBase:FBgn0259984]
exact_synonym: "l34Da" [FlyBase:FBgn0259984]
exact_synonym: "lethal (2) c00136" [FlyBase:FBgn0259984]
xref_analog: UniProt:Q94902
relationship: sequence_of IMR:0001865 ! ADAM family

[Term]
id: IMR:0001867
name: TACE
exact_synonym: "a disintegrin and metalloproteinase 17" []
exact_synonym: "ADAM17" []
exact_synonym: "TNF-alpha converting enzyme" []
is_a: IMR:0001865 ! ADAM family

[Term]
id: IMR:0001868
name: ADA17_HUMAN
exact_synonym: "A DISINTEGRIN AND METALLOPROTEINASE DOMAIN 17" [MIM:603639]
exact_synonym: "ADAM 17" [UniProt:P78536]
exact_synonym: "ADAM metallopeptidase domain 17" [EntrezGene:6868, HGNC:195]
exact_synonym: "ADAM17" [UniProt:P78536, EntrezGene:6868, MIM:603639, HGNC:195]
exact_synonym: "ADAM18" [EntrezGene:6868]
exact_synonym: "CD156b" [UniProt:P78536]
exact_synonym: "CD156B" [EntrezGene:6868, HGNC:195]
exact_synonym: "CSVP" [UniProt:P78536, EntrezGene:6868]
exact_synonym: "cSVP" [HGNC:195]
exact_synonym: "Disintegrin and metalloproteinase domain-containing protein 17" [UniProt:P78536]
exact_synonym: "EC 3.4.24.86" [UniProt:P78536]
exact_synonym: "MGC71942" [EntrezGene:6868]
exact_synonym: "Snake venom-like protease" [UniProt:P78536]
exact_synonym: "TACE" [UniProt:P78536, EntrezGene:6868, MIM:603639]
exact_synonym: "TNF-alpha convertase" [UniProt:P78536]
exact_synonym: "TNF-alpha-converting enzyme" [UniProt:P78536]
exact_synonym: "TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME" [MIM:603639]
xref_analog: UniProt:P78536
relationship: sequence_of IMR:0001867 ! TACE

[Term]
id: IMR:0001869
name: ADA17_MOUSE
exact_synonym: "a disintegrin and metallopeptidase domain 17" [MGI:1096335]
exact_synonym: "ADAM 17" [UniProt:Q9Z0F8]
exact_synonym: "Adam17" [MGI:1096335, UniProt:Q9Z0F8]
exact_synonym: "CD156b" [MGI:1096335, UniProt:Q9Z0F8]
exact_synonym: "Disintegrin and metalloproteinase domain-containing protein 17" [UniProt:Q9Z0F8]
exact_synonym: "EC 3.4.24.86" [UniProt:Q9Z0F8]
exact_synonym: "Tace" [MGI:1096335, UniProt:Q9Z0F8]
exact_synonym: "TNF-alpha convertase" [UniProt:Q9Z0F8]
exact_synonym: "TNF-alpha-converting enzyme" [UniProt:Q9Z0F8]
xref_analog: UniProt:Q9Z0F8
relationship: sequence_of IMR:0001867 ! TACE

[Term]
id: IMR:0001870
name: ADA17_RAT
exact_synonym: "ADAM 17" [UniProt:Q9Z1K9]
exact_synonym: "ADAM metallopeptidase domain 17" [RGD:620404]
exact_synonym: "Adam17" [UniProt:Q9Z1K9, RGD:620404]
exact_synonym: "CD156b" [UniProt:Q9Z1K9]
exact_synonym: "Disintegrin and metalloproteinase domain-containing protein 17" [UniProt:Q9Z1K9]
exact_synonym: "EC 3.4.24.86" [UniProt:Q9Z1K9]
exact_synonym: "Tace" [UniProt:Q9Z1K9]
exact_synonym: "TNF-alpha convertase" [UniProt:Q9Z1K9]
exact_synonym: "TNF-alpha-converting enzyme" [UniProt:Q9Z1K9]
xref_analog: UniProt:Q9Z1K9
relationship: sequence_of IMR:0001867 ! TACE

[Term]
id: IMR:0001871
name: ADAM10
exact_synonym: "a disintegrin and metalloproteinase 10" []
is_a: IMR:0001865 ! ADAM family

[Term]
id: IMR:0001872
name: ADA10_HUMAN
exact_synonym: "A DISINTEGRIN AND METALLOPROTEINASE DOMAIN 10" [MIM:602192]
exact_synonym: "AD10" [MIM:602192, EntrezGene:102]
exact_synonym: "ADAM 10" [UniProt:O14672]
exact_synonym: "ADAM metallopeptidase domain 10" [HGNC:188, EntrezGene:102]
exact_synonym: "ADAM10" [MIM:602192, UniProt:O14672, HGNC:188, EntrezGene:102]
exact_synonym: "CD156c" [UniProt:O14672, HGNC:188, EntrezGene:102]
exact_synonym: "CDw156" [UniProt:O14672]
exact_synonym: "Disintegrin and metalloproteinase domain-containing protein 10" [UniProt:O14672]
exact_synonym: "EC 3.4.24.81" [UniProt:O14672]
exact_synonym: "HsT18717" [HGNC:188, EntrezGene:102]
exact_synonym: "KUZ" [MIM:602192, UniProt:O14672]
exact_synonym: "kuz" [HGNC:188, EntrezGene:102]
exact_synonym: "Kuzbanian protein homolog" [UniProt:O14672]
exact_synonym: "KUZBANIAN, DROSOPHILA, HOMOLOG OF" [MIM:602192]
exact_synonym: "MADM" [UniProt:O14672, HGNC:188, EntrezGene:102]
exact_synonym: "Mammalian disintegrin-metalloprotease" [UniProt:O14672]
xref_analog: UniProt:O14672
relationship: sequence_of IMR:0001871 ! ADAM10

[Term]
id: IMR:0001873
name: ADA10_MOUSE
exact_synonym: "a disintegrin and metallopeptidase domain 10" [MGI:109548]
exact_synonym: "ADAM 10" [UniProt:O35598]
exact_synonym: "Adam10" [UniProt:O35598, MGI:109548]
exact_synonym: "CD156c" [UniProt:O35598]
exact_synonym: "Disintegrin and metalloproteinase domain-containing protein 10" [UniProt:O35598]
exact_synonym: "EC 3.4.24.81" [UniProt:O35598]
exact_synonym: "Kuz" [UniProt:O35598]
exact_synonym: "kuz" [MGI:109548]
exact_synonym: "kuzbanian" [MGI:109548]
exact_synonym: "Kuzbanian protein homolog" [UniProt:O35598]
exact_synonym: "Madm" [UniProt:O35598]
exact_synonym: "Mammalian disintegrin-metalloprotease" [UniProt:O35598]
xref_analog: UniProt:O35598
relationship: sequence_of IMR:0001871 ! ADAM10

[Term]
id: IMR:0001874
name: ADA10_RAT
exact_synonym: "ADAM 10" [UniProt:Q10743]
exact_synonym: "ADAM metallopeptidase domain 10" [RGD:2032]
exact_synonym: "Adam10" [RGD:2032, UniProt:Q10743]
exact_synonym: "CD156c" [UniProt:Q10743]
exact_synonym: "Disintegrin and metalloproteinase domain-containing protein 10" [UniProt:Q10743]
exact_synonym: "EC 3.4.24.81" [UniProt:Q10743]
exact_synonym: "Kuzbanian protein homolog" [UniProt:Q10743]
exact_synonym: "Madm" [UniProt:Q10743]
exact_synonym: "Mammalian disintegrin-metalloprotease" [UniProt:Q10743]
xref_analog: UniProt:Q10743
relationship: sequence_of IMR:0001871 ! ADAM10

[Term]
id: IMR:0001875
name: O46354_CAEEL
exact_synonym: "ADAM 10" [UniProt:O46354]
exact_synonym: "Protein DY3.7, confirmed by transcript evidence" [UniProt:O46354]
exact_synonym: "sup-17" [UniProt:O46354]
xref_analog: UniProt:O46354
relationship: sequence_of IMR:0001865 ! ADAM family

[Term]
id: IMR:0001876
name: nicastrin
is_a: IMR:0000429 ! enzyme regulator
relationship: part_of IMR:0001882 ! gamma-secretase complex

[Term]
id: IMR:0001877
name: NICA_CAEEL
exact_synonym: "Anterior-pharynx-defective protein 2" [UniProt:Q23316]
exact_synonym: "aph-2" [UniProt:Q23316]
exact_synonym: "Nicastrin" [UniProt:Q23316]
xref_analog: UniProt:Q23316
relationship: sequence_of IMR:0001876 ! nicastrin

[Term]
id: IMR:0001878
name: NICA_DROME
exact_synonym: "agoraphobic" [FlyBase:FBgn0039234]
exact_synonym: "agro" [FlyBase:FBgn0039234]
exact_synonym: "CG7012" [FlyBase:FBgn0039234]
exact_synonym: "dNicastrin" [FlyBase:FBgn0039234]
exact_synonym: "NCSTN" [UniProt:Q9VC27]
exact_synonym: "nct" [UniProt:Q9VC27, FlyBase:FBgn0039234]
exact_synonym: "Nct" [FlyBase:FBgn0039234]
exact_synonym: "Nic" [FlyBase:FBgn0039234]
exact_synonym: "Nicastrin" [UniProt:Q9VC27, FlyBase:FBgn0039234]
exact_synonym: "nicastrin" [FlyBase:FBgn0039234]
exact_synonym: "S5A" [FlyBase:FBgn0039234]
xref_analog: UniProt:Q9VC27
relationship: sequence_of IMR:0001876 ! nicastrin

[Term]
id: IMR:0001879
name: NICA_HUMAN
exact_synonym: "ANTERIOR PHARYNX DEFECTIVE 2, C. ELEGANS, HOMOLOG OF" [MIM:605254]
exact_synonym: "APH2" [MIM:605254, EntrezGene:23385, HGNC:17091]
exact_synonym: "KIAA0253" [EntrezGene:23385, UniProt:Q92542, HGNC:17091]
exact_synonym: "NCSTN" [MIM:605254, EntrezGene:23385, UniProt:Q92542, HGNC:17091]
exact_synonym: "Nicastrin" [MIM:605254, UniProt:Q92542]
exact_synonym: "nicastrin" [EntrezGene:23385, HGNC:17091]
xref_analog: UniProt:Q92542
relationship: sequence_of IMR:0001876 ! nicastrin

[Term]
id: IMR:0001880
name: NICA_MOUSE
exact_synonym: "D1Dau13e" [MGI:1891700]
exact_synonym: "Ncstn" [MGI:1891700, UniProt:P57716]
exact_synonym: "Nct" [MGI:1891700]
exact_synonym: "Nicastrin" [UniProt:P57716]
exact_synonym: "nicastrin" [MGI:1891700]
xref_analog: UniProt:P57716
relationship: sequence_of IMR:0001876 ! nicastrin

[Term]
id: IMR:0001881
name: NICA_RAT
exact_synonym: "Ncstn" [RGD:631418, UniProt:Q8CGU6]
exact_synonym: "Nicastrin" [UniProt:Q8CGU6]
exact_synonym: "nicastrin" [RGD:631418]
xref_analog: UniProt:Q8CGU6
relationship: sequence_of IMR:0001876 ! nicastrin

[Term]
id: IMR:0001882
name: gamma-secretase complex
is_a: IMR:0000304 ! protease

[Term]
id: IMR:0001883
name: Aph-1
is_a: IMR:0000429 ! enzyme regulator
relationship: part_of IMR:0001882 ! gamma-secretase complex

[Term]
id: IMR:0001884
name: APH1_DROME
exact_synonym: "anterior pharynx defective 1" [FlyBase:FBgn0031458]
exact_synonym: "aph-1" [FlyBase:FBgn0031458, UniProt:Q9VQG2]
exact_synonym: "Aph-1" [FlyBase:FBgn0031458]
exact_synonym: "CG2855" [FlyBase:FBgn0031458]
exact_synonym: "Dm APH-1" [FlyBase:FBgn0031458]
exact_synonym: "Gamma-secretase subunit Aph-1" [UniProt:Q9VQG2]
exact_synonym: "l(2)23AB6" [FlyBase:FBgn0031458]
exact_synonym: "l(2)23Ag" [FlyBase:FBgn0031458]
exact_synonym: "Pen-1" [FlyBase:FBgn0031458]
exact_synonym: "pen-1" [FlyBase:FBgn0031458]
exact_synonym: "presenilin enhancer-1" [FlyBase:FBgn0031458]
exact_synonym: "presenilin stabilization factor" [FlyBase:FBgn0031458]
exact_synonym: "Presenilin-stabilization factor" [UniProt:Q9VQG2]
exact_synonym: "PSF" [UniProt:Q9VQG2]
xref_analog: UniProt:Q9VQG2
relationship: sequence_of IMR:0001883 ! Aph-1

[Term]
id: IMR:0001885
name: Aph-1a
exact_synonym: "Aph-1alpha" []
is_a: IMR:0001883 ! Aph-1

[Term]
id: IMR:0001886
name: Aph-1b
exact_synonym: "Aph-1beta" []
is_a: IMR:0001883 ! Aph-1

[Term]
id: IMR:0001887
name: APH1A_HUMAN
exact_synonym: "6530402N02Rik" [EntrezGene:51107]
exact_synonym: "anterior pharynx defective 1 homolog A (C. elegans)" [EntrezGene:51107, HGNC:29509]
exact_synonym: "ANTERIOR PHARYNX DEFECTIVE 1, C. ELEGANS, HOMOLOG OF, A" [MIM:607629]
exact_synonym: "APH-1" [EntrezGene:51107]
exact_synonym: "APH-1a" [UniProt:Q96BI3]
exact_synonym: "APH-1A" [EntrezGene:51107, HGNC:29509]
exact_synonym: "Aph-1alpha" [UniProt:Q96BI3]
exact_synonym: "APH1A" [MIM:607629, UniProt:Q96BI3, EntrezGene:51107, HGNC:29509]
exact_synonym: "CGI-78" [EntrezGene:51107, HGNC:29509]
exact_synonym: "Gamma-secretase subunit APH-1A" [UniProt:Q96BI3]
exact_synonym: "Presenilin-stabilization factor" [UniProt:Q96BI3]
exact_synonym: "PSF" [UniProt:Q96BI3]
xref_analog: UniProt:Q96BI3
relationship: sequence_of IMR:0001885 ! Aph-1a

[Term]
id: IMR:0001888
name: APH1A_MOUSE
exact_synonym: "anterior pharynx defective 1a homolog (C. elegans)" [MGI:2385110]
exact_synonym: "APH-1a" [UniProt:Q8BVF7]
exact_synonym: "Aph-1alpha" [UniProt:Q8BVF7]
exact_synonym: "Aph1a" [MGI:2385110, UniProt:Q8BVF7]
exact_synonym: "Gamma-secretase subunit APH-1A" [UniProt:Q8BVF7]
xref_analog: UniProt:Q8BVF7
relationship: sequence_of IMR:0001885 ! Aph-1a

[Term]
id: IMR:0001889
name: APH1B_HUMAN
exact_synonym: "anterior pharynx defective 1 homolog B (C. elegans)" [HGNC:24080, EntrezGene:83464]
exact_synonym: "ANTERIOR PHARYNX DEFECTIVE 1, C. ELEGANS, HOMOLOG OF, B" [MIM:607630]
exact_synonym: "APH-1b" [UniProt:Q8WW43]
exact_synonym: "APH-1B" [HGNC:24080, EntrezGene:83464]
exact_synonym: "Aph-1beta" [UniProt:Q8WW43]
exact_synonym: "APH1B" [MIM:607630, HGNC:24080, EntrezGene:83464, UniProt:Q8WW43]
exact_synonym: "DKFZp564D0372" [HGNC:24080, EntrezGene:83464]
exact_synonym: "FLJ33115" [EntrezGene:83464]
exact_synonym: "Gamma-secretase subunit APH-1B" [UniProt:Q8WW43]
exact_synonym: "Presenilin-stabilization factor-like" [UniProt:Q8WW43]
exact_synonym: "PRO1328" [EntrezGene:83464]
exact_synonym: "PSFL" [HGNC:24080, EntrezGene:83464, UniProt:Q8WW43]
exact_synonym: "TAAV688" [EntrezGene:83464]
xref_analog: UniProt:Q8WW43
relationship: sequence_of IMR:0001886 ! Aph-1b

[Term]
id: IMR:0001890
name: APH1B_MOUSE
exact_synonym: "anterior pharynx defective 1b homolog (C. elegans)" [MGI:3522097]
exact_synonym: "APH-1b" [UniProt:Q8C7N7]
exact_synonym: "Aph-1beta" [UniProt:Q8C7N7]
exact_synonym: "Aph1b" [MGI:3522097, UniProt:Q8C7N7]
exact_synonym: "Gamma-secretase subunit APH-1B" [UniProt:Q8C7N7]
xref_analog: UniProt:Q8C7N7
relationship: sequence_of IMR:0001886 ! Aph-1b

[Term]
id: IMR:0001891
name: APH1_CAEEL
exact_synonym: "Anterior-pharynx-defective protein 1" [UniProt:O45876]
exact_synonym: "aph-1" [UniProt:O45876]
exact_synonym: "Gamma-secretase subunit aph-1" [UniProt:O45876]
exact_synonym: "pen-1" [UniProt:O45876]
exact_synonym: "Presenilin enhancer protein 1" [UniProt:O45876]
xref_analog: UniProt:O45876
relationship: sequence_of IMR:0001883 ! Aph-1

[Term]
id: IMR:0001892
name: Pen-2
is_a: IMR:0000429 ! enzyme regulator
relationship: part_of IMR:0001882 ! gamma-secretase complex

[Term]
id: IMR:0001893
name: PEN2_CAEEL
exact_synonym: "Gamma-secretase subunit pen-2" [UniProt:Q9U357]
exact_synonym: "pen-2" [UniProt:Q9U357]
exact_synonym: "Presenilin enhancer protein 2" [UniProt:Q9U357]
xref_analog: UniProt:Q9U357
relationship: sequence_of IMR:0001892 ! Pen-2

[Term]
id: IMR:0001894
name: PEN2_DROME
exact_synonym: "anon-AE003800.1" [FlyBase:FBgn0053198]
exact_synonym: "CG33198" [FlyBase:FBgn0053198]
exact_synonym: "Gamma-secretase subunit pen-2" [UniProt:Q86BE9]
exact_synonym: "pen-2" [FlyBase:FBgn0053198, UniProt:Q86BE9]
exact_synonym: "Pen-2" [FlyBase:FBgn0053198]
exact_synonym: "presenilin enhancer" [FlyBase:FBgn0053198]
exact_synonym: "Presenilin enhancer protein 2" [UniProt:Q86BE9]
xref_analog: UniProt:Q86BE9
relationship: sequence_of IMR:0001892 ! Pen-2

[Term]
id: IMR:0001895
name: PEN2_HUMAN
exact_synonym: "Gamma-secretase subunit PEN-2" [UniProt:Q9NZ42]
exact_synonym: "MSTP064" [EntrezGene:55851]
exact_synonym: "PEN-2" [EntrezGene:55851]
exact_synonym: "PEN2" [EntrezGene:55851, MIM:607632, UniProt:Q9NZ42, HGNC:30100]
exact_synonym: "presenilin enhancer 2 homolog (C. elegans)" [EntrezGene:55851, HGNC:30100]
exact_synonym: "PRESENILIN ENHANCER 2, C. ELEGANS, HOMOLOG OF" [MIM:607632]
exact_synonym: "Presenilin enhancer protein 2" [UniProt:Q9NZ42]
exact_synonym: "PSENEN" [EntrezGene:55851, MIM:607632, UniProt:Q9NZ42, HGNC:30100]
xref_analog: UniProt:Q9NZ42
relationship: sequence_of IMR:0001892 ! Pen-2

[Term]
id: IMR:0001896
name: PEN2_MOUSE
exact_synonym: "Gamma-secretase subunit PEN-2" [UniProt:Q9CQR7]
exact_synonym: "Pen2" [UniProt:Q9CQR7]
exact_synonym: "presenilin enhancer 2 homolog (C. elegans)" [MGI:1913590]
exact_synonym: "Presenilin enhancer protein 2" [UniProt:Q9CQR7]
exact_synonym: "Psenen" [UniProt:Q9CQR7, MGI:1913590]
xref_analog: UniProt:Q9CQR7
relationship: sequence_of IMR:0001892 ! Pen-2

[Term]
id: IMR:0001897
name: HOP1_CAEEL
exact_synonym: "hop-1" [UniProt:O02100]
exact_synonym: "Presenilin hop-1" [UniProt:O02100]
xref_analog: UniProt:O02100
relationship: sequence_of IMR:0000560 ! presenilin

[Term]
id: IMR:0001898
name: PSN_CAEEL
exact_synonym: "Presenilin sel-12" [UniProt:P52166]
exact_synonym: "sel-12" [UniProt:P52166]
exact_synonym: "Suppressor/enhancer of lin-12 protein 12" [UniProt:P52166]
xref_analog: UniProt:P52166
relationship: sequence_of IMR:0000560 ! presenilin

[Term]
id: IMR:0001899
name: SPE4_CAEEL
exact_synonym: "Presenilin spe-4" [UniProt:Q01608]
exact_synonym: "spe-4" [UniProt:Q01608]
xref_analog: UniProt:Q01608
relationship: sequence_of IMR:0000560 ! presenilin

[Term]
id: IMR:0001902
name: PSN_DROME
exact_synonym: "CG18803" [FlyBase:FBgn0019947]
exact_synonym: "CG5868" [FlyBase:FBgn0019947]
exact_synonym: "DmPS" [UniProt:O02194, FlyBase:FBgn0019947]
exact_synonym: "Dpresenilin" [FlyBase:FBgn0019947]
exact_synonym: "dPresenilin" [FlyBase:FBgn0019947]
exact_synonym: "dPS" [UniProt:O02194]
exact_synonym: "DPS" [FlyBase:FBgn0019947]
exact_synonym: "Dps" [FlyBase:FBgn0019947]
exact_synonym: "DPsn" [FlyBase:FBgn0019947]
exact_synonym: "DrosPS" [FlyBase:FBgn0019947]
exact_synonym: "EC 3.4.23.-" [UniProt:O02194]
exact_synonym: "l(3)77CDb" [FlyBase:FBgn0019947]
exact_synonym: "pres" [FlyBase:FBgn0019947]
exact_synonym: "presenilin" [FlyBase:FBgn0019947]
exact_synonym: "Presenilin" [FlyBase:FBgn0019947]
exact_synonym: "Presenilin homolog" [UniProt:O02194]
exact_synonym: "PS" [UniProt:O02194, FlyBase:FBgn0019947]
exact_synonym: "PS1" [FlyBase:FBgn0019947]
exact_synonym: "Psn" [UniProt:O02194, FlyBase:FBgn0019947]
exact_synonym: "psn" [FlyBase:FBgn0019947]
xref_analog: UniProt:O02194
relationship: sequence_of IMR:0000560 ! presenilin

[Term]
id: IMR:0001903
name: F-box/WD40-repeat protein
is_a: IMR:0000429 ! enzyme regulator
relationship: part_of IMR:0100470 ! SCF ubiquitin ligase complex

[Term]
id: IMR:0001904
name: O44382_DROME
exact_synonym: "BcDNA:GM02031" [FlyBase:FBgn0023423]
exact_synonym: "centrosome replication defective" [FlyBase:FBgn0023423]
exact_synonym: "CG3412" [FlyBase:FBgn0023423]
exact_synonym: "crd" [FlyBase:FBgn0023423]
exact_synonym: "ica" [FlyBase:FBgn0023423]
exact_synonym: "icare" [FlyBase:FBgn0023423]
exact_synonym: "l(3)00295" [FlyBase:FBgn0023423]
exact_synonym: "pingiel" [FlyBase:FBgn0023423]
exact_synonym: "shiva" [FlyBase:FBgn0023423]
exact_synonym: "shv" [FlyBase:FBgn0023423]
exact_synonym: "Slimb" [FlyBase:FBgn0023423, UniProt:O44382]
exact_synonym: "slimb" [FlyBase:FBgn0023423, UniProt:O44382]
exact_synonym: "slmb" [FlyBase:FBgn0023423, UniProt:O44382]
exact_synonym: "supernumerary limbs" [FlyBase:FBgn0023423]
xref_analog: UniProt:O44382
relationship: sequence_of IMR:0100471 ! beta-TrCP

[Term]
id: IMR:0001905
name: CUL1_DROME
exact_synonym: "CG1877" [FlyBase:FBgn0015509]
exact_synonym: "cul-1" [UniProt:Q24311, FlyBase:FBgn0015509]
exact_synonym: "Cul-1" [FlyBase:FBgn0015509]
exact_synonym: "cul1" [FlyBase:FBgn0015509]
exact_synonym: "Cul1" [FlyBase:FBgn0015509]
exact_synonym: "CUL1" [FlyBase:FBgn0015509]
exact_synonym: "Cullin homolog 1" [UniProt:Q24311]
exact_synonym: "Cullin1" [FlyBase:FBgn0015509]
exact_synonym: "cullin1" [FlyBase:FBgn0015509]
exact_synonym: "dCul-1" [FlyBase:FBgn0015509]
exact_synonym: "dCul1" [FlyBase:FBgn0015509]
exact_synonym: "dCullin1" [FlyBase:FBgn0015509]
exact_synonym: "l(2)02074" [FlyBase:FBgn0015509]
exact_synonym: "l(2)k01207" [FlyBase:FBgn0015509]
exact_synonym: "Lin-19 homolog protein" [UniProt:Q24311]
exact_synonym: "lin-19-like" [FlyBase:FBgn0015509]
exact_synonym: "lin19" [UniProt:Q24311, FlyBase:FBgn0015509]
exact_synonym: "lin19-like" [FlyBase:FBgn0015509]
xref_analog: UniProt:Q24311
relationship: sequence_of IMR:0100473 ! Cul1

[Term]
id: IMR:0001906
name: RBX1A_DROME
exact_synonym: "anon-EST:Posey65" [FlyBase:FBgn0025638]
exact_synonym: "BEST:CK01110" [FlyBase:FBgn0025638]
exact_synonym: "CG16982" [FlyBase:FBgn0025638]
exact_synonym: "CK01110" [FlyBase:FBgn0025638]
exact_synonym: "dRbx1" [UniProt:Q9W5E1, FlyBase:FBgn0025638]
exact_synonym: "dRoc1a" [FlyBase:FBgn0025638]
exact_synonym: "EG:115C2.11" [FlyBase:FBgn0025638]
exact_synonym: "Rbx1" [FlyBase:FBgn0025638]
exact_synonym: "Rbx1/Roc" [FlyBase:FBgn0025638]
exact_synonym: "Regulator of cullins 1a" [UniProt:Q9W5E1]
exact_synonym: "RING-box protein 1A" [UniProt:Q9W5E1]
exact_synonym: "ROC1" [FlyBase:FBgn0025638]
exact_synonym: "Roc1a" [UniProt:Q9W5E1, FlyBase:FBgn0025638]
exact_synonym: "Roc1alpha" [FlyBase:FBgn0025638]
xref_analog: UniProt:Q9W5E1
relationship: sequence_of IMR:0000971 ! Rbx1

[Term]
id: IMR:0001907
name: RBX1B_DROME
exact_synonym: "BcDNA:AT21612" [FlyBase:FBgn0040291]
exact_synonym: "CG16988" [FlyBase:FBgn0040291]
exact_synonym: "dRoc1b" [FlyBase:FBgn0040291]
exact_synonym: "Regulator of cullins 1b" [UniProt:Q9NHX0]
exact_synonym: "RING-box protein 1B" [UniProt:Q9NHX0]
exact_synonym: "Roc1b" [UniProt:Q9NHX0, FlyBase:FBgn0040291]
exact_synonym: "ROC1b" [FlyBase:FBgn0040291]
exact_synonym: "ROC1B" [FlyBase:FBgn0040291]
exact_synonym: "ROC2" [UniProt:Q9NHX0, FlyBase:FBgn0040291]
xref_analog: UniProt:Q9NHX0
relationship: sequence_of IMR:0000971 ! Rbx1

[Term]
id: IMR:0001908
name: O77430_DROME
exact_synonym: "anon-WO03040301.234" [FlyBase:FBgn0025637]
exact_synonym: "anon-WO03040301.236" [FlyBase:FBgn0025637]
exact_synonym: "anon-WO03040301.238" [FlyBase:FBgn0025637]
exact_synonym: "CG16983" [FlyBase:FBgn0025637]
exact_synonym: "Dredd" [UniProt:O77430]
exact_synonym: "dSkp-1" [FlyBase:FBgn0025637]
exact_synonym: "dskpA" [FlyBase:FBgn0025637]
exact_synonym: "dSkpA" [FlyBase:FBgn0025637]
exact_synonym: "EG:115C2.4" [FlyBase:FBgn0025637, UniProt:O77430]
exact_synonym: "EG:115C2.4 protein" [UniProt:O77430]
exact_synonym: "HL01263p" [UniProt:O77430]
exact_synonym: "l(1)G0037" [FlyBase:FBgn0025637]
exact_synonym: "l(1)G0058" [FlyBase:FBgn0025637]
exact_synonym: "l(1)G0109" [FlyBase:FBgn0025637]
exact_synonym: "l(1)G0389" [FlyBase:FBgn0025637]
exact_synonym: "RH26825p" [UniProt:O77430]
exact_synonym: "SD13881p" [UniProt:O77430]
exact_synonym: "Skp1" [FlyBase:FBgn0025637]
exact_synonym: "skpA" [FlyBase:FBgn0025637, UniProt:O77430]
exact_synonym: "SKPA" [UniProt:O77430]
exact_synonym: "SkpA" [FlyBase:FBgn0025637]
exact_synonym: "SkpA, isoform A" [UniProt:O77430]
exact_synonym: "SkpA, isoform B" [UniProt:O77430]
exact_synonym: "SkpA, isoform C" [UniProt:O77430]
exact_synonym: "SkpA, isoform D" [UniProt:O77430]
exact_synonym: "SkpA, isoform E" [UniProt:O77430]
exact_synonym: "skpA-RC" [UniProt:O77430]
exact_synonym: "skpA-RH" [UniProt:O77430]
exact_synonym: "spkA" [FlyBase:FBgn0025637]
xref_analog: UniProt:O77430
relationship: sequence_of IMR:0100472 ! Skp1

[Term]
id: IMR:0001909
name: SERR_DROME
exact_synonym: "Bd" [UniProt:P18168, FlyBase:FBgn0004197]
exact_synonym: "Beaded" [FlyBase:FBgn0004197]
exact_synonym: "CG6127" [FlyBase:FBgn0004197]
exact_synonym: "CT18858" [FlyBase:FBgn0004197]
exact_synonym: "dmSerrate" [FlyBase:FBgn0004197]
exact_synonym: "mel(3)8" [FlyBase:FBgn0004197]
exact_synonym: "Protein beaded" [UniProt:P18168]
exact_synonym: "Protein serrate" [UniProt:P18168]
exact_synonym: "Ripped wing" [FlyBase:FBgn0004197]
exact_synonym: "Rpw" [FlyBase:FBgn0004197]
exact_synonym: "Ser" [UniProt:P18168, FlyBase:FBgn0004197]
exact_synonym: "ser" [FlyBase:FBgn0004197]
exact_synonym: "serrate" [FlyBase:FBgn0004197]
exact_synonym: "Serrate" [FlyBase:FBgn0004197]
exact_synonym: "serratoid" [FlyBase:FBgn0004197]
exact_synonym: "std" [FlyBase:FBgn0004197]
xref_analog: UniProt:P18168
relationship: sequence_of IMR:0001919 ! Serrate/Jagged

[Term]
id: IMR:0001910
name: Jagged-1
is_a: IMR:0001919 ! Serrate/Jagged

[Term]
id: IMR:0001911
name: JAG1_HUMAN
exact_synonym: "AGS" [EntrezGene:182]
exact_synonym: "AHD" [HGNC:6188, EntrezGene:182]
exact_synonym: "AWS" [HGNC:6188, EntrezGene:182]
exact_synonym: "CD339" [UniProt:P78504, HGNC:6188, EntrezGene:182]
exact_synonym: "hJ1" [UniProt:P78504]
exact_synonym: "HJ1" [HGNC:6188, EntrezGene:182]
exact_synonym: "JAG1" [UniProt:P78504, HGNC:6188, EntrezGene:182]
exact_synonym: "jagged 1" [HGNC:6188, EntrezGene:182]
exact_synonym: "Jagged1" [UniProt:P78504]
exact_synonym: "JAGL1" [UniProt:P78504, EntrezGene:182]
exact_synonym: "MGC104644" [EntrezGene:182]
exact_synonym: "Protein jagged-1" [UniProt:P78504]
xref_analog: UniProt:P78504
relationship: sequence_of IMR:0001910 ! Jagged-1

[Term]
id: IMR:0001912
name: JAG1_MOUSE
exact_synonym: "CD339" [UniProt:Q9QXX0]
exact_synonym: "Headturner" [MGI:1095416]
exact_synonym: "Htu" [MGI:1095416]
exact_synonym: "Jag1" [UniProt:Q9QXX0, MGI:1095416]
exact_synonym: "jagged 1" [MGI:1095416]
exact_synonym: "Jagged1" [UniProt:Q9QXX0]
exact_synonym: "Ozz" [MGI:1095416]
exact_synonym: "Protein jagged-1" [UniProt:Q9QXX0]
exact_synonym: "Serrate-1" [MGI:1095416]
xref_analog: UniProt:Q9QXX0
relationship: sequence_of IMR:0001910 ! Jagged-1

[Term]
id: IMR:0001913
name: JAG1_RAT
exact_synonym: "CD339" [UniProt:Q63722]
exact_synonym: "Jag1" [RGD:2937, UniProt:Q63722]
exact_synonym: "jagged 1" [RGD:2937]
exact_synonym: "Jagged1" [UniProt:Q63722]
exact_synonym: "Protein jagged-1" [UniProt:Q63722]
xref_analog: UniProt:Q63722
relationship: sequence_of IMR:0001910 ! Jagged-1

[Term]
id: IMR:0001914
name: Jagged-2
is_a: IMR:0001919 ! Serrate/Jagged

[Term]
id: IMR:0001915
name: JAG2_HUMAN
exact_synonym: "hJ2" [UniProt:Q9Y219]
exact_synonym: "HJ2" [EntrezGene:3714]
exact_synonym: "JAG2" [MIM:602570, EntrezGene:3714, UniProt:Q9Y219, HGNC:6189]
exact_synonym: "jagged 2" [MIM:602570, EntrezGene:3714, HGNC:6189]
exact_synonym: "Jagged2" [UniProt:Q9Y219]
exact_synonym: "Protein jagged-2" [UniProt:Q9Y219]
exact_synonym: "SER2" [MIM:602570, EntrezGene:3714]
exact_synonym: "SERRATE 2" [MIM:602570]
xref_analog: UniProt:Q9Y219
relationship: sequence_of IMR:0001914 ! Jagged-2

[Term]
id: IMR:0001916
name: JAG2_MOUSE
exact_synonym: "D12Ggc2e" [MGI:1098270]
exact_synonym: "Jag2" [MGI:1098270, UniProt:Q9QYE5]
exact_synonym: "jagged 2" [MGI:1098270]
exact_synonym: "Jagged2" [UniProt:Q9QYE5]
exact_synonym: "Protein jagged-2" [UniProt:Q9QYE5]
exact_synonym: "Serh" [MGI:1098270]
xref_analog: UniProt:Q9QYE5
relationship: sequence_of IMR:0001914 ! Jagged-2

[Term]
id: IMR:0001917
name: JAG2_RAT
exact_synonym: "Jag2" [RGD:2938, UniProt:P97607]
exact_synonym: "jagged 2" [RGD:2938]
exact_synonym: "Jagged2" [UniProt:P97607]
exact_synonym: "Protein jagged-2" [UniProt:P97607]
xref_analog: UniProt:P97607
relationship: sequence_of IMR:0001914 ! Jagged-2

[Term]
id: IMR:0001918
name: LAG2_CAEEL
exact_synonym: "lag-2" [UniProt:P45442]
exact_synonym: "let-461" [UniProt:P45442]
exact_synonym: "Lethal protein 461" [UniProt:P45442]
exact_synonym: "Protein lag-2" [UniProt:P45442]
xref_analog: UniProt:P45442
relationship: sequence_of IMR:0001920 ! DSL ligand

[Term]
id: IMR:0001919
name: Serrate/Jagged
is_a: IMR:0001920 ! DSL ligand

[Term]
id: IMR:0001920
name: DSL ligand
exact_synonym: "Delta/Serrate/Lag-2 family" []
is_a: IMR:0000002 ! ligand

[Term]
id: IMR:0001921
name: LIN12_CAEEL
exact_synonym: "Abnormal cell lineage protein 12" [UniProt:P14585]
exact_synonym: "lin-12" [UniProt:P14585]
exact_synonym: "Protein lin-12" [UniProt:P14585]
xref_analog: UniProt:P14585
relationship: sequence_of IMR:0100712 ! Notch

[Term]
id: IMR:0001922
name: GLP1_CAEEL
exact_synonym: "emb-33" [UniProt:P13508]
exact_synonym: "glp-1" [UniProt:P13508]
exact_synonym: "Protein glp-1" [UniProt:P13508]
xref_analog: UniProt:P13508
relationship: sequence_of IMR:0100712 ! Notch

[Term]
id: IMR:0001923
name: MAM family
exact_synonym: "mastermind family" []
is_a: IMR:0000424 ! transcriptional co-activator

[Term]
id: IMR:0001924
name: MAML1
is_a: IMR:0001923 ! MAM family

[Term]
id: IMR:0001925
name: MAML1_HUMAN
exact_synonym: "FLJ53540" [EntrezGene:9794]
exact_synonym: "KIAA0200" [EntrezGene:9794, UniProt:Q92585, HGNC:13632]
exact_synonym: "Mam-1" [EntrezGene:9794, UniProt:Q92585, HGNC:13632]
exact_synonym: "MAM1" [MIM:605424]
exact_synonym: "Mam1" [EntrezGene:9794]
exact_synonym: "MAML1" [EntrezGene:9794, MIM:605424, UniProt:Q92585, HGNC:13632]
exact_synonym: "MASTERMIND, DROSOPHILA, HOMOLOG OF, 1" [MIM:605424]
exact_synonym: "MASTERMIND-LIKE 1" [MIM:605424]
exact_synonym: "mastermind-like 1 (Drosophila)" [EntrezGene:9794, HGNC:13632]
exact_synonym: "Mastermind-like protein 1" [UniProt:Q92585]
xref_analog: UniProt:Q92585
relationship: sequence_of IMR:0001924 ! MAML1

[Term]
id: IMR:0001926
name: MAML1_MOUSE
exact_synonym: "Kiaa0200" [UniProt:Q6T264]
exact_synonym: "Mam-1" [MGI:1890504, UniProt:Q6T264]
exact_synonym: "Maml1" [MGI:1890504, UniProt:Q6T264]
exact_synonym: "mastermind like 1 (Drosophila)" [MGI:1890504]
exact_synonym: "Mastermind-like protein 1" [UniProt:Q6T264]
xref_analog: UniProt:Q6T264
relationship: sequence_of IMR:0001924 ! MAML1

[Term]
id: IMR:0001927
name: MAML2_HUMAN
exact_synonym: "KIAA1819" [UniProt:Q8IZL2, MIM:607537, HGNC:16259]
exact_synonym: "Mam-2" [UniProt:Q8IZL2]
exact_synonym: "MAM3" [MIM:607537, HGNC:16259]
exact_synonym: "MAML2" [UniProt:Q8IZL2, MIM:607537, HGNC:16259]
exact_synonym: "MASTERMIND, DROSOPHILA, HOMOLOG OF, 3" [MIM:607537]
exact_synonym: "MASTERMIND-LIKE 2" [MIM:607537]
exact_synonym: "mastermind-like 2 (Drosophila)" [HGNC:16259]
exact_synonym: "Mastermind-like protein 2" [UniProt:Q8IZL2]
xref_analog: UniProt:Q8IZL2
relationship: sequence_of IMR:0001923 ! MAM family

[Term]
id: IMR:0001928
name: MAML3_HUMAN
exact_synonym: "CAGH3" [HGNC:16272]
exact_synonym: "GDN" [HGNC:16272]
exact_synonym: "KIAA1816" [MIM:608991, HGNC:16272, UniProt:Q96JK9]
exact_synonym: "Mam-3" [UniProt:Q96JK9]
exact_synonym: "MAM2" [MIM:608991, HGNC:16272]
exact_synonym: "MAML3" [MIM:608991, HGNC:16272, UniProt:Q96JK9]
exact_synonym: "MASTERMIND, DROSOPHILA, HOMOLOG OF, 2" [MIM:608991]
exact_synonym: "MASTERMIND-LIKE 3" [MIM:608991]
exact_synonym: "mastermind-like 3 (Drosophila)" [HGNC:16272]
exact_synonym: "Mastermind-like protein 3" [UniProt:Q96JK9]
xref_analog: UniProt:Q96JK9
relationship: sequence_of IMR:0001923 ! MAM family

[Term]
id: IMR:0001929
name: MAM_DROME
exact_synonym: "CG8118" [FlyBase:FBgn0002643]
exact_synonym: "Dm0064" [FlyBase:FBgn0002643]
exact_synonym: "dMam" [FlyBase:FBgn0002643]
exact_synonym: "l(2)03505" [FlyBase:FBgn0002643]
exact_synonym: "l(2)04615" [FlyBase:FBgn0002643]
exact_synonym: "mam" [FlyBase:FBgn0002643, UniProt:P21519]
exact_synonym: "Mam" [FlyBase:FBgn0002643]
exact_synonym: "mam(CAG)[[7]]" [FlyBase:FBgn0002643]
exact_synonym: "mastermind" [FlyBase:FBgn0002643]
exact_synonym: "N-2G" [FlyBase:FBgn0002643]
exact_synonym: "Neurogenic protein mastermind" [UniProt:P21519]
exact_synonym: "SR2-4" [FlyBase:FBgn0002643]
xref_analog: UniProt:P21519
relationship: sequence_of IMR:0001923 ! MAM family

[Term]
id: IMR:0001930
name: LAG3_CAEEL
exact_synonym: "Abnormal cell lineage protein 3" [UniProt:Q09260]
exact_synonym: "Abnormal germline proliferation protein 3" [UniProt:Q09260]
exact_synonym: "lag-3" [UniProt:Q09260]
exact_synonym: "Protein lag-3" [UniProt:Q09260]
exact_synonym: "sel-8" [UniProt:Q09260]
xref_analog: UniProt:Q09260
relationship: sequence_of IMR:0001923 ! MAM family

[Term]
id: IMR:0001931
name: Sel-10
is_a: IMR:0001903 ! F-box/WD40-repeat protein

[Term]
id: IMR:0001932
name: FBXW7_HUMAN
exact_synonym: "AGO" [HGNC:16712, MIM:606278]
exact_synonym: "Archipelago homolog" [UniProt:Q969H0]
exact_synonym: "ARCHIPELAGO, DROSOPHILA, HOMOLOG OF" [MIM:606278]
exact_synonym: "CDC4" [HGNC:16712]
exact_synonym: "CDC4, S. CEREVISIAE, HOMOLOG OF" [MIM:606278]
exact_synonym: "F-box and WD repeat domain containing 7" [HGNC:16712]
exact_synonym: "F-box and WD-40 domain-containing protein 7" [UniProt:Q969H0]
exact_synonym: "F-BOX AND WD40 DOMAIN PROTEIN 7" [MIM:606278]
exact_synonym: "F-box protein FBX30" [UniProt:Q969H0]
exact_synonym: "F-box/WD repeat-containing protein 7" [UniProt:Q969H0]
exact_synonym: "FBW6" [MIM:606278]
exact_synonym: "FBW7" [HGNC:16712, UniProt:Q969H0, MIM:606278]
exact_synonym: "FBX30" [HGNC:16712, UniProt:Q969H0, MIM:606278]
exact_synonym: "FBXO30" [MIM:606278]
exact_synonym: "FBXW6" [HGNC:16712, MIM:606278]
exact_synonym: "FBXW7" [HGNC:16712, UniProt:Q969H0, MIM:606278]
exact_synonym: "FLJ11071" [HGNC:16712]
exact_synonym: "hAgo" [UniProt:Q969H0]
exact_synonym: "hCdc4" [UniProt:Q969H0]
exact_synonym: "SEL-10" [HGNC:16712, UniProt:Q969H0]
exact_synonym: "SEL10" [HGNC:16712, UniProt:Q969H0, MIM:606278]
exact_synonym: "SEL10, C. ELEGANS, HOMOLOG OF" [MIM:606278]
xref_analog: UniProt:Q969H0
relationship: sequence_of IMR:0001931 ! Sel-10

[Term]
id: IMR:0001933
name: FBXW7_MOUSE
exact_synonym: "AGO" [MGI:1354695]
exact_synonym: "Cdc4" [MGI:1354695]
exact_synonym: "F-box and WD-40 domain protein 7" [MGI:1354695]
exact_synonym: "F-box and WD-40 domain-containing protein 7" [UniProt:Q8VBV4]
exact_synonym: "F-box protein FBW7" [UniProt:Q8VBV4]
exact_synonym: "F-box protein Fbxw6" [UniProt:Q8VBV4]
exact_synonym: "F-box-WD40 repeat protein 6" [UniProt:Q8VBV4]
exact_synonym: "F-box/WD repeat-containing protein 7" [UniProt:Q8VBV4]
exact_synonym: "Fbw7" [MGI:1354695, UniProt:Q8VBV4]
exact_synonym: "Fbwd6" [UniProt:Q8VBV4]
exact_synonym: "Fbxo30" [MGI:1354695]
exact_synonym: "Fbxw6" [MGI:1354695, UniProt:Q8VBV4]
exact_synonym: "Fbxw7" [MGI:1354695, UniProt:Q8VBV4]
exact_synonym: "SEL-10" [MGI:1354695, UniProt:Q8VBV4]
xref_analog: UniProt:Q8VBV4
relationship: sequence_of IMR:0001931 ! Sel-10

[Term]
id: IMR:0001934
name: SEL10_CAEEL
exact_synonym: "Egg laying defective protein 41" [UniProt:Q93794]
exact_synonym: "egl-41" [UniProt:Q93794]
exact_synonym: "F-box/WD repeat-containing protein sel-10" [UniProt:Q93794]
exact_synonym: "sel-10" [UniProt:Q93794]
exact_synonym: "Suppressor/enhancer of lin-12 protein 10" [UniProt:Q93794]
xref_analog: UniProt:Q93794
relationship: sequence_of IMR:0001931 ! Sel-10

[Term]
id: IMR:0001935
name: Deltex
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0001936
name: DTX1_HUMAN
exact_synonym: "deltex homolog 1 (Drosophila)" [HGNC:3060, EntrezGene:1840]
exact_synonym: "DELTEX, DROSOPHILA, HOMOLOG OF, 1" [MIM:602582]
exact_synonym: "Deltex1" [UniProt:Q86Y01]
exact_synonym: "DTX1" [HGNC:3060, EntrezGene:1840, MIM:602582, UniProt:Q86Y01]
exact_synonym: "hDTX1" [UniProt:Q86Y01]
exact_synonym: "hDx-1" [HGNC:3060, EntrezGene:1840]
exact_synonym: "Protein deltex-1" [UniProt:Q86Y01]
xref_analog: UniProt:Q86Y01
relationship: sequence_of IMR:0001935 ! Deltex

[Term]
id: IMR:0001937
name: DTX1_MOUSE
exact_synonym: "deltex 1 homolog (Drosophila)" [MGI:1352744]
exact_synonym: "Deltex1" [UniProt:Q61010]
exact_synonym: "Dtx1" [MGI:1352744, UniProt:Q61010]
exact_synonym: "FXI-T1" [UniProt:Q61010]
exact_synonym: "Fxit1" [MGI:1352744]
exact_synonym: "mDTX1" [UniProt:Q61010]
exact_synonym: "Protein deltex-1" [UniProt:Q61010]
xref_analog: UniProt:Q61010
relationship: sequence_of IMR:0001935 ! Deltex

[Term]
id: IMR:0001938
name: DTX2_HUMAN
exact_synonym: "deltex homolog 2 (Drosophila)" [HGNC:15973, EntrezGene:113878]
exact_synonym: "DELTEX, DROSOPHILA, HOMOLOG OF, 2" [MIM:613141]
exact_synonym: "Deltex2" [UniProt:Q86UW9]
exact_synonym: "DTX2" [UniProt:Q86UW9, HGNC:15973, MIM:613141, EntrezGene:113878]
exact_synonym: "hDTX2" [UniProt:Q86UW9]
exact_synonym: "KIAA1528" [UniProt:Q86UW9, MIM:613141, EntrezGene:113878]
exact_synonym: "MGC71098" [EntrezGene:113878]
exact_synonym: "Protein deltex-2" [UniProt:Q86UW9]
exact_synonym: "RING finger protein 58" [UniProt:Q86UW9]
exact_synonym: "RNF58" [UniProt:Q86UW9, HGNC:15973, EntrezGene:113878]
xref_analog: UniProt:Q86UW9
relationship: sequence_of IMR:0001935 ! Deltex

[Term]
id: IMR:0001939
name: DTX2_MOUSE
exact_synonym: "deltex 2 homolog (Drosophila)" [MGI:1921448]
exact_synonym: "Deltex2" [UniProt:Q8R3P2]
exact_synonym: "Dtx2" [UniProt:Q8R3P2, MGI:1921448]
exact_synonym: "mDTX2" [UniProt:Q8R3P2]
exact_synonym: "Protein deltex-2" [UniProt:Q8R3P2]
xref_analog: UniProt:Q8R3P2
relationship: sequence_of IMR:0001935 ! Deltex

[Term]
id: IMR:0001940
name: DTX3_HUMAN
exact_synonym: "deltex homolog 3 (Drosophila)" [EntrezGene:196403, HGNC:24457]
exact_synonym: "DELTEX, DROSOPHILA, HOMOLOG OF, 3" [MIM:613142]
exact_synonym: "Deltex3" [UniProt:Q8N9I9]
exact_synonym: "DTX3" [EntrezGene:196403, MIM:613142, HGNC:24457, UniProt:Q8N9I9]
exact_synonym: "FLJ34766" [EntrezGene:196403, HGNC:24457]
exact_synonym: "MGC138863" [EntrezGene:196403]
exact_synonym: "MGC138864" [EntrezGene:196403]
exact_synonym: "Protein deltex-3" [UniProt:Q8N9I9]
exact_synonym: "RING finger protein 154" [UniProt:Q8N9I9]
exact_synonym: "RNF154" [EntrezGene:196403, HGNC:24457, UniProt:Q8N9I9]
xref_analog: UniProt:Q8N9I9
relationship: sequence_of IMR:0001935 ! Deltex

[Term]
id: IMR:0001941
name: DTX3_MOUSE
exact_synonym: "deltex 3 homolog (Drosophila)" [MGI:2135752]
exact_synonym: "Deltex3" [UniProt:Q80V91]
exact_synonym: "Dtx3" [UniProt:Q80V91, MGI:2135752]
exact_synonym: "mDTX3" [UniProt:Q80V91]
exact_synonym: "Protein deltex-3" [UniProt:Q80V91]
xref_analog: UniProt:Q80V91
relationship: sequence_of IMR:0001935 ! Deltex

[Term]
id: IMR:0001942
name: DTX_DROME
exact_synonym: "CG3929" [FlyBase:FBgn0000524]
exact_synonym: "deltex" [FlyBase:FBgn0000524]
exact_synonym: "DMDELTEX" [FlyBase:FBgn0000524]
exact_synonym: "dx" [UniProt:Q23985, FlyBase:FBgn0000524]
exact_synonym: "Dx" [FlyBase:FBgn0000524]
exact_synonym: "Protein deltex" [UniProt:Q23985]
xref_analog: UniProt:Q23985
relationship: sequence_of IMR:0001935 ! Deltex

[Term]
id: IMR:0001943
name: Su(dx)/Itch
exact_synonym: "Suppressor of deltex/Itch" []
is_a: IMR:0000329 ! ubiquitin ligase (E3)

[Term]
id: IMR:0001944
name: SUDX_DROME
exact_synonym: "anon-WO0073329.1" [FlyBase:FBgn0003557]
exact_synonym: "anon-WO0073329.2" [FlyBase:FBgn0003557]
exact_synonym: "anon-WO0073329.4" [FlyBase:FBgn0003557]
exact_synonym: "CG4244" [FlyBase:FBgn0003557]
exact_synonym: "E3 ubiquitin-protein ligase Su(dx)" [UniProt:Q9Y0H4]
exact_synonym: "EC 6.3.2.-" [UniProt:Q9Y0H4]
exact_synonym: "Protein suppressor of deltex" [UniProt:Q9Y0H4]
exact_synonym: "Su(deltex)" [FlyBase:FBgn0003557]
exact_synonym: "Su(dx)" [FlyBase:FBgn0003557, UniProt:Q9Y0H4]
exact_synonym: "Su(Dx)" [FlyBase:FBgn0003557]
exact_synonym: "Suppressor of deltex" [FlyBase:FBgn0003557]
xref_analog: UniProt:Q9Y0H4
relationship: sequence_of IMR:0001943 ! Su(dx)/Itch

[Term]
id: IMR:0001945
name: Itch
is_a: IMR:0001943 ! Su(dx)/Itch

[Term]
id: IMR:0001946
name: ITCH_HUMAN
exact_synonym: "AIF4" [EntrezGene:83737]
exact_synonym: "AIP4" [MIM:606409, EntrezGene:83737, UniProt:Q96J02, HGNC:13890]
exact_synonym: "ATROPHIN 1-INTERACTING PROTEIN 4" [MIM:606409]
exact_synonym: "Atrophin-1-interacting protein 4" [UniProt:Q96J02]
exact_synonym: "dJ468O1.1" [EntrezGene:83737]
exact_synonym: "E3 ubiquitin-protein ligase Itchy homolog" [UniProt:Q96J02]
exact_synonym: "EC 6.3.2.-" [UniProt:Q96J02]
exact_synonym: "ITCH" [MIM:606409, EntrezGene:83737, UniProt:Q96J02, HGNC:13890]
exact_synonym: "Itch" [UniProt:Q96J02]
exact_synonym: "itchy E3 ubiquitin protein ligase homolog (mouse)" [EntrezGene:83737, HGNC:13890]
exact_synonym: "ITCHY E3 UBIQUITIN PROTEIN LIGASE, MOUSE, HOMOLOG OF" [MIM:606409]
exact_synonym: "NAPP1" [MIM:606409, EntrezGene:83737, UniProt:Q96J02]
exact_synonym: "NFE2-associated polypeptide 1" [MIM:606409, UniProt:Q96J02]
xref_analog: UniProt:Q96J02
relationship: sequence_of IMR:0001945 ! Itch

[Term]
id: IMR:0001947
name: ITCH_MOUSE
exact_synonym: "AIP4" [MGI:1202301]
exact_synonym: "E3 ubiquitin-protein ligase Itchy" [UniProt:Q8C863]
exact_synonym: "EC 6.3.2.-" [UniProt:Q8C863]
exact_synonym: "Itch" [MGI:1202301, UniProt:Q8C863]
exact_synonym: "itchy, E3 ubiquitin protein ligase" [MGI:1202301]
xref_analog: UniProt:Q8C863
relationship: sequence_of IMR:0001945 ! Itch

[Term]
id: IMR:0001948
name: OAZ
def: "OAZ is a DNA-binding zinc finger protein that associates with Smads in response to BMP2, forming a complex that transcriptionally activates the homeobox regulator of Xenopus mesoderm and neural development, Xvent-2." [PubMed:10660046]
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0001949
name: ZN423_HUMAN
exact_synonym: "Ebfaz" [HGNC:16762, EntrezGene:23090]
exact_synonym: "hOAZ" [UniProt:Q2M1K9]
exact_synonym: "KIAA0760" [MIM:604557, UniProt:Q2M1K9, HGNC:16762, EntrezGene:23090]
exact_synonym: "MGC138520" [EntrezGene:23090]
exact_synonym: "MGC138522" [EntrezGene:23090]
exact_synonym: "OAZ" [MIM:604557, UniProt:Q2M1K9, HGNC:16762, EntrezGene:23090]
exact_synonym: "Olf1/EBF-associated zinc finger protein" [MIM:604557, UniProt:Q2M1K9]
exact_synonym: "Roaz" [HGNC:16762, EntrezGene:23090]
exact_synonym: "Smad- and Olf-interacting zinc finger protein" [UniProt:Q2M1K9]
exact_synonym: "Zfp104" [HGNC:16762, EntrezGene:23090]
exact_synonym: "ZFP423" [MIM:604557, EntrezGene:23090]
exact_synonym: "Zinc finger protein 423" [MIM:604557, UniProt:Q2M1K9]
exact_synonym: "zinc finger protein 423" [HGNC:16762, EntrezGene:23090]
exact_synonym: "ZINC FINGER PROTEIN 423, MOUSE, HOMOLOG OF" [MIM:604557]
exact_synonym: "ZNF423" [MIM:604557, UniProt:Q2M1K9, HGNC:16762, EntrezGene:23090]
xref_analog: UniProt:Q2M1K9
relationship: sequence_of IMR:0001948 ! OAZ

[Term]
id: IMR:0001950
name: chromatin remodeling factor
is_a: IMR:0000424 ! transcriptional co-activator

[Term]
id: IMR:0001951
name: Brg-1
exact_synonym: "Brahma-related gene-1" []
is_a: IMR:0001950 ! chromatin remodeling factor

[Term]
id: IMR:0001952
name: SMCA4_HUMAN
exact_synonym: "ATP-dependent helicase SMARCA4" [UniProt:P51532]
exact_synonym: "BAF190" [HGNC:11100, EntrezGene:6597]
exact_synonym: "BAF190A" [UniProt:P51532]
exact_synonym: "BRG1" [HGNC:11100, EntrezGene:6597, UniProt:P51532, MIM:603254]
exact_synonym: "BRG1-associated factor 190A" [UniProt:P51532]
exact_synonym: "BRM/SWI2-RELATED GENE 1" [MIM:603254]
exact_synonym: "EC 3.6.4.-" [UniProt:P51532]
exact_synonym: "FLJ39786" [HGNC:11100, EntrezGene:6597]
exact_synonym: "hSNF2b" [HGNC:11100, EntrezGene:6597]
exact_synonym: "Mitotic growth and transcription activator" [UniProt:P51532]
exact_synonym: "Protein brahma homolog 1" [UniProt:P51532]
exact_synonym: "Protein BRG-1" [UniProt:P51532]
exact_synonym: "RTPS2" [EntrezGene:6597]
exact_synonym: "SMARCA4" [HGNC:11100, EntrezGene:6597, UniProt:P51532, MIM:603254]
exact_synonym: "SNF2" [HGNC:11100, EntrezGene:6597]
exact_synonym: "SNF2-beta" [UniProt:P51532, MIM:603254]
exact_synonym: "SNF2-BETA" [HGNC:11100, EntrezGene:6597]
exact_synonym: "SNF2B" [UniProt:P51532]
exact_synonym: "SNF2L4" [EntrezGene:6597, UniProt:P51532]
exact_synonym: "SNF2LB" [HGNC:11100, EntrezGene:6597]
exact_synonym: "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4" [HGNC:11100, EntrezGene:6597]
exact_synonym: "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4" [UniProt:P51532]
exact_synonym: "SWI/SNF-RELATED, MATRIX-ASSOCIATED, ACTIN-DEPENDENT REGULATOR OF CHROMATIN, SUBFAMILY A, MEMBER 4" [MIM:603254]
exact_synonym: "SWI2" [HGNC:11100, EntrezGene:6597]
exact_synonym: "Transcription activator BRG1" [UniProt:P51532]
xref_analog: UniProt:P51532
relationship: sequence_of IMR:0001951 ! Brg-1

[Term]
id: IMR:0001953
name: RhoA
is_a: IMR:0000296 ! Rho

[Term]
id: IMR:0001954
name: RhoGEF
exact_synonym: "Rho guanine nucleotide exchange factor" []
xref_analog: GO:0005089
is_a: IMR:0000433 ! GEF

[Term]
id: IMR:0001955
name: Numb
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0001956
name: NUMB_DROME
exact_synonym: "CG3779" [FlyBase:FBgn0002973]
exact_synonym: "d-numb" [FlyBase:FBgn0002973]
exact_synonym: "d-Numb" [FlyBase:FBgn0002973]
exact_synonym: "dNumb" [FlyBase:FBgn0002973]
exact_synonym: "l(2)03235" [FlyBase:FBgn0002973]
exact_synonym: "l(2)3235" [FlyBase:FBgn0002973]
exact_synonym: "l(2)s2201" [FlyBase:FBgn0002973]
exact_synonym: "N7-1" [FlyBase:FBgn0002973]
exact_synonym: "nb" [FlyBase:FBgn0002973]
exact_synonym: "numb" [FlyBase:FBgn0002973, UniProt:P16554]
exact_synonym: "Numb" [FlyBase:FBgn0002973]
exact_synonym: "Protein numb" [UniProt:P16554]
xref_analog: UniProt:P16554
relationship: sequence_of IMR:0001955 ! Numb

[Term]
id: IMR:0001957
name: NUMB_HUMAN
exact_synonym: "h-Numb" [UniProt:P49757]
exact_synonym: "NUMB" [HGNC:8060, MIM:603728, EntrezGene:8650, UniProt:P49757]
exact_synonym: "numb homolog (Drosophila)" [HGNC:8060, EntrezGene:8650]
exact_synonym: "NUMB, DROSOPHILA, HOMOLOG OF" [MIM:603728]
exact_synonym: "Protein numb homolog" [UniProt:P49757]
exact_synonym: "Protein S171" [UniProt:P49757]
exact_synonym: "S171" [EntrezGene:8650]
xref_analog: UniProt:P49757
relationship: sequence_of IMR:0001955 ! Numb

[Term]
id: IMR:0001958
name: NUMB_MOUSE
exact_synonym: "m-Nb" [UniProt:Q9QZS3]
exact_synonym: "m-Numb" [UniProt:Q9QZS3]
exact_synonym: "m-numb" [MGI:107423]
exact_synonym: "Numb" [MGI:107423, UniProt:Q9QZS3]
exact_synonym: "numb gene homolog (Drosophila)" [MGI:107423]
exact_synonym: "Protein numb homolog" [UniProt:Q9QZS3]
xref_analog: UniProt:Q9QZS3
relationship: sequence_of IMR:0001955 ! Numb

[Term]
id: IMR:0001959
name: Nrarp
exact_synonym: "Notch-regulated ankyrin repeat protein" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0001960
name: NRARP_MOUSE
exact_synonym: "Notch-regulated ankyrin repeat protein" [MGI:1914372]
exact_synonym: "Notch-regulated ankyrin repeat-containing protein" [UniProt:Q91ZA8]
exact_synonym: "Nrarp" [UniProt:Q91ZA8, MGI:1914372]
xref_analog: UniProt:Q91ZA8
relationship: sequence_of IMR:0001959 ! Nrarp

[Term]
id: IMR:0001961
name: MINT
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0001962
name: MINT_HUMAN
exact_synonym: "HIAA0929" [EntrezGene:23013]
exact_synonym: "KIAA0929" [MIM:613484, HGNC:17575, UniProt:Q96T58, EntrezGene:23013]
exact_synonym: "MINT" [MIM:613484, HGNC:17575, UniProt:Q96T58, EntrezGene:23013]
exact_synonym: "MSX2-INTERACTING NUCLEAR TARGET" [MIM:613484]
exact_synonym: "Msx2-interacting protein" [UniProt:Q96T58]
exact_synonym: "RBM15C" [HGNC:17575, EntrezGene:23013]
exact_synonym: "SHARP" [MIM:613484, HGNC:17575, UniProt:Q96T58, EntrezGene:23013]
exact_synonym: "SMART/HDAC1-associated repressor protein" [MIM:613484, UniProt:Q96T58]
exact_synonym: "SPEN" [MIM:613484, HGNC:17575, UniProt:Q96T58, EntrezGene:23013]
exact_synonym: "SPEN homolog" [UniProt:Q96T58]
exact_synonym: "spen homolog, transcriptional regulator (Drosophila)" [HGNC:17575, EntrezGene:23013]
exact_synonym: "SPEN, DROSOPHILA, HOMOLOG OF" [MIM:613484]
xref_analog: UniProt:Q96T58
relationship: sequence_of IMR:0001961 ! MINT

[Term]
id: IMR:0001963
name: MINT_MOUSE
exact_synonym: "Kiaa0929" [UniProt:Q62504]
exact_synonym: "Mint" [MGI:1891706, UniProt:Q62504]
exact_synonym: "Msx2-interacting protein" [UniProt:Q62504]
exact_synonym: "Sharp" [UniProt:Q62504]
exact_synonym: "SMART/HDAC1-associated repressor protein" [UniProt:Q62504]
exact_synonym: "Spen" [MGI:1891706, UniProt:Q62504]
exact_synonym: "SPEN homolog" [UniProt:Q62504]
exact_synonym: "SPEN homolog, transcriptional regulator (Drosophila)" [MGI:1891706]
xref_analog: UniProt:Q62504
relationship: sequence_of IMR:0001961 ! MINT

[Term]
id: IMR:0001964
name: CD19
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0001965
name: CD19_HUMAN
exact_synonym: "B-lymphocyte antigen CD19" [UniProt:P15391, MIM:107265]
exact_synonym: "B-lymphocyte surface antigen B4" [UniProt:P15391]
exact_synonym: "B4" [EntrezGene:930]
exact_synonym: "CD19" [UniProt:P15391, MIM:107265, EntrezGene:930, HGNC:1633]
exact_synonym: "CD19 ANTIGEN" [MIM:107265]
exact_synonym: "CD19 molecule" [EntrezGene:930, HGNC:1633]
exact_synonym: "CVID3" [EntrezGene:930]
exact_synonym: "Differentiation antigen CD19" [UniProt:P15391]
exact_synonym: "MGC12802" [EntrezGene:930]
exact_synonym: "T-cell surface antigen Leu-12" [UniProt:P15391]
xref_analog: UniProt:P15391
relationship: sequence_of IMR:0001964 ! CD19

[Term]
id: IMR:0001966
name: CD19_MOUSE
exact_synonym: "B-lymphocyte antigen CD19" [UniProt:P25918]
exact_synonym: "Cd19" [MGI:88319, UniProt:P25918]
exact_synonym: "CD19" [UniProt:P25918]
exact_synonym: "CD19 antigen" [MGI:88319]
exact_synonym: "Differentiation antigen CD19" [UniProt:P25918]
xref_analog: UniProt:P25918
relationship: sequence_of IMR:0001964 ! CD19

[Term]
id: IMR:0001967
name: Epac
def: "Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) are closely related guanine nucleotide exchange factors (GEFs) for the small GTPase Rap1 and Rap2, which are directly regulated by cAMP." [PubMed:9856955]
exact_synonym: "exchange protein directly activated by cAMP" []
is_a: IMR:0001976 ! RapGEF

[Term]
id: IMR:0001968
name: Epac1
exact_synonym: "cAMP-GEFI" []
exact_synonym: "Epac" []
is_a: IMR:0001967 ! Epac

[Term]
id: IMR:0001969
name: Epac2
exact_synonym: "cAMP-GEFII" []
is_a: IMR:0001967 ! Epac

[Term]
id: IMR:0001970
name: RPGF3_HUMAN
exact_synonym: "bcm910" [EntrezGene:10411, HGNC:16629]
exact_synonym: "cAMP-GEFI" [UniProt:O95398, MIM:606057, HGNC:16629]
exact_synonym: "CAMP-GEFI" [EntrezGene:10411]
exact_synonym: "cAMP-regulated guanine nucleotide exchange factor I" [UniProt:O95398, MIM:606057]
exact_synonym: "CGEF1" [UniProt:O95398]
exact_synonym: "EPAC" [UniProt:O95398, EntrezGene:10411, MIM:606057, HGNC:16629]
exact_synonym: "EPAC 1" [UniProt:O95398]
exact_synonym: "EPAC1" [UniProt:O95398, EntrezGene:10411, MIM:606057]
exact_synonym: "Exchange factor directly activated by cAMP 1" [UniProt:O95398]
exact_synonym: "EXCHANGE PROTEIN ACTIVATED BY cAMP" [MIM:606057]
exact_synonym: "Exchange protein directly activated by cAMP 1" [UniProt:O95398]
exact_synonym: "HSU79275" [EntrezGene:10411]
exact_synonym: "MGC21410" [EntrezGene:10411]
exact_synonym: "Rap guanine nucleotide exchange factor (GEF) 3" [EntrezGene:10411, HGNC:16629]
exact_synonym: "Rap guanine nucleotide exchange factor 3" [UniProt:O95398, MIM:606057]
exact_synonym: "Rap1 guanine-nucleotide-exchange factor directly activated by cAMP" [UniProt:O95398]
exact_synonym: "RAPGEF3" [UniProt:O95398, EntrezGene:10411, MIM:606057, HGNC:16629]
xref_analog: UniProt:O95398
relationship: sequence_of IMR:0001968 ! Epac1

[Term]
id: IMR:0001971
name: RPGF3_MOUSE
exact_synonym: "cAMP-GEFI" [UniProt:Q8VCC8]
exact_synonym: "cAMP-regulated guanine nucleotide exchange factor I" [UniProt:Q8VCC8]
exact_synonym: "Epac" [UniProt:Q8VCC8]
exact_synonym: "EPAC 1" [UniProt:Q8VCC8]
exact_synonym: "Epac1" [MGI:2441741, UniProt:Q8VCC8]
exact_synonym: "Exchange factor directly activated by cAMP 1" [UniProt:Q8VCC8]
exact_synonym: "Exchange protein directly activated by cAMP 1" [UniProt:Q8VCC8]
exact_synonym: "Rap guanine nucleotide exchange factor (GEF) 3" [MGI:2441741]
exact_synonym: "Rap guanine nucleotide exchange factor 3" [UniProt:Q8VCC8]
exact_synonym: "Rapgef3" [MGI:2441741, UniProt:Q8VCC8]
xref_analog: UniProt:Q8VCC8
relationship: sequence_of IMR:0001968 ! Epac1

[Term]
id: IMR:0001972
name: RPGF3_RAT
xref_analog: UniProt:Q9Z1C
relationship: sequence_of IMR:0001968 ! Epac1

[Term]
id: IMR:0001973
name: RPGF4_HUMAN
exact_synonym: "cAMP-GEFII" [UniProt:Q8WZA2, HGNC:16626, MIM:606058]
exact_synonym: "CAMP-GEFII" [EntrezGene:11069]
exact_synonym: "cAMP-regulated guanine nucleotide exchange factor II" [UniProt:Q8WZA2, MIM:606058]
exact_synonym: "CGEF2" [UniProt:Q8WZA2, HGNC:16626, EntrezGene:11069]
exact_synonym: "EPAC 2" [UniProt:Q8WZA2]
exact_synonym: "EPAC2" [UniProt:Q8WZA2, MIM:606058, EntrezGene:11069]
exact_synonym: "Exchange factor directly activated by cAMP 2" [UniProt:Q8WZA2]
exact_synonym: "Exchange protein directly activated by cAMP 2" [UniProt:Q8WZA2]
exact_synonym: "Nbla00496" [EntrezGene:11069]
exact_synonym: "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR" [MIM:606058]
exact_synonym: "Rap guanine nucleotide exchange factor (GEF) 4" [HGNC:16626, EntrezGene:11069]
exact_synonym: "Rap guanine nucleotide exchange factor 4" [UniProt:Q8WZA2]
exact_synonym: "RAPGEF4" [UniProt:Q8WZA2, HGNC:16626, MIM:606058, EntrezGene:11069]
xref_analog: UniProt:Q8WZA2
relationship: sequence_of IMR:0001969 ! Epac2

[Term]
id: IMR:0001974
name: RPGF4_MOUSE
exact_synonym: "cAMP-dependent Rap1 guanine-nucleotide exchange factor" [UniProt:Q9EQZ6]
exact_synonym: "cAMP-GEFII" [MGI:1917723, UniProt:Q9EQZ6]
exact_synonym: "cAMP-regulated guanine nucleotide exchange factor II" [UniProt:Q9EQZ6]
exact_synonym: "Cgef2" [UniProt:Q9EQZ6]
exact_synonym: "EPAC 2" [UniProt:Q9EQZ6]
exact_synonym: "Epac2" [MGI:1917723, UniProt:Q9EQZ6]
exact_synonym: "Exchange factor directly activated by cAMP 2" [UniProt:Q9EQZ6]
exact_synonym: "Exchange protein directly activated by cAMP 2" [UniProt:Q9EQZ6]
exact_synonym: "Rap guanine nucleotide exchange factor (GEF) 4" [MGI:1917723]
exact_synonym: "Rap guanine nucleotide exchange factor 4" [UniProt:Q9EQZ6]
exact_synonym: "Rapgef4" [MGI:1917723, UniProt:Q9EQZ6]
xref_analog: UniProt:Q9EQZ6
relationship: sequence_of IMR:0001969 ! Epac2

[Term]
id: IMR:0001975
name: RPGF4_RAT
exact_synonym: "cAMP-GEFII" [UniProt:Q9Z1C7]
exact_synonym: "cAMP-regulated guanine nucleotide exchange factor II" [UniProt:Q9Z1C7]
exact_synonym: "Cgef2" [UniProt:Q9Z1C7]
exact_synonym: "EPAC 2" [UniProt:Q9Z1C7]
exact_synonym: "Epac2" [UniProt:Q9Z1C7]
exact_synonym: "Exchange factor directly activated by cAMP 2" [UniProt:Q9Z1C7]
exact_synonym: "Exchange protein directly activated by cAMP 2" [UniProt:Q9Z1C7]
exact_synonym: "Rap guanine nucleotide exchange factor (GEF) 4" [RGD:621886]
exact_synonym: "Rap guanine nucleotide exchange factor 4" [UniProt:Q9Z1C7]
exact_synonym: "Rapgef4" [RGD:621886, UniProt:Q9Z1C7]
xref_analog: UniProt:Q9Z1C7
relationship: sequence_of IMR:0001969 ! Epac2

[Term]
id: IMR:0001976
name: RapGEF
exact_synonym: "Rap guanine nucleotide exchange factor" []
xref_analog: GO:0017034
is_a: IMR:0100440 ! RasGEF

[Term]
id: IMR:0001977
name: O44353_CAEEL
exact_synonym: "end-1" [UniProt:O44353]
exact_synonym: "GATA transcription factor END-1" [UniProt:O44353]
exact_synonym: "Protein F58E10.2, partially confirmed by transcript evidence" [UniProt:O44353]
xref_analog: UniProt:O44353
relationship: sequence_of IMR:0000410 ! GATA

[Term]
id: IMR:0001978
name: UBX_DROME
exact_synonym: "abx" [FlyBase:FBgn0003944]
exact_synonym: "anterobithorax" [FlyBase:FBgn0003944]
exact_synonym: "bithorax" [FlyBase:FBgn0003944]
exact_synonym: "bithoraxoid" [FlyBase:FBgn0003944]
exact_synonym: "bx" [FlyBase:FBgn0003944]
exact_synonym: "BX-C" [FlyBase:FBgn0003944]
exact_synonym: "bx[D]" [FlyBase:FBgn0003944]
exact_synonym: "bxd" [FlyBase:FBgn0003944]
exact_synonym: "bxd[D]" [FlyBase:FBgn0003944]
exact_synonym: "Bxl" [FlyBase:FBgn0003944]
exact_synonym: "bxl" [FlyBase:FBgn0003944]
exact_synonym: "Cbx" [FlyBase:FBgn0003944]
exact_synonym: "CG10388" [FlyBase:FBgn0003944]
exact_synonym: "Contrabithorax" [FlyBase:FBgn0003944]
exact_synonym: "DmUbx" [FlyBase:FBgn0003944]
exact_synonym: "DUbx" [FlyBase:FBgn0003944]
exact_synonym: "Haltere mimic" [FlyBase:FBgn0003944]
exact_synonym: "Hm" [FlyBase:FBgn0003944]
exact_synonym: "Homeotic protein ultrabithorax" [UniProt:P83949]
exact_synonym: "l(3)89Eb" [FlyBase:FBgn0003944]
exact_synonym: "pbx" [FlyBase:FBgn0003944]
exact_synonym: "postbithorax" [FlyBase:FBgn0003944]
exact_synonym: "Ubx" [FlyBase:FBgn0003944, UniProt:P83949]
exact_synonym: "UBx" [FlyBase:FBgn0003944]
exact_synonym: "ubx" [FlyBase:FBgn0003944]
exact_synonym: "Ubx1b" [FlyBase:FBgn0003944]
exact_synonym: "Ultraabdominal" [FlyBase:FBgn0003944]
exact_synonym: "Ultrabithorax" [FlyBase:FBgn0003944]
xref_analog: UniProt:P83949
relationship: sequence_of IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0001979
name: HMEN_DROME
exact_synonym: "Apa" [FlyBase:FBgn0000577]
exact_synonym: "Apigmented abdomen" [FlyBase:FBgn0000577]
exact_synonym: "CG9015" [FlyBase:FBgn0000577]
exact_synonym: "en" [UniProt:P02836, FlyBase:FBgn0000577]
exact_synonym: "Eng" [FlyBase:FBgn0000577]
exact_synonym: "engrailed" [FlyBase:FBgn0000577]
exact_synonym: "Engrailed/Invected" [FlyBase:FBgn0000577]
exact_synonym: "Erased" [FlyBase:FBgn0000577]
exact_synonym: "Es" [FlyBase:FBgn0000577]
exact_synonym: "Segmentation polarity homeobox protein engrailed" [UniProt:P02836]
exact_synonym: "spermatheca" [FlyBase:FBgn0000577]
exact_synonym: "spt" [FlyBase:FBgn0000577]
exact_synonym: "transcript group V" [FlyBase:FBgn0000577]
exact_synonym: "V" [FlyBase:FBgn0000577]
xref_analog: UniProt:P02836
relationship: sequence_of IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0001980
name: HES/E(spl)
exact_synonym: "hairy and Enhancer of split/Enhancer of split" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0001981
name: DECA_DROME
exact_synonym: "blink" [FlyBase:FBgn0000490]
exact_synonym: "blk" [FlyBase:FBgn0000490]
exact_synonym: "BMP" [FlyBase:FBgn0000490]
exact_synonym: "CG9885" [FlyBase:FBgn0000490]
exact_synonym: "decapentaplegic" [FlyBase:FBgn0000490]
exact_synonym: "Dm-DPP" [FlyBase:FBgn0000490]
exact_synonym: "dpp" [FlyBase:FBgn0000490, UniProt:P07713]
exact_synonym: "DPP" [FlyBase:FBgn0000490]
exact_synonym: "Dpp" [FlyBase:FBgn0000490]
exact_synonym: "DPP-C" [FlyBase:FBgn0000490]
exact_synonym: "Haplo-insufficient" [FlyBase:FBgn0000490]
exact_synonym: "heldout" [FlyBase:FBgn0000490]
exact_synonym: "Hin-d" [FlyBase:FBgn0000490]
exact_synonym: "ho" [FlyBase:FBgn0000490]
exact_synonym: "l(2)10638" [FlyBase:FBgn0000490]
exact_synonym: "l(2)22Fa" [FlyBase:FBgn0000490]
exact_synonym: "l(2)k17036" [FlyBase:FBgn0000490]
exact_synonym: "M(2)23AB" [FlyBase:FBgn0000490]
exact_synonym: "M(2)LS1" [FlyBase:FBgn0000490]
exact_synonym: "Protein decapentaplegic" [UniProt:P07713]
exact_synonym: "Protein DPP-C" [UniProt:P07713]
exact_synonym: "shortvein" [FlyBase:FBgn0000490]
exact_synonym: "shv" [FlyBase:FBgn0000490]
exact_synonym: "Tegula" [FlyBase:FBgn0000490]
exact_synonym: "Tg" [FlyBase:FBgn0000490]
exact_synonym: "TGF-b" [FlyBase:FBgn0000490]
exact_synonym: "TGF-beta" [FlyBase:FBgn0000490]
exact_synonym: "TGFbeta" [FlyBase:FBgn0000490]
xref_analog: UniProt:P07713
relationship: sequence_of IMR:0003083 ! BMP-2 subfamily

[Term]
id: IMR:0001982
name: APC_XENLA
exact_synonym: "Adenomatous polyposis coli homolog" [UniProt:P70039]
exact_synonym: "apc" [UniProt:P70039]
exact_synonym: "Protein APC" [UniProt:P70039]
xref_analog: UniProt:P70039
relationship: sequence_of IMR:0000205 ! APC

[Term]
id: IMR:0001983
name: Q91757_XENLA
exact_synonym: "gsk3b" [UniProt:Q91757]
exact_synonym: "Intracellular kinase" [UniProt:Q91757]
exact_synonym: "Xgsk-3" [UniProt:Q91757]
exact_synonym: "Xgsk-3 protein" [UniProt:Q91757]
xref_analog: UniProt:Q91757
relationship: sequence_of IMR:0000257 ! GSK3

[Term]
id: IMR:0001984
name: Q9I902_XENLA
exact_synonym: "Beta-catenin-interacting protein" [UniProt:Q9I902]
exact_synonym: "ctnnbip1" [UniProt:Q9I902]
exact_synonym: "ctnnbip1a" [UniProt:Q9I902]
exact_synonym: "Ctnnbip1a protein" [UniProt:Q9I902]
exact_synonym: "ICAT" [UniProt:Q9I902]
xref_analog: UniProt:Q9I902
relationship: sequence_of IMR:0001161 ! ICAT

[Term]
id: IMR:0001985
name: ICAM1_HUMAN
exact_synonym: "ANTIGEN IDENTIFIED BY MONOCLONAL ANTIBODY BB2" [MIM:147840]
exact_synonym: "BB2" [MIM:147840, EntrezGene:3383, HGNC:5344]
exact_synonym: "CD54" [UniProt:P05362, MIM:147840, EntrezGene:3383, HGNC:5344]
exact_synonym: "ICAM-1" [UniProt:P05362]
exact_synonym: "ICAM1" [UniProt:P05362, MIM:147840, EntrezGene:3383, HGNC:5344]
exact_synonym: "Intercellular adhesion molecule 1" [UniProt:P05362, MIM:147840]
exact_synonym: "intercellular adhesion molecule 1" [EntrezGene:3383, HGNC:5344]
exact_synonym: "Major group rhinovirus receptor" [UniProt:P05362]
exact_synonym: "P3.58" [EntrezGene:3383]
exact_synonym: "SURFACE ANTIGEN OF ACTIVATED B CELLS, BB2" [MIM:147840]
xref_analog: UniProt:P05362
relationship: sequence_of IMR:0000618 ! ICAM-1

[Term]
id: IMR:0001986
name: ICAM1_MOUSE
exact_synonym: "CD54" [MGI:96392, UniProt:P13597]
exact_synonym: "Icam-1" [MGI:96392, UniProt:P13597]
exact_synonym: "ICAM-1" [UniProt:P13597]
exact_synonym: "Icam1" [MGI:96392, UniProt:P13597]
exact_synonym: "Intercellular adhesion molecule 1" [UniProt:P13597]
exact_synonym: "intercellular adhesion molecule 1" [MGI:96392]
exact_synonym: "Ly-47" [MGI:96392]
exact_synonym: "MALA-2" [MGI:96392, UniProt:P13597]
exact_synonym: "MyD10" [UniProt:P13597]
xref_analog: UniProt:P13597
relationship: sequence_of IMR:0000618 ! ICAM-1

[Term]
id: IMR:0001987
name: ICAM1_RAT
exact_synonym: "CD54" [UniProt:Q00238]
exact_synonym: "Icam-1" [UniProt:Q00238]
exact_synonym: "ICAM-1" [UniProt:Q00238]
exact_synonym: "Icam1" [RGD:2857, UniProt:Q00238]
exact_synonym: "Intercellular adhesion molecule 1" [UniProt:Q00238]
exact_synonym: "intercellular adhesion molecule 1" [RGD:2857]
xref_analog: UniProt:Q00238
relationship: sequence_of IMR:0000618 ! ICAM-1

[Term]
id: IMR:0001988
name: ICAM2_HUMAN
exact_synonym: "CD102" [UniProt:P13598, HGNC:5345]
exact_synonym: "ICAM-2" [UniProt:P13598]
exact_synonym: "ICAM2" [UniProt:P13598, HGNC:5345, MIM:146630]
exact_synonym: "Intercellular adhesion molecule 2" [UniProt:P13598, MIM:146630]
exact_synonym: "intercellular adhesion molecule 2" [HGNC:5345]
xref_analog: UniProt:P13598
relationship: sequence_of IMR:0000619 ! ICAM-2

[Term]
id: IMR:0001989
name: ICAM2_MOUSE
exact_synonym: "CD102" [UniProt:P35330, MGI:96394]
exact_synonym: "Icam-2" [UniProt:P35330, MGI:96394]
exact_synonym: "ICAM-2" [UniProt:P35330]
exact_synonym: "Icam2" [UniProt:P35330, MGI:96394]
exact_synonym: "Intercellular adhesion molecule 2" [UniProt:P35330]
exact_synonym: "intercellular adhesion molecule 2" [MGI:96394]
exact_synonym: "Lymphocyte function-associated AG-1 counter-receptor" [UniProt:P35330]
xref_analog: UniProt:P35330
relationship: sequence_of IMR:0000619 ! ICAM-2

[Term]
id: IMR:0001990
name: ICAM3_HUMAN
exact_synonym: "CD50" [HGNC:5346, UniProt:P32942]
exact_synonym: "CDw50" [UniProt:P32942]
exact_synonym: "CDW50" [HGNC:5346]
exact_synonym: "ICAM-3" [UniProt:P32942]
exact_synonym: "ICAM-R" [HGNC:5346, UniProt:P32942]
exact_synonym: "ICAM3" [MIM:146631, HGNC:5346, UniProt:P32942]
exact_synonym: "Intercellular adhesion molecule 3" [MIM:146631, UniProt:P32942]
exact_synonym: "intercellular adhesion molecule 3" [HGNC:5346]
xref_analog: UniProt:P32942
relationship: sequence_of IMR:0000620 ! ICAM-3

[Term]
id: IMR:0001991
name: ICAM4_HUMAN
exact_synonym: "CD242" [UniProt:Q14773, HGNC:5347, EntrezGene:3386]
exact_synonym: "ICAM-4" [UniProt:Q14773]
exact_synonym: "ICAM4" [UniProt:Q14773, HGNC:5347, EntrezGene:3386]
exact_synonym: "Intercellular adhesion molecule 4" [UniProt:Q14773]
exact_synonym: "intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)" [HGNC:5347, EntrezGene:3386]
exact_synonym: "Landsteiner-Wiener blood group glycoprotein" [UniProt:Q14773]
exact_synonym: "LW" [UniProt:Q14773, EntrezGene:3386]
exact_synonym: "LW blood group protein" [UniProt:Q14773]
xref_analog: UniProt:Q14773
relationship: sequence_of IMR:0000621 ! ICAM-4

[Term]
id: IMR:0001992
name: ICAM4_MOUSE
exact_synonym: "CD242" [UniProt:Q9ERM2]
exact_synonym: "Cd242" [MGI:1925619]
exact_synonym: "ICAM-4" [UniProt:Q9ERM2]
exact_synonym: "Icam4" [MGI:1925619, UniProt:Q9ERM2]
exact_synonym: "Intercellular adhesion molecule 4" [UniProt:Q9ERM2]
exact_synonym: "intercellular adhesion molecule 4, Landsteiner-Wiener blood group" [MGI:1925619]
xref_analog: UniProt:Q9ERM2
relationship: sequence_of IMR:0000621 ! ICAM-4

[Term]
id: IMR:0001993
name: ICAM5_HUMAN
exact_synonym: "ICAM-5" [UniProt:Q9UMF0]
exact_synonym: "ICAM5" [HGNC:5348, EntrezGene:7087, UniProt:Q9UMF0, MIM:601852]
exact_synonym: "Intercellular adhesion molecule 5" [UniProt:Q9UMF0, MIM:601852]
exact_synonym: "intercellular adhesion molecule 5, telencephalin" [HGNC:5348, EntrezGene:7087]
exact_synonym: "Telencephalin" [UniProt:Q9UMF0, MIM:601852]
exact_synonym: "TLCN" [EntrezGene:7087, UniProt:Q9UMF0, MIM:601852]
exact_synonym: "TLN" [HGNC:5348, EntrezGene:7087, UniProt:Q9UMF0, MIM:601852]
xref_analog: UniProt:Q9UMF0
relationship: sequence_of IMR:0000622 ! ICAM-5

[Term]
id: IMR:0001994
name: ICAM5_MOUSE
exact_synonym: "CD50" [MGI:109430]
exact_synonym: "ICAM-5" [UniProt:Q60625]
exact_synonym: "Icam3" [UniProt:Q60625, MGI:109430]
exact_synonym: "Icam5" [UniProt:Q60625, MGI:109430]
exact_synonym: "Intercellular adhesion molecule 5" [UniProt:Q60625]
exact_synonym: "intercellular adhesion molecule 5, telencephalin" [MGI:109430]
exact_synonym: "Telencephalin" [UniProt:Q60625]
exact_synonym: "Tlcn" [UniProt:Q60625, MGI:109430]
exact_synonym: "TLN" [MGI:109430]
xref_analog: UniProt:Q60625
relationship: sequence_of IMR:0000622 ! ICAM-5

[Term]
id: IMR:0001995
name: COPZ2_HUMAN
exact_synonym: "coatomer protein complex, subunit zeta 2" [HGNC:19356, EntrezGene:51226]
exact_synonym: "Coatomer subunit zeta-2" [UniProt:Q9P299]
exact_synonym: "COPZ2" [UniProt:Q9P299, HGNC:19356, EntrezGene:51226]
exact_synonym: "MGC23008" [HGNC:19356, EntrezGene:51226]
exact_synonym: "Zeta-2 COP" [UniProt:Q9P299]
exact_synonym: "Zeta-2-coat protein" [UniProt:Q9P299]
xref_analog: UniProt:Q9P299
relationship: sequence_of IMR:0000665 ! zeta-2 COP

[Term]
id: IMR:0001996
name: COPZ2_MOUSE
exact_synonym: "coatomer protein complex, subunit zeta 2" [MGI:1929008]
exact_synonym: "Coatomer subunit zeta-2" [UniProt:Q9JHH9]
exact_synonym: "Copz2" [UniProt:Q9JHH9, MGI:1929008]
exact_synonym: "nonclathrin coat protein zeta2-COP" [MGI:1929008]
exact_synonym: "Zeta-2 COP" [UniProt:Q9JHH9]
exact_synonym: "Zeta-2-coat protein" [UniProt:Q9JHH9]
exact_synonym: "zeta2-COP" [MGI:1929008]
xref_analog: UniProt:Q9JHH9
relationship: sequence_of IMR:0000665 ! zeta-2 COP

[Term]
id: IMR:0001997
name: GPI-PLD
exact_synonym: "glycosylphosphatidylinositol phospholipase D" []
exact_synonym: "phosphatidylinositol-glycan-specific phospholipase D" []
xref_analog: EC:3.1.4.50
is_a: IMR:0000281 ! phospholipase

[Term]
id: IMR:0001998
name: unclassified chemical
is_a: IMR:0000947 ! chemical

[Term]
id: IMR:0001999
name: Aspartate aminotransferase
exact_synonym: "Aspartate transaminase" []
exact_synonym: "Glutamic--aspartic transaminase" []
exact_synonym: "Glutamic--oxaloacetic transaminase" []
exact_synonym: "Transaminase A" []
xref_analog: EC:2.6.1.1
is_a: IMR:0000951 ! aminotransferase

[Term]
id: IMR:0002000
name: IVD_MOUSE
exact_synonym: "EC 1.3.99.10" [UniProt:Q9JHI5]
exact_synonym: "isovaleryl coenzyme A dehydrogenase" [MGI:1929242]
exact_synonym: "Isovaleryl-CoA dehydrogenase, mitochondrial" [UniProt:Q9JHI5]
exact_synonym: "Ivd" [MGI:1929242, UniProt:Q9JHI5]
exact_synonym: "IVD" [UniProt:Q9JHI5]
xref_analog: UniProt:Q9JHI5
relationship: sequence_of IMR:0010313 ! iso(3)valeryl-CoA dehydrogenase

[Term]
id: IMR:0002001
name: branched-chain aminotransferase
exact_synonym: "Branched-chain amino acid aminotransferase" []
exact_synonym: "Branched-chain-amino-acid transaminase" []
exact_synonym: "Transaminase B" []
xref_analog: EC:2.6.1.42
is_a: IMR:0000951 ! aminotransferase

[Term]
id: IMR:0002002
name: 6-phosphofructokinase
xref_analog: EC:2.7.1.11
is_a: IMR:0000956 ! phosphofructokinase

[Term]
id: IMR:0002003
name: ALAT2_HUMAN
exact_synonym: "AAT2" [UniProt:Q8TD30]
exact_synonym: "Alanine aminotransferase 2" [MIM:138210, UniProt:Q8TD30]
exact_synonym: "ALT2" [MIM:138210, HGNC:18062, EntrezGene:84706, UniProt:Q8TD30]
exact_synonym: "EC 2.6.1.2" [UniProt:Q8TD30]
exact_synonym: "Glutamate pyruvate transaminase 2" [MIM:138210, UniProt:Q8TD30]
exact_synonym: "GLUTAMATE-PYRUVATE TRANSAMINASE, MITOCHONDRIAL" [MIM:138210]
exact_synonym: "glutamic pyruvate transaminase (alanine aminotransferase) 2" [HGNC:18062, EntrezGene:84706]
exact_synonym: "Glutamic--alanine transaminase 2" [UniProt:Q8TD30]
exact_synonym: "Glutamic--pyruvic transaminase 2" [UniProt:Q8TD30]
exact_synonym: "GPT 2" [UniProt:Q8TD30]
exact_synonym: "GPT2" [MIM:138210, HGNC:18062, EntrezGene:84706, UniProt:Q8TD30]
xref_analog: UniProt:Q8TD30
relationship: sequence_of IMR:0010135 ! Alanine aminotransferase

[Term]
id: IMR:0002004
name: nitric oxide synthase
xref_analog: EC:1.14.13.39
xref_analog: GO:0004517
is_a: IMR:0000952 ! oxidoreductase

[Term]
id: IMR:0002005
name: NOS3_HUMAN
exact_synonym: "cNOS" [UniProt:P29474]
exact_synonym: "Constitutive NOS" [UniProt:P29474]
exact_synonym: "EC 1.14.13.39" [UniProt:P29474]
exact_synonym: "EC-NOS" [UniProt:P29474]
exact_synonym: "ECNOS" [EntrezGene:4846, HGNC:7876]
exact_synonym: "Endothelial NOS" [UniProt:P29474]
exact_synonym: "eNOS" [EntrezGene:4846, UniProt:P29474, HGNC:7876]
exact_synonym: "nitric oxide synthase 3 (endothelial cell)" [EntrezGene:4846, HGNC:7876]
exact_synonym: "Nitric oxide synthase, endothelial" [UniProt:P29474]
exact_synonym: "NOS type III" [UniProt:P29474]
exact_synonym: "NOS3" [EntrezGene:4846, UniProt:P29474, HGNC:7876]
exact_synonym: "NOSIII" [UniProt:P29474]
xref_analog: UniProt:P29474
relationship: sequence_of IMR:0002004 ! nitric oxide synthase

[Term]
id: IMR:0002006
name: P5CR3_HUMAN
exact_synonym: "EC 1.5.1.2" [UniProt:Q53H96]
exact_synonym: "FLJ13852" [EntrezGene:65263, HGNC:25846]
exact_synonym: "P5C reductase 3" [UniProt:Q53H96]
exact_synonym: "P5CR 3" [UniProt:Q53H96]
exact_synonym: "PYCRL" [UniProt:Q53H96, EntrezGene:65263, HGNC:25846]
exact_synonym: "Pyrroline-5-carboxylate reductase 3" [UniProt:Q53H96]
exact_synonym: "pyrroline-5-carboxylate reductase-like" [EntrezGene:65263, HGNC:25846]
exact_synonym: "Pyrroline-5-carboxylate reductase-like protein" [UniProt:Q53H96]
xref_analog: UniProt:Q53H96
relationship: sequence_of IMR:0010045 ! reductase

[Term]
id: IMR:0002007
name: ACSM1_HUMAN
exact_synonym: "ACSM1" [HGNC:18049, EntrezGene:116285, UniProt:Q08AH1]
exact_synonym: "Acyl-CoA synthetase medium-chain family member 1" [UniProt:Q08AH1]
exact_synonym: "acyl-CoA synthetase medium-chain family member 1" [HGNC:18049, EntrezGene:116285]
exact_synonym: "Acyl-coenzyme A synthetase ACSM1, mitochondrial" [UniProt:Q08AH1]
exact_synonym: "BUCS1" [EntrezGene:116285, UniProt:Q08AH1]
exact_synonym: "Butyrate--CoA ligase 1" [UniProt:Q08AH1]
exact_synonym: "Butyryl-coenzyme A synthetase 1" [UniProt:Q08AH1]
exact_synonym: "EC 6.2.1.2" [UniProt:Q08AH1]
exact_synonym: "LAE" [UniProt:Q08AH1]
exact_synonym: "Lipoate-activating enzyme" [UniProt:Q08AH1]
exact_synonym: "MACS1" [HGNC:18049, EntrezGene:116285, UniProt:Q08AH1]
exact_synonym: "MGC150532" [EntrezGene:116285]
exact_synonym: "Middle-chain acyl-CoA synthetase 1" [UniProt:Q08AH1]
xref_analog: UniProt:Q08AH1
relationship: sequence_of IMR:0010053 ! ligase

[Term]
id: IMR:0002008
name: GMPPA_HUMAN
exact_synonym: "EC 2.7.7.13" [UniProt:Q96IJ6]
exact_synonym: "GDP-mannose pyrophosphorylase A" [HGNC:22923, EntrezGene:29926, UniProt:Q96IJ6]
exact_synonym: "GMPPA" [HGNC:22923, EntrezGene:29926, UniProt:Q96IJ6]
exact_synonym: "GTP-mannose-1-phosphate guanylyltransferase alpha" [UniProt:Q96IJ6]
exact_synonym: "Mannose-1-phosphate guanyltransferase alpha" [UniProt:Q96IJ6]
xref_analog: UniProt:Q96IJ6
relationship: sequence_of IMR:0010050 ! transferase

[Term]
id: IMR:0002009
name: GMPPB_HUMAN
exact_synonym: "EC 2.7.7.13" [UniProt:Q9Y5P6]
exact_synonym: "GDP-mannose pyrophosphorylase B" [HGNC:22932, UniProt:Q9Y5P6, EntrezGene:29925]
exact_synonym: "GMPPB" [HGNC:22932, UniProt:Q9Y5P6, EntrezGene:29925]
exact_synonym: "GTP-mannose-1-phosphate guanylyltransferase beta" [UniProt:Q9Y5P6]
exact_synonym: "KIAA1851" [HGNC:22932, EntrezGene:29925]
exact_synonym: "Mannose-1-phosphate guanyltransferase beta" [UniProt:Q9Y5P6]
xref_analog: UniProt:Q9Y5P6
relationship: sequence_of IMR:0010050 ! transferase

[Term]
id: IMR:0002010
name: LALBA_HUMAN
exact_synonym: "Alpha-lactalbumin" [UniProt:P00709]
exact_synonym: "LACTALBUMIN, ALPHA" [MIM:149750]
exact_synonym: "lactalbumin, alpha-" [EntrezGene:3906, HGNC:6480]
exact_synonym: "Lactose synthase B protein" [UniProt:P00709]
exact_synonym: "LALBA" [UniProt:P00709, EntrezGene:3906, HGNC:6480, MIM:149750]
exact_synonym: "Lysozyme-like protein 7" [UniProt:P00709]
exact_synonym: "LYZL7" [UniProt:P00709, HGNC:6480]
exact_synonym: "MGC138521" [EntrezGene:3906]
exact_synonym: "MGC138523" [EntrezGene:3906]
xref_analog: UniProt:P00709
relationship: sequence_of IMR:0000429 ! enzyme regulator

[Term]
id: IMR:0002011
name: DHB12_HUMAN
exact_synonym: "17-@BETA-HSD XII" [MIM:609574]
exact_synonym: "17-@BETA-HYDROXYSTEROID DEHYDROGENASE XII" [MIM:609574]
exact_synonym: "17-beta-HSD 12" [UniProt:Q53GQ0]
exact_synonym: "17-beta-hydroxysteroid dehydrogenase 12" [UniProt:Q53GQ0]
exact_synonym: "3-@KETOACYL-CoA REDUCTASE" [MIM:609574]
exact_synonym: "3-ketoacyl-CoA reductase" [UniProt:Q53GQ0]
exact_synonym: "EC 1.1.1.62" [UniProt:Q53GQ0]
exact_synonym: "EC 1.3.1.-" [UniProt:Q53GQ0]
exact_synonym: "Estradiol 17-beta-dehydrogenase 12" [UniProt:Q53GQ0]
exact_synonym: "HSD17B12" [MIM:609574, HGNC:18646, UniProt:Q53GQ0, EntrezGene:51144]
exact_synonym: "hydroxysteroid (17-beta) dehydrogenase 12" [HGNC:18646, EntrezGene:51144]
exact_synonym: "KAR" [MIM:609574, HGNC:18646, UniProt:Q53GQ0, EntrezGene:51144]
exact_synonym: "SDR12C1" [HGNC:18646, EntrezGene:51144]
xref_analog: UniProt:Q53GQ0
relationship: sequence_of IMR:0000952 ! oxidoreductase

[Term]
id: IMR:0002012
name: AK1BA_HUMAN
exact_synonym: "AKR1B10" [MIM:604707, UniProt:O60218, EntrezGene:57016, HGNC:382]
exact_synonym: "AKR1B11" [UniProt:O60218, EntrezGene:57016]
exact_synonym: "AKR1B12" [EntrezGene:57016, HGNC:382]
exact_synonym: "Aldo-keto reductase family 1 member B10" [UniProt:O60218]
exact_synonym: "ALDO-KETO REDUCTASE FAMILY 1, MEMBER B10" [MIM:604707]
exact_synonym: "aldo-keto reductase family 1, member B10 (aldose reductase)" [EntrezGene:57016, HGNC:382]
exact_synonym: "Aldose reductase-like" [UniProt:O60218]
exact_synonym: "ALDOSE REDUCTASE-LIKE 1" [MIM:604707]
exact_synonym: "Aldose reductase-related protein" [UniProt:O60218]
exact_synonym: "ALDRLn" [EntrezGene:57016, HGNC:382]
exact_synonym: "ARL-1" [UniProt:O60218, EntrezGene:57016, HGNC:382]
exact_synonym: "ARL1" [MIM:604707, EntrezGene:57016, HGNC:382]
exact_synonym: "ARP" [UniProt:O60218]
exact_synonym: "EC 1.1.1.-" [UniProt:O60218]
exact_synonym: "hARP" [UniProt:O60218]
exact_synonym: "HIS" [EntrezGene:57016, HGNC:382]
exact_synonym: "HSI" [EntrezGene:57016, HGNC:382]
exact_synonym: "HSI REDUCTASE" [MIM:604707]
exact_synonym: "HUMAN SMALL INTESTINE REDUCTASE" [MIM:604707]
exact_synonym: "MGC14103" [EntrezGene:57016]
exact_synonym: "SI reductase" [UniProt:O60218]
exact_synonym: "Small intestine reductase" [UniProt:O60218]
xref_analog: UniProt:O60218
relationship: sequence_of IMR:0000952 ! oxidoreductase

[Term]
id: IMR:0002013
name: LDHD_HUMAN
exact_synonym: "D-LACTATE DEHYDROGENASE" [MIM:607490]
exact_synonym: "DLD" [UniProt:Q86WU2, EntrezGene:197257]
exact_synonym: "EC 1.1.2.4" [UniProt:Q86WU2]
exact_synonym: "Lactate dehydrogenase D" [UniProt:Q86WU2, MIM:607490]
exact_synonym: "lactate dehydrogenase D" [HGNC:19708, EntrezGene:197257]
exact_synonym: "LDHD" [UniProt:Q86WU2, HGNC:19708, MIM:607490, EntrezGene:197257]
exact_synonym: "MGC57726" [EntrezGene:197257]
exact_synonym: "Probable D-lactate dehydrogenase, mitochondrial" [UniProt:Q86WU2]
xref_analog: UniProt:Q86WU2
relationship: sequence_of IMR:0010047 ! dehydrogenase

[Term]
id: IMR:0002014
name: CNDP1_HUMAN
exact_synonym: "Beta-Ala-His dipeptidase" [UniProt:Q96KN2]
exact_synonym: "CARNOSINASE 1" [MIM:609064]
exact_synonym: "CARNOSINASE, SERUM" [MIM:609064]
exact_synonym: "Carnosine dipeptidase 1" [MIM:609064, UniProt:Q96KN2]
exact_synonym: "carnosine dipeptidase 1 (metallopeptidase M20 family)" [HGNC:20675, EntrezGene:84735]
exact_synonym: "CN1" [HGNC:20675, MIM:609064, EntrezGene:84735, UniProt:Q96KN2]
exact_synonym: "CNDP dipeptidase 1" [UniProt:Q96KN2]
exact_synonym: "CNDP1" [HGNC:20675, MIM:609064, EntrezGene:84735, UniProt:Q96KN2]
exact_synonym: "CPGL2" [HGNC:20675, EntrezGene:84735, UniProt:Q96KN2]
exact_synonym: "EC 3.4.13.20" [UniProt:Q96KN2]
exact_synonym: "Glutamate carboxypeptidase-like protein 2" [UniProt:Q96KN2]
exact_synonym: "HsT2308" [HGNC:20675, EntrezGene:84735]
exact_synonym: "MGC102737" [EntrezGene:84735]
exact_synonym: "MGC10825" [HGNC:20675, EntrezGene:84735]
exact_synonym: "MGC142072" [EntrezGene:84735]
exact_synonym: "Serum carnosinase" [UniProt:Q96KN2]
xref_analog: UniProt:Q96KN2
relationship: sequence_of IMR:0000304 ! protease

[Term]
id: IMR:0002015
name: SHIP2_HUMAN
exact_synonym: "EC 3.1.3.n1" [UniProt:O15357]
exact_synonym: "inositol polyphosphate phosphatase-like 1" [EntrezGene:3636, MIM:600829, HGNC:6080]
exact_synonym: "Inositol polyphosphate phosphatase-like protein 1" [UniProt:O15357]
exact_synonym: "INPPL-1" [UniProt:O15357]
exact_synonym: "INPPL1" [EntrezGene:3636, UniProt:O15357, MIM:600829, HGNC:6080]
exact_synonym: "Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2" [UniProt:O15357]
exact_synonym: "Protein 51C" [UniProt:O15357]
exact_synonym: "SH2 domain-containing inositol phosphatase 2" [UniProt:O15357]
exact_synonym: "SH2 domain-containing inositol-5'-phosphatase 2" [UniProt:O15357]
exact_synonym: "SH2-CONTAINING INOSITOL PHOSPHATASE 2" [MIM:600829]
exact_synonym: "SHIP-2" [UniProt:O15357]
exact_synonym: "SHIP2" [EntrezGene:3636, UniProt:O15357, MIM:600829, HGNC:6080]
xref_analog: UniProt:O15357
relationship: sequence_of IMR:0100365 ! inositol/phosphatidylinositol phosphatase

[Term]
id: IMR:0002016
name: PLCD3_HUMAN
exact_synonym: "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3" [UniProt:Q8N3E9]
exact_synonym: "EC 3.1.4.11" [UniProt:Q8N3E9]
exact_synonym: "KIAA1964" [UniProt:Q8N3E9]
exact_synonym: "MGC71172" [EntrezGene:113026]
exact_synonym: "Phosphoinositide phospholipase C-delta-3" [UniProt:Q8N3E9]
exact_synonym: "phospholipase C, delta 3" [EntrezGene:113026, HGNC:9061]
exact_synonym: "PHOSPHOLIPASE C, DELTA-3" [MIM:608795]
exact_synonym: "Phospholipase C-delta-3" [UniProt:Q8N3E9]
exact_synonym: "PLC-delta-3" [UniProt:Q8N3E9]
exact_synonym: "PLCD3" [MIM:608795, EntrezGene:113026, UniProt:Q8N3E9, HGNC:9061]
xref_analog: UniProt:Q8N3E9
relationship: sequence_of IMR:0000284 ! PLC

[Term]
id: IMR:0002017
name: PLCE1_HUMAN
exact_synonym: "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1" [UniProt:Q9P212]
exact_synonym: "EC 3.1.4.11" [UniProt:Q9P212]
exact_synonym: "FLJ23659" [EntrezGene:51196]
exact_synonym: "KIAA1516" [MIM:608414, UniProt:Q9P212, HGNC:17175, EntrezGene:51196]
exact_synonym: "MGC167842" [EntrezGene:51196]
exact_synonym: "NPHS3" [HGNC:17175, EntrezGene:51196]
exact_synonym: "Pancreas-enriched phospholipase C" [UniProt:Q9P212]
exact_synonym: "Phosphoinositide phospholipase C-epsilon-1" [UniProt:Q9P212]
exact_synonym: "phospholipase C, epsilon 1" [HGNC:17175, EntrezGene:51196]
exact_synonym: "PHOSPHOLIPASE C, EPSILON-1" [MIM:608414]
exact_synonym: "Phospholipase C-epsilon-1" [UniProt:Q9P212]
exact_synonym: "PLC-epsilon-1" [UniProt:Q9P212]
exact_synonym: "PLCE" [MIM:608414, UniProt:Q9P212, HGNC:17175, EntrezGene:51196]
exact_synonym: "PLCE1" [MIM:608414, UniProt:Q9P212, HGNC:17175, EntrezGene:51196]
exact_synonym: "PPLC" [UniProt:Q9P212, EntrezGene:51196]
xref_analog: UniProt:Q9P212
relationship: sequence_of IMR:0000284 ! PLC

[Term]
id: IMR:0002018
name: PLCD4_HUMAN
exact_synonym: "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4" [UniProt:Q9BRC7]
exact_synonym: "EC 3.1.4.11" [UniProt:Q9BRC7]
exact_synonym: "hPLCD4" [UniProt:Q9BRC7]
exact_synonym: "MGC12837" [EntrezGene:84812]
exact_synonym: "Phosphoinositide phospholipase C-delta-4" [UniProt:Q9BRC7]
exact_synonym: "phospholipase C, delta 4" [HGNC:9062, EntrezGene:84812]
exact_synonym: "PHOSPHOLIPASE C, DELTA-4" [MIM:605939]
exact_synonym: "Phospholipase C-delta-4" [UniProt:Q9BRC7]
exact_synonym: "PLC-delta-4" [UniProt:Q9BRC7]
exact_synonym: "PLCD4" [MIM:605939, HGNC:9062, EntrezGene:84812, UniProt:Q9BRC7]
xref_analog: UniProt:Q9BRC7
relationship: sequence_of IMR:0000284 ! PLC

[Term]
id: IMR:0002019
name: PLCZ1_HUMAN
exact_synonym: "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1" [UniProt:Q86YW0]
exact_synonym: "EC 3.1.4.11" [UniProt:Q86YW0]
exact_synonym: "MGC149685" [EntrezGene:89869]
exact_synonym: "NYD-SP27" [EntrezGene:89869, HGNC:19218]
exact_synonym: "Phosphoinositide phospholipase C-zeta-1" [UniProt:Q86YW0]
exact_synonym: "phospholipase C, zeta 1" [EntrezGene:89869, HGNC:19218]
exact_synonym: "PHOSPHOLIPASE C, ZETA-1" [MIM:608075]
exact_synonym: "Phospholipase C-zeta-1" [UniProt:Q86YW0]
exact_synonym: "PLC-zeta-1" [UniProt:Q86YW0]
exact_synonym: "PLCZ1" [EntrezGene:89869, UniProt:Q86YW0, MIM:608075, HGNC:19218]
exact_synonym: "PLCzeta" [EntrezGene:89869, HGNC:19218]
exact_synonym: "Testis-development protein NYD-SP27" [UniProt:Q86YW0]
xref_analog: UniProt:Q86YW0
relationship: sequence_of IMR:0000284 ! PLC

[Term]
id: IMR:0002020
name: PI42C_HUMAN
exact_synonym: "EC 2.7.1.149" [UniProt:Q8TBX8]
exact_synonym: "FLJ22055" [HGNC:23786, EntrezGene:79837]
exact_synonym: "Phosphatidylinositol-5-phosphate 4-kinase type II gamma" [UniProt:Q8TBX8]
exact_synonym: "Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma" [UniProt:Q8TBX8]
exact_synonym: "phosphatidylinositol-5-phosphate 4-kinase, type II, gamma" [HGNC:23786, EntrezGene:79837]
exact_synonym: "PI(5)P 4-kinase type II gamma" [UniProt:Q8TBX8]
exact_synonym: "PIP4K2C" [HGNC:23786, UniProt:Q8TBX8, EntrezGene:79837]
exact_synonym: "PIP4KII-gamma" [UniProt:Q8TBX8]
exact_synonym: "PIP5K2C" [UniProt:Q8TBX8, EntrezGene:79837]
xref_analog: UniProt:Q8TBX8
relationship: sequence_of IMR:0000268 ! PI5k

[Term]
id: IMR:0002021
name: PI3R5_HUMAN
exact_synonym: "F730038I15Rik" [EntrezGene:23533]
exact_synonym: "FOAP-2" [EntrezGene:23533]
exact_synonym: "p101" [EntrezGene:23533, MIM:611317, HGNC:30035]
exact_synonym: "p101-PI3K" [UniProt:Q8WYR1]
exact_synonym: "P101-PI3K" [EntrezGene:23533, HGNC:30035]
exact_synonym: "PHOSPHATIDYLINOSITOL 3-KINASE, REGULATORY SUBUNIT 5" [MIM:611317]
exact_synonym: "Phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit" [UniProt:Q8WYR1]
exact_synonym: "Phosphoinositide 3-kinase regulatory subunit 5" [UniProt:Q8WYR1]
exact_synonym: "phosphoinositide-3-kinase, regulatory subunit 5" [EntrezGene:23533, HGNC:30035]
exact_synonym: "PI3-kinase p101 subunit" [UniProt:Q8WYR1]
exact_synonym: "PI3-kinase regulatory subunit 5" [UniProt:Q8WYR1]
exact_synonym: "PIK3R5" [UniProt:Q8WYR1, EntrezGene:23533, MIM:611317, HGNC:30035]
exact_synonym: "Protein FOAP-2" [UniProt:Q8WYR1]
exact_synonym: "PtdIns-3-kinase p101" [UniProt:Q8WYR1]
exact_synonym: "PtdIns-3-kinase regulatory subunit" [UniProt:Q8WYR1]
xref_analog: UniProt:Q8WYR1
relationship: sequence_of IMR:0000429 ! enzyme regulator

[Term]
id: IMR:0002022
name: ADPPT_HUMAN
exact_synonym: "4'-phosphopantetheinyl transferase" [UniProt:Q9NRN7]
exact_synonym: "AASD-PPT" [EntrezGene:60496, UniProt:Q9NRN7, HGNC:14235]
exact_synonym: "AASDHPPT" [EntrezGene:60496, UniProt:Q9NRN7, MIM:607756, HGNC:14235]
exact_synonym: "AASDPPT" [MIM:607756]
exact_synonym: "ALPHA-AMINOADIPATE SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE" [MIM:607756]
exact_synonym: "Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase" [UniProt:Q9NRN7]
exact_synonym: "aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase" [EntrezGene:60496, HGNC:14235]
exact_synonym: "CGI-80" [MIM:607756, HGNC:14235]
exact_synonym: "DKFZP566E2346" [MIM:607756]
exact_synonym: "DKFZp566E2346" [EntrezGene:60496]
exact_synonym: "EC 2.7.8.-" [UniProt:Q9NRN7]
exact_synonym: "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase" [UniProt:Q9NRN7]
exact_synonym: "LYS2" [EntrezGene:60496]
exact_synonym: "LYS5" [EntrezGene:60496, HGNC:14235]
exact_synonym: "LYS5 ortholog" [UniProt:Q9NRN7]
exact_synonym: "LYS5, S. CEREVISIAE, HOMOLOG OF" [MIM:607756]
xref_analog: UniProt:Q9NRN7
relationship: sequence_of IMR:0010050 ! transferase

[Term]
id: IMR:0002023
name: MAT2B_HUMAN
exact_synonym: "DTDP-4-keto-6-deoxy-D-glucose 4-reductase" [UniProt:Q9NZL9]
exact_synonym: "MAT II beta" [UniProt:Q9NZL9]
exact_synonym: "MAT-II" [EntrezGene:27430]
exact_synonym: "MAT2B" [HGNC:6905, MIM:605527, UniProt:Q9NZL9, EntrezGene:27430]
exact_synonym: "MATIIbeta" [HGNC:6905, EntrezGene:27430]
exact_synonym: "Methionine adenosyltransferase 2 subunit beta" [UniProt:Q9NZL9]
exact_synonym: "Methionine adenosyltransferase II beta" [UniProt:Q9NZL9]
exact_synonym: "methionine adenosyltransferase II, beta" [HGNC:6905, MIM:605527, EntrezGene:27430]
exact_synonym: "MGC12237" [EntrezGene:27430]
exact_synonym: "Nbla02999" [EntrezGene:27430]
exact_synonym: "SDR23E1" [HGNC:6905, EntrezGene:27430]
exact_synonym: "TGR" [UniProt:Q9NZL9, EntrezGene:27430]
xref_analog: UniProt:Q9NZL9
relationship: sequence_of IMR:0002592 ! MAT II beta subunit

[Term]
id: IMR:0002024
name: MTMR1_HUMAN
exact_synonym: "EC 3.1.3.-" [UniProt:Q13613]
exact_synonym: "MTMR1" [UniProt:Q13613, HGNC:7449, MIM:300171, EntrezGene:8776]
exact_synonym: "myotubularin related protein 1" [HGNC:7449, EntrezGene:8776]
exact_synonym: "Myotubularin-related protein 1" [UniProt:Q13613, MIM:300171]
xref_analog: UniProt:Q13613
relationship: sequence_of IMR:0010044 ! hydrolase

[Term]
id: IMR:0002025
name: MTMR2_HUMAN
exact_synonym: "CMT4B" [EntrezGene:8898]
exact_synonym: "CMT4B1" [EntrezGene:8898]
exact_synonym: "EC 3.1.3.-" [UniProt:Q13614]
exact_synonym: "KIAA1073" [MIM:603557, UniProt:Q13614, EntrezGene:8898, HGNC:7450]
exact_synonym: "MTMR2" [MIM:603557, UniProt:Q13614, EntrezGene:8898, HGNC:7450]
exact_synonym: "myotubularin related protein 2" [EntrezGene:8898, HGNC:7450]
exact_synonym: "Myotubularin-related protein 2" [MIM:603557, UniProt:Q13614]
xref_analog: UniProt:Q13614
relationship: sequence_of IMR:0010044 ! hydrolase

[Term]
id: IMR:0002026
name: MTMR6_HUMAN
exact_synonym: "EC 3.1.3.-" [UniProt:Q9Y217]
exact_synonym: "MTMR6" [EntrezGene:9107, MIM:603561, UniProt:Q9Y217, HGNC:7453]
exact_synonym: "myotubularin related protein 6" [EntrezGene:9107, HGNC:7453]
exact_synonym: "Myotubularin-related protein 6" [MIM:603561, UniProt:Q9Y217]
xref_analog: UniProt:Q9Y217
relationship: sequence_of IMR:0010044 ! hydrolase

[Term]
id: IMR:0002027
name: NADE_HUMAN
exact_synonym: "EC 6.3.5.1" [UniProt:Q6IA69]
exact_synonym: "FLJ10631" [HGNC:29832, EntrezGene:55191]
exact_synonym: "FLJ36703" [EntrezGene:55191]
exact_synonym: "FLJ40627" [EntrezGene:55191]
exact_synonym: "Glutamine-dependent NAD(+) synthetase" [UniProt:Q6IA69]
exact_synonym: "NAD synthetase 1" [HGNC:29832, EntrezGene:55191, MIM:608285]
exact_synonym: "NAD(+) synthase [glutamine-hydrolyzing]" [UniProt:Q6IA69]
exact_synonym: "NAD(+) synthetase" [UniProt:Q6IA69]
exact_synonym: "NADSYN1" [HGNC:29832, UniProt:Q6IA69, EntrezGene:55191, MIM:608285]
xref_analog: UniProt:Q6IA69
relationship: sequence_of IMR:0010053 ! ligase

[Term]
id: IMR:0002028
name: TKTL2_HUMAN
exact_synonym: "DKFZP434L1717" [HGNC:25313]
exact_synonym: "DKFZp434L1717" [EntrezGene:84076]
exact_synonym: "EC 2.2.1.1" [UniProt:Q9H0I9]
exact_synonym: "FLJ32975" [EntrezGene:84076, HGNC:25313]
exact_synonym: "TKTL2" [UniProt:Q9H0I9, EntrezGene:84076, HGNC:25313]
exact_synonym: "transketolase-like 2" [EntrezGene:84076, HGNC:25313]
exact_synonym: "Transketolase-like protein 2" [UniProt:Q9H0I9]
xref_analog: UniProt:Q9H0I9
relationship: sequence_of IMR:0010050 ! transferase

[Term]
id: IMR:0002029
name: ACD11_HUMAN
exact_synonym: "ACAD-11" [EntrezGene:84129, UniProt:Q709F0]
exact_synonym: "ACAD11" [EntrezGene:84129, UniProt:Q709F0, HGNC:30211]
exact_synonym: "Acyl-CoA dehydrogenase family member 11" [UniProt:Q709F0]
exact_synonym: "acyl-CoA dehydrogenase family, member 11" [EntrezGene:84129, HGNC:30211]
exact_synonym: "EC 1.3.99.-" [UniProt:Q709F0]
exact_synonym: "FLJ12592" [EntrezGene:84129, HGNC:30211]
exact_synonym: "MGC150619" [EntrezGene:84129]
xref_analog: UniProt:Q709F0
relationship: sequence_of IMR:0000999 ! acyl-CoA dehydrogenase

[Term]
id: IMR:0002030
name: GGTL2_HUMAN
exact_synonym: "Gamma-glutamyltransferase light chain 2" [UniProt:Q14390]
exact_synonym: "gamma-glutamyltransferase light chain 2" [EntrezGene:91227, HGNC:18596]
exact_synonym: "GAMMA-GLUTAMYLTRANSFERASE, LIGHT CHAIN 2" [MIM:612339]
exact_synonym: "Gamma-glutamyltransferase-like protein 4" [UniProt:Q14390]
exact_synonym: "GGT, TYPE III" [MIM:612339]
exact_synonym: "GGTL4" [EntrezGene:91227, UniProt:Q14390, MIM:612339]
exact_synonym: "GGTLC2" [EntrezGene:91227, UniProt:Q14390, MIM:612339, HGNC:18596]
exact_synonym: "MGC96916" [EntrezGene:91227]
xref_analog: UniProt:Q14390
relationship: sequence_of IMR:0000955 ! acyltransferase

[Term]
id: IMR:0002031
name: NDK5_HUMAN
exact_synonym: "Inhibitor of p53-induced apoptosis-beta" [UniProt:P56597]
exact_synonym: "IPIA-beta" [UniProt:P56597]
exact_synonym: "NDK-H 5" [UniProt:P56597]
exact_synonym: "NDP kinase homolog 5" [UniProt:P56597]
exact_synonym: "nm23-H5" [HGNC:7853, UniProt:P56597]
exact_synonym: "NM23-H5" [EntrezGene:8382]
exact_synonym: "NM23H5" [EntrezGene:8382, MIM:603575]
exact_synonym: "NME5" [EntrezGene:8382, HGNC:7853, MIM:603575, UniProt:P56597]
exact_synonym: "non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)" [EntrezGene:8382, HGNC:7853]
exact_synonym: "NONMETASTATIC CELLS 5, PROTEIN EXPRESSED IN" [MIM:603575]
exact_synonym: "NONMETASTATIC PROTEIN 23, HOMOLOG 5" [MIM:603575]
exact_synonym: "Nucleoside diphosphate kinase homolog 5" [UniProt:P56597]
exact_synonym: "RSPH23" [EntrezGene:8382, HGNC:7853]
exact_synonym: "Testis-specific nm23 homolog" [UniProt:P56597]
xref_analog: UniProt:P56597
relationship: sequence_of IMR:0002044 ! NDK5

[Term]
id: IMR:0002032
name: ENTP2_HUMAN
exact_synonym: "CD39 antigen-like 1" [UniProt:Q9Y5L3]
exact_synonym: "CD39-LIKE 1" [MIM:602012]
exact_synonym: "CD39L1" [EntrezGene:954, UniProt:Q9Y5L3, MIM:602012]
exact_synonym: "EC 3.6.1.-" [UniProt:Q9Y5L3]
exact_synonym: "Ecto-ATP diphosphohydrolase 2" [UniProt:Q9Y5L3]
exact_synonym: "Ecto-ATPase 2" [UniProt:Q9Y5L3]
exact_synonym: "Ecto-ATPDase 2" [UniProt:Q9Y5L3]
exact_synonym: "Ectonucleoside triphosphate diphosphohydrolase 2" [UniProt:Q9Y5L3, MIM:602012]
exact_synonym: "ectonucleoside triphosphate diphosphohydrolase 2" [HGNC:3364, EntrezGene:954]
exact_synonym: "ENTPD2" [HGNC:3364, EntrezGene:954, UniProt:Q9Y5L3, MIM:602012]
exact_synonym: "NTPDase 2" [UniProt:Q9Y5L3]
exact_synonym: "NTPDase-2" [HGNC:3364, EntrezGene:954]
xref_analog: UniProt:Q9Y5L3
relationship: sequence_of IMR:0002652 ! CD39/NTPDase family

[Term]
id: IMR:0002033
name: ADCYA_HUMAN
exact_synonym: "ADCY10" [UniProt:Q96PN6, EntrezGene:55811, HGNC:21285]
exact_synonym: "adenylate cyclase 10 (soluble)" [EntrezGene:55811, HGNC:21285]
exact_synonym: "Adenylate cyclase homolog" [UniProt:Q96PN6]
exact_synonym: "Adenylate cyclase type 10" [UniProt:Q96PN6]
exact_synonym: "ADENYLYL CYCLASE, SOLUBLE" [MIM:605205]
exact_synonym: "AH-related protein" [UniProt:Q96PN6]
exact_synonym: "EC 4.6.1.1" [UniProt:Q96PN6]
exact_synonym: "Germ cell soluble adenylyl cyclase" [UniProt:Q96PN6]
exact_synonym: "HCA2" [EntrezGene:55811, HGNC:21285]
exact_synonym: "hsAC" [UniProt:Q96PN6]
exact_synonym: "RP1-313L4.2" [EntrezGene:55811, HGNC:21285]
exact_synonym: "sAC" [UniProt:Q96PN6, MIM:605205]
exact_synonym: "SAC" [UniProt:Q96PN6, EntrezGene:55811, HGNC:21285]
exact_synonym: "SACI" [EntrezGene:55811, HGNC:21285]
exact_synonym: "Sacy" [EntrezGene:55811, HGNC:21285]
exact_synonym: "SOLUBLE ADENYLYL CYCLASE" [MIM:605205]
exact_synonym: "Testicular soluble adenylyl cyclase" [UniProt:Q96PN6]
xref_analog: UniProt:Q96PN6
relationship: sequence_of IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0002034
name: PYRG2_HUMAN
exact_synonym: "CTP synthase 2" [UniProt:Q9NRF8, MIM:300380]
exact_synonym: "CTP synthase II" [EntrezGene:56474, HGNC:2520]
exact_synonym: "CTP synthetase 2" [UniProt:Q9NRF8, MIM:300380]
exact_synonym: "CTPS2" [UniProt:Q9NRF8, EntrezGene:56474, HGNC:2520, MIM:300380]
exact_synonym: "CYTIDINE 5-PRIME TRIPHOSPHATE SYNTHETASE 2" [MIM:300380]
exact_synonym: "DKFZp686C17207" [EntrezGene:56474]
exact_synonym: "EC 6.3.4.2" [UniProt:Q9NRF8]
exact_synonym: "FLJ43358" [EntrezGene:56474]
exact_synonym: "MGC32997" [EntrezGene:56474]
exact_synonym: "UTP--ammonia ligase 2" [UniProt:Q9NRF8]
xref_analog: UniProt:Q9NRF8
relationship: sequence_of IMR:0010442 ! CTP synthase

[Term]
id: IMR:0002035
name: HAGHL_HUMAN
exact_synonym: "EC 3.1.2.-" [UniProt:Q6PII5]
exact_synonym: "HAGHL" [UniProt:Q6PII5, EntrezGene:84264, HGNC:14177]
exact_synonym: "hydroxyacylglutathione hydrolase-like" [EntrezGene:84264, HGNC:14177]
exact_synonym: "Hydroxyacylglutathione hydrolase-like protein" [UniProt:Q6PII5]
exact_synonym: "MGC2605" [EntrezGene:84264, HGNC:14177]
xref_analog: UniProt:Q6PII5
relationship: sequence_of IMR:0001043 ! thiolester hydrolases

[Term]
id: IMR:0002036
name: NFX1_HUMAN
exact_synonym: "EC 6.3.2.-" [UniProt:Q12986]
exact_synonym: "MGC20369" [HGNC:7803]
exact_synonym: "NFX1" [HGNC:7803, UniProt:Q12986, MIM:603255]
exact_synonym: "NFX2" [HGNC:7803, UniProt:Q12986]
exact_synonym: "Nuclear transcription factor, X box-binding protein 1" [UniProt:Q12986]
exact_synonym: "NUCLEAR TRANSCRIPTION FACTOR, X BOX-BINDING, 1" [MIM:603255]
exact_synonym: "nuclear transcription factor, X-box binding 1" [HGNC:7803]
exact_synonym: "Transcriptional repressor NF-X1" [UniProt:Q12986]
xref_analog: UniProt:Q12986
relationship: sequence_of IMR:0010053 ! ligase

[Term]
id: IMR:0002037
name: RNF25_HUMAN
exact_synonym: "AO7" [HGNC:14662, EntrezGene:64320]
exact_synonym: "E3 ubiquitin-protein ligase RNF25" [UniProt:Q96BH1]
exact_synonym: "EC 6.3.2.-" [UniProt:Q96BH1]
exact_synonym: "FLJ13906" [HGNC:14662, EntrezGene:64320]
exact_synonym: "RING finger protein 25" [UniProt:Q96BH1]
exact_synonym: "ring finger protein 25" [HGNC:14662, EntrezGene:64320]
exact_synonym: "RNF25" [UniProt:Q96BH1, HGNC:14662, EntrezGene:64320]
xref_analog: UniProt:Q96BH1
relationship: sequence_of IMR:0010053 ! ligase

[Term]
id: IMR:0002038
name: UBE3A_HUMAN
exact_synonym: "ANCR" [EntrezGene:7337, HGNC:12496]
exact_synonym: "AS" [EntrezGene:7337, HGNC:12496]
exact_synonym: "E6-AP" [EntrezGene:7337, HGNC:12496]
exact_synonym: "E6AP" [UniProt:Q05086, MIM:601623]
exact_synonym: "E6AP ubiquitin-protein ligase" [UniProt:Q05086]
exact_synonym: "EC 6.3.2.-" [UniProt:Q05086]
exact_synonym: "EPVE6AP" [EntrezGene:7337, UniProt:Q05086]
exact_synonym: "FLJ26981" [EntrezGene:7337, HGNC:12496]
exact_synonym: "HPVE6A" [EntrezGene:7337, UniProt:Q05086]
exact_synonym: "Human papillomavirus E6-associated protein" [UniProt:Q05086, MIM:601623]
exact_synonym: "Oncogenic protein-associated protein E6-AP" [UniProt:Q05086]
exact_synonym: "Renal carcinoma antigen NY-REN-54" [UniProt:Q05086]
exact_synonym: "UBE3A" [EntrezGene:7337, UniProt:Q05086, MIM:601623, HGNC:12496]
exact_synonym: "ubiquitin protein ligase E3A" [EntrezGene:7337, HGNC:12496]
exact_synonym: "Ubiquitin-protein ligase E3A" [UniProt:Q05086, MIM:601623]
xref_analog: UniProt:Q05086
relationship: sequence_of IMR:0010053 ! ligase

[Term]
id: IMR:0002039
name: AFMID_HUMAN
exact_synonym: "AFMID" [UniProt:Q63HM1, EntrezGene:125061, HGNC:20910]
exact_synonym: "arylformamidase" [EntrezGene:125061, HGNC:20910]
exact_synonym: "DKFZp686F03259" [EntrezGene:125061, HGNC:20910]
exact_synonym: "EC 3.5.1.9" [UniProt:Q63HM1]
exact_synonym: "KF" [UniProt:Q63HM1, EntrezGene:125061, HGNC:20910]
exact_synonym: "Kynurenine formamidase" [UniProt:Q63HM1]
exact_synonym: "MGC167063" [EntrezGene:125061]
exact_synonym: "Probable arylformamidase" [UniProt:Q63HM1]
xref_analog: UniProt:Q63HM1
relationship: sequence_of IMR:0010044 ! hydrolase

[Term]
id: IMR:0002040
name: HOT_HUMAN
exact_synonym: "ADH8" [EntrezGene:137872, MIM:611083]
exact_synonym: "ADHFe1" [UniProt:Q8IWW8, MIM:611083, HGNC:16354]
exact_synonym: "ADHFE1" [UniProt:Q8IWW8, EntrezGene:137872, HGNC:16354]
exact_synonym: "ALCOHOL DEHYDROGENASE 8" [MIM:611083]
exact_synonym: "Alcohol dehydrogenase iron-containing protein 1" [UniProt:Q8IWW8]
exact_synonym: "alcohol dehydrogenase, iron containing, 1" [EntrezGene:137872, HGNC:16354]
exact_synonym: "ALCOHOL DEHYDROGENASE, IRON-CONTAINING, 1" [MIM:611083]
exact_synonym: "EC 1.1.99.24" [UniProt:Q8IWW8]
exact_synonym: "Fe-containing alcohol dehydrogenase" [UniProt:Q8IWW8]
exact_synonym: "FLJ32430" [EntrezGene:137872, HGNC:16354]
exact_synonym: "HOT" [UniProt:Q8IWW8, EntrezGene:137872, MIM:611083]
exact_synonym: "HYDROXYACID-OXOACID TRANSHYDROGENASE" [MIM:611083]
exact_synonym: "Hydroxyacid-oxoacid transhydrogenase, mitochondrial" [UniProt:Q8IWW8]
exact_synonym: "MGC48605" [EntrezGene:137872]
xref_analog: UniProt:Q8IWW8
relationship: sequence_of IMR:0001001 ! alcohol dehydrogenase

[Term]
id: IMR:0002041
name: N4-Acetyl-amino-butanoic acid
xref_analog: KEGG:C02946
is_a: IMR:0001998 ! unclassified chemical

[Term]
id: IMR:0002042
name: 3-Carboxy-1-hydroxypropyl-ThPP
xref_analog: KEGG:C05381
is_a: IMR:0001998 ! unclassified chemical

[Term]
id: IMR:0002043
name: (R)-S-Lactoyl-glutathione
xref_analog: KEGG:C03451
is_a: IMR:0001998 ! unclassified chemical

[Term]
id: IMR:0002044
name: NDK5
is_a: IMR:0010012 ! nucleoside diphosphate kinase

[Term]
id: IMR:0002045
name: NDK5_MOUSE
exact_synonym: "NDK-H 5" [UniProt:Q99MH5]
exact_synonym: "NDP kinase homolog 5" [UniProt:Q99MH5]
exact_synonym: "nm23-M5" [UniProt:Q99MH5]
exact_synonym: "Nm23-M5" [MGI:1922783]
exact_synonym: "Nme5" [MGI:1922783, UniProt:Q99MH5]
exact_synonym: "non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)" [MGI:1922783]
exact_synonym: "Nucleoside diphosphate kinase homolog 5" [UniProt:Q99MH5]
xref_analog: UniProt:Q99MH5
relationship: sequence_of IMR:0002044 ! NDK5

[Term]
id: IMR:0002046
name: NDK6
is_a: IMR:0010012 ! nucleoside diphosphate kinase

[Term]
id: IMR:0002047
name: NDK6_MOUSE
exact_synonym: "EC 2.7.4.6" [UniProt:O88425]
exact_synonym: "NDK 6" [UniProt:O88425]
exact_synonym: "NDP kinase 6" [UniProt:O88425]
exact_synonym: "nm23-M6" [MGI:1861676, UniProt:O88425]
exact_synonym: "nm23/nucleoside diphosphate kinase 6" [MGI:1861676]
exact_synonym: "Nme6" [MGI:1861676, UniProt:O88425]
exact_synonym: "non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)" [MGI:1861676]
exact_synonym: "Nucleoside diphosphate kinase 6" [UniProt:O88425]
xref_analog: UniProt:O88425
relationship: sequence_of IMR:0002046 ! NDK6

[Term]
id: IMR:0002048
name: NDK6_RAT
exact_synonym: "EC 2.7.4.6" [UniProt:O88426]
exact_synonym: "NDK 6" [UniProt:O88426]
exact_synonym: "NDP kinase 6" [UniProt:O88426]
exact_synonym: "nm23-R6" [UniProt:O88426]
exact_synonym: "Nme6" [RGD:61896, UniProt:O88426]
exact_synonym: "non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)" [RGD:61896]
exact_synonym: "Nucleoside diphosphate kinase 6" [UniProt:O88426]
xref_analog: UniProt:O88426
relationship: sequence_of IMR:0002046 ! NDK6

[Term]
id: IMR:0002049
name: NDK7
is_a: IMR:0010012 ! nucleoside diphosphate kinase

[Term]
id: IMR:0002050
name: NDK7_MOUSE
exact_synonym: "EC 2.7.4.6" [UniProt:Q9QXL8]
exact_synonym: "NDK 7" [UniProt:Q9QXL8]
exact_synonym: "NDP kinase 7" [UniProt:Q9QXL8]
exact_synonym: "nm23-M7" [UniProt:Q9QXL8]
exact_synonym: "Nm23-M7" [MGI:2449121]
exact_synonym: "Nme7" [MGI:2449121, UniProt:Q9QXL8]
exact_synonym: "non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)" [MGI:2449121]
exact_synonym: "Nucleoside diphosphate kinase 7" [UniProt:Q9QXL8]
exact_synonym: "nucleoside-diphosphate kinase" [MGI:2449121]
xref_analog: UniProt:Q9QXL8
relationship: sequence_of IMR:0002049 ! NDK7

[Term]
id: IMR:0002051
name: NDK7_RAT
exact_synonym: "EC 2.7.4.6" [UniProt:Q9QXL7]
exact_synonym: "NDK 7" [UniProt:Q9QXL7]
exact_synonym: "NDP kinase 7" [UniProt:Q9QXL7]
exact_synonym: "nm23-R7" [UniProt:Q9QXL7]
exact_synonym: "Nme7" [UniProt:Q9QXL7, RGD:619880]
exact_synonym: "non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)" [RGD:619880]
exact_synonym: "Nucleoside diphosphate kinase 7" [UniProt:Q9QXL7]
xref_analog: UniProt:Q9QXL7
relationship: sequence_of IMR:0002049 ! NDK7

[Term]
id: IMR:0002052
name: P79925_XENLA
exact_synonym: "FGF-8" [UniProt:P79925]
exact_synonym: "Fibroblast growth factor 8" [UniProt:P79925]
xref_analog: UniProt:P79925
relationship: sequence_of IMR:0100558 ! FGF-8

[Term]
id: IMR:0002053
name: FGFR1_XENLA
exact_synonym: "EC 2.7.10.1" [UniProt:P22182]
exact_synonym: "FGFR-1" [UniProt:P22182]
exact_synonym: "fgfr1" [UniProt:P22182]
exact_synonym: "fgfra2" [UniProt:P22182]
exact_synonym: "Fibroblast growth factor receptor 1" [UniProt:P22182]
xref_analog: UniProt:P22182
relationship: sequence_of IMR:0002055 ! FGFR1

[Term]
id: IMR:0002054
name: FGFR2_XENLA
exact_synonym: "EC 2.7.10.1" [UniProt:Q03364]
exact_synonym: "FGFR-2" [UniProt:Q03364]
exact_synonym: "fgfr2" [UniProt:Q03364]
exact_synonym: "Fibroblast growth factor receptor 2" [UniProt:Q03364]
xref_analog: UniProt:Q03364
relationship: sequence_of IMR:0002056 ! FGFR2

[Term]
id: IMR:0002055
name: FGFR1
exact_synonym: "fibroblast growth factor receptor 1" []
is_a: IMR:0000080 ! FGFR

[Term]
id: IMR:0002056
name: FGFR2
exact_synonym: "fibroblast growth factor receptor 2" []
is_a: IMR:0000080 ! FGFR

[Term]
id: IMR:0002057
name: FGFR3
exact_synonym: "fibroblast growth factor receptor 3" []
is_a: IMR:0000080 ! FGFR

[Term]
id: IMR:0002058
name: FGFR4
exact_synonym: "fibroblast growth factor receptor 4" []
is_a: IMR:0000080 ! FGFR

[Term]
id: IMR:0002059
name: Q90ZF5_XENLA
exact_synonym: "FRS2" [UniProt:Q90ZF5]
exact_synonym: "xFRS2" [UniProt:Q90ZF5]
xref_analog: UniProt:Q90ZF5
relationship: sequence_of IMR:0001836 ! FRS2

[Term]
id: IMR:0002060
name: GRB2_HUMAN
exact_synonym: "ABUNDANT SRC HOMOLOGY" [MIM:108355]
exact_synonym: "Adapter protein GRB2" [UniProt:P62993]
exact_synonym: "ASH" [UniProt:P62993]
exact_synonym: "ASH PROTEIN" [MIM:108355]
exact_synonym: "GRB2" [HGNC:4566, MIM:108355, UniProt:P62993]
exact_synonym: "Growth factor receptor-bound protein 2" [MIM:108355, UniProt:P62993]
exact_synonym: "growth factor receptor-bound protein 2" [HGNC:4566]
exact_synonym: "NCKAP2" [HGNC:4566]
exact_synonym: "Protein Ash" [UniProt:P62993]
exact_synonym: "SH2/SH3 adapter GRB2" [UniProt:P62993]
xref_analog: UniProt:P62993
relationship: sequence_of IMR:0000340 ! Grb2

[Term]
id: IMR:0002061
name: GRB2A_XENLA
exact_synonym: "Adapter protein GRB2-A" [UniProt:P87379]
exact_synonym: "grb2-a" [UniProt:P87379]
exact_synonym: "Growth factor receptor-bound protein 2-A" [UniProt:P87379]
exact_synonym: "SH2/SH3 adapter GRB2-A" [UniProt:P87379]
xref_analog: UniProt:P87379
relationship: sequence_of IMR:0000340 ! Grb2

[Term]
id: IMR:0002062
name: GRB2B_XENLA
exact_synonym: "Adapter protein GRB2-B" [UniProt:Q6GPJ9]
exact_synonym: "grb2-b" [UniProt:Q6GPJ9]
exact_synonym: "Growth factor receptor-bound protein 2-B" [UniProt:Q6GPJ9]
exact_synonym: "SH2/SH3 adapter GRB2-B" [UniProt:Q6GPJ9]
xref_analog: UniProt:Q6GPJ9
relationship: sequence_of IMR:0000340 ! Grb2

[Term]
id: IMR:0002063
name: Sos1
is_a: IMR:0000435 ! Sos

[Term]
id: IMR:0002064
name: Sos2
is_a: IMR:0000435 ! Sos

[Term]
id: IMR:0002065
name: RASK_XENLA
exact_synonym: "GTPase KRas" [UniProt:Q05147]
exact_synonym: "K-ras" [UniProt:Q05147]
exact_synonym: "Ki-Ras" [UniProt:Q05147]
exact_synonym: "kras" [UniProt:Q05147]
xref_analog: UniProt:Q05147
relationship: sequence_of IMR:0000291 ! K-Ras

[Term]
id: IMR:0002066
name: RASN_XENLA
exact_synonym: "GTPase NRas" [UniProt:Q91806]
exact_synonym: "nras" [UniProt:Q91806]
exact_synonym: "Transforming protein N-Ras" [UniProt:Q91806]
xref_analog: UniProt:Q91806
relationship: sequence_of IMR:0000696 ! N-Ras

[Term]
id: IMR:0002067
name: RAN_XENLA
exact_synonym: "GTP-binding nuclear protein Ran" [UniProt:P52301]
exact_synonym: "GTPase Ran" [UniProt:P52301]
exact_synonym: "ran" [UniProt:P52301]
exact_synonym: "Ras-like protein TC4" [UniProt:P52301]
exact_synonym: "Ras-related nuclear protein" [UniProt:P52301]
xref_analog: UniProt:P52301
relationship: sequence_of IMR:0000300 ! Ran

[Term]
id: IMR:0002068
name: Q8UUZ4_XENLA
exact_synonym: "hras" [UniProt:Q8UUZ4]
exact_synonym: "Small G-protein H-Ras" [UniProt:Q8UUZ4]
xref_analog: UniProt:Q8UUZ4
relationship: sequence_of IMR:0000695 ! H-Ras

[Term]
id: IMR:0002069
name: Q767H6_XENLA
exact_synonym: "ARAF" [UniProt:Q767H6]
exact_synonym: "Serine/threonine protein kinase ARAF" [UniProt:Q767H6]
xref_analog: UniProt:Q767H6
relationship: sequence_of IMR:0000674 ! A-Raf

[Term]
id: IMR:0002070
name: Q767H5_XENLA
exact_synonym: "braf" [UniProt:Q767H5]
exact_synonym: "BRAF" [UniProt:Q767H5]
exact_synonym: "Serine/threonine protein kinase BRAF" [UniProt:Q767H5]
xref_analog: UniProt:Q767H5
relationship: sequence_of IMR:0000675 ! B-Raf

[Term]
id: IMR:0002071
name: RAF1_XENLA
exact_synonym: "C-RAF" [UniProt:P09560]
exact_synonym: "EC 2.7.11.1" [UniProt:P09560]
exact_synonym: "raf" [UniProt:P09560]
exact_synonym: "RAF proto-oncogene serine/threonine-protein kinase" [UniProt:P09560]
exact_synonym: "raf1" [UniProt:P09560]
xref_analog: UniProt:P09560
relationship: sequence_of IMR:0100355 ! Raf-1

[Term]
id: IMR:0002072
name: Sprouty
def: "Sprouty (Spry) proteins represent a major class of ligand-inducible inhibitors of RTK-dependent signaling pathways. Sprouty was first identified in Drosophila. Based on sequence homology to Drosophila Spry, orthologs were identified in vertebrate." [PubMed:16337795]
exact_synonym: "Spry" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0002073
name: SPY_DROME
exact_synonym: "Calcineurin suppressor, chromosome 3, group 3" [FlyBase:FBgn0014388]
exact_synonym: "CG1921" [FlyBase:FBgn0014388]
exact_synonym: "CS3-3" [FlyBase:FBgn0014388]
exact_synonym: "dSprouty" [FlyBase:FBgn0014388]
exact_synonym: "dSPRY" [FlyBase:FBgn0014388]
exact_synonym: "Protein sprouty" [UniProt:O44783]
exact_synonym: "Sprouty" [FlyBase:FBgn0014388]
exact_synonym: "sprouty" [FlyBase:FBgn0014388]
exact_synonym: "Spry" [UniProt:O44783, FlyBase:FBgn0014388]
exact_synonym: "spry" [FlyBase:FBgn0014388]
exact_synonym: "Sry" [FlyBase:FBgn0014388]
exact_synonym: "sty" [UniProt:O44783, FlyBase:FBgn0014388]
exact_synonym: "Sty" [FlyBase:FBgn0014388]
xref_analog: UniProt:O44783
relationship: sequence_of IMR:0002072 ! Sprouty

[Term]
id: IMR:0002074
name: SPY1_HUMAN
exact_synonym: "hSPRY1" [EntrezGene:10252, HGNC:11269]
exact_synonym: "Protein sprouty homolog 1" [UniProt:O43609]
exact_synonym: "sprouty homolog 1, antagonist of FGF signaling (Drosophila)" [EntrezGene:10252, HGNC:11269]
exact_synonym: "SPROUTY, DROSOPHILA, HOMOLOG OF, 1" [MIM:602465]
exact_synonym: "Spry-1" [UniProt:O43609]
exact_synonym: "SPRY1" [MIM:602465, EntrezGene:10252, HGNC:11269, UniProt:O43609]
xref_analog: UniProt:O43609
relationship: sequence_of IMR:0002081 ! Sprouty1

[Term]
id: IMR:0002075
name: SPY1_MOUSE
exact_synonym: "Protein sprouty homolog 1" [UniProt:Q9QXV9]
exact_synonym: "sprouty 1" [MGI:1345139]
exact_synonym: "sprouty homolog 1 (Drosophila)" [MGI:1345139]
exact_synonym: "sprouty1" [MGI:1345139]
exact_synonym: "Spry-1" [UniProt:Q9QXV9]
exact_synonym: "Spry1" [UniProt:Q9QXV9, MGI:1345139]
xref_analog: UniProt:Q9QXV9
relationship: sequence_of IMR:0002081 ! Sprouty1

[Term]
id: IMR:0002076
name: SPY2_HUMAN
exact_synonym: "hSPRY2" [EntrezGene:10253, HGNC:11270]
exact_synonym: "MGC23039" [EntrezGene:10253]
exact_synonym: "Protein sprouty homolog 2" [UniProt:O43597]
exact_synonym: "sprouty homolog 2 (Drosophila)" [EntrezGene:10253, HGNC:11270]
exact_synonym: "SPROUTY, DROSOPHILA, HOMOLOG OF, 2" [MIM:602466]
exact_synonym: "Spry-2" [UniProt:O43597]
exact_synonym: "SPRY2" [EntrezGene:10253, MIM:602466, UniProt:O43597, HGNC:11270]
xref_analog: UniProt:O43597
relationship: sequence_of IMR:0002082 ! Sprouty2

[Term]
id: IMR:0002077
name: SPY2_MOUSE
exact_synonym: "Protein sprouty homolog 2" [UniProt:Q9QXV8]
exact_synonym: "sprouty homolog 2 (Drosophila)" [MGI:1345138]
exact_synonym: "sprouty2" [MGI:1345138]
exact_synonym: "Spry-2" [UniProt:Q9QXV8]
exact_synonym: "Spry2" [UniProt:Q9QXV8, MGI:1345138]
xref_analog: UniProt:Q9QXV8
relationship: sequence_of IMR:0002082 ! Sprouty2

[Term]
id: IMR:0002078
name: SPY3_HUMAN
exact_synonym: "HSPRY3" [HGNC:11271, EntrezGene:10251]
exact_synonym: "Protein sprouty homolog 3" [UniProt:O43610]
exact_synonym: "sprouty homolog 3 (Drosophila)" [HGNC:11271, EntrezGene:10251]
exact_synonym: "SPROUTY, DROSOPHILA, HOMOLOG OF, 3" [MIM:300531]
exact_synonym: "Spry-3" [UniProt:O43610]
exact_synonym: "SPRY3" [UniProt:O43610, MIM:300531, HGNC:11271, EntrezGene:10251]
xref_analog: UniProt:O43610
relationship: sequence_of IMR:0002083 ! Sprouty3

[Term]
id: IMR:0002079
name: SPY4_HUMAN
exact_synonym: "Protein sprouty homolog 4" [UniProt:Q9C004]
exact_synonym: "sprouty homolog 4 (Drosophila)" [HGNC:15533, EntrezGene:81848]
exact_synonym: "SPROUTY, DROSOPHILA, HOMOLOG OF, 4" [MIM:607984]
exact_synonym: "Spry-4" [UniProt:Q9C004]
exact_synonym: "SPRY4" [MIM:607984, HGNC:15533, UniProt:Q9C004, EntrezGene:81848]
xref_analog: UniProt:Q9C004
relationship: sequence_of IMR:0002084 ! Sprouty4

[Term]
id: IMR:0002080
name: SPY4_MOUSE
exact_synonym: "Protein sprouty homolog 4" [UniProt:Q9WTP2]
exact_synonym: "sprouty homolog 4 (Drosophila)" [MGI:1345144]
exact_synonym: "sprouty4" [MGI:1345144]
exact_synonym: "Spry-4" [UniProt:Q9WTP2]
exact_synonym: "Spry4" [MGI:1345144, UniProt:Q9WTP2]
xref_analog: UniProt:Q9WTP2
relationship: sequence_of IMR:0002084 ! Sprouty4

[Term]
id: IMR:0002081
name: Sprouty1
exact_synonym: "Spry1" []
is_a: IMR:0002072 ! Sprouty

[Term]
id: IMR:0002082
name: Sprouty2
exact_synonym: "Spry2" []
is_a: IMR:0002072 ! Sprouty

[Term]
id: IMR:0002083
name: Sprouty3
exact_synonym: "Spry3" []
is_a: IMR:0002072 ! Sprouty

[Term]
id: IMR:0002084
name: Sprouty4
exact_synonym: "Spry4" []
is_a: IMR:0002072 ! Sprouty

[Term]
id: IMR:0002085
name: Q90ZT6_XENLA
exact_synonym: "LOC398313" [UniProt:Q90ZT6]
exact_synonym: "LOC398313 protein" [UniProt:Q90ZT6]
exact_synonym: "Sprouty 2" [UniProt:Q90ZT6]
exact_synonym: "Sprouty2" [UniProt:Q90ZT6]
exact_synonym: "spry2" [UniProt:Q90ZT6]
xref_analog: UniProt:Q90ZT6
relationship: sequence_of IMR:0002082 ! Sprouty2

[Term]
id: IMR:0002086
name: Sef
exact_synonym: "similar expression to fgf genes" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0002087
name: I17RD_DANRE
exact_synonym: "cb208" [UniProt:Q8QHJ9]
exact_synonym: "IL-17 receptor D" [UniProt:Q8QHJ9]
exact_synonym: "IL-17RD" [UniProt:Q8QHJ9]
exact_synonym: "il17rd" [UniProt:Q8QHJ9]
exact_synonym: "Interleukin-17 receptor D" [UniProt:Q8QHJ9]
exact_synonym: "Sef" [UniProt:Q8QHJ9]
exact_synonym: "sef" [UniProt:Q8QHJ9]
exact_synonym: "Similar expression to FGF genes protein" [UniProt:Q8QHJ9]
xref_analog: UniProt:Q8QHJ9
relationship: sequence_of IMR:0002086 ! Sef

[Term]
id: IMR:0002088
name: I17RD_HUMAN
exact_synonym: "DKFZp434N1928" [EntrezGene:54756]
exact_synonym: "FLJ35755" [EntrezGene:54756, HGNC:17616]
exact_synonym: "hSef" [UniProt:Q8NFM7]
exact_synonym: "IL-17 receptor D" [UniProt:Q8NFM7]
exact_synonym: "IL-17RD" [UniProt:Q8NFM7, EntrezGene:54756, HGNC:17616]
exact_synonym: "IL17RD" [UniProt:Q8NFM7, EntrezGene:54756, MIM:606807, HGNC:17616]
exact_synonym: "IL17Rhom" [UniProt:Q8NFM7]
exact_synonym: "IL17RLM" [UniProt:Q8NFM7, EntrezGene:54756, HGNC:17616]
exact_synonym: "interleukin 17 receptor D" [EntrezGene:54756, MIM:606807, HGNC:17616]
exact_synonym: "Interleukin-17 receptor D" [UniProt:Q8NFM7]
exact_synonym: "Interleukin-17 receptor-like protein" [UniProt:Q8NFM7]
exact_synonym: "MGC133309" [EntrezGene:54756]
exact_synonym: "SEF" [UniProt:Q8NFM7, EntrezGene:54756, MIM:606807, HGNC:17616]
exact_synonym: "Sef homolog" [UniProt:Q8NFM7]
exact_synonym: "SEF, ZEBRAFISH, HOMOLOG OF" [MIM:606807]
xref_analog: UniProt:Q8NFM7
relationship: sequence_of IMR:0002086 ! Sef

[Term]
id: IMR:0002089
name: I17RD_MOUSE
exact_synonym: "IL-17 receptor D" [UniProt:Q8JZL1]
exact_synonym: "IL-17RD" [UniProt:Q8JZL1]
exact_synonym: "Il17rd" [MGI:2159727, UniProt:Q8JZL1]
exact_synonym: "Il17rlm" [UniProt:Q8JZL1]
exact_synonym: "interleukin 17 receptor D" [MGI:2159727]
exact_synonym: "Interleukin-17 receptor D" [UniProt:Q8JZL1]
exact_synonym: "Interleukin-17 receptor-like protein" [UniProt:Q8JZL1]
exact_synonym: "mSef" [UniProt:Q8JZL1]
exact_synonym: "Sef" [MGI:2159727, UniProt:Q8JZL1]
exact_synonym: "Sef homolog" [UniProt:Q8JZL1]
exact_synonym: "Sef-S" [MGI:2159727]
xref_analog: UniProt:Q8JZL1
relationship: sequence_of IMR:0002086 ! Sef

[Term]
id: IMR:0002090
name: immunoglobulin
def: "Antibody molecule (immunoglobulin) consists of four polypeptides chains, two identical light (L) chains and two identical heavy (H) chains.\nIn mammals, there are five classes of antibodies, IgA, IgD, IgE, IgG, and IgM." [ISBN:0815340729]
exact_synonym: "antibody" []
exact_synonym: "Ig" []
xref_analog: GO:0003823
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0002091
name: IgA
exact_synonym: "immunoglobulin A" []
is_a: IMR:0002090 ! immunoglobulin

[Term]
id: IMR:0002092
name: IgD
exact_synonym: "immunoglobulin D" []
is_a: IMR:0002090 ! immunoglobulin
is_a: IMR:0002948 ! mIgM/mIgD

[Term]
id: IMR:0002093
name: IgE
exact_synonym: "immunoglobulin E" []
is_a: IMR:0002090 ! immunoglobulin

[Term]
id: IMR:0002094
name: IgG
exact_synonym: "immunoglobulin G" []
is_a: IMR:0002090 ! immunoglobulin

[Term]
id: IMR:0002095
name: heavy chain
exact_synonym: "H chain" []
exact_synonym: "Ig heavychain" []
exact_synonym: "immunoglobulin heavy chain" []
relationship: part_of IMR:0002090 ! immunoglobulin

[Term]
id: IMR:0002096
name: light chain
def: "Higher vertebrates have two types of light chains, kappa and lamda, which seem to be functionally indistinguishable. Either type of light chain may be associated with any of the heavy chains." [ISBN:0815340729]
exact_synonym: "Ig light chain" []
exact_synonym: "immunoglobulin light chain" []
exact_synonym: "L chain" []
relationship: part_of IMR:0000154 ! lgM
relationship: part_of IMR:0002090 ! immunoglobulin
relationship: part_of IMR:0002091 ! IgA
relationship: part_of IMR:0002092 ! IgD
relationship: part_of IMR:0002093 ! IgE
relationship: part_of IMR:0002094 ! IgG
relationship: part_of IMR:0002948 ! mIgM/mIgD

[Term]
id: IMR:0002097
name: pre-BCR
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0002098
name: alpha heavy chain
is_a: IMR:0002095 ! heavy chain
relationship: part_of IMR:0002091 ! IgA

[Term]
id: IMR:0002099
name: delta heavy chain
is_a: IMR:0002095 ! heavy chain
is_a: IMR:0002949 ! mu heavy chain/delta heavy chain
relationship: part_of IMR:0002092 ! IgD

[Term]
id: IMR:0002100
name: epsilon heavy chain
exact_synonym: "IgE heavy chain" []
exact_synonym: "immunoglobulin epsilon heavy chain" []
is_a: IMR:0002095 ! heavy chain
relationship: part_of IMR:0002093 ! IgE

[Term]
id: IMR:0002101
name: gamma heavy chain
exact_synonym: "IgG heavy chain" []
exact_synonym: "immunoglobulin gamma heavy chain" []
is_a: IMR:0002095 ! heavy chain
relationship: part_of IMR:0002094 ! IgG

[Term]
id: IMR:0002102
name: kappa light chain
is_a: IMR:0002096 ! light chain

[Term]
id: IMR:0002103
name: lambda light chain
is_a: IMR:0002096 ! light chain

[Term]
id: IMR:0002104
name: mu heavy chain
exact_synonym: "IgM heavy chain" []
exact_synonym: "immunoglobulin mu heavy chain" []
is_a: IMR:0002095 ! heavy chain
is_a: IMR:0002949 ! mu heavy chain/delta heavy chain
relationship: part_of IMR:0000154 ! lgM
relationship: part_of IMR:0002097 ! pre-BCR

[Term]
id: IMR:0002105
name: IGHA1_HUMAN
exact_synonym: "FLJ14473" [EntrezGene:3493]
exact_synonym: "FLJ35065" [EntrezGene:3493]
exact_synonym: "FLJ35500" [EntrezGene:3493]
exact_synonym: "FLJ36402" [EntrezGene:3493]
exact_synonym: "FLJ39698" [EntrezGene:3493]
exact_synonym: "FLJ40001" [EntrezGene:3493]
exact_synonym: "FLJ41548" [EntrezGene:3493]
exact_synonym: "FLJ41552" [EntrezGene:3493]
exact_synonym: "FLJ41789" [EntrezGene:3493]
exact_synonym: "FLJ43248" [EntrezGene:3493]
exact_synonym: "FLJ43594" [EntrezGene:3493]
exact_synonym: "FLJ44293" [EntrezGene:3493]
exact_synonym: "FLJ46028" [EntrezGene:3493]
exact_synonym: "FLJ46621" [EntrezGene:3493]
exact_synonym: "FLJ46724" [EntrezGene:3493]
exact_synonym: "FLJ46811" [EntrezGene:3493]
exact_synonym: "FLJ46824" [EntrezGene:3493]
exact_synonym: "FLJ90170" [EntrezGene:3493]
exact_synonym: "Ig alpha-1 chain C region" [UniProt:P01876]
exact_synonym: "IgA CONSTANT HEAVY CHAIN 1" [MIM:146900]
exact_synonym: "IgA1" [EntrezGene:3493]
exact_synonym: "IGHA1" [HGNC:5478, EntrezGene:3493, UniProt:P01876, MIM:146900]
exact_synonym: "IMMUNOGLOBULIN Am1" [MIM:146900]
exact_synonym: "immunoglobulin heavy constant alpha 1" [HGNC:5478, EntrezGene:3493]
exact_synonym: "MGC102857" [EntrezGene:3493]
xref_analog: UniProt:P01876
relationship: sequence_of IMR:0002098 ! alpha heavy chain

[Term]
id: IMR:0002106
name: IGHA2_HUMAN
exact_synonym: "Ig alpha-2 chain C region" [UniProt:P01877]
exact_synonym: "IgA CONSTANT HEAVY CHAIN 2" [MIM:147000]
exact_synonym: "IGHA2" [MIM:147000, EntrezGene:3494, HGNC:5479, UniProt:P01877]
exact_synonym: "IMMUNOGLOBULIN Am2" [MIM:147000]
exact_synonym: "immunoglobulin heavy constant alpha 2 (A2m marker)" [EntrezGene:3494, HGNC:5479]
xref_analog: UniProt:P01877
relationship: sequence_of IMR:0002098 ! alpha heavy chain

[Term]
id: IMR:0002107
name: IGHA_MOUSE
exact_synonym: "Ig alpha chain C region" [UniProt:P01878]
xref_analog: UniProt:P01878
relationship: sequence_of IMR:0002098 ! alpha heavy chain

[Term]
id: IMR:0002108
name: IGHG1_HUMAN
exact_synonym: "Ig gamma-1 chain C region" [UniProt:P01857]
exact_synonym: "IgG HEAVY CHAIN LOCUS" [MIM:147100]
exact_synonym: "IGHG1" [HGNC:5525, UniProt:P01857, EntrezGene:3500, MIM:147100]
exact_synonym: "IMMUNOGLOBULIN Gm1" [MIM:147100]
exact_synonym: "immunoglobulin heavy constant gamma 1 (G1m marker)" [HGNC:5525, EntrezGene:3500]
xref_analog: UniProt:P01857
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002109
name: IGHG1_MOUSE
exact_synonym: "Ig gamma-1 chain C region secreted form" [UniProt:P01868]
exact_synonym: "IgG1" [MGI:96446]
exact_synonym: "Igh-4" [MGI:96446, UniProt:P01868]
exact_synonym: "Ighg1" [MGI:96446, UniProt:P01868]
exact_synonym: "immunoglobulin heavy constant gamma 1 (G1m marker)" [MGI:96446]
xref_analog: UniProt:P01868
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002110
name: IGHG2_HUMAN
exact_synonym: "DKFZp686I04196" [EntrezGene:3501]
exact_synonym: "Ig gamma-2 chain C region" [UniProt:P01859]
exact_synonym: "IGHG2" [UniProt:P01859, MIM:147110, HGNC:5526, EntrezGene:3501]
exact_synonym: "IMMUNOGLOBULIN Gm2" [MIM:147110]
exact_synonym: "immunoglobulin heavy constant gamma 2 (G2m marker)" [HGNC:5526, EntrezGene:3501]
xref_analog: UniProt:P01859
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002111
name: IGHG3_HUMAN
exact_synonym: "DKFZp686H11213" [EntrezGene:3502]
exact_synonym: "FLJ39988" [EntrezGene:3502]
exact_synonym: "FLJ40036" [EntrezGene:3502]
exact_synonym: "FLJ40253" [EntrezGene:3502]
exact_synonym: "FLJ40587" [EntrezGene:3502]
exact_synonym: "FLJ40789" [EntrezGene:3502]
exact_synonym: "FLJ40834" [EntrezGene:3502]
exact_synonym: "HDC" [UniProt:P01860]
exact_synonym: "Heavy chain disease protein" [UniProt:P01860]
exact_synonym: "Ig gamma-3 chain C region" [UniProt:P01860]
exact_synonym: "IgG3" [EntrezGene:3502]
exact_synonym: "IGHG3" [UniProt:P01860, EntrezGene:3502, HGNC:5527, MIM:147120]
exact_synonym: "IMMUNOGLOBULIN Gm3" [MIM:147120]
exact_synonym: "immunoglobulin heavy constant gamma 3 (G3m marker)" [EntrezGene:3502, HGNC:5527]
exact_synonym: "MGC45809" [EntrezGene:3502]
xref_analog: UniProt:P01860
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002112
name: IGHG4_HUMAN
exact_synonym: "Ig gamma-4 chain C region" [UniProt:P01861]
exact_synonym: "IGHG4" [MIM:147130, HGNC:5528, EntrezGene:3503, UniProt:P01861]
exact_synonym: "IMMUNOGLOBULIN Gm4" [MIM:147130]
exact_synonym: "immunoglobulin heavy constant gamma 4 (G4m marker)" [HGNC:5528, EntrezGene:3503]
exact_synonym: "MGC117419" [EntrezGene:3503]
xref_analog: UniProt:P01861
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002113
name: IGHD_HUMAN
exact_synonym: "FLJ00382" [EntrezGene:3495, HGNC:5480]
exact_synonym: "FLJ46727" [EntrezGene:3495, HGNC:5480]
exact_synonym: "Ig delta chain C region" [UniProt:P01880]
exact_synonym: "IGHD" [EntrezGene:3495, UniProt:P01880, MIM:147170, HGNC:5480]
exact_synonym: "immunoglobulin heavy constant delta" [EntrezGene:3495, HGNC:5480]
exact_synonym: "IMMUNOGLOBULIN: HEAVY DELTA CHAIN" [MIM:147170]
exact_synonym: "MGC29633" [EntrezGene:3495, HGNC:5480]
xref_analog: UniProt:P01880
relationship: sequence_of IMR:0002099 ! delta heavy chain

[Term]
id: IMR:0002114
name: IGHE_HUMAN
exact_synonym: "Ig epsilon chain C region" [UniProt:P01854]
exact_synonym: "IgE" [EntrezGene:3497, MIM:147180]
exact_synonym: "IGHE" [UniProt:P01854, EntrezGene:3497, MIM:147180, HGNC:5522]
exact_synonym: "IMMUNOGLOBULIN EPSILON" [MIM:147180]
exact_synonym: "immunoglobulin heavy constant epsilon" [EntrezGene:3497, HGNC:5522]
exact_synonym: "IMMUNOGLOBULIN: HEAVY EPSILON CHAIN" [MIM:147180]
xref_analog: UniProt:P01854
relationship: sequence_of IMR:0002100 ! epsilon heavy chain

[Term]
id: IMR:0002116
name: IGHM_HUMAN
alt_id: IMR:0002115
comment: This entry describes 2 isoforms produced by alternative splicing. Membrane bound form and secreted form.
exact_synonym: "AGM1" [EntrezGene:3507]
exact_synonym: "DKFZp686I15196" [EntrezGene:3507]
exact_synonym: "DKFZp686I15212" [EntrezGene:3507]
exact_synonym: "FLJ00385" [EntrezGene:3507]
exact_synonym: "Ig mu chain C region" [UniProt:P01871]
exact_synonym: "IGHM" [EntrezGene:3507, MIM:147020, HGNC:5541, UniProt:P01871]
exact_synonym: "IgM HEAVY CHAIN CONSTANT REGION" [MIM:147020]
exact_synonym: "IMMUNOGLOBULIN HEAVY CHAIN CONSTANT REGION MU" [MIM:147020]
exact_synonym: "IMMUNOGLOBULIN HEAVY CHAIN MU CONSTANT REGION" [MIM:147020]
exact_synonym: "immunoglobulin heavy constant mu" [EntrezGene:3507, HGNC:5541]
exact_synonym: "MGC104996" [EntrezGene:3507]
exact_synonym: "MGC52291" [EntrezGene:3507]
exact_synonym: "MU" [EntrezGene:3507]
exact_synonym: "VH" [EntrezGene:3507]
xref_analog: UniProt:P01871
relationship: sequence_of IMR:0002104 ! mu heavy chain

[Term]
id: IMR:0002117
name: IGHD_MOUSE
exact_synonym: "Ig delta chain C region secreted form" [UniProt:P01881]
xref_analog: UniProt:P01881
relationship: sequence_of IMR:0002099 ! delta heavy chain

[Term]
id: IMR:0002118
name: IGHDM_MOUSE
exact_synonym: "Ig delta chain C region membrane-bound form" [UniProt:P01882]
xref_analog: UniProt:P01882
relationship: sequence_of IMR:0002099 ! delta heavy chain

[Term]
id: IMR:0002119
name: IGHD_RAT
exact_synonym: "Ig delta chain C region" [UniProt:P01883]
xref_analog: UniProt:P01883
relationship: sequence_of IMR:0002099 ! delta heavy chain

[Term]
id: IMR:0002120
name: aldosterone
exact_synonym: "11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al" []
exact_synonym: "Aldosterone" []
xref_analog: CHEBI:27584
xref_analog: KEGG:C01780
is_a: IMR:0100037 ! mineralocorticoid

[Term]
id: IMR:0002121
name: biogenic amine
def: "A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology." [MeSH:D001679]
xref_analog: CHEBI:22879
xref_analog: MeSH:D001679
is_a: IMR:0001693 ! amin

[Term]
id: IMR:0002122
name: CALC_HUMAN
exact_synonym: "CALC1" [EntrezGene:796, MIM:114130, UniProt:P01258]
exact_synonym: "CALCA" [EntrezGene:796, MIM:114130, HGNC:1437, UniProt:P01258]
exact_synonym: "Calcitonin" [MIM:114130, UniProt:P01258]
exact_synonym: "Calcitonin carboxyl-terminal peptide" [UniProt:P01258]
exact_synonym: "calcitonin-related polypeptide alpha" [EntrezGene:796, HGNC:1437]
exact_synonym: "CALCITONIN/CALCITONIN-RELATED POLYPEPTIDE, ALPHA" [MIM:114130]
exact_synonym: "CCP" [UniProt:P01258]
exact_synonym: "CGRP" [EntrezGene:796]
exact_synonym: "CGRP-I" [EntrezGene:796]
exact_synonym: "CGRP1" [EntrezGene:796]
exact_synonym: "CT" [EntrezGene:796, MIM:114130]
exact_synonym: "Katacalcin" [UniProt:P01258]
exact_synonym: "KC" [EntrezGene:796]
exact_synonym: "MGC126648" [EntrezGene:796]
exact_synonym: "PDN-21" [UniProt:P01258]
xref_analog: UniProt:P01258
relationship: sequence_of IMR:0100045 ! calcitonin

[Term]
id: IMR:0002123
name: CALC_MOUSE
exact_synonym: "alpha CGRP" [MGI:2151253]
exact_synonym: "CA" [MGI:2151253]
exact_synonym: "Calc" [MGI:2151253, UniProt:P70160]
exact_synonym: "Calca" [MGI:2151253, UniProt:P70160]
exact_synonym: "Calcitonin" [UniProt:P70160]
exact_synonym: "calcitonin/calcitonin-related polypeptide, alpha" [MGI:2151253]
exact_synonym: "Cgrp" [MGI:2151253]
exact_synonym: "Ct" [MGI:2151253]
exact_synonym: "CT" [MGI:2151253]
exact_synonym: "Ctn" [MGI:2151253]
xref_analog: UniProt:P70160
relationship: sequence_of IMR:0100045 ! calcitonin

[Term]
id: IMR:0002124
name: CALC_RAT
exact_synonym: "Calc" [UniProt:P01257]
exact_synonym: "Calca" [UniProt:P01257, RGD:2254]
exact_synonym: "Calcitonin" [UniProt:P01257]
exact_synonym: "calcitonin-related polypeptide alpha" [RGD:2254]
xref_analog: UniProt:P01257
relationship: sequence_of IMR:0100045 ! calcitonin

[Term]
id: IMR:0002125
name: monosaccharide
xref_analog: CHEBI:35381
xref_analog: MeSH:D009005
is_a: IMR:0001657 ! carbohydrate

[Term]
id: IMR:0002126
name: methionyl-lysyl-bradykinin
is_a: IMR:0100165 ! kinin

[Term]
id: IMR:0002127
name: Ski/SnoN family
def: "Ski/SnoN family of oncoproteins act as transcriptional co-repressors in TGF-beta signaling through interaction with Smads. Orthologues of Ski and SnoN have now been identified in mouse, Xenopus, chicken, zebra fish and tilapia." [PubMed:11312113, PubMed:15108807]
xref_analog: IPR:003380
is_a: IMR:0000427 ! transcription co-repressor

[Term]
id: IMR:0002128
name: Ski
exact_synonym: "c-Ski" []
is_a: IMR:0002127 ! Ski/SnoN family

[Term]
id: IMR:0002129
name: SnoN
exact_synonym: "Sno" []
is_a: IMR:0002127 ! Ski/SnoN family

[Term]
id: IMR:0002130
name: SKI_HUMAN
exact_synonym: "ONCOGENE SK, CHICKEN VIRAL" [MIM:164780]
exact_synonym: "Proto-oncogene c-Ski" [UniProt:P12755]
exact_synonym: "SK ONCOGENE" [MIM:164780]
exact_synonym: "SKI" [EntrezGene:6497, MIM:164780, HGNC:10896, UniProt:P12755]
exact_synonym: "Ski oncogene" [UniProt:P12755]
exact_synonym: "SKV" [EntrezGene:6497]
exact_synonym: "V-SKI AVIAN SARCOMA VIRAL ONCOGENE HOMOLOG" [MIM:164780]
exact_synonym: "v-ski sarcoma viral oncogene homolog (avian)" [EntrezGene:6497, HGNC:10896]
xref_analog: UniProt:P12755
relationship: sequence_of IMR:0002128 ! Ski

[Term]
id: IMR:0002131
name: SKI_MOUSE
exact_synonym: "Proto-oncogene c-Ski" [UniProt:Q60698]
exact_synonym: "Ski" [MGI:98310, UniProt:Q60698]
exact_synonym: "Ski oncogene" [UniProt:Q60698]
exact_synonym: "ski sarcoma viral oncogene homolog (avian)" [MGI:98310]
xref_analog: UniProt:Q60698
relationship: sequence_of IMR:0002128 ! Ski

[Term]
id: IMR:0002132
name: SKI_XENLA
exact_synonym: "Proto-oncogene c-Ski" [UniProt:Q02225]
exact_synonym: "ski" [UniProt:Q02225]
exact_synonym: "Ski oncogene" [UniProt:Q02225]
xref_analog: UniProt:Q02225
relationship: sequence_of IMR:0002128 ! Ski

[Term]
id: IMR:0002133
name: SKI_CHICK
exact_synonym: "Proto-oncogene c-Ski" [UniProt:P49140]
exact_synonym: "SKI" [UniProt:P49140]
exact_synonym: "Ski oncogene" [UniProt:P49140]
xref_analog: UniProt:P49140
relationship: sequence_of IMR:0002128 ! Ski

[Term]
id: IMR:0002134
name: SKIL_HUMAN
exact_synonym: "ONCOGENE SNO" [MIM:165340]
exact_synonym: "SKI-LIKE" [MIM:165340]
exact_synonym: "SKI-like oncogene" [EntrezGene:6498, HGNC:10897]
exact_synonym: "Ski-like protein" [UniProt:P12757]
exact_synonym: "Ski-related oncogene" [UniProt:P12757]
exact_synonym: "Ski-related protein" [UniProt:P12757]
exact_synonym: "SKIL" [EntrezGene:6498, HGNC:10897, UniProt:P12757, MIM:165340]
exact_synonym: "SNO" [EntrezGene:6498, HGNC:10897, UniProt:P12757, MIM:165340]
exact_synonym: "SnoA" [EntrezGene:6498, HGNC:10897]
exact_synonym: "SnoI" [EntrezGene:6498]
exact_synonym: "SnoN" [EntrezGene:6498, HGNC:10897]
xref_analog: UniProt:P12757
relationship: sequence_of IMR:0002129 ! SnoN

[Term]
id: IMR:0002135
name: SKIL_MOUSE
exact_synonym: "SKI-like" [MGI:106203]
exact_synonym: "Ski-like protein" [UniProt:Q60665]
exact_synonym: "Ski-related oncogene" [UniProt:Q60665]
exact_synonym: "Ski-related protein" [UniProt:Q60665]
exact_synonym: "Skil" [MGI:106203, UniProt:Q60665]
exact_synonym: "Skir" [MGI:106203, UniProt:Q60665]
exact_synonym: "Sno" [UniProt:Q60665]
exact_synonym: "sno-dE3" [MGI:106203]
exact_synonym: "SnoN" [MGI:106203]
exact_synonym: "SnoN2" [MGI:106203]
xref_analog: UniProt:Q60665
relationship: sequence_of IMR:0002129 ! SnoN

[Term]
id: IMR:0002136
name: Bam32
def: "Bam32, also known as DAPP1 or PHISH, is an adaptor protein consisting of an N-terminal SH2 domain and a C-terminal pleckstrin homology (PH) domain and is recruited to the cell membrane in a PI3K-dependent manner following BCR crosslinking." [PubMed:15626471]
exact_synonym: "3' phosphoinositide-interacting SH2 domain-containing protein" []
exact_synonym: "B lymphocyte adaptor molecule of 32 kDa" []
exact_synonym: "DAPP1" []
exact_synonym: "dual-adaptor for phosphotyrosine and 3-phosphoinositides-1" []
exact_synonym: "PHISH" []
is_a: IMR:0000333 ! adaptor protein

[Term]
id: IMR:0002137
name: DAPP1_HUMAN
exact_synonym: "B lymphocyte adapter protein Bam32" [UniProt:Q9UN19]
exact_synonym: "B-cell adapter molecule of 32 kDa" [UniProt:Q9UN19]
exact_synonym: "B-CELL ADAPTOR MOLECULE, 32-KD" [MIM:605768]
exact_synonym: "BAM32" [HGNC:16500, UniProt:Q9UN19, EntrezGene:27071, MIM:605768]
exact_synonym: "DAPP1" [HGNC:16500, UniProt:Q9UN19, EntrezGene:27071, MIM:605768]
exact_synonym: "DKFZp667E0716" [EntrezGene:27071]
exact_synonym: "Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide" [UniProt:Q9UN19]
exact_synonym: "dual adaptor of phosphotyrosine and 3-phosphoinositides" [HGNC:16500, EntrezGene:27071]
exact_synonym: "DUAL ADAPTOR OF PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDES 1" [MIM:605768]
exact_synonym: "hDAPP1" [UniProt:Q9UN19]
xref_analog: UniProt:Q9UN19
relationship: sequence_of IMR:0002136 ! Bam32

[Term]
id: IMR:0002138
name: DAPP1_MOUSE
exact_synonym: "B lymphocyte adapter protein Bam32" [UniProt:Q9QXT1]
exact_synonym: "B-cell adapter molecule of 32 kDa" [UniProt:Q9QXT1]
exact_synonym: "Bam32" [UniProt:Q9QXT1, MGI:1347063]
exact_synonym: "Dapp1" [UniProt:Q9QXT1, MGI:1347063]
exact_synonym: "Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide" [UniProt:Q9QXT1]
exact_synonym: "dual adaptor for phosphotyrosine and 3-phosphoinositides 1" [MGI:1347063]
exact_synonym: "mDAPP1" [UniProt:Q9QXT1]
xref_analog: UniProt:Q9QXT1
relationship: sequence_of IMR:0002136 ! Bam32

[Term]
id: IMR:0002139
name: HV101_HUMAN
exact_synonym: "Ig heavy chain V-I region EU" [UniProt:P01742]
xref_analog: UniProt:P01742
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002140
name: HV104_HUMAN
exact_synonym: "Ig heavy chain V-I region ND" [UniProt:P01744]
xref_analog: UniProt:P01744
relationship: sequence_of IMR:0002100 ! epsilon heavy chain

[Term]
id: IMR:0002141
name: HV105_HUMAN
exact_synonym: "Ig heavy chain V-I region WOL" [UniProt:P01760]
xref_analog: UniProt:P01760
relationship: sequence_of IMR:0002104 ! mu heavy chain

[Term]
id: IMR:0002142
name: HV106_HUMAN
exact_synonym: "Ig heavy chain V-I region SIE" [UniProt:P01761]
xref_analog: UniProt:P01761
relationship: sequence_of IMR:0002104 ! mu heavy chain

[Term]
id: IMR:0002143
name: HV201_HUMAN
exact_synonym: "Ig heavy chain V-II region OU" [UniProt:P01814]
xref_analog: UniProt:P01814
relationship: sequence_of IMR:0002104 ! mu heavy chain

[Term]
id: IMR:0002144
name: HV202_HUMAN
exact_synonym: "Ig heavy chain V-II region COR" [UniProt:P01815]
xref_analog: UniProt:P01815
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002145
name: HV203_HUMAN
exact_synonym: "Ig heavy chain V-II region DAW" [UniProt:P01816]
xref_analog: UniProt:P01816
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002146
name: HV204_HUMAN
exact_synonym: "Ig heavy chain V-II region MCE" [UniProt:P01817]
xref_analog: UniProt:P01817
relationship: sequence_of IMR:0002104 ! mu heavy chain

[Term]
id: IMR:0002147
name: HV205_HUMAN
exact_synonym: "Ig heavy chain V-II region HE" [UniProt:P01818]
xref_analog: UniProt:P01818
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002148
name: HV206_HUMAN
exact_synonym: "Ig heavy chain V-II region WAH" [UniProt:P01824]
xref_analog: UniProt:P01824
relationship: sequence_of IMR:0002099 ! delta heavy chain

[Term]
id: IMR:0002149
name: HV207_HUMAN
exact_synonym: "Ig heavy chain V-II region NEWM" [UniProt:P01825]
xref_analog: UniProt:P01825
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002150
name: HV301_HUMAN
exact_synonym: "Ig heavy chain V-III region TRO" [UniProt:P01762]
xref_analog: UniProt:P01762
relationship: sequence_of IMR:0002098 ! alpha heavy chain

[Term]
id: IMR:0002151
name: HV302_HUMAN
exact_synonym: "Ig heavy chain V-III region WEA" [UniProt:P01763]
xref_analog: UniProt:P01763
relationship: sequence_of IMR:0002104 ! mu heavy chain

[Term]
id: IMR:0002152
name: HV305_HUMAN
exact_synonym: "Ig heavy chain V-III region BRO" [UniProt:P01766]
xref_analog: UniProt:P01766
relationship: sequence_of IMR:0002104 ! mu heavy chain

[Term]
id: IMR:0002153
name: HV306_HUMAN
exact_synonym: "Ig heavy chain V-III region BUT" [UniProt:P01767]
xref_analog: UniProt:P01767
relationship: sequence_of IMR:0002098 ! alpha heavy chain

[Term]
id: IMR:0002154
name: HV307_HUMAN
exact_synonym: "Ig heavy chain V-III region CAM" [UniProt:P01768]
xref_analog: UniProt:P01768
relationship: sequence_of IMR:0002104 ! mu heavy chain

[Term]
id: IMR:0002155
name: HV309_HUMAN
exact_synonym: "Ig heavy chain V-III region NIE" [UniProt:P01770]
xref_analog: UniProt:P01770
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002156
name: HV310_HUMAN
exact_synonym: "Ig heavy chain V-III region HIL" [UniProt:P01771]
xref_analog: UniProt:P01771
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002157
name: HV313_HUMAN
exact_synonym: "Ig heavy chain V-III region POM" [UniProt:P01774]
xref_analog: UniProt:P01774
relationship: sequence_of IMR:0002104 ! mu heavy chain

[Term]
id: IMR:0002158
name: HV314_HUMAN
exact_synonym: "Ig heavy chain V-III region LAY" [UniProt:P01775]
xref_analog: UniProt:P01775
relationship: sequence_of IMR:0002104 ! mu heavy chain

[Term]
id: IMR:0002159
name: HV315_HUMAN
exact_synonym: "Ig heavy chain V-III region WAS" [UniProt:P01776]
xref_analog: UniProt:P01776
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002160
name: HV316_HUMAN
exact_synonym: "Ig heavy chain V-III region TEI" [UniProt:P01777]
xref_analog: UniProt:P01777
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002161
name: HV317_HUMAN
exact_synonym: "Ig heavy chain V-III region ZAP" [UniProt:P01778]
xref_analog: UniProt:P01778
relationship: sequence_of IMR:0002098 ! alpha heavy chain

[Term]
id: IMR:0002162
name: HV318_HUMAN
exact_synonym: "Ig heavy chain V-III region TUR" [UniProt:P01779]
xref_analog: UniProt:P01779
relationship: sequence_of IMR:0002098 ! alpha heavy chain

[Term]
id: IMR:0002163
name: HV319_HUMAN
exact_synonym: "Ig heavy chain V-III region JON" [UniProt:P01780]
xref_analog: UniProt:P01780
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002164
name: HV320_HUMAN
exact_synonym: "Ig heavy chain V-III region GAL" [UniProt:P01781]
xref_analog: UniProt:P01781
relationship: sequence_of IMR:0002104 ! mu heavy chain

[Term]
id: IMR:0002165
name: HV321_HUMAN
exact_synonym: "Ig heavy chain V-III region DOB" [UniProt:P01782]
xref_analog: UniProt:P01782
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002166
name: IGKC_HUMAN
exact_synonym: "HCAK1" [EntrezGene:3514, HGNC:5716]
exact_synonym: "Ig kappa chain C region" [UniProt:P01834]
exact_synonym: "IGKC" [UniProt:P01834, EntrezGene:3514, HGNC:5716]
exact_synonym: "immunoglobulin kappa constant" [EntrezGene:3514, HGNC:5716]
exact_synonym: "Km" [EntrezGene:3514]
exact_synonym: "MGC111575" [EntrezGene:3514]
exact_synonym: "MGC62011" [EntrezGene:3514]
exact_synonym: "MGC72072" [EntrezGene:3514]
exact_synonym: "MGC88770" [EntrezGene:3514]
exact_synonym: "MGC88771" [EntrezGene:3514]
exact_synonym: "MGC88809" [EntrezGene:3514]
xref_analog: UniProt:P01834
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002167
name: KV101_HUMAN
exact_synonym: "Ig kappa chain V-I region AG" [UniProt:P01593]
xref_analog: UniProt:P01593
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002168
name: KV102_HUMAN
exact_synonym: "Ig kappa chain V-I region AU" [UniProt:P01594]
xref_analog: UniProt:P01594
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002169
name: KV103_HUMAN
exact_synonym: "Ig kappa chain V-I region Bi" [UniProt:P01595]
xref_analog: UniProt:P01595
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002170
name: KV104_HUMAN
exact_synonym: "Ig kappa chain V-I region CAR" [UniProt:P01596]
xref_analog: UniProt:P01596
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002171
name: KV105_HUMAN
exact_synonym: "Ig kappa chain V-I region DEE" [UniProt:P01597]
xref_analog: UniProt:P01597
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002172
name: KV106_HUMAN
exact_synonym: "Ig kappa chain V-I region EU" [UniProt:P01598]
xref_analog: UniProt:P01598
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002173
name: KV107_HUMAN
exact_synonym: "Ig kappa chain V-I region Gal" [UniProt:P01599]
xref_analog: UniProt:P01599
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002174
name: KV108_HUMAN
exact_synonym: "Ig kappa chain V-I region Hau" [UniProt:P01600]
xref_analog: UniProt:P01600
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002175
name: KV109_HUMAN
exact_synonym: "Ig kappa chain V-I region HK101" [UniProt:P01601]
xref_analog: UniProt:P01601
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002176
name: KV110_HUMAN
exact_synonym: "Ig kappa chain V-I region HK102" [UniProt:P01602]
exact_synonym: "IGKV" [EntrezGene:28299]
exact_synonym: "IGKV1-5" [UniProt:P01602, EntrezGene:28299, HGNC:5741]
exact_synonym: "IGKV15" [EntrezGene:28299]
exact_synonym: "immunoglobulin kappa variable 1-5" [EntrezGene:28299, HGNC:5741]
exact_synonym: "L12" [EntrezGene:28299]
exact_synonym: "L12a" [EntrezGene:28299]
exact_synonym: "MGC22745" [EntrezGene:28299]
exact_synonym: "MGC32715" [EntrezGene:28299]
exact_synonym: "MGC88810" [EntrezGene:28299]
exact_synonym: "V1" [EntrezGene:28299]
xref_analog: UniProt:P01602
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002177
name: KV111_HUMAN
exact_synonym: "Ig kappa chain V-I region Ka" [UniProt:P01603]
xref_analog: UniProt:P01603
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002178
name: KV112_HUMAN
exact_synonym: "Ig kappa chain V-I region Kue" [UniProt:P01604]
xref_analog: UniProt:P01604
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002179
name: KV113_HUMAN
exact_synonym: "Ig kappa chain V-I region Lay" [UniProt:P01605]
xref_analog: UniProt:P01605
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002180
name: KV114_HUMAN
exact_synonym: "Ig kappa chain V-I region OU" [UniProt:P01606]
xref_analog: UniProt:P01606
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002181
name: KV115_HUMAN
exact_synonym: "Ig kappa chain V-I region Rei" [UniProt:P01607]
xref_analog: UniProt:P01607
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002182
name: KV116_HUMAN
exact_synonym: "Ig kappa chain V-I region Roy" [UniProt:P01608]
xref_analog: UniProt:P01608
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002183
name: KV117_HUMAN
exact_synonym: "Ig kappa chain V-I region Scw" [UniProt:P01609]
xref_analog: UniProt:P01609
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002184
name: KV118_HUMAN
exact_synonym: "Ig kappa chain V-I region WEA" [UniProt:P01610]
xref_analog: UniProt:P01610
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002185
name: KV119_HUMAN
exact_synonym: "Ig kappa chain V-I region Wes" [UniProt:P01611]
xref_analog: UniProt:P01611
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002186
name: KV120_HUMAN
exact_synonym: "Ig kappa chain V-I region Mev" [UniProt:P01612]
xref_analog: UniProt:P01612
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002187
name: KV121_HUMAN
exact_synonym: "Ig kappa chain V-I region Ni" [UniProt:P01613]
xref_analog: UniProt:P01613
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002188
name: KV122_HUMAN
exact_synonym: "Ig kappa chain V-I region BAN" [UniProt:P04430]
xref_analog: UniProt:P04430
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002189
name: KV123_HUMAN
exact_synonym: "Ig kappa chain V-I region Walker" [UniProt:P04431]
xref_analog: UniProt:P04431
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002190
name: KV124_HUMAN
exact_synonym: "Ig kappa chain V-I region Daudi" [UniProt:P04432]
xref_analog: UniProt:P04432
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002191
name: KV125_HUMAN
exact_synonym: "Ig kappa chain V-I region WAT" [UniProt:P80362]
xref_analog: UniProt:P80362
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002192
name: KV201_HUMAN
exact_synonym: "Ig kappa chain V-II region Cum" [UniProt:P01614]
xref_analog: UniProt:P01614
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002193
name: KV202_HUMAN
exact_synonym: "Ig kappa chain V-II region FR" [UniProt:P01615]
xref_analog: UniProt:P01615
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002194
name: KV203_HUMAN
exact_synonym: "Ig kappa chain V-II region MIL" [UniProt:P01616]
xref_analog: UniProt:P01616
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002195
name: KV204_HUMAN
exact_synonym: "Ig kappa chain V-II region TEW" [UniProt:P01617]
xref_analog: UniProt:P01617
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002196
name: KV205_HUMAN
exact_synonym: "Ig kappa chain V-II region GM607" [UniProt:P06309]
xref_analog: UniProt:P06309
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002197
name: KV206_HUMAN
exact_synonym: "Ig kappa chain V-II region RPMI 6410" [UniProt:P06310]
xref_analog: UniProt:P06310
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002198
name: KV301_HUMAN
exact_synonym: "Ig kappa chain V-III region B6" [UniProt:P01619]
xref_analog: UniProt:P01619
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002199
name: KV302_HUMAN
exact_synonym: "Ig kappa chain V-III region SIE" [UniProt:P01620]
xref_analog: UniProt:P01620
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002200
name: KV303_HUMAN
exact_synonym: "Ig kappa chain V-III region NG9" [UniProt:P01621]
xref_analog: UniProt:P01621
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002201
name: KV304_HUMAN
exact_synonym: "Ig kappa chain V-III region Ti" [UniProt:P01622]
xref_analog: UniProt:P01622
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002202
name: KV305_HUMAN
exact_synonym: "Ig kappa chain V-III region WOL" [UniProt:P01623]
xref_analog: UniProt:P01623
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002203
name: KV306_HUMAN
exact_synonym: "Ig kappa chain V-III region POM" [UniProt:P01624]
xref_analog: UniProt:P01624
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002204
name: KV307_HUMAN
exact_synonym: "Ig kappa chain V-III region GOL" [UniProt:P04206]
exact_synonym: "Rheumatoid factor" [UniProt:P04206]
xref_analog: UniProt:P04206
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002205
name: KV308_HUMAN
exact_synonym: "Ig kappa chain V-III region CLL" [UniProt:P04207]
exact_synonym: "Rheumatoid factor" [UniProt:P04207]
xref_analog: UniProt:P04207
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002206
name: KV309_HUMAN
exact_synonym: "Ig kappa chain V-III region VG" [UniProt:P04433]
xref_analog: UniProt:P04433
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002207
name: KV310_HUMAN
exact_synonym: "Ig kappa chain V-III region VH" [UniProt:P04434]
xref_analog: UniProt:P04434
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002208
name: KV311_HUMAN
exact_synonym: "Ig kappa chain V-III region IARC/BL41" [UniProt:P06311]
xref_analog: UniProt:P06311
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002209
name: KV312_HUMAN
exact_synonym: "Ig kappa chain V-III region HAH" [UniProt:P18135]
xref_analog: UniProt:P18135
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002210
name: KV313_HUMAN
exact_synonym: "Ig kappa chain V-III region HIC" [UniProt:P18136]
xref_analog: UniProt:P18136
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002211
name: KV401_HUMAN
exact_synonym: "B3" [EntrezGene:28908, HGNC:5834]
exact_synonym: "Ig kappa chain V-IV region" [UniProt:P06312]
exact_synonym: "IGKV4-1" [EntrezGene:28908, UniProt:P06312, HGNC:5834]
exact_synonym: "IGKV41" [EntrezGene:28908, HGNC:5834]
exact_synonym: "immunoglobulin kappa variable 4-1" [EntrezGene:28908, HGNC:5834]
xref_analog: UniProt:P06312
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002212
name: KV402_HUMAN
exact_synonym: "Ig kappa chain V-IV region Len" [UniProt:P01625]
xref_analog: UniProt:P01625
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002213
name: KV403_HUMAN
exact_synonym: "Ig kappa chain V-IV region JI" [UniProt:P06313]
xref_analog: UniProt:P06313
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002214
name: KV404_HUMAN
exact_synonym: "Ig kappa chain V-IV region B17" [UniProt:P06314]
xref_analog: UniProt:P06314
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002215
name: KV405_HUMAN
exact_synonym: "Ig kappa chain V-IV region STH" [UniProt:P83593]
xref_analog: UniProt:P83593
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002216
name: KV501_HUMAN
exact_synonym: "Ig kappa chain V region EV15" [UniProt:P06315]
xref_analog: UniProt:P06315
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002217
name: LAC1_HUMAN
exact_synonym: "Ig lambda-1 chain C regions" [UniProt:P0CG04]
exact_synonym: "IGLC" [MIM:147220, EntrezGene:3537]
exact_synonym: "IGLC1" [HGNC:5855, MIM:147220, UniProt:P0CG04, EntrezGene:3537]
exact_synonym: "IGLC2" [EntrezGene:3537]
exact_synonym: "immunoglobulin lambda constant 1 (Mcg marker)" [HGNC:5855, EntrezGene:3537]
exact_synonym: "IMMUNOGLOBULIN LAMBDA CONSTANT REGION 1" [MIM:147220]
exact_synonym: "IMMUNOGLOBULIN: LAMBDA LIGHT CHAIN" [MIM:147220]
xref_analog: UniProt:P0CG04
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002218
name: LV001_HUMAN
exact_synonym: "Ig lambda chain V region 4A" [UniProt:P04211]
xref_analog: UniProt:P04211
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002219
name: LV101_HUMAN
exact_synonym: "Ig lambda chain V-I region VOR" [UniProt:P01699]
xref_analog: UniProt:P01699
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002220
name: LV102_HUMAN
exact_synonym: "Ig lambda chain V-I region HA" [UniProt:P01700]
xref_analog: UniProt:P01700
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002221
name: LV103_HUMAN
exact_synonym: "Ig lambda chain V-I region NEW" [UniProt:P01701]
xref_analog: UniProt:P01701
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002222
name: LV104_HUMAN
exact_synonym: "Ig lambda chain V-I region NIG-64" [UniProt:P01702]
xref_analog: UniProt:P01702
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002223
name: LV105_HUMAN
exact_synonym: "Ig lambda chain V-I region NEWM" [UniProt:P01703]
xref_analog: UniProt:P01703
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002224
name: LV106_HUMAN
exact_synonym: "Ig lambda chain V-I region WAH" [UniProt:P04208]
xref_analog: UniProt:P04208
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002225
name: LV107_HUMAN
exact_synonym: "Ig lambda chain V-I region BL2" [UniProt:P06316]
xref_analog: UniProt:P06316
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002226
name: LV108_HUMAN
exact_synonym: "Ig lambda chain V-I region MEM" [UniProt:P06887]
xref_analog: UniProt:P06887
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002227
name: LV109_HUMAN
exact_synonym: "Ig lambda chain V-I region EPS" [UniProt:P06888]
xref_analog: UniProt:P06888
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002228
name: LV201_HUMAN
exact_synonym: "Ig lambda chain V-II region TOG" [UniProt:P01704]
xref_analog: UniProt:P01704
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002229
name: LV202_HUMAN
exact_synonym: "Ig lambda chain V-II region NEI" [UniProt:P01705]
xref_analog: UniProt:P01705
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002230
name: LV203_HUMAN
exact_synonym: "Ig lambda chain V-II region BOH" [UniProt:P01706]
xref_analog: UniProt:P01706
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002231
name: LV204_HUMAN
exact_synonym: "Ig lambda chain V-II region TRO" [UniProt:P01707]
xref_analog: UniProt:P01707
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002232
name: LV205_HUMAN
exact_synonym: "Ig lambda chain V-II region BUR" [UniProt:P01708]
xref_analog: UniProt:P01708
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002233
name: LV206_HUMAN
exact_synonym: "Ig lambda chain V-II region MGC" [UniProt:P01709]
xref_analog: UniProt:P01709
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002234
name: LV207_HUMAN
exact_synonym: "Ig lambda chain V-II region BO" [UniProt:P01710]
xref_analog: UniProt:P01710
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002235
name: LV208_HUMAN
exact_synonym: "Ig lambda chain V-II region VIL" [UniProt:P01711]
xref_analog: UniProt:P01711
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002236
name: LV209_HUMAN
exact_synonym: "Ig lambda chain V-II region WIN" [UniProt:P01712]
xref_analog: UniProt:P01712
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002237
name: LV210_HUMAN
exact_synonym: "Ig lambda chain V-II region NIG-58" [UniProt:P01713]
xref_analog: UniProt:P01713
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002238
name: LV211_HUMAN
exact_synonym: "Ig lambda chain V-II region NIG-84" [UniProt:P04209]
xref_analog: UniProt:P04209
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002239
name: LV212_HUMAN
exact_synonym: "Ig gamma lambda chain V-II region DOT" [UniProt:P80422]
xref_analog: UniProt:P80422
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002240
name: LV301_HUMAN
exact_synonym: "Ig lambda chain V-III region SH" [UniProt:P01714]
xref_analog: UniProt:P01714
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002241
name: LV302_HUMAN
exact_synonym: "Ig lambda chain V-III region LOI" [UniProt:P80748]
xref_analog: UniProt:P80748
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002242
name: LV401_HUMAN
exact_synonym: "Ig lambda chain V-IV region Bau" [UniProt:P01715]
xref_analog: UniProt:P01715
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002243
name: LV402_HUMAN
exact_synonym: "Ig lambda chain V-IV region X" [UniProt:P01716]
xref_analog: UniProt:P01716
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002244
name: LV403_HUMAN
exact_synonym: "Ig lambda chain V-IV region Hil" [UniProt:P01717]
xref_analog: UniProt:P01717
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002245
name: LV404_HUMAN
exact_synonym: "Ig lambda chain V-IV region Kern" [UniProt:P01718]
xref_analog: UniProt:P01718
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002246
name: LV405_HUMAN
exact_synonym: "Ig lambda chain V-IV region MOL" [UniProt:P06889]
xref_analog: UniProt:P06889
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002247
name: LV501_HUMAN
exact_synonym: "Ig lambda chain V-V region DEL" [UniProt:P01719]
xref_analog: UniProt:P01719
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002248
name: LV601_HUMAN
exact_synonym: "Ig lambda chain V-VI region AR" [UniProt:P01721]
xref_analog: UniProt:P01721
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002249
name: LV602_HUMAN
exact_synonym: "Ig lambda chain V-VI region NIG-48" [UniProt:P01722]
xref_analog: UniProt:P01722
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002250
name: LV603_HUMAN
exact_synonym: "Ig lambda chain V-VI region SUT" [UniProt:P06317]
xref_analog: UniProt:P06317
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002251
name: LV604_HUMAN
exact_synonym: "Ig lambda chain V-VI region WLT" [UniProt:P06318]
xref_analog: UniProt:P06318
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002252
name: LV605_HUMAN
exact_synonym: "Ig lambda chain V-VI region EB4" [UniProt:P06319]
xref_analog: UniProt:P06319
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002253
name: LV701_HUMAN
exact_synonym: "Ig lambda chain V-VII region MOT" [UniProt:P01720]
xref_analog: UniProt:P01720
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002254
name: IGHG3_MOUSE
alt_id: IMR:0002255
comment: This entry describes 2 isoforms produced by alternative splicing. Membrane bound form and secreted form.
exact_synonym: "Ig gamma-3 chain C region" [UniProt:P03987]
xref_analog: UniProt:P03987
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002256
name: GCAA_MOUSE
exact_synonym: "Ig gamma-2A chain C region, A allele" [UniProt:P01863]
exact_synonym: "Ighg" [UniProt:P01863, MGI:2144967]
exact_synonym: "Immunoglobulin heavy chain (gamma polypeptide)" [MGI:2144967]
exact_synonym: "Immunoglobulin heavy chain gamma polypeptide" [UniProt:P01863]
xref_analog: UniProt:P01863
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002257
name: GCAB_MOUSE
exact_synonym: "B allele" [UniProt:P01864]
exact_synonym: "Ig gamma-2A chain C region secreted form" [UniProt:P01864]
xref_analog: UniProt:P01864
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002258
name: GCAM_MOUSE
exact_synonym: "Ig gamma-2A chain C region, membrane-bound form" [UniProt:P01865]
exact_synonym: "Igh-1" [MGI:96443]
exact_synonym: "Igh-1a" [UniProt:P01865]
exact_synonym: "Ighg2a" [MGI:96443]
exact_synonym: "immunoglobulin heavy constant gamma 2A" [MGI:96443]
xref_analog: UniProt:P01865
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002259
name: IGG2B_MOUSE
alt_id: IMR:0002260
exact_synonym: "gamma2b" [MGI:96445]
exact_synonym: "Ig gamma-2B chain C region" [UniProt:P01867]
exact_synonym: "IgG2b" [MGI:96445]
exact_synonym: "Igh-3" [UniProt:P01867]
exact_synonym: "Ighg2b" [MGI:96445]
exact_synonym: "immunoglobulin heavy constant gamma 2B" [MGI:96445]
xref_analog: UniProt:P01867
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002261
name: IGH1M_MOUSE
exact_synonym: "Ig gamma-1 chain C region, membrane-bound form" [UniProt:P01869]
exact_synonym: "IgG1" [MGI:96446]
exact_synonym: "Igh-4" [UniProt:P01869, MGI:96446]
exact_synonym: "Ighg1" [UniProt:P01869, MGI:96446]
exact_synonym: "immunoglobulin heavy constant gamma 1 (G1m marker)" [MGI:96446]
xref_analog: UniProt:P01869
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002262
name: IGHE_MOUSE
exact_synonym: "Ig epsilon chain C region" [UniProt:P06336]
xref_analog: UniProt:P06336
relationship: sequence_of IMR:0002100 ! epsilon heavy chain

[Term]
id: IMR:0002263
name: MUCM_MOUSE
exact_synonym: "Ig mu" [MGI:96448]
exact_synonym: "Ig mu chain C region membrane-bound form" [UniProt:P01873]
exact_synonym: "Igh-6" [UniProt:P01873]
exact_synonym: "Igh-M" [MGI:96448]
exact_synonym: "Igh6" [MGI:96448]
exact_synonym: "Ighm" [MGI:96448]
exact_synonym: "IgM" [MGI:96448]
exact_synonym: "immunoglobulin heavy constant mu" [MGI:96448]
exact_synonym: "muH" [MGI:96448]
xref_analog: UniProt:P01873
relationship: sequence_of IMR:0002104 ! mu heavy chain

[Term]
id: IMR:0002264
name: IGHM_MOUSE
exact_synonym: "Ig mu" [MGI:96448]
exact_synonym: "Ig mu chain C region secreted form" [UniProt:P01872]
exact_synonym: "Igh-6" [UniProt:P01872]
exact_synonym: "Igh-M" [MGI:96448]
exact_synonym: "Igh6" [MGI:96448]
exact_synonym: "Ighm" [MGI:96448]
exact_synonym: "IgM" [MGI:96448]
exact_synonym: "immunoglobulin heavy constant mu" [MGI:96448]
exact_synonym: "muH" [MGI:96448]
xref_analog: UniProt:P01872
relationship: sequence_of IMR:0002104 ! mu heavy chain

[Term]
id: IMR:0002265
name: LAC1_MOUSE
exact_synonym: "Ig lambda-1 chain C region" [UniProt:P01843]
xref_analog: UniProt:P01843
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002266
name: LAC2_MOUSE
exact_synonym: "Ig lambda-2 chain C region" [UniProt:P01844]
xref_analog: UniProt:P01844
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002267
name: LAC3_MOUSE
exact_synonym: "Ig lambda-3 chain C region" [UniProt:P01845]
xref_analog: UniProt:P01845
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002268
name: LV1A_MOUSE
exact_synonym: "Ig lambda-1 chain V region" [UniProt:P01723]
xref_analog: UniProt:P01723
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002269
name: LV1B_MOUSE
exact_synonym: "Ig lambda-1 chain V regions MOPC 104E/RPC20/J558/S104" [UniProt:P01724]
xref_analog: UniProt:P01724
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002270
name: LV1C_MOUSE
exact_synonym: "Ig lambda-1 chain V region S178" [UniProt:P01725]
xref_analog: UniProt:P01725
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002271
name: LV1D_MOUSE
exact_synonym: "Ig lambda-1 chain V region H2020" [UniProt:P01726]
xref_analog: UniProt:P01726
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002272
name: LV1E_MOUSE
exact_synonym: "Ig lambda-1 chain V region S43" [UniProt:P01727]
xref_analog: UniProt:P01727
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002273
name: LV2A_MOUSE
exact_synonym: "Ig lambda-2 chain V region" [UniProt:P01728]
xref_analog: UniProt:P01728
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002274
name: LV2B_MOUSE
exact_synonym: "Ig lambda-2 chain V region MOPC 315" [UniProt:P01729]
xref_analog: UniProt:P01729
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002275
name: IGHG1_RAT
exact_synonym: "Ig gamma-1 chain C region" [UniProt:P20759]
xref_analog: UniProt:P20759
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002276
name: IGG2A_RAT
exact_synonym: "gamma-2a immunoglobulin heavy chain" [RGD:1359626]
exact_synonym: "Ig gamma-2A chain C region" [UniProt:P20760]
exact_synonym: "Igg-2a" [UniProt:P20760]
exact_synonym: "IgG-2a" [RGD:1359626]
xref_analog: UniProt:P20760
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002277
name: IGG2B_RAT
exact_synonym: "Ig gamma-2B chain C region" [UniProt:P20761]
exact_synonym: "Igh-1a" [UniProt:P20761]
exact_synonym: "Immunoglobulin heavy chain 1a" [UniProt:P20761]
xref_analog: UniProt:P20761
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002278
name: IGG2C_RAT
exact_synonym: "Ig gamma-2C chain C region" [UniProt:P20762]
xref_analog: UniProt:P20762
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002279
name: HVR01_RAT
exact_synonym: "Ig heavy chain V region IR2" [UniProt:P01805]
xref_analog: UniProt:P01805
relationship: sequence_of IMR:0002100 ! epsilon heavy chain

[Term]
id: IMR:0002280
name: KACA_RAT
exact_synonym: "Ig kappa chain C region, A allele" [UniProt:P01836]
exact_synonym: "LOC500183" [RGD:1562743]
exact_synonym: "similar to NGF-binding Ig light chain" [RGD:1562743]
xref_analog: UniProt:P01836
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002281
name: KACB_RAT
exact_synonym: "Ig kappa chain C region, B allele" [UniProt:P01835]
xref_analog: UniProt:P01835
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002282
name: KVX01_RAT
exact_synonym: "Ig kappa chain V region S211" [UniProt:P01681]
xref_analog: UniProt:P01681
relationship: sequence_of IMR:0002102 ! kappa light chain

[Term]
id: IMR:0002283
name: LAC1_RAT
exact_synonym: "Ig lambda-1 chain C region" [UniProt:P20766]
exact_synonym: "RGD1564318" [RGD:1564318]
exact_synonym: "similar to immunoglobulin light chain variable region" [RGD:1564318]
xref_analog: UniProt:P20766
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002284
name: LAC2_RAT
exact_synonym: "Ig lambda-2 chain C region" [UniProt:P20767]
xref_analog: UniProt:P20767
relationship: sequence_of IMR:0002103 ! lambda light chain

[Term]
id: IMR:0002285
name: HVM00_MOUSE
exact_synonym: "Anti-arsonate antibody" [UniProt:P01741]
exact_synonym: "Ig heavy chain V region" [UniProt:P01741]
xref_analog: UniProt:P01741
relationship: sequence_of IMR:0002101 ! gamma heavy chain

[Term]
id: IMR:0002286
name: KNG1_MOUSE
exact_synonym: "Bradykinin" [UniProt:O08677]
exact_synonym: "H-kininigen" [MGI:1097705]
exact_synonym: "kininogen 1" [MGI:1097705]
exact_synonym: "Kininogen-1" [UniProt:O08677]
exact_synonym: "Kininogen-1 heavy chain" [UniProt:O08677]
exact_synonym: "Kininogen-1 light chain" [UniProt:O08677]
exact_synonym: "Kng" [UniProt:O08677]
exact_synonym: "Kng1" [UniProt:O08677, MGI:1097705]
exact_synonym: "L-kininogen" [MGI:1097705]
xref_analog: UniProt:O08677
relationship: sequence_of IMR:0002126 ! methionyl-lysyl-bradykinin
relationship: sequence_of IMR:0100137 ! bradykinin
relationship: sequence_of IMR:0100138 ! kallidin

[Term]
id: IMR:0002287
name: KNG1_RAT
exact_synonym: "Bradykinin" [UniProt:P08934]
exact_synonym: "kininogen 1" [RGD:2980]
exact_synonym: "Kininogen-1" [UniProt:P08934]
exact_synonym: "Kininogen-1 heavy chain" [UniProt:P08934]
exact_synonym: "Kininogen-1 light chain" [UniProt:P08934]
exact_synonym: "Kng" [UniProt:P08934]
exact_synonym: "Kng1" [RGD:2980, UniProt:P08934]
xref_analog: UniProt:P08934
relationship: sequence_of IMR:0002126 ! methionyl-lysyl-bradykinin
relationship: sequence_of IMR:0100137 ! bradykinin
relationship: sequence_of IMR:0100138 ! kallidin

[Term]
id: IMR:0002288
name: neurokinin B
is_a: IMR:0100139 ! tachykinin

[Term]
id: IMR:0002289
name: neuropeptide gamma
is_a: IMR:0100139 ! tachykinin

[Term]
id: IMR:0002290
name: TKNK_HUMAN
exact_synonym: "NEUROKININ B" [MIM:162330]
exact_synonym: "Neurokinin-B" [UniProt:Q9UHF0]
exact_synonym: "NEUROMEDIN K" [MIM:162330]
exact_synonym: "Neuromedin-K" [UniProt:Q9UHF0]
exact_synonym: "NKB" [MIM:162330, UniProt:Q9UHF0, HGNC:11521, EntrezGene:6866]
exact_synonym: "NKNB" [MIM:162330, UniProt:Q9UHF0, EntrezGene:6866]
exact_synonym: "PRO1155" [EntrezGene:6866]
exact_synonym: "TAC3" [MIM:162330, UniProt:Q9UHF0, HGNC:11521, EntrezGene:6866]
exact_synonym: "tachykinin 3" [MIM:162330, HGNC:11521, EntrezGene:6866]
exact_synonym: "Tachykinin-3" [UniProt:Q9UHF0]
exact_synonym: "ZNEUROK1" [UniProt:Q9UHF0, HGNC:11521, EntrezGene:6866]
xref_analog: UniProt:Q9UHF0
relationship: sequence_of IMR:0002288 ! neurokinin B

[Term]
id: IMR:0002291
name: TKNK_MOUSE
exact_synonym: "neurokinin  alpha" [MGI:98476]
exact_synonym: "neurokinin 2" [MGI:98476]
exact_synonym: "neurokinin A" [MGI:98476]
exact_synonym: "Neurokinin B-like protein Zneurok1" [UniProt:P55099]
exact_synonym: "Neurokinin-B" [UniProt:P55099]
exact_synonym: "neuromedin  L" [MGI:98476]
exact_synonym: "Neuromedin-K" [UniProt:P55099]
exact_synonym: "neuropeptide K" [MGI:98476]
exact_synonym: "NKB" [UniProt:P55099]
exact_synonym: "Nknb" [UniProt:P55099]
exact_synonym: "PPT-B" [UniProt:P55099]
exact_synonym: "Preprotachykinin-B" [UniProt:P55099]
exact_synonym: "substance K" [MGI:98476]
exact_synonym: "Tac2" [UniProt:P55099, MGI:98476]
exact_synonym: "Tac3" [UniProt:P55099]
exact_synonym: "tachykinin 2" [MGI:98476]
exact_synonym: "Tachykinin-3" [UniProt:P55099]
xref_analog: UniProt:P55099
relationship: sequence_of IMR:0002288 ! neurokinin B

[Term]
id: IMR:0002292
name: TKNK_RAT
exact_synonym: "Neurokinin-B" [UniProt:P08435]
exact_synonym: "Neuromedin-K" [UniProt:P08435]
exact_synonym: "NKB" [UniProt:P08435]
exact_synonym: "Nknb" [UniProt:P08435]
exact_synonym: "Tac2" [UniProt:P08435, RGD:3809]
exact_synonym: "Tac3" [UniProt:P08435]
exact_synonym: "tachykinin 2" [RGD:3809]
exact_synonym: "Tachykinin-3" [UniProt:P08435]
xref_analog: UniProt:P08435
relationship: sequence_of IMR:0002288 ! neurokinin B

[Term]
id: IMR:0002293
name: CCKN_HUMAN
exact_synonym: "(1-49)-CCK58" [UniProt:P06307]
exact_synonym: "CCK" [UniProt:P06307, MIM:118440, EntrezGene:885, HGNC:1569]
exact_synonym: "CCK12" [UniProt:P06307]
exact_synonym: "CCK18" [UniProt:P06307]
exact_synonym: "CCK25" [UniProt:P06307]
exact_synonym: "CCK33" [UniProt:P06307]
exact_synonym: "CCK39" [UniProt:P06307]
exact_synonym: "CCK5" [UniProt:P06307]
exact_synonym: "CCK58" [UniProt:P06307]
exact_synonym: "CCK7" [UniProt:P06307]
exact_synonym: "CCK8" [UniProt:P06307]
exact_synonym: "Cholecystokinin" [UniProt:P06307, MIM:118440]
exact_synonym: "cholecystokinin" [EntrezGene:885, HGNC:1569]
exact_synonym: "Cholecystokinin-12" [UniProt:P06307]
exact_synonym: "Cholecystokinin-18" [UniProt:P06307]
exact_synonym: "Cholecystokinin-25" [UniProt:P06307]
exact_synonym: "Cholecystokinin-33" [UniProt:P06307]
exact_synonym: "Cholecystokinin-39" [UniProt:P06307]
exact_synonym: "Cholecystokinin-5" [UniProt:P06307]
exact_synonym: "Cholecystokinin-58" [UniProt:P06307]
exact_synonym: "Cholecystokinin-58 desnonopeptide" [UniProt:P06307]
exact_synonym: "Cholecystokinin-7" [UniProt:P06307]
exact_synonym: "Cholecystokinin-8" [UniProt:P06307]
exact_synonym: "MGC117187" [EntrezGene:885]
xref_analog: UniProt:P06307
relationship: sequence_of IMR:0100048 ! cholecystokinin

[Term]
id: IMR:0002294
name: CCKN_MOUSE
exact_synonym: "CCK" [UniProt:P09240]
exact_synonym: "Cck" [MGI:88297, UniProt:P09240]
exact_synonym: "CCK12" [UniProt:P09240]
exact_synonym: "CCK33" [UniProt:P09240]
exact_synonym: "CCK8" [UniProt:P09240]
exact_synonym: "Cholecystokinin" [UniProt:P09240]
exact_synonym: "cholecystokinin" [MGI:88297]
exact_synonym: "Cholecystokinin-12" [UniProt:P09240]
exact_synonym: "Cholecystokinin-33" [UniProt:P09240]
exact_synonym: "Cholecystokinin-8" [UniProt:P09240]
xref_analog: UniProt:P09240
relationship: sequence_of IMR:0100048 ! cholecystokinin

[Term]
id: IMR:0002295
name: CCKN_RAT
exact_synonym: "CCK" [UniProt:P01355]
exact_synonym: "Cck" [UniProt:P01355, RGD:2288]
exact_synonym: "CCK12" [UniProt:P01355]
exact_synonym: "CCK22" [UniProt:P01355]
exact_synonym: "CCK33" [UniProt:P01355]
exact_synonym: "CCK39" [UniProt:P01355]
exact_synonym: "CCK8" [UniProt:P01355]
exact_synonym: "Cholecystokinin" [UniProt:P01355]
exact_synonym: "cholecystokinin" [RGD:2288]
exact_synonym: "Cholecystokinin-12" [UniProt:P01355]
exact_synonym: "Cholecystokinin-22" [UniProt:P01355]
exact_synonym: "Cholecystokinin-33" [UniProt:P01355]
exact_synonym: "Cholecystokinin-39" [UniProt:P01355]
exact_synonym: "Cholecystokinin-8" [UniProt:P01355]
xref_analog: UniProt:P01355
relationship: sequence_of IMR:0100048 ! cholecystokinin

[Term]
id: IMR:0002296
name: GIP_HUMAN
exact_synonym: "Gastric inhibitory polypeptide" [MIM:137240, UniProt:P09681]
exact_synonym: "gastric inhibitory polypeptide" [HGNC:4270, EntrezGene:2695]
exact_synonym: "GIP" [HGNC:4270, EntrezGene:2695, MIM:137240, UniProt:P09681]
exact_synonym: "Glucose-dependent insulinotropic polypeptide" [MIM:137240, UniProt:P09681]
xref_analog: UniProt:P09681
relationship: sequence_of IMR:0100050 ! gastric inhibitory polypeptide

[Term]
id: IMR:0002297
name: GIP_MOUSE
exact_synonym: "Gastric inhibitory polypeptide" [UniProt:P48756]
exact_synonym: "gastric inhibitory polypeptide" [MGI:107504]
exact_synonym: "Gip" [UniProt:P48756, MGI:107504]
exact_synonym: "GIP" [UniProt:P48756]
exact_synonym: "Glucose-dependent insulinotropic polypeptide" [UniProt:P48756]
xref_analog: UniProt:P48756
relationship: sequence_of IMR:0100050 ! gastric inhibitory polypeptide

[Term]
id: IMR:0002298
name: GIP_RAT
exact_synonym: "Gastric inhibitory polypeptide" [UniProt:Q06145]
exact_synonym: "gastric inhibitory polypeptide" [RGD:2709]
exact_synonym: "Gip" [UniProt:Q06145, RGD:2709]
exact_synonym: "GIP" [UniProt:Q06145]
exact_synonym: "Glucose-dependent insulinotropic polypeptide" [UniProt:Q06145]
xref_analog: UniProt:Q06145
relationship: sequence_of IMR:0100050 ! gastric inhibitory polypeptide

[Term]
id: IMR:0002299
name: GAST_HUMAN
exact_synonym: "Big gastrin" [UniProt:P01350]
exact_synonym: "G14" [UniProt:P01350]
exact_synonym: "G17" [UniProt:P01350]
exact_synonym: "G34" [UniProt:P01350]
exact_synonym: "G52" [UniProt:P01350]
exact_synonym: "G6" [UniProt:P01350]
exact_synonym: "GAS" [MIM:137250, UniProt:P01350]
exact_synonym: "GAST" [HGNC:4164, UniProt:P01350]
exact_synonym: "Gastrin" [MIM:137250, UniProt:P01350]
exact_synonym: "gastrin" [HGNC:4164]
exact_synonym: "Gastrin component I" [UniProt:P01350]
exact_synonym: "Gastrin component II" [UniProt:P01350]
exact_synonym: "Gastrin component III" [UniProt:P01350]
exact_synonym: "Gastrin-14" [UniProt:P01350]
exact_synonym: "Gastrin-17" [UniProt:P01350]
exact_synonym: "Gastrin-34" [UniProt:P01350]
exact_synonym: "Gastrin-52" [UniProt:P01350]
exact_synonym: "Gastrin-6" [UniProt:P01350]
exact_synonym: "Gastrin-71" [UniProt:P01350]
xref_analog: UniProt:P01350
relationship: sequence_of IMR:0100211 ! gastrin

[Term]
id: IMR:0002300
name: GAST_MOUSE
exact_synonym: "Big gastrin" [UniProt:P48757]
exact_synonym: "G34" [UniProt:P48757]
exact_synonym: "G71" [UniProt:P48757]
exact_synonym: "Gas" [UniProt:P48757]
exact_synonym: "GAS" [MGI:104768]
exact_synonym: "Gast" [MGI:104768, UniProt:P48757]
exact_synonym: "Gastrin" [UniProt:P48757]
exact_synonym: "gastrin" [MGI:104768]
exact_synonym: "Gastrin-34" [UniProt:P48757]
exact_synonym: "Gastrin-71" [UniProt:P48757]
xref_analog: UniProt:P48757
relationship: sequence_of IMR:0100211 ! gastrin

[Term]
id: IMR:0002301
name: GAST_RAT
exact_synonym: "Big gastrin" [UniProt:P04563]
exact_synonym: "G34" [UniProt:P04563]
exact_synonym: "Gas" [UniProt:P04563]
exact_synonym: "Gast" [RGD:2662, UniProt:P04563]
exact_synonym: "Gastrin" [UniProt:P04563]
exact_synonym: "gastrin" [RGD:2662]
exact_synonym: "Gastrin-34" [UniProt:P04563]
xref_analog: UniProt:P04563
relationship: sequence_of IMR:0100211 ! gastrin

[Term]
id: IMR:0002302
name: GRP_HUMAN
exact_synonym: "BN" [EntrezGene:2922, MIM:137260]
exact_synonym: "BOMBESIN" [MIM:137260]
exact_synonym: "Gastrin-releasing peptide" [UniProt:P07492]
exact_synonym: "gastrin-releasing peptide" [HGNC:4605, EntrezGene:2922]
exact_synonym: "GASTRIN-RELEASING POLYPEPTIDE" [MIM:137260]
exact_synonym: "GRP" [HGNC:4605, EntrezGene:2922, UniProt:P07492, MIM:137260]
exact_synonym: "GRP-10" [EntrezGene:2922, UniProt:P07492]
exact_synonym: "Neuromedin-C" [UniProt:P07492]
exact_synonym: "preproGRP" [EntrezGene:2922]
exact_synonym: "proGRP" [EntrezGene:2922]
xref_analog: UniProt:P07492
relationship: sequence_of IMR:0100070 ! gastrin-releasing peptide

[Term]
id: IMR:0002303
name: GRP_RAT
exact_synonym: "gastrin releasing peptide" [RGD:621740]
exact_synonym: "Gastrin-releasing peptide" [UniProt:P24393]
exact_synonym: "GRP" [UniProt:P24393]
exact_synonym: "Grp" [RGD:621740, UniProt:P24393]
exact_synonym: "GRP-10" [UniProt:P24393]
exact_synonym: "Neuromedin-C" [UniProt:P24393]
xref_analog: UniProt:P24393
relationship: sequence_of IMR:0100070 ! gastrin-releasing peptide

[Term]
id: IMR:0002304
name: MOTI_HUMAN
exact_synonym: "MAP" [UniProt:P12872]
exact_synonym: "MGC138519" [EntrezGene:4295]
exact_synonym: "MLN" [MIM:158270, UniProt:P12872, EntrezGene:4295, HGNC:7141]
exact_synonym: "Motilin" [MIM:158270, UniProt:P12872]
exact_synonym: "motilin" [EntrezGene:4295, HGNC:7141]
exact_synonym: "Motilin-associated peptide" [UniProt:P12872]
exact_synonym: "Promotilin" [UniProt:P12872]
xref_analog: UniProt:P12872
relationship: sequence_of IMR:0100051 ! motilin

[Term]
id: IMR:0002305
name: PYY_HUMAN
exact_synonym: "Peptide tyrosine tyrosine" [UniProt:P10082]
exact_synonym: "Peptide YY" [UniProt:P10082]
exact_synonym: "peptide YY" [EntrezGene:5697, HGNC:9748]
exact_synonym: "Peptide YY(3-36)" [UniProt:P10082]
exact_synonym: "PYY" [EntrezGene:5697, HGNC:9748, UniProt:P10082]
exact_synonym: "PYY-I" [UniProt:P10082]
exact_synonym: "PYY-II" [UniProt:P10082]
exact_synonym: "PYY1" [EntrezGene:5697, HGNC:9748]
xref_analog: UniProt:P10082
relationship: sequence_of IMR:0100074 ! peptide YY

[Term]
id: IMR:0002306
name: PYY_MOUSE
exact_synonym: "Peptide tyrosine tyrosine" [UniProt:Q9EPS2]
exact_synonym: "Peptide YY" [UniProt:Q9EPS2]
exact_synonym: "peptide YY" [MGI:99924]
exact_synonym: "Pyy" [MGI:99924, UniProt:Q9EPS2]
exact_synonym: "PYY" [UniProt:Q9EPS2]
xref_analog: UniProt:Q9EPS2
relationship: sequence_of IMR:0100074 ! peptide YY

[Term]
id: IMR:0002307
name: PYY_RAT
exact_synonym: "Peptide tyrosine tyrosine" [UniProt:P10631]
exact_synonym: "Peptide YY" [UniProt:P10631]
exact_synonym: "peptide YY (mapped)" [RGD:1593289]
exact_synonym: "Pyy" [UniProt:P10631, RGD:1593289]
exact_synonym: "PYY" [UniProt:P10631]
xref_analog: UniProt:P10631
relationship: sequence_of IMR:0100074 ! peptide YY

[Term]
id: IMR:0002308
name: SECR_HUMAN
exact_synonym: "SCT" [MIM:182099, UniProt:P09683, EntrezGene:6343, HGNC:10607]
exact_synonym: "Secretin" [MIM:182099, UniProt:P09683]
exact_synonym: "secretin" [EntrezGene:6343, HGNC:10607]
xref_analog: UniProt:P09683
relationship: sequence_of IMR:0100075 ! secretin

[Term]
id: IMR:0002309
name: SECR_MOUSE
exact_synonym: "Sct" [MGI:99466, UniProt:Q08535]
exact_synonym: "Secretin" [UniProt:Q08535]
exact_synonym: "secretin" [MGI:99466]
xref_analog: UniProt:Q08535
relationship: sequence_of IMR:0100075 ! secretin

[Term]
id: IMR:0002310
name: SECR_RAT
exact_synonym: "Sct" [UniProt:P11384, RGD:3643]
exact_synonym: "Secretin" [UniProt:P11384]
exact_synonym: "secretin" [RGD:3643]
xref_analog: UniProt:P11384
relationship: sequence_of IMR:0100075 ! secretin

[Term]
id: IMR:0002311
name: VIP_HUMAN
exact_synonym: "Intestinal peptide PHM-27" [UniProt:P01282]
exact_synonym: "Intestinal peptide PHV-42" [UniProt:P01282]
exact_synonym: "MGC13587" [EntrezGene:7432]
exact_synonym: "Peptide histidine methioninamide 27" [UniProt:P01282]
exact_synonym: "Peptide histidine valine 42" [UniProt:P01282]
exact_synonym: "PHM27" [EntrezGene:7432]
exact_synonym: "Vasoactive intestinal peptide" [MIM:192320, UniProt:P01282]
exact_synonym: "vasoactive intestinal peptide" [EntrezGene:7432, HGNC:12693]
exact_synonym: "Vasoactive intestinal polypeptide" [UniProt:P01282]
exact_synonym: "VIP" [EntrezGene:7432, HGNC:12693, MIM:192320, UniProt:P01282]
exact_synonym: "VIP peptides" [UniProt:P01282]
xref_analog: UniProt:P01282
relationship: sequence_of IMR:0100071 ! vasoactive intestinal peptide

[Term]
id: IMR:0002312
name: VIP_MOUSE
exact_synonym: "Intestinal peptide PHI-27" [UniProt:P32648]
exact_synonym: "Intestinal peptide PHI-42" [UniProt:P32648]
exact_synonym: "Peptide histidine isoleucinamide 27" [UniProt:P32648]
exact_synonym: "PHI, peptide histidine isoleucine" [MGI:98933]
exact_synonym: "Vasoactive intestinal peptide" [UniProt:P32648]
exact_synonym: "Vasoactive intestinal polypeptide" [UniProt:P32648]
exact_synonym: "vasoactive intestinal polypeptide" [MGI:98933]
exact_synonym: "Vip" [UniProt:P32648, MGI:98933]
exact_synonym: "VIP" [UniProt:P32648]
exact_synonym: "VIP peptides" [UniProt:P32648]
xref_analog: UniProt:P32648
relationship: sequence_of IMR:0100071 ! vasoactive intestinal peptide

[Term]
id: IMR:0002313
name: VIP_RAT
exact_synonym: "Intestinal peptide PHI-27" [UniProt:P01283]
exact_synonym: "Intestinal peptide PHV-42" [UniProt:P01283]
exact_synonym: "Peptide histidine isoleucinamide 27" [UniProt:P01283]
exact_synonym: "Vasoactive intestinal peptide" [UniProt:P01283]
exact_synonym: "vasoactive intestinal peptide" [RGD:621647]
exact_synonym: "Vasoactive intestinal polypeptide" [UniProt:P01283]
exact_synonym: "Vip" [UniProt:P01283, RGD:621647]
exact_synonym: "VIP" [UniProt:P01283]
exact_synonym: "VIP peptides" [UniProt:P01283]
xref_analog: UniProt:P01283
relationship: sequence_of IMR:0100071 ! vasoactive intestinal peptide

[Term]
id: IMR:0002314
name: GLUC_HUMAN
exact_synonym: "GCG" [EntrezGene:2641, UniProt:P01275, MIM:138030, HGNC:4191]
exact_synonym: "Glicentin" [UniProt:P01275]
exact_synonym: "Glicentin-related polypeptide" [UniProt:P01275]
exact_synonym: "GLP-1" [UniProt:P01275]
exact_synonym: "GLP-1(7-36)" [UniProt:P01275]
exact_synonym: "GLP-1(7-37)" [UniProt:P01275]
exact_synonym: "GLP-2" [UniProt:P01275]
exact_synonym: "GLP1" [EntrezGene:2641, HGNC:4191]
exact_synonym: "GLP2" [EntrezGene:2641, HGNC:4191]
exact_synonym: "Glucagon" [UniProt:P01275, MIM:138030]
exact_synonym: "glucagon" [EntrezGene:2641, HGNC:4191]
exact_synonym: "Glucagon-like peptide 1" [UniProt:P01275]
exact_synonym: "Glucagon-like peptide 1(7-36)" [UniProt:P01275]
exact_synonym: "Glucagon-like peptide 1(7-37)" [UniProt:P01275]
exact_synonym: "Glucagon-like peptide 2" [UniProt:P01275]
exact_synonym: "GRPP" [EntrezGene:2641, UniProt:P01275, HGNC:4191]
exact_synonym: "OXM" [UniProt:P01275]
exact_synonym: "OXY" [UniProt:P01275]
exact_synonym: "Oxyntomodulin" [UniProt:P01275]
xref_analog: UniProt:P01275
relationship: sequence_of IMR:0100077 ! glucagon

[Term]
id: IMR:0002315
name: GLUC_MOUSE
exact_synonym: "Gcg" [MGI:95674, UniProt:P55095]
exact_synonym: "Glicentin" [UniProt:P55095]
exact_synonym: "Glicentin-related polypeptide" [UniProt:P55095]
exact_synonym: "GLP-1" [MGI:95674, UniProt:P55095]
exact_synonym: "GLP-1(7-36)" [UniProt:P55095]
exact_synonym: "GLP-1(7-37)" [UniProt:P55095]
exact_synonym: "GLP-2" [UniProt:P55095]
exact_synonym: "Glucagon" [UniProt:P55095]
exact_synonym: "glucagon" [MGI:95674]
exact_synonym: "Glucagon-like peptide 1" [UniProt:P55095]
exact_synonym: "Glucagon-like peptide 1(7-36)" [UniProt:P55095]
exact_synonym: "Glucagon-like peptide 1(7-37)" [UniProt:P55095]
exact_synonym: "Glucagon-like peptide 2" [UniProt:P55095]
exact_synonym: "glucagon-like peptide I" [MGI:95674]
exact_synonym: "GRPP" [UniProt:P55095]
exact_synonym: "OXM" [UniProt:P55095]
exact_synonym: "OXY" [UniProt:P55095]
exact_synonym: "Oxyntomodulin" [UniProt:P55095]
xref_analog: UniProt:P55095
relationship: sequence_of IMR:0100077 ! glucagon

[Term]
id: IMR:0002316
name: GLUC_RAT
exact_synonym: "Gcg" [UniProt:P06883, RGD:2668]
exact_synonym: "Glicentin" [UniProt:P06883]
exact_synonym: "Glicentin-related polypeptide" [UniProt:P06883]
exact_synonym: "GLP-1" [UniProt:P06883]
exact_synonym: "GLP-1(7-36)" [UniProt:P06883]
exact_synonym: "GLP-1(7-37)" [UniProt:P06883]
exact_synonym: "GLP-2" [UniProt:P06883]
exact_synonym: "Glucagon" [UniProt:P06883]
exact_synonym: "glucagon" [RGD:2668]
exact_synonym: "Glucagon-like peptide 1" [UniProt:P06883]
exact_synonym: "Glucagon-like peptide 1(7-36)" [UniProt:P06883]
exact_synonym: "Glucagon-like peptide 1(7-37)" [UniProt:P06883]
exact_synonym: "Glucagon-like peptide 2" [UniProt:P06883]
exact_synonym: "GRPP" [UniProt:P06883]
exact_synonym: "OXM" [UniProt:P06883]
exact_synonym: "OXY" [UniProt:P06883]
exact_synonym: "Oxyntomodulin" [UniProt:P06883]
xref_analog: UniProt:P06883
relationship: sequence_of IMR:0100077 ! glucagon

[Term]
id: IMR:0002317
name: PAHO_HUMAN
exact_synonym: "Obinepitide" [UniProt:P01298]
exact_synonym: "Pancreatic hormone" [UniProt:P01298]
exact_synonym: "Pancreatic icosapeptide" [UniProt:P01298]
exact_synonym: "Pancreatic polypeptide" [UniProt:P01298]
exact_synonym: "pancreatic polypeptide" [EntrezGene:5539, HGNC:9327]
exact_synonym: "PANCREATIC POLYPEPTIDE/PANCREATIC ICOSAPEPTIDE" [MIM:167780]
exact_synonym: "Pancreatic prohormone" [UniProt:P01298]
exact_synonym: "PH" [UniProt:P01298]
exact_synonym: "PI" [UniProt:P01298]
exact_synonym: "PNP" [UniProt:P01298, MIM:167780, EntrezGene:5539, HGNC:9327]
exact_synonym: "PP" [UniProt:P01298]
exact_synonym: "PPY" [UniProt:P01298, MIM:167780, EntrezGene:5539, HGNC:9327]
xref_analog: UniProt:P01298
relationship: sequence_of IMR:0100212 ! pancreatic polypeptide

[Term]
id: IMR:0002318
name: PAHO_MOUSE
exact_synonym: "C-terminal peptide" [UniProt:P10601]
exact_synonym: "IGSPP" [MGI:97753]
exact_synonym: "Pancreatic hormone" [UniProt:P10601]
exact_synonym: "Pancreatic polypeptide" [UniProt:P10601]
exact_synonym: "pancreatic polypeptide" [MGI:97753]
exact_synonym: "Pancreatic prohormone" [UniProt:P10601]
exact_synonym: "PH" [UniProt:P10601]
exact_synonym: "PP" [MGI:97753, UniProt:P10601]
exact_synonym: "Ppy" [MGI:97753, UniProt:P10601]
xref_analog: UniProt:P10601
relationship: sequence_of IMR:0100212 ! pancreatic polypeptide

[Term]
id: IMR:0002319
name: PAHO_RAT
exact_synonym: "C-terminal peptide" [UniProt:P06303]
exact_synonym: "Pancreatic hormone" [UniProt:P06303]
exact_synonym: "Pancreatic polypeptide" [UniProt:P06303]
exact_synonym: "pancreatic polypeptide" [RGD:3385]
exact_synonym: "Pancreatic prohormone" [UniProt:P06303]
exact_synonym: "PH" [UniProt:P06303]
exact_synonym: "PP" [UniProt:P06303]
exact_synonym: "Ppy" [RGD:3385, UniProt:P06303]
xref_analog: UniProt:P06303
relationship: sequence_of IMR:0100212 ! pancreatic polypeptide

[Term]
id: IMR:0002320
name: SMS_HUMAN
exact_synonym: "Growth hormone release-inhibiting factor" [UniProt:P61278]
exact_synonym: "SMST" [HGNC:11329, EntrezGene:6750, MIM:182450]
exact_synonym: "Somatostatin" [UniProt:P61278, MIM:182450]
exact_synonym: "somatostatin" [HGNC:11329, EntrezGene:6750]
exact_synonym: "Somatostatin-14" [UniProt:P61278]
exact_synonym: "Somatostatin-28" [UniProt:P61278]
exact_synonym: "SST" [UniProt:P61278, HGNC:11329, EntrezGene:6750, MIM:182450]
xref_analog: UniProt:P61278
relationship: sequence_of IMR:0100213 ! somatostatin

[Term]
id: IMR:0002321
name: SMS_MOUSE
exact_synonym: "Antrin" [UniProt:P60041]
exact_synonym: "preprosomatostatin" [MGI:98326]
exact_synonym: "Smst" [MGI:98326, UniProt:P60041]
exact_synonym: "SOM" [MGI:98326]
exact_synonym: "Somatostatin" [UniProt:P60041]
exact_synonym: "somatostatin" [MGI:98326]
exact_synonym: "Somatostatin-14" [UniProt:P60041]
exact_synonym: "Somatostatin-28" [UniProt:P60041]
exact_synonym: "SRIF" [MGI:98326]
exact_synonym: "Sst" [MGI:98326, UniProt:P60041]
xref_analog: UniProt:P60041
relationship: sequence_of IMR:0100213 ! somatostatin

[Term]
id: IMR:0002322
name: SMS_RAT
exact_synonym: "Antrin" [UniProt:P60042]
exact_synonym: "Smst" [UniProt:P60042]
exact_synonym: "Somatostatin" [UniProt:P60042]
exact_synonym: "somatostatin" [RGD:3761]
exact_synonym: "Somatostatin-14" [UniProt:P60042]
exact_synonym: "Somatostatin-28" [UniProt:P60042]
exact_synonym: "Sst" [RGD:3761, UniProt:P60042]
xref_analog: UniProt:P60042
relationship: sequence_of IMR:0100213 ! somatostatin

[Term]
id: IMR:0002323
name: GLHA_HUMAN
exact_synonym: "Anterior pituitary glycoprotein hormones common subunit alpha" [UniProt:P01215]
exact_synonym: "CG-alpha" [UniProt:P01215]
exact_synonym: "CG-ALPHA" [EntrezGene:1081]
exact_synonym: "CGA" [MIM:118850, HGNC:1885, UniProt:P01215, EntrezGene:1081]
exact_synonym: "Choriogonadotropin alpha chain" [UniProt:P01215]
exact_synonym: "Chorionic gonadotrophin subunit alpha" [UniProt:P01215]
exact_synonym: "CHORIONIC GONADOTROPIN, ALPHA CHAIN" [MIM:118850]
exact_synonym: "Follicle-stimulating hormone alpha chain" [UniProt:P01215]
exact_synonym: "FOLLICLE-STIMULATING HORMONE, ALPHA CHAIN" [MIM:118850]
exact_synonym: "Follitropin alpha chain" [UniProt:P01215]
exact_synonym: "FSH-alpha" [UniProt:P01215]
exact_synonym: "FSHA" [MIM:118850, HGNC:1885, EntrezGene:1081]
exact_synonym: "Glycoprotein hormones alpha chain" [UniProt:P01215]
exact_synonym: "GLYCOPROTEIN HORMONES, ALPHA CHAIN" [MIM:118850]
exact_synonym: "glycoprotein hormones, alpha polypeptide" [HGNC:1885, EntrezGene:1081]
exact_synonym: "GPHa" [HGNC:1885, EntrezGene:1081]
exact_synonym: "GPHA1" [HGNC:1885, EntrezGene:1081]
exact_synonym: "HCG" [HGNC:1885, EntrezGene:1081]
exact_synonym: "LHA" [MIM:118850, HGNC:1885, EntrezGene:1081]
exact_synonym: "LSH-alpha" [UniProt:P01215]
exact_synonym: "Luteinizing hormone alpha chain" [UniProt:P01215]
exact_synonym: "LUTEINIZING HORMONE, ALPHA CHAIN" [MIM:118850]
exact_synonym: "Lutropin alpha chain" [UniProt:P01215]
exact_synonym: "Thyroid-stimulating hormone alpha chain" [UniProt:P01215]
exact_synonym: "THYROID-STIMULATING HORMONE, ALPHA CHAIN" [MIM:118850]
exact_synonym: "Thyrotropin alpha chain" [UniProt:P01215]
exact_synonym: "THYROTROPIN, ALPHA CHAIN" [MIM:118850]
exact_synonym: "TSH-alpha" [UniProt:P01215]
exact_synonym: "TSHA" [MIM:118850, HGNC:1885, EntrezGene:1081]
xref_analog: UniProt:P01215
relationship: sequence_of IMR:0100097 ! glycoprotein hormone, alpha subunit

[Term]
id: IMR:0002324
name: GLHA_MOUSE
exact_synonym: "aGSU" [MGI:88390]
exact_synonym: "alpha-GSU" [MGI:88390]
exact_synonym: "alphaGSU" [MGI:88390]
exact_synonym: "alphaSU" [MGI:88390]
exact_synonym: "Anterior pituitary glycoprotein hormones common subunit alpha" [UniProt:P01216]
exact_synonym: "Cga" [MGI:88390, UniProt:P01216]
exact_synonym: "Follicle-stimulating hormone alpha chain" [UniProt:P01216]
exact_synonym: "Follitropin alpha chain" [UniProt:P01216]
exact_synonym: "FSH-alpha" [UniProt:P01216]
exact_synonym: "Glycoprotein hormones alpha chain" [UniProt:P01216]
exact_synonym: "glycoprotein hormones, alpha subunit" [MGI:88390]
exact_synonym: "GPHalpha" [MGI:88390]
exact_synonym: "LSH-alpha" [UniProt:P01216]
exact_synonym: "Luteinizing hormone alpha chain" [UniProt:P01216]
exact_synonym: "Lutropin alpha chain" [UniProt:P01216]
exact_synonym: "Thyroid-stimulating hormone alpha chain" [UniProt:P01216]
exact_synonym: "Thyrotropin alpha chain" [UniProt:P01216]
exact_synonym: "TSH-alpha" [UniProt:P01216]
exact_synonym: "Tsha" [MGI:88390]
xref_analog: UniProt:P01216
relationship: sequence_of IMR:0100097 ! glycoprotein hormone, alpha subunit

[Term]
id: IMR:0002325
name: GLHA_RAT
exact_synonym: "Anterior pituitary glycoprotein hormones common subunit alpha" [UniProt:P11962]
exact_synonym: "Cga" [UniProt:P11962, RGD:620436]
exact_synonym: "Cga1" [UniProt:P11962]
exact_synonym: "Follicle-stimulating hormone alpha chain" [UniProt:P11962]
exact_synonym: "Follitropin alpha chain" [UniProt:P11962]
exact_synonym: "FSH-alpha" [UniProt:P11962]
exact_synonym: "Glycoprotein hormones alpha chain" [UniProt:P11962]
exact_synonym: "glycoprotein hormones, alpha polypeptide" [RGD:620436]
exact_synonym: "LSH-alpha" [UniProt:P11962]
exact_synonym: "Luteinizing hormone alpha chain" [UniProt:P11962]
exact_synonym: "Lutropin alpha chain" [UniProt:P11962]
exact_synonym: "Thyroid-stimulating hormone alpha chain" [UniProt:P11962]
exact_synonym: "Thyrotropin alpha chain" [UniProt:P11962]
exact_synonym: "TSH-alpha" [UniProt:P11962]
xref_analog: UniProt:P11962
relationship: sequence_of IMR:0100097 ! glycoprotein hormone, alpha subunit

[Term]
id: IMR:0002326
name: TSHB_HUMAN
exact_synonym: "thyroid stimulating hormone, beta" [EntrezGene:7252, HGNC:12372]
exact_synonym: "Thyroid-stimulating hormone subunit beta" [UniProt:P01222]
exact_synonym: "THYROID-STIMULATING HORMONE, BETA CHAIN" [MIM:188540]
exact_synonym: "Thyrotropin alfa" [UniProt:P01222]
exact_synonym: "Thyrotropin beta chain" [UniProt:P01222]
exact_synonym: "Thyrotropin subunit beta" [UniProt:P01222]
exact_synonym: "THYROTROPIN, BETA CHAIN" [MIM:188540]
exact_synonym: "TSH-B" [UniProt:P01222]
exact_synonym: "TSH-beta" [MIM:188540, UniProt:P01222]
exact_synonym: "TSH-BETA" [EntrezGene:7252]
exact_synonym: "TSHB" [MIM:188540, EntrezGene:7252, HGNC:12372, UniProt:P01222]
xref_analog: UniProt:P01222
relationship: sequence_of IMR:0100200 ! thyrotropin

[Term]
id: IMR:0002327
name: TSHB_MOUSE
exact_synonym: "thyroid stimulating hormone, beta subunit" [MGI:98848]
exact_synonym: "Thyroid-stimulating hormone subunit beta" [UniProt:P12656]
exact_synonym: "thyrotropin" [MGI:98848]
exact_synonym: "Thyrotropin beta chain" [UniProt:P12656]
exact_synonym: "Thyrotropin subunit beta" [UniProt:P12656]
exact_synonym: "TSH-B" [UniProt:P12656]
exact_synonym: "TSH-beta" [UniProt:P12656]
exact_synonym: "Tshb" [UniProt:P12656, MGI:98848]
xref_analog: UniProt:P12656
relationship: sequence_of IMR:0100200 ! thyrotropin

[Term]
id: IMR:0002328
name: TSHB_RAT
exact_synonym: "thyroid stimulating hormone, beta" [RGD:3910]
exact_synonym: "Thyroid-stimulating hormone subunit beta" [UniProt:P04652]
exact_synonym: "Thyrotropin beta chain" [UniProt:P04652]
exact_synonym: "Thyrotropin subunit beta" [UniProt:P04652]
exact_synonym: "TSH-B" [UniProt:P04652]
exact_synonym: "TSH-beta" [UniProt:P04652]
exact_synonym: "Tshb" [UniProt:P04652, RGD:3910]
xref_analog: UniProt:P04652
relationship: sequence_of IMR:0100200 ! thyrotropin

[Term]
id: IMR:0002329
name: SOMA_HUMAN
exact_synonym: "GH" [UniProt:P01241, HGNC:4261, MIM:139250, EntrezGene:2688]
exact_synonym: "GH-N" [UniProt:P01241, HGNC:4261, EntrezGene:2688]
exact_synonym: "GH1" [UniProt:P01241, HGNC:4261, MIM:139250, EntrezGene:2688]
exact_synonym: "GHN" [HGNC:4261, MIM:139250, EntrezGene:2688]
exact_synonym: "Growth hormone" [UniProt:P01241]
exact_synonym: "Growth hormone 1" [UniProt:P01241, MIM:139250]
exact_synonym: "growth hormone 1" [HGNC:4261, EntrezGene:2688]
exact_synonym: "GROWTH HORMONE, NORMAL" [MIM:139250]
exact_synonym: "GROWTH HORMONE, PITUITARY" [MIM:139250]
exact_synonym: "hGH-N" [HGNC:4261, EntrezGene:2688]
exact_synonym: "IGHD1B" [EntrezGene:2688]
exact_synonym: "Pituitary growth hormone" [UniProt:P01241]
exact_synonym: "Somatotropin" [UniProt:P01241]
xref_analog: UniProt:P01241
relationship: sequence_of IMR:0100102 ! growth hormone

[Term]
id: IMR:0002330
name: SOMA_MOUSE
exact_synonym: "Gh" [MGI:95707, UniProt:P06880]
exact_synonym: "Gh1" [UniProt:P06880]
exact_synonym: "Growth hormone" [UniProt:P06880]
exact_synonym: "growth hormone" [MGI:95707]
exact_synonym: "Somatotropin" [UniProt:P06880]
xref_analog: UniProt:P06880
relationship: sequence_of IMR:0100102 ! growth hormone

[Term]
id: IMR:0002331
name: SOMA_RAT
exact_synonym: "Gh" [UniProt:P01244]
exact_synonym: "Gh1" [RGD:2686, UniProt:P01244]
exact_synonym: "Growth hormone" [UniProt:P01244]
exact_synonym: "growth hormone 1" [RGD:2686]
exact_synonym: "Somatotropin" [UniProt:P01244]
xref_analog: UniProt:P01244
relationship: sequence_of IMR:0100102 ! growth hormone

[Term]
id: IMR:0002332
name: FSHB_HUMAN
exact_synonym: "follicle stimulating hormone, beta polypeptide" [EntrezGene:2488, HGNC:3964]
exact_synonym: "Follicle-stimulating hormone beta subunit" [UniProt:P01225]
exact_synonym: "FOLLICLE-STIMULATING HORMONE, BETA POLYPEPTIDE" [MIM:136530]
exact_synonym: "Follitropin beta chain" [UniProt:P01225]
exact_synonym: "Follitropin subunit beta" [UniProt:P01225]
exact_synonym: "FOLLITROPIN, BETA CHAIN" [MIM:136530]
exact_synonym: "FSH-B" [UniProt:P01225]
exact_synonym: "FSH-beta" [UniProt:P01225]
exact_synonym: "FSHB" [UniProt:P01225, EntrezGene:2488, HGNC:3964, MIM:136530]
xref_analog: UniProt:P01225
relationship: sequence_of IMR:0100099 ! follicle stimulating hormone

[Term]
id: IMR:0002333
name: FSHB_MOUSE
exact_synonym: "follicle stimulating hormone beta" [MGI:95582]
exact_synonym: "Follicle-stimulating hormone beta subunit" [UniProt:Q60687]
exact_synonym: "Follitropin beta chain" [UniProt:Q60687]
exact_synonym: "Follitropin subunit beta" [UniProt:Q60687]
exact_synonym: "FSH-B" [UniProt:Q60687]
exact_synonym: "FSH-beta" [UniProt:Q60687]
exact_synonym: "Fshb" [UniProt:Q60687, MGI:95582]
exact_synonym: "Fshbeta" [MGI:95582]
xref_analog: UniProt:Q60687
relationship: sequence_of IMR:0100099 ! follicle stimulating hormone

[Term]
id: IMR:0002334
name: FSHB_RAT
exact_synonym: "follicle stimulating hormone, beta polypeptide" [RGD:2630]
exact_synonym: "Follicle-stimulating hormone beta subunit" [UniProt:P18427]
exact_synonym: "Follitropin beta chain" [UniProt:P18427]
exact_synonym: "Follitropin subunit beta" [UniProt:P18427]
exact_synonym: "FSH-B" [UniProt:P18427]
exact_synonym: "FSH-beta" [UniProt:P18427]
exact_synonym: "Fshb" [RGD:2630, UniProt:P18427]
xref_analog: UniProt:P18427
relationship: sequence_of IMR:0100099 ! follicle stimulating hormone

[Term]
id: IMR:0002335
name: LSHB_HUMAN
exact_synonym: "CGB4" [HGNC:6584, EntrezGene:3972]
exact_synonym: "hLHB" [HGNC:6584, EntrezGene:3972]
exact_synonym: "LH-B" [UniProt:P01229]
exact_synonym: "LHB" [UniProt:P01229, HGNC:6584, EntrezGene:3972]
exact_synonym: "LSH-B" [UniProt:P01229, HGNC:6584, EntrezGene:3972]
exact_synonym: "LSH-beta" [UniProt:P01229]
exact_synonym: "luteinizing hormone beta polypeptide" [HGNC:6584, EntrezGene:3972]
exact_synonym: "Luteinizing hormone subunit beta" [UniProt:P01229]
exact_synonym: "Lutropin beta chain" [UniProt:P01229]
exact_synonym: "Lutropin subunit beta" [UniProt:P01229]
xref_analog: UniProt:P01229
relationship: sequence_of IMR:0100100 ! luteinizing hormone

[Term]
id: IMR:0002336
name: LSHB_MOUSE
exact_synonym: "leutropin" [MGI:96782]
exact_synonym: "LH" [MGI:96782]
exact_synonym: "LH-B" [UniProt:O09108]
exact_synonym: "Lhb" [MGI:96782, UniProt:O09108]
exact_synonym: "LSH-B" [UniProt:O09108]
exact_synonym: "LSH-beta" [UniProt:O09108]
exact_synonym: "luteinizing hormone beta" [MGI:96782]
exact_synonym: "Luteinizing hormone subunit beta" [UniProt:O09108]
exact_synonym: "Lutropin beta chain" [UniProt:O09108]
exact_synonym: "Lutropin subunit beta" [UniProt:O09108]
xref_analog: UniProt:O09108
relationship: sequence_of IMR:0100100 ! luteinizing hormone

[Term]
id: IMR:0002337
name: LSHB_RAT
exact_synonym: "LH-B" [UniProt:P01230]
exact_synonym: "Lhb" [RGD:3006, UniProt:P01230]
exact_synonym: "LSH-B" [UniProt:P01230]
exact_synonym: "LSH-beta" [UniProt:P01230]
exact_synonym: "luteinizing hormone beta" [RGD:3006]
exact_synonym: "Luteinizing hormone subunit beta" [UniProt:P01230]
exact_synonym: "Lutropin beta chain" [UniProt:P01230]
exact_synonym: "Lutropin subunit beta" [UniProt:P01230]
xref_analog: UniProt:P01230
relationship: sequence_of IMR:0100100 ! luteinizing hormone

[Term]
id: IMR:0002338
name: CGHB_HUMAN
exact_synonym: "CG-beta" [UniProt:P01233]
exact_synonym: "CG-beta-a" [EntrezGene:94027, HGNC:16451]
exact_synonym: "CGB" [EntrezGene:1082, HGNC:1886, MIM:118860]
exact_synonym: "CGB3" [EntrezGene:1082, HGNC:1886, MIM:118860, UniProt:P01233]
exact_synonym: "CGB5" [EntrezGene:93659, EntrezGene:1082, HGNC:16452, MIM:608825]
exact_synonym: "CGB7" [EntrezGene:1082, EntrezGene:94027, HGNC:16451, MIM:608826]
exact_synonym: "CGB8" [EntrezGene:1082, UniProt:P01233, MIM:608827, HGNC:16453, EntrezGene:94115]
exact_synonym: "Choriogonadotropin subunit beta" [UniProt:P01233]
exact_synonym: "Chorionic gonadotrophin chain beta" [UniProt:P01233]
exact_synonym: "CHORIONIC GONADOTROPIN, BETA CHAIN" [MIM:118860]
exact_synonym: "chorionic gonadotropin, beta polypeptide" [EntrezGene:1082, HGNC:1886]
exact_synonym: "CHORIONIC GONADOTROPIN, BETA POLYPEPTIDE 3" [MIM:118860]
exact_synonym: "chorionic gonadotropin, beta polypeptide 5" [EntrezGene:93659, HGNC:16452, MIM:608825]
exact_synonym: "chorionic gonadotropin, beta polypeptide 7" [EntrezGene:94027, HGNC:16451, MIM:608826]
exact_synonym: "chorionic gonadotropin, beta polypeptide 8" [MIM:608827, HGNC:16453, EntrezGene:94115]
exact_synonym: "FLJ35403" [EntrezGene:94027]
exact_synonym: "FLJ43118" [EntrezGene:94027]
exact_synonym: "HCG" [EntrezGene:93659, HGNC:16452]
exact_synonym: "hCGB" [EntrezGene:1082]
exact_synonym: "MGC119822" [EntrezGene:93659]
xref_analog: UniProt:P01233
relationship: sequence_of IMR:0100106 ! chorionic gonadotropin

[Term]
id: IMR:0002339
name: PRL_HUMAN
exact_synonym: "PRL" [EntrezGene:5617, UniProt:P01236, MIM:176760, HGNC:9445]
exact_synonym: "Prolactin" [UniProt:P01236, MIM:176760]
exact_synonym: "prolactin" [EntrezGene:5617, HGNC:9445]
xref_analog: UniProt:P01236
relationship: sequence_of IMR:0100194 ! prolactin

[Term]
id: IMR:0002340
name: PRL_MOUSE
exact_synonym: "PRL" [UniProt:P06879]
exact_synonym: "Prl" [MGI:97762, UniProt:P06879]
exact_synonym: "Prl1a1" [MGI:97762]
exact_synonym: "Prolactin" [UniProt:P06879]
exact_synonym: "prolactin" [MGI:97762]
xref_analog: UniProt:P06879
relationship: sequence_of IMR:0100194 ! prolactin

[Term]
id: IMR:0002341
name: PRL_RAT
exact_synonym: "PRL" [UniProt:P01237]
exact_synonym: "Prl" [UniProt:P01237, RGD:3403]
exact_synonym: "Prolactin" [UniProt:P01237]
exact_synonym: "prolactin" [RGD:3403]
xref_analog: UniProt:P01237
relationship: sequence_of IMR:0100194 ! prolactin

[Term]
id: IMR:0002342
name: COLI_HUMAN
exact_synonym: "ACTH" [HGNC:9201, EntrezGene:5443, UniProt:P01189]
exact_synonym: "Adrenocorticotropic hormone" [UniProt:P01189]
exact_synonym: "Alpha-MSH" [UniProt:P01189]
exact_synonym: "Beta-endorphin" [UniProt:P01189]
exact_synonym: "Beta-LPH" [UniProt:P01189]
exact_synonym: "Beta-MSH" [UniProt:P01189]
exact_synonym: "CLIP" [HGNC:9201, EntrezGene:5443, UniProt:P01189]
exact_synonym: "Corticotropin" [UniProt:P01189]
exact_synonym: "Corticotropin-like intermediary peptide" [UniProt:P01189]
exact_synonym: "Corticotropin-lipotropin" [UniProt:P01189]
exact_synonym: "Gamma-LPH" [UniProt:P01189]
exact_synonym: "Gamma-MSH" [UniProt:P01189]
exact_synonym: "Lipotropin beta" [UniProt:P01189]
exact_synonym: "Lipotropin gamma" [UniProt:P01189]
exact_synonym: "LPH" [HGNC:9201, EntrezGene:5443]
exact_synonym: "Melanotropin alpha" [UniProt:P01189]
exact_synonym: "Melanotropin beta" [UniProt:P01189]
exact_synonym: "Melanotropin gamma" [UniProt:P01189]
exact_synonym: "Met-enkephalin" [UniProt:P01189]
exact_synonym: "MSH" [HGNC:9201, EntrezGene:5443]
exact_synonym: "NPP" [HGNC:9201, EntrezGene:5443, UniProt:P01189]
exact_synonym: "POC" [HGNC:9201, EntrezGene:5443, MIM:176830]
exact_synonym: "POMC" [HGNC:9201, EntrezGene:5443, MIM:176830, UniProt:P01189]
exact_synonym: "Potential peptide" [UniProt:P01189]
exact_synonym: "PRO-ACTH-ENDORPHIN" [MIM:176830]
exact_synonym: "Pro-opiomelanocortin" [UniProt:P01189]
exact_synonym: "proopiomelanocortin" [HGNC:9201, EntrezGene:5443, MIM:176830]
xref_analog: UniProt:P01189
relationship: sequence_of IMR:0002345 ! beta lipotropin
relationship: sequence_of IMR:0002346 ! gamma lipotropin
relationship: sequence_of IMR:0100064 ! beta-MSH
relationship: sequence_of IMR:0100195 ! corticotropin
relationship: sequence_of IMR:0100196 ! alpha-MSH
relationship: sequence_of IMR:0100199 ! gamma-MSH

[Term]
id: IMR:0002343
name: COLI_MOUSE
exact_synonym: "ACTH" [MGI:97742, UniProt:P01193]
exact_synonym: "adrenal corticotropic hormone" [MGI:97742]
exact_synonym: "Adrenocorticotropic hormone" [UniProt:P01193]
exact_synonym: "alpha-melanocyte stimulating hormone" [MGI:97742]
exact_synonym: "Alpha-MSH" [UniProt:P01193]
exact_synonym: "alpha-MSH" [MGI:97742]
exact_synonym: "alphaMSH" [MGI:97742]
exact_synonym: "BE" [MGI:97742]
exact_synonym: "Beta-endorphin" [UniProt:P01193]
exact_synonym: "beta-endorphin" [MGI:97742]
exact_synonym: "Beta-LPH" [UniProt:P01193]
exact_synonym: "beta-melanocyte stimulating hormone" [MGI:97742]
exact_synonym: "Beta-MSH" [UniProt:P01193]
exact_synonym: "beta-MSH" [MGI:97742]
exact_synonym: "CLIP" [UniProt:P01193]
exact_synonym: "Corticotropin" [UniProt:P01193]
exact_synonym: "Corticotropin-like intermediary peptide" [UniProt:P01193]
exact_synonym: "Corticotropin-lipotropin" [UniProt:P01193]
exact_synonym: "Gamma-LPH" [UniProt:P01193]
exact_synonym: "gamma-melanocyte stimulating hormone" [MGI:97742]
exact_synonym: "Gamma-MSH" [UniProt:P01193]
exact_synonym: "gamma-MSH" [MGI:97742]
exact_synonym: "Lipotropin beta" [UniProt:P01193]
exact_synonym: "Lipotropin gamma" [UniProt:P01193]
exact_synonym: "Melanotropin alpha" [UniProt:P01193]
exact_synonym: "Melanotropin beta" [UniProt:P01193]
exact_synonym: "Melanotropin gamma" [UniProt:P01193]
exact_synonym: "Met-enkephalin" [UniProt:P01193]
exact_synonym: "NPP" [UniProt:P01193]
exact_synonym: "POMC" [MGI:97742, UniProt:P01193]
exact_synonym: "Pomc" [MGI:97742, UniProt:P01193]
exact_synonym: "Pomc-1" [MGI:97742]
exact_synonym: "Pomc1" [UniProt:P01193]
exact_synonym: "Pro-opiomelanocortin" [UniProt:P01193]
exact_synonym: "pro-opiomelanocortin-alpha" [MGI:97742]
xref_analog: UniProt:P01193
relationship: sequence_of IMR:0002345 ! beta lipotropin
relationship: sequence_of IMR:0002346 ! gamma lipotropin
relationship: sequence_of IMR:0100064 ! beta-MSH
relationship: sequence_of IMR:0100195 ! corticotropin
relationship: sequence_of IMR:0100196 ! alpha-MSH
relationship: sequence_of IMR:0100199 ! gamma-MSH

[Term]
id: IMR:0002344
name: COLI_RAT
exact_synonym: "ACTH" [UniProt:P01194]
exact_synonym: "Adrenocorticotropic hormone" [UniProt:P01194]
exact_synonym: "Alpha-MSH" [UniProt:P01194]
exact_synonym: "Beta-endorphin" [UniProt:P01194]
exact_synonym: "Beta-LPH" [UniProt:P01194]
exact_synonym: "Beta-MSH" [UniProt:P01194]
exact_synonym: "CLIP" [UniProt:P01194]
exact_synonym: "Corticotropin" [UniProt:P01194]
exact_synonym: "Corticotropin-like intermediary peptide" [UniProt:P01194]
exact_synonym: "Corticotropin-lipotropin" [UniProt:P01194]
exact_synonym: "Gamma-LPH" [UniProt:P01194]
exact_synonym: "Gamma-MSH" [UniProt:P01194]
exact_synonym: "Lipotropin beta" [UniProt:P01194]
exact_synonym: "Lipotropin gamma" [UniProt:P01194]
exact_synonym: "Melanotropin alpha" [UniProt:P01194]
exact_synonym: "Melanotropin beta" [UniProt:P01194]
exact_synonym: "Melanotropin gamma" [UniProt:P01194]
exact_synonym: "Met-enkephalin" [UniProt:P01194]
exact_synonym: "NPP" [UniProt:P01194]
exact_synonym: "POMC" [UniProt:P01194]
exact_synonym: "Pomc" [RGD:3366, UniProt:P01194]
exact_synonym: "Pomc2" [UniProt:P01194]
exact_synonym: "Pro-opiomelanocortin" [UniProt:P01194]
exact_synonym: "proopiomelanocortin" [RGD:3366]
xref_analog: UniProt:P01194
relationship: sequence_of IMR:0002345 ! beta lipotropin
relationship: sequence_of IMR:0002346 ! gamma lipotropin
relationship: sequence_of IMR:0100064 ! beta-MSH
relationship: sequence_of IMR:0100195 ! corticotropin
relationship: sequence_of IMR:0100196 ! alpha-MSH
relationship: sequence_of IMR:0100199 ! gamma-MSH

[Term]
id: IMR:0002345
name: beta lipotropin
exact_synonym: "beta-LPH" []
is_a: IMR:0100197 ! lipotropin

[Term]
id: IMR:0002346
name: gamma lipotropin
exact_synonym: "gamma-LPH" []
is_a: IMR:0100197 ! lipotropin

[Term]
id: IMR:0002347
name: GON1_HUMAN
exact_synonym: "GNRH" [MIM:152760, EntrezGene:2796, UniProt:P01148]
exact_synonym: "GnRH-associated peptide 1" [UniProt:P01148]
exact_synonym: "GnRH-associated peptide I" [UniProt:P01148]
exact_synonym: "GnRH-I" [UniProt:P01148]
exact_synonym: "GNRH1" [MIM:152760, EntrezGene:2796, UniProt:P01148, HGNC:4419]
exact_synonym: "Gonadoliberin I" [UniProt:P01148]
exact_synonym: "Gonadoliberin-1" [UniProt:P01148]
exact_synonym: "Gonadorelin" [UniProt:P01148]
exact_synonym: "GONADOTROPIN-RELEASING HORMONE 1" [MIM:152760]
exact_synonym: "gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)" [EntrezGene:2796, HGNC:4419]
exact_synonym: "Gonadotropin-releasing hormone I" [UniProt:P01148]
exact_synonym: "GRH" [EntrezGene:2796, UniProt:P01148]
exact_synonym: "LH-RH I" [UniProt:P01148]
exact_synonym: "LHRH" [MIM:152760, EntrezGene:2796, UniProt:P01148]
exact_synonym: "LNRH" [EntrezGene:2796]
exact_synonym: "Luliberin I" [UniProt:P01148]
exact_synonym: "LUTEINIZING HORMONE-RELEASING HORMONE" [MIM:152760]
exact_synonym: "Luteinizing hormone-releasing hormone I" [UniProt:P01148]
exact_synonym: "Progonadoliberin I" [UniProt:P01148]
exact_synonym: "Progonadoliberin-1" [UniProt:P01148]
xref_analog: UniProt:P01148
relationship: sequence_of IMR:0100092 ! prolactin release-inhibiting hormone
relationship: sequence_of IMR:0100095 ! gonadotropin-releasing hormone

[Term]
id: IMR:0002348
name: GON1_MOUSE
exact_synonym: "Gnrh" [UniProt:P13562]
exact_synonym: "GnRH-I" [UniProt:P13562]
exact_synonym: "Gnrh1" [UniProt:P13562, MGI:95789]
exact_synonym: "Gonadoliberin I" [UniProt:P13562]
exact_synonym: "Gonadoliberin-1" [UniProt:P13562]
exact_synonym: "gonadotropin releasing hormone 1" [MGI:95789]
exact_synonym: "Gonadotropin-releasing hormone I" [UniProt:P13562]
exact_synonym: "LH-RH I" [UniProt:P13562]
exact_synonym: "LHRH" [MGI:95789]
exact_synonym: "LNRH" [MGI:95789]
exact_synonym: "Luliberin I" [UniProt:P13562]
exact_synonym: "Luteinizing hormone-releasing hormone I" [UniProt:P13562]
exact_synonym: "Progonadoliberin I" [UniProt:P13562]
exact_synonym: "Progonadoliberin-1" [UniProt:P13562]
exact_synonym: "Prolactin release-inhibiting factor 1" [UniProt:P13562]
exact_synonym: "Prolactin release-inhibiting factor I" [UniProt:P13562]
xref_analog: UniProt:P13562
relationship: sequence_of IMR:0100092 ! prolactin release-inhibiting hormone
relationship: sequence_of IMR:0100095 ! gonadotropin-releasing hormone

[Term]
id: IMR:0002349
name: GON1_RAT
exact_synonym: "Gnrh" [UniProt:P07490]
exact_synonym: "GnRH-I" [UniProt:P07490]
exact_synonym: "Gnrh1" [RGD:2720, UniProt:P07490]
exact_synonym: "Gonadoliberin I" [UniProt:P07490]
exact_synonym: "Gonadoliberin-1" [UniProt:P07490]
exact_synonym: "gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)" [RGD:2720]
exact_synonym: "Gonadotropin-releasing hormone I" [UniProt:P07490]
exact_synonym: "LH-RH I" [UniProt:P07490]
exact_synonym: "Luliberin I" [UniProt:P07490]
exact_synonym: "Luteinizing hormone-releasing hormone I" [UniProt:P07490]
exact_synonym: "Progonadoliberin I" [UniProt:P07490]
exact_synonym: "Progonadoliberin-1" [UniProt:P07490]
exact_synonym: "Prolactin release-inhibiting factor 1" [UniProt:P07490]
exact_synonym: "Prolactin release-inhibiting factor I" [UniProt:P07490]
xref_analog: UniProt:P07490
relationship: sequence_of IMR:0100092 ! prolactin release-inhibiting hormone
relationship: sequence_of IMR:0100095 ! gonadotropin-releasing hormone

[Term]
id: IMR:0002350
name: CRF_HUMAN
exact_synonym: "Corticoliberin" [UniProt:P06850]
exact_synonym: "corticotropin releasing hormone" [EntrezGene:1392, HGNC:2355]
exact_synonym: "Corticotropin-releasing factor" [UniProt:P06850, MIM:122560]
exact_synonym: "Corticotropin-releasing hormone" [UniProt:P06850, MIM:122560]
exact_synonym: "CRF" [UniProt:P06850, EntrezGene:1392, MIM:122560, HGNC:2355]
exact_synonym: "CRH" [UniProt:P06850, EntrezGene:1392, MIM:122560, HGNC:2355]
xref_analog: UniProt:P06850
relationship: sequence_of IMR:0100094 ! corticotropin-releasing hormone

[Term]
id: IMR:0002351
name: CRF_MOUSE
exact_synonym: "Corticoliberin" [UniProt:Q8CIT0]
exact_synonym: "corticotropin releasing factor" [MGI:88496]
exact_synonym: "corticotropin releasing hormone" [MGI:88496]
exact_synonym: "Corticotropin-releasing factor" [UniProt:Q8CIT0]
exact_synonym: "corticotropin-releasing factor" [MGI:88496]
exact_synonym: "Corticotropin-releasing hormone" [UniProt:Q8CIT0]
exact_synonym: "CRF" [MGI:88496, UniProt:Q8CIT0]
exact_synonym: "Crh" [MGI:88496, UniProt:Q8CIT0]
exact_synonym: "Gm1347" [UniProt:Q8CIT0]
exact_synonym: "LOC383938" [MGI:88496]
xref_analog: UniProt:Q8CIT0
relationship: sequence_of IMR:0100094 ! corticotropin-releasing hormone

[Term]
id: IMR:0002352
name: CRF_RAT
exact_synonym: "Corticoliberin" [UniProt:P01143]
exact_synonym: "corticotropin releasing hormone" [RGD:620505]
exact_synonym: "Corticotropin-releasing factor" [UniProt:P01143]
exact_synonym: "Corticotropin-releasing hormone" [UniProt:P01143]
exact_synonym: "CRF" [UniProt:P01143]
exact_synonym: "Crh" [RGD:620505, UniProt:P01143]
xref_analog: UniProt:P01143
relationship: sequence_of IMR:0100094 ! corticotropin-releasing hormone

[Term]
id: IMR:0002353
name: PRRP_HUMAN
exact_synonym: "PRH" [HGNC:17945, UniProt:P81277, MIM:602663, EntrezGene:51052]
exact_synonym: "PRLH" [HGNC:17945, UniProt:P81277, MIM:602663, EntrezGene:51052]
exact_synonym: "prolactin releasing hormone" [HGNC:17945, EntrezGene:51052]
exact_synonym: "Prolactin-releasing hormone" [UniProt:P81277, MIM:602663]
exact_synonym: "Prolactin-releasing peptide" [UniProt:P81277, MIM:602663]
exact_synonym: "Prolactin-releasing peptide PrRP20" [UniProt:P81277]
exact_synonym: "Prolactin-releasing peptide PrRP31" [UniProt:P81277]
exact_synonym: "PrRP" [UniProt:P81277, MIM:602663]
exact_synonym: "PRRP" [EntrezGene:51052]
xref_analog: UniProt:P81277
relationship: sequence_of IMR:0100055 ! prolactin-releasing hormone

[Term]
id: IMR:0002354
name: PRRP_RAT
exact_synonym: "Prh" [UniProt:P81278]
exact_synonym: "Prlh" [UniProt:P81278, RGD:628634]
exact_synonym: "prolactin releasing hormone" [RGD:628634]
exact_synonym: "Prolactin-releasing hormone" [UniProt:P81278]
exact_synonym: "Prolactin-releasing peptide" [UniProt:P81278]
exact_synonym: "Prolactin-releasing peptide PrRP20" [UniProt:P81278]
exact_synonym: "Prolactin-releasing peptide PrRP31" [UniProt:P81278]
exact_synonym: "PrRP" [UniProt:P81278]
xref_analog: UniProt:P81278
relationship: sequence_of IMR:0100055 ! prolactin-releasing hormone

[Term]
id: IMR:0002355
name: TRH_HUMAN
exact_synonym: "MGC125964" [EntrezGene:7200]
exact_synonym: "MGC125965" [EntrezGene:7200]
exact_synonym: "Prothyroliberin" [UniProt:P20396]
exact_synonym: "Protirelin" [UniProt:P20396]
exact_synonym: "Thyroliberin" [UniProt:P20396]
exact_synonym: "Thyrotropin-releasing factor" [UniProt:P20396]
exact_synonym: "Thyrotropin-releasing hormone" [UniProt:P20396]
exact_synonym: "thyrotropin-releasing hormone" [HGNC:12298, EntrezGene:7200]
exact_synonym: "TRF" [UniProt:P20396]
exact_synonym: "TRH" [HGNC:12298, EntrezGene:7200, UniProt:P20396]
exact_synonym: "TSH-releasing factor" [UniProt:P20396]
xref_analog: UniProt:P20396
relationship: sequence_of IMR:0100056 ! thyrotropin-releasing hormone

[Term]
id: IMR:0002356
name: TRH_MOUSE
exact_synonym: "Prothyroliberin" [UniProt:Q62361]
exact_synonym: "Protirelin" [UniProt:Q62361]
exact_synonym: "Thyroliberin" [UniProt:Q62361]
exact_synonym: "thyrotropin releasing hormone" [MGI:98823]
exact_synonym: "Thyrotropin-releasing factor" [UniProt:Q62361]
exact_synonym: "Thyrotropin-releasing hormone" [UniProt:Q62361]
exact_synonym: "TRF" [UniProt:Q62361]
exact_synonym: "TRH" [UniProt:Q62361]
exact_synonym: "Trh" [MGI:98823, UniProt:Q62361]
exact_synonym: "TSH-releasing factor" [UniProt:Q62361]
xref_analog: UniProt:Q62361
relationship: sequence_of IMR:0100056 ! thyrotropin-releasing hormone

[Term]
id: IMR:0002357
name: TRH_RAT
exact_synonym: "Prothyroliberin" [UniProt:P01150]
exact_synonym: "Protirelin" [UniProt:P01150]
exact_synonym: "Thyroliberin" [UniProt:P01150]
exact_synonym: "thyrotropin releasing hormone" [RGD:3903]
exact_synonym: "Thyrotropin-releasing factor" [UniProt:P01150]
exact_synonym: "Thyrotropin-releasing hormone" [UniProt:P01150]
exact_synonym: "TRF" [UniProt:P01150]
exact_synonym: "TRH" [UniProt:P01150]
exact_synonym: "Trh" [UniProt:P01150, RGD:3903]
exact_synonym: "TSH-releasing factor" [UniProt:P01150]
xref_analog: UniProt:P01150
relationship: sequence_of IMR:0100056 ! thyrotropin-releasing hormone

[Term]
id: IMR:0002358
name: SLIB_HUMAN
exact_synonym: "GHRF" [EntrezGene:2691, UniProt:P01286, MIM:139190]
exact_synonym: "GHRH" [EntrezGene:2691, HGNC:4265, UniProt:P01286, MIM:139190]
exact_synonym: "GRF" [EntrezGene:2691, UniProt:P01286]
exact_synonym: "growth hormone releasing hormone" [EntrezGene:2691, HGNC:4265]
exact_synonym: "Growth hormone-releasing factor" [UniProt:P01286, MIM:139190]
exact_synonym: "Growth hormone-releasing hormone" [UniProt:P01286, MIM:139190]
exact_synonym: "INN" [EntrezGene:2691]
exact_synonym: "MGC119781" [EntrezGene:2691]
exact_synonym: "Sermorelin" [UniProt:P01286]
exact_synonym: "Somatocrinin" [UniProt:P01286, MIM:139190]
exact_synonym: "Somatoliberin" [UniProt:P01286]
exact_synonym: "Somatorelin" [UniProt:P01286]
xref_analog: UniProt:P01286
relationship: sequence_of IMR:0100057 ! growth hormone-releasing hormone

[Term]
id: IMR:0002359
name: SLIB_MOUSE
exact_synonym: "Ghrf" [MGI:95709]
exact_synonym: "Ghrh" [MGI:95709, UniProt:P16043]
exact_synonym: "GHRH" [UniProt:P16043]
exact_synonym: "GRF" [UniProt:P16043]
exact_synonym: "growth hormone releasing hormone" [MGI:95709]
exact_synonym: "Growth hormone-releasing factor" [UniProt:P16043]
exact_synonym: "Growth hormone-releasing hormone" [UniProt:P16043]
exact_synonym: "Somatoliberin" [UniProt:P16043]
xref_analog: UniProt:P16043
relationship: sequence_of IMR:0100057 ! growth hormone-releasing hormone

[Term]
id: IMR:0002360
name: SLIB_RAT
exact_synonym: "Ghrh" [UniProt:P09916, RGD:61883]
exact_synonym: "GHRH" [UniProt:P09916]
exact_synonym: "GRF" [UniProt:P09916]
exact_synonym: "growth hormone releasing hormone" [RGD:61883]
exact_synonym: "Growth hormone-releasing factor" [UniProt:P09916]
exact_synonym: "Growth hormone-releasing hormone" [UniProt:P09916]
exact_synonym: "Somatoliberin" [UniProt:P09916]
xref_analog: UniProt:P09916
relationship: sequence_of IMR:0100057 ! growth hormone-releasing hormone

[Term]
id: IMR:0002361
name: CSH_HUMAN
exact_synonym: "Choriomammotropin" [UniProt:P01243]
exact_synonym: "CHORIONIC SOMATOMAMMOTROPIN A" [MIM:150200]
exact_synonym: "CHORIONIC SOMATOMAMMOTROPIN B" [MIM:118820]
exact_synonym: "Chorionic somatomammotropin hormone" [UniProt:P01243]
exact_synonym: "CHORIONIC SOMATOMAMMOTROPIN HORMONE 1" [MIM:150200]
exact_synonym: "chorionic somatomammotropin hormone 1 (placental lactogen)" [EntrezGene:1442, HGNC:2440]
exact_synonym: "chorionic somatomammotropin hormone 2" [HGNC:2441, EntrezGene:1443, MIM:118820]
exact_synonym: "CS-2" [HGNC:2441, EntrezGene:1443]
exact_synonym: "CSA" [EntrezGene:1442, MIM:150200, HGNC:2440]
exact_synonym: "CSB" [HGNC:2441, EntrezGene:1443, MIM:118820]
exact_synonym: "CSH1" [EntrezGene:1442, MIM:150200, HGNC:2440]
exact_synonym: "CSH2" [UniProt:P01243, EntrezGene:1442, HGNC:2441, EntrezGene:1443, MIM:118820]
exact_synonym: "CSMT" [EntrezGene:1442, MIM:150200, HGNC:2440]
exact_synonym: "FLJ75407" [EntrezGene:1442, HGNC:2440]
exact_synonym: "hCS-A" [HGNC:2440]
exact_synonym: "hCS-B" [HGNC:2441, EntrezGene:1443]
exact_synonym: "Lactogen" [UniProt:P01243]
exact_synonym: "LACTOGEN, PLACENTAL" [MIM:150200]
exact_synonym: "PL" [UniProt:P01243, EntrezGene:1442, MIM:150200, HGNC:2440]
exact_synonym: "Placental lactogen" [UniProt:P01243]
xref_analog: UniProt:P01243
relationship: sequence_of IMR:0100105 ! placental lactogen

[Term]
id: IMR:0002362
name: PR3D1_MOUSE
exact_synonym: "Chorionic somatomammotropin hormone 1" [UniProt:P18121]
exact_synonym: "Csh1" [MGI:97606, UniProt:P18121]
exact_synonym: "mPL-I" [MGI:97606]
exact_synonym: "Pl-1" [MGI:97606, UniProt:P18121]
exact_synonym: "PL-I" [UniProt:P18121]
exact_synonym: "PL-Ia" [MGI:97606]
exact_synonym: "Pl1" [MGI:97606, UniProt:P18121]
exact_synonym: "placental lactogen 1" [MGI:97606]
exact_synonym: "Placental lactogen I" [UniProt:P18121]
exact_synonym: "Prl3d1" [MGI:97606, UniProt:P18121]
exact_synonym: "prolactin family 3, subfamily d, member 1" [MGI:97606]
exact_synonym: "Prolactin-3D1" [UniProt:P18121]
exact_synonym: "prolactin-like 2" [MGI:97606]
xref_analog: UniProt:P18121
relationship: sequence_of IMR:0100105 ! placental lactogen

[Term]
id: IMR:0002363
name: PR3D1_RAT
exact_synonym: "Chorionic somatomammotropin hormone 1" [UniProt:P21702]
exact_synonym: "Csh1" [UniProt:P21702]
exact_synonym: "PL-I" [UniProt:P21702]
exact_synonym: "Pl1" [UniProt:P21702]
exact_synonym: "Placental lactogen I" [UniProt:P21702]
exact_synonym: "Prl3d1" [UniProt:P21702, RGD:2427]
exact_synonym: "Prolactin family 3, subfamily d, member 1" [RGD:2427]
exact_synonym: "Prolactin-3D1" [UniProt:P21702]
xref_analog: UniProt:P21702
relationship: sequence_of IMR:0100105 ! placental lactogen

[Term]
id: IMR:0002364
name: PR3B1_MOUSE
exact_synonym: "Chorionic somatomammotropin hormone 2" [UniProt:P09586]
exact_synonym: "Csh2" [UniProt:P09586, MGI:97607]
exact_synonym: "mPL-II" [MGI:97607]
exact_synonym: "mplII" [MGI:97607]
exact_synonym: "PL" [MGI:97607]
exact_synonym: "Pl-2" [UniProt:P09586, MGI:97607]
exact_synonym: "PL-II" [UniProt:P09586]
exact_synonym: "Pl2" [UniProt:P09586, MGI:97607]
exact_synonym: "Placental lactogen II" [UniProt:P09586]
exact_synonym: "Prl3b1" [UniProt:P09586, MGI:97607]
exact_synonym: "prolactin family 3, subfamily b, member 1" [MGI:97607]
exact_synonym: "Prolactin-3B1" [UniProt:P09586]
exact_synonym: "prolactin-like" [MGI:97607]
xref_analog: UniProt:P09586
relationship: sequence_of IMR:0100105 ! placental lactogen

[Term]
id: IMR:0002365
name: PR3B1_RAT
exact_synonym: "Chorionic somatomammotropin hormone 2" [UniProt:P09321]
exact_synonym: "Csh2" [UniProt:P09321]
exact_synonym: "PL-II" [UniProt:P09321]
exact_synonym: "Pl2" [UniProt:P09321]
exact_synonym: "Placental lactogen II" [UniProt:P09321]
exact_synonym: "Prl3b1" [RGD:2429, UniProt:P09321]
exact_synonym: "Prolactin family 3, subfamily b, member 1" [RGD:2429]
exact_synonym: "Prolactin-3B1" [UniProt:P09321]
exact_synonym: "RPLII" [UniProt:P09321]
xref_analog: UniProt:P09321
relationship: sequence_of IMR:0100105 ! placental lactogen

[Term]
id: IMR:0002366
name: VpreB
relationship: part_of IMR:0002097 ! pre-BCR

[Term]
id: IMR:0002367
name: lambda 5
relationship: part_of IMR:0002097 ! pre-BCR

[Term]
id: IMR:0002368
name: VPREB_HUMAN
exact_synonym: "CD179 antigen-like family member A" [UniProt:P12018]
exact_synonym: "CD179a" [UniProt:P12018]
exact_synonym: "CD179A" [HGNC:12709]
exact_synonym: "IGI" [MIM:605141]
exact_synonym: "IGVPB" [MIM:605141]
exact_synonym: "Immunoglobulin iota chain" [UniProt:P12018]
exact_synonym: "IMMUNOGLOBULIN IOTA POLYPEPTIDE CHAIN" [MIM:605141]
exact_synonym: "pre-B lymphocyte 1" [HGNC:12709]
exact_synonym: "PRE-B-LYMPHOCYTE GENE 1" [MIM:605141]
exact_synonym: "Protein VPreB1" [UniProt:P12018]
exact_synonym: "V(pre)B protein" [UniProt:P12018]
exact_synonym: "VPREB" [MIM:605141, UniProt:P12018]
exact_synonym: "VpreB" [HGNC:12709]
exact_synonym: "VpreB protein" [UniProt:P12018]
exact_synonym: "VPREB1" [MIM:605141, HGNC:12709, UniProt:P12018]
xref_analog: UniProt:P12018
relationship: sequence_of IMR:0002366 ! VpreB

[Term]
id: IMR:0002369
name: VPRE1_MOUSE
exact_synonym: "CD179a" [MGI:98936, UniProt:P13372]
exact_synonym: "Immunoglobulin iota chain" [UniProt:P13372]
exact_synonym: "pre-B lymphocyte gene 1" [MGI:98936]
exact_synonym: "Protein VPreB1" [UniProt:P13372]
exact_synonym: "Vpreb-1" [MGI:98936]
exact_synonym: "Vpreb1" [MGI:98936, UniProt:P13372]
xref_analog: UniProt:P13372
relationship: sequence_of IMR:0002366 ! VpreB

[Term]
id: IMR:0002370
name: IGLL1_HUMAN
exact_synonym: "14.1" [EntrezGene:3543, HGNC:5870]
exact_synonym: "AGM2" [EntrezGene:3543]
exact_synonym: "CD179 antigen-like family member B" [UniProt:P15814]
exact_synonym: "CD179b" [EntrezGene:3543, UniProt:P15814]
exact_synonym: "CD179B" [HGNC:5870]
exact_synonym: "Ig lambda-5" [UniProt:P15814]
exact_synonym: "IGL1" [EntrezGene:3543, UniProt:P15814]
exact_synonym: "IGL5" [EntrezGene:3543, HGNC:5870]
exact_synonym: "IGL5, MOUSE, HOMOLOG OF" [MIM:146770]
exact_synonym: "IGLJ14.1" [EntrezGene:3543]
exact_synonym: "IGLL" [MIM:146770, EntrezGene:3543]
exact_synonym: "IGLL1" [MIM:146770, EntrezGene:3543, UniProt:P15814, HGNC:5870]
exact_synonym: "IGO" [MIM:146770, EntrezGene:3543]
exact_synonym: "IGVPB" [EntrezGene:3543, HGNC:5870]
exact_synonym: "Immunoglobulin lambda-like polypeptide 1" [MIM:146770, UniProt:P15814]
exact_synonym: "immunoglobulin lambda-like polypeptide 1" [EntrezGene:3543, HGNC:5870]
exact_synonym: "Immunoglobulin omega polypeptide" [UniProt:P15814]
exact_synonym: "IMMUNOGLOBULIN OMEGA POLYPEPTIDE CHAIN" [MIM:146770]
exact_synonym: "Immunoglobulin-related protein 14.1" [UniProt:P15814]
exact_synonym: "LAMBDA-5, MOUSE, HOMOLOG OF" [MIM:146770]
exact_synonym: "VPREB2" [EntrezGene:3543]
xref_analog: UniProt:P15814
relationship: sequence_of IMR:0002367 ! lambda 5

[Term]
id: IMR:0002371
name: IGLL1_MOUSE
exact_synonym: "CD179 antigen-like family member B" [UniProt:P20764]
exact_synonym: "CD179b" [UniProt:P20764]
exact_synonym: "Ig lambda-5" [UniProt:P20764]
exact_synonym: "Igl-5" [UniProt:P20764, MGI:96529]
exact_synonym: "Igll" [MGI:96529]
exact_synonym: "Igll1" [UniProt:P20764, MGI:96529]
exact_synonym: "Immunoglobulin lambda-like polypeptide 1" [UniProt:P20764]
exact_synonym: "immunoglobulin lambda-like polypeptide 1" [MGI:96529]
exact_synonym: "Lambda 5" [MGI:96529]
xref_analog: UniProt:P20764
relationship: sequence_of IMR:0002367 ! lambda 5

[Term]
id: IMR:0002372
name: TCR-CD3 complex
exact_synonym: "T cell receptor-CD3 complex" []
xref_analog: GO:0042101
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0002373
name: TCA_HUMAN
exact_synonym: "T cell receptor alpha constant" [EntrezGene:28755, HGNC:12029]
exact_synonym: "T-cell receptor alpha chain C region" [UniProt:P01848]
exact_synonym: "TCRA" [EntrezGene:28755, UniProt:P01848]
exact_synonym: "TRAC" [EntrezGene:28755, HGNC:12029, UniProt:P01848]
xref_analog: UniProt:P01848
relationship: sequence_of IMR:0100350 ! TCR alpha

[Term]
id: IMR:0002374
name: TCA_MOUSE
exact_synonym: "T-cell receptor alpha chain" [MGI:98553]
exact_synonym: "T-cell receptor alpha chain C region" [UniProt:P01849]
exact_synonym: "Tcr alpha" [MGI:98553]
exact_synonym: "Tcra" [UniProt:P01849, MGI:98553]
exact_synonym: "Tcralpha" [MGI:98553]
xref_analog: UniProt:P01849
relationship: sequence_of IMR:0100350 ! TCR alpha

[Term]
id: IMR:0002375
name: TVA1_HUMAN
exact_synonym: "T-cell receptor alpha chain V region HPB-MLT" [UniProt:P04436]
xref_analog: UniProt:P04436
relationship: sequence_of IMR:0100350 ! TCR alpha

[Term]
id: IMR:0002376
name: TVA1_MOUSE
exact_synonym: "T-cell receptor alpha chain V region PHDS58" [UniProt:P01738]
xref_analog: UniProt:P01738
relationship: sequence_of IMR:0100350 ! TCR alpha

[Term]
id: IMR:0002377
name: TVA2_HUMAN
exact_synonym: "T-cell receptor alpha chain V region CTL-L17" [UniProt:P04437]
exact_synonym: "TCRA" [UniProt:P04437]
xref_analog: UniProt:P04437
relationship: sequence_of IMR:0100350 ! TCR alpha

[Term]
id: IMR:0002378
name: TVA2_MOUSE
exact_synonym: "T-cell receptor alpha chain V region 2B4" [UniProt:P01739]
xref_analog: UniProt:P01739
relationship: sequence_of IMR:0100350 ! TCR alpha

[Term]
id: IMR:0002379
name: TVA3_HUMAN
exact_synonym: "T-cell receptor alpha chain V region PY14" [UniProt:P01737]
xref_analog: UniProt:P01737
relationship: sequence_of IMR:0100350 ! TCR alpha

[Term]
id: IMR:0002380
name: TVA3_MOUSE
exact_synonym: "T-cell receptor alpha chain V region CTL-F3" [UniProt:P06323]
xref_analog: UniProt:P06323
relationship: sequence_of IMR:0100350 ! TCR alpha

[Term]
id: IMR:0002381
name: TCB1_MOUSE
exact_synonym: "T-cell receptor beta-1 chain C region" [UniProt:P01852]
xref_analog: UniProt:P01852
relationship: sequence_of IMR:0100351 ! TCR beta

[Term]
id: IMR:0002382
name: TCB2_MOUSE
exact_synonym: "T-cell receptor beta-2 chain C region" [UniProt:P01851]
xref_analog: UniProt:P01851
relationship: sequence_of IMR:0100351 ! TCR beta

[Term]
id: IMR:0002383
name: TRBC1_HUMAN
exact_synonym: "BV05S1J2.2" [EntrezGene:28639, HGNC:12156]
exact_synonym: "MGC88817" [EntrezGene:28639]
exact_synonym: "T cell receptor beta constant 1" [EntrezGene:28639, HGNC:12156]
exact_synonym: "T-cell receptor beta-1 chain C region" [UniProt:P01850]
exact_synonym: "TCRBC1" [EntrezGene:28639, HGNC:12156]
exact_synonym: "TRBC1" [UniProt:P01850, EntrezGene:28639, HGNC:12156]
xref_analog: UniProt:P01850
relationship: sequence_of IMR:0100351 ! TCR beta

[Term]
id: IMR:0002384
name: TVB1_HUMAN
exact_synonym: "T cell receptor beta variable 12-3" [HGNC:12185, EntrezGene:28577]
exact_synonym: "T-cell receptor beta chain V region YT35" [UniProt:P01733]
exact_synonym: "TCRBV12S3" [HGNC:12185, EntrezGene:28577]
exact_synonym: "TCRBV8S1" [HGNC:12185, EntrezGene:28577, UniProt:P01733]
exact_synonym: "TRBV12-3" [HGNC:12185, EntrezGene:28577, UniProt:P01733]
exact_synonym: "TRBV123" [HGNC:12185, EntrezGene:28577]
xref_analog: UniProt:P01733
relationship: sequence_of IMR:0100351 ! TCR beta

[Term]
id: IMR:0002385
name: TVB1_MOUSE
exact_synonym: "T-cell receptor beta chain V region 3H.25" [UniProt:P01734]
xref_analog: UniProt:P01734
relationship: sequence_of IMR:0100351 ! TCR beta

[Term]
id: IMR:0002386
name: TVB2_HUMAN
exact_synonym: "T cell receptor beta locus" [EntrezGene:6957, HGNC:12155]
exact_synonym: "T-cell receptor beta chain V region CTL-L17" [UniProt:P04435]
exact_synonym: "TCRB" [UniProt:P04435, EntrezGene:6957]
exact_synonym: "TRB" [EntrezGene:6957, HGNC:12155]
exact_synonym: "TRB@" [EntrezGene:6957, HGNC:12155]
xref_analog: UniProt:P04435
relationship: sequence_of IMR:0100351 ! TCR beta

[Term]
id: IMR:0002387
name: TVB2_MOUSE
exact_synonym: "T-cell receptor beta chain V region 86T1" [UniProt:P01735]
xref_analog: UniProt:P01735
relationship: sequence_of IMR:0100351 ! TCR beta

[Term]
id: IMR:0002388
name: TVB3_MOUSE
exact_synonym: "T-cell receptor beta chain V region PHDS203" [UniProt:P01736]
xref_analog: UniProt:P01736
relationship: sequence_of IMR:0100351 ! TCR beta

[Term]
id: IMR:0002389
name: TVB4_MOUSE
exact_synonym: "T-cell receptor beta chain V region LB2" [UniProt:P04212]
xref_analog: UniProt:P04212
relationship: sequence_of IMR:0100351 ! TCR beta

[Term]
id: IMR:0002390
name: TVB5_MOUSE
exact_synonym: "T-cell receptor beta chain V region C5" [UniProt:P04213]
xref_analog: UniProt:P04213
relationship: sequence_of IMR:0100351 ! TCR beta

[Term]
id: IMR:0002391
name: TVB6_MOUSE
exact_synonym: "T-cell receptor beta chain V region E1" [UniProt:P04214]
xref_analog: UniProt:P04214
relationship: sequence_of IMR:0100351 ! TCR beta

[Term]
id: IMR:0002392
name: TVB7_MOUSE
exact_synonym: "T-cell receptor beta chain V region CTL-F3" [UniProt:P06320]
xref_analog: UniProt:P06320
relationship: sequence_of IMR:0100351 ! TCR beta

[Term]
id: IMR:0002393
name: TVB8_MOUSE
exact_synonym: "T-cell receptor beta chain V region A20.2.25" [UniProt:P06321]
xref_analog: UniProt:P06321
relationship: sequence_of IMR:0100351 ! TCR beta

[Term]
id: IMR:0002394
name: TCR gamma
exact_synonym: "T-cell receptor gamma" []
is_a: IMR:0000151 ! TCR family
relationship: part_of IMR:0002407 ! TCR gamma-delta dimer

[Term]
id: IMR:0002395
name: TCR delta
exact_synonym: "T-cell receptor delta" []
is_a: IMR:0000151 ! TCR family
relationship: part_of IMR:0002407 ! TCR gamma-delta dimer

[Term]
id: IMR:0002396
name: TCC1_MOUSE
exact_synonym: "T-cell receptor gamma chain C region C10.5" [UniProt:P01853]
xref_analog: UniProt:P01853
relationship: sequence_of IMR:0002394 ! TCR gamma

[Term]
id: IMR:0002397
name: TCC2_MOUSE
exact_synonym: "T-cell receptor gamma chain C region C7.5" [UniProt:P03985]
xref_analog: UniProt:P03985
relationship: sequence_of IMR:0002394 ! TCR gamma

[Term]
id: IMR:0002398
name: TCC3_MOUSE
exact_synonym: "T-cell receptor gamma chain C region DFL12" [UniProt:P06334]
xref_analog: UniProt:P06334
relationship: sequence_of IMR:0002394 ! TCR gamma

[Term]
id: IMR:0002399
name: TCC4_MOUSE
exact_synonym: "T-cell receptor gamma chain C region 5/10-13" [UniProt:P06335]
xref_analog: UniProt:P06335
relationship: sequence_of IMR:0002394 ! TCR gamma

[Term]
id: IMR:0002400
name: TRGC2_HUMAN
exact_synonym: "T cell receptor gamma constant 2" [HGNC:12276, EntrezGene:6967]
exact_synonym: "T-cell receptor gamma chain C region PT-gamma-1/2" [UniProt:P03986]
exact_synonym: "T-cell receptor gamma-2 chain C region" [UniProt:P03986]
exact_synonym: "TCRGC2" [UniProt:P03986, EntrezGene:6967]
exact_synonym: "TRGC2" [UniProt:P03986, HGNC:12276, EntrezGene:6967]
exact_synonym: "TRGC2(2X)" [HGNC:12276, EntrezGene:6967]
exact_synonym: "TRGC2(3X)" [HGNC:12276, EntrezGene:6967]
xref_analog: UniProt:P03986
relationship: sequence_of IMR:0002394 ! TCR gamma

[Term]
id: IMR:0002401
name: TVC1_MOUSE
exact_synonym: "T-cell receptor gamma chain V region V108A" [UniProt:P01740]
xref_analog: UniProt:P01740
relationship: sequence_of IMR:0002394 ! TCR gamma

[Term]
id: IMR:0002402
name: TVC2_MOUSE
exact_synonym: "T-cell receptor gamma chain V region V108B" [UniProt:P03978]
xref_analog: UniProt:P03978
relationship: sequence_of IMR:0002394 ! TCR gamma

[Term]
id: IMR:0002403
name: TVC3_MOUSE
exact_synonym: "T-cell receptor gamma chain V region DFL12" [UniProt:P06324]
xref_analog: UniProt:P06324
relationship: sequence_of IMR:0002394 ! TCR gamma

[Term]
id: IMR:0002404
name: TVC4_MOUSE
exact_synonym: "Gm16602" [UniProt:P06325]
exact_synonym: "T-cell receptor gamma chain V region 5/10-13" [UniProt:P06325]
xref_analog: UniProt:P06325
relationship: sequence_of IMR:0002394 ! TCR gamma

[Term]
id: IMR:0002405
name: TVC_HUMAN
exact_synonym: "T cell receptor gamma variable 3" [HGNC:12288, EntrezGene:6976]
exact_synonym: "T-cell receptor gamma chain V region PT-gamma-1/2" [UniProt:P03979]
exact_synonym: "TCRB" [UniProt:P03979]
exact_synonym: "TCRGV3" [EntrezGene:6976]
exact_synonym: "TRGV3" [UniProt:P03979, HGNC:12288, EntrezGene:6976]
exact_synonym: "V1S3" [HGNC:12288, EntrezGene:6976]
xref_analog: UniProt:P03979
relationship: sequence_of IMR:0002394 ! TCR gamma

[Term]
id: IMR:0002406
name: TCR alpha-beta dimer
relationship: part_of IMR:0002408 ! alpha beta TCR-CD3 complex

[Term]
id: IMR:0002407
name: TCR gamma-delta dimer
relationship: part_of IMR:0002409 ! gamma delta TCR-CD3 complex

[Term]
id: IMR:0002408
name: alpha beta TCR-CD3 complex
exact_synonym: "TCR-CD3 complex" []
xref_analog: GO:0042105
is_a: IMR:0002372 ! TCR-CD3 complex

[Term]
id: IMR:0002409
name: gamma delta TCR-CD3 complex
xref_analog: GO:0042106
is_a: IMR:0002372 ! TCR-CD3 complex

[Term]
id: IMR:0002410
name: Ubc13
is_a: IMR:0000328 ! ubiquitin-conjugating enzyme (E2)

[Term]
id: IMR:0002411
name: Uev1A
is_a: IMR:0000328 ! ubiquitin-conjugating enzyme (E2)

[Term]
id: IMR:0002412
name: UBE2N_HUMAN
exact_synonym: "BENDLESS, DROSOPHILA, HOMOLOG OF" [MIM:603679]
exact_synonym: "Bendless-like ubiquitin-conjugating enzyme" [UniProt:P61088]
exact_synonym: "BLU" [UniProt:P61088]
exact_synonym: "EC 6.3.2.19" [UniProt:P61088]
exact_synonym: "MGC131857" [EntrezGene:7334]
exact_synonym: "MGC8489" [EntrezGene:7334, HGNC:12492]
exact_synonym: "Ubc13" [MIM:603679, UniProt:P61088]
exact_synonym: "UBC13" [EntrezGene:7334, HGNC:12492]
exact_synonym: "UbcH-ben" [EntrezGene:7334, HGNC:12492]
exact_synonym: "UBCHBEN" [MIM:603679]
exact_synonym: "UBE2N" [MIM:603679, EntrezGene:7334, HGNC:12492, UniProt:P61088]
exact_synonym: "Ubiquitin carrier protein N" [UniProt:P61088]
exact_synonym: "UBIQUITIN-CONJUGATING ENZYME 13, S. CEREVISIAE, HOMOLOG OF" [MIM:603679]
exact_synonym: "Ubiquitin-conjugating enzyme E2 N" [UniProt:P61088]
exact_synonym: "UBIQUITIN-CONJUGATING ENZYME E2N" [MIM:603679]
exact_synonym: "ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)" [EntrezGene:7334, HGNC:12492]
exact_synonym: "Ubiquitin-protein ligase N" [UniProt:P61088]
xref_analog: UniProt:P61088
relationship: sequence_of IMR:0002410 ! Ubc13

[Term]
id: IMR:0002413
name: UBE2N_RAT
exact_synonym: "Bendless-like ubiquitin-conjugating enzyme" [UniProt:Q9EQX9]
exact_synonym: "EC 6.3.2.19" [UniProt:Q9EQX9]
exact_synonym: "Ube2n" [RGD:621096, UniProt:Q9EQX9]
exact_synonym: "Ubiquitin carrier protein N" [UniProt:Q9EQX9]
exact_synonym: "Ubiquitin-conjugating enzyme E2 N" [UniProt:Q9EQX9]
exact_synonym: "ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)" [RGD:621096]
exact_synonym: "Ubiquitin-protein ligase N" [UniProt:Q9EQX9]
xref_analog: UniProt:Q9EQX9
relationship: sequence_of IMR:0002410 ! Ubc13

[Term]
id: IMR:0002414
name: UB2V1_HUMAN
exact_synonym: "CIR1" [EntrezGene:7335]
exact_synonym: "CROC-1" [EntrezGene:7335, HGNC:12494, UniProt:Q13404]
exact_synonym: "CROC1" [EntrezGene:7335, HGNC:12494, MIM:602995, UniProt:Q13404]
exact_synonym: "TRAF6-regulated IKK activator 1 beta Uev1A" [UniProt:Q13404]
exact_synonym: "UBE2V" [EntrezGene:7335, UniProt:Q13404]
exact_synonym: "UBE2V1" [EntrezGene:7335, HGNC:12494, MIM:602995, UniProt:Q13404]
exact_synonym: "Ubiquitin-conjugating enzyme E2 variant 1" [MIM:602995, UniProt:Q13404]
exact_synonym: "ubiquitin-conjugating enzyme E2 variant 1" [EntrezGene:7335, HGNC:12494]
exact_synonym: "UEV-1" [EntrezGene:7335, HGNC:12494, UniProt:Q13404]
exact_synonym: "UEV1" [EntrezGene:7335, MIM:602995, UniProt:Q13404]
exact_synonym: "UEV1A" [EntrezGene:7335, HGNC:12494, MIM:602995]
xref_analog: UniProt:Q13404
relationship: sequence_of IMR:0002411 ! Uev1A

[Term]
id: IMR:0002415
name: UB2V1_MOUSE
exact_synonym: "CROC-1" [UniProt:Q9CZY3]
exact_synonym: "Croc1" [UniProt:Q9CZY3]
exact_synonym: "CROC1" [MGI:1913839]
exact_synonym: "D7Bwg1382e" [MGI:1913839]
exact_synonym: "Ube2v1" [UniProt:Q9CZY3, MGI:1913839]
exact_synonym: "Ubiquitin-conjugating enzyme E2 variant 1" [UniProt:Q9CZY3]
exact_synonym: "ubiquitin-conjugating enzyme E2 variant 1" [MGI:1913839]
exact_synonym: "UEV-1" [UniProt:Q9CZY3]
xref_analog: UniProt:Q9CZY3
relationship: sequence_of IMR:0002411 ! Uev1A

[Term]
id: IMR:0002416
name: LBP
exact_synonym: "lipopolysaccharide binding protein" []
is_a: IMR:0001791 ! pattern recognition receptor

[Term]
id: IMR:0002417
name: LBP_HUMAN
exact_synonym: "LBP" [HGNC:6517, UniProt:P18428, MIM:151990, EntrezGene:3929]
exact_synonym: "lipopolysaccharide binding protein" [HGNC:6517, EntrezGene:3929]
exact_synonym: "Lipopolysaccharide-binding protein" [UniProt:P18428, MIM:151990]
exact_synonym: "LPS-BINDING PROTEIN" [MIM:151990]
exact_synonym: "MGC22233" [EntrezGene:3929]
xref_analog: UniProt:P18428
relationship: sequence_of IMR:0002416 ! LBP

[Term]
id: IMR:0002418
name: LBP_MOUSE
exact_synonym: "LBP" [UniProt:Q61805]
exact_synonym: "Lbp" [MGI:1098776, UniProt:Q61805]
exact_synonym: "lipopolysaccharide binding protein" [MGI:1098776]
exact_synonym: "Lipopolysaccharide-binding protein" [UniProt:Q61805]
xref_analog: UniProt:Q61805
relationship: sequence_of IMR:0002416 ! LBP

[Term]
id: IMR:0002419
name: LBP_RAT
exact_synonym: "LBP" [UniProt:Q63313]
exact_synonym: "Lbp" [RGD:61865, UniProt:Q63313]
exact_synonym: "lipopolysaccharide binding protein" [RGD:61865]
exact_synonym: "Lipopolysaccharide-binding protein" [UniProt:Q63313]
xref_analog: UniProt:Q63313
relationship: sequence_of IMR:0002416 ! LBP

[Term]
id: IMR:0002420
name: MP2K7_MOUSE
exact_synonym: "c-Jun N-terminal kinase kinase 2" [UniProt:Q8CE90]
exact_synonym: "Dual specificity mitogen-activated protein kinase kinase 7" [UniProt:Q8CE90]
exact_synonym: "EC 2.7.12.2" [UniProt:Q8CE90]
exact_synonym: "JNK kinase 2" [UniProt:Q8CE90]
exact_synonym: "JNK-activating kinase 2" [UniProt:Q8CE90]
exact_synonym: "JNKK 2" [UniProt:Q8CE90]
exact_synonym: "Jnkk2" [MGI:1346871]
exact_synonym: "MAP kinase kinase 7" [UniProt:Q8CE90, MGI:1346871]
exact_synonym: "Map2k7" [UniProt:Q8CE90, MGI:1346871]
exact_synonym: "MAPK/ERK kinase 7" [UniProt:Q8CE90]
exact_synonym: "MAPKK 7" [UniProt:Q8CE90]
exact_synonym: "MEK 7" [UniProt:Q8CE90]
exact_synonym: "mitogen-activated protein kinase kinase 7" [MGI:1346871]
exact_synonym: "Mkk7" [UniProt:Q8CE90]
exact_synonym: "MKK7" [MGI:1346871]
exact_synonym: "Prkmk7" [MGI:1346871]
exact_synonym: "sek2" [MGI:1346871]
xref_analog: UniProt:Q8CE90
relationship: sequence_of IMR:0100455 ! MKK7(JNKK2)

[Term]
id: IMR:0002421
name: JNK_DROME
exact_synonym: "basket" [FlyBase:FBgn0000229]
exact_synonym: "bsk" [FlyBase:FBgn0000229, UniProt:P92208]
exact_synonym: "Bsk" [FlyBase:FBgn0000229]
exact_synonym: "CG5680" [FlyBase:FBgn0000229]
exact_synonym: "D-JNK" [FlyBase:FBgn0000229]
exact_synonym: "D-junk" [FlyBase:FBgn0000229]
exact_synonym: "DBSK/JNK" [FlyBase:FBgn0000229]
exact_synonym: "dJNK" [FlyBase:FBgn0000229, UniProt:P92208]
exact_synonym: "DJNK" [FlyBase:FBgn0000229]
exact_synonym: "DJNK/bsk" [FlyBase:FBgn0000229]
exact_synonym: "EC 2.7.11.24" [UniProt:P92208]
exact_synonym: "JNK" [FlyBase:FBgn0000229, UniProt:P92208]
exact_synonym: "JNK/SAPK" [FlyBase:FBgn0000229]
exact_synonym: "Jun kinase" [FlyBase:FBgn0000229]
exact_synonym: "Jun N-terminal kinase" [FlyBase:FBgn0000229]
exact_synonym: "Jun-kinase" [FlyBase:FBgn0000229]
exact_synonym: "Junk" [FlyBase:FBgn0000229]
exact_synonym: "Protein basket" [UniProt:P92208]
exact_synonym: "SAPKa" [FlyBase:FBgn0000229]
exact_synonym: "Stress-activated protein kinase JNK" [UniProt:P92208]
xref_analog: UniProt:P92208
relationship: sequence_of IMR:0000225 ! JNK/SAPK

[Term]
id: IMR:0002422
name: HEP_DROME
exact_synonym: "CG2190" [FlyBase:FBgn0010303]
exact_synonym: "CG4353" [FlyBase:FBgn0010303]
exact_synonym: "DHEP/MKK7" [FlyBase:FBgn0010303]
exact_synonym: "DMKK7" [FlyBase:FBgn0010303]
exact_synonym: "Dual specificity mitogen-activated protein kinase kinase hemipterous" [UniProt:Q23977]
exact_synonym: "EC 2.7.12.2" [UniProt:Q23977]
exact_synonym: "hem" [UniProt:Q23977, FlyBase:FBgn0010303]
exact_synonym: "hemipterous" [FlyBase:FBgn0010303]
exact_synonym: "hep" [UniProt:Q23977, FlyBase:FBgn0010303]
exact_synonym: "HEP" [FlyBase:FBgn0010303]
exact_synonym: "HEP/MKK7" [FlyBase:FBgn0010303]
exact_synonym: "hp" [FlyBase:FBgn0010303]
exact_synonym: "JNKK" [FlyBase:FBgn0010303]
exact_synonym: "l(1)7P1" [FlyBase:FBgn0010303]
exact_synonym: "l(1)G0107" [FlyBase:FBgn0010303]
exact_synonym: "l(1)G0208" [FlyBase:FBgn0010303]
exact_synonym: "MAPKK" [UniProt:Q23977]
exact_synonym: "MKK7" [UniProt:Q23977, FlyBase:FBgn0010303]
xref_analog: UniProt:Q23977
relationship: sequence_of IMR:0000259 ! MAPKK

[Term]
id: IMR:0002423
name: JRA_DROME
exact_synonym: "AP-1" [FlyBase:FBgn0001291]
exact_synonym: "AP1" [FlyBase:FBgn0001291]
exact_synonym: "c-Jun" [FlyBase:FBgn0001291]
exact_synonym: "CG2275" [FlyBase:FBgn0001291]
exact_synonym: "cJun" [FlyBase:FBgn0001291]
exact_synonym: "Complementation group V" [FlyBase:FBgn0001291]
exact_synonym: "d-JRA" [FlyBase:FBgn0001291]
exact_synonym: "D-jun" [FlyBase:FBgn0001291]
exact_synonym: "d-jun" [FlyBase:FBgn0001291]
exact_synonym: "d-Jun" [FlyBase:FBgn0001291]
exact_synonym: "D-Jun" [FlyBase:FBgn0001291]
exact_synonym: "dAP-1" [FlyBase:FBgn0001291]
exact_synonym: "dJRA" [FlyBase:FBgn0001291, UniProt:P18289]
exact_synonym: "dJra" [FlyBase:FBgn0001291]
exact_synonym: "dJun" [FlyBase:FBgn0001291, UniProt:P18289]
exact_synonym: "Djun" [FlyBase:FBgn0001291]
exact_synonym: "dJUN" [FlyBase:FBgn0001291]
exact_synonym: "DJUN" [FlyBase:FBgn0001291]
exact_synonym: "DJun" [FlyBase:FBgn0001291]
exact_synonym: "dm-Jun" [FlyBase:FBgn0001291]
exact_synonym: "Jra" [FlyBase:FBgn0001291, UniProt:P18289]
exact_synonym: "JRA" [FlyBase:FBgn0001291]
exact_synonym: "jra" [FlyBase:FBgn0001291]
exact_synonym: "jun" [FlyBase:FBgn0001291, UniProt:P18289]
exact_synonym: "Jun" [FlyBase:FBgn0001291]
exact_synonym: "Jun oncogene" [FlyBase:FBgn0001291]
exact_synonym: "Jun-related antigen" [FlyBase:FBgn0001291, UniProt:P18289]
exact_synonym: "l(2)46Ef" [FlyBase:FBgn0001291]
exact_synonym: "l(2)IA109" [FlyBase:FBgn0001291]
exact_synonym: "l(2R)IA109" [FlyBase:FBgn0001291]
exact_synonym: "lethal(2)1A109" [FlyBase:FBgn0001291]
exact_synonym: "lethal(2)IA109" [FlyBase:FBgn0001291]
exact_synonym: "Transcription factor AP-1" [UniProt:P18289]
exact_synonym: "V" [FlyBase:FBgn0001291]
xref_analog: UniProt:P18289
relationship: sequence_of IMR:0000416 ! JUN

[Term]
id: IMR:0002424
name: FOSLA_DROME
exact_synonym: "AP-1" [UniProt:P21525, FlyBase:FBgn0001297]
exact_synonym: "AP1" [FlyBase:FBgn0001297]
exact_synonym: "c-Fos" [FlyBase:FBgn0001297]
exact_synonym: "CG15507" [FlyBase:FBgn0001297]
exact_synonym: "CG15509" [FlyBase:FBgn0001297]
exact_synonym: "CG33956" [FlyBase:FBgn0001297]
exact_synonym: "d-fos" [FlyBase:FBgn0001297]
exact_synonym: "D-fos" [FlyBase:FBgn0001297]
exact_synonym: "D-Fos" [FlyBase:FBgn0001297]
exact_synonym: "dAP-1" [FlyBase:FBgn0001297]
exact_synonym: "Dfos" [UniProt:P21525, FlyBase:FBgn0001297]
exact_synonym: "dFos" [FlyBase:FBgn0001297]
exact_synonym: "DFos" [FlyBase:FBgn0001297]
exact_synonym: "DFOS" [FlyBase:FBgn0001297]
exact_synonym: "dFra" [UniProt:P21525, FlyBase:FBgn0001297]
exact_synonym: "DFra" [FlyBase:FBgn0001297]
exact_synonym: "dFRA" [FlyBase:FBgn0001297]
exact_synonym: "dlhD" [FlyBase:FBgn0001297]
exact_synonym: "dorsal holes D" [FlyBase:FBgn0001297]
exact_synonym: "fos" [FlyBase:FBgn0001297]
exact_synonym: "Fos" [FlyBase:FBgn0001297]
exact_synonym: "Fos-related antigen" [UniProt:P21525, FlyBase:FBgn0001297]
exact_synonym: "Fra" [UniProt:P21525, FlyBase:FBgn0001297]
exact_synonym: "kay" [UniProt:P21525, FlyBase:FBgn0001297]
exact_synonym: "kayak" [FlyBase:FBgn0001297]
exact_synonym: "shroud" [FlyBase:FBgn0001297]
exact_synonym: "sro" [FlyBase:FBgn0001297]
exact_synonym: "Transcription factor kayak, isoforms A/B/F" [UniProt:P21525]
xref_analog: UniProt:P21525
relationship: sequence_of IMR:0000415 ! FOS

[Term]
id: IMR:0002425
name: MHC class I alpha chain
exact_synonym: "alpha chain" []
exact_synonym: "heavy chain" []
relationship: part_of IMR:0000143 ! MHC class I molecule

[Term]
id: IMR:0002426
name: MHC class II alpha chain
exact_synonym: "alpha chain" []
relationship: part_of IMR:0000144 ! MHC class II molecule

[Term]
id: IMR:0002427
name: MHC class II beta chain
exact_synonym: "beta chain" []
relationship: part_of IMR:0000144 ! MHC class II molecule

[Term]
id: IMR:0002428
name: 1A01_HUMAN
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-1 alpha chain" [UniProt:P30443]
exact_synonym: "HLA-A" [UniProt:P30443, EntrezGene:3105, HGNC:4931]
exact_synonym: "HLAA" [UniProt:P30443, EntrezGene:3105]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*1" [UniProt:P30443]
xref_analog: UniProt:P30443
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002429
name: 1A02_HUMAN
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-2 alpha chain" [UniProt:P01892]
exact_synonym: "HLA-A" [UniProt:P01892, EntrezGene:3105, HGNC:4931]
exact_synonym: "HLAA" [UniProt:P01892, EntrezGene:3105]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*2" [UniProt:P01892]
xref_analog: UniProt:P01892
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002430
name: 1A03_HUMAN
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-3 alpha chain" [UniProt:P04439]
exact_synonym: "HLA-A" [UniProt:P04439, EntrezGene:3105, HGNC:4931]
exact_synonym: "HLAA" [UniProt:P04439, EntrezGene:3105]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*3" [UniProt:P04439]
xref_analog: UniProt:P04439
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002431
name: 1A11_HUMAN
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-11 alpha chain" [UniProt:P13746]
exact_synonym: "HLA-A" [EntrezGene:3105, UniProt:P13746, HGNC:4931]
exact_synonym: "HLAA" [EntrezGene:3105, UniProt:P13746]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*11" [UniProt:P13746]
xref_analog: UniProt:P13746
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002432
name: 1A23_HUMAN
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-23 alpha chain" [UniProt:P30447]
exact_synonym: "HLA class I histocompatibility antigen, A-9 alpha chain" [UniProt:P30447]
exact_synonym: "HLA-A" [EntrezGene:3105, HGNC:4931, UniProt:P30447]
exact_synonym: "HLAA" [EntrezGene:3105, UniProt:P30447]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*23" [UniProt:P30447]
xref_analog: UniProt:P30447
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002433
name: 1A24_HUMAN
exact_synonym: "Aw-24" [UniProt:P05534]
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-24 alpha chain" [UniProt:P05534]
exact_synonym: "HLA class I histocompatibility antigen, A-9 alpha chain" [UniProt:P05534]
exact_synonym: "HLA-A" [EntrezGene:3105, UniProt:P05534, HGNC:4931]
exact_synonym: "HLAA" [EntrezGene:3105, UniProt:P05534]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*24" [UniProt:P05534]
xref_analog: UniProt:P05534
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002434
name: 1A25_HUMAN
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-10 alpha chain" [UniProt:P18462]
exact_synonym: "HLA class I histocompatibility antigen, A-25 alpha chain" [UniProt:P18462]
exact_synonym: "HLA-A" [EntrezGene:3105, UniProt:P18462, HGNC:4931]
exact_synonym: "HLAA" [EntrezGene:3105, UniProt:P18462]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*25" [UniProt:P18462]
xref_analog: UniProt:P18462
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002435
name: 1A26_HUMAN
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-26 alpha chain" [UniProt:P30450]
exact_synonym: "HLA-A" [EntrezGene:3105, UniProt:P30450, HGNC:4931]
exact_synonym: "HLAA" [EntrezGene:3105, UniProt:P30450]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*26" [UniProt:P30450]
xref_analog: UniProt:P30450
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002436
name: 1A29_HUMAN
exact_synonym: "Aw-19" [UniProt:P30512]
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-29 alpha chain" [UniProt:P30512]
exact_synonym: "HLA-A" [UniProt:P30512, EntrezGene:3105, HGNC:4931]
exact_synonym: "HLAA" [UniProt:P30512, EntrezGene:3105]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*29" [UniProt:P30512]
xref_analog: UniProt:P30512
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002437
name: 1A30_HUMAN
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-30 alpha chain" [UniProt:P16188]
exact_synonym: "HLA-A" [EntrezGene:3105, UniProt:P16188, HGNC:4931]
exact_synonym: "HLAA" [EntrezGene:3105, UniProt:P16188]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*30" [UniProt:P16188]
xref_analog: UniProt:P16188
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002438
name: 1A31_HUMAN
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-31 alpha chain" [UniProt:P16189]
exact_synonym: "HLA-A" [EntrezGene:3105, UniProt:P16189, HGNC:4931]
exact_synonym: "HLAA" [EntrezGene:3105, UniProt:P16189]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*31" [UniProt:P16189]
xref_analog: UniProt:P16189
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002439
name: 1A32_HUMAN
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-32 alpha chain" [UniProt:P10314]
exact_synonym: "HLA-A" [UniProt:P10314, EntrezGene:3105, HGNC:4931]
exact_synonym: "HLAA" [UniProt:P10314, EntrezGene:3105]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*32" [UniProt:P10314]
xref_analog: UniProt:P10314
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002440
name: 1A33_HUMAN
exact_synonym: "Aw-19" [UniProt:P16190]
exact_synonym: "Aw-33" [UniProt:P16190]
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-33 alpha chain" [UniProt:P16190]
exact_synonym: "HLA-A" [UniProt:P16190, EntrezGene:3105, HGNC:4931]
exact_synonym: "HLAA" [UniProt:P16190, EntrezGene:3105]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*33" [UniProt:P16190]
xref_analog: UniProt:P16190
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002441
name: 1A34_HUMAN
exact_synonym: "Aw-34" [UniProt:P30453]
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-10 alpha chain" [UniProt:P30453]
exact_synonym: "HLA class I histocompatibility antigen, A-34 alpha chain" [UniProt:P30453]
exact_synonym: "HLA-A" [UniProt:P30453, EntrezGene:3105, HGNC:4931]
exact_synonym: "HLAA" [UniProt:P30453, EntrezGene:3105]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*34" [UniProt:P30453]
xref_analog: UniProt:P30453
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002442
name: 1A36_HUMAN
exact_synonym: "Aw-36" [UniProt:P30455]
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-36 alpha chain" [UniProt:P30455]
exact_synonym: "HLA-A" [EntrezGene:3105, UniProt:P30455, HGNC:4931]
exact_synonym: "HLAA" [EntrezGene:3105, UniProt:P30455]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*36" [UniProt:P30455]
xref_analog: UniProt:P30455
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002443
name: 1A43_HUMAN
exact_synonym: "Aw-43" [UniProt:P30456]
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-43 alpha chain" [UniProt:P30456]
exact_synonym: "HLA-A" [UniProt:P30456, EntrezGene:3105, HGNC:4931]
exact_synonym: "HLAA" [UniProt:P30456, EntrezGene:3105]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*43" [UniProt:P30456]
xref_analog: UniProt:P30456
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002444
name: 1A66_HUMAN
exact_synonym: "Aw-66" [UniProt:P30457]
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-10 alpha chain" [UniProt:P30457]
exact_synonym: "HLA class I histocompatibility antigen, A-66 alpha chain" [UniProt:P30457]
exact_synonym: "HLA-A" [EntrezGene:3105, UniProt:P30457, HGNC:4931]
exact_synonym: "HLAA" [EntrezGene:3105, UniProt:P30457]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*66" [UniProt:P30457]
xref_analog: UniProt:P30457
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002445
name: 1A68_HUMAN
exact_synonym: "Aw-68" [UniProt:P01891]
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-28 alpha chain" [UniProt:P01891]
exact_synonym: "HLA class I histocompatibility antigen, A-68 alpha chain" [UniProt:P01891]
exact_synonym: "HLA-A" [UniProt:P01891, EntrezGene:3105, HGNC:4931]
exact_synonym: "HLAA" [UniProt:P01891, EntrezGene:3105]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*68" [UniProt:P01891]
xref_analog: UniProt:P01891
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002446
name: 1A69_HUMAN
exact_synonym: "Aw-69" [UniProt:P10316]
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-28 alpha chain" [UniProt:P10316]
exact_synonym: "HLA class I histocompatibility antigen, A-69 alpha chain" [UniProt:P10316]
exact_synonym: "HLA-A" [EntrezGene:3105, UniProt:P10316, HGNC:4931]
exact_synonym: "HLAA" [EntrezGene:3105, UniProt:P10316]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*69" [UniProt:P10316]
xref_analog: UniProt:P10316
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002447
name: 1A74_HUMAN
exact_synonym: "Aw-19" [UniProt:P30459]
exact_synonym: "Aw-74" [UniProt:P30459]
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-74 alpha chain" [UniProt:P30459]
exact_synonym: "HLA-A" [EntrezGene:3105, UniProt:P30459, HGNC:4931]
exact_synonym: "HLAA" [EntrezGene:3105, UniProt:P30459]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*74" [UniProt:P30459]
xref_analog: UniProt:P30459
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002448
name: 1A80_HUMAN
exact_synonym: "Aw-80" [UniProt:Q09160]
exact_synonym: "FLJ26655" [EntrezGene:3105]
exact_synonym: "HLA class I histocompatibility antigen, A-1 alpha chain" [UniProt:Q09160]
exact_synonym: "HLA class I histocompatibility antigen, A-80 alpha chain" [UniProt:Q09160]
exact_synonym: "HLA-A" [EntrezGene:3105, UniProt:Q09160, HGNC:4931]
exact_synonym: "HLAA" [EntrezGene:3105, UniProt:Q09160]
exact_synonym: "major histocompatibility complex, class I, A" [EntrezGene:3105, HGNC:4931]
exact_synonym: "MHC class I antigen A*80" [UniProt:Q09160]
xref_analog: UniProt:Q09160
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002449
name: 1B07_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-7 alpha chain" [UniProt:P01889]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P01889, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P01889, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*7" [UniProt:P01889]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P01889
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002450
name: 1B08_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-8 alpha chain" [UniProt:P30460]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P30460, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30460, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*8" [UniProt:P30460]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30460
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002451
name: 1B13_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-13 alpha chain" [UniProt:P30461]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P30461, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30461, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*13" [UniProt:P30461]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30461
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002452
name: 1B14_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-14 alpha chain" [UniProt:P30462]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P30462, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30462, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*14" [UniProt:P30462]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30462
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002453
name: 1B15_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-15 alpha chain" [UniProt:P30464]
exact_synonym: "HLA-B" [UniProt:P30464, HGNC:4932, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30464, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*15" [UniProt:P30464]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30464
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002454
name: 1B18_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-18 alpha chain" [UniProt:P30466]
exact_synonym: "HLA-B" [UniProt:P30466, HGNC:4932, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30466, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*18" [UniProt:P30466]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30466
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002455
name: 1B27_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-27 alpha chain" [UniProt:P03989]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P03989, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P03989, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*27" [UniProt:P03989]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P03989
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002456
name: 1B35_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-35 alpha chain" [UniProt:P30685]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P30685, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30685, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*35" [UniProt:P30685]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30685
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002457
name: 1B37_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-37 alpha chain" [UniProt:P18463]
exact_synonym: "HLA-B" [UniProt:P18463, HGNC:4932, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P18463, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*37" [UniProt:P18463]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P18463
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002458
name: 1B38_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "Bw-4" [UniProt:Q95365]
exact_synonym: "HLA class I histocompatibility antigen, B-38 alpha chain" [UniProt:Q95365]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:Q95365, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:Q95365, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*38" [UniProt:Q95365]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:Q95365
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002459
name: 1B39_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-39 alpha chain" [UniProt:P30475]
exact_synonym: "HLA-B" [UniProt:P30475, HGNC:4932, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30475, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*39" [UniProt:P30475]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30475
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002460
name: 1B40_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "Bw-60" [UniProt:Q04826]
exact_synonym: "HLA class I histocompatibility antigen, B-40 alpha chain" [UniProt:Q04826]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:Q04826, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:Q04826, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*40" [UniProt:Q04826]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:Q04826
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002461
name: 1B41_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "Bw-41" [UniProt:P30479]
exact_synonym: "HLA class I histocompatibility antigen, B-41 alpha chain" [UniProt:P30479]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P30479, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30479, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*41" [UniProt:P30479]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30479
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002462
name: 1B42_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-42 alpha chain" [UniProt:P30480]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P30480, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30480, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*42" [UniProt:P30480]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30480
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002463
name: 1B44_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "Bw-44" [UniProt:P30481]
exact_synonym: "HLA class I histocompatibility antigen, B-44 alpha chain" [UniProt:P30481]
exact_synonym: "HLA-B" [UniProt:P30481, HGNC:4932, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30481, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*44" [UniProt:P30481]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30481
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002464
name: 1B45_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "Bw-45" [UniProt:P30483]
exact_synonym: "HLA class I histocompatibility antigen, B-45 alpha chain" [UniProt:P30483]
exact_synonym: "HLA-B" [HGNC:4932, EntrezGene:3106, UniProt:P30483]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [EntrezGene:3106, UniProt:P30483]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*45" [UniProt:P30483]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30483
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002465
name: 1B46_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "Bw-46" [UniProt:P30484]
exact_synonym: "HLA class I histocompatibility antigen, B-46 alpha chain" [UniProt:P30484]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P30484, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30484, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*46" [UniProt:P30484]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30484
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002466
name: 1B47_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "Bw-47" [UniProt:P30485]
exact_synonym: "HLA class I histocompatibility antigen, B-47 alpha chain" [UniProt:P30485]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P30485, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30485, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*47" [UniProt:P30485]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30485
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002467
name: 1B48_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "Bw-48" [UniProt:P30486]
exact_synonym: "HLA class I histocompatibility antigen, B-48 alpha chain" [UniProt:P30486]
exact_synonym: "HLA-B" [HGNC:4932, EntrezGene:3106, UniProt:P30486]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [EntrezGene:3106, UniProt:P30486]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*48" [UniProt:P30486]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30486
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002468
name: 1B49_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-21 alpha chain" [UniProt:P30487]
exact_synonym: "HLA class I histocompatibility antigen, B-49 alpha chain" [UniProt:P30487]
exact_synonym: "HLA-B" [UniProt:P30487, HGNC:4932, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30487, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*49" [UniProt:P30487]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30487
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002469
name: 1B50_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "Bw-50" [UniProt:P30488]
exact_synonym: "HLA class I histocompatibility antigen, B-21 alpha chain" [UniProt:P30488]
exact_synonym: "HLA class I histocompatibility antigen, B-50 alpha chain" [UniProt:P30488]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P30488, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30488, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*50" [UniProt:P30488]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30488
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002470
name: 1B51_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-51 alpha chain" [UniProt:P18464]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P18464, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P18464, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*51" [UniProt:P18464]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P18464
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002471
name: 1B52_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "Bw-52" [UniProt:P30490]
exact_synonym: "HLA class I histocompatibility antigen, B-5 alpha chain" [UniProt:P30490]
exact_synonym: "HLA class I histocompatibility antigen, B-52 alpha chain" [UniProt:P30490]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P30490, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30490, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*52" [UniProt:P30490]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30490
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002472
name: 1B53_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "Bw-53" [UniProt:P30491]
exact_synonym: "HLA class I histocompatibility antigen, B-53 alpha chain" [UniProt:P30491]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P30491, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30491, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*53" [UniProt:P30491]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30491
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002473
name: 1B54_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "Bw-22" [UniProt:P30492]
exact_synonym: "Bw-54" [UniProt:P30492]
exact_synonym: "HLA class I histocompatibility antigen, B-54 alpha chain" [UniProt:P30492]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P30492, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30492, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*54" [UniProt:P30492]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30492
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002474
name: 1B55_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "Bw-55" [UniProt:P30493]
exact_synonym: "HLA class I histocompatibility antigen, B-12 alpha chain" [UniProt:P30493]
exact_synonym: "HLA class I histocompatibility antigen, B-55 alpha chain" [UniProt:P30493]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P30493, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30493, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*55" [UniProt:P30493]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30493
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002475
name: 1B56_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "Bw-22" [UniProt:P30495]
exact_synonym: "Bw-56" [UniProt:P30495]
exact_synonym: "HLA class I histocompatibility antigen, B-56 alpha chain" [UniProt:P30495]
exact_synonym: "HLA-B" [UniProt:P30495, HGNC:4932, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30495, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*56" [UniProt:P30495]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30495
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002476
name: 1B57_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "Bw-57" [UniProt:P18465]
exact_synonym: "HLA class I histocompatibility antigen, B-57 alpha chain" [UniProt:P18465]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P18465, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P18465, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*57" [UniProt:P18465]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P18465
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002477
name: 1B58_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "Bw-58" [UniProt:P10319]
exact_synonym: "HLA class I histocompatibility antigen, B-58 alpha chain" [UniProt:P10319]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P10319, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P10319, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*58" [UniProt:P10319]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P10319
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002478
name: 1B59_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-59 alpha chain" [UniProt:Q29940]
exact_synonym: "HLA-B" [HGNC:4932, EntrezGene:3106, UniProt:Q29940]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [EntrezGene:3106, UniProt:Q29940]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*59" [UniProt:Q29940]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:Q29940
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002479
name: 1B67_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-67 alpha chain" [UniProt:Q29836]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:Q29836, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:Q29836, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*67" [UniProt:Q29836]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:Q29836
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002480
name: 1B73_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-73 alpha chain" [UniProt:Q31612]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:Q31612, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:Q31612, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*73" [UniProt:Q31612]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:Q31612
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002481
name: 1B78_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-78 alpha chain" [UniProt:P30498]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:P30498, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:P30498, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*78" [UniProt:P30498]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:P30498
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002482
name: 1B81_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "B'DT" [UniProt:Q31610]
exact_synonym: "HLA class I histocompatibility antigen, B-81 alpha chain" [UniProt:Q31610]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:Q31610, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:Q31610, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*81" [UniProt:Q31610]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:Q31610
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002483
name: 1B82_HUMAN
exact_synonym: "AS" [EntrezGene:3106]
exact_synonym: "HLA class I histocompatibility antigen, B-82 alpha chain" [UniProt:Q29718]
exact_synonym: "HLA-B" [HGNC:4932, UniProt:Q29718, EntrezGene:3106]
exact_synonym: "HLA-B27" [EntrezGene:3106]
exact_synonym: "HLA-B73" [EntrezGene:3106]
exact_synonym: "HLAB" [UniProt:Q29718, EntrezGene:3106]
exact_synonym: "major histocompatibility complex, class I, B" [HGNC:4932, EntrezGene:3106]
exact_synonym: "MGC111087" [EntrezGene:3106]
exact_synonym: "MHC class I antigen B*82" [UniProt:Q29718]
exact_synonym: "SPDA1" [EntrezGene:3106]
xref_analog: UniProt:Q29718
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002484
name: 1C01_HUMAN
exact_synonym: "D6S204" [EntrezGene:3107]
exact_synonym: "FLJ27082" [EntrezGene:3107]
exact_synonym: "HLA class I histocompatibility antigen, Cw-1 alpha chain" [UniProt:P30499]
exact_synonym: "HLA-C" [EntrezGene:3107, HGNC:4933, UniProt:P30499, MIM:142840]
exact_synonym: "HLA-C HISTOCOMPATIBILITY TYPE" [MIM:142840]
exact_synonym: "HLA-Cw" [EntrezGene:3107]
exact_synonym: "HLA-JY3" [EntrezGene:3107]
exact_synonym: "HLAC" [UniProt:P30499]
exact_synonym: "HLC-C" [EntrezGene:3107]
exact_synonym: "major histocompatibility complex, class I, C" [EntrezGene:3107, HGNC:4933, MIM:142840]
exact_synonym: "MHC class I antigen Cw*1" [UniProt:P30499]
exact_synonym: "PSORS1" [EntrezGene:3107]
xref_analog: UniProt:P30499
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002485
name: 1C02_HUMAN
exact_synonym: "D6S204" [EntrezGene:3107]
exact_synonym: "FLJ27082" [EntrezGene:3107]
exact_synonym: "HLA class I histocompatibility antigen, Cw-2 alpha chain" [UniProt:P30501]
exact_synonym: "HLA-C" [EntrezGene:3107, UniProt:P30501, HGNC:4933, MIM:142840]
exact_synonym: "HLA-C HISTOCOMPATIBILITY TYPE" [MIM:142840]
exact_synonym: "HLA-Cw" [EntrezGene:3107]
exact_synonym: "HLA-JY3" [EntrezGene:3107]
exact_synonym: "HLAC" [UniProt:P30501]
exact_synonym: "HLC-C" [EntrezGene:3107]
exact_synonym: "major histocompatibility complex, class I, C" [EntrezGene:3107, HGNC:4933, MIM:142840]
exact_synonym: "MHC class I antigen Cw*2" [UniProt:P30501]
exact_synonym: "PSORS1" [EntrezGene:3107]
xref_analog: UniProt:P30501
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002486
name: 1C03_HUMAN
exact_synonym: "D6S204" [EntrezGene:3107]
exact_synonym: "FLJ27082" [EntrezGene:3107]
exact_synonym: "HLA class I histocompatibility antigen, Cw-3 alpha chain" [UniProt:P04222]
exact_synonym: "HLA-C" [UniProt:P04222, EntrezGene:3107, HGNC:4933, MIM:142840]
exact_synonym: "HLA-C HISTOCOMPATIBILITY TYPE" [MIM:142840]
exact_synonym: "HLA-Cw" [EntrezGene:3107]
exact_synonym: "HLA-JY3" [EntrezGene:3107]
exact_synonym: "HLAC" [UniProt:P04222]
exact_synonym: "HLC-C" [EntrezGene:3107]
exact_synonym: "major histocompatibility complex, class I, C" [EntrezGene:3107, HGNC:4933, MIM:142840]
exact_synonym: "MHC class I antigen Cw*3" [UniProt:P04222]
exact_synonym: "PSORS1" [EntrezGene:3107]
xref_analog: UniProt:P04222
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002487
name: 1C04_HUMAN
exact_synonym: "D6S204" [EntrezGene:3107]
exact_synonym: "FLJ27082" [EntrezGene:3107]
exact_synonym: "HLA class I histocompatibility antigen, Cw-4 alpha chain" [UniProt:P30504]
exact_synonym: "HLA-C" [EntrezGene:3107, HGNC:4933, UniProt:P30504, MIM:142840]
exact_synonym: "HLA-C HISTOCOMPATIBILITY TYPE" [MIM:142840]
exact_synonym: "HLA-Cw" [EntrezGene:3107]
exact_synonym: "HLA-JY3" [EntrezGene:3107]
exact_synonym: "HLAC" [UniProt:P30504]
exact_synonym: "HLC-C" [EntrezGene:3107]
exact_synonym: "major histocompatibility complex, class I, C" [EntrezGene:3107, HGNC:4933, MIM:142840]
exact_synonym: "MHC class I antigen Cw*4" [UniProt:P30504]
exact_synonym: "PSORS1" [EntrezGene:3107]
xref_analog: UniProt:P30504
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002488
name: 1C05_HUMAN
exact_synonym: "D6S204" [EntrezGene:3107]
exact_synonym: "FLJ27082" [EntrezGene:3107]
exact_synonym: "HLA class I histocompatibility antigen, Cw-5 alpha chain" [UniProt:Q9TNN7]
exact_synonym: "HLA-C" [EntrezGene:3107, UniProt:Q9TNN7, HGNC:4933, MIM:142840]
exact_synonym: "HLA-C HISTOCOMPATIBILITY TYPE" [MIM:142840]
exact_synonym: "HLA-Cw" [EntrezGene:3107]
exact_synonym: "HLA-JY3" [EntrezGene:3107]
exact_synonym: "HLAC" [UniProt:Q9TNN7]
exact_synonym: "HLC-C" [EntrezGene:3107]
exact_synonym: "major histocompatibility complex, class I, C" [EntrezGene:3107, HGNC:4933, MIM:142840]
exact_synonym: "MHC class I antigen Cw*5" [UniProt:Q9TNN7]
exact_synonym: "PSORS1" [EntrezGene:3107]
xref_analog: UniProt:Q9TNN7
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002489
name: 1C06_HUMAN
exact_synonym: "D6S204" [EntrezGene:3107]
exact_synonym: "FLJ27082" [EntrezGene:3107]
exact_synonym: "HLA class I histocompatibility antigen, Cw-6 alpha chain" [UniProt:Q29963]
exact_synonym: "HLA-C" [EntrezGene:3107, HGNC:4933, UniProt:Q29963, MIM:142840]
exact_synonym: "HLA-C HISTOCOMPATIBILITY TYPE" [MIM:142840]
exact_synonym: "HLA-Cw" [EntrezGene:3107]
exact_synonym: "HLA-JY3" [EntrezGene:3107]
exact_synonym: "HLAC" [UniProt:Q29963]
exact_synonym: "HLC-C" [EntrezGene:3107]
exact_synonym: "major histocompatibility complex, class I, C" [EntrezGene:3107, HGNC:4933, MIM:142840]
exact_synonym: "MHC class I antigen Cw*6" [UniProt:Q29963]
exact_synonym: "PSORS1" [EntrezGene:3107]
xref_analog: UniProt:Q29963
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002490
name: 1C07_HUMAN
exact_synonym: "D6S204" [EntrezGene:3107]
exact_synonym: "FLJ27082" [EntrezGene:3107]
exact_synonym: "HLA class I histocompatibility antigen, Cw-7 alpha chain" [UniProt:P10321]
exact_synonym: "HLA-C" [EntrezGene:3107, UniProt:P10321, HGNC:4933, MIM:142840]
exact_synonym: "HLA-C HISTOCOMPATIBILITY TYPE" [MIM:142840]
exact_synonym: "HLA-Cw" [EntrezGene:3107]
exact_synonym: "HLA-JY3" [EntrezGene:3107]
exact_synonym: "HLAC" [UniProt:P10321]
exact_synonym: "HLC-C" [EntrezGene:3107]
exact_synonym: "major histocompatibility complex, class I, C" [EntrezGene:3107, HGNC:4933, MIM:142840]
exact_synonym: "MHC class I antigen Cw*7" [UniProt:P10321]
exact_synonym: "PSORS1" [EntrezGene:3107]
xref_analog: UniProt:P10321
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002491
name: 1C08_HUMAN
exact_synonym: "D6S204" [EntrezGene:3107]
exact_synonym: "FLJ27082" [EntrezGene:3107]
exact_synonym: "HLA class I histocompatibility antigen, Cw-8 alpha chain" [UniProt:P30505]
exact_synonym: "HLA-C" [EntrezGene:3107, HGNC:4933, UniProt:P30505, MIM:142840]
exact_synonym: "HLA-C HISTOCOMPATIBILITY TYPE" [MIM:142840]
exact_synonym: "HLA-Cw" [EntrezGene:3107]
exact_synonym: "HLA-JY3" [EntrezGene:3107]
exact_synonym: "HLAC" [UniProt:P30505]
exact_synonym: "HLC-C" [EntrezGene:3107]
exact_synonym: "major histocompatibility complex, class I, C" [EntrezGene:3107, HGNC:4933, MIM:142840]
exact_synonym: "MHC class I antigen Cw*8" [UniProt:P30505]
exact_synonym: "PSORS1" [EntrezGene:3107]
xref_analog: UniProt:P30505
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002492
name: 1C12_HUMAN
exact_synonym: "D6S204" [EntrezGene:3107]
exact_synonym: "FLJ27082" [EntrezGene:3107]
exact_synonym: "HLA class I histocompatibility antigen, Cw-12 alpha chain" [UniProt:P30508]
exact_synonym: "HLA-C" [EntrezGene:3107, UniProt:P30508, HGNC:4933, MIM:142840]
exact_synonym: "HLA-C HISTOCOMPATIBILITY TYPE" [MIM:142840]
exact_synonym: "HLA-Cw" [EntrezGene:3107]
exact_synonym: "HLA-JY3" [EntrezGene:3107]
exact_synonym: "HLAC" [UniProt:P30508]
exact_synonym: "HLC-C" [EntrezGene:3107]
exact_synonym: "major histocompatibility complex, class I, C" [EntrezGene:3107, HGNC:4933, MIM:142840]
exact_synonym: "MHC class I antigen Cw*12" [UniProt:P30508]
exact_synonym: "PSORS1" [EntrezGene:3107]
xref_analog: UniProt:P30508
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002493
name: 1C14_HUMAN
exact_synonym: "D6S204" [EntrezGene:3107]
exact_synonym: "FLJ27082" [EntrezGene:3107]
exact_synonym: "HLA class I histocompatibility antigen, Cw-14 alpha chain" [UniProt:P30510]
exact_synonym: "HLA-C" [EntrezGene:3107, UniProt:P30510, HGNC:4933, MIM:142840]
exact_synonym: "HLA-C HISTOCOMPATIBILITY TYPE" [MIM:142840]
exact_synonym: "HLA-Cw" [EntrezGene:3107]
exact_synonym: "HLA-JY3" [EntrezGene:3107]
exact_synonym: "HLAC" [UniProt:P30510]
exact_synonym: "HLC-C" [EntrezGene:3107]
exact_synonym: "major histocompatibility complex, class I, C" [EntrezGene:3107, HGNC:4933, MIM:142840]
exact_synonym: "MHC class I antigen Cw*14" [UniProt:P30510]
exact_synonym: "PSORS1" [EntrezGene:3107]
xref_analog: UniProt:P30510
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002494
name: 1C15_HUMAN
exact_synonym: "D6S204" [EntrezGene:3107]
exact_synonym: "FLJ27082" [EntrezGene:3107]
exact_synonym: "HLA class I histocompatibility antigen, Cw-15 alpha chain" [UniProt:Q07000]
exact_synonym: "HLA-C" [EntrezGene:3107, UniProt:Q07000, HGNC:4933, MIM:142840]
exact_synonym: "HLA-C HISTOCOMPATIBILITY TYPE" [MIM:142840]
exact_synonym: "HLA-Cw" [EntrezGene:3107]
exact_synonym: "HLA-JY3" [EntrezGene:3107]
exact_synonym: "HLAC" [UniProt:Q07000]
exact_synonym: "HLC-C" [EntrezGene:3107]
exact_synonym: "major histocompatibility complex, class I, C" [EntrezGene:3107, HGNC:4933, MIM:142840]
exact_synonym: "MHC class I antigen Cw*15" [UniProt:Q07000]
exact_synonym: "PSORS1" [EntrezGene:3107]
xref_analog: UniProt:Q07000
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002495
name: 1C16_HUMAN
exact_synonym: "D6S204" [EntrezGene:3107]
exact_synonym: "FLJ27082" [EntrezGene:3107]
exact_synonym: "HLA class I histocompatibility antigen, Cw-16 alpha chain" [UniProt:Q29960]
exact_synonym: "HLA-C" [EntrezGene:3107, UniProt:Q29960, HGNC:4933, MIM:142840]
exact_synonym: "HLA-C HISTOCOMPATIBILITY TYPE" [MIM:142840]
exact_synonym: "HLA-Cw" [EntrezGene:3107]
exact_synonym: "HLA-JY3" [EntrezGene:3107]
exact_synonym: "HLAC" [UniProt:Q29960]
exact_synonym: "HLC-C" [EntrezGene:3107]
exact_synonym: "major histocompatibility complex, class I, C" [EntrezGene:3107, HGNC:4933, MIM:142840]
exact_synonym: "MHC class I antigen Cw*16" [UniProt:Q29960]
exact_synonym: "PSORS1" [EntrezGene:3107]
xref_analog: UniProt:Q29960
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002496
name: 1C17_HUMAN
exact_synonym: "D6S204" [EntrezGene:3107, UniProt:Q95604]
exact_synonym: "FLJ27082" [EntrezGene:3107]
exact_synonym: "HLA class I histocompatibility antigen, Cw-17 alpha chain" [UniProt:Q95604]
exact_synonym: "HLA-C" [EntrezGene:3107, HGNC:4933, MIM:142840, UniProt:Q95604]
exact_synonym: "HLA-C HISTOCOMPATIBILITY TYPE" [MIM:142840]
exact_synonym: "HLA-Cw" [EntrezGene:3107]
exact_synonym: "HLA-JY3" [EntrezGene:3107, UniProt:Q95604]
exact_synonym: "HLAC" [UniProt:Q95604]
exact_synonym: "HLC-C" [EntrezGene:3107]
exact_synonym: "major histocompatibility complex, class I, C" [EntrezGene:3107, HGNC:4933, MIM:142840]
exact_synonym: "MHC class I antigen Cw*17" [UniProt:Q95604]
exact_synonym: "PSORS1" [EntrezGene:3107]
xref_analog: UniProt:Q95604
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002497
name: 1C18_HUMAN
exact_synonym: "D6S204" [EntrezGene:3107]
exact_synonym: "FLJ27082" [EntrezGene:3107]
exact_synonym: "HLA class I histocompatibility antigen, Cw-18 alpha chain" [UniProt:Q29865]
exact_synonym: "HLA-C" [EntrezGene:3107, HGNC:4933, MIM:142840, UniProt:Q29865]
exact_synonym: "HLA-C HISTOCOMPATIBILITY TYPE" [MIM:142840]
exact_synonym: "HLA-Cw" [EntrezGene:3107]
exact_synonym: "HLA-JY3" [EntrezGene:3107]
exact_synonym: "HLAC" [UniProt:Q29865]
exact_synonym: "HLC-C" [EntrezGene:3107]
exact_synonym: "major histocompatibility complex, class I, C" [EntrezGene:3107, HGNC:4933, MIM:142840]
exact_synonym: "MHC class I antigen Cw*18" [UniProt:Q29865]
exact_synonym: "PSORS1" [EntrezGene:3107]
xref_analog: UniProt:Q29865
relationship: sequence_of IMR:0002425 ! MHC class I alpha chain

[Term]
id: IMR:0002498
name: 2B11_HUMAN
exact_synonym: "DR-1" [UniProt:P04229]
exact_synonym: "DR1" [UniProt:P04229]
exact_synonym: "DRB1" [EntrezGene:3123]
exact_synonym: "DRw10" [EntrezGene:3123]
exact_synonym: "FLJ75017" [EntrezGene:3123]
exact_synonym: "FLJ76359" [EntrezGene:3123]
exact_synonym: "HLA class II histocompatibility antigen, DRB1-1 beta chain" [UniProt:P04229]
exact_synonym: "HLA-DR1B" [EntrezGene:3123]
exact_synonym: "HLA-DRB" [EntrezGene:3123]
exact_synonym: "HLA-DRB1" [HGNC:4948, EntrezGene:3123, UniProt:P04229, MIM:142857]
exact_synonym: "HLA-DRB1*" [EntrezGene:3123]
exact_synonym: "major histocompatibility complex, class II, DR beta 1" [HGNC:4948, EntrezGene:3123]
exact_synonym: "MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR BETA-1" [MIM:142857]
exact_synonym: "MHC class II antigen DRB1*1" [UniProt:P04229]
exact_synonym: "SS1" [EntrezGene:3123]
xref_analog: UniProt:P04229
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002499
name: 2B14_HUMAN
exact_synonym: "DR-4" [UniProt:P13760]
exact_synonym: "DR4" [UniProt:P13760]
exact_synonym: "DRB1" [EntrezGene:3123]
exact_synonym: "DRw10" [EntrezGene:3123]
exact_synonym: "FLJ75017" [EntrezGene:3123]
exact_synonym: "FLJ76359" [EntrezGene:3123]
exact_synonym: "HLA class II histocompatibility antigen, DRB1-4 beta chain" [UniProt:P13760]
exact_synonym: "HLA-DR1B" [EntrezGene:3123]
exact_synonym: "HLA-DRB" [EntrezGene:3123]
exact_synonym: "HLA-DRB1" [HGNC:4948, EntrezGene:3123, MIM:142857, UniProt:P13760]
exact_synonym: "HLA-DRB1*" [EntrezGene:3123]
exact_synonym: "major histocompatibility complex, class II, DR beta 1" [HGNC:4948, EntrezGene:3123]
exact_synonym: "MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR BETA-1" [MIM:142857]
exact_synonym: "MHC class II antigen DRB1*4" [UniProt:P13760]
exact_synonym: "SS1" [EntrezGene:3123]
xref_analog: UniProt:P13760
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002500
name: 2B17_HUMAN
exact_synonym: "DR-7" [UniProt:P13761]
exact_synonym: "DR7" [UniProt:P13761]
exact_synonym: "DRB1" [EntrezGene:3123]
exact_synonym: "DRw10" [EntrezGene:3123]
exact_synonym: "FLJ75017" [EntrezGene:3123]
exact_synonym: "FLJ76359" [EntrezGene:3123]
exact_synonym: "HLA class II histocompatibility antigen, DRB1-7 beta chain" [UniProt:P13761]
exact_synonym: "HLA-DR1B" [EntrezGene:3123]
exact_synonym: "HLA-DRB" [EntrezGene:3123]
exact_synonym: "HLA-DRB1" [HGNC:4948, UniProt:P13761, EntrezGene:3123, MIM:142857]
exact_synonym: "HLA-DRB1*" [EntrezGene:3123]
exact_synonym: "major histocompatibility complex, class II, DR beta 1" [HGNC:4948, EntrezGene:3123]
exact_synonym: "MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR BETA-1" [MIM:142857]
exact_synonym: "MHC class II antigen DRB1*7" [UniProt:P13761]
exact_synonym: "SS1" [EntrezGene:3123]
xref_analog: UniProt:P13761
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002501
name: 2B18_HUMAN
exact_synonym: "DR-8" [UniProt:Q30134]
exact_synonym: "DR8" [UniProt:Q30134]
exact_synonym: "DRB1" [EntrezGene:3123]
exact_synonym: "DRw10" [EntrezGene:3123]
exact_synonym: "DRw8" [UniProt:Q30134]
exact_synonym: "FLJ75017" [EntrezGene:3123]
exact_synonym: "FLJ76359" [EntrezGene:3123]
exact_synonym: "HLA class II histocompatibility antigen, DRB1-8 beta chain" [UniProt:Q30134]
exact_synonym: "HLA-DR1B" [EntrezGene:3123]
exact_synonym: "HLA-DRB" [EntrezGene:3123]
exact_synonym: "HLA-DRB1" [HGNC:4948, EntrezGene:3123, UniProt:Q30134, MIM:142857]
exact_synonym: "HLA-DRB1*" [EntrezGene:3123]
exact_synonym: "major histocompatibility complex, class II, DR beta 1" [HGNC:4948, EntrezGene:3123]
exact_synonym: "MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR BETA-1" [MIM:142857]
exact_synonym: "MHC class II antigen DRB1*8" [UniProt:Q30134]
exact_synonym: "SS1" [EntrezGene:3123]
xref_analog: UniProt:Q30134
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002502
name: 2B19_HUMAN
exact_synonym: "DR-9" [UniProt:Q9TQE0]
exact_synonym: "DR9" [UniProt:Q9TQE0]
exact_synonym: "DRB1" [EntrezGene:3123]
exact_synonym: "DRw10" [EntrezGene:3123]
exact_synonym: "FLJ75017" [EntrezGene:3123]
exact_synonym: "FLJ76359" [EntrezGene:3123]
exact_synonym: "HLA class II histocompatibility antigen, DRB1-9 beta chain" [UniProt:Q9TQE0]
exact_synonym: "HLA-DR1B" [EntrezGene:3123]
exact_synonym: "HLA-DRB" [EntrezGene:3123]
exact_synonym: "HLA-DRB1" [HGNC:4948, UniProt:Q9TQE0, EntrezGene:3123, MIM:142857]
exact_synonym: "HLA-DRB1*" [EntrezGene:3123]
exact_synonym: "major histocompatibility complex, class II, DR beta 1" [HGNC:4948, EntrezGene:3123]
exact_synonym: "MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR BETA-1" [MIM:142857]
exact_synonym: "MHC class II antigen DRB1*9" [UniProt:Q9TQE0]
exact_synonym: "SS1" [EntrezGene:3123]
xref_analog: UniProt:Q9TQE0
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002503
name: 2B1A_HUMAN
alt_id: IMR:0002558
exact_synonym: "DRB1" [EntrezGene:3123]
exact_synonym: "DRw10" [UniProt:Q30167, EntrezGene:3123]
exact_synonym: "FLJ75017" [EntrezGene:3123]
exact_synonym: "FLJ76359" [EntrezGene:3123]
exact_synonym: "HLA class II histocompatibility antigen, DRB1-10 beta chain" [UniProt:Q30167]
exact_synonym: "HLA-DR1B" [EntrezGene:3123]
exact_synonym: "HLA-DRB" [EntrezGene:3123]
exact_synonym: "HLA-DRB1" [HGNC:4948, UniProt:Q30167, EntrezGene:3123, MIM:142857]
exact_synonym: "HLA-DRB1*" [EntrezGene:3123]
exact_synonym: "major histocompatibility complex, class II, DR beta 1" [HGNC:4948, EntrezGene:3123]
exact_synonym: "MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR BETA-1" [MIM:142857]
exact_synonym: "MHC class II antigen DRB1*10" [UniProt:Q30167]
exact_synonym: "SS1" [EntrezGene:3123]
xref_analog: UniProt:Q30167
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002504
name: 2B1B_HUMAN
exact_synonym: "DR-5" [UniProt:P20039]
exact_synonym: "DR5" [UniProt:P20039]
exact_synonym: "DRB1" [EntrezGene:3123]
exact_synonym: "DRw10" [EntrezGene:3123]
exact_synonym: "DRw11" [UniProt:P20039]
exact_synonym: "FLJ75017" [EntrezGene:3123]
exact_synonym: "FLJ76359" [EntrezGene:3123]
exact_synonym: "HLA class II histocompatibility antigen, DRB1-11 beta chain" [UniProt:P20039]
exact_synonym: "HLA-DR1B" [EntrezGene:3123]
exact_synonym: "HLA-DRB" [EntrezGene:3123]
exact_synonym: "HLA-DRB1" [HGNC:4948, EntrezGene:3123, UniProt:P20039, MIM:142857]
exact_synonym: "HLA-DRB1*" [EntrezGene:3123]
exact_synonym: "major histocompatibility complex, class II, DR beta 1" [HGNC:4948, EntrezGene:3123]
exact_synonym: "MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR BETA-1" [MIM:142857]
exact_synonym: "MHC class II antigen DRB1*11" [UniProt:P20039]
exact_synonym: "SS1" [EntrezGene:3123]
xref_analog: UniProt:P20039
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002506
name: DRB3_HUMAN
alt_id: IMR:0002505
exact_synonym: "HLA class II histocompatibility antigen, DR beta 3 chain" [UniProt:P79483]
exact_synonym: "HLA-DR3B" [EntrezGene:3125]
exact_synonym: "HLA-DR52" [MIM:612735]
exact_synonym: "HLA-DRB1" [EntrezGene:3125]
exact_synonym: "HLA-DRB3" [EntrezGene:3125, MIM:612735, HGNC:4951, UniProt:P79483]
exact_synonym: "major histocompatibility complex, class II, DR beta 3" [EntrezGene:3125, HGNC:4951]
exact_synonym: "MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR BETA-3" [MIM:612735]
exact_synonym: "MGC117330" [EntrezGene:3125]
exact_synonym: "MHC class II antigen DRB3" [UniProt:P79483]
xref_analog: UniProt:P79483
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002507
name: DMA_HUMAN
exact_synonym: "D6S222E" [EntrezGene:3108, HGNC:4934]
exact_synonym: "DMA" [EntrezGene:3108, UniProt:P28067]
exact_synonym: "HLA class II histocompatibility antigen, DM alpha chain" [UniProt:P28067]
exact_synonym: "HLA-DM HISTOCOMPATIBILITY TYPE, ALPHA CHAIN" [MIM:142855]
exact_synonym: "HLA-DMA" [EntrezGene:3108, HGNC:4934, MIM:142855, UniProt:P28067]
exact_synonym: "HLADM" [EntrezGene:3108, MIM:142855]
exact_synonym: "major histocompatibility complex, class II, DM alpha" [EntrezGene:3108, HGNC:4934, MIM:142855]
exact_synonym: "MHC class II antigen DMA" [UniProt:P28067]
exact_synonym: "Really interesting new gene 6 protein" [UniProt:P28067]
exact_synonym: "RING6" [EntrezGene:3108, HGNC:4934, MIM:142855, UniProt:P28067]
xref_analog: UniProt:P28067
relationship: sequence_of IMR:0002516 ! nonclassical MHC class II molecule

[Term]
id: IMR:0002508
name: DMB_HUMAN
exact_synonym: "D6S221E" [HGNC:4935, EntrezGene:3109]
exact_synonym: "DMB" [UniProt:P28068]
exact_synonym: "HLA class II histocompatibility antigen, DM beta chain" [UniProt:P28068]
exact_synonym: "HLA-DM HISTOCOMPATIBILITY TYPE, BETA CHAIN" [MIM:142856]
exact_synonym: "HLA-DMB" [MIM:142856, HGNC:4935, EntrezGene:3109, UniProt:P28068]
exact_synonym: "HLADMB" [MIM:142856]
exact_synonym: "major histocompatibility complex, class II, DM beta" [MIM:142856, HGNC:4935, EntrezGene:3109]
exact_synonym: "MHC class II antigen DMB" [UniProt:P28068]
exact_synonym: "Really interesting new gene 7 protein" [UniProt:P28068]
exact_synonym: "RING7" [MIM:142856, HGNC:4935, EntrezGene:3109, UniProt:P28068]
xref_analog: UniProt:P28068
relationship: sequence_of IMR:0002516 ! nonclassical MHC class II molecule

[Term]
id: IMR:0002509
name: DOA_HUMAN
exact_synonym: "HLA class II histocompatibility antigen, DO alpha chain" [UniProt:P06340]
exact_synonym: "HLA-D0-alpha" [HGNC:4936]
exact_synonym: "HLA-DNA" [UniProt:P06340, MIM:142930, EntrezGene:3111]
exact_synonym: "HLA-DOA" [UniProt:P06340, EntrezGene:3111, HGNC:4936]
exact_synonym: "HLA-DZ HISTOCOMPATIBILITY TYPE" [MIM:142930]
exact_synonym: "HLA-DZA" [UniProt:P06340, EntrezGene:3111]
exact_synonym: "HLADZ" [MIM:142930, EntrezGene:3111]
exact_synonym: "MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DN ALPHA" [MIM:142930]
exact_synonym: "major histocompatibility complex, class II, DO alpha" [EntrezGene:3111, HGNC:4936]
exact_synonym: "MHC class II antigen DOA" [UniProt:P06340]
exact_synonym: "MHC DN-alpha" [UniProt:P06340]
exact_synonym: "MHC DZ alpha" [UniProt:P06340]
xref_analog: UniProt:P06340
relationship: sequence_of IMR:0002516 ! nonclassical MHC class II molecule

[Term]
id: IMR:0002510
name: DOB_HUMAN
exact_synonym: "DOB" [EntrezGene:3112]
exact_synonym: "FLJ57033" [EntrezGene:3112]
exact_synonym: "HLA class II histocompatibility antigen, DO beta chain" [UniProt:P13765]
exact_synonym: "HLA-DO" [MIM:142920]
exact_synonym: "HLA-DO HISTOCOMPATIBILITY TYPE" [MIM:142920]
exact_synonym: "HLA-DO HISTOCOMPATIBILITY TYPE, BETA CHAIN" [MIM:600629]
exact_synonym: "HLA-DOB" [UniProt:P13765, HGNC:4937, MIM:600629, EntrezGene:3112]
exact_synonym: "major histocompatibility complex, class II, DO beta" [HGNC:4937, MIM:600629, EntrezGene:3112]
exact_synonym: "MHC class II antigen DOB" [UniProt:P13765]
xref_analog: UniProt:P13765
relationship: sequence_of IMR:0002516 ! nonclassical MHC class II molecule

[Term]
id: IMR:0002511
name: DRA_HUMAN
exact_synonym: "FLJ51114" [EntrezGene:3122]
exact_synonym: "HLA class II histocompatibility antigen, DR alpha chain" [UniProt:P01903]
exact_synonym: "HLA-D HISTOCOMPATIBILITY TYPE" [MIM:142860]
exact_synonym: "HLA-DR HISTOCOMPATIBILITY TYPE" [MIM:142860]
exact_synonym: "HLA-DRA" [EntrezGene:3122, MIM:142860, UniProt:P01903, HGNC:4947]
exact_synonym: "HLA-DRA1" [EntrezGene:3122, MIM:142860, UniProt:P01903]
exact_synonym: "major histocompatibility complex, class II, DR alpha" [EntrezGene:3122, MIM:142860, HGNC:4947]
exact_synonym: "MHC class II antigen DRA" [UniProt:P01903]
exact_synonym: "MLRW" [EntrezGene:3122]
xref_analog: UniProt:P01903
relationship: sequence_of IMR:0002426 ! MHC class II alpha chain

[Term]
id: IMR:0002512
name: DPA1_HUMAN
exact_synonym: "DP(W3)" [UniProt:P20036]
exact_synonym: "DP(W4)" [UniProt:P20036]
exact_synonym: "HLA class II histocompatibility antigen, DP alpha 1 chain" [UniProt:P20036]
exact_synonym: "HLA-DP" [MIM:142880]
exact_synonym: "HLA-DP1A" [EntrezGene:3113, UniProt:P20036]
exact_synonym: "HLA-DPA1" [MIM:142880, HGNC:4938, EntrezGene:3113, UniProt:P20036]
exact_synonym: "HLA-SB" [MIM:142880]
exact_synonym: "HLA-SB alpha chain" [UniProt:P20036]
exact_synonym: "HLA-SB HISTOCOMPATIBILITY TYPE" [MIM:142880]
exact_synonym: "HLADP" [EntrezGene:3113]
exact_synonym: "HLASB" [EntrezGene:3113, UniProt:P20036]
exact_synonym: "major histocompatibility complex, class II, DP alpha 1" [HGNC:4938, EntrezGene:3113]
exact_synonym: "MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DP ALPHA-1" [MIM:142880]
exact_synonym: "MHC class II DP3-alpha" [UniProt:P20036]
exact_synonym: "MHC class II DPA1" [UniProt:P20036]
exact_synonym: "PLT1" [EntrezGene:3113]
xref_analog: UniProt:P20036
relationship: sequence_of IMR:0002426 ! MHC class II alpha chain

[Term]
id: IMR:0002513
name: HFE_HUMAN
exact_synonym: "dJ221C16.10.1" [EntrezGene:3077]
exact_synonym: "hemochromatosis" [EntrezGene:3077, HGNC:4886]
exact_synonym: "Hereditary hemochromatosis protein" [UniProt:Q30201]
exact_synonym: "HFE" [EntrezGene:3077, UniProt:Q30201, HGNC:4886, MIM:613609]
exact_synonym: "HFE GENE" [MIM:613609]
exact_synonym: "HFE1" [EntrezGene:3077]
exact_synonym: "HH" [EntrezGene:3077]
exact_synonym: "HLA-H" [EntrezGene:3077, UniProt:Q30201, HGNC:4886]
exact_synonym: "HLAH" [UniProt:Q30201]
exact_synonym: "MGC103790" [EntrezGene:3077]
exact_synonym: "MVCD7" [EntrezGene:3077]
xref_analog: UniProt:Q30201
relationship: sequence_of IMR:0002515 ! nonclassical MHC class I molecule

[Term]
id: IMR:0002514
name: HLAE_HUMAN
exact_synonym: "DKFZp686P19218" [EntrezGene:3133]
exact_synonym: "EA1.2" [EntrezGene:3133]
exact_synonym: "EA2.1" [EntrezGene:3133]
exact_synonym: "HLA class I histocompatibility antigen, alpha chain E" [UniProt:P13747]
exact_synonym: "HLA-6.2" [EntrezGene:3133, MIM:143010, UniProt:P13747]
exact_synonym: "HLA-E" [EntrezGene:3133, MIM:143010, HGNC:4962, UniProt:P13747]
exact_synonym: "HLA-E HISTOCOMPATIBILITY TYPE" [MIM:143010]
exact_synonym: "HLAE" [MIM:143010, UniProt:P13747]
exact_synonym: "major histocompatibility complex, class I, E" [EntrezGene:3133, MIM:143010, HGNC:4962]
exact_synonym: "MHC" [EntrezGene:3133]
exact_synonym: "MHC class I antigen E" [UniProt:P13747]
exact_synonym: "QA1" [EntrezGene:3133, MIM:143010]
exact_synonym: "QA1, MOUSE, HOMOLOG OF" [MIM:143010]
xref_analog: UniProt:P13747
relationship: sequence_of IMR:0002515 ! nonclassical MHC class I molecule

[Term]
id: IMR:0002515
name: nonclassical MHC class I molecule
def: "The MHC class Ib family members include HLA-E, HLA-F, HLA-G and HFE (HLA-H) in humans and gene products from the H2-M, H2-Q and H2-T regions in mice." [PubMed:10607669, PubMed:16860610]
exact_synonym: "MHC class Ib molecule" []
is_a: IMR:0000142 ! MHC

[Term]
id: IMR:0002516
name: nonclassical MHC class II molecule
def: "MHC class II-like proteins are produced from the class II region of the MHC, HLA-DM (DM) and HLA-DO (DO) (called H2-M, or H2-DM and H2-O in the mouse)." [PubMed:10837054]
is_a: IMR:0000142 ! MHC

[Term]
id: IMR:0002517
name: HLAF_HUMAN
exact_synonym: "CDA12" [UniProt:P30511, EntrezGene:3134]
exact_synonym: "cda12 CLASS I GENE" [MIM:143110]
exact_synonym: "HLA class I histocompatibility antigen, alpha chain F" [UniProt:P30511]
exact_synonym: "HLA F antigen" [UniProt:P30511]
exact_synonym: "HLA-5.4" [UniProt:P30511, MIM:143110, EntrezGene:3134]
exact_synonym: "HLA-CDA12" [MIM:143110, EntrezGene:3134]
exact_synonym: "HLA-F" [HGNC:4963, UniProt:P30511, MIM:143110, EntrezGene:3134]
exact_synonym: "HLA-F HISTOCOMPATIBILITY TYPE" [MIM:143110]
exact_synonym: "HLAF" [UniProt:P30511, EntrezGene:3134]
exact_synonym: "Leukocyte antigen F" [UniProt:P30511]
exact_synonym: "major histocompatibility complex, class I, F" [HGNC:4963, MIM:143110, EntrezGene:3134]
exact_synonym: "MHC class I antigen F" [UniProt:P30511]
xref_analog: UniProt:P30511
relationship: sequence_of IMR:0002515 ! nonclassical MHC class I molecule

[Term]
id: IMR:0002518
name: HLAG_HUMAN
exact_synonym: "HLA class I histocompatibility antigen, alpha chain G" [UniProt:P17693]
exact_synonym: "HLA G antigen" [UniProt:P17693]
exact_synonym: "HLA-6.0" [MIM:142871, UniProt:P17693]
exact_synonym: "HLA-G" [EntrezGene:3135, MIM:142871, UniProt:P17693, HGNC:4964]
exact_synonym: "HLA-G HISTOCOMPATIBILITY ANTIGEN, CLASS I" [MIM:142871]
exact_synonym: "HLA60" [MIM:142871]
exact_synonym: "HLAG" [UniProt:P17693]
exact_synonym: "major histocompatibility complex, class I, G" [EntrezGene:3135, HGNC:4964]
exact_synonym: "MHC class I antigen G" [UniProt:P17693]
exact_synonym: "MHC-G" [EntrezGene:3135]
exact_synonym: "T-CELL A LOCUS" [MIM:142871]
exact_synonym: "TCA" [MIM:142871]
xref_analog: UniProt:P17693
relationship: sequence_of IMR:0002515 ! nonclassical MHC class I molecule

[Term]
id: IMR:0002520
name: DQA1_HUMAN
alt_id: IMR:0002519
alt_id: IMR:0002521
alt_id: IMR:0002522
alt_id: IMR:0002523
alt_id: IMR:0002525
exact_synonym: "CD" [EntrezGene:3117]
exact_synonym: "CELIAC1" [HGNC:4942, EntrezGene:3117]
exact_synonym: "DC-1 alpha chain" [UniProt:P01909]
exact_synonym: "DC-alpha" [UniProt:P01909]
exact_synonym: "DQ-A1" [EntrezGene:3117]
exact_synonym: "FLJ27088" [EntrezGene:3117]
exact_synonym: "FLJ27328" [EntrezGene:3117]
exact_synonym: "GSE" [EntrezGene:3117]
exact_synonym: "HLA class II histocompatibility antigen, DQ alpha 1 chain" [UniProt:P01909]
exact_synonym: "HLA-DCA" [UniProt:P01909]
exact_synonym: "HLA-DQ" [MIM:146880]
exact_synonym: "HLA-DQA" [MIM:146880, EntrezGene:3117]
exact_synonym: "HLA-DQA1" [HGNC:4942, MIM:146880, EntrezGene:3117, UniProt:P01909]
exact_synonym: "HLADC HISTOCOMPATIBILITY TYPE" [MIM:146880]
exact_synonym: "major histocompatibility complex, class II, DQ alpha 1" [HGNC:4942, EntrezGene:3117]
exact_synonym: "MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DQ ALPHA-1" [MIM:146880]
exact_synonym: "MGC149527" [EntrezGene:3117]
exact_synonym: "MHC class II DQA1" [UniProt:P01909]
xref_analog: UniProt:P01909
relationship: sequence_of IMR:0002426 ! MHC class II alpha chain

[Term]
id: IMR:0002524
name: DQA2_HUMAN
exact_synonym: "DX alpha chain" [UniProt:P01906]
exact_synonym: "DX-ALPHA" [MIM:613503, EntrezGene:3118]
exact_synonym: "HLA class II histocompatibility antigen, DQ alpha 2 chain" [UniProt:P01906]
exact_synonym: "HLA class II histocompatibility antigen, DQ(6) alpha chain" [UniProt:P01906]
exact_synonym: "HLA-DQA1" [UniProt:P01906]
exact_synonym: "HLA-DQA2" [UniProt:P01906, MIM:613503, HGNC:4943, EntrezGene:3118]
exact_synonym: "HLA-DXA" [UniProt:P01906, MIM:613503, EntrezGene:3118]
exact_synonym: "major histocompatibility complex, class II, DQ alpha 2" [HGNC:4943, EntrezGene:3118]
exact_synonym: "MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DQ ALPHA-2" [MIM:613503]
exact_synonym: "MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DX ALPHA" [MIM:613503]
exact_synonym: "MHC class II DQA2" [UniProt:P01906]
xref_analog: UniProt:P01906
relationship: sequence_of IMR:0002426 ! MHC class II alpha chain

[Term]
id: IMR:0002526
name: DQB1_HUMAN
alt_id: IMR:0002527
alt_id: IMR:0002528
alt_id: IMR:0002529
alt_id: IMR:0002530
exact_synonym: "CELIAC1" [EntrezGene:3119, HGNC:4944]
exact_synonym: "HLA class II histocompatibility antigen, DQ beta 1 chain" [UniProt:P01920]
exact_synonym: "HLA-DQB" [EntrezGene:3119, UniProt:P01920]
exact_synonym: "HLA-DQB1" [EntrezGene:3119, HGNC:4944, MIM:604305, UniProt:P01920]
exact_synonym: "IDDM1" [EntrezGene:3119, HGNC:4944]
exact_synonym: "major histocompatibility complex, class II, DQ beta 1" [EntrezGene:3119, HGNC:4944]
exact_synonym: "MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DQ BETA-1" [MIM:604305]
exact_synonym: "MHC class II antigen DQB1" [UniProt:P01920]
xref_analog: UniProt:P01920
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002531
name: DMA_MOUSE
exact_synonym: "Class II histocompatibility antigen, M alpha chain" [UniProt:P28078]
exact_synonym: "H-2Ma" [MGI:95921]
exact_synonym: "H2-DMa" [UniProt:P28078, MGI:95921]
exact_synonym: "H2-M alpha" [MGI:95921]
exact_synonym: "H2-Ma" [UniProt:P28078, MGI:95921]
exact_synonym: "histocompatibility 2, class II, locus DMa" [MGI:95921]
exact_synonym: "Ma" [UniProt:P28078]
xref_analog: UniProt:P28078
relationship: sequence_of IMR:0002516 ! nonclassical MHC class II molecule

[Term]
id: IMR:0002532
name: DMB_MOUSE
exact_synonym: "Class II histocompatibility antigen, M beta 1 chain" [UniProt:P35737]
exact_synonym: "H-2Mb1" [UniProt:P35737, MGI:95922]
exact_synonym: "H2-DMb1" [UniProt:P35737, MGI:95922]
exact_synonym: "H2-M beta 1 chain" [UniProt:P35737]
exact_synonym: "H2-M beta1" [MGI:95922]
exact_synonym: "H2-Mb1" [MGI:95922]
exact_synonym: "histocompatibility 2, class II, locus Mb1" [MGI:95922]
exact_synonym: "Mb" [UniProt:P35737]
xref_analog: UniProt:P35737
relationship: sequence_of IMR:0002516 ! nonclassical MHC class II molecule

[Term]
id: IMR:0002533
name: HA21_MOUSE
exact_synonym: "H-2 class II histocompatibility antigen, E-D alpha chain" [UniProt:P01904]
exact_synonym: "H-2Ea" [MGI:95900]
exact_synonym: "H2-Ea" [UniProt:P01904]
exact_synonym: "H2-Ea-ps" [MGI:95900]
exact_synonym: "H2-IE-alpha" [UniProt:P01904]
exact_synonym: "histocompatibility 2, class II antigen E alpha, pseudogene" [MGI:95900]
exact_synonym: "I-Ealpha" [MGI:95900]
exact_synonym: "Ia-3" [MGI:95900]
exact_synonym: "Ia3" [MGI:95900]
xref_analog: UniProt:P01904
relationship: sequence_of IMR:0002426 ! MHC class II alpha chain

[Term]
id: IMR:0002534
name: HA22_MOUSE
exact_synonym: "H-2 class II histocompatibility antigen, E-K alpha chain" [UniProt:P04224]
xref_analog: UniProt:P04224
relationship: sequence_of IMR:0002426 ! MHC class II alpha chain

[Term]
id: IMR:0002535
name: HA23_MOUSE
exact_synonym: "H-2 class II histocompatibility antigen, E-U alpha chain" [UniProt:P14439]
xref_analog: UniProt:P14439
relationship: sequence_of IMR:0002426 ! MHC class II alpha chain

[Term]
id: IMR:0002536
name: HA2B_MOUSE
exact_synonym: "A alpha" [MGI:95895]
exact_synonym: "Aalpha" [MGI:95895]
exact_synonym: "H-2 class II histocompatibility antigen, A-B alpha chain" [UniProt:P14434]
exact_synonym: "H-2Aa" [MGI:95895]
exact_synonym: "H2-Aa" [UniProt:P14434, MGI:95895]
exact_synonym: "histocompatibility 2, class II antigen A, alpha" [MGI:95895]
exact_synonym: "I-Aalpha" [MGI:95895]
exact_synonym: "Ia-1" [MGI:95895]
exact_synonym: "Ia1" [MGI:95895]
exact_synonym: "IAalpha" [UniProt:P14434]
xref_analog: UniProt:P14434
relationship: sequence_of IMR:0002426 ! MHC class II alpha chain

[Term]
id: IMR:0002537
name: HA2D_MOUSE
exact_synonym: "A alpha" [MGI:95895]
exact_synonym: "Aalpha" [MGI:95895]
exact_synonym: "H-2 class II histocompatibility antigen, A-D alpha chain" [UniProt:P04228]
exact_synonym: "H-2Aa" [MGI:95895]
exact_synonym: "H2-Aa" [UniProt:P04228, MGI:95895]
exact_synonym: "histocompatibility 2, class II antigen A, alpha" [MGI:95895]
exact_synonym: "I-Aalpha" [MGI:95895]
exact_synonym: "Ia-1" [MGI:95895]
exact_synonym: "Ia1" [MGI:95895]
xref_analog: UniProt:P04228
relationship: sequence_of IMR:0002426 ! MHC class II alpha chain

[Term]
id: IMR:0002538
name: HA2F_MOUSE
exact_synonym: "A alpha" [MGI:95895]
exact_synonym: "Aalpha" [MGI:95895]
exact_synonym: "H-2 class II histocompatibility antigen, A-F alpha chain" [UniProt:P14435]
exact_synonym: "H-2Aa" [MGI:95895]
exact_synonym: "H2-Aa" [UniProt:P14435, MGI:95895]
exact_synonym: "histocompatibility 2, class II antigen A, alpha" [MGI:95895]
exact_synonym: "I-Aalpha" [MGI:95895]
exact_synonym: "Ia-1" [MGI:95895]
exact_synonym: "Ia1" [MGI:95895]
xref_analog: UniProt:P14435
relationship: sequence_of IMR:0002426 ! MHC class II alpha chain

[Term]
id: IMR:0002539
name: HA2J_MOUSE
exact_synonym: "A alpha" [MGI:95895]
exact_synonym: "Aalpha" [MGI:95895]
exact_synonym: "H-2 class II histocompatibility antigen, I-E alpha chain" [UniProt:P23150]
exact_synonym: "H-2Aa" [MGI:95895]
exact_synonym: "H2-Aa" [MGI:95895]
exact_synonym: "histocompatibility 2, class II antigen A, alpha" [MGI:95895]
exact_synonym: "I-Aalpha" [MGI:95895]
exact_synonym: "Ia-1" [MGI:95895]
exact_synonym: "Ia1" [MGI:95895]
xref_analog: UniProt:P23150
relationship: sequence_of IMR:0002426 ! MHC class II alpha chain

[Term]
id: IMR:0002540
name: HA2K_MOUSE
exact_synonym: "A alpha" [MGI:95895]
exact_synonym: "Aalpha" [MGI:95895]
exact_synonym: "H-2 class II histocompatibility antigen, A-K alpha chain" [UniProt:P01910]
exact_synonym: "H-2Aa" [MGI:95895]
exact_synonym: "H2-Aa" [MGI:95895, UniProt:P01910]
exact_synonym: "histocompatibility 2, class II antigen A, alpha" [MGI:95895]
exact_synonym: "I-Aalpha" [MGI:95895]
exact_synonym: "Ia-1" [MGI:95895]
exact_synonym: "Ia1" [MGI:95895]
xref_analog: UniProt:P01910
relationship: sequence_of IMR:0002426 ! MHC class II alpha chain

[Term]
id: IMR:0002541
name: HA2R_MOUSE
exact_synonym: "H-2 class II histocompatibility antigen, A-R alpha chain" [UniProt:P14436]
xref_analog: UniProt:P14436
relationship: sequence_of IMR:0002426 ! MHC class II alpha chain

[Term]
id: IMR:0002542
name: HA2S_MOUSE
exact_synonym: "H-2 class II histocompatibility antigen, A-S alpha chain" [UniProt:P14437]
xref_analog: UniProt:P14437
relationship: sequence_of IMR:0002426 ! MHC class II alpha chain

[Term]
id: IMR:0002543
name: HA2U_MOUSE
exact_synonym: "A alpha" [MGI:95895]
exact_synonym: "Aalpha" [MGI:95895]
exact_synonym: "H-2 class II histocompatibility antigen, A-U alpha chain" [UniProt:P14438]
exact_synonym: "H-2Aa" [MGI:95895]
exact_synonym: "H2-Aa" [MGI:95895, UniProt:P14438]
exact_synonym: "histocompatibility 2, class II antigen A, alpha" [MGI:95895]
exact_synonym: "I-Aalpha" [MGI:95895]
exact_synonym: "Ia-1" [MGI:95895]
exact_synonym: "Ia1" [MGI:95895]
xref_analog: UniProt:P14438
relationship: sequence_of IMR:0002426 ! MHC class II alpha chain

[Term]
id: IMR:0002544
name: HB21_MOUSE
exact_synonym: "H-2 class II histocompatibility antigen, E-B beta chain" [UniProt:P04230]
exact_synonym: "H-2Eb" [MGI:95901]
exact_synonym: "H2-Eb1" [MGI:95901, UniProt:P04230]
exact_synonym: "histocompatibility 2, class II antigen E beta" [MGI:95901]
exact_synonym: "Ia-4" [MGI:95901]
exact_synonym: "Ia4" [MGI:95901]
xref_analog: UniProt:P04230
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002545
name: HB22_MOUSE
exact_synonym: "H-2 class II histocompatibility antigen, E-D beta chain" [UniProt:P01915]
xref_analog: UniProt:P01915
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002546
name: HB23_MOUSE
exact_synonym: "H-2 class II histocompatibility antigen, E-S beta chain" [UniProt:P04231]
exact_synonym: "H-2Eb" [MGI:95901]
exact_synonym: "H2-Eb1" [UniProt:P04231, MGI:95901]
exact_synonym: "histocompatibility 2, class II antigen E beta" [MGI:95901]
exact_synonym: "Ia-4" [MGI:95901]
exact_synonym: "Ia4" [MGI:95901]
xref_analog: UniProt:P04231
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002547
name: HB24_MOUSE
exact_synonym: "E-W17" [UniProt:P20040]
exact_synonym: "H-2 class II histocompatibility antigen, E-Q beta chain" [UniProt:P20040]
xref_analog: UniProt:P20040
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002548
name: HB2A_MOUSE
exact_synonym: "A beta" [MGI:103070]
exact_synonym: "Abeta" [MGI:103070]
exact_synonym: "H-2 class II histocompatibility antigen, A beta chain" [UniProt:P14483]
exact_synonym: "H-2Ab" [MGI:103070]
exact_synonym: "H2-Ab" [MGI:103070]
exact_synonym: "H2-Ab1" [UniProt:P14483, MGI:103070]
exact_synonym: "H2-iabeta" [UniProt:P14483]
exact_synonym: "histocompatibility 2, class II antigen A, beta 1" [MGI:103070]
exact_synonym: "I-A<b>" [MGI:103070]
exact_synonym: "I-Abeta" [MGI:103070]
exact_synonym: "Ia-2" [MGI:103070]
exact_synonym: "Ia2" [MGI:103070]
exact_synonym: "IAb" [MGI:103070]
exact_synonym: "Rmcs1" [MGI:103070]
xref_analog: UniProt:P14483
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002549
name: HB2D_MOUSE
exact_synonym: "A beta" [MGI:103070]
exact_synonym: "Abeta" [MGI:103070]
exact_synonym: "H-2 class II histocompatibility antigen, A-D beta chain" [UniProt:P01921]
exact_synonym: "H-2Ab" [MGI:103070]
exact_synonym: "H2-Ab" [MGI:103070]
exact_synonym: "H2-Ab1" [UniProt:P01921, MGI:103070]
exact_synonym: "histocompatibility 2, class II antigen A, beta 1" [MGI:103070]
exact_synonym: "I-A<b>" [MGI:103070]
exact_synonym: "I-Abeta" [MGI:103070]
exact_synonym: "Ia-2" [MGI:103070]
exact_synonym: "Ia2" [MGI:103070]
exact_synonym: "IAb" [MGI:103070]
exact_synonym: "Rmcs1" [MGI:103070]
xref_analog: UniProt:P01921
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002550
name: HB2F_MOUSE
exact_synonym: "A beta" [MGI:103070]
exact_synonym: "Abeta" [MGI:103070]
exact_synonym: "H-2 class II histocompatibility antigen, A-F beta chain" [UniProt:P06346]
exact_synonym: "H-2Ab" [MGI:103070]
exact_synonym: "H2-Ab" [MGI:103070]
exact_synonym: "H2-Ab1" [MGI:103070, UniProt:P06346]
exact_synonym: "histocompatibility 2, class II antigen A, beta 1" [MGI:103070]
exact_synonym: "I-A<b>" [MGI:103070]
exact_synonym: "I-Abeta" [MGI:103070]
exact_synonym: "Ia-2" [MGI:103070]
exact_synonym: "Ia2" [MGI:103070]
exact_synonym: "IAb" [MGI:103070]
exact_synonym: "Rmcs1" [MGI:103070]
xref_analog: UniProt:P06346
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002551
name: HB2I_MOUSE
exact_synonym: "H-2 class II histocompatibility antigen, I-A beta chain" [UniProt:P18468]
exact_synonym: "H-2Eb" [MGI:95901]
exact_synonym: "H2-Eb1" [MGI:95901, UniProt:P18468]
exact_synonym: "histocompatibility 2, class II antigen E beta" [MGI:95901]
exact_synonym: "Ia-4" [MGI:95901]
exact_synonym: "Ia4" [MGI:95901]
xref_analog: UniProt:P18468
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002552
name: HB2J_MOUSE
exact_synonym: "H-2 class II histocompatibility antigen, I-E beta chain" [UniProt:P18469]
exact_synonym: "H-2Eb" [MGI:95901]
exact_synonym: "H2-Eb1" [UniProt:P18469, MGI:95901]
exact_synonym: "histocompatibility 2, class II antigen E beta" [MGI:95901]
exact_synonym: "Ia-4" [MGI:95901]
exact_synonym: "Ia4" [MGI:95901]
xref_analog: UniProt:P18469
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002553
name: HB2K_MOUSE
exact_synonym: "A beta" [MGI:103070]
exact_synonym: "Abeta" [MGI:103070]
exact_synonym: "H-2 class II histocompatibility antigen, A-K beta chain" [UniProt:P06343]
exact_synonym: "H-2Ab" [MGI:103070]
exact_synonym: "H2-Ab" [MGI:103070]
exact_synonym: "H2-Ab1" [UniProt:P06343, MGI:103070]
exact_synonym: "histocompatibility 2, class II antigen A, beta 1" [MGI:103070]
exact_synonym: "I-A<b>" [MGI:103070]
exact_synonym: "I-Abeta" [MGI:103070]
exact_synonym: "Ia-2" [MGI:103070]
exact_synonym: "Ia2" [MGI:103070]
exact_synonym: "IAb" [MGI:103070]
exact_synonym: "Rmcs1" [MGI:103070]
xref_analog: UniProt:P06343
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002554
name: HB2Q_MOUSE
exact_synonym: "A beta" [MGI:103070]
exact_synonym: "Abeta" [MGI:103070]
exact_synonym: "H-2 class II histocompatibility antigen, A-Q beta chain" [UniProt:P06342]
exact_synonym: "H-2Ab" [MGI:103070]
exact_synonym: "H2-Ab" [MGI:103070]
exact_synonym: "H2-Ab1" [UniProt:P06342, MGI:103070]
exact_synonym: "histocompatibility 2, class II antigen A, beta 1" [MGI:103070]
exact_synonym: "I-A<b>" [MGI:103070]
exact_synonym: "I-Abeta" [MGI:103070]
exact_synonym: "Ia-2" [MGI:103070]
exact_synonym: "Ia2" [MGI:103070]
exact_synonym: "IAb" [MGI:103070]
exact_synonym: "Rmcs1" [MGI:103070]
xref_analog: UniProt:P06342
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002555
name: HB2S_MOUSE
exact_synonym: "A beta" [MGI:103070]
exact_synonym: "Abeta" [MGI:103070]
exact_synonym: "H-2 class II histocompatibility antigen, A-S beta chain" [UniProt:P06345]
exact_synonym: "H-2Ab" [MGI:103070]
exact_synonym: "H2-Ab" [MGI:103070]
exact_synonym: "H2-Ab1" [UniProt:P06345, MGI:103070]
exact_synonym: "histocompatibility 2, class II antigen A, beta 1" [MGI:103070]
exact_synonym: "I-A<b>" [MGI:103070]
exact_synonym: "I-Abeta" [MGI:103070]
exact_synonym: "Ia-2" [MGI:103070]
exact_synonym: "Ia2" [MGI:103070]
exact_synonym: "IAb" [MGI:103070]
exact_synonym: "Rmcs1" [MGI:103070]
xref_analog: UniProt:P06345
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002556
name: HB2U_MOUSE
exact_synonym: "H-2 class II histocompatibility antigen, A-U beta chain" [UniProt:P06344]
xref_analog: UniProt:P06344
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002557
name: 2B13_HUMAN
exact_synonym: "Clone P2-beta-3" [UniProt:P01912]
exact_synonym: "DRB1" [EntrezGene:3123]
exact_synonym: "DRw10" [EntrezGene:3123]
exact_synonym: "FLJ75017" [EntrezGene:3123]
exact_synonym: "FLJ76359" [EntrezGene:3123]
exact_synonym: "HLA class II histocompatibility antigen, DRB1-3 chain" [UniProt:P01912]
exact_synonym: "HLA-DR1B" [EntrezGene:3123]
exact_synonym: "HLA-DRB" [EntrezGene:3123]
exact_synonym: "HLA-DRB1" [HGNC:4948, UniProt:P01912, EntrezGene:3123, MIM:142857]
exact_synonym: "HLA-DRB1*" [EntrezGene:3123]
exact_synonym: "major histocompatibility complex, class II, DR beta 1" [HGNC:4948, EntrezGene:3123]
exact_synonym: "MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR BETA-1" [MIM:142857]
exact_synonym: "MHC class II antigen DRB1*3" [UniProt:P01912]
exact_synonym: "SS1" [EntrezGene:3123]
xref_analog: UniProt:P01912
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002559
name: 2B1F_HUMAN
exact_synonym: "DRB1" [EntrezGene:3123]
exact_synonym: "DRw10" [EntrezGene:3123]
exact_synonym: "DW2.2/DR2.2" [UniProt:P01911]
exact_synonym: "FLJ75017" [EntrezGene:3123]
exact_synonym: "FLJ76359" [EntrezGene:3123]
exact_synonym: "HLA class II histocompatibility antigen, DRB1-15 beta chain" [UniProt:P01911]
exact_synonym: "HLA-DR1B" [EntrezGene:3123]
exact_synonym: "HLA-DRB" [EntrezGene:3123]
exact_synonym: "HLA-DRB1" [HGNC:4948, UniProt:P01911, EntrezGene:3123, MIM:142857]
exact_synonym: "HLA-DRB1*" [EntrezGene:3123]
exact_synonym: "HLA-DRB2" [UniProt:P01911]
exact_synonym: "major histocompatibility complex, class II, DR beta 1" [HGNC:4948, EntrezGene:3123]
exact_synonym: "MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR BETA-1" [MIM:142857]
exact_synonym: "MHC class II antigen DRB1*15" [UniProt:P01911]
exact_synonym: "SS1" [EntrezGene:3123]
xref_analog: UniProt:P01911
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002560
name: DRB4_HUMAN
exact_synonym: "DR-13" [EntrezGene:3126]
exact_synonym: "DR-14" [EntrezGene:3126]
exact_synonym: "DR13" [EntrezGene:3126]
exact_synonym: "DR14" [EntrezGene:3126]
exact_synonym: "DRB4" [EntrezGene:3126]
exact_synonym: "HLA class II histocompatibility antigen, DR beta 4 chain" [UniProt:P13762]
exact_synonym: "HLA-DR4B" [EntrezGene:3126]
exact_synonym: "HLA-DRB4" [UniProt:P13762, HGNC:4952, EntrezGene:3126]
exact_synonym: "major histocompatibility complex, class II, DR beta 4" [HGNC:4952, EntrezGene:3126]
exact_synonym: "MHC class II antigen DRB4" [UniProt:P13762]
xref_analog: UniProt:P13762
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002561
name: DPB1_HUMAN
alt_id: IMR:0002562
alt_id: IMR:0002563
alt_id: IMR:0002564
exact_synonym: "DPB1" [EntrezGene:3115]
exact_synonym: "HLA class II histocompatibility antigen, DP beta 1 chain" [UniProt:P04440]
exact_synonym: "HLA class II histocompatibility antigen, DP(W4) beta chain" [UniProt:P04440]
exact_synonym: "HLA-DP HISTOCOMPATIBILITY TYPE, BETA-1 SUBUNIT" [MIM:142858]
exact_synonym: "HLA-DP1B" [UniProt:P04440, EntrezGene:3115]
exact_synonym: "HLA-DPB" [EntrezGene:3115]
exact_synonym: "HLA-DPB1" [UniProt:P04440, EntrezGene:3115, MIM:142858, HGNC:4940]
exact_synonym: "major histocompatibility complex, class II, DP beta 1" [EntrezGene:3115, HGNC:4940]
exact_synonym: "MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DP BETA-1" [MIM:142858]
exact_synonym: "MHC class II antigen DPB1" [UniProt:P04440]
xref_analog: UniProt:P04440
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002565
name: DQB2_HUMAN
exact_synonym: "HLA class II histocompatibility antigen, DQ beta 2 chain" [UniProt:P05538]
exact_synonym: "HLA class II histocompatibility antigen, DX beta chain" [UniProt:P05538]
exact_synonym: "HLA-DQB1" [EntrezGene:3120]
exact_synonym: "HLA-DQB2" [UniProt:P05538, EntrezGene:3120, HGNC:4945]
exact_synonym: "HLA-DXB" [UniProt:P05538, EntrezGene:3120]
exact_synonym: "major histocompatibility complex, class II, DQ beta 2" [EntrezGene:3120, HGNC:4945]
exact_synonym: "MHC class II antigen DQB2" [UniProt:P05538]
xref_analog: UniProt:P05538
relationship: sequence_of IMR:0002427 ! MHC class II beta chain

[Term]
id: IMR:0002566
name: GALK2_MOUSE
exact_synonym: "EC 2.7.1.157" [UniProt:Q68FH4]
exact_synonym: "Galactokinase 2" [UniProt:Q68FH4]
exact_synonym: "galactokinase 2" [MGI:1917226]
exact_synonym: "Galk2" [UniProt:Q68FH4, MGI:1917226]
exact_synonym: "GalNAc kinase" [UniProt:Q68FH4]
exact_synonym: "Gk2" [MGI:1917226]
exact_synonym: "N-acetylgalactosamine kinase" [UniProt:Q68FH4]
xref_analog: UniProt:Q68FH4
relationship: sequence_of IMR:0010261 ! galactokinase

[Term]
id: IMR:0002567
name: hexokinase
def: "The first step in metabolism of glucose is usually phosphorylation, catalyzed by hexokinase. Four distinct isozymes of hexokinase (Type I, Type II, Type III and Type IV (glucokinase)) were separated by ion exchange chromatography or electrophoresis of extracts from various mammalian tissues." [PubMed:12756287]
exact_synonym: "HK" []
xref_analog: GO:0004396
is_a: IMR:0000512 ! kinase

[Term]
id: IMR:0002568
name: adenylate kinase
xref_analog: GO:0004017
is_a: IMR:0000512 ! kinase

[Term]
id: IMR:0002569
name: KAD1_MOUSE
alt_id: IMR:0703200
exact_synonym: "adenylate kinase 1" [MGI:87977]
exact_synonym: "Adenylate kinase isoenzyme 1" [UniProt:Q9R0Y5]
exact_synonym: "AK 1" [UniProt:Q9R0Y5]
exact_synonym: "Ak-1" [MGI:87977]
exact_synonym: "Ak1" [UniProt:Q9R0Y5, MGI:87977]
exact_synonym: "ATP-AMP transphosphorylase 1" [UniProt:Q9R0Y5]
exact_synonym: "EC 2.7.4.3" [UniProt:Q9R0Y5]
exact_synonym: "Myokinase" [UniProt:Q9R0Y5]
xref_analog: UniProt:Q9R0Y5
relationship: sequence_of IMR:0010317 ! adenylate kinase 1

[Term]
id: IMR:0002570
name: adenylate kinase 3
exact_synonym: "AK3" []
is_a: IMR:0002568 ! adenylate kinase

[Term]
id: IMR:0002571
name: KAD3_MOUSE
exact_synonym: "Adenylate kinase 3" [UniProt:Q9WTP7]
exact_synonym: "adenylate kinase 3" [MGI:1860835]
exact_synonym: "Adenylate kinase 3 alpha-like 1" [UniProt:Q9WTP7]
exact_synonym: "AK 3" [UniProt:Q9WTP7]
exact_synonym: "AK-3" [MGI:1860835]
exact_synonym: "Ak3" [MGI:1860835, UniProt:Q9WTP7]
exact_synonym: "Ak3l" [UniProt:Q9WTP7]
exact_synonym: "Ak3l1" [UniProt:Q9WTP7]
exact_synonym: "Akl3l" [UniProt:Q9WTP7]
exact_synonym: "EC 2.7.4.10" [UniProt:Q9WTP7]
exact_synonym: "GTP:AMP phosphotransferase, mitochondrial" [UniProt:Q9WTP7]
xref_analog: UniProt:Q9WTP7
relationship: sequence_of IMR:0002570 ! adenylate kinase 3

[Term]
id: IMR:0002572
name: KAD3_RAT
exact_synonym: "Adenylate kinase 3" [UniProt:P29411]
exact_synonym: "adenylate kinase 3" [RGD:619885]
exact_synonym: "Adenylate kinase 3 alpha-like 1" [UniProt:P29411]
exact_synonym: "AK 3" [UniProt:P29411]
exact_synonym: "Ak3" [UniProt:P29411, RGD:619885]
exact_synonym: "Ak3l1" [UniProt:P29411]
exact_synonym: "Akl3l" [UniProt:P29411]
exact_synonym: "EC 2.7.4.10" [UniProt:P29411]
exact_synonym: "GTP:AMP phosphotransferase, mitochondrial" [UniProt:P29411]
xref_analog: UniProt:P29411
relationship: sequence_of IMR:0002570 ! adenylate kinase 3

[Term]
id: IMR:0002573
name: adenylate kinase 4
exact_synonym: "AK4" []
is_a: IMR:0002568 ! adenylate kinase

[Term]
id: IMR:0002574
name: KAD4_MOUSE
exact_synonym: "Adenylate kinase 3-like" [UniProt:Q9WUR9]
exact_synonym: "adenylate kinase 4" [MGI:87979]
exact_synonym: "Adenylate kinase isoenzyme 4, mitochondrial" [UniProt:Q9WUR9]
exact_synonym: "Ak-3" [MGI:87979]
exact_synonym: "Ak-4" [MGI:87979, UniProt:Q9WUR9]
exact_synonym: "Ak3b" [UniProt:Q9WUR9]
exact_synonym: "Ak3l1" [MGI:87979, UniProt:Q9WUR9]
exact_synonym: "Ak4" [MGI:87979, UniProt:Q9WUR9]
exact_synonym: "ATP-AMP transphosphorylase" [UniProt:Q9WUR9]
exact_synonym: "D4Ertd274e" [MGI:87979]
exact_synonym: "EC 2.7.4.3" [UniProt:Q9WUR9]
xref_analog: UniProt:Q9WUR9
relationship: sequence_of IMR:0002573 ! adenylate kinase 4

[Term]
id: IMR:0002575
name: KAD4_RAT
exact_synonym: "Adenylate kinase 3-like" [UniProt:Q9WUS0]
exact_synonym: "adenylate kinase 3-like 1" [RGD:2078]
exact_synonym: "Adenylate kinase isoenzyme 4, mitochondrial" [UniProt:Q9WUS0]
exact_synonym: "Ak3l1" [RGD:2078, UniProt:Q9WUS0]
exact_synonym: "Ak4" [UniProt:Q9WUS0]
exact_synonym: "ATP-AMP transphosphorylase" [UniProt:Q9WUS0]
exact_synonym: "EC 2.7.4.3" [UniProt:Q9WUS0]
xref_analog: UniProt:Q9WUS0
relationship: sequence_of IMR:0002573 ! adenylate kinase 4

[Term]
id: IMR:0002576
name: inositol 1,4,5-trisphosphate 3-kinase
def: "Ins(1,4,5)P3 3-kinases (IP3-3K) are the enzymes responsible for the ATP-dependent conversion of Ins(1,4,5)P3 to Ins(1,3,4,5)P4. Three mammalian isoforms of this enzyme have so far been isolated and designated the A, B and C isoforms." [PubMed:15093605, PubMed:15740635]
exact_synonym: "Ins(1,4,5)P3 3-kinase" []
exact_synonym: "IP(3) 3-kinase" []
exact_synonym: "IP(3)K" []
exact_synonym: "IP3 3-kinase" []
exact_synonym: "IP3-3K" []
exact_synonym: "IP3K" []
xref_analog: GO:0008440
is_a: IMR:0000264 ! inositol/phosphatidylinositol kinase

[Term]
id: IMR:0002577
name: inositol 1,4,5-trisphosphate 3-kinase A
exact_synonym: "IP3K-A" []
is_a: IMR:0002576 ! inositol 1,4,5-trisphosphate 3-kinase

[Term]
id: IMR:0002578
name: inositol 1,4,5-trisphosphate 3-kinase B
exact_synonym: "IP3K-B" []
is_a: IMR:0002576 ! inositol 1,4,5-trisphosphate 3-kinase

[Term]
id: IMR:0002579
name: inositol 1,4,5-trisphosphate 3-kinase C
exact_synonym: "IP3K-C" []
is_a: IMR:0002576 ! inositol 1,4,5-trisphosphate 3-kinase

[Term]
id: IMR:0002580
name: IP3KA_MOUSE
exact_synonym: "EC 2.7.1.127" [UniProt:Q8R071]
exact_synonym: "Inositol 1,4,5-trisphosphate 3-kinase A" [UniProt:Q8R071]
exact_synonym: "inositol 1,4,5-trisphosphate 3-kinase A" [MGI:1333822]
exact_synonym: "Inositol-trisphosphate 3-kinase A" [UniProt:Q8R071]
exact_synonym: "InsP 3-kinase A" [UniProt:Q8R071]
exact_synonym: "IP3 3-kinase A" [UniProt:Q8R071]
exact_synonym: "IP3-kinase A" [MGI:1333822]
exact_synonym: "IP3K A" [UniProt:Q8R071]
exact_synonym: "Itpka" [UniProt:Q8R071, MGI:1333822]
xref_analog: UniProt:Q8R071
relationship: sequence_of IMR:0002577 ! inositol 1,4,5-trisphosphate 3-kinase A

[Term]
id: IMR:0002581
name: IP3KA_RAT
exact_synonym: "EC 2.7.1.127" [UniProt:P17105]
exact_synonym: "Inositol 1,4,5-trisphosphate 3-kinase A" [UniProt:P17105]
exact_synonym: "inositol 1,4,5-trisphosphate 3-kinase A" [RGD:619950]
exact_synonym: "Inositol-trisphosphate 3-kinase A" [UniProt:P17105]
exact_synonym: "InsP 3-kinase A" [UniProt:P17105]
exact_synonym: "IP3 3-kinase A" [UniProt:P17105]
exact_synonym: "IP3K A" [UniProt:P17105]
exact_synonym: "Itpka" [RGD:619950, UniProt:P17105]
xref_analog: UniProt:P17105
relationship: sequence_of IMR:0002577 ! inositol 1,4,5-trisphosphate 3-kinase A

[Term]
id: IMR:0002582
name: IP3KB_RAT
exact_synonym: "EC 2.7.1.127" [UniProt:P42335]
exact_synonym: "Inositol 1,4,5-trisphosphate 3-kinase B" [UniProt:P42335]
exact_synonym: "inositol 1,4,5-trisphosphate 3-kinase B" [RGD:2932]
exact_synonym: "Inositol-trisphosphate 3-kinase B" [UniProt:P42335]
exact_synonym: "InsP 3-kinase B" [UniProt:P42335]
exact_synonym: "IP3 3-kinase B" [UniProt:P42335]
exact_synonym: "IP3K B" [UniProt:P42335]
exact_synonym: "Itpkb" [UniProt:P42335, RGD:2932]
xref_analog: UniProt:P42335
relationship: sequence_of IMR:0002578 ! inositol 1,4,5-trisphosphate 3-kinase B

[Term]
id: IMR:0002583
name: IP3KC_HUMAN
exact_synonym: "EC 2.7.1.127" [UniProt:Q96DU7]
exact_synonym: "Inositol 1,4,5-trisphosphate 3-kinase C" [UniProt:Q96DU7, MIM:606476]
exact_synonym: "inositol 1,4,5-trisphosphate 3-kinase C" [EntrezGene:80271, HGNC:14897]
exact_synonym: "Inositol-trisphosphate 3-kinase C" [UniProt:Q96DU7]
exact_synonym: "InsP 3-kinase C" [UniProt:Q96DU7]
exact_synonym: "IP3 3-kinase C" [UniProt:Q96DU7]
exact_synonym: "IP3-3KC" [EntrezGene:80271, HGNC:14897]
exact_synonym: "IP3K C" [UniProt:Q96DU7]
exact_synonym: "IP3KC" [EntrezGene:80271, HGNC:14897, UniProt:Q96DU7]
exact_synonym: "ITPKC" [EntrezGene:80271, HGNC:14897, UniProt:Q96DU7, MIM:606476]
xref_analog: UniProt:Q96DU7
relationship: sequence_of IMR:0002579 ! inositol 1,4,5-trisphosphate 3-kinase C

[Term]
id: IMR:0002584
name: IP3KC_MOUSE
exact_synonym: "EC 2.7.1.127" [UniProt:Q7TS72]
exact_synonym: "Inositol 1,4,5-trisphosphate 3-kinase C" [UniProt:Q7TS72]
exact_synonym: "inositol 1,4,5-trisphosphate 3-kinase C" [MGI:2442554]
exact_synonym: "Inositol-trisphosphate 3-kinase C" [UniProt:Q7TS72]
exact_synonym: "InsP 3-kinase C" [UniProt:Q7TS72]
exact_synonym: "IP3 3-kinase C" [UniProt:Q7TS72]
exact_synonym: "IP3K C" [UniProt:Q7TS72]
exact_synonym: "Itpkc" [MGI:2442554, UniProt:Q7TS72]
xref_analog: UniProt:Q7TS72
relationship: sequence_of IMR:0002579 ! inositol 1,4,5-trisphosphate 3-kinase C

[Term]
id: IMR:0002585
name: IP3KC_RAT
exact_synonym: "EC 2.7.1.127" [UniProt:Q80ZG2]
exact_synonym: "Inositol 1,4,5-trisphosphate 3-kinase C" [UniProt:Q80ZG2]
exact_synonym: "inositol 1,4,5-trisphosphate 3-kinase C" [RGD:631336]
exact_synonym: "Inositol-trisphosphate 3-kinase C" [UniProt:Q80ZG2]
exact_synonym: "InsP 3-kinase C" [UniProt:Q80ZG2]
exact_synonym: "IP3 3-kinase C" [UniProt:Q80ZG2]
exact_synonym: "IP3K C" [UniProt:Q80ZG2]
exact_synonym: "Ip3kc" [UniProt:Q80ZG2]
exact_synonym: "Itpkc" [RGD:631336, UniProt:Q80ZG2]
xref_analog: UniProt:Q80ZG2
relationship: sequence_of IMR:0002579 ! inositol 1,4,5-trisphosphate 3-kinase C

[Term]
id: IMR:0002586
name: methionine adenosyltransferase
def: "Methionine adenosyltransferase (MAT) is an ubiquitous enzyme that catalyzes the synthesis of S-adenosylmethionine from methionine and ATP. In mammals, there are two genes coding for MAT. In the liver, MAT is the product of MAT1A gene, which encodes a catalytic subunit (alpha1) that organizes into dimers (MAT III) and tetramers (MAT I). Other cell types express a different MAT gene, namely MAT2A, which codes for the catalytic subunit alpha2 that associates with beta subunit to form MAT II. The beta subunit is a noncatalytic regulatory protein, which is the product of MAT2B gene." [PubMed:11772932, PubMed:12163144, PubMed:9175157]
exact_synonym: "MAT" []
exact_synonym: "S-adenosylmethionine synthetase" []
xref_analog: GO:0004478
is_a: IMR:0010050 ! transferase

[Term]
id: IMR:0002587
name: MAT I
exact_synonym: "methionine adenosyltransferase I" []
is_a: IMR:0002586 ! methionine adenosyltransferase

[Term]
id: IMR:0002588
name: MAT II
exact_synonym: "methionine adenosyltransferase II" []
is_a: IMR:0002586 ! methionine adenosyltransferase

[Term]
id: IMR:0002589
name: MAT III
exact_synonym: "methionine adenosyltransferase III" []
is_a: IMR:0002586 ! methionine adenosyltransferase

[Term]
id: IMR:0002590
name: MAT I/III alpha subunit
exact_synonym: "MAT alpha1" []
exact_synonym: "methionine adenosyltransferase I/III alpha subunit" []
is_a: IMR:0002586 ! methionine adenosyltransferase
relationship: part_of IMR:0002587 ! MAT I
relationship: part_of IMR:0002589 ! MAT III

[Term]
id: IMR:0002591
name: MAT II alpha subunit
exact_synonym: "MAT alpha2" []
exact_synonym: "methionine adenosyltransferase II alpha subunit" []
is_a: IMR:0002586 ! methionine adenosyltransferase
relationship: part_of IMR:0002588 ! MAT II

[Term]
id: IMR:0002592
name: MAT II beta subunit
exact_synonym: "MAT II regulatory subunit" []
exact_synonym: "methionine adenosyltransferase II beta subunit" []
is_a: IMR:0000429 ! enzyme regulator
relationship: part_of IMR:0002588 ! MAT II

[Term]
id: IMR:0002593
name: METK1_MOUSE
exact_synonym: "AdoMet" [MGI:88017]
exact_synonym: "AdoMet synthase 1" [UniProt:Q91X83]
exact_synonym: "Ams" [MGI:88017]
exact_synonym: "EC 2.5.1.6" [UniProt:Q91X83]
exact_synonym: "MAT" [MGI:88017]
exact_synonym: "MAT 1" [UniProt:Q91X83]
exact_synonym: "Mat1a" [MGI:88017, UniProt:Q91X83]
exact_synonym: "MATA1" [MGI:88017]
exact_synonym: "Methionine adenosyltransferase 1" [UniProt:Q91X83]
exact_synonym: "methionine adenosyltransferase I, alpha" [MGI:88017]
exact_synonym: "S-adenosylmethionine synthase isoform type-1" [UniProt:Q91X83]
exact_synonym: "SAMS" [MGI:88017]
exact_synonym: "SAMS1" [MGI:88017]
xref_analog: UniProt:Q91X83
relationship: sequence_of IMR:0002590 ! MAT I/III alpha subunit

[Term]
id: IMR:0002594
name: METK1_RAT
exact_synonym: "AdoMet synthase 1" [UniProt:P13444]
exact_synonym: "Ams1" [UniProt:P13444]
exact_synonym: "EC 2.5.1.6" [UniProt:P13444]
exact_synonym: "MAT 1" [UniProt:P13444]
exact_synonym: "MAT-I/III" [UniProt:P13444]
exact_synonym: "Mat1a" [RGD:3050, UniProt:P13444]
exact_synonym: "Methionine adenosyltransferase 1" [UniProt:P13444]
exact_synonym: "methionine adenosyltransferase I, alpha" [RGD:3050]
exact_synonym: "Methionine adenosyltransferase I/III" [UniProt:P13444]
exact_synonym: "S-adenosylmethionine synthase isoform type-1" [UniProt:P13444]
xref_analog: UniProt:P13444
relationship: sequence_of IMR:0002590 ! MAT I/III alpha subunit

[Term]
id: IMR:0002595
name: METK2_MOUSE
exact_synonym: "AdoMet synthase 2" [UniProt:Q3THS6]
exact_synonym: "EC 2.5.1.6" [UniProt:Q3THS6]
exact_synonym: "MAT 2" [UniProt:Q3THS6]
exact_synonym: "Mat2a" [UniProt:Q3THS6, MGI:2443731]
exact_synonym: "Methionine adenosyltransferase 2" [UniProt:Q3THS6]
exact_synonym: "methionine adenosyltransferase II, alpha" [MGI:2443731]
exact_synonym: "S-adenosylmethionine synthase isoform type-2" [UniProt:Q3THS6]
xref_analog: UniProt:Q3THS6
relationship: sequence_of IMR:0002591 ! MAT II alpha subunit

[Term]
id: IMR:0002596
name: METK2_RAT
exact_synonym: "AdoMet synthase 2" [UniProt:P18298]
exact_synonym: "Ams2" [UniProt:P18298]
exact_synonym: "EC 2.5.1.6" [UniProt:P18298]
exact_synonym: "MAT 2" [UniProt:P18298]
exact_synonym: "MAT-II" [UniProt:P18298]
exact_synonym: "Mat2a" [RGD:619985, UniProt:P18298]
exact_synonym: "Methionine adenosyltransferase 2" [UniProt:P18298]
exact_synonym: "Methionine adenosyltransferase II" [UniProt:P18298]
exact_synonym: "methionine adenosyltransferase II, alpha" [RGD:619985]
exact_synonym: "S-adenosylmethionine synthase isoform type-2" [UniProt:P18298]
xref_analog: UniProt:P18298
relationship: sequence_of IMR:0002591 ! MAT II alpha subunit

[Term]
id: IMR:0002597
name: MAT2B_MOUSE
exact_synonym: "MAT II beta" [UniProt:Q99LB6]
exact_synonym: "Mat2b" [MGI:1913667, UniProt:Q99LB6]
exact_synonym: "MATIIbeta" [MGI:1913667]
exact_synonym: "Methionine adenosyltransferase 2 subunit beta" [UniProt:Q99LB6]
exact_synonym: "Methionine adenosyltransferase II beta" [UniProt:Q99LB6]
exact_synonym: "methionine adenosyltransferase II, beta" [MGI:1913667]
xref_analog: UniProt:Q99LB6
relationship: sequence_of IMR:0002592 ! MAT II beta subunit

[Term]
id: IMR:0002598
name: deoxyribonucleoside kinase
def: "Mammals have four deoxyribonucleoside kinases, the cytoplasmic (TK1) and mitochondrial (TK2) thymidine kinases, and the deoxycytidine (dCK) and deoxyguanosine (dGK) kinases with overlapping substrate specificities. dCK, dGK and TK2 show a high level of amino acid sequence identity; from a phylogenetic point of view, they belong to the same family, whereas TK1 belongs to another family." [PubMed:14609716, PubMed:15896737, PubMed:7494863]
exact_synonym: "dNK" []
is_a: IMR:0002600 ! nucleoside kinase

[Term]
id: IMR:0002599
name: nucleobase, nucleoside, nucleotide kinase
xref_analog: GO:0019205
is_a: IMR:0000512 ! kinase

[Term]
id: IMR:0002600
name: nucleoside kinase
xref_analog: GO:0019206
is_a: IMR:0002599 ! nucleobase, nucleoside, nucleotide kinase

[Term]
id: IMR:0002601
name: uridine-cytidine kinase
def: "Uridine-cytidine kinase (UCK) (EC 2.7.1.48) is a pyrimidine ribonucleoside kinase that catalyzes the phosphorylation of uridine and cytidine to UMP and CMP. Two human UCKs, named UCK1 and UCK2, were cloned." [PubMed:11306702]
xref_analog: EC:2.7.1.48
is_a: IMR:0002600 ! nucleoside kinase

[Term]
id: IMR:0002602
name: creatine kinase
def: "In both mammals and birds, the creatine kinase (CK) family consists of four types of genes: cytosolic brain type (B-CK); cytosolic muscle type (M-CK); mitochondrial ubiquitous, acidic type (Mia-CK); and mitochondrial sarcomeric, basic type (Mib-CK)." [PubMed:8662608]
xref_analog: EC:2.7.3.2
xref_analog: GO:0004111
is_a: IMR:0000512 ! kinase

[Term]
id: IMR:0002603
name: brain creatine kinase
exact_synonym: "B-CK" []
is_a: IMR:0002602 ! creatine kinase

[Term]
id: IMR:0002604
name: muscle creatine kinase
exact_synonym: "M-CK" []
is_a: IMR:0002602 ! creatine kinase

[Term]
id: IMR:0002605
name: acidic type mitochondrial creatine kinase
exact_synonym: "Mia-CK" []
is_a: IMR:0002602 ! creatine kinase

[Term]
id: IMR:0002606
name: basic type mitochondrial creatine kinase
exact_synonym: "Mib-CK" []
is_a: IMR:0002602 ! creatine kinase

[Term]
id: IMR:0002607
name: KCRB_MOUSE
exact_synonym: "B-CK" [UniProt:Q04447, MGI:88407]
exact_synonym: "Ck-3" [MGI:88407]
exact_synonym: "Ckb" [UniProt:Q04447, MGI:88407]
exact_synonym: "Ckbb" [UniProt:Q04447]
exact_synonym: "Creatine kinase B chain" [UniProt:Q04447]
exact_synonym: "Creatine kinase B-type" [UniProt:Q04447]
exact_synonym: "creatine kinase, brain" [MGI:88407]
exact_synonym: "EC 2.7.3.2" [UniProt:Q04447]
xref_analog: UniProt:Q04447
relationship: sequence_of IMR:0002603 ! brain creatine kinase

[Term]
id: IMR:0002608
name: KCRB_RAT
exact_synonym: "B-CK" [UniProt:P07335]
exact_synonym: "Ckb" [RGD:2357, UniProt:P07335]
exact_synonym: "Ckbb" [UniProt:P07335]
exact_synonym: "Creatine kinase B chain" [UniProt:P07335]
exact_synonym: "Creatine kinase B-type" [UniProt:P07335]
exact_synonym: "creatine kinase, brain" [RGD:2357]
exact_synonym: "EC 2.7.3.2" [UniProt:P07335]
xref_analog: UniProt:P07335
relationship: sequence_of IMR:0002603 ! brain creatine kinase

[Term]
id: IMR:0002609
name: KCRM_MOUSE
exact_synonym: "Ckm" [MGI:88413, UniProt:P07310]
exact_synonym: "Ckmm" [MGI:88413, UniProt:P07310]
exact_synonym: "Creatine kinase M chain" [UniProt:P07310]
exact_synonym: "Creatine kinase M-type" [UniProt:P07310]
exact_synonym: "creatine kinase, muscle" [MGI:88413]
exact_synonym: "EC 2.7.3.2" [UniProt:P07310]
exact_synonym: "M-CK" [MGI:88413, UniProt:P07310]
exact_synonym: "MCK" [MGI:88413]
xref_analog: UniProt:P07310
relationship: sequence_of IMR:0002604 ! muscle creatine kinase

[Term]
id: IMR:0002610
name: KCRM_RAT
exact_synonym: "Ckm" [UniProt:P00564, RGD:2358]
exact_synonym: "Ckmm" [UniProt:P00564]
exact_synonym: "Creatine kinase M chain" [UniProt:P00564]
exact_synonym: "Creatine kinase M-type" [UniProt:P00564]
exact_synonym: "creatine kinase, muscle" [RGD:2358]
exact_synonym: "EC 2.7.3.2" [UniProt:P00564]
exact_synonym: "M-CK" [UniProt:P00564]
xref_analog: UniProt:P00564
relationship: sequence_of IMR:0002604 ! muscle creatine kinase

[Term]
id: IMR:0002611
name: KCRU_MOUSE
exact_synonym: "Acidic-type mitochondrial creatine kinase" [UniProt:P30275]
exact_synonym: "Ckmt1" [UniProt:P30275, MGI:99441]
exact_synonym: "Creatine kinase U-type, mitochondrial" [UniProt:P30275]
exact_synonym: "creatine kinase, mitochondrial 1, ubiquitous" [MGI:99441]
exact_synonym: "EC 2.7.3.2" [UniProt:P30275]
exact_synonym: "mi-CK" [MGI:99441]
exact_synonym: "Mia-CK" [UniProt:P30275]
exact_synonym: "Mt-CK" [MGI:99441]
exact_synonym: "U-MtCK" [UniProt:P30275]
exact_synonym: "UbCKmit" [MGI:99441]
exact_synonym: "Ubiquitous mitochondrial creatine kinase" [UniProt:P30275]
xref_analog: UniProt:P30275
relationship: sequence_of IMR:0002605 ! acidic type mitochondrial creatine kinase

[Term]
id: IMR:0002612
name: KCRU_RAT
exact_synonym: "Acidic-type mitochondrial creatine kinase" [UniProt:P25809]
exact_synonym: "Ckmt" [UniProt:P25809]
exact_synonym: "Ckmt1" [RGD:61976, UniProt:P25809]
exact_synonym: "Creatine kinase U-type, mitochondrial" [UniProt:P25809]
exact_synonym: "creatine kinase, mitochondrial 1" [RGD:61976]
exact_synonym: "EC 2.7.3.2" [UniProt:P25809]
exact_synonym: "Mia-CK" [UniProt:P25809]
exact_synonym: "U-MtCK" [UniProt:P25809]
exact_synonym: "Ubiquitous mitochondrial creatine kinase" [UniProt:P25809]
xref_analog: UniProt:P25809
relationship: sequence_of IMR:0002605 ! acidic type mitochondrial creatine kinase

[Term]
id: IMR:0002613
name: KCRS_MOUSE
exact_synonym: "Basic-type mitochondrial creatine kinase" [UniProt:Q6P8J7]
exact_synonym: "Ckmt2" [UniProt:Q6P8J7, MGI:1923972]
exact_synonym: "Creatine kinase S-type, mitochondrial" [UniProt:Q6P8J7]
exact_synonym: "creatine kinase, mitochondrial 2" [MGI:1923972]
exact_synonym: "EC 2.7.3.2" [UniProt:Q6P8J7]
exact_synonym: "Mib-CK" [UniProt:Q6P8J7]
exact_synonym: "S-MtCK" [UniProt:Q6P8J7]
exact_synonym: "Sarcomeric mitochondrial creatine kinase" [UniProt:Q6P8J7]
exact_synonym: "ScCKmit" [MGI:1923972]
xref_analog: UniProt:Q6P8J7
relationship: sequence_of IMR:0002606 ! basic type mitochondrial creatine kinase

[Term]
id: IMR:0002614
name: KCRS_RAT
exact_synonym: "Basic-type mitochondrial creatine kinase" [UniProt:P09605]
exact_synonym: "Ckmt2" [RGD:61977, UniProt:P09605]
exact_synonym: "Creatine kinase S-type, mitochondrial" [UniProt:P09605]
exact_synonym: "creatine kinase, mitochondrial 2, sarcomeric" [RGD:61977]
exact_synonym: "EC 2.7.3.2" [UniProt:P09605]
exact_synonym: "Mib-CK" [UniProt:P09605]
exact_synonym: "S-MtCK" [UniProt:P09605]
exact_synonym: "Sarcomeric mitochondrial creatine kinase" [UniProt:P09605]
xref_analog: UniProt:P09605
relationship: sequence_of IMR:0002606 ! basic type mitochondrial creatine kinase

[Term]
id: IMR:0002615
name: NPP
def: "The family of nucleotide pyrophosphatases/phosphodiesterases (NPPs) consists of seven structurally related ecto-enzymes that are numbered according to their order of discovery." [PubMed:16125936]
exact_synonym: "E-NPP" []
exact_synonym: "ecto-nucleotide pyrophosphatase/phosphodiesterase" []
exact_synonym: "nucleotide pyrophosphatase/phosphodiesterase" []
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0002616
name: NPP1
is_a: IMR:0002615 ! NPP

[Term]
id: IMR:0002617
name: NPP2
is_a: IMR:0002615 ! NPP

[Term]
id: IMR:0002618
name: NPP3
is_a: IMR:0002615 ! NPP

[Term]
id: IMR:0002619
name: NPP4
is_a: IMR:0002615 ! NPP

[Term]
id: IMR:0002620
name: NPP5
is_a: IMR:0002615 ! NPP

[Term]
id: IMR:0002621
name: NPP6
is_a: IMR:0002615 ! NPP

[Term]
id: IMR:0002622
name: NPP7
is_a: IMR:0002615 ! NPP

[Term]
id: IMR:0002623
name: ENPP1_MOUSE
exact_synonym: "Alkaline phosphodiesterase I" [UniProt:P06802]
exact_synonym: "CD203c" [MGI:97370]
exact_synonym: "E-NPP 1" [UniProt:P06802]
exact_synonym: "E-NPP1" [MGI:97370]
exact_synonym: "EC 3.1.4.1" [UniProt:P06802]
exact_synonym: "EC 3.6.1.9" [UniProt:P06802]
exact_synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 1" [MGI:97370]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase family member 1" [UniProt:P06802]
exact_synonym: "Enpp1" [MGI:97370, UniProt:P06802]
exact_synonym: "Ly-41" [MGI:97370, UniProt:P06802]
exact_synonym: "Lymphocyte antigen 41" [UniProt:P06802]
exact_synonym: "NPP1" [MGI:97370]
exact_synonym: "NPPase" [UniProt:P06802]
exact_synonym: "Npps" [MGI:97370, UniProt:P06802]
exact_synonym: "Nucleotide pyrophosphatase" [UniProt:P06802]
exact_synonym: "PC-1" [MGI:97370]
exact_synonym: "Pc1" [UniProt:P06802]
exact_synonym: "Pca" [MGI:97370]
exact_synonym: "Pca-1" [MGI:97370]
exact_synonym: "Pdnp1" [MGI:97370, UniProt:P06802]
exact_synonym: "Phosphodiesterase I/nucleotide pyrophosphatase 1" [UniProt:P06802]
exact_synonym: "Plasma-cell membrane glycoprotein PC-1" [UniProt:P06802]
exact_synonym: "twy" [MGI:97370]
xref_analog: UniProt:P06802
relationship: sequence_of IMR:0002616 ! NPP1

[Term]
id: IMR:0002624
name: ENPP1_RAT
exact_synonym: "Alkaline phosphodiesterase I" [UniProt:Q924C3]
exact_synonym: "E-NPP 1" [UniProt:Q924C3]
exact_synonym: "EC 3.1.4.1" [UniProt:Q924C3]
exact_synonym: "EC 3.6.1.9" [UniProt:Q924C3]
exact_synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 1" [RGD:628825]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase family member 1" [UniProt:Q924C3]
exact_synonym: "Enpp1" [UniProt:Q924C3, RGD:628825]
exact_synonym: "NPPase" [UniProt:Q924C3]
exact_synonym: "Npps" [UniProt:Q924C3]
exact_synonym: "Nucleotide pyrophosphatase" [UniProt:Q924C3]
exact_synonym: "Pc1" [UniProt:Q924C3]
exact_synonym: "Pdnp1" [UniProt:Q924C3]
exact_synonym: "Phosphodiesterase I/nucleotide pyrophosphatase 1" [UniProt:Q924C3]
exact_synonym: "Plasma-cell membrane glycoprotein PC-1" [UniProt:Q924C3]
xref_analog: UniProt:Q924C3
relationship: sequence_of IMR:0002616 ! NPP1

[Term]
id: IMR:0002625
name: ENPP2_MOUSE
exact_synonym: "ATX" [MGI:1321390]
exact_synonym: "Autotaxin" [MGI:1321390, UniProt:Q9R1E6]
exact_synonym: "E-NPP 2" [UniProt:Q9R1E6]
exact_synonym: "EC 3.1.4.39" [UniProt:Q9R1E6]
exact_synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 2" [MGI:1321390]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase family member 2" [UniProt:Q9R1E6]
exact_synonym: "Enpp2" [MGI:1321390, UniProt:Q9R1E6]
exact_synonym: "Extracellular lysophospholipase D" [UniProt:Q9R1E6]
exact_synonym: "LysoPLD" [UniProt:Q9R1E6]
exact_synonym: "Npps2" [MGI:1321390, UniProt:Q9R1E6]
exact_synonym: "PD-Ialpha" [MGI:1321390]
exact_synonym: "Pdnp2" [MGI:1321390, UniProt:Q9R1E6]
xref_analog: UniProt:Q9R1E6
relationship: sequence_of IMR:0002617 ! NPP2

[Term]
id: IMR:0002626
name: ENPP2_RAT
exact_synonym: "Atx" [UniProt:Q64610]
exact_synonym: "Autotaxin" [UniProt:Q64610]
exact_synonym: "E-NPP 2" [UniProt:Q64610]
exact_synonym: "EC 3.1.4.39" [UniProt:Q64610]
exact_synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 2" [RGD:69298]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase family member 2" [UniProt:Q64610]
exact_synonym: "Enpp2" [RGD:69298, UniProt:Q64610]
exact_synonym: "Extracellular lysophospholipase D" [UniProt:Q64610]
exact_synonym: "LysoPLD" [UniProt:Q64610]
exact_synonym: "Npps2" [UniProt:Q64610]
xref_analog: UniProt:Q64610
relationship: sequence_of IMR:0002617 ! NPP2

[Term]
id: IMR:0002627
name: ENPP3_MOUSE
exact_synonym: "Alkaline phosphodiesterase I" [UniProt:Q6DYE8]
exact_synonym: "CD203c" [MGI:2143702, UniProt:Q6DYE8]
exact_synonym: "E-NPP 3" [UniProt:Q6DYE8]
exact_synonym: "EC 3.1.4.1" [UniProt:Q6DYE8]
exact_synonym: "EC 3.6.1.9" [UniProt:Q6DYE8]
exact_synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 3" [MGI:2143702]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase family member 3" [UniProt:Q6DYE8]
exact_synonym: "Enpp3" [MGI:2143702, UniProt:Q6DYE8]
exact_synonym: "NPPase" [UniProt:Q6DYE8]
exact_synonym: "Nucleotide pyrophosphatase" [UniProt:Q6DYE8]
exact_synonym: "PD-Ibeta" [UniProt:Q6DYE8]
exact_synonym: "Phosphodiesterase I beta" [UniProt:Q6DYE8]
exact_synonym: "Phosphodiesterase I/nucleotide pyrophosphatase 3" [UniProt:Q6DYE8]
xref_analog: UniProt:Q6DYE8
relationship: sequence_of IMR:0002618 ! NPP3

[Term]
id: IMR:0002628
name: ENPP3_RAT
exact_synonym: "Alkaline phosphodiesterase I" [UniProt:P97675]
exact_synonym: "B10" [UniProt:P97675]
exact_synonym: "CD203c" [UniProt:P97675]
exact_synonym: "E-NPP 3" [UniProt:P97675]
exact_synonym: "EC 3.1.4.1" [UniProt:P97675]
exact_synonym: "EC 3.6.1.9" [UniProt:P97675]
exact_synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 3" [RGD:708511]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase family member 3" [UniProt:P97675]
exact_synonym: "Enpp3" [UniProt:P97675, RGD:708511]
exact_synonym: "NPPase" [UniProt:P97675]
exact_synonym: "Nucleotide pyrophosphatase" [UniProt:P97675]
exact_synonym: "PD-Ibeta" [UniProt:P97675]
exact_synonym: "Pdnp3" [UniProt:P97675]
exact_synonym: "Phosphodiesterase I beta" [UniProt:P97675]
exact_synonym: "Phosphodiesterase I/nucleotide pyrophosphatase 3" [UniProt:P97675]
exact_synonym: "RB13-6 antigen" [UniProt:P97675]
xref_analog: UniProt:P97675
relationship: sequence_of IMR:0002618 ! NPP3

[Term]
id: IMR:0002629
name: ENPP4_HUMAN
exact_synonym: "E-NPP 4" [UniProt:Q9Y6X5]
exact_synonym: "EC 3.1.-.-" [UniProt:Q9Y6X5]
exact_synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)" [HGNC:3359, EntrezGene:22875]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase family member 4" [UniProt:Q9Y6X5]
exact_synonym: "ENPP4" [HGNC:3359, EntrezGene:22875, UniProt:Q9Y6X5]
exact_synonym: "KIAA0879" [HGNC:3359, EntrezGene:22875, UniProt:Q9Y6X5]
exact_synonym: "NPP-4" [UniProt:Q9Y6X5]
exact_synonym: "NPP4" [HGNC:3359, EntrezGene:22875, UniProt:Q9Y6X5]
xref_analog: UniProt:Q9Y6X5
relationship: sequence_of IMR:0002619 ! NPP4

[Term]
id: IMR:0002630
name: ENPP4_MOUSE
exact_synonym: "E-NPP 4" [UniProt:Q8BTJ4]
exact_synonym: "EC 3.1.-.-" [UniProt:Q8BTJ4]
exact_synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 4" [MGI:2682634]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase family member 4" [UniProt:Q8BTJ4]
exact_synonym: "Enpp4" [UniProt:Q8BTJ4, MGI:2682634]
exact_synonym: "Kiaa0879" [UniProt:Q8BTJ4]
exact_synonym: "LOC224794" [MGI:2682634]
exact_synonym: "NPP-4" [UniProt:Q8BTJ4]
xref_analog: UniProt:Q8BTJ4
relationship: sequence_of IMR:0002619 ! NPP4

[Term]
id: IMR:0002631
name: ENPP5_HUMAN
exact_synonym: "E-NPP 5" [UniProt:Q9UJA9]
exact_synonym: "EC 3.1.-.-" [UniProt:Q9UJA9]
exact_synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)" [EntrezGene:59084, HGNC:13717]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase family member 5" [UniProt:Q9UJA9]
exact_synonym: "ENPP5" [EntrezGene:59084, HGNC:13717, UniProt:Q9UJA9]
exact_synonym: "KIAA0879" [EntrezGene:59084]
exact_synonym: "NPP-5" [UniProt:Q9UJA9]
xref_analog: UniProt:Q9UJA9
relationship: sequence_of IMR:0002620 ! NPP5

[Term]
id: IMR:0002632
name: ENPP5_MOUSE
exact_synonym: "D17Abb1e" [MGI:1933830]
exact_synonym: "E-NPP 5" [UniProt:Q9EQG7]
exact_synonym: "EC 3.1.-.-" [UniProt:Q9EQG7]
exact_synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 5" [MGI:1933830]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase family member 5" [UniProt:Q9EQG7]
exact_synonym: "Enpp5" [UniProt:Q9EQG7, MGI:1933830]
exact_synonym: "NPP-5" [UniProt:Q9EQG7]
xref_analog: UniProt:Q9EQG7
relationship: sequence_of IMR:0002620 ! NPP5

[Term]
id: IMR:0002633
name: ENPP5_RAT
exact_synonym: "E-NPP 5" [UniProt:P84039]
exact_synonym: "EC 3.1.-.-" [UniProt:P84039]
exact_synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 5" [RGD:1359199]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase family member 5" [UniProt:P84039]
exact_synonym: "Enpp5" [RGD:1359199, UniProt:P84039]
exact_synonym: "NPP-5" [UniProt:P84039]
xref_analog: UniProt:P84039
relationship: sequence_of IMR:0002620 ! NPP5

[Term]
id: IMR:0002634
name: ENPP6_HUMAN
exact_synonym: "E-NPP 6" [UniProt:Q6UWR7]
exact_synonym: "EC 3.1.-.-" [UniProt:Q6UWR7]
exact_synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 6" [EntrezGene:133121, HGNC:23409]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase family member 6" [UniProt:Q6UWR7]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 soluble form" [UniProt:Q6UWR7]
exact_synonym: "ENPP6" [UniProt:Q6UWR7, EntrezGene:133121, HGNC:23409]
exact_synonym: "MGC33971" [EntrezGene:133121, HGNC:23409]
exact_synonym: "NPP-6" [UniProt:Q6UWR7]
exact_synonym: "NPP6" [EntrezGene:133121]
xref_analog: UniProt:Q6UWR7
relationship: sequence_of IMR:0002621 ! NPP6

[Term]
id: IMR:0002635
name: ENPP6_MOUSE
exact_synonym: "D8Ertd514e" [MGI:2445171]
exact_synonym: "E-NPP 6" [UniProt:Q8BGN3]
exact_synonym: "EC 3.1.-.-" [UniProt:Q8BGN3]
exact_synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 6" [MGI:2445171]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase family member 6" [UniProt:Q8BGN3]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 soluble form" [UniProt:Q8BGN3]
exact_synonym: "Enpp6" [MGI:2445171, UniProt:Q8BGN3]
exact_synonym: "NPP-6" [UniProt:Q8BGN3]
exact_synonym: "Npp6" [MGI:2445171]
xref_analog: UniProt:Q8BGN3
relationship: sequence_of IMR:0002621 ! NPP6

[Term]
id: IMR:0002636
name: ENPP7_HUMAN
exact_synonym: "Alk-SMase" [UniProt:Q6UWV6]
exact_synonym: "alk-SMase" [HGNC:23764]
exact_synonym: "ALK-SMase" [EntrezGene:339221]
exact_synonym: "Alkaline sphingomyelin phosphodiesterase" [UniProt:Q6UWV6]
exact_synonym: "E-NPP 7" [UniProt:Q6UWV6]
exact_synonym: "EC 3.1.4.12" [UniProt:Q6UWV6]
exact_synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 7" [HGNC:23764, EntrezGene:339221]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase family member 7" [UniProt:Q6UWV6]
exact_synonym: "ENPP7" [HGNC:23764, EntrezGene:339221, UniProt:Q6UWV6]
exact_synonym: "Intestinal alkaline sphingomyelinase" [UniProt:Q6UWV6]
exact_synonym: "MGC50179" [EntrezGene:339221]
exact_synonym: "NPP-7" [UniProt:Q6UWV6]
xref_analog: UniProt:Q6UWV6
relationship: sequence_of IMR:0002622 ! NPP7

[Term]
id: IMR:0002637
name: A2A5N7_MOUSE
exact_synonym: "Alk-SMase" [MGI:3027917]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase 7" [UniProt:A2A5N7]
exact_synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 7" [MGI:3027917]
exact_synonym: "Enpp7" [MGI:3027917, UniProt:A2A5N7]
exact_synonym: "LOC238011" [MGI:3027917]
xref_analog: UniProt:A2A5N7
relationship: sequence_of IMR:0002622 ! NPP7

[Term]
id: IMR:0002638
name: ENPP7_RAT
exact_synonym: "Alk-SMase" [UniProt:Q5EZ72]
exact_synonym: "Alkaline sphingomyelin phosphodiesterase" [UniProt:Q5EZ72]
exact_synonym: "E-NPP 7" [UniProt:Q5EZ72]
exact_synonym: "EC 3.1.4.12" [UniProt:Q5EZ72]
exact_synonym: "ectonucleotide pyrophosphatase/phosphodiesterase 7" [RGD:1359324]
exact_synonym: "Ectonucleotide pyrophosphatase/phosphodiesterase family member 7" [UniProt:Q5EZ72]
exact_synonym: "Enpp7" [UniProt:Q5EZ72, RGD:1359324]
exact_synonym: "Intestinal alkaline sphingomyelinase" [UniProt:Q5EZ72]
exact_synonym: "NPP-7" [UniProt:Q5EZ72]
xref_analog: UniProt:Q5EZ72
relationship: sequence_of IMR:0002622 ! NPP7

[Term]
id: IMR:0002639
name: S-adenosylhomocysteine hydrolase
exact_synonym: "AdoHcyase" []
xref_analog: EC:3.3.1.1
xref_analog: GO:0004013
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0002640
name: cytochrome P450
is_a: IMR:0000952 ! oxidoreductase

[Term]
id: IMR:0002641
name: c-FLIP
is_a: IMR:0000450 ! apoptosis regulator

[Term]
id: IMR:0002642
name: Daxx
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0002643
name: DAXX_HUMAN
exact_synonym: "BING2" [MIM:603186, EntrezGene:1616, UniProt:Q9UER7]
exact_synonym: "DAP6" [HGNC:2681, EntrezGene:1616, UniProt:Q9UER7]
exact_synonym: "Daxx" [MIM:603186, UniProt:Q9UER7]
exact_synonym: "DAXX" [HGNC:2681, EntrezGene:1616, UniProt:Q9UER7]
exact_synonym: "Death domain-associated protein 6" [UniProt:Q9UER7]
exact_synonym: "DEATH-ASSOCIATED PROTEIN 6" [MIM:603186]
exact_synonym: "death-domain associated protein" [HGNC:2681, EntrezGene:1616]
exact_synonym: "EAP1" [EntrezGene:1616, UniProt:Q9UER7]
exact_synonym: "ETS1-associated protein 1" [UniProt:Q9UER7]
exact_synonym: "Fas death domain-associated protein" [UniProt:Q9UER7]
exact_synonym: "hDaxx" [UniProt:Q9UER7]
exact_synonym: "MGC126245" [EntrezGene:1616]
exact_synonym: "MGC126246" [EntrezGene:1616]
xref_analog: UniProt:Q9UER7
relationship: sequence_of IMR:0002642 ! Daxx

[Term]
id: IMR:0002644
name: DAXX_MOUSE
exact_synonym: "Daxx" [MGI:1197015, UniProt:O35613]
exact_synonym: "Death domain-associated protein 6" [UniProt:O35613]
exact_synonym: "Fas death domain-associated protein" [MGI:1197015]
xref_analog: UniProt:O35613
relationship: sequence_of IMR:0002642 ! Daxx

[Term]
id: IMR:0002645
name: DAXX_RAT
exact_synonym: "Daxx" [RGD:621227, UniProt:Q8VIB2]
exact_synonym: "Death domain-associated protein 6" [UniProt:Q8VIB2]
exact_synonym: "death-domain associated protein" [RGD:621227]
xref_analog: UniProt:Q8VIB2
relationship: sequence_of IMR:0002642 ! Daxx

[Term]
id: IMR:0002646
name: CFLAR_MOUSE
exact_synonym: "c-FLIP" [UniProt:O35732]
exact_synonym: "c-Flip" [MGI:1336166]
exact_synonym: "Cash" [MGI:1336166, UniProt:O35732]
exact_synonym: "CASH" [UniProt:O35732]
exact_synonym: "CASP8 and FADD-like apoptosis regulator" [MGI:1336166, UniProt:O35732]
exact_synonym: "CASP8 and FADD-like apoptosis regulator subunit p12" [UniProt:O35732]
exact_synonym: "CASP8 and FADD-like apoptosis regulator subunit p43" [UniProt:O35732]
exact_synonym: "Caspase homolog" [UniProt:O35732]
exact_synonym: "Caspase-eight-related protein" [UniProt:O35732]
exact_synonym: "Caspase-like apoptosis regulatory protein" [UniProt:O35732]
exact_synonym: "Casper" [MGI:1336166, UniProt:O35732]
exact_synonym: "Cellular FLICE-like inhibitory protein" [UniProt:O35732]
exact_synonym: "Cflar" [MGI:1336166, UniProt:O35732]
exact_synonym: "CLARP" [UniProt:O35732]
exact_synonym: "FADD-like antiapoptotic molecule 1" [UniProt:O35732]
exact_synonym: "FLAME-1" [UniProt:O35732]
exact_synonym: "Flip" [MGI:1336166]
exact_synonym: "I-FLICE" [UniProt:O35732]
exact_synonym: "Inhibitor of FLICE" [UniProt:O35732]
exact_synonym: "MACH-related inducer of toxicity" [UniProt:O35732]
exact_synonym: "MRIT" [UniProt:O35732]
exact_synonym: "Usurpin" [UniProt:O35732]
xref_analog: UniProt:O35732
relationship: sequence_of IMR:0002641 ! c-FLIP

[Term]
id: IMR:0002647
name: DHSA_MOUSE
exact_synonym: "EC 1.3.5.1" [UniProt:Q8K2B3]
exact_synonym: "Flavoprotein subunit of complex II" [UniProt:Q8K2B3]
exact_synonym: "Fp" [UniProt:Q8K2B3]
exact_synonym: "FP" [MGI:1914195]
exact_synonym: "SDH2" [MGI:1914195]
exact_synonym: "Sdha" [UniProt:Q8K2B3, MGI:1914195]
exact_synonym: "SDHF" [MGI:1914195]
exact_synonym: "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial" [UniProt:Q8K2B3]
exact_synonym: "succinate dehydrogenase complex, subunit A, flavoprotein (Fp)" [MGI:1914195]
xref_analog: UniProt:Q8K2B3
relationship: sequence_of IMR:0010210 ! SDHA

[Term]
id: IMR:0002648
name: DHSB_MOUSE
exact_synonym: "EC 1.3.5.1" [UniProt:Q9CQA3]
exact_synonym: "Ip" [UniProt:Q9CQA3]
exact_synonym: "Iron-sulfur subunit of complex II" [UniProt:Q9CQA3]
exact_synonym: "Sdhb" [UniProt:Q9CQA3, MGI:1914930]
exact_synonym: "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial" [UniProt:Q9CQA3]
exact_synonym: "succinate dehydrogenase complex, subunit B, iron sulfur (Ip)" [MGI:1914930]
xref_analog: UniProt:Q9CQA3
relationship: sequence_of IMR:0010211 ! SDHB

[Term]
id: IMR:0002649
name: C560_MOUSE
exact_synonym: "Integral membrane protein CII-3" [UniProt:Q9CZB0]
exact_synonym: "QPs-1" [UniProt:Q9CZB0]
exact_synonym: "QPs1" [UniProt:Q9CZB0]
exact_synonym: "Sdhc" [MGI:1913302, UniProt:Q9CZB0]
exact_synonym: "succinate dehydrogenase complex, subunit C, integral membrane protein" [MGI:1913302]
exact_synonym: "Succinate dehydrogenase cytochrome b560 subunit, mitochondrial" [UniProt:Q9CZB0]
xref_analog: UniProt:Q9CZB0
relationship: sequence_of IMR:0010171 ! SDHC

[Term]
id: IMR:0002650
name: DHSD_MOUSE
exact_synonym: "CII-4" [UniProt:Q9CXV1]
exact_synonym: "CybS" [UniProt:Q9CXV1]
exact_synonym: "QPs3" [UniProt:Q9CXV1]
exact_synonym: "Sdhd" [MGI:1914175, UniProt:Q9CXV1]
exact_synonym: "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial" [UniProt:Q9CXV1]
exact_synonym: "Succinate dehydrogenase complex subunit D" [UniProt:Q9CXV1]
exact_synonym: "succinate dehydrogenase complex, subunit D, integral membrane protein" [MGI:1914175]
exact_synonym: "Succinate-ubiquinone oxidoreductase cytochrome b small subunit" [UniProt:Q9CXV1]
exact_synonym: "Succinate-ubiquinone reductase membrane anchor subunit" [UniProt:Q9CXV1]
xref_analog: UniProt:Q9CXV1
relationship: sequence_of IMR:0010212 ! SDHD

[Term]
id: IMR:0002651
name: DHSD_RAT
exact_synonym: "CII-4" [UniProt:Q6PCT8]
exact_synonym: "CybS" [UniProt:Q6PCT8]
exact_synonym: "QPs3" [UniProt:Q6PCT8]
exact_synonym: "Sdhd" [UniProt:Q6PCT8, RGD:735231]
exact_synonym: "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial" [UniProt:Q6PCT8]
exact_synonym: "Succinate dehydrogenase complex subunit D" [UniProt:Q6PCT8]
exact_synonym: "succinate dehydrogenase complex, subunit D, integral membrane protein" [RGD:735231]
exact_synonym: "Succinate-ubiquinone oxidoreductase cytochrome b small subunit" [UniProt:Q6PCT8]
exact_synonym: "Succinate-ubiquinone reductase membrane anchor subunit" [UniProt:Q6PCT8]
xref_analog: UniProt:Q6PCT8
relationship: sequence_of IMR:0010212 ! SDHD

[Term]
id: IMR:0002652
name: CD39/NTPDase family
def: "The NTPDase family of enzymes includes eight enzymes. CD39/NTPDase1 hydrolyzes both ATP and ADP, while other members of the NTPDase family preferentially hydrolyze ATP or ADP." [PubMed:16476557, PubMed:9676740]
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0002653
name: pyruvate dehydrogenase
def: "Mammalian pyruvate dehydrogenase (PDH) is a tetramer consisting of two alpha and two beta subunits. PDH alpha subunit is encoded by two genes as follows: PDHA1 is expressed in somatic cells and PDHA2 is expressed in testis only. PDH beta subunit is encoded by PDHB and is common to PDH in somatic and testicular cells." [PubMed:16436377]
exact_synonym: "E1" []
exact_synonym: "PDH" []
xref_analog: EC:1.2.4.1
is_a: IMR:0010047 ! dehydrogenase
relationship: part_of IMR:0001002 ! pyruvate dehydrogenase complex

[Term]
id: IMR:0002654
name: pyruvate dehydrogenase alpha subunit, testis-specific form
exact_synonym: "E1 alpha subunit, testis-specific form" []
exact_synonym: "PDHA2" []
is_a: IMR:0002653 ! pyruvate dehydrogenase

[Term]
id: IMR:0002655
name: CARMA1
exact_synonym: "CARD/MAGUK1" []
exact_synonym: "CARD11" []
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0002656
name: CAR11_HUMAN
exact_synonym: "BCL10-INTERACTING MAGUK PROTEIN 3" [MIM:607210]
exact_synonym: "BIMP3" [MIM:607210, HGNC:16393, EntrezGene:84433]
exact_synonym: "CARD-containing MAGUK protein 1" [UniProt:Q9BXL7]
exact_synonym: "CARD-MAGUK PROTEIN 1" [MIM:607210]
exact_synonym: "CARD11" [MIM:607210, HGNC:16393, UniProt:Q9BXL7, EntrezGene:84433]
exact_synonym: "Carma 1" [UniProt:Q9BXL7]
exact_synonym: "CARMA1" [MIM:607210, HGNC:16393, UniProt:Q9BXL7, EntrezGene:84433]
exact_synonym: "caspase recruitment domain family, member 11" [HGNC:16393, EntrezGene:84433]
exact_synonym: "Caspase recruitment domain-containing protein 11" [MIM:607210, UniProt:Q9BXL7]
exact_synonym: "MGC133069" [EntrezGene:84433]
xref_analog: UniProt:Q9BXL7
relationship: sequence_of IMR:0002655 ! CARMA1

[Term]
id: IMR:0002657
name: Q8BVX8_MOUSE
exact_synonym: "BIMP3" [MGI:1916978]
exact_synonym: "Card11" [MGI:1916978, UniProt:Q8BVX8]
exact_synonym: "CARMA1" [MGI:1916978]
exact_synonym: "caspase recruitment domain family, member 11" [MGI:1916978]
exact_synonym: "Putative uncharacterized protein" [UniProt:Q8BVX8]
xref_analog: UniProt:Q8BVX8
relationship: sequence_of IMR:0002655 ! CARMA1

[Term]
id: IMR:0002658
name: BCL10
exact_synonym: "c-E10" []
exact_synonym: "CARMEN" []
exact_synonym: "CIPER" []
exact_synonym: "CLAP" []
exact_synonym: "mE10" []
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0002659
name: BCL10_HUMAN
exact_synonym: "B-cell CLL/lymphoma 10" [MIM:603517, HGNC:989, EntrezGene:8915, UniProt:O95999]
exact_synonym: "B-CELL LEUKEMIA/LYMPHOMA 10" [MIM:603517]
exact_synonym: "B-cell lymphoma/leukemia 10" [UniProt:O95999]
exact_synonym: "Bcl-10" [UniProt:O95999]
exact_synonym: "BCL10" [MIM:603517, HGNC:989, EntrezGene:8915, UniProt:O95999]
exact_synonym: "c-E10" [HGNC:989, EntrezGene:8915, UniProt:O95999]
exact_synonym: "CARD-containing molecule enhancing NF-kappa-B" [UniProt:O95999]
exact_synonym: "CARD-like apoptotic protein" [UniProt:O95999]
exact_synonym: "CARMEN" [HGNC:989, EntrezGene:8915]
exact_synonym: "cCARMEN" [UniProt:O95999]
exact_synonym: "CED-3/ICH-1 prodomain homologous E10-like regulator" [UniProt:O95999]
exact_synonym: "Cellular homolog of vCARMEN" [UniProt:O95999]
exact_synonym: "Cellular-E10" [UniProt:O95999]
exact_synonym: "CIPER" [HGNC:989, EntrezGene:8915, UniProt:O95999]
exact_synonym: "CLAP" [HGNC:989, EntrezGene:8915, UniProt:O95999]
exact_synonym: "hCLAP" [UniProt:O95999]
exact_synonym: "Mammalian CARD-containing adapter molecule E10" [UniProt:O95999]
exact_synonym: "mE10" [HGNC:989, EntrezGene:8915, UniProt:O95999]
xref_analog: UniProt:O95999
relationship: sequence_of IMR:0002658 ! BCL10

[Term]
id: IMR:0002660
name: BCL10_MOUSE
exact_synonym: "B-cell CLL/lymphoma 10" [UniProt:Q9Z0H7]
exact_synonym: "B-cell leukemia/lymphoma 10" [MGI:1337994]
exact_synonym: "B-cell lymphoma/leukemia 10" [UniProt:Q9Z0H7]
exact_synonym: "Bcl-10" [UniProt:Q9Z0H7]
exact_synonym: "BCL-10" [MGI:1337994]
exact_synonym: "Bcl10" [MGI:1337994, UniProt:Q9Z0H7]
exact_synonym: "c-E10" [UniProt:Q9Z0H7]
exact_synonym: "CARD-containing molecule enhancing NF-kappa-B" [UniProt:Q9Z0H7]
exact_synonym: "CARD-like apoptotic protein" [UniProt:Q9Z0H7]
exact_synonym: "cCARMEN" [UniProt:Q9Z0H7]
exact_synonym: "cE10" [MGI:1337994]
exact_synonym: "CED-3/ICH-1 prodomain homologous E10-like regulator" [UniProt:Q9Z0H7]
exact_synonym: "Cellular homolog of vCARMEN" [UniProt:Q9Z0H7]
exact_synonym: "Cellular-E10" [UniProt:Q9Z0H7]
exact_synonym: "Ciper" [UniProt:Q9Z0H7]
exact_synonym: "Clap" [UniProt:Q9Z0H7]
exact_synonym: "Mammalian CARD-containing adapter molecule E10" [UniProt:Q9Z0H7]
exact_synonym: "mCIPER" [UniProt:Q9Z0H7]
exact_synonym: "mCLAP" [UniProt:Q9Z0H7]
exact_synonym: "mE10" [MGI:1337994, UniProt:Q9Z0H7]
xref_analog: UniProt:Q9Z0H7
relationship: sequence_of IMR:0002658 ! BCL10

[Term]
id: IMR:0002661
name: BCL10_RAT
exact_synonym: "B-cell CLL/lymphoma 10" [UniProt:Q9QYN5, RGD:620544]
exact_synonym: "B-cell lymphoma/leukemia 10" [UniProt:Q9QYN5]
exact_synonym: "Bcl-10" [UniProt:Q9QYN5]
exact_synonym: "Bcl10" [UniProt:Q9QYN5, RGD:620544]
exact_synonym: "R-RCD1" [UniProt:Q9QYN5]
exact_synonym: "RCD" [UniProt:Q9QYN5]
xref_analog: UniProt:Q9QYN5
relationship: sequence_of IMR:0002658 ! BCL10

[Term]
id: IMR:0002662
name: MALT1
exact_synonym: "paracaspase" []
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0002663
name: MALT1_HUMAN
exact_synonym: "DKFZp434L132" [EntrezGene:10892]
exact_synonym: "EC 3.4.22.-" [UniProt:Q9UDY8]
exact_synonym: "MALT lymphoma-associated translocation" [UniProt:Q9UDY8]
exact_synonym: "MALT1" [MIM:604860, UniProt:Q9UDY8, EntrezGene:10892, HGNC:6819]
exact_synonym: "MLT" [MIM:604860, UniProt:Q9UDY8, EntrezGene:10892]
exact_synonym: "MLT1" [EntrezGene:10892]
exact_synonym: "mucosa associated lymphoid tissue lymphoma translocation gene 1" [EntrezGene:10892, HGNC:6819]
exact_synonym: "MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION GENE 1" [MIM:604860]
exact_synonym: "Mucosa-associated lymphoid tissue lymphoma translocation protein 1" [UniProt:Q9UDY8]
exact_synonym: "Paracaspase" [MIM:604860, UniProt:Q9UDY8]
xref_analog: UniProt:Q9UDY8
relationship: sequence_of IMR:0002662 ! MALT1

[Term]
id: IMR:0002664
name: MALT1_MOUSE
exact_synonym: "EC 3.4.22.-" [UniProt:Q2TBA3]
exact_synonym: "Malt1" [UniProt:Q2TBA3, MGI:2445027]
exact_synonym: "mucosa associated lymphoid tissue lymphoma translocation gene 1" [MGI:2445027]
exact_synonym: "Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog" [UniProt:Q2TBA3]
exact_synonym: "Paracaspase" [UniProt:Q2TBA3]
exact_synonym: "paracaspase" [MGI:2445027]
xref_analog: UniProt:Q2TBA3
relationship: sequence_of IMR:0002662 ! MALT1

[Term]
id: IMR:0002665
name: TAB
exact_synonym: "TAK1-binding protein" []
is_a: IMR:0000429 ! enzyme regulator

[Term]
id: IMR:0002666
name: TAB3
exact_synonym: "TAK1-binding protein-3" []
is_a: IMR:0002665 ! TAB

[Term]
id: IMR:0002667
name: TAB1_MOUSE
exact_synonym: "Map3k7ip1" [UniProt:Q8CF89, MGI:1913763]
exact_synonym: "Mitogen-activated protein kinase kinase kinase 7-interacting protein 1" [UniProt:Q8CF89]
exact_synonym: "Tab1" [UniProt:Q8CF89, MGI:1913763]
exact_synonym: "TAK1-binding protein 1" [UniProt:Q8CF89]
exact_synonym: "Tak1-binding protein 1" [MGI:1913763]
exact_synonym: "TGF-beta activated kinase 1/MAP3K7 binding protein 1" [MGI:1913763]
exact_synonym: "TGF-beta-activated kinase 1 and MAP3K7-binding protein 1" [UniProt:Q8CF89]
exact_synonym: "TGF-beta-activated kinase 1-binding protein 1" [UniProt:Q8CF89]
xref_analog: UniProt:Q8CF89
relationship: sequence_of IMR:0000441 ! TAB1

[Term]
id: IMR:0002668
name: TAB2_MOUSE
exact_synonym: "Kiaa0733" [UniProt:Q99K90]
exact_synonym: "Map3k7ip2" [MGI:1915902, UniProt:Q99K90]
exact_synonym: "Mitogen-activated protein kinase kinase kinase 7-interacting protein 2" [UniProt:Q99K90]
exact_synonym: "TAB-2" [UniProt:Q99K90]
exact_synonym: "Tab2" [MGI:1915902, UniProt:Q99K90]
exact_synonym: "Tak1 binding protein 2" [MGI:1915902]
exact_synonym: "TAK1-binding protein 2" [UniProt:Q99K90]
exact_synonym: "TGF-beta activated kinase 1/MAP3K7 binding protein 2" [MGI:1915902]
exact_synonym: "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2" [UniProt:Q99K90]
exact_synonym: "TGF-beta-activated kinase 1-binding protein 2" [UniProt:Q99K90]
xref_analog: UniProt:Q99K90
relationship: sequence_of IMR:0000893 ! TAB2

[Term]
id: IMR:0002669
name: TAB3_HUMAN
exact_synonym: "MAP3K7IP3" [EntrezGene:257397, UniProt:Q8N5C8]
exact_synonym: "MGC45404" [EntrezGene:257397]
exact_synonym: "Mitogen-activated protein kinase kinase kinase 7-interacting protein 3" [UniProt:Q8N5C8]
exact_synonym: "NAP1" [EntrezGene:257397]
exact_synonym: "NF-kappa-B-activating protein 1" [UniProt:Q8N5C8]
exact_synonym: "TAB-3" [UniProt:Q8N5C8]
exact_synonym: "TAB3" [MIM:300480, HGNC:30681, EntrezGene:257397, UniProt:Q8N5C8]
exact_synonym: "TAK1-binding protein 3" [MIM:300480, UniProt:Q8N5C8]
exact_synonym: "TGF-beta activated kinase 1/MAP3K7 binding protein 3" [HGNC:30681, EntrezGene:257397]
exact_synonym: "TGF-beta-activated kinase 1 and MAP3K7-binding protein 3" [UniProt:Q8N5C8]
exact_synonym: "TGF-beta-activated kinase 1-binding protein 3" [UniProt:Q8N5C8]
xref_analog: UniProt:Q8N5C8
relationship: sequence_of IMR:0002666 ! TAB3

[Term]
id: IMR:0002670
name: TAB3_MOUSE
exact_synonym: "Kiaa4135" [UniProt:Q571K4]
exact_synonym: "Map3k7ip3" [UniProt:Q571K4, MGI:1913974]
exact_synonym: "Mitogen-activated protein kinase kinase kinase 7-interacting protein 3" [UniProt:Q571K4]
exact_synonym: "TAB-3" [UniProt:Q571K4]
exact_synonym: "Tab3" [UniProt:Q571K4, MGI:1913974]
exact_synonym: "TAK1-binding protein 3" [UniProt:Q571K4]
exact_synonym: "TGF-beta activated kinase 1/MAP3K7 binding protein 3" [MGI:1913974]
exact_synonym: "TGF-beta-activated kinase 1 and MAP3K7-binding protein 3" [UniProt:Q571K4]
exact_synonym: "TGF-beta-activated kinase 1-binding protein 3" [UniProt:Q571K4]
xref_analog: UniProt:Q571K4
relationship: sequence_of IMR:0002666 ! TAB3

[Term]
id: IMR:0002671
name: adenosine A2A receptor
xref_analog: GO:0001611
is_a: IMR:0002675 ! adenosine receptor

[Term]
id: IMR:0002672
name: AA2AR_HUMAN
exact_synonym: "ADENOSINE A2 RECEPTOR" [MIM:102776]
exact_synonym: "adenosine A2a receptor" [HGNC:263, EntrezGene:135]
exact_synonym: "Adenosine receptor A2a" [UniProt:P29274]
exact_synonym: "ADORA2" [UniProt:P29274, EntrezGene:135, MIM:102776]
exact_synonym: "ADORA2A" [UniProt:P29274, HGNC:263, EntrezGene:135, MIM:102776]
exact_synonym: "hA2aR" [EntrezGene:135]
exact_synonym: "RDC8" [HGNC:263, EntrezGene:135, MIM:102776]
xref_analog: UniProt:P29274
relationship: sequence_of IMR:0002671 ! adenosine A2A receptor

[Term]
id: IMR:0002673
name: AA2AR_MOUSE
exact_synonym: "A2a, Rs" [MGI:99402]
exact_synonym: "A2AAR" [MGI:99402]
exact_synonym: "A2aR" [MGI:99402]
exact_synonym: "AA2AR" [MGI:99402]
exact_synonym: "adenosine A2a receptor" [MGI:99402]
exact_synonym: "Adenosine receptor A2a" [UniProt:Q60613]
exact_synonym: "Adora2a" [MGI:99402, UniProt:Q60613]
xref_analog: UniProt:Q60613
relationship: sequence_of IMR:0002671 ! adenosine A2A receptor

[Term]
id: IMR:0002674
name: AA2AR_RAT
exact_synonym: "adenosine A2a receptor" [RGD:2049]
exact_synonym: "Adenosine receptor A2a" [UniProt:P30543]
exact_synonym: "Adora2a" [UniProt:P30543, RGD:2049]
xref_analog: UniProt:P30543
relationship: sequence_of IMR:0002671 ! adenosine A2A receptor

[Term]
id: IMR:0002675
name: adenosine receptor
def: "Four adenosine receptors have been cloned and characterized from several mammalian species. The receptors are named adenosine A1, A2A, A2B, and A3. The A2A and A2B receptors preferably interact with members of the Gs family of G proteins and the A1 and A3 receptors with Gi/o proteins." [PubMed:11734617, PubMed:12834807]
xref_analog: GO:0001609
is_a: IMR:0000137 ! G-Protein Coupled Receptor

[Term]
id: IMR:0002676
name: adenosine A1 receptor
xref_analog: GO:0001610
is_a: IMR:0002675 ! adenosine receptor

[Term]
id: IMR:0002677
name: adenosine A2B receptor
xref_analog: GO:0001612
is_a: IMR:0002675 ! adenosine receptor

[Term]
id: IMR:0002678
name: adenosine A3 receptor
xref_analog: GO:0001613
is_a: IMR:0002675 ! adenosine receptor

[Term]
id: IMR:0002679
name: AA1R_HUMAN
exact_synonym: "adenosine A1 receptor" [EntrezGene:134, HGNC:262, MIM:102775]
exact_synonym: "Adenosine receptor A1" [UniProt:P30542]
exact_synonym: "ADORA1" [EntrezGene:134, UniProt:P30542, HGNC:262, MIM:102775]
exact_synonym: "RDC7" [EntrezGene:134, HGNC:262, MIM:102775]
xref_analog: UniProt:P30542
relationship: sequence_of IMR:0002676 ! adenosine A1 receptor

[Term]
id: IMR:0002680
name: AA1R_MOUSE
exact_synonym: "A1-AR" [MGI:99401]
exact_synonym: "A1AR" [MGI:99401]
exact_synonym: "A1R" [MGI:99401]
exact_synonym: "AA1R" [MGI:99401]
exact_synonym: "adenosine A1 receptor" [MGI:99401]
exact_synonym: "Adenosine receptor A1" [UniProt:Q60612]
exact_synonym: "Adora1" [MGI:99401, UniProt:Q60612]
exact_synonym: "Ri" [MGI:99401]
xref_analog: UniProt:Q60612
relationship: sequence_of IMR:0002676 ! adenosine A1 receptor

[Term]
id: IMR:0002681
name: AA1R_RAT
exact_synonym: "adenosine A1 receptor" [RGD:2048]
exact_synonym: "Adenosine receptor A1" [UniProt:P25099]
exact_synonym: "Adora1" [UniProt:P25099, RGD:2048]
xref_analog: UniProt:P25099
relationship: sequence_of IMR:0002676 ! adenosine A1 receptor

[Term]
id: IMR:0002682
name: AA2BR_HUMAN
exact_synonym: "adenosine A2b receptor" [EntrezGene:136, HGNC:264, MIM:600446]
exact_synonym: "Adenosine receptor A2b" [UniProt:P29275]
exact_synonym: "ADORA2" [EntrezGene:136]
exact_synonym: "ADORA2B" [UniProt:P29275, EntrezGene:136, HGNC:264, MIM:600446]
xref_analog: UniProt:P29275
relationship: sequence_of IMR:0002677 ! adenosine A2B receptor

[Term]
id: IMR:0002683
name: AA2BR_MOUSE
exact_synonym: "A2b" [MGI:99403]
exact_synonym: "A2b, Rs" [MGI:99403]
exact_synonym: "A2BAR" [MGI:99403]
exact_synonym: "A2BR" [MGI:99403]
exact_synonym: "AA2BR" [MGI:99403]
exact_synonym: "adenosine A2b receptor" [MGI:99403]
exact_synonym: "Adenosine receptor A2b" [UniProt:Q60614]
exact_synonym: "Adora2b" [MGI:99403, UniProt:Q60614]
xref_analog: UniProt:Q60614
relationship: sequence_of IMR:0002677 ! adenosine A2B receptor

[Term]
id: IMR:0002684
name: AA2BR_RAT
exact_synonym: "adenosine A2B receptor" [RGD:2050]
exact_synonym: "Adenosine receptor A2b" [UniProt:P29276]
exact_synonym: "Adora2b" [RGD:2050, UniProt:P29276]
xref_analog: UniProt:P29276
relationship: sequence_of IMR:0002677 ! adenosine A2B receptor

[Term]
id: IMR:0002685
name: AA3R_HUMAN
exact_synonym: "A3 ADENOSINE RECEPTOR" [MIM:600445]
exact_synonym: "A3AR" [EntrezGene:140, MIM:600445]
exact_synonym: "AD026" [EntrezGene:140, HGNC:268]
exact_synonym: "adenosine A3 receptor" [EntrezGene:140, HGNC:268, MIM:600445]
exact_synonym: "Adenosine receptor A3" [UniProt:P33765]
exact_synonym: "ADORA3" [EntrezGene:140, HGNC:268, UniProt:P33765, MIM:600445]
exact_synonym: "bA552M11.5" [EntrezGene:140]
xref_analog: UniProt:P33765
relationship: sequence_of IMR:0002678 ! adenosine A3 receptor

[Term]
id: IMR:0002686
name: AA3R_MOUSE
exact_synonym: "A3AR" [UniProt:Q61618, MGI:104847]
exact_synonym: "A3R" [MGI:104847]
exact_synonym: "AA3R" [MGI:104847]
exact_synonym: "adenosine A3 receptor" [MGI:104847]
exact_synonym: "Adenosine receptor A3" [UniProt:Q61618]
exact_synonym: "Adora3" [UniProt:Q61618, MGI:104847]
exact_synonym: "ARA3" [MGI:104847]
exact_synonym: "Gpcr 2" [MGI:104847]
exact_synonym: "Gpcr2" [UniProt:Q61618]
xref_analog: UniProt:Q61618
relationship: sequence_of IMR:0002678 ! adenosine A3 receptor

[Term]
id: IMR:0002687
name: AA3R_RAT
exact_synonym: "adenosine A3 receptor" [RGD:2051]
exact_synonym: "Adenosine receptor A3" [UniProt:P28647]
exact_synonym: "Adora3" [RGD:2051, UniProt:P28647]
exact_synonym: "TGPCR1" [UniProt:P28647]
xref_analog: UniProt:P28647
relationship: sequence_of IMR:0002678 ! adenosine A3 receptor

[Term]
id: IMR:0002688
name: IGFBP
def: "IGFBPs are a family of secreted proteins that bind IGF with high affinities that are equal to or greater than those of the IGF-IR. Six distinct IGFBPs, designated as IGFBP-1 to -6, have been isolated and characterized from human and a variety of vertebrate species." [PubMed:12466191, PubMed:15862547, PubMed:15935690]
exact_synonym: "IGF-binding protein" []
exact_synonym: "insulin-like growth factor-binding protein" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0002689
name: IGFBP-1
is_a: IMR:0002688 ! IGFBP

[Term]
id: IMR:0002690
name: IGFBP-2
is_a: IMR:0002688 ! IGFBP

[Term]
id: IMR:0002691
name: IGFBP-3
is_a: IMR:0002688 ! IGFBP

[Term]
id: IMR:0002692
name: IGFBP-4
is_a: IMR:0002688 ! IGFBP

[Term]
id: IMR:0002693
name: IGFBP-5
is_a: IMR:0002688 ! IGFBP

[Term]
id: IMR:0002694
name: IGFBP-6
is_a: IMR:0002688 ! IGFBP

[Term]
id: IMR:0002695
name: IBP1_HUMAN
exact_synonym: "AFBP" [EntrezGene:3484, HGNC:5469]
exact_synonym: "hIGFBP-1" [EntrezGene:3484, HGNC:5469]
exact_synonym: "IBP-1" [UniProt:P08833]
exact_synonym: "IBP1" [EntrezGene:3484, UniProt:P08833, MIM:146730]
exact_synonym: "IGF-binding protein 1" [UniProt:P08833]
exact_synonym: "IGF-BP25" [EntrezGene:3484, MIM:146730, HGNC:5469]
exact_synonym: "IGFBP-1" [UniProt:P08833]
exact_synonym: "IGFBP1" [EntrezGene:3484, UniProt:P08833, MIM:146730, HGNC:5469]
exact_synonym: "insulin-like growth factor binding protein 1" [EntrezGene:3484, HGNC:5469]
exact_synonym: "Insulin-like growth factor-binding protein 1" [UniProt:P08833, MIM:146730]
exact_synonym: "Placental protein 12" [UniProt:P08833, MIM:146730]
exact_synonym: "PP12" [EntrezGene:3484, UniProt:P08833, HGNC:5469]
xref_analog: UniProt:P08833
relationship: sequence_of IMR:0002689 ! IGFBP-1

[Term]
id: IMR:0002696
name: IBP1_MOUSE
exact_synonym: "IBP-1" [UniProt:P47876]
exact_synonym: "IGF-binding protein 1" [UniProt:P47876]
exact_synonym: "IGFBP-1" [UniProt:P47876, MGI:96436]
exact_synonym: "Igfbp-1" [UniProt:P47876]
exact_synonym: "Igfbp1" [UniProt:P47876, MGI:96436]
exact_synonym: "insulin-like growth factor binding protein 1" [MGI:96436]
exact_synonym: "Insulin-like growth factor-binding protein 1" [UniProt:P47876]
xref_analog: UniProt:P47876
relationship: sequence_of IMR:0002689 ! IGFBP-1

[Term]
id: IMR:0002697
name: IBP1_RAT
exact_synonym: "IBP-1" [UniProt:P21743]
exact_synonym: "IGF-binding protein 1" [UniProt:P21743]
exact_synonym: "IGFBP-1" [UniProt:P21743]
exact_synonym: "Igfbp-1" [UniProt:P21743]
exact_synonym: "Igfbp1" [RGD:2872, UniProt:P21743]
exact_synonym: "insulin-like growth factor binding protein 1" [RGD:2872]
exact_synonym: "Insulin-like growth factor-binding protein 1" [UniProt:P21743]
xref_analog: UniProt:P21743
relationship: sequence_of IMR:0002689 ! IGFBP-1

[Term]
id: IMR:0002698
name: IBP2_HUMAN
exact_synonym: "BP2" [UniProt:P18065]
exact_synonym: "IBP-2" [UniProt:P18065]
exact_synonym: "IBP2" [EntrezGene:3485, UniProt:P18065, MIM:146731]
exact_synonym: "IGF-binding protein 2" [UniProt:P18065]
exact_synonym: "IGF-BP53" [EntrezGene:3485, MIM:146731]
exact_synonym: "IGFBP-2" [UniProt:P18065]
exact_synonym: "IGFBP2" [EntrezGene:3485, UniProt:P18065, HGNC:5471, MIM:146731]
exact_synonym: "insulin-like growth factor binding protein 2, 36kDa" [EntrezGene:3485, HGNC:5471]
exact_synonym: "Insulin-like growth factor-binding protein 2" [UniProt:P18065, MIM:146731]
xref_analog: UniProt:P18065
relationship: sequence_of IMR:0002690 ! IGFBP-2

[Term]
id: IMR:0002699
name: IBP2_MOUSE
exact_synonym: "IBP-2" [UniProt:P47877]
exact_synonym: "IGF-binding protein 2" [UniProt:P47877]
exact_synonym: "IGFBP-2" [MGI:96437, UniProt:P47877]
exact_synonym: "Igfbp-2" [MGI:96437, UniProt:P47877]
exact_synonym: "Igfbp2" [MGI:96437, UniProt:P47877]
exact_synonym: "insulin-like growth factor binding protein 2" [MGI:96437]
exact_synonym: "Insulin-like growth factor-binding protein 2" [UniProt:P47877]
exact_synonym: "mIGFBP-2" [UniProt:P47877]
xref_analog: UniProt:P47877
relationship: sequence_of IMR:0002690 ! IGFBP-2

[Term]
id: IMR:0002700
name: IBP2_RAT
exact_synonym: "BRL-BP" [UniProt:P12843]
exact_synonym: "IBP-2" [UniProt:P12843]
exact_synonym: "IGF-binding protein 2" [UniProt:P12843]
exact_synonym: "IGFBP-2" [UniProt:P12843]
exact_synonym: "Igfbp-2" [UniProt:P12843]
exact_synonym: "Igfbp2" [RGD:2873, UniProt:P12843]
exact_synonym: "insulin-like growth factor binding protein 2" [RGD:2873]
exact_synonym: "Insulin-like growth factor-binding protein 2" [UniProt:P12843]
xref_analog: UniProt:P12843
relationship: sequence_of IMR:0002690 ! IGFBP-2

[Term]
id: IMR:0002701
name: IBP3_HUMAN
exact_synonym: "BP-53" [EntrezGene:3486, HGNC:5472]
exact_synonym: "IBP-3" [UniProt:P17936]
exact_synonym: "IBP3" [UniProt:P17936, EntrezGene:3486, MIM:146732, HGNC:5472]
exact_synonym: "IGF-binding protein 3" [UniProt:P17936]
exact_synonym: "IGFBP-3" [UniProt:P17936]
exact_synonym: "IGFBP3" [UniProt:P17936, EntrezGene:3486, MIM:146732, HGNC:5472]
exact_synonym: "insulin-like growth factor binding protein 3" [EntrezGene:3486, HGNC:5472]
exact_synonym: "Insulin-like growth factor-binding protein 3" [UniProt:P17936, MIM:146732]
xref_analog: UniProt:P17936
relationship: sequence_of IMR:0002691 ! IGFBP-3

[Term]
id: IMR:0002702
name: IBP3_MOUSE
exact_synonym: "IBP-3" [UniProt:P47878]
exact_synonym: "IGF-binding protein 3" [UniProt:P47878]
exact_synonym: "IGFBP-3" [MGI:96438, UniProt:P47878]
exact_synonym: "Igfbp-3" [UniProt:P47878]
exact_synonym: "Igfbp3" [MGI:96438, UniProt:P47878]
exact_synonym: "insulin-like growth factor binding protein 3" [MGI:96438]
exact_synonym: "Insulin-like growth factor-binding protein 3" [UniProt:P47878]
xref_analog: UniProt:P47878
relationship: sequence_of IMR:0002691 ! IGFBP-3

[Term]
id: IMR:0002703
name: IBP3_RAT
exact_synonym: "IBP-3" [UniProt:P15473]
exact_synonym: "IGF-binding protein 3" [UniProt:P15473]
exact_synonym: "IGFBP-3" [UniProt:P15473]
exact_synonym: "Igfbp-3" [UniProt:P15473]
exact_synonym: "Igfbp3" [UniProt:P15473, RGD:2874]
exact_synonym: "insulin-like growth factor binding protein 3" [RGD:2874]
exact_synonym: "Insulin-like growth factor-binding protein 3" [UniProt:P15473]
xref_analog: UniProt:P15473
relationship: sequence_of IMR:0002691 ! IGFBP-3

[Term]
id: IMR:0002704
name: IBP4_HUMAN
exact_synonym: "BP-4" [HGNC:5473, EntrezGene:3487]
exact_synonym: "HT29-IGFBP" [HGNC:5473, EntrezGene:3487]
exact_synonym: "IBP-4" [UniProt:P22692]
exact_synonym: "IBP4" [MIM:146733, HGNC:5473, UniProt:P22692, EntrezGene:3487]
exact_synonym: "IGF-binding protein 4" [UniProt:P22692]
exact_synonym: "IGFBP-4" [HGNC:5473, UniProt:P22692, EntrezGene:3487]
exact_synonym: "IGFBP4" [MIM:146733, HGNC:5473, UniProt:P22692, EntrezGene:3487]
exact_synonym: "insulin-like growth factor binding protein 4" [HGNC:5473, EntrezGene:3487]
exact_synonym: "Insulin-like growth factor-binding protein 4" [MIM:146733, UniProt:P22692]
xref_analog: UniProt:P22692
relationship: sequence_of IMR:0002692 ! IGFBP-4

[Term]
id: IMR:0002705
name: IBP4_MOUSE
exact_synonym: "Band 3A" [MGI:96439]
exact_synonym: "Deb2" [MGI:96439]
exact_synonym: "IBP-4" [UniProt:P47879]
exact_synonym: "IGF-binding protein 4" [UniProt:P47879]
exact_synonym: "IGFBP-4" [UniProt:P47879, MGI:96439]
exact_synonym: "Igfbp-4" [UniProt:P47879]
exact_synonym: "Igfbp4" [UniProt:P47879, MGI:96439]
exact_synonym: "insulin-like growth factor binding protein 4" [MGI:96439]
exact_synonym: "Insulin-like growth factor-binding protein 4" [UniProt:P47879]
xref_analog: UniProt:P47879
relationship: sequence_of IMR:0002692 ! IGFBP-4

[Term]
id: IMR:0002706
name: IBP4_RAT
exact_synonym: "IBP-4" [UniProt:P21744]
exact_synonym: "IGF-binding protein 4" [UniProt:P21744]
exact_synonym: "IGFBP-4" [UniProt:P21744]
exact_synonym: "Igfbp-4" [UniProt:P21744]
exact_synonym: "Igfbp4" [RGD:2875, UniProt:P21744]
exact_synonym: "insulin-like growth factor binding protein 4" [RGD:2875]
exact_synonym: "Insulin-like growth factor-binding protein 4" [UniProt:P21744]
xref_analog: UniProt:P21744
relationship: sequence_of IMR:0002692 ! IGFBP-4

[Term]
id: IMR:0002707
name: IBP5_HUMAN
exact_synonym: "IBP-5" [UniProt:P24593]
exact_synonym: "IBP5" [MIM:146734, EntrezGene:3488, UniProt:P24593]
exact_synonym: "IGF-binding protein 5" [UniProt:P24593]
exact_synonym: "IGFBP-5" [UniProt:P24593]
exact_synonym: "IGFBP5" [HGNC:5474, MIM:146734, EntrezGene:3488, UniProt:P24593]
exact_synonym: "insulin-like growth factor binding protein 5" [HGNC:5474, EntrezGene:3488]
exact_synonym: "Insulin-like growth factor-binding protein 5" [MIM:146734, UniProt:P24593]
xref_analog: UniProt:P24593
relationship: sequence_of IMR:0002693 ! IGFBP-5

[Term]
id: IMR:0002708
name: IBP5_MOUSE
exact_synonym: "IBP-5" [UniProt:Q07079]
exact_synonym: "IGF-binding protein 5" [UniProt:Q07079]
exact_synonym: "IGFBP-5" [MGI:96440, UniProt:Q07079]
exact_synonym: "Igfbp-5" [UniProt:Q07079]
exact_synonym: "IGFBP-5P" [MGI:96440]
exact_synonym: "Igfbp5" [MGI:96440, UniProt:Q07079]
exact_synonym: "insulin-like growth factor binding protein 5" [MGI:96440]
exact_synonym: "Insulin-like growth factor-binding protein 5" [UniProt:Q07079]
xref_analog: UniProt:Q07079
relationship: sequence_of IMR:0002693 ! IGFBP-5

[Term]
id: IMR:0002709
name: IBP5_RAT
exact_synonym: "IBP-5" [UniProt:P24594]
exact_synonym: "IGF-binding protein 5" [UniProt:P24594]
exact_synonym: "IGFBP-5" [UniProt:P24594]
exact_synonym: "Igfbp-5" [UniProt:P24594]
exact_synonym: "Igfbp5" [UniProt:P24594, RGD:2876]
exact_synonym: "insulin-like growth factor binding protein 5" [RGD:2876]
exact_synonym: "Insulin-like growth factor-binding protein 5" [UniProt:P24594]
xref_analog: UniProt:P24594
relationship: sequence_of IMR:0002693 ! IGFBP-5

[Term]
id: IMR:0002710
name: IBP6_HUMAN
exact_synonym: "IBP-6" [UniProt:P24592]
exact_synonym: "IBP6" [EntrezGene:3489, MIM:146735, UniProt:P24592]
exact_synonym: "IGF-binding protein 6" [UniProt:P24592]
exact_synonym: "IGFBP-6" [UniProt:P24592]
exact_synonym: "IGFBP6" [HGNC:5475, EntrezGene:3489, MIM:146735, UniProt:P24592]
exact_synonym: "insulin-like growth factor binding protein 6" [HGNC:5475, EntrezGene:3489]
exact_synonym: "Insulin-like growth factor-binding protein 6" [MIM:146735, UniProt:P24592]
xref_analog: UniProt:P24592
relationship: sequence_of IMR:0002694 ! IGFBP-6

[Term]
id: IMR:0002711
name: IBP6_MOUSE
exact_synonym: "IBP-6" [UniProt:P47880]
exact_synonym: "IGF-binding protein 6" [UniProt:P47880]
exact_synonym: "IGFBP-6" [UniProt:P47880, MGI:96441]
exact_synonym: "Igfbp-6" [UniProt:P47880]
exact_synonym: "Igfbp6" [UniProt:P47880, MGI:96441]
exact_synonym: "insulin-like growth factor binding protein 6" [MGI:96441]
exact_synonym: "Insulin-like growth factor-binding protein 6" [UniProt:P47880]
xref_analog: UniProt:P47880
relationship: sequence_of IMR:0002694 ! IGFBP-6

[Term]
id: IMR:0002712
name: IBP6_RAT
exact_synonym: "IBP-6" [UniProt:P35572]
exact_synonym: "IGF-binding protein 6" [UniProt:P35572]
exact_synonym: "IGFBP-6" [UniProt:P35572]
exact_synonym: "Igfbp-6" [UniProt:P35572]
exact_synonym: "Igfbp6" [UniProt:P35572, RGD:2877]
exact_synonym: "insulin-like growth factor binding protein 6" [RGD:2877]
exact_synonym: "Insulin-like growth factor-binding protein 6" [UniProt:P35572]
xref_analog: UniProt:P35572
relationship: sequence_of IMR:0002694 ! IGFBP-6

[Term]
id: IMR:0002713
name: prostate-specific antigen
exact_synonym: "prostate specific antigen" []
exact_synonym: "PSA" []
is_a: IMR:0000304 ! protease

[Term]
id: IMR:0002714
name: KLK3_HUMAN
exact_synonym: "ANTIGEN, PROSTATE-SPECIFIC" [MIM:176820]
exact_synonym: "APS" [UniProt:P07288, MIM:176820, EntrezGene:354]
exact_synonym: "EC 3.4.21.77" [UniProt:P07288]
exact_synonym: "Gamma-seminoprotein" [UniProt:P07288]
exact_synonym: "hK3" [EntrezGene:354]
exact_synonym: "KALLIKREIN 3" [MIM:176820]
exact_synonym: "Kallikrein-3" [UniProt:P07288]
exact_synonym: "kallikrein-related peptidase 3" [HGNC:6364, MIM:176820, EntrezGene:354]
exact_synonym: "KLK2A1" [EntrezGene:354]
exact_synonym: "KLK3" [HGNC:6364, UniProt:P07288, MIM:176820, EntrezGene:354]
exact_synonym: "P-30 antigen" [UniProt:P07288]
exact_synonym: "Prostate-specific antigen" [UniProt:P07288, MIM:176820]
exact_synonym: "PSA" [HGNC:6364, UniProt:P07288, MIM:176820, EntrezGene:354]
exact_synonym: "Semenogelase" [UniProt:P07288]
exact_synonym: "Seminin" [UniProt:P07288]
xref_analog: UniProt:P07288
relationship: sequence_of IMR:0002713 ! prostate-specific antigen

[Term]
id: IMR:0002715
name: KLK3_RAT
exact_synonym: "EC 3.4.21.35" [UniProt:P15950]
exact_synonym: "Glandular kallikrein-3, submandibular" [UniProt:P15950]
exact_synonym: "Klk-3" [UniProt:P15950]
exact_synonym: "Klk3" [UniProt:P15950]
exact_synonym: "rGK-3" [UniProt:P15950]
exact_synonym: "RSGK-50" [UniProt:P15950]
exact_synonym: "S1 kallikrein" [UniProt:P15950]
exact_synonym: "Tissue kallikrein" [UniProt:P15950]
xref_analog: UniProt:P15950
relationship: sequence_of IMR:0002713 ! prostate-specific antigen

[Term]
id: IMR:0002716
name: IL-23
exact_synonym: "interleukin-23" []
xref_analog: GO:0045519
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0002717
name: IL-23 receptor
exact_synonym: "interleukin-23 receptor" []
xref_analog: GO:0042020
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0002718
name: IL-27
exact_synonym: "interleukin-27" []
xref_analog: GO:0045523
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0002719
name: IL-23R
relationship: part_of IMR:0002717 ! IL-23 receptor

[Term]
id: IMR:0002720
name: IL-23A
exact_synonym: "Interleukin-23 subunit alpha" []
exact_synonym: "Interleukin-23 subunit p19" []
relationship: part_of IMR:0002716 ! IL-23

[Term]
id: IMR:0002721
name: TOR
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0002722
name: MTOR_HUMAN
exact_synonym: "EC 2.7.11.1" [UniProt:P42345]
exact_synonym: "FK506-binding protein 12-rapamycin complex-associated protein 1" [UniProt:P42345, MIM:601231]
exact_synonym: "FKBP12-rapamycin complex-associated protein" [UniProt:P42345]
exact_synonym: "FKBP12-RAPAMYCIN COMPLEX-ASSOCIATED PROTEIN 1" [MIM:601231]
exact_synonym: "FLJ44809" [EntrezGene:2475, HGNC:3942]
exact_synonym: "FRAP" [EntrezGene:2475, UniProt:P42345, MIM:601231]
exact_synonym: "FRAP1" [EntrezGene:2475, UniProt:P42345, MIM:601231]
exact_synonym: "FRAP2" [EntrezGene:2475, UniProt:P42345, MIM:601231]
exact_synonym: "Mammalian target of rapamycin" [UniProt:P42345, MIM:601231]
exact_synonym: "Mechanistic target of rapamycin" [UniProt:P42345]
exact_synonym: "mechanistic target of rapamycin (serine/threonine kinase)" [EntrezGene:2475, HGNC:3942]
exact_synonym: "mTOR" [UniProt:P42345, MIM:601231]
exact_synonym: "MTOR" [EntrezGene:2475, UniProt:P42345, HGNC:3942]
exact_synonym: "RAFT1" [EntrezGene:2475, MIM:601231, HGNC:3942]
exact_synonym: "Rapamycin target protein 1" [UniProt:P42345]
exact_synonym: "RAPT1" [EntrezGene:2475, UniProt:P42345, HGNC:3942]
exact_synonym: "Serine/threonine-protein kinase mTOR" [UniProt:P42345]
xref_analog: UniProt:P42345
relationship: sequence_of IMR:0002721 ! TOR

[Term]
id: IMR:0002723
name: MTOR_MOUSE
exact_synonym: "EC 2.7.11.1" [UniProt:Q9JLN9]
exact_synonym: "FK506-binding protein 12-rapamycin complex-associated protein 1" [UniProt:Q9JLN9]
exact_synonym: "FKBP-rapamycin-associated protein FRAP" [MGI:1928394]
exact_synonym: "FKBP12-rapamycin complex-associated protein" [UniProt:Q9JLN9]
exact_synonym: "flat" [MGI:1928394]
exact_synonym: "Frap" [UniProt:Q9JLN9]
exact_synonym: "Frap1" [UniProt:Q9JLN9, MGI:1928394]
exact_synonym: "Mammalian target of rapamycin" [UniProt:Q9JLN9]
exact_synonym: "Mechanistic target of rapamycin" [UniProt:Q9JLN9]
exact_synonym: "mechanistic target of rapamycin (serine/threonine kinase)" [MGI:1928394]
exact_synonym: "mTOR" [UniProt:Q9JLN9]
exact_synonym: "Mtor" [UniProt:Q9JLN9, MGI:1928394]
exact_synonym: "RAFT1" [MGI:1928394]
exact_synonym: "Rapamycin target protein 1" [UniProt:Q9JLN9]
exact_synonym: "RAPT1" [UniProt:Q9JLN9, MGI:1928394]
exact_synonym: "Serine/threonine-protein kinase mTOR" [UniProt:Q9JLN9]
xref_analog: UniProt:Q9JLN9
relationship: sequence_of IMR:0002721 ! TOR

[Term]
id: IMR:0002724
name: MTOR_RAT
exact_synonym: "EC 2.7.11.1" [UniProt:P42346]
exact_synonym: "FK506-binding protein 12-rapamycin complex-associated protein 1" [UniProt:P42346]
exact_synonym: "FKBP12-rapamycin complex-associated protein" [UniProt:P42346]
exact_synonym: "Frap1" [UniProt:P42346]
exact_synonym: "Mammalian target of rapamycin" [UniProt:P42346]
exact_synonym: "Mechanistic target of rapamycin" [UniProt:P42346]
exact_synonym: "mechanistic target of rapamycin (serine/threonine kinase)" [RGD:68371]
exact_synonym: "mTOR" [UniProt:P42346]
exact_synonym: "Mtor" [UniProt:P42346, RGD:68371]
exact_synonym: "Raft1" [UniProt:P42346]
exact_synonym: "Rapamycin target protein 1" [UniProt:P42346]
exact_synonym: "RAPT1" [UniProt:P42346]
exact_synonym: "Serine/threonine-protein kinase mTOR" [UniProt:P42346]
xref_analog: UniProt:P42346
relationship: sequence_of IMR:0002721 ! TOR

[Term]
id: IMR:0002725
name: TOR_DROME
exact_synonym: "CG5092" [FlyBase:FBgn0021796]
exact_synonym: "CT16317" [FlyBase:FBgn0021796]
exact_synonym: "CT24745" [FlyBase:FBgn0021796]
exact_synonym: "CT24817" [FlyBase:FBgn0021796]
exact_synonym: "dTOR" [FlyBase:FBgn0021796]
exact_synonym: "dtor" [FlyBase:FBgn0021796]
exact_synonym: "dTor" [FlyBase:FBgn0021796]
exact_synonym: "EC 2.7.1.-" [UniProt:Q9VK45]
exact_synonym: "FRAP/TOR" [FlyBase:FBgn0021796]
exact_synonym: "l(2)k17004" [FlyBase:FBgn0021796]
exact_synonym: "mTOR" [FlyBase:FBgn0021796]
exact_synonym: "Target of rapamycin" [FlyBase:FBgn0021796, UniProt:Q9VK45]
exact_synonym: "target-of-rapamycin" [FlyBase:FBgn0021796]
exact_synonym: "Tor" [FlyBase:FBgn0021796, UniProt:Q9VK45]
exact_synonym: "TOR" [FlyBase:FBgn0021796]
xref_analog: UniProt:Q9VK45
relationship: sequence_of IMR:0002721 ! TOR

[Term]
id: IMR:0002726
name: TOR1_YEAST
exact_synonym: "Dominant rapamycin resistance protein 1" [UniProt:P35169]
exact_synonym: "DRR1" [UniProt:P35169]
exact_synonym: "EC 2.7.11.1" [UniProt:P35169]
exact_synonym: "Phosphatidylinositol kinase homolog TOR1" [UniProt:P35169]
exact_synonym: "Serine/threonine-protein kinase TOR1" [UniProt:P35169]
exact_synonym: "Target of rapamycin kinase 1" [UniProt:P35169]
exact_synonym: "TOR1" [UniProt:P35169]
xref_analog: UniProt:P35169
relationship: sequence_of IMR:0002721 ! TOR

[Term]
id: IMR:0002727
name: TOR2_YEAST
exact_synonym: "Dominant rapamycin resistance protein 2" [UniProt:P32600]
exact_synonym: "DRR2" [UniProt:P32600]
exact_synonym: "EC 2.7.1.67" [UniProt:P32600]
exact_synonym: "EC 2.7.11.1" [UniProt:P32600]
exact_synonym: "Phosphatidylinositol 4-kinase TOR2" [UniProt:P32600]
exact_synonym: "PI4-kinase TOR2" [UniProt:P32600]
exact_synonym: "PI4K TOR2" [UniProt:P32600]
exact_synonym: "PtdIns-4-kinase TOR2" [UniProt:P32600]
exact_synonym: "Serine/threonine-protein kinase TOR2" [UniProt:P32600]
exact_synonym: "Target of rapamycin kinase 2" [UniProt:P32600]
exact_synonym: "Temperature-sensitive CSG2 suppressor protein 14" [UniProt:P32600]
exact_synonym: "TOR2" [UniProt:P32600]
exact_synonym: "TSC14" [UniProt:P32600]
xref_analog: UniProt:P32600
relationship: sequence_of IMR:0002721 ! TOR

[Term]
id: IMR:0002728
name: TOR1_SCHPO
exact_synonym: "EC 2.7.1.137" [UniProt:O14356]
exact_synonym: "Phosphatidylinositol 3-kinase tor1" [UniProt:O14356]
exact_synonym: "PI3-kinase tor1" [UniProt:O14356]
exact_synonym: "PI3K tor1" [UniProt:O14356]
exact_synonym: "PtdIns-3-kinase tor1" [UniProt:O14356]
exact_synonym: "tor1" [UniProt:O14356]
xref_analog: UniProt:O14356
relationship: sequence_of IMR:0002721 ! TOR

[Term]
id: IMR:0002729
name: TOR2_SCHPO
exact_synonym: "EC 2.7.1.137" [UniProt:Q9Y7K2]
exact_synonym: "Phosphatidylinositol 3-kinase tor2" [UniProt:Q9Y7K2]
exact_synonym: "PI3-kinase tor2" [UniProt:Q9Y7K2]
exact_synonym: "PI3K tor2" [UniProt:Q9Y7K2]
exact_synonym: "PtdIns-3-kinase tor2" [UniProt:Q9Y7K2]
exact_synonym: "tor2" [UniProt:Q9Y7K2]
xref_analog: UniProt:Q9Y7K2
relationship: sequence_of IMR:0002721 ! TOR

[Term]
id: IMR:0002730
name: Raptor
is_a: IMR:0000333 ! adaptor protein

[Term]
id: IMR:0002731
name: RPTOR_HUMAN
exact_synonym: "KIAA1303" [HGNC:30287, MIM:607130, EntrezGene:57521, UniProt:Q8N122]
exact_synonym: "KOG1" [HGNC:30287, EntrezGene:57521]
exact_synonym: "Mip1" [HGNC:30287, EntrezGene:57521]
exact_synonym: "p150 target of rapamycin (TOR)-scaffold protein" [UniProt:Q8N122]
exact_synonym: "RAPTOR" [MIM:607130, UniProt:Q8N122]
exact_synonym: "Raptor" [UniProt:Q8N122]
exact_synonym: "raptor" [HGNC:30287]
exact_synonym: "REGULATORY ASSOCIATED PROTEIN OF MTOR" [MIM:607130]
exact_synonym: "regulatory associated protein of MTOR, complex 1" [HGNC:30287, EntrezGene:57521]
exact_synonym: "Regulatory-associated protein of mTOR" [UniProt:Q8N122]
exact_synonym: "RPTOR" [HGNC:30287, MIM:607130, EntrezGene:57521, UniProt:Q8N122]
xref_analog: UniProt:Q8N122
relationship: sequence_of IMR:0002730 ! Raptor

[Term]
id: IMR:0002732
name: RPTOR_MOUSE
exact_synonym: "p150 target of rapamycin (TOR)-scaffold protein" [UniProt:Q8K4Q0]
exact_synonym: "Rap" [MGI:1921620]
exact_synonym: "Raptor" [UniProt:Q8K4Q0]
exact_synonym: "raptor" [MGI:1921620]
exact_synonym: "regulatory associated protein of MTOR, complex 1" [MGI:1921620]
exact_synonym: "Regulatory-associated protein of mTOR" [UniProt:Q8K4Q0]
exact_synonym: "Rptor" [MGI:1921620, UniProt:Q8K4Q0]
xref_analog: UniProt:Q8K4Q0
relationship: sequence_of IMR:0002730 ! Raptor

[Term]
id: IMR:0002733
name: Q9W437_DROME
exact_synonym: "CG4320" [FlyBase:FBgn0029840]
exact_synonym: "dRaptor" [FlyBase:FBgn0029840]
exact_synonym: "Raptor" [UniProt:Q9W437]
exact_synonym: "raptor" [FlyBase:FBgn0029840, UniProt:Q9W437]
xref_analog: UniProt:Q9W437
relationship: sequence_of IMR:0002730 ! Raptor

[Term]
id: IMR:0002734
name: KOG1_YEAST
exact_synonym: "KOG1" [UniProt:P38873]
exact_synonym: "Kontroller of growth protein 1" [UniProt:P38873]
exact_synonym: "LAS24" [UniProt:P38873]
exact_synonym: "Local anesthetic-sensitive protein 24" [UniProt:P38873]
exact_synonym: "Target of rapamycin complex 1 subunit KOG1" [UniProt:P38873]
exact_synonym: "TORC1 subunit KOG1" [UniProt:P38873]
xref_analog: UniProt:P38873
relationship: sequence_of IMR:0002730 ! Raptor

[Term]
id: IMR:0002735
name: MIP1_SCHPO
exact_synonym: "mip1" [UniProt:P87141]
exact_synonym: "WD repeat-containing protein mip1" [UniProt:P87141]
xref_analog: UniProt:P87141
relationship: sequence_of IMR:0002730 ! Raptor

[Term]
id: IMR:0002736
name: LST8
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0002737
name: LST8_YEAST
exact_synonym: "Lethal with SEC13 protein 8" [UniProt:P41318]
exact_synonym: "LST8" [UniProt:P41318]
exact_synonym: "Target of rapamycin complex subunit LST8" [UniProt:P41318]
exact_synonym: "TORC subunit LST8" [UniProt:P41318]
xref_analog: UniProt:P41318
relationship: sequence_of IMR:0002736 ! LST8

[Term]
id: IMR:0002738
name: LST8_HUMAN
exact_synonym: "G protein beta subunit-like" [UniProt:Q9BVC4]
exact_synonym: "G PROTEIN BETA SUBUNIT-LIKE PROTEIN" [MIM:612190]
exact_synonym: "G-BETA-LIKE PROTEIN" [MIM:612190]
exact_synonym: "Gable" [UniProt:Q9BVC4]
exact_synonym: "GbetaL" [HGNC:24825, EntrezGene:64223]
exact_synonym: "GBL" [UniProt:Q9BVC4, HGNC:24825, MIM:612190, EntrezGene:64223]
exact_synonym: "LST8" [UniProt:Q9BVC4, MIM:612190, EntrezGene:64223]
exact_synonym: "Lst8" [HGNC:24825]
exact_synonym: "LST8, S. CEREVISIAE, HOMOLOG OF" [MIM:612190]
exact_synonym: "Mammalian lethal with SEC13 protein 8" [UniProt:Q9BVC4]
exact_synonym: "MGC111011" [EntrezGene:64223]
exact_synonym: "mLST8" [UniProt:Q9BVC4]
exact_synonym: "MLST8" [UniProt:Q9BVC4, HGNC:24825, EntrezGene:64223]
exact_synonym: "MTOR associated protein, LST8 homolog (S. cerevisiae)" [HGNC:24825, EntrezGene:64223]
exact_synonym: "Pop3" [HGNC:24825, MIM:612190]
exact_synonym: "POP3" [EntrezGene:64223]
exact_synonym: "POP3, S. POMBE, HOMOLOG OF" [MIM:612190]
exact_synonym: "Protein GbetaL" [UniProt:Q9BVC4]
exact_synonym: "Target of rapamycin complex subunit LST8" [UniProt:Q9BVC4]
exact_synonym: "TORC subunit LST8" [UniProt:Q9BVC4]
exact_synonym: "WAT1" [MIM:612190, EntrezGene:64223]
exact_synonym: "WAT1, S. POMBE, HOMOLOG OF" [MIM:612190]
xref_analog: UniProt:Q9BVC4
relationship: sequence_of IMR:0002736 ! LST8

[Term]
id: IMR:0002739
name: LST8_MOUSE
exact_synonym: "G protein beta subunit-like" [UniProt:Q9DCJ1]
exact_synonym: "Gbl" [MGI:1929514, UniProt:Q9DCJ1]
exact_synonym: "Lst8" [UniProt:Q9DCJ1]
exact_synonym: "Mammalian lethal with SEC13 protein 8" [UniProt:Q9DCJ1]
exact_synonym: "mLST8" [MGI:1929514, UniProt:Q9DCJ1]
exact_synonym: "Mlst8" [MGI:1929514, UniProt:Q9DCJ1]
exact_synonym: "MTOR associated protein, LST8 homolog (S. cerevisiae)" [MGI:1929514]
exact_synonym: "Protein GbetaL" [UniProt:Q9DCJ1]
exact_synonym: "Target of rapamycin complex subunit LST8" [UniProt:Q9DCJ1]
exact_synonym: "TORC subunit LST8" [UniProt:Q9DCJ1]
xref_analog: UniProt:Q9DCJ1
relationship: sequence_of IMR:0002736 ! LST8

[Term]
id: IMR:0002740
name: LST8_RAT
exact_synonym: "G protein beta subunit-like" [UniProt:Q9Z2K5]
exact_synonym: "Gbl" [UniProt:Q9Z2K5]
exact_synonym: "Lst8" [UniProt:Q9Z2K5]
exact_synonym: "Mammalian lethal with SEC13 protein 8" [UniProt:Q9Z2K5]
exact_synonym: "mLST8" [UniProt:Q9Z2K5]
exact_synonym: "Mlst8" [RGD:69242, UniProt:Q9Z2K5]
exact_synonym: "MTOR associated protein, LST8 homolog (S. cerevisiae)" [RGD:69242]
exact_synonym: "Protein GbetaL" [UniProt:Q9Z2K5]
exact_synonym: "Target of rapamycin complex subunit LST8" [UniProt:Q9Z2K5]
exact_synonym: "TORC subunit LST8" [UniProt:Q9Z2K5]
xref_analog: UniProt:Q9Z2K5
relationship: sequence_of IMR:0002736 ! LST8

[Term]
id: IMR:0002741
name: LST8_DROME
exact_synonym: "Protein LST8 homolog" [UniProt:Q9W328]
xref_analog: UniProt:Q9W328
relationship: sequence_of IMR:0002736 ! LST8

[Term]
id: IMR:0002742
name: Rictor
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0002743
name: RICTR_HUMAN
exact_synonym: "AVO3" [MIM:609022, HGNC:28611]
exact_synonym: "AVO3 homolog" [UniProt:Q6R327]
exact_synonym: "AVO3, S. CEREVISIAE, HOMOLOG OF" [MIM:609022]
exact_synonym: "DKFZp686B11164" [EntrezGene:253260]
exact_synonym: "hAVO3" [UniProt:Q6R327]
exact_synonym: "KIAA1999" [UniProt:Q6R327, MIM:609022, HGNC:28611, EntrezGene:253260]
exact_synonym: "mAVO3" [EntrezGene:253260]
exact_synonym: "MGC39830" [HGNC:28611, EntrezGene:253260]
exact_synonym: "PIA" [HGNC:28611, EntrezGene:253260]
exact_synonym: "Rapamycin-insensitive companion of mTOR" [UniProt:Q6R327, MIM:609022]
exact_synonym: "RICTOR" [UniProt:Q6R327, MIM:609022, HGNC:28611, EntrezGene:253260]
exact_synonym: "RPTOR independent companion of MTOR, complex 2" [HGNC:28611, EntrezGene:253260]
xref_analog: UniProt:Q6R327
relationship: sequence_of IMR:0002742 ! Rictor

[Term]
id: IMR:0002744
name: RICTR_MOUSE
exact_synonym: "AVO3 homolog" [UniProt:Q6QI06]
exact_synonym: "Kiaa1999" [UniProt:Q6QI06]
exact_synonym: "mAVO3" [UniProt:Q6QI06]
exact_synonym: "Protein pianissimo" [UniProt:Q6QI06]
exact_synonym: "Rapamycin-insensitive companion of mTOR" [UniProt:Q6QI06]
exact_synonym: "Rictor" [MGI:1926007, UniProt:Q6QI06]
exact_synonym: "RPTOR independent companion of MTOR, complex 2" [MGI:1926007]
xref_analog: UniProt:Q6QI06
relationship: sequence_of IMR:0002742 ! Rictor

[Term]
id: IMR:0002745
name: Q9VWJ6_DROME
exact_synonym: "CG8002" [FlyBase:FBgn0031006]
exact_synonym: "dRictor" [FlyBase:FBgn0031006]
exact_synonym: "FI03615p" [UniProt:Q9VWJ6]
exact_synonym: "Rapamycin-insensitive companion of Tor" [UniProt:Q9VWJ6]
exact_synonym: "rapamycin-insensitive companion of Tor" [FlyBase:FBgn0031006]
exact_synonym: "rictor" [UniProt:Q9VWJ6, FlyBase:FBgn0031006]
exact_synonym: "rictor-RA" [UniProt:Q9VWJ6]
xref_analog: UniProt:Q9VWJ6
relationship: sequence_of IMR:0002742 ! Rictor

[Term]
id: IMR:0002746
name: TSC11_YEAST
exact_synonym: "Adheres voraciously to TOR2 protein 3" [UniProt:P40061]
exact_synonym: "AVO3" [UniProt:P40061]
exact_synonym: "Target of rapamycin complex 2 subunit TSC11" [UniProt:P40061]
exact_synonym: "Temperature-sensitive CSG2 suppressor protein 11" [UniProt:P40061]
exact_synonym: "TORC2 subunit TSC11" [UniProt:P40061]
exact_synonym: "TSC11" [UniProt:P40061]
xref_analog: UniProt:P40061
relationship: sequence_of IMR:0002742 ! Rictor

[Term]
id: IMR:0002747
name: SIN1
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0002748
name: SIN1_HUMAN
exact_synonym: "JC310" [EntrezGene:79109, MIM:610558]
exact_synonym: "MAPKAP1" [EntrezGene:79109, MIM:610558, UniProt:Q9BPZ7, HGNC:18752]
exact_synonym: "MEKK2-INTERACTING PROTEIN 1" [MIM:610558]
exact_synonym: "MGC2745" [EntrezGene:79109, HGNC:18752]
exact_synonym: "MIP1" [EntrezGene:79109, MIM:610558, UniProt:Q9BPZ7, HGNC:18752]
exact_synonym: "Mitogen-activated protein kinase 2-associated protein 1" [UniProt:Q9BPZ7]
exact_synonym: "mitogen-activated protein kinase associated protein 1" [EntrezGene:79109, HGNC:18752]
exact_synonym: "MITOGEN-ACTIVATED PROTEIN KINASE-ASSOCIATED PROTEIN 1" [MIM:610558]
exact_synonym: "mSIN1" [UniProt:Q9BPZ7]
exact_synonym: "SAPK-interacting protein 1" [MIM:610558, UniProt:Q9BPZ7]
exact_synonym: "SIN1" [EntrezGene:79109, MIM:610558, UniProt:Q9BPZ7, HGNC:18752]
exact_synonym: "SIN1b" [EntrezGene:79109]
exact_synonym: "SIN1g" [EntrezGene:79109]
exact_synonym: "Stress-activated map kinase-interacting protein 1" [UniProt:Q9BPZ7]
exact_synonym: "Target of rapamycin complex 2 subunit MAPKAP1" [UniProt:Q9BPZ7]
exact_synonym: "TORC2 subunit MAPKAP1" [UniProt:Q9BPZ7]
xref_analog: UniProt:Q9BPZ7
relationship: sequence_of IMR:0002747 ! SIN1

[Term]
id: IMR:0002749
name: SIN1_MOUSE
exact_synonym: "Mapkap1" [MGI:2444554, UniProt:Q8BKH7]
exact_synonym: "Mip1" [UniProt:Q8BKH7]
exact_synonym: "Mitogen-activated protein kinase 2-associated protein 1" [UniProt:Q8BKH7]
exact_synonym: "mitogen-activated protein kinase associated protein 1" [MGI:2444554]
exact_synonym: "SAPK-interacting protein 1" [UniProt:Q8BKH7]
exact_synonym: "Sin1" [MGI:2444554, UniProt:Q8BKH7]
exact_synonym: "Stress-activated map kinase-interacting protein 1" [UniProt:Q8BKH7]
exact_synonym: "Target of rapamycin complex 2 subunit MAPKAP1" [UniProt:Q8BKH7]
exact_synonym: "TORC2 subunit MAPKAP1" [UniProt:Q8BKH7]
xref_analog: UniProt:Q8BKH7
relationship: sequence_of IMR:0002747 ! SIN1

[Term]
id: IMR:0002750
name: SIN1_RAT
exact_synonym: "Mapkap1" [RGD:1305363, UniProt:Q6AYF1]
exact_synonym: "Mip1" [UniProt:Q6AYF1]
exact_synonym: "Mitogen-activated protein kinase 2-associated protein 1" [UniProt:Q6AYF1]
exact_synonym: "mitogen-activated protein kinase associated protein 1" [RGD:1305363]
exact_synonym: "SAPK-interacting protein 1" [UniProt:Q6AYF1]
exact_synonym: "Sin1" [UniProt:Q6AYF1]
exact_synonym: "Stress-activated map kinase-interacting protein 1" [UniProt:Q6AYF1]
exact_synonym: "Target of rapamycin complex 2 subunit MAPKAP1" [UniProt:Q6AYF1]
exact_synonym: "TORC2 subunit MAPKAP1" [UniProt:Q6AYF1]
xref_analog: UniProt:Q6AYF1
relationship: sequence_of IMR:0002747 ! SIN1

[Term]
id: IMR:0002751
name: AVO1_YEAST
exact_synonym: "Adheres voraciously to TOR2 protein 1" [UniProt:Q08236]
exact_synonym: "AVO1" [UniProt:Q08236]
exact_synonym: "Target of rapamycin complex 2 subunit AVO1" [UniProt:Q08236]
exact_synonym: "TORC2 subunit AVO1" [UniProt:Q08236]
xref_analog: UniProt:Q08236
relationship: sequence_of IMR:0002747 ! SIN1

[Term]
id: IMR:0002752
name: Rheb
is_a: IMR:0000288 ! small GTPase

[Term]
id: IMR:0002753
name: RHEB_HUMAN
exact_synonym: "GTP-binding protein Rheb" [UniProt:Q15382]
exact_synonym: "MGC111559" [EntrezGene:6009]
exact_synonym: "Ras homolog enriched in brain" [EntrezGene:6009, MIM:601293, HGNC:10011, UniProt:Q15382]
exact_synonym: "RAS HOMOLOG ENRICHED IN BRAIN 2, FORMERLY" [MIM:601293]
exact_synonym: "RHEB" [EntrezGene:6009, MIM:601293, HGNC:10011, UniProt:Q15382]
exact_synonym: "RHEB2" [EntrezGene:6009, UniProt:Q15382]
exact_synonym: "RHEB2, FORMERLY" [MIM:601293]
xref_analog: UniProt:Q15382
relationship: sequence_of IMR:0002752 ! Rheb

[Term]
id: IMR:0002754
name: RHEB_MOUSE
exact_synonym: "GTP-binding protein Rheb" [UniProt:Q921J2]
exact_synonym: "Ras homolog enriched in brain" [UniProt:Q921J2, MGI:97912]
exact_synonym: "Rheb" [UniProt:Q921J2, MGI:97912]
xref_analog: UniProt:Q921J2
relationship: sequence_of IMR:0002752 ! Rheb

[Term]
id: IMR:0002755
name: RHEB_RAT
exact_synonym: "GTP-binding protein Rheb" [UniProt:Q62639]
exact_synonym: "Ras homolog enriched in brain" [RGD:621840, UniProt:Q62639]
exact_synonym: "Rheb" [RGD:621840, UniProt:Q62639]
xref_analog: UniProt:Q62639
relationship: sequence_of IMR:0002752 ! Rheb

[Term]
id: IMR:0002756
name: RHEB_DROME
exact_synonym: "CG1081" [FlyBase:FBgn0041191]
exact_synonym: "Dm Rheb" [FlyBase:FBgn0041191]
exact_synonym: "DmRheb" [FlyBase:FBgn0041191]
exact_synonym: "DReb" [FlyBase:FBgn0041191]
exact_synonym: "dRheb" [FlyBase:FBgn0041191]
exact_synonym: "GTP-binding protein Rheb homolog" [UniProt:Q9VND8]
exact_synonym: "Rheb" [UniProt:Q9VND8, FlyBase:FBgn0041191]
exact_synonym: "rheb" [FlyBase:FBgn0041191]
xref_analog: UniProt:Q9VND8
relationship: sequence_of IMR:0002752 ! Rheb

[Term]
id: IMR:0002757
name: RHEB_YEAST
exact_synonym: "GTP-binding protein RSG1" [UniProt:P25378]
exact_synonym: "RHB1" [UniProt:P25378]
exact_synonym: "Rheb-like protein RHB1" [UniProt:P25378]
exact_synonym: "RSG1" [UniProt:P25378]
xref_analog: UniProt:P25378
relationship: sequence_of IMR:0002752 ! Rheb

[Term]
id: IMR:0002758
name: RHB1_SCHPO
exact_synonym: "GTP-binding protein rhb1" [UniProt:O94363]
exact_synonym: "GTP-binding protein Rheb homolog" [UniProt:O94363]
exact_synonym: "rhb1" [UniProt:O94363]
xref_analog: UniProt:O94363
relationship: sequence_of IMR:0002752 ! Rheb

[Term]
id: IMR:0002759
name: TSC2
is_a: IMR:0000442 ! GAP

[Term]
id: IMR:0002760
name: TSC2_HUMAN
exact_synonym: "FLJ43106" [EntrezGene:7249]
exact_synonym: "LAM" [HGNC:12363, EntrezGene:7249]
exact_synonym: "TSC2" [MIM:191092, HGNC:12363, EntrezGene:7249, UniProt:P49815]
exact_synonym: "TSC2 GENE" [MIM:191092]
exact_synonym: "TSC4" [EntrezGene:7249, UniProt:P49815]
exact_synonym: "TSC4 GENE, FORMERLY" [MIM:191092]
exact_synonym: "TSC4, FORMERLY" [MIM:191092]
exact_synonym: "Tuberin" [MIM:191092, UniProt:P49815]
exact_synonym: "tuberin" [HGNC:12363]
exact_synonym: "tuberous sclerosis 2" [HGNC:12363, EntrezGene:7249]
exact_synonym: "Tuberous sclerosis 2 protein" [UniProt:P49815]
xref_analog: UniProt:P49815
relationship: sequence_of IMR:0002759 ! TSC2

[Term]
id: IMR:0002761
name: TSC2_MOUSE
exact_synonym: "Tsc2" [MGI:102548, UniProt:Q61037]
exact_synonym: "Tuberin" [UniProt:Q61037]
exact_synonym: "tuberin" [MGI:102548]
exact_synonym: "tuberous sclerosis 2" [MGI:102548]
exact_synonym: "Tuberous sclerosis 2 protein homolog" [UniProt:Q61037]
xref_analog: UniProt:Q61037
relationship: sequence_of IMR:0002759 ! TSC2

[Term]
id: IMR:0002762
name: TSC2_RAT
exact_synonym: "Tsc2" [RGD:3908, UniProt:P49816]
exact_synonym: "Tuberin" [UniProt:P49816]
exact_synonym: "tuberous sclerosis 2" [RGD:3908]
exact_synonym: "Tuberous sclerosis 2 protein homolog" [UniProt:P49816]
xref_analog: UniProt:P49816
relationship: sequence_of IMR:0002759 ! TSC2

[Term]
id: IMR:0002763
name: Q9U9B0_DROME
exact_synonym: "C1" [FlyBase:FBgn0005198]
exact_synonym: "CG6975" [FlyBase:FBgn0005198]
exact_synonym: "dTSC2" [FlyBase:FBgn0005198]
exact_synonym: "dTsc2" [FlyBase:FBgn0005198]
exact_synonym: "gig" [UniProt:Q9U9B0, FlyBase:FBgn0005198]
exact_synonym: "gigas" [UniProt:Q9U9B0, FlyBase:FBgn0005198]
exact_synonym: "Gigas protein" [UniProt:Q9U9B0]
exact_synonym: "l(3)109" [FlyBase:FBgn0005198]
exact_synonym: "lethal(3)109" [FlyBase:FBgn0005198]
exact_synonym: "ME 109" [FlyBase:FBgn0005198]
exact_synonym: "Tsc2" [FlyBase:FBgn0005198]
exact_synonym: "TSC2" [FlyBase:FBgn0005198]
exact_synonym: "tsc2" [FlyBase:FBgn0005198]
xref_analog: UniProt:Q9U9B0
relationship: sequence_of IMR:0002759 ! TSC2

[Term]
id: IMR:0002764
name: TSC1
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0002765
name: TSC1_HUMAN
exact_synonym: "Hamartin" [MIM:605284, UniProt:Q92574]
exact_synonym: "hamartin" [HGNC:12362]
exact_synonym: "KIAA0243" [UniProt:Q92574, HGNC:12362]
exact_synonym: "LAM" [HGNC:12362]
exact_synonym: "TSC" [UniProt:Q92574]
exact_synonym: "TSC1" [MIM:605284, UniProt:Q92574, HGNC:12362]
exact_synonym: "TSC1 GENE" [MIM:605284]
exact_synonym: "tuberous sclerosis 1" [HGNC:12362]
exact_synonym: "Tuberous sclerosis 1 protein" [UniProt:Q92574]
xref_analog: UniProt:Q92574
relationship: sequence_of IMR:0002764 ! TSC1

[Term]
id: IMR:0002766
name: TSC1_MOUSE
exact_synonym: "Hamartin" [UniProt:Q9EP53]
exact_synonym: "hamartin" [MGI:1929183]
exact_synonym: "Kiaa0243" [UniProt:Q9EP53]
exact_synonym: "Tsc1" [MGI:1929183, UniProt:Q9EP53]
exact_synonym: "tuberous sclerosis 1" [MGI:1929183]
exact_synonym: "Tuberous sclerosis 1 protein homolog" [UniProt:Q9EP53]
xref_analog: UniProt:Q9EP53
relationship: sequence_of IMR:0002764 ! TSC1

[Term]
id: IMR:0002767
name: TSC1_RAT
exact_synonym: "Hamartin" [UniProt:Q9Z136]
exact_synonym: "Tsc1" [UniProt:Q9Z136, RGD:620124]
exact_synonym: "tuberous sclerosis 1" [RGD:620124]
exact_synonym: "Tuberous sclerosis 1 protein homolog" [UniProt:Q9Z136]
xref_analog: UniProt:Q9Z136
relationship: sequence_of IMR:0002764 ! TSC1

[Term]
id: IMR:0002768
name: Q9U9A9_DROME
exact_synonym: "CG6147" [FlyBase:FBgn0026317]
exact_synonym: "dTSC" [FlyBase:FBgn0026317]
exact_synonym: "dTsc1" [FlyBase:FBgn0026317]
exact_synonym: "dTSC1" [FlyBase:FBgn0026317]
exact_synonym: "hamartin" [FlyBase:FBgn0026317]
exact_synonym: "rocky" [FlyBase:FBgn0026317]
exact_synonym: "Tsc1" [UniProt:Q9U9A9, FlyBase:FBgn0026317]
exact_synonym: "TSC1" [UniProt:Q9U9A9, FlyBase:FBgn0026317]
exact_synonym: "tsc1" [FlyBase:FBgn0026317]
exact_synonym: "Tuberous sclerosis gene product-1 homolog" [UniProt:Q9U9A9]
xref_analog: UniProt:Q9U9A9
relationship: sequence_of IMR:0002764 ! TSC1

[Term]
id: IMR:0002769
name: AKT1_DROME
exact_synonym: "Akt" [UniProt:Q8INB9, FlyBase:FBgn0010379]
exact_synonym: "AKT" [FlyBase:FBgn0010379]
exact_synonym: "akt" [FlyBase:FBgn0010379]
exact_synonym: "Akt/PKB" [FlyBase:FBgn0010379]
exact_synonym: "AKT/PKB" [FlyBase:FBgn0010379]
exact_synonym: "Akt1" [UniProt:Q8INB9, FlyBase:FBgn0010379]
exact_synonym: "CG4006" [FlyBase:FBgn0010379]
exact_synonym: "D-Akt" [FlyBase:FBgn0010379]
exact_synonym: "DAkt" [UniProt:Q8INB9]
exact_synonym: "dAkt" [FlyBase:FBgn0010379]
exact_synonym: "Dakt" [FlyBase:FBgn0010379]
exact_synonym: "dAKT/dPKB" [FlyBase:FBgn0010379]
exact_synonym: "dAkt/PKB" [FlyBase:FBgn0010379]
exact_synonym: "Dakt1" [UniProt:Q8INB9, FlyBase:FBgn0010379]
exact_synonym: "dakt1" [FlyBase:FBgn0010379]
exact_synonym: "DAKT1" [FlyBase:FBgn0010379]
exact_synonym: "DAkt1" [FlyBase:FBgn0010379]
exact_synonym: "dAkt1" [FlyBase:FBgn0010379]
exact_synonym: "DAKT1/PKB" [FlyBase:FBgn0010379]
exact_synonym: "DPKB" [FlyBase:FBgn0010379]
exact_synonym: "dPKB" [FlyBase:FBgn0010379]
exact_synonym: "DRAC-PK" [UniProt:Q8INB9, FlyBase:FBgn0010379]
exact_synonym: "DRAC-PK66; DRAC-PK85" [FlyBase:FBgn0010379]
exact_synonym: "EC 2.7.11.1" [UniProt:Q8INB9]
exact_synonym: "l(3)04226" [FlyBase:FBgn0010379]
exact_synonym: "l(3)89Bq" [FlyBase:FBgn0010379]
exact_synonym: "PKB" [UniProt:Q8INB9, FlyBase:FBgn0010379]
exact_synonym: "PKB/Akt" [FlyBase:FBgn0010379]
exact_synonym: "PKB/AKT" [FlyBase:FBgn0010379]
exact_synonym: "PKB/dAKT" [FlyBase:FBgn0010379]
exact_synonym: "Protein kinase B" [UniProt:Q8INB9]
exact_synonym: "RAC" [FlyBase:FBgn0010379]
exact_synonym: "RAC serine/threonine-protein kinase" [UniProt:Q8INB9]
exact_synonym: "RacPK" [FlyBase:FBgn0010379]
exact_synonym: "Related to PKA to PKC protein kinases" [FlyBase:FBgn0010379]
exact_synonym: "related to the A and C kinases" [FlyBase:FBgn0010379]
xref_analog: UniProt:Q8INB9
relationship: sequence_of IMR:0000250 ! Akt

[Term]
id: IMR:0002770
name: glycogen synthase
is_a: IMR:0001379 ! glycosyltransferase

[Term]
id: IMR:0002771
name: GYS1_MOUSE
exact_synonym: "EC 2.4.1.11" [UniProt:Q9Z1E4]
exact_synonym: "Glycogen [starch] synthase, muscle" [UniProt:Q9Z1E4]
exact_synonym: "glycogen synthase 1, muscle" [MGI:101805]
exact_synonym: "Gys" [UniProt:Q9Z1E4]
exact_synonym: "Gys1" [UniProt:Q9Z1E4, MGI:101805]
exact_synonym: "Gys3" [UniProt:Q9Z1E4, MGI:101805]
exact_synonym: "MGS" [MGI:101805]
xref_analog: UniProt:Q9Z1E4
relationship: sequence_of IMR:0002770 ! glycogen synthase

[Term]
id: IMR:0002772
name: GYS2_MOUSE
exact_synonym: "EC 2.4.1.11" [UniProt:Q8VCB3]
exact_synonym: "Glycogen [starch] synthase, liver" [UniProt:Q8VCB3]
exact_synonym: "glycogen synthase 2" [MGI:2385254]
exact_synonym: "glycogen synthase, liver" [MGI:2385254]
exact_synonym: "Gys2" [MGI:2385254, UniProt:Q8VCB3]
exact_synonym: "LGS" [MGI:2385254]
xref_analog: UniProt:Q8VCB3
relationship: sequence_of IMR:0002770 ! glycogen synthase

[Term]
id: IMR:0002773
name: GYS1_RAT
exact_synonym: "EC 2.4.1.11" [UniProt:A2RRU1]
exact_synonym: "Glycogen [starch] synthase, muscle" [UniProt:A2RRU1]
exact_synonym: "glycogen synthase 1, muscle" [RGD:1589798]
exact_synonym: "Gys1" [RGD:1589798, UniProt:A2RRU1]
xref_analog: UniProt:A2RRU1
relationship: sequence_of IMR:0002770 ! glycogen synthase

[Term]
id: IMR:0002774
name: GYS2_RAT
exact_synonym: "EC 2.4.1.11" [UniProt:P17625]
exact_synonym: "Glycogen [starch] synthase, liver" [UniProt:P17625]
exact_synonym: "glycogen synthase 2" [RGD:2773]
exact_synonym: "Gys2" [RGD:2773, UniProt:P17625]
xref_analog: UniProt:P17625
relationship: sequence_of IMR:0002770 ! glycogen synthase

[Term]
id: IMR:0002775
name: AMPK
def: "AMPK is a highly evolutionarily conserved serine/threonine kinase, and orthologs of the AMPK subunits are found in all eukaryotic species. At the molecular level, AMPK is a heterotrimer complex comprising a catalytic alpha subunit, with a conventional serine/threonine protein kinase domain, and two regulatory subunits, beta and gamma. In mammals, each subunit is encoded by multiple genes (alpha1, alpha2, beta1, beta2, gamma1, gamma2, gamma3), which results in 12 possible combinations of AMPK complex." [PubMed:16644800, PubMed:17307971, PubMed:18977694]
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0002776
name: AMPK alpha subunit
is_a: IMR:0000681 ! non-receptor serine/threonine kinase
relationship: part_of IMR:0002775 ! AMPK

[Term]
id: IMR:0002777
name: AMPK beta subunit
is_a: IMR:0000429 ! enzyme regulator
relationship: part_of IMR:0002775 ! AMPK

[Term]
id: IMR:0002778
name: AMPK gamma subunit
is_a: IMR:0000429 ! enzyme regulator
relationship: part_of IMR:0002775 ! AMPK

[Term]
id: IMR:0002779
name: AAPK1_HUMAN
exact_synonym: "5'-AMP-activated protein kinase catalytic subunit alpha-1" [UniProt:Q13131]
exact_synonym: "AMP-ACTIVATED PROTEIN KINASE, CATALYTIC, ALPHA-1" [MIM:602739]
exact_synonym: "AMPK" [EntrezGene:5562]
exact_synonym: "AMPK subunit alpha-1" [UniProt:Q13131]
exact_synonym: "AMPK-ALPHA-1" [MIM:602739]
exact_synonym: "AMPK1" [UniProt:Q13131]
exact_synonym: "AMPKa1" [EntrezGene:5562, HGNC:9376]
exact_synonym: "EC 2.7.11.1" [UniProt:Q13131]
exact_synonym: "MGC33776" [EntrezGene:5562]
exact_synonym: "MGC57364" [EntrezGene:5562]
exact_synonym: "PRKAA1" [MIM:602739, UniProt:Q13131, EntrezGene:5562, HGNC:9376]
exact_synonym: "protein kinase, AMP-activated, alpha 1 catalytic subunit" [EntrezGene:5562, HGNC:9376]
exact_synonym: "PROTEIN KINASE, AMP-ACTIVATED, CATALYTIC, ALPHA-1" [MIM:602739]
xref_analog: UniProt:Q13131
relationship: sequence_of IMR:0002776 ! AMPK alpha subunit

[Term]
id: IMR:0002780
name: AAPK1_MOUSE
exact_synonym: "5'-AMP-activated protein kinase catalytic subunit alpha-1" [UniProt:Q5EG47]
exact_synonym: "AMPK subunit alpha-1" [UniProt:Q5EG47]
exact_synonym: "AMPKalpha1" [MGI:2145955]
exact_synonym: "EC 2.7.11.1" [UniProt:Q5EG47]
exact_synonym: "Prkaa1" [UniProt:Q5EG47, MGI:2145955]
exact_synonym: "protein kinase, AMP-activated, alpha 1 catalytic subunit" [MGI:2145955]
xref_analog: UniProt:Q5EG47
relationship: sequence_of IMR:0002776 ! AMPK alpha subunit

[Term]
id: IMR:0002781
name: AAPK1_RAT
exact_synonym: "5'-AMP-activated protein kinase catalytic subunit alpha-1" [UniProt:P54645]
exact_synonym: "AMPK subunit alpha-1" [UniProt:P54645]
exact_synonym: "Ampk1" [UniProt:P54645]
exact_synonym: "EC 2.7.11.1" [UniProt:P54645]
exact_synonym: "Prkaa1" [RGD:3387, UniProt:P54645]
exact_synonym: "protein kinase, AMP-activated, alpha 1 catalytic subunit" [RGD:3387]
xref_analog: UniProt:P54645
relationship: sequence_of IMR:0002776 ! AMPK alpha subunit

[Term]
id: IMR:0002782
name: AAPK2_HUMAN
exact_synonym: "5'-AMP-activated protein kinase catalytic subunit alpha-2" [UniProt:P54646]
exact_synonym: "AMP-ACTIVATED PROTEIN KINASE, CATALYTIC, ALPHA-2" [MIM:600497]
exact_synonym: "AMPK" [UniProt:P54646, HGNC:9377, EntrezGene:5563]
exact_synonym: "AMPK subunit alpha-2" [UniProt:P54646]
exact_synonym: "AMPK-ALPHA-2" [MIM:600497]
exact_synonym: "AMPK2" [UniProt:P54646, EntrezGene:5563]
exact_synonym: "EC 2.7.11.1" [UniProt:P54646]
exact_synonym: "PRKAA" [EntrezGene:5563]
exact_synonym: "PRKAA2" [UniProt:P54646, HGNC:9377, EntrezGene:5563, MIM:600497]
exact_synonym: "protein kinase, AMP-activated, alpha 2 catalytic subunit" [HGNC:9377, EntrezGene:5563]
exact_synonym: "PROTEIN KINASE, AMP-ACTIVATED, CATALYTIC, ALPHA-2" [MIM:600497]
xref_analog: UniProt:P54646
relationship: sequence_of IMR:0002776 ! AMPK alpha subunit

[Term]
id: IMR:0002783
name: AAPK2_MOUSE
exact_synonym: "5'-AMP-activated protein kinase catalytic subunit alpha-2" [UniProt:Q8BRK8]
exact_synonym: "AMPK subunit alpha-2" [UniProt:Q8BRK8]
exact_synonym: "AMPKalpha2" [MGI:1336173]
exact_synonym: "EC 2.7.11.1" [UniProt:Q8BRK8]
exact_synonym: "Prkaa2" [UniProt:Q8BRK8, MGI:1336173]
exact_synonym: "protein kinase, AMP-activated, alpha 2 catalytic subunit" [MGI:1336173]
xref_analog: UniProt:Q8BRK8
relationship: sequence_of IMR:0002776 ! AMPK alpha subunit

[Term]
id: IMR:0002784
name: AAPK2_RAT
exact_synonym: "5'-AMP-activated protein kinase catalytic subunit alpha-2" [UniProt:Q09137]
exact_synonym: "Ampk" [UniProt:Q09137]
exact_synonym: "AMPK subunit alpha-2" [UniProt:Q09137]
exact_synonym: "Ampk2" [UniProt:Q09137]
exact_synonym: "EC 2.7.11.1" [UniProt:Q09137]
exact_synonym: "Prkaa2" [RGD:620893, UniProt:Q09137]
exact_synonym: "protein kinase, AMP-activated, alpha 2 catalytic subunit" [RGD:620893]
xref_analog: UniProt:Q09137
relationship: sequence_of IMR:0002776 ! AMPK alpha subunit

[Term]
id: IMR:0002785
name: AAKB1_HUMAN
exact_synonym: "5'-AMP-activated protein kinase subunit beta-1" [UniProt:Q9Y478]
exact_synonym: "AMP-ACTIVATED PROTEIN KINASE, NONCATALYTIC, BETA-1" [MIM:602740]
exact_synonym: "AMPK" [UniProt:Q9Y478, EntrezGene:5564]
exact_synonym: "AMPK subunit beta-1" [UniProt:Q9Y478]
exact_synonym: "AMPK-BETA-1" [MIM:602740]
exact_synonym: "AMPKb" [UniProt:Q9Y478]
exact_synonym: "HAMPKb" [EntrezGene:5564]
exact_synonym: "MGC17785" [EntrezGene:5564]
exact_synonym: "PRKAB1" [UniProt:Q9Y478, MIM:602740, EntrezGene:5564, HGNC:9378]
exact_synonym: "protein kinase, AMP-activated, beta 1 non-catalytic subunit" [EntrezGene:5564, HGNC:9378]
exact_synonym: "PROTEIN KINASE, AMP-ACTIVATED, NONCATALYTIC, BETA-1" [MIM:602740]
xref_analog: UniProt:Q9Y478
relationship: sequence_of IMR:0002777 ! AMPK beta subunit

[Term]
id: IMR:0002786
name: AAKB1_MOUSE
exact_synonym: "5'-AMP-activated protein kinase subunit beta-1" [UniProt:Q9R078]
exact_synonym: "AMPK subunit beta-1" [UniProt:Q9R078]
exact_synonym: "AMPKb" [UniProt:Q9R078]
exact_synonym: "Prkab1" [UniProt:Q9R078, MGI:1336167]
exact_synonym: "protein kinase, AMP-activated, beta 1 non-catalytic subunit" [MGI:1336167]
xref_analog: UniProt:Q9R078
relationship: sequence_of IMR:0002777 ! AMPK beta subunit

[Term]
id: IMR:0002787
name: AAKB1_RAT
exact_synonym: "5'-AMP-activated protein kinase 40 kDa subunit" [UniProt:P80386]
exact_synonym: "5'-AMP-activated protein kinase subunit beta-1" [UniProt:P80386]
exact_synonym: "AMPK subunit beta-1" [UniProt:P80386]
exact_synonym: "AMPKb" [UniProt:P80386]
exact_synonym: "Prkab1" [UniProt:P80386, RGD:71057]
exact_synonym: "protein kinase, AMP-activated, beta 1 non-catalytic subunit" [RGD:71057]
xref_analog: UniProt:P80386
relationship: sequence_of IMR:0002777 ! AMPK beta subunit

[Term]
id: IMR:0002788
name: AAKB2_HUMAN
exact_synonym: "5'-AMP-activated protein kinase subunit beta-2" [UniProt:O43741]
exact_synonym: "AMP-ACTIVATED PROTEIN KINASE, NONCATALYTIC, BETA-2" [MIM:602741]
exact_synonym: "AMPK subunit beta-2" [UniProt:O43741]
exact_synonym: "AMPK-BETA-2" [MIM:602741]
exact_synonym: "MGC61468" [EntrezGene:5565]
exact_synonym: "PRKAB2" [MIM:602741, HGNC:9379, UniProt:O43741, EntrezGene:5565]
exact_synonym: "protein kinase, AMP-activated, beta 2 non-catalytic subunit" [HGNC:9379, EntrezGene:5565]
exact_synonym: "PROTEIN KINASE, AMP-ACTIVATED, NONCATALYTIC, BETA-2" [MIM:602741]
xref_analog: UniProt:O43741
relationship: sequence_of IMR:0002777 ! AMPK beta subunit

[Term]
id: IMR:0002789
name: AAKB2_MOUSE
exact_synonym: "5'-AMP-activated protein kinase subunit beta-2" [UniProt:Q6PAM0]
exact_synonym: "AMPK subunit beta-2" [UniProt:Q6PAM0]
exact_synonym: "Prkab2" [UniProt:Q6PAM0, MGI:1336185]
exact_synonym: "protein kinase, AMP-activated, beta 2 non-catalytic subunit" [MGI:1336185]
xref_analog: UniProt:Q6PAM0
relationship: sequence_of IMR:0002777 ! AMPK beta subunit

[Term]
id: IMR:0002790
name: AAKB2_RAT
exact_synonym: "5'-AMP-activated protein kinase subunit beta-2" [UniProt:Q9QZH4]
exact_synonym: "AMPK subunit beta-2" [UniProt:Q9QZH4]
exact_synonym: "Prkab2" [RGD:620905, UniProt:Q9QZH4]
exact_synonym: "protein kinase, AMP-activated, beta 2 non-catalytic subunit" [RGD:620905]
xref_analog: UniProt:Q9QZH4
relationship: sequence_of IMR:0002777 ! AMPK beta subunit

[Term]
id: IMR:0002791
name: AAKG1_HUMAN
exact_synonym: "5'-AMP-activated protein kinase subunit gamma-1" [UniProt:P54619]
exact_synonym: "AMP-ACTIVATED PROTEIN KINASE, NONCATALYTIC, GAMMA-1" [MIM:602742]
exact_synonym: "AMPK gamma1" [UniProt:P54619]
exact_synonym: "AMPK subunit gamma-1" [UniProt:P54619]
exact_synonym: "AMPK-GAMMA-1" [MIM:602742]
exact_synonym: "AMPKg" [UniProt:P54619]
exact_synonym: "AMPKG" [EntrezGene:5571]
exact_synonym: "MGC8666" [EntrezGene:5571]
exact_synonym: "PRKAG1" [HGNC:9385, UniProt:P54619, MIM:602742, EntrezGene:5571]
exact_synonym: "protein kinase, AMP-activated, gamma 1 non-catalytic subunit" [HGNC:9385, EntrezGene:5571]
exact_synonym: "PROTEIN KINASE, AMP-ACTIVATED, NONCATALYTIC, GAMMA-1" [MIM:602742]
xref_analog: UniProt:P54619
relationship: sequence_of IMR:0002778 ! AMPK gamma subunit

[Term]
id: IMR:0002792
name: AAKG1_MOUSE
exact_synonym: "5'-AMP-activated protein kinase subunit gamma-1" [UniProt:O54950]
exact_synonym: "AMPK gamma1" [UniProt:O54950]
exact_synonym: "AMPK subunit gamma-1" [UniProt:O54950]
exact_synonym: "AMPKg" [UniProt:O54950]
exact_synonym: "Prkaac" [UniProt:O54950, MGI:108411]
exact_synonym: "Prkag1" [UniProt:O54950, MGI:108411]
exact_synonym: "protein kinase, AMP-activated, gamma 1 non-catalytic subunit" [MGI:108411]
xref_analog: UniProt:O54950
relationship: sequence_of IMR:0002778 ! AMPK gamma subunit

[Term]
id: IMR:0002793
name: AAKG1_RAT
exact_synonym: "5'-AMP-activated protein kinase subunit gamma-1" [UniProt:P80385]
exact_synonym: "AMPK gamma1" [UniProt:P80385]
exact_synonym: "AMPK subunit gamma-1" [UniProt:P80385]
exact_synonym: "AMPKg" [UniProt:P80385]
exact_synonym: "Prkag1" [RGD:3388, UniProt:P80385]
exact_synonym: "protein kinase, AMP-activated, gamma 1 non-catalytic subunit" [RGD:3388]
xref_analog: UniProt:P80385
relationship: sequence_of IMR:0002778 ! AMPK gamma subunit

[Term]
id: IMR:0002794
name: AAKG2_HUMAN
exact_synonym: "5'-AMP-activated protein kinase subunit gamma-2" [UniProt:Q9UGJ0]
exact_synonym: "AAKG" [HGNC:9386, EntrezGene:51422]
exact_synonym: "AAKG2" [HGNC:9386, EntrezGene:51422]
exact_synonym: "AMP-ACTIVATED PROTEIN KINASE, NONCATALYTIC, GAMMA-2" [MIM:602743]
exact_synonym: "AMPK gamma2" [UniProt:Q9UGJ0]
exact_synonym: "AMPK subunit gamma-2" [UniProt:Q9UGJ0]
exact_synonym: "AMPK-GAMMA-2" [MIM:602743]
exact_synonym: "CMH6" [HGNC:9386, EntrezGene:51422]
exact_synonym: "H91620p" [UniProt:Q9UGJ0, HGNC:9386, EntrezGene:51422]
exact_synonym: "PRKAG2" [MIM:602743, UniProt:Q9UGJ0, HGNC:9386, EntrezGene:51422]
exact_synonym: "protein kinase, AMP-activated, gamma 2 non-catalytic subunit" [HGNC:9386, EntrezGene:51422]
exact_synonym: "PROTEIN KINASE, AMP-ACTIVATED, NONCATALYTIC, GAMMA-2" [MIM:602743]
exact_synonym: "WPWS" [HGNC:9386, EntrezGene:51422]
xref_analog: UniProt:Q9UGJ0
relationship: sequence_of IMR:0002778 ! AMPK gamma subunit

[Term]
id: IMR:0002795
name: AAKG2_MOUSE
exact_synonym: "5'-AMP-activated protein kinase subunit gamma-2" [UniProt:Q91WG5]
exact_synonym: "AMPK gamma2" [UniProt:Q91WG5]
exact_synonym: "AMPK subunit gamma-2" [UniProt:Q91WG5]
exact_synonym: "Prkag2" [UniProt:Q91WG5, MGI:1336153]
exact_synonym: "protein kinase, AMP-activated, gamma 2 non-catalytic subunit" [MGI:1336153]
xref_analog: UniProt:Q91WG5
relationship: sequence_of IMR:0002778 ! AMPK gamma subunit

[Term]
id: IMR:0002796
name: AAKG3_HUMAN
exact_synonym: "5'-AMP-activated protein kinase subunit gamma-3" [UniProt:Q9UGI9]
exact_synonym: "AMPK gamma3" [UniProt:Q9UGI9]
exact_synonym: "AMPK subunit gamma-3" [UniProt:Q9UGI9]
exact_synonym: "AMPKG3" [EntrezGene:53632, UniProt:Q9UGI9]
exact_synonym: "PRKAG3" [EntrezGene:53632, UniProt:Q9UGI9, HGNC:9387]
exact_synonym: "protein kinase, AMP-activated, gamma 3 non-catalytic subunit" [EntrezGene:53632, HGNC:9387]
xref_analog: UniProt:Q9UGI9
relationship: sequence_of IMR:0002778 ! AMPK gamma subunit

[Term]
id: IMR:0002797
name: AAKG3_MOUSE
exact_synonym: "5'-AMP-activated protein kinase subunit gamma-3" [UniProt:Q8BGM7]
exact_synonym: "AMPK gamma3" [UniProt:Q8BGM7]
exact_synonym: "AMPK subunit gamma-3" [UniProt:Q8BGM7]
exact_synonym: "AMPKg3" [MGI:1891343]
exact_synonym: "AMPKg3L" [MGI:1891343]
exact_synonym: "AMPKg3S" [MGI:1891343]
exact_synonym: "Prkag3" [MGI:1891343, UniProt:Q8BGM7]
exact_synonym: "protein kinase, AMP-activated, gamma 3 non-catatlytic subunit" [MGI:1891343]
xref_analog: UniProt:Q8BGM7
relationship: sequence_of IMR:0002778 ! AMPK gamma subunit

[Term]
id: IMR:0002798
name: S6K1
is_a: IMR:0001845 ! p70S6K

[Term]
id: IMR:0002799
name: S6K2
is_a: IMR:0001845 ! p70S6K

[Term]
id: IMR:0002800
name: KS6B1_HUMAN
exact_synonym: "70 kDa ribosomal protein S6 kinase 1" [UniProt:P23443]
exact_synonym: "EC 2.7.11.1" [UniProt:P23443]
exact_synonym: "p70 ribosomal S6 kinase alpha" [UniProt:P23443]
exact_synonym: "p70 S6 kinase alpha" [UniProt:P23443]
exact_synonym: "p70 S6 KINASE, ALPHA" [MIM:608938]
exact_synonym: "p70 S6K-alpha" [UniProt:P23443]
exact_synonym: "p70 S6KA" [UniProt:P23443]
exact_synonym: "p70(S6K)-alpha" [MIM:608938, HGNC:10436, EntrezGene:6198]
exact_synonym: "p70-ALPHA" [MIM:608938]
exact_synonym: "p70-alpha" [EntrezGene:6198]
exact_synonym: "p70-S6K" [EntrezGene:6198]
exact_synonym: "p70-S6K 1" [UniProt:P23443]
exact_synonym: "P70S6K1" [UniProt:P23443]
exact_synonym: "PS6K" [HGNC:10436, EntrezGene:6198]
exact_synonym: "Ribosomal protein S6 kinase beta-1" [UniProt:P23443]
exact_synonym: "Ribosomal protein S6 kinase I" [UniProt:P23443]
exact_synonym: "RIBOSOMAL PROTEIN S6 KINASE, 70-KD, 1" [MIM:608938]
exact_synonym: "ribosomal protein S6 kinase, 70kDa, polypeptide 1" [HGNC:10436, EntrezGene:6198]
exact_synonym: "RPS6KB1" [MIM:608938, HGNC:10436, EntrezGene:6198, UniProt:P23443]
exact_synonym: "S6K" [EntrezGene:6198]
exact_synonym: "S6K-beta-1" [UniProt:P23443]
exact_synonym: "S6K1" [MIM:608938, HGNC:10436, EntrezGene:6198, UniProt:P23443]
exact_synonym: "Serine/threonine-protein kinase 14A" [UniProt:P23443]
exact_synonym: "STK14A" [EntrezGene:6198, UniProt:P23443]
xref_analog: UniProt:P23443
relationship: sequence_of IMR:0002798 ! S6K1

[Term]
id: IMR:0002801
name: KS6B1_MOUSE
exact_synonym: "70 kDa ribosomal protein S6 kinase 1" [UniProt:Q8BSK8]
exact_synonym: "EC 2.7.11.1" [UniProt:Q8BSK8]
exact_synonym: "p70 ribosomal S6 kinase alpha" [UniProt:Q8BSK8]
exact_synonym: "p70 S6 kinase alpha" [UniProt:Q8BSK8]
exact_synonym: "p70 S6K-alpha" [UniProt:Q8BSK8]
exact_synonym: "p70 S6KA" [UniProt:Q8BSK8]
exact_synonym: "p70-S6K 1" [UniProt:Q8BSK8]
exact_synonym: "p70/85s6k" [MGI:1270849]
exact_synonym: "p70s6k" [MGI:1270849]
exact_synonym: "P70S6K1" [UniProt:Q8BSK8]
exact_synonym: "Ribosomal protein S6 kinase beta-1" [UniProt:Q8BSK8]
exact_synonym: "Ribosomal protein S6 kinase I" [UniProt:Q8BSK8]
exact_synonym: "ribosomal protein S6 kinase, polypeptide 1" [MGI:1270849]
exact_synonym: "Rps6kb1" [MGI:1270849, UniProt:Q8BSK8]
exact_synonym: "S6K" [UniProt:Q8BSK8]
exact_synonym: "S6K-beta-1" [UniProt:Q8BSK8]
exact_synonym: "S6K1" [MGI:1270849, UniProt:Q8BSK8]
xref_analog: UniProt:Q8BSK8
relationship: sequence_of IMR:0002798 ! S6K1

[Term]
id: IMR:0002802
name: KS6B1_RAT
exact_synonym: "70 kDa ribosomal protein S6 kinase 1" [UniProt:P67999]
exact_synonym: "EC 2.7.11.1" [UniProt:P67999]
exact_synonym: "p70 ribosomal S6 kinase alpha" [UniProt:P67999]
exact_synonym: "p70 S6 kinase alpha" [UniProt:P67999]
exact_synonym: "p70 S6K-alpha" [UniProt:P67999]
exact_synonym: "p70 S6KA" [UniProt:P67999]
exact_synonym: "p70-S6K 1" [UniProt:P67999]
exact_synonym: "P70S6K1" [UniProt:P67999]
exact_synonym: "Ribosomal protein S6 kinase beta-1" [UniProt:P67999]
exact_synonym: "Ribosomal protein S6 kinase I" [UniProt:P67999]
exact_synonym: "ribosomal protein S6 kinase, 70kDa, polypeptide 1" [RGD:620683]
exact_synonym: "Rps6kb1" [RGD:620683, UniProt:P67999]
exact_synonym: "S6K-beta-1" [UniProt:P67999]
exact_synonym: "S6K1" [UniProt:P67999]
xref_analog: UniProt:P67999
relationship: sequence_of IMR:0002798 ! S6K1

[Term]
id: IMR:0002803
name: Q94533_DROME
exact_synonym: "7084" [FlyBase:FBgn0015806]
exact_synonym: "CG10539" [FlyBase:FBgn0015806]
exact_synonym: "Dp70[s6k]" [FlyBase:FBgn0015806]
exact_synonym: "dp70[S6k]" [FlyBase:FBgn0015806]
exact_synonym: "Dp70S6k" [FlyBase:FBgn0015806]
exact_synonym: "Dp70s6k" [FlyBase:FBgn0015806]
exact_synonym: "dp70s6k" [FlyBase:FBgn0015806]
exact_synonym: "dps6k" [FlyBase:FBgn0015806]
exact_synonym: "dS6 kinase" [FlyBase:FBgn0015806]
exact_synonym: "dS6K" [FlyBase:FBgn0015806]
exact_synonym: "DS6K" [FlyBase:FBgn0015806]
exact_synonym: "ds6k" [FlyBase:FBgn0015806]
exact_synonym: "dS6k" [FlyBase:FBgn0015806]
exact_synonym: "EC 2.7.11.-" [UniProt:Q94533]
exact_synonym: "fs(3)07084" [FlyBase:FBgn0015806]
exact_synonym: "l(3)07084" [FlyBase:FBgn0015806]
exact_synonym: "p70 S6K" [FlyBase:FBgn0015806]
exact_synonym: "p70[S6 kinase]" [FlyBase:FBgn0015806]
exact_synonym: "p70[S6k]" [FlyBase:FBgn0015806]
exact_synonym: "p70[S6kinase]" [FlyBase:FBgn0015806]
exact_synonym: "p70S6K" [FlyBase:FBgn0015806]
exact_synonym: "p70s6K" [FlyBase:FBgn0015806]
exact_synonym: "P70s6k protein kinase homolog" [UniProt:Q94533]
exact_synonym: "RPS6-p70-protein kinase" [UniProt:Q94533, FlyBase:FBgn0015806]
exact_synonym: "S6 kinase" [FlyBase:FBgn0015806]
exact_synonym: "S6k" [UniProt:Q94533, FlyBase:FBgn0015806]
exact_synonym: "S6K" [FlyBase:FBgn0015806]
exact_synonym: "s6k11" [FlyBase:FBgn0015806]
exact_synonym: "S6kinase" [FlyBase:FBgn0015806]
xref_analog: UniProt:Q94533
relationship: sequence_of IMR:0001845 ! p70S6K

[Term]
id: IMR:0002804
name: FOXO
def: "FOXO proteins are conserved from worm to human. To date, only one FOXO species has been identified in invertebrates (called dauer formation-16 in Caenorhabditis elegans and dFOXO in Drosophila). In mammals, four subfamily members have been identified: FOXO1 (previously known as FKHR), FOXO3 (previously known as FKHRL1), FOXO4 (previously known as AFX) and FOXO6." [PubMed:18391973]
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0002805
name: FOXO1
is_a: IMR:0002804 ! FOXO

[Term]
id: IMR:0002806
name: FOXO3
is_a: IMR:0002804 ! FOXO

[Term]
id: IMR:0002807
name: FOXO4
is_a: IMR:0002804 ! FOXO

[Term]
id: IMR:0002808
name: FOXO6
is_a: IMR:0002804 ! FOXO

[Term]
id: IMR:0002809
name: FOXO1_HUMAN
exact_synonym: "FKH1" [HGNC:3819, EntrezGene:2308]
exact_synonym: "FKHR" [UniProt:Q12778, EntrezGene:2308, MIM:136533]
exact_synonym: "forkhead box O1" [HGNC:3819, EntrezGene:2308]
exact_synonym: "FORKHEAD BOX O1A" [MIM:136533]
exact_synonym: "Forkhead box protein O1" [UniProt:Q12778]
exact_synonym: "Forkhead box protein O1A" [UniProt:Q12778]
exact_synonym: "Forkhead in rhabdomyosarcoma" [UniProt:Q12778, MIM:136533]
exact_synonym: "FORKHEAD, DROSOPHILA, HOMOLOG OF, IN RHABDOMYOSARCOMA" [MIM:136533]
exact_synonym: "FOXO1" [HGNC:3819, UniProt:Q12778, EntrezGene:2308, MIM:136533]
exact_synonym: "FOXO1A" [UniProt:Q12778, EntrezGene:2308, MIM:136533]
xref_analog: UniProt:Q12778
relationship: sequence_of IMR:0002805 ! FOXO1

[Term]
id: IMR:0002810
name: FOXO1_MOUSE
exact_synonym: "Afxh" [MGI:1890077]
exact_synonym: "Fkhr" [UniProt:Q9R1E0]
exact_synonym: "FKHR" [MGI:1890077]
exact_synonym: "Fkhr1" [MGI:1890077]
exact_synonym: "forkhead box O1" [MGI:1890077]
exact_synonym: "Forkhead box protein O1" [UniProt:Q9R1E0]
exact_synonym: "Forkhead box protein O1A" [UniProt:Q9R1E0]
exact_synonym: "Forkhead in rhabdomyosarcoma" [UniProt:Q9R1E0]
exact_synonym: "Foxo1" [MGI:1890077, UniProt:Q9R1E0]
exact_synonym: "Foxo1a" [MGI:1890077, UniProt:Q9R1E0]
xref_analog: UniProt:Q9R1E0
relationship: sequence_of IMR:0002805 ! FOXO1

[Term]
id: IMR:0002811
name: FOXO3_HUMAN
exact_synonym: "AF6q21" [HGNC:3821, EntrezGene:2309]
exact_synonym: "AF6q21 protein" [UniProt:O43524]
exact_synonym: "DKFZp781A0677" [EntrezGene:2309]
exact_synonym: "FKHR-LIKE 1" [MIM:602681]
exact_synonym: "FKHRL1" [UniProt:O43524, MIM:602681, EntrezGene:2309]
exact_synonym: "FKHRL1P2" [EntrezGene:2309]
exact_synonym: "forkhead box O3" [HGNC:3821, EntrezGene:2309]
exact_synonym: "FORKHEAD BOX O3A" [MIM:602681]
exact_synonym: "Forkhead box protein O3" [UniProt:O43524]
exact_synonym: "Forkhead in rhabdomyosarcoma-like 1" [UniProt:O43524, MIM:602681]
exact_synonym: "FOXO2" [HGNC:3821, EntrezGene:2309]
exact_synonym: "FOXO3" [HGNC:3821, UniProt:O43524, MIM:602681, EntrezGene:2309]
exact_synonym: "FOXO3A" [UniProt:O43524, MIM:602681, EntrezGene:2309]
exact_synonym: "MGC12739" [EntrezGene:2309]
exact_synonym: "MGC31925" [EntrezGene:2309]
xref_analog: UniProt:O43524
relationship: sequence_of IMR:0002806 ! FOXO3

[Term]
id: IMR:0002812
name: Q9WVH4_MOUSE
exact_synonym: "Fkhr2" [UniProt:Q9WVH4, MGI:1890081]
exact_synonym: "FKHRL1" [MGI:1890081]
exact_synonym: "forkhead box O3" [MGI:1890081]
exact_synonym: "Forkhead box O3a" [UniProt:Q9WVH4]
exact_synonym: "Forkhead protein FKHR2" [UniProt:Q9WVH4]
exact_synonym: "Foxo3" [UniProt:Q9WVH4, MGI:1890081]
exact_synonym: "Foxo3a" [UniProt:Q9WVH4, MGI:1890081]
xref_analog: UniProt:Q9WVH4
relationship: sequence_of IMR:0002806 ! FOXO3

[Term]
id: IMR:0002813
name: FOXO4_HUMAN
exact_synonym: "AFX" [UniProt:P98177, EntrezGene:4303]
exact_synonym: "AFX1" [HGNC:7139, UniProt:P98177, EntrezGene:4303, MIM:300033]
exact_synonym: "ALL1-FUSED GENE FROM X CHROMOSOME" [MIM:300033]
exact_synonym: "Fork head domain transcription factor AFX1" [UniProt:P98177]
exact_synonym: "forkhead box O4" [HGNC:7139, EntrezGene:4303, MIM:300033]
exact_synonym: "Forkhead box protein O4" [UniProt:P98177]
exact_synonym: "FOXO4" [HGNC:7139, UniProt:P98177, EntrezGene:4303, MIM:300033]
exact_synonym: "MGC120490" [EntrezGene:4303]
exact_synonym: "MIXED LINEAGE LEUKEMIA, TRANSLOCATED TO, 7" [MIM:300033]
exact_synonym: "MLLT7" [UniProt:P98177, EntrezGene:4303, MIM:300033]
exact_synonym: "MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA, TRANSLOCATED TO, 7" [MIM:300033]
xref_analog: UniProt:P98177
relationship: sequence_of IMR:0002807 ! FOXO4

[Term]
id: IMR:0002814
name: FOXO4_MOUSE
exact_synonym: "Afx" [UniProt:Q9WVH3]
exact_synonym: "afx" [MGI:1891915]
exact_synonym: "Afx1" [UniProt:Q9WVH3]
exact_synonym: "Afxh" [MGI:1891915, UniProt:Q9WVH3]
exact_synonym: "Fkhr3" [UniProt:Q9WVH3]
exact_synonym: "Fork head domain transcription factor AFX1" [UniProt:Q9WVH3]
exact_synonym: "forkhead box O4" [MGI:1891915]
exact_synonym: "Forkhead box protein O4" [UniProt:Q9WVH3]
exact_synonym: "Foxo4" [MGI:1891915, UniProt:Q9WVH3]
exact_synonym: "Mllt7" [MGI:1891915, UniProt:Q9WVH3]
xref_analog: UniProt:Q9WVH3
relationship: sequence_of IMR:0002807 ! FOXO4

[Term]
id: IMR:0002815
name: FOXO6_HUMAN
exact_synonym: "forkhead box O6" [HGNC:24814, MIM:611457, EntrezGene:100132074]
exact_synonym: "Forkhead box protein O6" [UniProt:A8MYZ6]
exact_synonym: "FOXO6" [UniProt:A8MYZ6, HGNC:24814, MIM:611457, EntrezGene:100132074]
xref_analog: UniProt:A8MYZ6
relationship: sequence_of IMR:0002808 ! FOXO6

[Term]
id: IMR:0002816
name: FOXO6_MOUSE
exact_synonym: "forkhead box O6" [MGI:2676586]
exact_synonym: "Forkhead box protein O6" [UniProt:Q70KY4]
exact_synonym: "Foxo6" [UniProt:Q70KY4, MGI:2676586]
xref_analog: UniProt:Q70KY4
relationship: sequence_of IMR:0002808 ! FOXO6

[Term]
id: IMR:0002817
name: FOXO_DROME
exact_synonym: "Afx" [UniProt:Q95V55, FlyBase:FBgn0038197]
exact_synonym: "anon-WO0118547.374" [FlyBase:FBgn0038197]
exact_synonym: "cg3143" [FlyBase:FBgn0038197]
exact_synonym: "CG3143" [FlyBase:FBgn0038197]
exact_synonym: "dFOXO" [UniProt:Q95V55, FlyBase:FBgn0038197]
exact_synonym: "Dfoxo" [FlyBase:FBgn0038197]
exact_synonym: "dFoxo" [FlyBase:FBgn0038197]
exact_synonym: "DmQ95V5" [FlyBase:FBgn0038197]
exact_synonym: "FKHR" [FlyBase:FBgn0038197]
exact_synonym: "Forkhead box protein O" [UniProt:Q95V55]
exact_synonym: "forkhead box, sub-group O" [FlyBase:FBgn0038197]
exact_synonym: "foxo" [UniProt:Q95V55, FlyBase:FBgn0038197]
exact_synonym: "FOXO" [FlyBase:FBgn0038197]
exact_synonym: "Foxo" [FlyBase:FBgn0038197]
exact_synonym: "Protein FKHR" [UniProt:Q95V55]
exact_synonym: "Q95V55" [FlyBase:FBgn0038197]
xref_analog: UniProt:Q95V55
relationship: sequence_of IMR:0002804 ! FOXO

[Term]
id: IMR:0002818
name: rapamycin
xref_analog: KEGG:C07909
is_a: IMR:0001998 ! unclassified chemical

[Term]
id: IMR:0002819
name: Ski/HHAT
is_a: IMR:0000955 ! acyltransferase

[Term]
id: IMR:0002820
name: HHAT_HUMAN
exact_synonym: "EC 2.3.1.-" [UniProt:Q5VTY9]
exact_synonym: "FLJ10724" [EntrezGene:55733, HGNC:18270]
exact_synonym: "FLJ34867" [EntrezGene:55733]
exact_synonym: "GUP2" [HGNC:18270]
exact_synonym: "Hedgehog acyltransferase" [UniProt:Q5VTY9, MIM:605743]
exact_synonym: "hedgehog acyltransferase" [EntrezGene:55733, HGNC:18270]
exact_synonym: "HHAT" [EntrezGene:55733, UniProt:Q5VTY9, HGNC:18270, MIM:605743]
exact_synonym: "MART-2" [UniProt:Q5VTY9, HGNC:18270]
exact_synonym: "MART2" [EntrezGene:55733, UniProt:Q5VTY9, HGNC:18270, MIM:605743]
exact_synonym: "MELANOMA ANTIGEN RECOGNIZED BY T CELLS 2" [MIM:605743]
exact_synonym: "Melanoma antigen recognized by T-cells 2" [UniProt:Q5VTY9]
exact_synonym: "Protein-cysteine N-palmitoyltransferase HHAT" [UniProt:Q5VTY9]
exact_synonym: "rasp" [HGNC:18270]
exact_synonym: "sit" [HGNC:18270]
exact_synonym: "ski" [HGNC:18270]
exact_synonym: "SKI1" [EntrezGene:55733, UniProt:Q5VTY9, MIM:605743]
exact_synonym: "Skinny hedgehog protein 1" [UniProt:Q5VTY9]
exact_synonym: "SKINNY HEDGEHOG, DROSOPHILA, HOMOLOG OF" [MIM:605743]
exact_synonym: "Skn" [EntrezGene:55733, HGNC:18270]
xref_analog: UniProt:Q5VTY9
relationship: sequence_of IMR:0002819 ! Ski/HHAT

[Term]
id: IMR:0002821
name: HHAT_MOUSE
exact_synonym: "EC 2.3.1.-" [UniProt:Q8BMT9]
exact_synonym: "Hedgehog acyltransferase" [UniProt:Q8BMT9]
exact_synonym: "hedgehog acyltransferase" [MGI:2444681]
exact_synonym: "Hhat" [MGI:2444681, UniProt:Q8BMT9]
exact_synonym: "Protein-cysteine N-palmitoyltransferase HHAT" [UniProt:Q8BMT9]
exact_synonym: "Skinny hedgehog protein" [UniProt:Q8BMT9]
exact_synonym: "Skn" [MGI:2444681, UniProt:Q8BMT9]
xref_analog: UniProt:Q8BMT9
relationship: sequence_of IMR:0002819 ! Ski/HHAT

[Term]
id: IMR:0002822
name: HHAT_DROME
exact_synonym: "7F21" [FlyBase:FBgn0024194]
exact_synonym: "central missing" [FlyBase:FBgn0024194]
exact_synonym: "CG11495" [FlyBase:FBgn0024194]
exact_synonym: "cmn" [UniProt:Q9VZU2, FlyBase:FBgn0024194]
exact_synonym: "EC 2.3.1.-" [UniProt:Q9VZU2]
exact_synonym: "l(3)63Bg" [FlyBase:FBgn0024194]
exact_synonym: "l(3)m47" [FlyBase:FBgn0024194]
exact_synonym: "l(3)M47" [FlyBase:FBgn0024194]
exact_synonym: "l(3)SG3" [FlyBase:FBgn0024194]
exact_synonym: "lethal(3)63Bg" [FlyBase:FBgn0024194]
exact_synonym: "lethal(3)SG3" [FlyBase:FBgn0024194]
exact_synonym: "Protein central missing" [UniProt:Q9VZU2]
exact_synonym: "Protein sightless" [UniProt:Q9VZU2]
exact_synonym: "Protein skinny hedgehog" [UniProt:Q9VZU2]
exact_synonym: "Protein-cysteine N-palmitoyltransferase Rasp" [UniProt:Q9VZU2]
exact_synonym: "rasp" [UniProt:Q9VZU2, FlyBase:FBgn0024194]
exact_synonym: "Rasp" [FlyBase:FBgn0024194]
exact_synonym: "rsp" [FlyBase:FBgn0024194]
exact_synonym: "sig/ski" [FlyBase:FBgn0024194]
exact_synonym: "sightless" [FlyBase:FBgn0024194]
exact_synonym: "sit" [UniProt:Q9VZU2, FlyBase:FBgn0024194]
exact_synonym: "ski" [UniProt:Q9VZU2, FlyBase:FBgn0024194]
exact_synonym: "ski/sit" [FlyBase:FBgn0024194]
exact_synonym: "skinny hedgehog" [FlyBase:FBgn0024194]
xref_analog: UniProt:Q9VZU2
relationship: sequence_of IMR:0002819 ! Ski/HHAT

[Term]
id: IMR:0002823
name: PRAS40
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0002824
name: AKTS1_HUMAN
exact_synonym: "40 kDa proline-rich AKT substrate" [UniProt:Q96B36]
exact_synonym: "AKT1 substrate 1 (proline-rich)" [HGNC:28426, EntrezGene:84335]
exact_synonym: "AKT1 SUBSTRATE 1, PROLINE-RICH" [MIM:610221]
exact_synonym: "AKT1S1" [MIM:610221, HGNC:28426, UniProt:Q96B36, EntrezGene:84335]
exact_synonym: "Lobe" [HGNC:28426, EntrezGene:84335]
exact_synonym: "MGC2865" [MIM:610221, HGNC:28426, EntrezGene:84335]
exact_synonym: "PRAS40" [MIM:610221, HGNC:28426, UniProt:Q96B36, EntrezGene:84335]
exact_synonym: "PROLINE-RICH AKT SUBSTRATE, 40-KD" [MIM:610221]
exact_synonym: "Proline-rich AKT1 substrate 1" [UniProt:Q96B36]
xref_analog: UniProt:Q96B36
relationship: sequence_of IMR:0002823 ! PRAS40

[Term]
id: IMR:0002825
name: AKTS1_MOUSE
exact_synonym: "AKT1 substrate 1 (proline-rich)" [MGI:1914855]
exact_synonym: "Akt1s1" [UniProt:Q9D1F4, MGI:1914855]
exact_synonym: "Lobe" [MGI:1914855]
exact_synonym: "Pras" [UniProt:Q9D1F4]
exact_synonym: "PRAS40" [MGI:1914855]
exact_synonym: "Proline-rich AKT substrate" [UniProt:Q9D1F4]
exact_synonym: "Proline-rich AKT1 substrate 1" [UniProt:Q9D1F4]
xref_analog: UniProt:Q9D1F4
relationship: sequence_of IMR:0002823 ! PRAS40

[Term]
id: IMR:0002826
name: FKBP38
is_a: IMR:0100476 ! FKBP

[Term]
id: IMR:0002827
name: FKBP8_HUMAN
exact_synonym: "38 kDa FK506-binding protein" [UniProt:Q14318]
exact_synonym: "38 kDa FKBP" [UniProt:Q14318]
exact_synonym: "EC 5.2.1.8" [UniProt:Q14318]
exact_synonym: "FK506 binding protein 8, 38kDa" [EntrezGene:23770, HGNC:3724]
exact_synonym: "FK506-binding protein 8" [UniProt:Q14318, MIM:604840]
exact_synonym: "FK506-BINDING PROTEIN, 38-KD" [MIM:604840]
exact_synonym: "FKBP-38" [UniProt:Q14318]
exact_synonym: "FKBP-8" [UniProt:Q14318]
exact_synonym: "FKBP38" [EntrezGene:23770, UniProt:Q14318, HGNC:3724, MIM:604840]
exact_synonym: "FKBP8" [EntrezGene:23770, UniProt:Q14318, HGNC:3724, MIM:604840]
exact_synonym: "FKBPR38" [UniProt:Q14318]
exact_synonym: "FKBPr38" [EntrezGene:23770, HGNC:3724]
exact_synonym: "hFKBP38" [UniProt:Q14318]
exact_synonym: "Peptidyl-prolyl cis-trans isomerase FKBP8" [UniProt:Q14318]
exact_synonym: "PPIase FKBP8" [UniProt:Q14318]
exact_synonym: "Rotamase" [UniProt:Q14318]
xref_analog: UniProt:Q14318
relationship: sequence_of IMR:0002826 ! FKBP38

[Term]
id: IMR:0002828
name: FKBP8_MOUSE
exact_synonym: "38 kDa FK506-binding protein" [UniProt:O35465]
exact_synonym: "38 kDa FKBP" [UniProt:O35465]
exact_synonym: "38kDa" [MGI:1341070]
exact_synonym: "EC 5.2.1.8" [UniProt:O35465]
exact_synonym: "FK506 binding protein 8" [MGI:1341070]
exact_synonym: "FK506-binding protein 8" [UniProt:O35465]
exact_synonym: "FKBP-38" [UniProt:O35465]
exact_synonym: "FKBP-8" [UniProt:O35465]
exact_synonym: "Fkbp38" [UniProt:O35465, MGI:1341070]
exact_synonym: "Fkbp8" [UniProt:O35465, MGI:1341070]
exact_synonym: "FKBPR38" [UniProt:O35465]
exact_synonym: "mFKBP38" [UniProt:O35465]
exact_synonym: "Peptidyl-prolyl cis-trans isomerase FKBP8" [UniProt:O35465]
exact_synonym: "PPIase FKBP8" [UniProt:O35465]
exact_synonym: "Rotamase" [UniProt:O35465]
exact_synonym: "Sam11" [UniProt:O35465]
xref_analog: UniProt:O35465
relationship: sequence_of IMR:0002826 ! FKBP38

[Term]
id: IMR:0002829
name: Q9XZ56_DROME
exact_synonym: "4E-binding protein THOR" [UniProt:Q9XZ56]
exact_synonym: "4E-BP" [FlyBase:FBgn0261560]
exact_synonym: "4E-BP1" [FlyBase:FBgn0261560]
exact_synonym: "4EBP" [FlyBase:FBgn0261560]
exact_synonym: "anon-WO0172774.158" [FlyBase:FBgn0261560]
exact_synonym: "BcDNA.HL08053" [FlyBase:FBgn0261560]
exact_synonym: "BcDNA:HL08053" [FlyBase:FBgn0261560]
exact_synonym: "CG8846" [FlyBase:FBgn0261560]
exact_synonym: "CT8705" [FlyBase:FBgn0261560]
exact_synonym: "d4E-BP" [FlyBase:FBgn0261560]
exact_synonym: "d4E-BP1" [FlyBase:FBgn0261560]
exact_synonym: "d4EBP" [FlyBase:FBgn0261560]
exact_synonym: "Dm 4E-BP" [FlyBase:FBgn0261560]
exact_synonym: "eIF-4E-binding protein" [FlyBase:FBgn0261560]
exact_synonym: "eIF4E-BP" [FlyBase:FBgn0261560]
exact_synonym: "HL08053p" [UniProt:Q9XZ56]
exact_synonym: "insulin-stimulated eIF-4E binding protein" [FlyBase:FBgn0261560]
exact_synonym: "l(2)k07736" [FlyBase:FBgn0261560]
exact_synonym: "l(2)k13517" [FlyBase:FBgn0261560]
exact_synonym: "Phas1" [FlyBase:FBgn0261560]
exact_synonym: "pp20" [FlyBase:FBgn0261560]
exact_synonym: "Thor" [UniProt:Q9XZ56, FlyBase:FBgn0261560]
exact_synonym: "thor" [FlyBase:FBgn0261560]
xref_analog: UniProt:Q9XZ56
relationship: sequence_of IMR:0000898 ! 4E-BP

[Term]
id: IMR:0002830
name: IF4A_DROME
exact_synonym: "2439" [FlyBase:FBgn0001942]
exact_synonym: "anon-26Aa" [FlyBase:FBgn0001942]
exact_synonym: "anon26A" [FlyBase:FBgn0001942]
exact_synonym: "ATP-dependent RNA helicase eIF4A" [UniProt:Q02748]
exact_synonym: "CG9075" [FlyBase:FBgn0001942]
exact_synonym: "Dm-eIF4A" [FlyBase:FBgn0001942]
exact_synonym: "DmRH2" [FlyBase:FBgn0001942]
exact_synonym: "EC 3.6.4.13" [UniProt:Q02748]
exact_synonym: "eIF-4A" [FlyBase:FBgn0001942, UniProt:Q02748]
exact_synonym: "eIF-4a" [FlyBase:FBgn0001942, UniProt:Q02748]
exact_synonym: "EIF-4A" [FlyBase:FBgn0001942]
exact_synonym: "Eif-4a" [FlyBase:FBgn0001942]
exact_synonym: "eif-4a" [FlyBase:FBgn0001942]
exact_synonym: "eIF4A" [FlyBase:FBgn0001942, UniProt:Q02748]
exact_synonym: "Eif4a" [FlyBase:FBgn0001942]
exact_synonym: "eif4A" [FlyBase:FBgn0001942]
exact_synonym: "EiF4A" [FlyBase:FBgn0001942]
exact_synonym: "Eukaryotic initiation factor 4A" [UniProt:Q02748]
exact_synonym: "Eukaryotic initiation factor 4a" [FlyBase:FBgn0001942]
exact_synonym: "l(2)02439" [FlyBase:FBgn0001942]
exact_synonym: "l(2)162" [FlyBase:FBgn0001942]
exact_synonym: "l(2)26Ac" [FlyBase:FBgn0001942]
exact_synonym: "l(2)gdh-4" [FlyBase:FBgn0001942]
exact_synonym: "l(2)k01501" [FlyBase:FBgn0001942]
exact_synonym: "l(2L)162" [FlyBase:FBgn0001942, UniProt:Q02748]
xref_analog: UniProt:Q02748
relationship: sequence_of IMR:0000906 ! eIF4A

[Term]
id: IMR:0002831
name: IF4E_DROME
exact_synonym: "0260/09" [FlyBase:FBgn0015218]
exact_synonym: "0587/11" [FlyBase:FBgn0015218]
exact_synonym: "0589/11" [FlyBase:FBgn0015218]
exact_synonym: "0919/12" [FlyBase:FBgn0015218]
exact_synonym: "1004/13" [FlyBase:FBgn0015218]
exact_synonym: "7238" [FlyBase:FBgn0015218]
exact_synonym: "cap binding protein" [FlyBase:FBgn0015218]
exact_synonym: "CBP" [FlyBase:FBgn0015218]
exact_synonym: "CG4035" [FlyBase:FBgn0015218]
exact_synonym: "CT13384" [FlyBase:FBgn0015218]
exact_synonym: "CT39424" [FlyBase:FBgn0015218]
exact_synonym: "CT39426" [FlyBase:FBgn0015218]
exact_synonym: "D-eIF4E" [FlyBase:FBgn0015218]
exact_synonym: "deIF4E" [FlyBase:FBgn0015218]
exact_synonym: "eIF-4E" [UniProt:P48598, FlyBase:FBgn0015218]
exact_synonym: "eif-4E" [FlyBase:FBgn0015218]
exact_synonym: "eIF-4e" [FlyBase:FBgn0015218]
exact_synonym: "eIF-4E1,2" [FlyBase:FBgn0015218]
exact_synonym: "eIF-4EII" [FlyBase:FBgn0015218]
exact_synonym: "eIF-4F 25 kDa subunit" [UniProt:P48598]
exact_synonym: "eIF4E" [UniProt:P48598, FlyBase:FBgn0015218]
exact_synonym: "Eif4e" [UniProt:P48598, FlyBase:FBgn0015218]
exact_synonym: "eIF4e" [FlyBase:FBgn0015218]
exact_synonym: "Eif4E" [FlyBase:FBgn0015218]
exact_synonym: "EIF4F" [UniProt:P48598]
exact_synonym: "eukaryotic initiation factor 4E" [FlyBase:FBgn0015218]
exact_synonym: "Eukaryotic initiation factor 4E" [FlyBase:FBgn0015218]
exact_synonym: "Eukaryotic translation initiation factor 4E" [UniProt:P48598]
exact_synonym: "IF4E" [FlyBase:FBgn0015218]
exact_synonym: "l(3)07238" [FlyBase:FBgn0015218]
exact_synonym: "l(3)67Af" [FlyBase:FBgn0015218]
exact_synonym: "l(3)S025007" [FlyBase:FBgn0015218]
exact_synonym: "l(3)S026009" [FlyBase:FBgn0015218]
exact_synonym: "l(3)S058711" [FlyBase:FBgn0015218]
exact_synonym: "l(3)S091912" [FlyBase:FBgn0015218]
exact_synonym: "lethal(3)67Af" [FlyBase:FBgn0015218]
exact_synonym: "mRNA cap-binding protein" [UniProt:P48598]
xref_analog: UniProt:P48598
relationship: sequence_of IMR:0011155 ! eIF4E

[Term]
id: IMR:0002832
name: O61380_DROME
exact_synonym: "eIF-4G" [UniProt:O61380]
exact_synonym: "eIF4G" [FlyBase:FBgn0023213, UniProt:O61380]
exact_synonym: "eIF4G-RA" [UniProt:O61380]
exact_synonym: "eukaryotic translation initiation factor 4G" [FlyBase:FBgn0023213]
exact_synonym: "Eukaryotic translation initiation factor 4G, isoform A" [UniProt:O61380]
exact_synonym: "Eukaryotic translation initiation factor 4G, isoform C" [UniProt:O61380]
exact_synonym: "FI02056p" [UniProt:O61380]
exact_synonym: "Translation initiation factor eIF4G" [UniProt:O61380]
xref_analog: UniProt:O61380
relationship: sequence_of IMR:0000910 ! eIF4G

[Term]
id: IMR:0002833
name: GTR1_DROME
exact_synonym: "CG1086" [FlyBase:FBgn0261914]
exact_synonym: "Dmglut1" [FlyBase:FBgn0261914]
exact_synonym: "GLU" [FlyBase:FBgn0261914]
exact_synonym: "glucose transporter 1" [FlyBase:FBgn0261914]
exact_synonym: "Glucose transporter 1" [FlyBase:FBgn0261914]
exact_synonym: "Glucose transporter type 1" [UniProt:Q8IRI6]
exact_synonym: "Glut1" [FlyBase:FBgn0261914, UniProt:Q8IRI6]
exact_synonym: "glut1" [FlyBase:FBgn0261914]
xref_analog: UniProt:Q8IRI6
relationship: sequence_of IMR:0000921 ! glucose transporter

[Term]
id: IMR:0002834
name: GTR3_DROME
exact_synonym: "CG3853" [FlyBase:FBgn0015230]
exact_synonym: "GLU" [FlyBase:FBgn0015230]
exact_synonym: "Glucose transporter type 3" [UniProt:P53403, FlyBase:FBgn0015230]
exact_synonym: "Glucose transporter-like" [FlyBase:FBgn0015230]
exact_synonym: "Glucose transporter-like protein" [UniProt:P53403]
exact_synonym: "glut-l" [UniProt:P53403, FlyBase:FBgn0015230]
exact_synonym: "Glut3" [UniProt:P53403, FlyBase:FBgn0015230]
xref_analog: UniProt:P53403
relationship: sequence_of IMR:0000921 ! glucose transporter

[Term]
id: IMR:0002835
name: insulin family
def: "Insulin superfamily genes are ubiquitous in vertebrates, and have been identified in invertebrates, including insects, molluscs, and the nematode Caenorhabditis elegans. Seven members of the insulin superfamily have been identified in humans, including insulin, insulin-like growth factors (IGFs) I and II, relaxins HI and HII, early placenta insulin-like peptide (EPIL), and relaxin-like factor." [PubMed:11274053]
is_a: IMR:0100046 ! peptide hormone

[Term]
id: IMR:0002836
name: DILP
def: "In Drosophila, there are seven DILPs that are expressed in several different tissues. All DILPs display a higher degree of overall amino-acid identity with human insulin than with human IGFs, DILP2 being most closely related with 35% identity to human preproinsulin." [PubMed:17373657, PubMed:18682271]
exact_synonym: "Drosophila insulin-like peptide" []
is_a: IMR:0002835 ! insulin family

[Term]
id: IMR:0002837
name: IGF1_MOUSE
exact_synonym: "Igf-1" [MGI:96432, UniProt:P05017]
exact_synonym: "IGF-I" [UniProt:P05017]
exact_synonym: "Igf-I" [MGI:96432]
exact_synonym: "Igf1" [MGI:96432, UniProt:P05017]
exact_synonym: "insulin-like growth factor 1" [MGI:96432]
exact_synonym: "Insulin-like growth factor I" [UniProt:P05017]
exact_synonym: "Somatomedin" [UniProt:P05017]
xref_analog: UniProt:P05017
relationship: sequence_of IMR:0100144 ! insulin-like growth factor I

[Term]
id: IMR:0002838
name: IGF1_RAT
exact_synonym: "Igf-1" [UniProt:P08025]
exact_synonym: "IGF-I" [UniProt:P08025]
exact_synonym: "Igf1" [RGD:2868, UniProt:P08025]
exact_synonym: "insulin-like growth factor 1" [RGD:2868]
exact_synonym: "Insulin-like growth factor I" [UniProt:P08025]
exact_synonym: "Somatomedin" [UniProt:P08025]
xref_analog: UniProt:P08025
relationship: sequence_of IMR:0100144 ! insulin-like growth factor I

[Term]
id: IMR:0002839
name: IGF2_HUMAN
exact_synonym: "C11orf43" [EntrezGene:3481]
exact_synonym: "FLJ22066" [EntrezGene:3481]
exact_synonym: "FLJ44734" [EntrezGene:3481, HGNC:5466]
exact_synonym: "IGF-II" [EntrezGene:3481, UniProt:P01344]
exact_synonym: "IGF2" [EntrezGene:3481, UniProt:P01344, HGNC:5466]
exact_synonym: "insulin-like growth factor 2 (somatomedin A)" [EntrezGene:3481, HGNC:5466]
exact_synonym: "Insulin-like growth factor II" [UniProt:P01344]
exact_synonym: "Insulin-like growth factor II Ala-25 Del" [UniProt:P01344]
exact_synonym: "PP9974" [EntrezGene:3481]
exact_synonym: "Preptin" [UniProt:P01344]
exact_synonym: "Somatomedin-A" [UniProt:P01344]
xref_analog: UniProt:P01344
relationship: sequence_of IMR:0100145 ! insulin-like growth factor II

[Term]
id: IMR:0002840
name: IGF2_MOUSE
exact_synonym: "Igf-2" [UniProt:P09535, MGI:96434]
exact_synonym: "IGF-II" [UniProt:P09535]
exact_synonym: "Igf-II" [MGI:96434]
exact_synonym: "Igf2" [UniProt:P09535, MGI:96434]
exact_synonym: "insulin-like growth factor 2" [MGI:96434]
exact_synonym: "Insulin-like growth factor II" [UniProt:P09535]
exact_synonym: "M6pr" [MGI:96434]
exact_synonym: "Mpr" [MGI:96434]
exact_synonym: "Multiplication-stimulating polypeptide" [UniProt:P09535]
exact_synonym: "Peg2" [MGI:96434]
exact_synonym: "Preptin" [UniProt:P09535]
xref_analog: UniProt:P09535
relationship: sequence_of IMR:0100145 ! insulin-like growth factor II

[Term]
id: IMR:0002841
name: IGF2_RAT
exact_synonym: "Igf-2" [UniProt:P01346]
exact_synonym: "IGF-II" [UniProt:P01346]
exact_synonym: "Igf2" [RGD:2870, UniProt:P01346]
exact_synonym: "insulin-like growth factor 2" [RGD:2870]
exact_synonym: "Insulin-like growth factor II" [UniProt:P01346]
exact_synonym: "MSA" [UniProt:P01346]
exact_synonym: "Multiplication-stimulating activity" [UniProt:P01346]
exact_synonym: "Multiplication-stimulating polypeptide" [UniProt:P01346]
exact_synonym: "Preptin" [UniProt:P01346]
xref_analog: UniProt:P01346
relationship: sequence_of IMR:0100145 ! insulin-like growth factor II

[Term]
id: IMR:0002842
name: INSL1_DROME
exact_synonym: "CG14173" [FlyBase:FBgn0044051]
exact_synonym: "dilp" [FlyBase:FBgn0044051]
exact_synonym: "Dilp" [FlyBase:FBgn0044051]
exact_synonym: "DILP" [FlyBase:FBgn0044051]
exact_synonym: "Dilp 1" [FlyBase:FBgn0044051]
exact_synonym: "dilp-1" [FlyBase:FBgn0044051]
exact_synonym: "dILP1" [UniProt:Q9VT50]
exact_synonym: "DILP1" [FlyBase:FBgn0044051]
exact_synonym: "dilp1" [FlyBase:FBgn0044051]
exact_synonym: "Drosophila insulin-like peptide 1" [FlyBase:FBgn0044051]
exact_synonym: "Ilp1" [FlyBase:FBgn0044051, UniProt:Q9VT50]
exact_synonym: "Insulin-like peptide 1" [FlyBase:FBgn0044051]
exact_synonym: "Insulin-related peptide 1" [UniProt:Q9VT50]
exact_synonym: "Probable insulin-like peptide 1" [UniProt:Q9VT50]
exact_synonym: "Probable insulin-like peptide 1 A chain" [UniProt:Q9VT50]
exact_synonym: "Probable insulin-like peptide 1 B chain" [UniProt:Q9VT50]
xref_analog: UniProt:Q9VT50
relationship: sequence_of IMR:0002836 ! DILP

[Term]
id: IMR:0002843
name: INSL2_DROME
exact_synonym: "CG8167" [FlyBase:FBgn0036046]
exact_synonym: "dilp" [FlyBase:FBgn0036046]
exact_synonym: "Dilp" [FlyBase:FBgn0036046]
exact_synonym: "DILP" [FlyBase:FBgn0036046]
exact_synonym: "Dilp 2" [FlyBase:FBgn0036046]
exact_synonym: "dilp-2" [FlyBase:FBgn0036046]
exact_synonym: "dILP2" [UniProt:Q9VT51, FlyBase:FBgn0036046]
exact_synonym: "DILP2" [FlyBase:FBgn0036046]
exact_synonym: "Dilp2" [FlyBase:FBgn0036046]
exact_synonym: "dilp2" [FlyBase:FBgn0036046]
exact_synonym: "Drosophila insulin-like peptide 2" [FlyBase:FBgn0036046]
exact_synonym: "Ilp2" [UniProt:Q9VT51, FlyBase:FBgn0036046]
exact_synonym: "ILP2" [FlyBase:FBgn0036046]
exact_synonym: "insulin-like peptide 2" [FlyBase:FBgn0036046]
exact_synonym: "Insulin-like peptide 2" [FlyBase:FBgn0036046]
exact_synonym: "Insulin-related peptide 2" [UniProt:Q9VT51]
exact_synonym: "IRP" [UniProt:Q9VT51, FlyBase:FBgn0036046]
exact_synonym: "Probable insulin-like peptide 2" [UniProt:Q9VT51]
exact_synonym: "Probable insulin-like peptide 2 A chain" [UniProt:Q9VT51]
exact_synonym: "Probable insulin-like peptide 2 B chain" [UniProt:Q9VT51]
xref_analog: UniProt:Q9VT51
relationship: sequence_of IMR:0002836 ! DILP

[Term]
id: IMR:0002844
name: INSL3_DROME
exact_synonym: "CG14167" [FlyBase:FBgn0044050]
exact_synonym: "dilp" [FlyBase:FBgn0044050]
exact_synonym: "Dilp" [FlyBase:FBgn0044050]
exact_synonym: "DILP" [FlyBase:FBgn0044050]
exact_synonym: "Dilp 3" [FlyBase:FBgn0044050]
exact_synonym: "dilp-3" [FlyBase:FBgn0044050]
exact_synonym: "dILP3" [UniProt:Q9VT52]
exact_synonym: "DILP3" [FlyBase:FBgn0044050]
exact_synonym: "dilp3" [FlyBase:FBgn0044050]
exact_synonym: "Drosophila insulin-like peptide 3" [FlyBase:FBgn0044050]
exact_synonym: "Ilp3" [FlyBase:FBgn0044050, UniProt:Q9VT52]
exact_synonym: "Insulin-like peptide 3" [FlyBase:FBgn0044050]
exact_synonym: "Insulin-related peptide 3" [UniProt:Q9VT52]
exact_synonym: "Probable insulin-like peptide 3" [UniProt:Q9VT52]
exact_synonym: "Probable insulin-like peptide 3 A chain" [UniProt:Q9VT52]
exact_synonym: "Probable insulin-like peptide 3 B chain" [UniProt:Q9VT52]
xref_analog: UniProt:Q9VT52
relationship: sequence_of IMR:0002836 ! DILP

[Term]
id: IMR:0002845
name: INSL4_DROME
exact_synonym: "A" [FlyBase:FBgn0044049]
exact_synonym: "anon-EST:CLB3" [FlyBase:FBgn0044049]
exact_synonym: "BcDNA:RE27042" [FlyBase:FBgn0044049]
exact_synonym: "CG6736" [FlyBase:FBgn0044049]
exact_synonym: "dilp" [FlyBase:FBgn0044049]
exact_synonym: "Dilp" [FlyBase:FBgn0044049]
exact_synonym: "DILP" [FlyBase:FBgn0044049]
exact_synonym: "Dilp 4" [FlyBase:FBgn0044049]
exact_synonym: "dilp-4" [FlyBase:FBgn0044049]
exact_synonym: "dILP4" [UniProt:Q9VT53]
exact_synonym: "DILP4" [FlyBase:FBgn0044049]
exact_synonym: "dilp4" [FlyBase:FBgn0044049]
exact_synonym: "Dirlp" [FlyBase:FBgn0044049]
exact_synonym: "Drosophila insulin-like peptide 4" [FlyBase:FBgn0044049]
exact_synonym: "Drosophila insulin/relaxin-like peptide" [FlyBase:FBgn0044049]
exact_synonym: "Ilp4" [FlyBase:FBgn0044049, UniProt:Q9VT53]
exact_synonym: "Insulin-like peptide 4" [FlyBase:FBgn0044049]
exact_synonym: "Insulin-related peptide 4" [UniProt:Q9VT53]
exact_synonym: "Mes3" [FlyBase:FBgn0044049]
exact_synonym: "Probable insulin-like peptide 4" [UniProt:Q9VT53]
exact_synonym: "Probable insulin-like peptide 4 A chain" [UniProt:Q9VT53]
exact_synonym: "Probable insulin-like peptide 4 B chain" [UniProt:Q9VT53]
xref_analog: UniProt:Q9VT53
relationship: sequence_of IMR:0002836 ! DILP

[Term]
id: IMR:0002846
name: INSL5_DROME
exact_synonym: "CG33273" [FlyBase:FBgn0044048]
exact_synonym: "dilp" [FlyBase:FBgn0044048]
exact_synonym: "Dilp" [FlyBase:FBgn0044048]
exact_synonym: "DILP" [FlyBase:FBgn0044048]
exact_synonym: "Dilp 5" [FlyBase:FBgn0044048]
exact_synonym: "dilp-5" [FlyBase:FBgn0044048]
exact_synonym: "dILP5" [UniProt:Q7KUD5]
exact_synonym: "DILP5" [FlyBase:FBgn0044048]
exact_synonym: "dilp5" [FlyBase:FBgn0044048]
exact_synonym: "Drosophila insulin-like peptide 5" [FlyBase:FBgn0044048]
exact_synonym: "HDC09365" [UniProt:Q7KUD5]
exact_synonym: "Ilp5" [UniProt:Q7KUD5, FlyBase:FBgn0044048]
exact_synonym: "Insulin-like peptide 5" [FlyBase:FBgn0044048]
exact_synonym: "Insulin-related peptide 5" [UniProt:Q7KUD5]
exact_synonym: "Probable insulin-like peptide 5" [UniProt:Q7KUD5]
exact_synonym: "Probable insulin-like peptide 5 A chain" [UniProt:Q7KUD5]
exact_synonym: "Probable insulin-like peptide 5 B chain" [UniProt:Q7KUD5]
xref_analog: UniProt:Q7KUD5
relationship: sequence_of IMR:0002836 ! DILP

[Term]
id: IMR:0002847
name: INSL6_DROME
exact_synonym: "CG14049" [FlyBase:FBgn0044047]
exact_synonym: "dilp" [FlyBase:FBgn0044047]
exact_synonym: "Dilp" [FlyBase:FBgn0044047]
exact_synonym: "DILP" [FlyBase:FBgn0044047]
exact_synonym: "Dilp 6" [FlyBase:FBgn0044047]
exact_synonym: "dilp-6" [FlyBase:FBgn0044047]
exact_synonym: "dILP6" [UniProt:Q9W4Z4]
exact_synonym: "dilp6" [FlyBase:FBgn0044047]
exact_synonym: "Drosophila insulin-like peptide 6" [FlyBase:FBgn0044047]
exact_synonym: "Ilp6" [UniProt:Q9W4Z4, FlyBase:FBgn0044047]
exact_synonym: "Insulin-like peptide 6" [FlyBase:FBgn0044047]
exact_synonym: "Insulin-related peptide 6" [UniProt:Q9W4Z4]
exact_synonym: "Probable insulin-like peptide 6" [UniProt:Q9W4Z4]
exact_synonym: "Probable insulin-like peptide 6 A chain" [UniProt:Q9W4Z4]
exact_synonym: "Probable insulin-like peptide 6 B chain" [UniProt:Q9W4Z4]
xref_analog: UniProt:Q9W4Z4
relationship: sequence_of IMR:0002836 ! DILP

[Term]
id: IMR:0002848
name: INSL7_DROME
exact_synonym: "CG13317" [FlyBase:FBgn0044046]
exact_synonym: "dilp" [FlyBase:FBgn0044046]
exact_synonym: "Dilp" [FlyBase:FBgn0044046]
exact_synonym: "DILP" [FlyBase:FBgn0044046]
exact_synonym: "Dilp 7" [FlyBase:FBgn0044046]
exact_synonym: "dilp-7" [FlyBase:FBgn0044046]
exact_synonym: "dILP7" [UniProt:Q9W4Q9]
exact_synonym: "dilp7" [FlyBase:FBgn0044046]
exact_synonym: "Drosophila insulin-like peptide 7" [FlyBase:FBgn0044046]
exact_synonym: "Ilp7" [FlyBase:FBgn0044046, UniProt:Q9W4Q9]
exact_synonym: "Insulin-like peptide 7" [FlyBase:FBgn0044046]
exact_synonym: "Insulin-related peptide 7" [UniProt:Q9W4Q9]
exact_synonym: "Probable insulin-like peptide 7" [UniProt:Q9W4Q9]
exact_synonym: "Probable insulin-like peptide 7 A chain" [UniProt:Q9W4Q9]
exact_synonym: "Probable insulin-like peptide 7 B chain" [UniProt:Q9W4Q9]
xref_analog: UniProt:Q9W4Q9
relationship: sequence_of IMR:0002836 ! DILP

[Term]
id: IMR:0002849
name: IRS1_DROME
exact_synonym: "anon-WO0078940.1" [FlyBase:FBgn0024248]
exact_synonym: "anon-WO0078940.4" [FlyBase:FBgn0024248]
exact_synonym: "BcDNA.GH11263" [FlyBase:FBgn0024248]
exact_synonym: "BcDNA:GH11263" [FlyBase:FBgn0024248]
exact_synonym: "CG5686" [FlyBase:FBgn0024248]
exact_synonym: "chic" [FlyBase:FBgn0024248]
exact_synonym: "chico" [FlyBase:FBgn0024248, UniProt:Q9XTN2]
exact_synonym: "CHICO" [FlyBase:FBgn0024248]
exact_synonym: "dIRS" [FlyBase:FBgn0024248, UniProt:Q9XTN2]
exact_synonym: "flipper" [FlyBase:FBgn0024248]
exact_synonym: "fs(2)4" [FlyBase:FBgn0024248]
exact_synonym: "fs(2)ry4" [FlyBase:FBgn0024248]
exact_synonym: "Insulin receptor substrate 1" [UniProt:Q9XTN2]
exact_synonym: "IRS" [FlyBase:FBgn0024248, UniProt:Q9XTN2]
exact_synonym: "Protein chico" [UniProt:Q9XTN2]
xref_analog: UniProt:Q9XTN2
relationship: sequence_of IMR:0000351 ! IRS

[Term]
id: IMR:0002850
name: P91634_DROME
exact_synonym: "anon-92Ed" [FlyBase:FBgn0015279]
exact_synonym: "CG4141" [FlyBase:FBgn0015279]
exact_synonym: "Dmp110" [FlyBase:FBgn0015279]
exact_synonym: "dp110" [FlyBase:FBgn0015279]
exact_synonym: "Dp110" [FlyBase:FBgn0015279]
exact_synonym: "Dp110/PI3K" [FlyBase:FBgn0015279]
exact_synonym: "dPI 3-kinase" [FlyBase:FBgn0015279]
exact_synonym: "dPI3K" [FlyBase:FBgn0015279]
exact_synonym: "EC 2.7.1.-" [UniProt:P91634]
exact_synonym: "EC 2.7.1.137" [UniProt:P91634]
exact_synonym: "EC 2.7.1.153" [UniProt:P91634]
exact_synonym: "EC 2.7.1.154" [UniProt:P91634]
exact_synonym: "p110" [FlyBase:FBgn0015279]
exact_synonym: "p110 PI3 kinase" [FlyBase:FBgn0015279]
exact_synonym: "p120" [FlyBase:FBgn0015279]
exact_synonym: "Phosphoinositide 3-kinase, Dp110" [UniProt:P91634]
exact_synonym: "phosphoinositide 3-kinase." [FlyBase:FBgn0015279]
exact_synonym: "PI 3-kinase" [FlyBase:FBgn0015279]
exact_synonym: "PI(3)K" [FlyBase:FBgn0015279]
exact_synonym: "PI-3-K" [FlyBase:FBgn0015279]
exact_synonym: "PI3 kinase" [FlyBase:FBgn0015279]
exact_synonym: "PI3-kinase" [FlyBase:FBgn0015279]
exact_synonym: "PI3K" [FlyBase:FBgn0015279]
exact_synonym: "PI3K-92D" [FlyBase:FBgn0015279]
exact_synonym: "PI3K-92E/Dp110" [FlyBase:FBgn0015279]
exact_synonym: "Pi3K92D" [FlyBase:FBgn0015279]
exact_synonym: "Pi3K92E" [UniProt:P91634, FlyBase:FBgn0015279]
exact_synonym: "Pi3K92E, isoform A" [UniProt:P91634]
exact_synonym: "Pi3K92E, isoform B" [UniProt:P91634]
exact_synonym: "Pi3Kp110" [FlyBase:FBgn0015279]
exact_synonym: "rea" [FlyBase:FBgn0015279]
exact_synonym: "SD05105p" [UniProt:P91634]
exact_synonym: "type-1 PI3K" [FlyBase:FBgn0015279]
xref_analog: UniProt:P91634
relationship: sequence_of IMR:0000265 ! PI3-kinase

[Term]
id: IMR:0002851
name: O18683_DROME
exact_synonym: "CG2699" [FlyBase:FBgn0020622]
exact_synonym: "dPI 3-kinase" [FlyBase:FBgn0020622]
exact_synonym: "dPI3K" [FlyBase:FBgn0020622]
exact_synonym: "droPIK57" [FlyBase:FBgn0020622, UniProt:O18683]
exact_synonym: "LD42724p" [UniProt:O18683]
exact_synonym: "p60" [FlyBase:FBgn0020622, UniProt:O18683]
exact_synonym: "P60 protein" [UniProt:O18683]
exact_synonym: "Phosphatidylinositol 3-kinase regulatory subunit" [UniProt:O18683]
exact_synonym: "PI 3-kinase" [FlyBase:FBgn0020622]
exact_synonym: "PI(3)K" [FlyBase:FBgn0020622]
exact_synonym: "PI3-kinase" [FlyBase:FBgn0020622]
exact_synonym: "PI3K" [FlyBase:FBgn0020622]
exact_synonym: "Pi3K21B" [FlyBase:FBgn0020622, UniProt:O18683]
exact_synonym: "Pi3Kp60" [FlyBase:FBgn0020622]
xref_analog: UniProt:O18683
relationship: sequence_of IMR:0000429 ! enzyme regulator

[Term]
id: IMR:0002852
name: PDPK1_DROME
exact_synonym: "3-phosphoinositide-dependent protein kinase 1" [UniProt:Q9W0V1]
exact_synonym: "CG1201" [FlyBase:FBgn0020386]
exact_synonym: "CG1210" [FlyBase:FBgn0020386]
exact_synonym: "dPDK-1" [UniProt:Q9W0V1, FlyBase:FBgn0020386]
exact_synonym: "dPDK1" [FlyBase:FBgn0020386]
exact_synonym: "dSTPK61" [UniProt:Q9W0V1, FlyBase:FBgn0020386]
exact_synonym: "DSTPK61" [FlyBase:FBgn0020386]
exact_synonym: "Dstpk61" [FlyBase:FBgn0020386]
exact_synonym: "EC 2.7.11.1" [UniProt:Q9W0V1]
exact_synonym: "PDK" [FlyBase:FBgn0020386]
exact_synonym: "PDK-1" [FlyBase:FBgn0020386]
exact_synonym: "PDK1" [UniProt:Q9W0V1, FlyBase:FBgn0020386]
exact_synonym: "Pdk1" [FlyBase:FBgn0020386]
exact_synonym: "Phosphoinositide dependent kinase 1" [FlyBase:FBgn0020386]
exact_synonym: "Pk61C" [UniProt:Q9W0V1, FlyBase:FBgn0020386]
exact_synonym: "Protein kinase 61C" [FlyBase:FBgn0020386]
exact_synonym: "serine/threonine protein kinase." [FlyBase:FBgn0020386]
exact_synonym: "Serine/threonine-protein kinase 61C" [UniProt:Q9W0V1]
xref_analog: UniProt:Q9W0V1
relationship: sequence_of IMR:0000255 ! PDK

[Term]
id: IMR:0002853
name: PDPK1_CAEEL
exact_synonym: "3-phosphoinositide-dependent protein kinase 1" [UniProt:Q9Y1J3]
exact_synonym: "EC 2.7.11.1" [UniProt:Q9Y1J3]
exact_synonym: "pdk-1" [UniProt:Q9Y1J3]
exact_synonym: "Pdk-class protein kinase 1" [UniProt:Q9Y1J3]
xref_analog: UniProt:Q9Y1J3
relationship: sequence_of IMR:0000255 ! PDK

[Term]
id: IMR:0002854
name: TCTP_DROME
exact_synonym: "CG4800" [FlyBase:FBgn0037874]
exact_synonym: "dTCTP" [FlyBase:FBgn0037874]
exact_synonym: "TCTP" [FlyBase:FBgn0037874, UniProt:Q9VGS2]
exact_synonym: "Tctp" [FlyBase:FBgn0037874, UniProt:Q9VGS2]
exact_synonym: "Translationally controlled tumor protein" [FlyBase:FBgn0037874]
exact_synonym: "Translationally-controlled tumor protein homolog" [UniProt:Q9VGS2]
xref_analog: UniProt:Q9VGS2
relationship: sequence_of IMR:0000433 ! GEF

[Term]
id: IMR:0002855
name: Q9V3L4_DROME
exact_synonym: "CG5671" [FlyBase:FBgn0026379]
exact_synonym: "dPTEN" [FlyBase:FBgn0026379]
exact_synonym: "DPTEN" [FlyBase:FBgn0026379]
exact_synonym: "EC 3.1.3.-" [UniProt:Q9V3L4]
exact_synonym: "EC 3.1.3.16" [UniProt:Q9V3L4]
exact_synonym: "EC 3.1.3.48" [UniProt:Q9V3L4]
exact_synonym: "EC 3.1.3.67" [UniProt:Q9V3L4]
exact_synonym: "Phosphatase and tensin homolog" [UniProt:Q9V3L4]
exact_synonym: "PTEN" [FlyBase:FBgn0026379, UniProt:Q9V3L4]
exact_synonym: "Pten" [FlyBase:FBgn0026379, UniProt:Q9V3L4]
exact_synonym: "pten" [FlyBase:FBgn0026379]
exact_synonym: "Pten, isoform A" [UniProt:Q9V3L4]
exact_synonym: "Pten, isoform E" [UniProt:Q9V3L4]
exact_synonym: "PTEN3" [FlyBase:FBgn0026379, UniProt:Q9V3L4]
xref_analog: UniProt:Q9V3L4
relationship: sequence_of IMR:0100701 ! PTEN

[Term]
id: IMR:0002856
name: O44405_CAEEL
exact_synonym: "Abnormal dauer formation protein 18" [UniProt:O44405]
exact_synonym: "DAF-18" [UniProt:O44405]
exact_synonym: "daf-18" [UniProt:O44405]
exact_synonym: "DAF-18 protein" [UniProt:O44405]
exact_synonym: "PTEN phosphatidylinositol 3' phosphatase homolog DAF-18" [UniProt:O44405]
xref_analog: UniProt:O44405
relationship: sequence_of IMR:0100701 ! PTEN

[Term]
id: IMR:0002857
name: MELT_DROME
exact_synonym: "1441/14" [FlyBase:FBgn0023001]
exact_synonym: "anon-WO03014152.10" [FlyBase:FBgn0023001]
exact_synonym: "CG8624" [FlyBase:FBgn0023001]
exact_synonym: "melt" [UniProt:Q9VS24, FlyBase:FBgn0023001]
exact_synonym: "melted" [FlyBase:FBgn0023001]
exact_synonym: "Protein melted" [UniProt:Q9VS24]
xref_analog: UniProt:Q9VS24
relationship: sequence_of IMR:0000428 ! signal regulator

[Term]
id: IMR:0002858
name: AGE1_CAEEL
exact_synonym: "age-1" [UniProt:Q94125]
exact_synonym: "Aging alteration protein 1" [UniProt:Q94125]
exact_synonym: "EC 2.7.1.137" [UniProt:Q94125]
exact_synonym: "Phosphatidylinositol 3-kinase age-1" [UniProt:Q94125]
exact_synonym: "PI3-kinase age-1" [UniProt:Q94125]
exact_synonym: "PI3K age-1" [UniProt:Q94125]
exact_synonym: "PtdIns-3-kinase age-1" [UniProt:Q94125]
xref_analog: UniProt:Q94125
relationship: sequence_of IMR:0000265 ! PI3-kinase

[Term]
id: IMR:0002859
name: Q9N597_CAEEL
exact_synonym: "aap-1" [UniProt:Q9N597]
exact_synonym: "Phosphoinositide 3-kinase adapter subunit" [UniProt:Q9N597]
exact_synonym: "Phosphoinositide kinase adapter subunit protein 1" [UniProt:Q9N597]
xref_analog: UniProt:Q9N597
relationship: sequence_of IMR:0000429 ! enzyme regulator

[Term]
id: IMR:0002860
name: AKT1_CAEEL
exact_synonym: "akt-1" [UniProt:Q17941]
exact_synonym: "EC 2.7.11.1" [UniProt:Q17941]
exact_synonym: "PKB akt-1" [UniProt:Q17941]
exact_synonym: "Protein kinase B akt-1" [UniProt:Q17941]
exact_synonym: "Serine/threonine-protein kinase akt-1" [UniProt:Q17941]
xref_analog: UniProt:Q17941
relationship: sequence_of IMR:0000250 ! Akt

[Term]
id: IMR:0002861
name: AKT2_CAEEL
exact_synonym: "akt-2" [UniProt:Q9XTG7]
exact_synonym: "EC 2.7.11.1" [UniProt:Q9XTG7]
exact_synonym: "PKB akt-2" [UniProt:Q9XTG7]
exact_synonym: "Protein kinase B akt-2" [UniProt:Q9XTG7]
exact_synonym: "Serine/threonine-protein kinase akt-2" [UniProt:Q9XTG7]
xref_analog: UniProt:Q9XTG7
relationship: sequence_of IMR:0000250 ! Akt

[Term]
id: IMR:0002862
name: SGK1_CAEEL
exact_synonym: "EC 2.7.11.1" [UniProt:Q2PJ68]
exact_synonym: "Serine/threonine-protein kinase sgk-1" [UniProt:Q2PJ68]
exact_synonym: "Serum- and glucocorticoid-inducible kinase homolog" [UniProt:Q2PJ68]
exact_synonym: "Serum/glucocorticoid-regulated kinase 1" [UniProt:Q2PJ68]
exact_synonym: "sgk-1" [UniProt:Q2PJ68]
xref_analog: UniProt:Q2PJ68
relationship: sequence_of IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0002863
name: FOXO_CAEEL
exact_synonym: "Abnormal dauer formation protein 16" [UniProt:O16850]
exact_synonym: "daf-16" [UniProt:O16850]
exact_synonym: "Forkhead box protein O" [UniProt:O16850]
exact_synonym: "FOXO" [UniProt:O16850]
xref_analog: UniProt:O16850
relationship: sequence_of IMR:0002804 ! FOXO

[Term]
id: IMR:0002864
name: TOR_CAEEL
exact_synonym: "CeTOR" [UniProt:Q95Q95]
exact_synonym: "EC 2.7.11.1" [UniProt:Q95Q95]
exact_synonym: "let-363" [UniProt:Q95Q95]
exact_synonym: "Lethal protein 363" [UniProt:Q95Q95]
exact_synonym: "Target of rapamycin homolog" [UniProt:Q95Q95]
exact_synonym: "tor" [UniProt:Q95Q95]
xref_analog: UniProt:Q95Q95
relationship: sequence_of IMR:0002721 ! TOR

[Term]
id: IMR:0002865
name: INSR_CAEEL
def: "DAF-2 is the only member of the insulin receptor family in the C. elegans genome sequence. Because it is equally distant from the human insulin, IGF-I, and insulin receptor-related receptors, DAF-2 is probably the homolog of the ancestor of these duplicated and diverged receptors, and thus may subserve any or all of their functions." [PubMed:9252323]
exact_synonym: "Abnormal dauer formation protein 2" [UniProt:Q968Y9]
exact_synonym: "daf-2" [UniProt:Q968Y9]
exact_synonym: "EC 2.7.10.1" [UniProt:Q968Y9]
exact_synonym: "Insulin-like receptor" [UniProt:Q968Y9]
exact_synonym: "Insulin-like receptor subunit alpha" [UniProt:Q968Y9]
exact_synonym: "Insulin-like receptor subunit beta" [UniProt:Q968Y9]
exact_synonym: "IR" [UniProt:Q968Y9]
xref_analog: UniProt:Q968Y9
relationship: sequence_of IMR:0000075 ! insulin receptor family

[Term]
id: IMR:0002866
name: Q18820_CAEEL
exact_synonym: "Insulin receptor substrate homolog protein 1, confirmed by transcript evidence" [UniProt:Q18820]
exact_synonym: "ist-1" [UniProt:Q18820]
xref_analog: UniProt:Q18820
relationship: sequence_of IMR:0000351 ! IRS

[Term]
id: IMR:0002867
name: O76469_CAEEL
exact_synonym: "ILP1" [UniProt:O76469]
exact_synonym: "ins-1" [UniProt:O76469]
exact_synonym: "Insulin-like peptide" [UniProt:O76469]
exact_synonym: "Protein F13B12.5, confirmed by transcript evidence" [UniProt:O76469]
xref_analog: UniProt:O76469
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002868
name: ILB2_CAEEL
exact_synonym: "ins-2" [UniProt:Q09627]
exact_synonym: "Probable insulin-like peptide beta-type 2" [UniProt:Q09627]
xref_analog: UniProt:Q09627
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002869
name: ILB3_CAEEL
exact_synonym: "ins-3" [UniProt:Q09628]
exact_synonym: "Probable insulin-like peptide beta-type 3" [UniProt:Q09628]
xref_analog: UniProt:Q09628
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002870
name: ILB1_CAEEL
exact_synonym: "ins-4" [UniProt:Q09626]
exact_synonym: "Probable insulin-like peptide beta-type 1" [UniProt:Q09626]
xref_analog: UniProt:Q09626
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002871
name: ILB6_CAEEL
exact_synonym: "ins-5" [UniProt:P56173]
exact_synonym: "Putative insulin-like peptide beta-type 6" [UniProt:P56173]
xref_analog: UniProt:P56173
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002872
name: ILB5_CAEEL
exact_synonym: "ins-6" [UniProt:P56174]
exact_synonym: "Probable insulin-like peptide beta-type 5" [UniProt:P56174]
xref_analog: UniProt:P56174
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002873
name: ILB4_CAEEL
exact_synonym: "ins-7" [UniProt:Q23430]
exact_synonym: "Probable insulin-like peptide beta-type 4" [UniProt:Q23430]
xref_analog: UniProt:Q23430
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002874
name: Q7YTH4_CAEEL
exact_synonym: "ins-8" [UniProt:Q7YTH4]
exact_synonym: "Putative uncharacterized protein ins-8" [UniProt:Q7YTH4]
xref_analog: UniProt:Q7YTH4
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002875
name: Q7JP91_CAEEL
exact_synonym: "ins-9" [UniProt:Q7JP91]
exact_synonym: "Insulin related protein 9" [UniProt:Q7JP91]
xref_analog: UniProt:Q7JP91
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002876
name: Q7YWW0_CAEEL
exact_synonym: "ins-10" [UniProt:Q7YWW0]
exact_synonym: "Protein T08G5.12, confirmed by transcript evidence" [UniProt:Q7YWW0]
xref_analog: UniProt:Q7YWW0
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002877
name: ILG1_CAEEL
exact_synonym: "A-chain-like peptide" [UniProt:Q18060]
exact_synonym: "B-chain-like peptide" [UniProt:Q18060]
exact_synonym: "Ceinsulin-3" [UniProt:Q18060]
exact_synonym: "ins-11" [UniProt:Q18060]
exact_synonym: "Probable insulin-like peptide gamma-type 1" [UniProt:Q18060]
xref_analog: UniProt:Q18060
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002878
name: Q7JP47_CAEEL
exact_synonym: "ins-12" [UniProt:Q7JP47]
exact_synonym: "Putative uncharacterized protein" [UniProt:Q7JP47]
xref_analog: UniProt:Q7JP47
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002879
name: Q7JP48_CAEEL
exact_synonym: "ins-13" [UniProt:Q7JP48]
exact_synonym: "Putative uncharacterized protein" [UniProt:Q7JP48]
xref_analog: UniProt:Q7JP48
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002880
name: Q7JP82_CAEEL
exact_synonym: "ins-14" [UniProt:Q7JP82]
exact_synonym: "Insulin related protein 14, partially confirmed by transcript evidence" [UniProt:Q7JP82]
xref_analog: UniProt:Q7JP82
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002881
name: Q7JP83_CAEEL
exact_synonym: "ins-15" [UniProt:Q7JP83]
exact_synonym: "Insulin related protein 15" [UniProt:Q7JP83]
xref_analog: UniProt:Q7JP83
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002882
name: Q7KX46_CAEEL
exact_synonym: "ins-16" [UniProt:Q7KX46]
exact_synonym: "Insulin related protein 16" [UniProt:Q7KX46]
xref_analog: UniProt:Q7KX46
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002883
name: Q20896_CAEEL
exact_synonym: "Ceinsulin-2" [UniProt:Q20896]
exact_synonym: "ins-17" [UniProt:Q20896]
exact_synonym: "ins-2" [UniProt:Q20896]
exact_synonym: "Protein F56F3.6, confirmed by transcript evidence" [UniProt:Q20896]
xref_analog: UniProt:Q20896
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002884
name: O18149_CAEEL
exact_synonym: "Ceinsulin-1" [UniProt:O18149]
exact_synonym: "ins-1" [UniProt:O18149]
exact_synonym: "ins-18" [UniProt:O18149]
exact_synonym: "Protein T28B8.2, confirmed by transcript evidence" [UniProt:O18149]
xref_analog: UniProt:O18149
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002885
name: Q71UE4_CAEEL
exact_synonym: "ins-19" [UniProt:Q71UE4]
exact_synonym: "Insulin related protein 19" [UniProt:Q71UE4]
xref_analog: UniProt:Q71UE4
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002886
name: Q7JPJ3_CAEEL
exact_synonym: "ins-20" [UniProt:Q7JPJ3]
exact_synonym: "Insulin related protein 20, confirmed by transcript evidence" [UniProt:Q7JPJ3]
xref_analog: UniProt:Q7JPJ3
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002887
name: ILA1_CAEEL
exact_synonym: "ins-21" [UniProt:Q21507]
exact_synonym: "Probable insulin-like peptide alpha-type 1" [UniProt:Q21507]
xref_analog: UniProt:Q21507
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002888
name: ILA2_CAEEL
exact_synonym: "ins-22" [UniProt:Q21508]
exact_synonym: "Probable insulin-like peptide alpha-type 2" [UniProt:Q21508]
xref_analog: UniProt:Q21508
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002889
name: ILA3_CAEEL
exact_synonym: "ins-23" [UniProt:Q21506]
exact_synonym: "Probable insulin-like peptide alpha-type 3" [UniProt:Q21506]
xref_analog: UniProt:Q21506
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002890
name: Q9U1P6_CAEEL
exact_synonym: "ins-24" [UniProt:Q9U1P6]
exact_synonym: "Protein ZC334.3, confirmed by transcript evidence" [UniProt:Q9U1P6]
xref_analog: UniProt:Q9U1P6
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002891
name: Q7JKN0_CAEEL
exact_synonym: "ins-25" [UniProt:Q7JKN0]
exact_synonym: "Putative uncharacterized protein ins-25" [UniProt:Q7JKN0]
xref_analog: UniProt:Q7JKN0
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002892
name: Q9XUI9_CAEEL
exact_synonym: "ins-26" [UniProt:Q9XUI9]
exact_synonym: "Protein ZC334.1, confirmed by transcript evidence" [UniProt:Q9XUI9]
xref_analog: UniProt:Q9XUI9
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002893
name: Q7JKM7_CAEEL
exact_synonym: "ins-27" [UniProt:Q7JKM7]
exact_synonym: "Protein ZC334.11, confirmed by transcript evidence" [UniProt:Q7JKM7]
xref_analog: UniProt:Q7JKM7
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002894
name: Q7JKM9_CAEEL
exact_synonym: "ins-28" [UniProt:Q7JKM9]
exact_synonym: "Protein ZC334.9, confirmed by transcript evidence" [UniProt:Q7JKM9]
xref_analog: UniProt:Q7JKM9
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002895
name: Q7JKM8_CAEEL
exact_synonym: "ins-29" [UniProt:Q7JKM8]
exact_synonym: "Protein ZC334.10, confirmed by transcript evidence" [UniProt:Q7JKM8]
xref_analog: UniProt:Q7JKM8
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002896
name: Q9XUI8_CAEEL
exact_synonym: "ins-30" [UniProt:Q9XUI8]
exact_synonym: "Protein ZC334.2, partially confirmed by transcript evidence" [UniProt:Q9XUI8]
xref_analog: UniProt:Q9XUI8
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002897
name: Q9TZF3_CAEEL
exact_synonym: "ins-31" [UniProt:Q9TZF3]
exact_synonym: "Insulin related protein 31" [UniProt:Q9TZF3]
xref_analog: UniProt:Q9TZF3
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002898
name: Q9TYK2_CAEEL
exact_synonym: "ins-32" [UniProt:Q9TYK2]
exact_synonym: "Insulin related protein 32" [UniProt:Q9TYK2]
xref_analog: UniProt:Q9TYK2
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002899
name: Q9U333_CAEEL
exact_synonym: "ins-33" [UniProt:Q9U333]
exact_synonym: "Protein W09C5.4, confirmed by transcript evidence" [UniProt:Q9U333]
xref_analog: UniProt:Q9U333
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002900
name: Q9XUE8_CAEEL
exact_synonym: "ins-34" [UniProt:Q9XUE8]
exact_synonym: "Protein F52B11.6, confirmed by transcript evidence" [UniProt:Q9XUE8]
xref_analog: UniProt:Q9XUE8
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002901
name: Q9XUV3_CAEEL
exact_synonym: "ins-35" [UniProt:Q9XUV3]
exact_synonym: "Protein K02E2.4, confirmed by transcript evidence" [UniProt:Q9XUV3]
xref_analog: UniProt:Q9XUV3
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002902
name: Q7K6X2_CAEEL
exact_synonym: "ins-36" [UniProt:Q7K6X2]
exact_synonym: "Putative uncharacterized protein ins-36" [UniProt:Q7K6X2]
xref_analog: UniProt:Q7K6X2
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002903
name: Q9XVA1_CAEEL
exact_synonym: "ins-37" [UniProt:Q9XVA1]
exact_synonym: "Protein F08G2.6, confirmed by transcript evidence" [UniProt:Q9XVA1]
xref_analog: UniProt:Q9XVA1
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002904
name: Q7JP45_CAEEL
exact_synonym: "ins-38" [UniProt:Q7JP45]
exact_synonym: "Putative uncharacterized protein" [UniProt:Q7JP45]
xref_analog: UniProt:Q7JP45
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002905
name: O16588_CAEEL
exact_synonym: "ins-39" [UniProt:O16588]
exact_synonym: "Putative uncharacterized protein F21E9.4" [UniProt:O16588]
xref_analog: UniProt:O16588
relationship: sequence_of IMR:0002906 ! INS

[Term]
id: IMR:0002906
name: INS
def: "In the worm, multiple insulin-like peptides (INS) are expressed in many tissues throughout the body and act as receptor agonists or antagonists. The 39 C. elegans insulin-like genes are identified." [PubMed:11274053, PubMed:18226095, PubMed:19159343]
exact_synonym: "insulin-like peptide" []
is_a: IMR:0002835 ! insulin family

[Term]
id: IMR:0002907
name: Q9XTJ1_CAEEL
exact_synonym: "daf-15" [UniProt:Q9XTJ1]
exact_synonym: "Protein C10C5.6b, confirmed by transcript evidence" [UniProt:Q9XTJ1]
xref_analog: UniProt:Q9XTJ1
relationship: sequence_of IMR:0002730 ! Raptor

[Term]
id: IMR:0002908
name: O96525_DROME
exact_synonym: "bdw" [FlyBase:FBgn0004956]
exact_synonym: "bending-wings" [FlyBase:FBgn0004956]
exact_synonym: "CG5993" [FlyBase:FBgn0004956]
exact_synonym: "l(1)YC43" [FlyBase:FBgn0004956]
exact_synonym: "l(1)YM55" [FlyBase:FBgn0004956]
exact_synonym: "od" [FlyBase:FBgn0004956]
exact_synonym: "odsy" [FlyBase:FBgn0004956]
exact_synonym: "os" [UniProt:O96525, FlyBase:FBgn0004956]
exact_synonym: "outstretched" [FlyBase:FBgn0004956]
exact_synonym: "outstretched-smalleye" [FlyBase:FBgn0004956]
exact_synonym: "sis-C" [FlyBase:FBgn0004956]
exact_synonym: "sis-c" [FlyBase:FBgn0004956]
exact_synonym: "sisC" [FlyBase:FBgn0004956]
exact_synonym: "sisterless c" [FlyBase:FBgn0004956]
exact_synonym: "small-eye" [FlyBase:FBgn0004956]
exact_synonym: "sy" [FlyBase:FBgn0004956]
exact_synonym: "unp" [FlyBase:FBgn0004956]
exact_synonym: "unpaired" [UniProt:O96525, FlyBase:FBgn0004956]
exact_synonym: "Unpaired" [FlyBase:FBgn0004956]
exact_synonym: "Unpaired protein" [UniProt:O96525]
exact_synonym: "upa" [FlyBase:FBgn0004956]
exact_synonym: "upd" [FlyBase:FBgn0004956]
exact_synonym: "Upd" [FlyBase:FBgn0004956]
exact_synonym: "UPD" [FlyBase:FBgn0004956]
xref_analog: UniProt:O96525
relationship: sequence_of IMR:0000002 ! ligand

[Term]
id: IMR:0002909
name: DOME_DROME
exact_synonym: "anon-18DEb" [FlyBase:FBgn0043903]
exact_synonym: "CG14226" [FlyBase:FBgn0043903]
exact_synonym: "CT33841" [FlyBase:FBgn0043903]
exact_synonym: "Cytokine receptor" [UniProt:Q9VWE0]
exact_synonym: "dome" [FlyBase:FBgn0043903, UniProt:Q9VWE0]
exact_synonym: "DOME" [FlyBase:FBgn0043903]
exact_synonym: "Dome" [FlyBase:FBgn0043903]
exact_synonym: "domeless" [FlyBase:FBgn0043903]
exact_synonym: "l(1)G0217" [FlyBase:FBgn0043903]
exact_synonym: "l(1)G0218" [FlyBase:FBgn0043903]
exact_synonym: "l(1)G0264" [FlyBase:FBgn0043903]
exact_synonym: "l(1)G0282" [FlyBase:FBgn0043903]
exact_synonym: "l(1)G0321" [FlyBase:FBgn0043903]
exact_synonym: "l(1)G0367" [FlyBase:FBgn0043903]
exact_synonym: "l(1)G0405" [FlyBase:FBgn0043903]
exact_synonym: "l(1)G0441" [FlyBase:FBgn0043903]
exact_synonym: "l(1)G0468" [FlyBase:FBgn0043903]
exact_synonym: "master of marelle" [FlyBase:FBgn0043903]
exact_synonym: "mom" [FlyBase:FBgn0043903]
exact_synonym: "Protein domeless" [UniProt:Q9VWE0]
exact_synonym: "verstopft" [FlyBase:FBgn0043903]
exact_synonym: "vsp" [FlyBase:FBgn0043903]
xref_analog: UniProt:Q9VWE0
relationship: sequence_of IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0002910
name: JAK_DROME
exact_synonym: "4" [FlyBase:FBgn0004864]
exact_synonym: "CG1594" [FlyBase:FBgn0004864]
exact_synonym: "Dm JAK" [FlyBase:FBgn0004864]
exact_synonym: "DmHD-160" [FlyBase:FBgn0004864]
exact_synonym: "EC 2.7.10.2" [UniProt:Q24592]
exact_synonym: "HD-160" [UniProt:Q24592, FlyBase:FBgn0004864]
exact_synonym: "hop" [UniProt:Q24592, FlyBase:FBgn0004864]
exact_synonym: "Hop" [FlyBase:FBgn0004864]
exact_synonym: "Hop1" [FlyBase:FBgn0004864]
exact_synonym: "hopscotch" [FlyBase:FBgn0004864]
exact_synonym: "Hopskotch" [FlyBase:FBgn0004864]
exact_synonym: "JAK" [FlyBase:FBgn0004864]
exact_synonym: "Jak" [FlyBase:FBgn0004864]
exact_synonym: "Jak-STAT" [FlyBase:FBgn0004864]
exact_synonym: "JAK-STAT" [FlyBase:FBgn0004864]
exact_synonym: "Jak/Stat" [FlyBase:FBgn0004864]
exact_synonym: "l(1)10Be" [FlyBase:FBgn0004864]
exact_synonym: "l(1)G18" [FlyBase:FBgn0004864]
exact_synonym: "l(1)hop" [FlyBase:FBgn0004864]
exact_synonym: "l(1)L4" [FlyBase:FBgn0004864]
exact_synonym: "L4" [FlyBase:FBgn0004864]
exact_synonym: "locus 18" [FlyBase:FBgn0004864]
exact_synonym: "msvl" [FlyBase:FBgn0004864]
exact_synonym: "Tum" [FlyBase:FBgn0004864]
exact_synonym: "Tum-1" [FlyBase:FBgn0004864]
exact_synonym: "Tumorous" [FlyBase:FBgn0004864]
exact_synonym: "Tyrosine-protein kinase hopscotch" [UniProt:Q24592]
xref_analog: UniProt:Q24592
relationship: sequence_of IMR:0000213 ! JAK

[Term]
id: IMR:0002911
name: STAT_DROME
def: "Mrl encodes a protein homologous to the mammalian STAT transcription factors. Computer-assisted homology searches in the GenBank and EMBL databases revealed that mrl shares a distinct homology to the human STAT5 and STAT6 proteins. The overall identity between mrl and STAT5 and mrl and STAT6 is 37.0 and 34.7%, respectively." [PubMed:8608595]
exact_synonym: "CG4257" [FlyBase:FBgn0016917]
exact_synonym: "d-STAT" [FlyBase:FBgn0016917, UniProt:Q24151]
exact_synonym: "D-STAT" [FlyBase:FBgn0016917]
exact_synonym: "D-stat" [FlyBase:FBgn0016917]
exact_synonym: "D-Stat" [FlyBase:FBgn0016917]
exact_synonym: "D-stat/stat92E" [FlyBase:FBgn0016917]
exact_synonym: "DmSTAT" [FlyBase:FBgn0016917]
exact_synonym: "DRODSRC" [FlyBase:FBgn0016917]
exact_synonym: "DSRC" [FlyBase:FBgn0016917]
exact_synonym: "DSTAT" [FlyBase:FBgn0016917]
exact_synonym: "dSTAT" [FlyBase:FBgn0016917]
exact_synonym: "Dstat" [FlyBase:FBgn0016917]
exact_synonym: "Dstat 92E" [FlyBase:FBgn0016917]
exact_synonym: "Dstat92E" [FlyBase:FBgn0016917]
exact_synonym: "dSTAT92E/marelle" [FlyBase:FBgn0016917]
exact_synonym: "l(3)06346" [FlyBase:FBgn0016917]
exact_synonym: "l(3)j6C8" [FlyBase:FBgn0016917]
exact_synonym: "MARE" [UniProt:Q24151]
exact_synonym: "marelle" [FlyBase:FBgn0016917]
exact_synonym: "mrL" [FlyBase:FBgn0016917, UniProt:Q24151]
exact_synonym: "mrl" [FlyBase:FBgn0016917]
exact_synonym: "mrl stat92E" [FlyBase:FBgn0016917]
exact_synonym: "Protein marelle" [UniProt:Q24151]
exact_synonym: "SD-stat" [FlyBase:FBgn0016917]
exact_synonym: "Signal transducer and transcription activator" [UniProt:Q24151]
exact_synonym: "Signal-transducer and activator of transcription protein" [FlyBase:FBgn0016917]
exact_synonym: "Signal-transducer and activator of transcription protein at 92E" [FlyBase:FBgn0016917]
exact_synonym: "Stat" [FlyBase:FBgn0016917, UniProt:Q24151]
exact_synonym: "STAT" [FlyBase:FBgn0016917]
exact_synonym: "stat" [FlyBase:FBgn0016917]
exact_synonym: "STAT 92E" [FlyBase:FBgn0016917]
exact_synonym: "Stat1alpha-like" [FlyBase:FBgn0016917]
exact_synonym: "Stat92E" [FlyBase:FBgn0016917, UniProt:Q24151]
exact_synonym: "stat92E" [FlyBase:FBgn0016917]
exact_synonym: "STAT92E" [FlyBase:FBgn0016917]
exact_synonym: "Stat92E/marelle" [FlyBase:FBgn0016917]
xref_analog: UniProt:Q24151
relationship: sequence_of IMR:0000374 ! STAT

[Term]
id: IMR:0002912
name: Q8INY1_DROME
def: "Socs36E encodes a protein with significant homology to the SOCS protein family.  It is a protein with the SH2 and SOCS-box domains being 81% similar (68% identical) to the corresponding regions of human SOCS-5." [PubMed:12101419]
exact_synonym: "anon-EST:Liang-2.2" [FlyBase:FBgn0041184]
exact_synonym: "CG15154" [FlyBase:FBgn0041184]
exact_synonym: "clone 2.2" [FlyBase:FBgn0041184]
exact_synonym: "dmSocs36E" [FlyBase:FBgn0041184]
exact_synonym: "dSOCS" [FlyBase:FBgn0041184]
exact_synonym: "SOCS" [FlyBase:FBgn0041184]
exact_synonym: "Socs" [FlyBase:FBgn0041184]
exact_synonym: "Socs36E" [UniProt:Q8INY1, FlyBase:FBgn0041184]
exact_synonym: "socs36E" [FlyBase:FBgn0041184]
exact_synonym: "SOCS36E" [FlyBase:FBgn0041184]
exact_synonym: "socs60E1" [FlyBase:FBgn0041184]
exact_synonym: "Suppressor of cytokine signaling" [FlyBase:FBgn0041184]
exact_synonym: "Suppressor of cytokine signaling at 36E" [FlyBase:FBgn0041184]
exact_synonym: "Suppressor of cytokine signaling at 36E, isoform B" [UniProt:Q8INY1]
xref_analog: UniProt:Q8INY1
relationship: sequence_of IMR:0000460 ! SOCS

[Term]
id: IMR:0002913
name: SUMO E3 ligase
def: "SUMO E3 ligases are enzymes that catalyse the transfer of SUMO from UBC9 to a substrate." [PubMed:18000527]
is_a: IMR:0010053 ! ligase

[Term]
id: IMR:0002914
name: PIAS
def: "Human PIAS proteins are encoded by four genes, PIAS1, PIASx (PIAS2), PIAS3 and PIASy (PIAS4). PIAS orthologs are found in nonvertebrate animal species. Most of the PIAS functions are by some means linked to SUMO modifications." [PubMed:19526197]
is_a: IMR:0002913 ! SUMO E3 ligase

[Term]
id: IMR:0002915
name: PIAS1
is_a: IMR:0002914 ! PIAS

[Term]
id: IMR:0002916
name: PIAS1_HUMAN
exact_synonym: "DDXBP1" [UniProt:O75925, MIM:603566]
exact_synonym: "DEAD/H box-binding protein 1" [UniProt:O75925, MIM:603566]
exact_synonym: "E3 SUMO-protein ligase PIAS1" [UniProt:O75925]
exact_synonym: "GBP" [HGNC:2752, UniProt:O75925, MIM:603566]
exact_synonym: "Gu-binding protein" [UniProt:O75925, MIM:603566]
exact_synonym: "GU/RH-II" [HGNC:2752]
exact_synonym: "PIAS1" [HGNC:2752, UniProt:O75925, MIM:603566]
exact_synonym: "Protein inhibitor of activated STAT protein 1" [UniProt:O75925]
exact_synonym: "protein inhibitor of activated STAT, 1" [HGNC:2752]
exact_synonym: "PROTEIN INHIBITOR OF ACTIVATED STAT1" [MIM:603566]
exact_synonym: "RNA helicase II-binding protein" [UniProt:O75925]
exact_synonym: "ZMIZ3" [HGNC:2752]
xref_analog: UniProt:O75925
relationship: sequence_of IMR:0002915 ! PIAS1

[Term]
id: IMR:0002917
name: PIAS1_MOUSE
exact_synonym: "Ddxbp1" [MGI:1913125, UniProt:O88907]
exact_synonym: "DEAD/H box-binding protein 1" [UniProt:O88907]
exact_synonym: "E3 SUMO-protein ligase PIAS1" [UniProt:O88907]
exact_synonym: "GBP" [MGI:1913125]
exact_synonym: "Pias1" [MGI:1913125, UniProt:O88907]
exact_synonym: "protein inhibitor of activated STAT 1" [MGI:1913125]
exact_synonym: "Protein inhibitor of activated STAT protein 1" [UniProt:O88907]
xref_analog: UniProt:O88907
relationship: sequence_of IMR:0002915 ! PIAS1

[Term]
id: IMR:0002918
name: PIAS2
exact_synonym: "PIASx" []
is_a: IMR:0002914 ! PIAS

[Term]
id: IMR:0002919
name: PIAS2_HUMAN
exact_synonym: "Androgen receptor-interacting protein 3" [UniProt:O75928]
exact_synonym: "ARIP3" [UniProt:O75928]
exact_synonym: "DAB2-interacting protein" [UniProt:O75928]
exact_synonym: "DIP" [UniProt:O75928]
exact_synonym: "E3 SUMO-protein ligase PIAS2" [UniProt:O75928]
exact_synonym: "MGC102682" [EntrezGene:9063]
exact_synonym: "miz" [EntrezGene:9063, HGNC:17311]
exact_synonym: "Miz1" [UniProt:O75928, MIM:603567]
exact_synonym: "MIZ1" [EntrezGene:9063]
exact_synonym: "Msx-interacting zinc finger protein" [UniProt:O75928]
exact_synonym: "PIAS-NY protein" [UniProt:O75928]
exact_synonym: "PIAS2" [UniProt:O75928, EntrezGene:9063, HGNC:17311, MIM:603567]
exact_synonym: "PIASX" [UniProt:O75928, EntrezGene:9063, MIM:603567]
exact_synonym: "PIASX-ALPHA" [EntrezGene:9063, HGNC:17311]
exact_synonym: "PIASX-BETA" [EntrezGene:9063, HGNC:17311]
exact_synonym: "Protein inhibitor of activated STAT x" [UniProt:O75928, MIM:603567]
exact_synonym: "protein inhibitor of activated STAT, 2" [EntrezGene:9063, HGNC:17311]
exact_synonym: "Protein inhibitor of activated STAT2" [UniProt:O75928, MIM:603567]
exact_synonym: "SIZ2" [EntrezGene:9063]
exact_synonym: "ZMIZ4" [EntrezGene:9063, HGNC:17311]
xref_analog: UniProt:O75928
relationship: sequence_of IMR:0002918 ! PIAS2

[Term]
id: IMR:0002920
name: PIAS2_MOUSE
exact_synonym: "Androgen receptor-interacting protein 3" [UniProt:Q8C5D8]
exact_synonym: "ARIP3" [MGI:1096566, UniProt:Q8C5D8]
exact_synonym: "DAB2-interacting protein" [UniProt:Q8C5D8]
exact_synonym: "Dib" [MGI:1096566]
exact_synonym: "DIP" [UniProt:Q8C5D8]
exact_synonym: "E3 SUMO-protein ligase PIAS2" [UniProt:Q8C5D8]
exact_synonym: "Miz1" [MGI:1096566, UniProt:Q8C5D8]
exact_synonym: "Msx-interacting zinc finger protein" [UniProt:Q8C5D8]
exact_synonym: "Pias2" [MGI:1096566, UniProt:Q8C5D8]
exact_synonym: "Piasx" [UniProt:Q8C5D8]
exact_synonym: "PIASxalpha" [MGI:1096566]
exact_synonym: "PIASxb" [MGI:1096566]
exact_synonym: "PIASxbeta" [MGI:1096566]
exact_synonym: "protein inhibitor of activated STAT 2" [MGI:1096566]
exact_synonym: "Protein inhibitor of activated STAT x" [UniProt:Q8C5D8]
exact_synonym: "Protein inhibitor of activated STAT2" [UniProt:Q8C5D8]
xref_analog: UniProt:Q8C5D8
relationship: sequence_of IMR:0002918 ! PIAS2

[Term]
id: IMR:0002921
name: PIAS2_RAT
exact_synonym: "Androgen receptor-interacting protein 3" [UniProt:Q6AZ28]
exact_synonym: "ARIP3" [UniProt:Q6AZ28]
exact_synonym: "DAB2-interacting protein" [UniProt:Q6AZ28]
exact_synonym: "DIP" [UniProt:Q6AZ28]
exact_synonym: "E3 SUMO-protein ligase PIAS2" [UniProt:Q6AZ28]
exact_synonym: "Miz1" [UniProt:Q6AZ28]
exact_synonym: "Msx-interacting-zinc finger protein" [UniProt:Q6AZ28]
exact_synonym: "Pias2" [RGD:71056, UniProt:Q6AZ28]
exact_synonym: "Piasx" [UniProt:Q6AZ28]
exact_synonym: "Protein inhibitor of activated STAT x" [UniProt:Q6AZ28]
exact_synonym: "protein inhibitor of activated STAT, 2" [RGD:71056]
exact_synonym: "Protein inhibitor of activated STAT2" [UniProt:Q6AZ28]
xref_analog: UniProt:Q6AZ28
relationship: sequence_of IMR:0002918 ! PIAS2

[Term]
id: IMR:0002922
name: PIAS3
is_a: IMR:0002914 ! PIAS

[Term]
id: IMR:0002923
name: PIAS3_HUMAN
exact_synonym: "E3 SUMO-protein ligase PIAS3" [UniProt:Q9Y6X2]
exact_synonym: "FLJ14651" [HGNC:16861, EntrezGene:10401]
exact_synonym: "PIAS3" [HGNC:16861, UniProt:Q9Y6X2, MIM:605987, EntrezGene:10401]
exact_synonym: "Protein inhibitor of activated STAT protein 3" [UniProt:Q9Y6X2]
exact_synonym: "protein inhibitor of activated STAT, 3" [HGNC:16861, EntrezGene:10401]
exact_synonym: "PROTEIN INHIBITOR OF ACTIVATED STAT3" [MIM:605987]
exact_synonym: "ZMIZ5" [HGNC:16861, EntrezGene:10401]
xref_analog: UniProt:Q9Y6X2
relationship: sequence_of IMR:0002922 ! PIAS3

[Term]
id: IMR:0002924
name: PIAS3_MOUSE
exact_synonym: "E3 SUMO-protein ligase PIAS3" [UniProt:O54714]
exact_synonym: "Pias3" [UniProt:O54714, MGI:1913126]
exact_synonym: "Pias3L" [MGI:1913126]
exact_synonym: "protein inhibitor of activated STAT 3" [MGI:1913126]
exact_synonym: "Protein inhibitor of activated STAT protein 3" [UniProt:O54714]
xref_analog: UniProt:O54714
relationship: sequence_of IMR:0002922 ! PIAS3

[Term]
id: IMR:0002925
name: PIAS3_RAT
exact_synonym: "E3 SUMO-protein ligase PIAS3" [UniProt:O70260]
exact_synonym: "KChAP" [UniProt:O70260]
exact_synonym: "Pias3" [RGD:708413, UniProt:O70260]
exact_synonym: "Potassium channel-associated protein" [UniProt:O70260]
exact_synonym: "Protein inhibitor of activated STAT protein 3" [UniProt:O70260]
exact_synonym: "protein inhibitor of activated STAT, 3" [RGD:708413]
xref_analog: UniProt:O70260
relationship: sequence_of IMR:0002922 ! PIAS3

[Term]
id: IMR:0002926
name: PIAS4
exact_synonym: "PIASy" []
is_a: IMR:0002914 ! PIAS

[Term]
id: IMR:0002927
name: PIAS4_HUMAN
exact_synonym: "E3 SUMO-protein ligase PIAS4" [UniProt:Q8N2W9]
exact_synonym: "FLJ12419" [HGNC:17002, EntrezGene:51588]
exact_synonym: "MGC35296" [EntrezGene:51588]
exact_synonym: "PIAS-gamma" [UniProt:Q8N2W9]
exact_synonym: "PIAS4" [HGNC:17002, UniProt:Q8N2W9, EntrezGene:51588, MIM:605989]
exact_synonym: "PIASG" [UniProt:Q8N2W9]
exact_synonym: "Piasg" [HGNC:17002, EntrezGene:51588]
exact_synonym: "PIASy" [UniProt:Q8N2W9, MIM:605989]
exact_synonym: "PIASY" [HGNC:17002, EntrezGene:51588]
exact_synonym: "Protein inhibitor of activated STAT protein 4" [UniProt:Q8N2W9]
exact_synonym: "Protein inhibitor of activated STAT protein gamma" [UniProt:Q8N2W9]
exact_synonym: "PROTEIN INHIBITOR OF ACTIVATED STAT Y" [MIM:605989]
exact_synonym: "protein inhibitor of activated STAT, 4" [HGNC:17002, EntrezGene:51588]
exact_synonym: "PROTEIN INHIBITOR OF ACTIVATED STAT4" [MIM:605989]
exact_synonym: "ZMIZ6" [HGNC:17002, EntrezGene:51588]
xref_analog: UniProt:Q8N2W9
relationship: sequence_of IMR:0002926 ! PIAS4

[Term]
id: IMR:0002928
name: PIAS4_MOUSE
exact_synonym: "E3 SUMO-protein ligase PIAS4" [UniProt:Q9JM05]
exact_synonym: "PIAS-gamma" [UniProt:Q9JM05]
exact_synonym: "Pias4" [UniProt:Q9JM05, MGI:2136940]
exact_synonym: "Piasg" [UniProt:Q9JM05]
exact_synonym: "PIASy" [UniProt:Q9JM05, MGI:2136940]
exact_synonym: "protein inhibitor of activated STAT 4" [MGI:2136940]
exact_synonym: "Protein inhibitor of activated STAT protein 4" [UniProt:Q9JM05]
exact_synonym: "Protein inhibitor of activated STAT protein gamma" [UniProt:Q9JM05]
xref_analog: UniProt:Q9JM05
relationship: sequence_of IMR:0002926 ! PIAS4

[Term]
id: IMR:0002929
name: Q7KNF5_DROME
exact_synonym: "CG8068" [FlyBase:FBgn0003612]
exact_synonym: "CLOT2057" [FlyBase:FBgn0003612]
exact_synonym: "dPIAS" [FlyBase:FBgn0003612]
exact_synonym: "Dpias" [FlyBase:FBgn0003612]
exact_synonym: "dpias" [FlyBase:FBgn0003612]
exact_synonym: "DPIAS" [FlyBase:FBgn0003612]
exact_synonym: "i184" [FlyBase:FBgn0003612]
exact_synonym: "l(2)03697" [FlyBase:FBgn0003612]
exact_synonym: "PIAS" [FlyBase:FBgn0003612]
exact_synonym: "Su(var)2-10" [FlyBase:FBgn0003612, UniProt:Q7KNF5]
exact_synonym: "Su(Var)2-10" [FlyBase:FBgn0003612]
exact_synonym: "Su-var(2)10" [FlyBase:FBgn0003612]
exact_synonym: "Suppressor of variegation 2-10" [FlyBase:FBgn0003612]
exact_synonym: "Suppressor of variegation 2-10, isoform A" [UniProt:Q7KNF5]
exact_synonym: "Suvar(2)10" [FlyBase:FBgn0003612]
exact_synonym: "zimp" [FlyBase:FBgn0003612, UniProt:Q7KNF5]
exact_synonym: "Zimp-A" [UniProt:Q7KNF5]
exact_synonym: "ZimpA" [FlyBase:FBgn0003612]
exact_synonym: "ZimpB" [FlyBase:FBgn0003612]
exact_synonym: "zinc finger-containing Miz1 PIAS3-like" [FlyBase:FBgn0003612]
xref_analog: UniProt:Q7KNF5
relationship: sequence_of IMR:0002914 ! PIAS

[Term]
id: IMR:0002930
name: KEN_DROME
def: "Ken & Barbie (Ken) is an ortholog of the mammalian proto-oncogene BCL6." [PubMed:16401426, PubMed:16461274]
exact_synonym: "2970" [FlyBase:FBgn0011236]
exact_synonym: "3907" [FlyBase:FBgn0011236]
exact_synonym: "5029" [FlyBase:FBgn0011236]
exact_synonym: "8253" [FlyBase:FBgn0011236]
exact_synonym: "CG5575" [FlyBase:FBgn0011236]
exact_synonym: "ken" [FlyBase:FBgn0011236, UniProt:O77459]
exact_synonym: "ken & barbie" [FlyBase:FBgn0011236]
exact_synonym: "ken and barbie" [FlyBase:FBgn0011236]
exact_synonym: "l(2)00628" [FlyBase:FBgn0011236]
exact_synonym: "l(2)02970" [FlyBase:FBgn0011236]
exact_synonym: "l(2)05029" [FlyBase:FBgn0011236]
exact_synonym: "ok" [FlyBase:FBgn0011236]
exact_synonym: "okina" [FlyBase:FBgn0011236]
exact_synonym: "P420" [FlyBase:FBgn0011236]
exact_synonym: "Protein Ken and Barbie" [UniProt:O77459]
exact_synonym: "Transcription factor Ken" [UniProt:O77459]
xref_analog: UniProt:O77459
relationship: sequence_of IMR:0000417 ! BCL-6

[Term]
id: IMR:0002931
name: BCL6_MOUSE
exact_synonym: "B-cell leukemia/lymphoma 6" [MGI:107187]
exact_synonym: "B-cell lymphoma 6 protein homolog" [UniProt:P41183]
exact_synonym: "Bcl-6" [UniProt:P41183]
exact_synonym: "Bcl5" [MGI:107187]
exact_synonym: "Bcl6" [UniProt:P41183, MGI:107187]
xref_analog: UniProt:P41183
relationship: sequence_of IMR:0000417 ! BCL-6

[Term]
id: IMR:0002932
name: CF1A_DROME
exact_synonym: "CF1-A" [UniProt:P16241]
exact_synonym: "Cf1-a" [FlyBase:FBgn0086680]
exact_synonym: "Cf1a" [FlyBase:FBgn0086680, UniProt:P16241]
exact_synonym: "Cf1a/drifter" [FlyBase:FBgn0086680]
exact_synonym: "Cfla" [FlyBase:FBgn0086680]
exact_synonym: "CG10037" [FlyBase:FBgn0086680]
exact_synonym: "Chorion factor 1A" [UniProt:P16241]
exact_synonym: "dfr" [FlyBase:FBgn0086680]
exact_synonym: "DFR" [FlyBase:FBgn0086680]
exact_synonym: "dfr-vvl" [FlyBase:FBgn0086680]
exact_synonym: "Dfr/Vvl" [FlyBase:FBgn0086680]
exact_synonym: "dfr/vvl" [FlyBase:FBgn0086680]
exact_synonym: "drf" [FlyBase:FBgn0086680]
exact_synonym: "drifter" [FlyBase:FBgn0086680]
exact_synonym: "Drifter" [FlyBase:FBgn0086680]
exact_synonym: "Drifter/Ventral veinless" [FlyBase:FBgn0086680]
exact_synonym: "paired-like 3" [FlyBase:FBgn0086680]
exact_synonym: "POU domain protein CF1A" [UniProt:P16241]
exact_synonym: "PRD gene 3" [FlyBase:FBgn0086680]
exact_synonym: "prd3" [FlyBase:FBgn0086680]
exact_synonym: "Protein drifter" [UniProt:P16241]
exact_synonym: "u-turn" [FlyBase:FBgn0086680]
exact_synonym: "U-turn" [FlyBase:FBgn0086680]
exact_synonym: "ut" [FlyBase:FBgn0086680]
exact_synonym: "ventral veins lacking" [FlyBase:FBgn0086680]
exact_synonym: "Ventral veins lacking protein" [UniProt:P16241]
exact_synonym: "Vv1" [FlyBase:FBgn0086680]
exact_synonym: "vvl" [FlyBase:FBgn0086680, UniProt:P16241]
exact_synonym: "VVL" [FlyBase:FBgn0086680]
xref_analog: UniProt:P16241
relationship: sequence_of IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0002933
name: Ihog/Boi/Cdo/Boc
def: "The Ihog family includes two Drosophila proteins, Ihog and Boi, and two vertebrate proteins, CDO and BOC. The Ihog family plays a conserved function in Hh signaling across species." [PubMed:16630821, PubMed:18355756]
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0002934
name: Ihog/Boi
is_a: IMR:0002933 ! Ihog/Boi/Cdo/Boc

[Term]
id: IMR:0002935
name: Cdo/Boc
is_a: IMR:0002933 ! Ihog/Boi/Cdo/Boc

[Term]
id: IMR:0002936
name: IHOG_DROME
exact_synonym: "iHog" [UniProt:Q9VM64]
exact_synonym: "ihog" [FlyBase:FBgn0031872]
exact_synonym: "Interference hedgehog" [UniProt:Q9VM64]
exact_synonym: "interference hedgehog" [FlyBase:FBgn0031872]
xref_analog: UniProt:Q9VM64
relationship: sequence_of IMR:0002934 ! Ihog/Boi

[Term]
id: IMR:0002937
name: Q9W4Y6_DROME
exact_synonym: "boi" [UniProt:Q9W4Y6, FlyBase:FBgn0040388]
exact_synonym: "boi-RB" [UniProt:Q9W4Y6]
exact_synonym: "brother of ihog" [FlyBase:FBgn0040388]
exact_synonym: "Brother of iHog, isoform B" [UniProt:Q9W4Y6]
exact_synonym: "FI05294p" [UniProt:Q9W4Y6]
xref_analog: UniProt:Q9W4Y6
relationship: sequence_of IMR:0002934 ! Ihog/Boi

[Term]
id: IMR:0002938
name: Cdo
is_a: IMR:0002935 ! Cdo/Boc

[Term]
id: IMR:0002939
name: Boc
is_a: IMR:0002935 ! Cdo/Boc

[Term]
id: IMR:0002940
name: CDON_HUMAN
exact_synonym: "CDO" [HGNC:17104, EntrezGene:50937, MIM:608707, UniProt:Q4KMG0]
exact_synonym: "CDON" [HGNC:17104, EntrezGene:50937, MIM:608707, UniProt:Q4KMG0]
exact_synonym: "Cdon homolog (mouse)" [HGNC:17104, EntrezGene:50937]
exact_synonym: "Cell adhesion molecule-related/down-regulated by oncogenes" [UniProt:Q4KMG0]
exact_synonym: "CELL ADHESION MOLECULE-RELATED/DOWNREGULATED BY ONCOGENES" [MIM:608707]
exact_synonym: "MGC111524" [EntrezGene:50937]
exact_synonym: "ORCAM" [HGNC:17104, EntrezGene:50937]
xref_analog: UniProt:Q4KMG0
relationship: sequence_of IMR:0002938 ! Cdo

[Term]
id: IMR:0002941
name: CDON_MOUSE
exact_synonym: "CAM-related/down-regulated by oncogenes" [MGI:1926387]
exact_synonym: "Cdo" [UniProt:Q32MD9]
exact_synonym: "CDO" [MGI:1926387]
exact_synonym: "Cdon" [MGI:1926387, UniProt:Q32MD9]
exact_synonym: "Cell adhesion molecule-related/down-regulated by oncogenes" [UniProt:Q32MD9]
exact_synonym: "cell adhesion molecule-related/down-regulated by oncogenes" [MGI:1926387]
xref_analog: UniProt:Q32MD9
relationship: sequence_of IMR:0002938 ! Cdo

[Term]
id: IMR:0002942
name: CDON_RAT
exact_synonym: "Cdo" [UniProt:O35158]
exact_synonym: "Cdon" [RGD:708433, UniProt:O35158]
exact_synonym: "Cdon homolog (mouse)" [RGD:708433]
exact_synonym: "Cell adhesion molecule-related/down-regulated by oncogenes" [UniProt:O35158]
xref_analog: UniProt:O35158
relationship: sequence_of IMR:0002938 ! Cdo

[Term]
id: IMR:0002943
name: BOC_HUMAN
exact_synonym: "BOC" [UniProt:Q9BWV1, HGNC:17173, EntrezGene:91653, MIM:608708]
exact_synonym: "Boc homolog (mouse)" [HGNC:17173, EntrezGene:91653]
exact_synonym: "Brother of CDO" [UniProt:Q9BWV1, MIM:608708]
exact_synonym: "BROTHER OF CDON" [MIM:608708]
exact_synonym: "Protein BOC" [UniProt:Q9BWV1]
xref_analog: UniProt:Q9BWV1
relationship: sequence_of IMR:0002939 ! Boc

[Term]
id: IMR:0002944
name: BOC_MOUSE
exact_synonym: "biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein" [MGI:2151153]
exact_synonym: "Boc" [MGI:2151153, UniProt:Q6AZB0]
exact_synonym: "Brother of CDO" [UniProt:Q6AZB0]
exact_synonym: "Protein BOC" [UniProt:Q6AZB0]
xref_analog: UniProt:Q6AZB0
relationship: sequence_of IMR:0002939 ! Boc

[Term]
id: IMR:0002945
name: Hip
def: "Hip encodes a membrane glycoprotein that binds to all three mammalian Hedgehog proteins with an affinity comparable to that of Ptc-1. Hip attenuates Hedgehog signalling as a result of binding to Hedgehog proteins." [PubMed:10050855]
exact_synonym: "Hedgehog-interacting protein" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0002946
name: HHIP_HUMAN
exact_synonym: "FLJ20992" [EntrezGene:64399, HGNC:14866]
exact_synonym: "FLJ90230" [EntrezGene:64399]
exact_synonym: "hedgehog interacting protein" [EntrezGene:64399, HGNC:14866]
exact_synonym: "Hedgehog-interacting protein" [MIM:606178, UniProt:Q96QV1]
exact_synonym: "HHIP" [EntrezGene:64399, MIM:606178, UniProt:Q96QV1, HGNC:14866]
exact_synonym: "HIP" [EntrezGene:64399, MIM:606178, UniProt:Q96QV1, HGNC:14866]
xref_analog: UniProt:Q96QV1
relationship: sequence_of IMR:0002945 ! Hip

[Term]
id: IMR:0002947
name: HHIP_MOUSE
exact_synonym: "Hedgehog-interacting protein" [MGI:1341847, UniProt:Q7TN16]
exact_synonym: "HHIP" [UniProt:Q7TN16]
exact_synonym: "Hhip" [MGI:1341847, UniProt:Q7TN16]
exact_synonym: "Hhip1" [MGI:1341847]
exact_synonym: "HIP" [UniProt:Q7TN16]
exact_synonym: "Hip" [MGI:1341847, UniProt:Q7TN16]
exact_synonym: "Hip1" [MGI:1341847]
xref_analog: UniProt:Q7TN16
relationship: sequence_of IMR:0002945 ! Hip

[Term]
id: IMR:0002948
name: mIgM/mIgD
def: "In mature B cells, the antigen receptor normally consists of two isotypes, membrane IgM and IgD (mIgM, mIgD)." [PubMed:16895553]
exact_synonym: "membrane IgM/membrane IgD" []
relationship: part_of IMR:0000153 ! BCR

[Term]
id: IMR:0002949
name: mu heavy chain/delta heavy chain
relationship: part_of IMR:0002948 ! mIgM/mIgD

[Term]
id: IMR:0002950
name: CD80/CD86
def: "B7.1 (CD80) and B7.2 (CD86) - the two structurally homologous ligands of CD28 - are expressed by professional antigen-presenting cells (APCs), such as dendritic cells (DCs), macrophages and activated B cells, belong to the immunoglobulin superfamily and might exist as dimers and monomers, respectively." [PubMed:14647476]
exact_synonym: "B7.1/B7.2" []
is_a: IMR:0000002 ! ligand

[Term]
id: IMR:0002951
name: Arrow/LRP5/LRP6
def: "Arrow/Lrp5/Lrp6 is a subfamily of the LDL receptor (LDLR) family. Arrow, and also its counterparts LRP5 and LRP6 in mammals and in frogs, appears to function as a coreceptor for Wnt together with the seven-transmembrane receptor Frizzled (frz) in forming the Wnt receptor signaling complex." [PubMed:12045102, PubMed:15084453]
is_a: IMR:0000974 ! LDL receptor family

[Term]
id: IMR:0002952
name: Q8AYF1_XENLA
exact_synonym: "Lipoprotein receptor-related protein 5" [UniProt:Q8AYF1]
exact_synonym: "lrp5" [UniProt:Q8AYF1]
xref_analog: UniProt:Q8AYF1
relationship: sequence_of IMR:0000964 ! LRP5

[Term]
id: IMR:0002953
name: Q8AYF0_XENLA
exact_synonym: "Lipoprotein receptor-related protein 6" [UniProt:Q8AYF0]
exact_synonym: "lrp6" [UniProt:Q8AYF0]
xref_analog: UniProt:Q8AYF0
relationship: sequence_of IMR:0000970 ! LRP6

[Term]
id: IMR:0002954
name: LRP5/LRP6
def: "Lrp5 and Lrp6 are highly homologous, and are widely co-expressed during embryogenesis and in adult tissues. An orthologue in Drosophila melanogaster is known as arrow, a gene that functions in the canonical Wnt signaling pathway." [PubMed:12045102, PubMed:15084453]
is_a: IMR:0002951 ! Arrow/LRP5/LRP6

[Term]
id: IMR:0002955
name: GRK2
is_a: IMR:0000254 ! G-protein coupled receptor kinase

[Term]
id: IMR:0002956
name: beta-arrestin 1
is_a: IMR:0000520 ! arrestin

[Term]
id: IMR:0002957
name: beta-arrestin 2
is_a: IMR:0000520 ! arrestin

[Term]
id: IMR:0002958
name: Dlp/Dally
is_a: IMR:0001139 ! glypican

[Term]
id: IMR:0002959
name: rhomboid
def: "Rhomboids are found in almost all species. Drosophila Rhomboid-1 was discovered to be the first known intramembrane serine protease." [PubMed:11672525, PubMed:12620104, PubMed:17938163, PubMed:19022390]
is_a: IMR:0000304 ! protease

[Term]
id: IMR:0002960
name: RHOM_DROME
exact_synonym: "CG1004" [FlyBase:FBgn0004635]
exact_synonym: "DMRHO" [FlyBase:FBgn0004635]
exact_synonym: "DMRHOa" [FlyBase:FBgn0004635]
exact_synonym: "DMRHOb" [FlyBase:FBgn0004635]
exact_synonym: "DRORHO" [FlyBase:FBgn0004635]
exact_synonym: "EC 3.4.21.105" [UniProt:P20350]
exact_synonym: "Protein rhomboid" [UniProt:P20350]
exact_synonym: "Protein veinlet" [UniProt:P20350]
exact_synonym: "rho" [FlyBase:FBgn0004635, UniProt:P20350]
exact_synonym: "Rho" [FlyBase:FBgn0004635]
exact_synonym: "RHO" [FlyBase:FBgn0004635]
exact_synonym: "Rho-1" [FlyBase:FBgn0004635]
exact_synonym: "rho-1" [FlyBase:FBgn0004635]
exact_synonym: "Rho1" [FlyBase:FBgn0004635]
exact_synonym: "rho1" [FlyBase:FBgn0004635]
exact_synonym: "RHOb" [FlyBase:FBgn0004635]
exact_synonym: "rhom" [FlyBase:FBgn0004635]
exact_synonym: "Rhomboid" [FlyBase:FBgn0004635]
exact_synonym: "rhomboid" [FlyBase:FBgn0004635]
exact_synonym: "Rhomboid 1" [FlyBase:FBgn0004635]
exact_synonym: "Rhomboid-1" [FlyBase:FBgn0004635]
exact_synonym: "rhomboid-1" [FlyBase:FBgn0004635]
exact_synonym: "rhomboid/veinlet" [FlyBase:FBgn0004635]
exact_synonym: "rhomboid1" [FlyBase:FBgn0004635]
exact_synonym: "Ve" [FlyBase:FBgn0004635, UniProt:P20350]
exact_synonym: "ve" [FlyBase:FBgn0004635]
exact_synonym: "Veinlet" [FlyBase:FBgn0004635]
exact_synonym: "veinlet" [FlyBase:FBgn0004635]
xref_analog: UniProt:P20350
relationship: sequence_of IMR:0002959 ! rhomboid

[Term]
id: IMR:0002961
name: RHBL1_HUMAN
exact_synonym: "DROSOPHILA RHOMBOID-LIKE" [MIM:603264]
exact_synonym: "EC 3.4.21.105" [UniProt:O75783]
exact_synonym: "RHBDL" [UniProt:O75783, EntrezGene:9028, MIM:603264]
exact_synonym: "RHBDL1" [UniProt:O75783, EntrezGene:9028, HGNC:10007, MIM:603264]
exact_synonym: "rhomboid, veinlet-like 1 (Drosophila)" [EntrezGene:9028, HGNC:10007]
exact_synonym: "RHOMBOID-LIKE 1" [MIM:603264]
exact_synonym: "Rhomboid-like protein 1" [UniProt:O75783]
exact_synonym: "RHOMBOID-RELATED PROTEIN" [MIM:603264]
exact_synonym: "Rhomboid-related protein 1" [UniProt:O75783]
exact_synonym: "RRP" [UniProt:O75783, EntrezGene:9028, HGNC:10007, MIM:603264]
xref_analog: UniProt:O75783
relationship: sequence_of IMR:0002959 ! rhomboid

[Term]
id: IMR:0002962
name: RHBL2_HUMAN
exact_synonym: "EC 3.4.21.105" [UniProt:Q9NX52]
exact_synonym: "FLJ20435" [HGNC:16083]
exact_synonym: "MGC16997" [EntrezGene:54933]
exact_synonym: "RHBDL2" [EntrezGene:54933, HGNC:16083, UniProt:Q9NX52, MIM:608962]
exact_synonym: "rhomboid, veinlet-like 2 (Drosophila)" [EntrezGene:54933, HGNC:16083]
exact_synonym: "RHOMBOID-LIKE 2" [MIM:608962]
exact_synonym: "Rhomboid-like protein 2" [UniProt:Q9NX52]
exact_synonym: "Rhomboid-related protein 2" [UniProt:Q9NX52]
exact_synonym: "RRP2" [EntrezGene:54933, UniProt:Q9NX52]
xref_analog: UniProt:Q9NX52
relationship: sequence_of IMR:0002959 ! rhomboid

[Term]
id: IMR:0002963
name: RHBL1_MOUSE
exact_synonym: "EC 3.4.21.105" [UniProt:Q8VC82]
exact_synonym: "Rhbdl" [MGI:2384891, UniProt:Q8VC82]
exact_synonym: "Rhbdl1" [MGI:2384891, UniProt:Q8VC82]
exact_synonym: "rhomboid, veinlet-like 1 (Drosophila)" [MGI:2384891]
exact_synonym: "Rhomboid-like protein 1" [UniProt:Q8VC82]
exact_synonym: "Rhomboid-related protein 1" [UniProt:Q8VC82]
exact_synonym: "RRP" [UniProt:Q8VC82]
xref_analog: UniProt:Q8VC82
relationship: sequence_of IMR:0002959 ! rhomboid

[Term]
id: IMR:0002964
name: RHBL3_MOUSE
exact_synonym: "EC 3.4.21.105" [UniProt:P58873]
exact_synonym: "Rhbdl3" [UniProt:P58873, MGI:2179276]
exact_synonym: "Rhbdl4" [UniProt:P58873, MGI:2179276]
exact_synonym: "rhomboid, veinlet-like 3 (Drosophila)" [MGI:2179276]
exact_synonym: "Rhomboid-related protein 3" [UniProt:P58873]
exact_synonym: "Ventrhoid" [MGI:2179276]
exact_synonym: "Ventrhoid transmembrane protein" [UniProt:P58873]
exact_synonym: "Vrho" [UniProt:P58873, MGI:2179276]
xref_analog: UniProt:P58873
relationship: sequence_of IMR:0002959 ! rhomboid

[Term]
id: IMR:0002965
name: STAR_DROME
def: "Star regulates EGF receptor signaling by moving Spitz, which is normally retained in the ER, into the Golgi apparatus where it encounters the proteolytic action promoted by Rhomboid-1." [PubMed:11672524, PubMed:17092823]
exact_synonym: "CG4385" [FlyBase:FBgn0003310]
exact_synonym: "E(Raf)2B" [FlyBase:FBgn0003310]
exact_synonym: "EK2-2" [FlyBase:FBgn0003310]
exact_synonym: "Enhancer of GMR-sina 2-4" [FlyBase:FBgn0003310]
exact_synonym: "ES2-4" [FlyBase:FBgn0003310]
exact_synonym: "EY2-4" [FlyBase:FBgn0003310]
exact_synonym: "floater" [FlyBase:FBgn0003310]
exact_synonym: "fltr" [FlyBase:FBgn0003310]
exact_synonym: "l(2)05671" [FlyBase:FBgn0003310]
exact_synonym: "l(2)07056" [FlyBase:FBgn0003310]
exact_synonym: "l(2)21Eb" [FlyBase:FBgn0003310]
exact_synonym: "l(2)c00080" [FlyBase:FBgn0003310]
exact_synonym: "l(2)k09538" [FlyBase:FBgn0003310]
exact_synonym: "l(2)rK134" [FlyBase:FBgn0003310]
exact_synonym: "lethal (2) c00080" [FlyBase:FBgn0003310]
exact_synonym: "Protein Star" [UniProt:P42519]
exact_synonym: "S" [UniProt:P42519, FlyBase:FBgn0003310]
exact_synonym: "star" [FlyBase:FBgn0003310]
exact_synonym: "Star" [FlyBase:FBgn0003310]
exact_synonym: "Star/asteroid" [FlyBase:FBgn0003310]
xref_analog: UniProt:P42519
relationship: sequence_of IMR:0000428 ! signal regulator

[Term]
id: IMR:0002966
name: SPITZ_DROME
def: "Drosophila Spitz is a homolog of transforming growth factor a (TGF-a) and is an activating ligand for the EGF receptor (Egfr)." [PubMed:11520660, PubMed:1644292, PubMed:17092823]
exact_synonym: "anon-WO0118547.158" [FlyBase:FBgn0005672]
exact_synonym: "CG10334" [FlyBase:FBgn0005672]
exact_synonym: "CT29014" [FlyBase:FBgn0005672]
exact_synonym: "EP(2)2378" [FlyBase:FBgn0005672]
exact_synonym: "l(2)01068" [FlyBase:FBgn0005672]
exact_synonym: "l(2)37Fa" [FlyBase:FBgn0005672]
exact_synonym: "l(2)s3547" [FlyBase:FBgn0005672]
exact_synonym: "Protein spitz" [UniProt:Q01083]
exact_synonym: "spi" [FlyBase:FBgn0005672, UniProt:Q01083]
exact_synonym: "Spi" [FlyBase:FBgn0005672]
exact_synonym: "Spitz" [FlyBase:FBgn0005672]
exact_synonym: "spitz" [FlyBase:FBgn0005672]
xref_analog: UniProt:Q01083
relationship: sequence_of IMR:0100278 ! TGF-alpha

[Term]
id: IMR:0002967
name: GIL_DROME
def: "Argos inhibits epidermal growth factor receptor signalling by ligand sequestration." [PubMed:15329724, PubMed:17092823]
exact_synonym: "Aos" [FlyBase:FBgn0004569, UniProt:Q00805]
exact_synonym: "aos" [FlyBase:FBgn0004569]
exact_synonym: "arg" [FlyBase:FBgn0004569]
exact_synonym: "argos" [FlyBase:FBgn0004569, UniProt:Q00805]
exact_synonym: "Argos" [FlyBase:FBgn0004569]
exact_synonym: "CG4531" [FlyBase:FBgn0004569]
exact_synonym: "giant lens" [FlyBase:FBgn0004569]
exact_synonym: "gil" [FlyBase:FBgn0004569, UniProt:Q00805]
exact_synonym: "l(3)05845" [FlyBase:FBgn0004569]
exact_synonym: "l(3)05959" [FlyBase:FBgn0004569]
exact_synonym: "l(3)j5E11" [FlyBase:FBgn0004569]
exact_synonym: "l(3)rJ472" [FlyBase:FBgn0004569]
exact_synonym: "l(3)rJ812" [FlyBase:FBgn0004569]
exact_synonym: "l(3)rQ526" [FlyBase:FBgn0004569]
exact_synonym: "Protein argos" [UniProt:Q00805]
exact_synonym: "Protein giant-lens" [UniProt:Q00805]
exact_synonym: "Protein strawberry" [UniProt:Q00805]
exact_synonym: "rlt" [FlyBase:FBgn0004569]
exact_synonym: "roulette" [FlyBase:FBgn0004569]
exact_synonym: "strawberry" [FlyBase:FBgn0004569]
exact_synonym: "sty" [FlyBase:FBgn0004569, UniProt:Q00805]
xref_analog: UniProt:Q00805
relationship: sequence_of IMR:0000428 ! signal regulator

[Term]
id: IMR:0002968
name: EGFR_DROME
def: "The Drosophila genome encodes a single locus of the EGFR/ ErbB family: Drosophila epidermal growth factor receptor (DER)." [PubMed:17092823]
exact_synonym: "C-erb" [FlyBase:FBgn0003731]
exact_synonym: "c-erbB" [UniProt:P04412, FlyBase:FBgn0003731]
exact_synonym: "CG10079" [FlyBase:FBgn0003731]
exact_synonym: "D-Egf" [FlyBase:FBgn0003731]
exact_synonym: "D-EGFR" [FlyBase:FBgn0003731]
exact_synonym: "dEGFR" [FlyBase:FBgn0003731]
exact_synonym: "Degfr" [FlyBase:FBgn0003731]
exact_synonym: "dEGFR1" [FlyBase:FBgn0003731]
exact_synonym: "DER" [UniProt:P04412, FlyBase:FBgn0003731]
exact_synonym: "Der" [FlyBase:FBgn0003731]
exact_synonym: "DER flb" [FlyBase:FBgn0003731]
exact_synonym: "DER-Ellipse" [FlyBase:FBgn0003731]
exact_synonym: "DER/EGFR" [FlyBase:FBgn0003731]
exact_synonym: "DER/faint little ball" [FlyBase:FBgn0003731]
exact_synonym: "DER/top" [FlyBase:FBgn0003731]
exact_synonym: "DER\\torpedo" [FlyBase:FBgn0003731]
exact_synonym: "DmHD-33" [FlyBase:FBgn0003731]
exact_synonym: "Drosophila epidermal growth factor receptor homologue" [FlyBase:FBgn0003731]
exact_synonym: "Drosophila relative of ERBB" [UniProt:P04412]
exact_synonym: "EC 2.7.10.1" [UniProt:P04412]
exact_synonym: "Egf" [FlyBase:FBgn0003731]
exact_synonym: "EGF receptor" [FlyBase:FBgn0003731]
exact_synonym: "EGF Receptor" [FlyBase:FBgn0003731]
exact_synonym: "EGF-R" [FlyBase:FBgn0003731]
exact_synonym: "Egf-r" [FlyBase:FBgn0003731]
exact_synonym: "EGF-receptor" [FlyBase:FBgn0003731]
exact_synonym: "Egfr" [UniProt:P04412, FlyBase:FBgn0003731]
exact_synonym: "EGFR" [FlyBase:FBgn0003731]
exact_synonym: "egfr" [FlyBase:FBgn0003731]
exact_synonym: "EgfR" [FlyBase:FBgn0003731]
exact_synonym: "EGFr" [FlyBase:FBgn0003731]
exact_synonym: "EK2-6" [FlyBase:FBgn0003731]
exact_synonym: "El" [FlyBase:FBgn0003731]
exact_synonym: "Ellipse" [FlyBase:FBgn0003731]
exact_synonym: "Ellipse torpedo" [FlyBase:FBgn0003731]
exact_synonym: "Elp" [FlyBase:FBgn0003731]
exact_synonym: "Elp-1" [FlyBase:FBgn0003731]
exact_synonym: "Elp-B1" [FlyBase:FBgn0003731]
exact_synonym: "Elp-B1RB1" [FlyBase:FBgn0003731]
exact_synonym: "Epidermal growth factor receptor" [UniProt:P04412, FlyBase:FBgn0003731]
exact_synonym: "epidermal growth factor receptor" [FlyBase:FBgn0003731]
exact_synonym: "faint little ball" [FlyBase:FBgn0003731]
exact_synonym: "flb" [FlyBase:FBgn0003731]
exact_synonym: "Gurken receptor" [UniProt:P04412]
exact_synonym: "HD-33" [FlyBase:FBgn0003731]
exact_synonym: "l(2)05351" [FlyBase:FBgn0003731]
exact_synonym: "l(2)09261" [FlyBase:FBgn0003731]
exact_synonym: "l(2)57DEFa" [FlyBase:FBgn0003731]
exact_synonym: "l(2)57Ea" [FlyBase:FBgn0003731]
exact_synonym: "l(2)57EFa" [FlyBase:FBgn0003731]
exact_synonym: "Protein torpedo" [UniProt:P04412]
exact_synonym: "top" [UniProt:P04412, FlyBase:FBgn0003731]
exact_synonym: "top/DER" [FlyBase:FBgn0003731]
exact_synonym: "top/flb" [FlyBase:FBgn0003731]
exact_synonym: "torpedo" [FlyBase:FBgn0003731]
exact_synonym: "Torpedo" [FlyBase:FBgn0003731]
exact_synonym: "torpedo/DER" [FlyBase:FBgn0003731]
exact_synonym: "Torpedo/DER" [FlyBase:FBgn0003731]
exact_synonym: "Torpedo/Egfr" [FlyBase:FBgn0003731]
exact_synonym: "torpedo/Egfr" [FlyBase:FBgn0003731]
exact_synonym: "torpedo/egfr" [FlyBase:FBgn0003731]
xref_analog: UniProt:P04412
relationship: sequence_of IMR:0000081 ! EGFR

[Term]
id: IMR:0002969
name: DRK_DROME
def: "A Drosophlla gene (drk) encodes a widely expressed protein with a single SH2 domain and two flanking SH3 domains, which is homologous to the Sem-5 protein of C. elegans and mammalian GRB2.\n" [PubMed:8462098]
exact_synonym: "24/1" [FlyBase:FBgn0004638]
exact_synonym: "CG6033" [FlyBase:FBgn0004638]
exact_synonym: "crkl" [FlyBase:FBgn0004638]
exact_synonym: "Downstream of receptor kinase" [UniProt:Q08012]
exact_synonym: "downstream of receptor kinase" [FlyBase:FBgn0004638]
exact_synonym: "drk" [UniProt:Q08012, FlyBase:FBgn0004638]
exact_synonym: "Drk" [FlyBase:FBgn0004638]
exact_synonym: "DRK" [FlyBase:FBgn0004638]
exact_synonym: "Drk/Grb2" [FlyBase:FBgn0004638]
exact_synonym: "E(sev)2B" [UniProt:Q08012, FlyBase:FBgn0004638]
exact_synonym: "Enhancer of sevenless-2B" [FlyBase:FBgn0004638]
exact_synonym: "Grb2/drk" [FlyBase:FBgn0004638]
exact_synonym: "l(2)10626" [FlyBase:FBgn0004638]
exact_synonym: "l(2)k13809" [FlyBase:FBgn0004638]
exact_synonym: "P1112" [FlyBase:FBgn0004638]
exact_synonym: "Protein E(sev)2B" [UniProt:Q08012]
exact_synonym: "Protein enhancer of sevenless 2B" [UniProt:Q08012]
exact_synonym: "SH2-SH3 adapter protein drk" [UniProt:Q08012]
exact_synonym: "Su(sev)R1" [FlyBase:FBgn0004638]
xref_analog: UniProt:Q08012
relationship: sequence_of IMR:0000340 ! Grb2

[Term]
id: IMR:0002970
name: SEM5_CAEEL
exact_synonym: "sem-5" [UniProt:P29355]
exact_synonym: "Sex muscle abnormal protein 5" [UniProt:P29355]
xref_analog: UniProt:P29355
relationship: sequence_of IMR:0000340 ! Grb2

[Term]
id: IMR:0002971
name: SOS_DROME
exact_synonym: "2.3" [FlyBase:FBgn0001965]
exact_synonym: "34Ea" [FlyBase:FBgn0001965]
exact_synonym: "BG:DS00941.4" [FlyBase:FBgn0001965]
exact_synonym: "br24" [FlyBase:FBgn0001965]
exact_synonym: "br25" [FlyBase:FBgn0001965]
exact_synonym: "CG7793" [FlyBase:FBgn0001965]
exact_synonym: "dme-SOS" [FlyBase:FBgn0001965]
exact_synonym: "dSos" [FlyBase:FBgn0001965]
exact_synonym: "E(sev)2A" [FlyBase:FBgn0001965]
exact_synonym: "E(var)189" [FlyBase:FBgn0001965]
exact_synonym: "EK2-8" [FlyBase:FBgn0001965]
exact_synonym: "EY2-3" [FlyBase:FBgn0001965]
exact_synonym: "l(2)34Ea" [FlyBase:FBgn0001965]
exact_synonym: "l(2)br24" [FlyBase:FBgn0001965]
exact_synonym: "l(2)br25" [FlyBase:FBgn0001965]
exact_synonym: "l(2)k05224" [FlyBase:FBgn0001965]
exact_synonym: "l(2)k06321" [FlyBase:FBgn0001965]
exact_synonym: "l(2)Sos" [FlyBase:FBgn0001965]
exact_synonym: "lethal 24 in the black-reduced region" [FlyBase:FBgn0001965]
exact_synonym: "lethal 25 in the black-reduced region" [FlyBase:FBgn0001965]
exact_synonym: "Protein son of sevenless" [UniProt:P26675]
exact_synonym: "Son of sevenless" [FlyBase:FBgn0001965]
exact_synonym: "Sos" [FlyBase:FBgn0001965, UniProt:P26675]
exact_synonym: "sos" [FlyBase:FBgn0001965]
exact_synonym: "SOS" [FlyBase:FBgn0001965]
exact_synonym: "Sos1" [FlyBase:FBgn0001965]
exact_synonym: "Su(tor)2-2" [FlyBase:FBgn0001965]
xref_analog: UniProt:P26675
relationship: sequence_of IMR:0000435 ! Sos

[Term]
id: IMR:0002972
name: RAS1_DROME
def: "Ras1 is the Drosophila homolog of the transforming genes Ha-ras, Ki-ras, and N-ras." [PubMed:6430564, PubMed:7749324]
exact_synonym: "C-ras1" [FlyBase:FBgn0003205]
exact_synonym: "CG9375" [FlyBase:FBgn0003205]
exact_synonym: "D-Ras" [FlyBase:FBgn0003205]
exact_synonym: "D-ras-1" [FlyBase:FBgn0003205]
exact_synonym: "D-Ras1" [FlyBase:FBgn0003205]
exact_synonym: "D-ras1" [FlyBase:FBgn0003205]
exact_synonym: "Dm Ras1" [FlyBase:FBgn0003205]
exact_synonym: "Dmras85D" [FlyBase:FBgn0003205, UniProt:P08646]
exact_synonym: "Dras" [FlyBase:FBgn0003205]
exact_synonym: "DRas" [FlyBase:FBgn0003205]
exact_synonym: "Dras1" [FlyBase:FBgn0003205, UniProt:P08646]
exact_synonym: "dRas1" [FlyBase:FBgn0003205]
exact_synonym: "dras1" [FlyBase:FBgn0003205]
exact_synonym: "DRAS1" [FlyBase:FBgn0003205]
exact_synonym: "dRAS1" [FlyBase:FBgn0003205]
exact_synonym: "Dras85D" [FlyBase:FBgn0003205]
exact_synonym: "DRas85D/Ras" [FlyBase:FBgn0003205]
exact_synonym: "E(faf)" [FlyBase:FBgn0003205]
exact_synonym: "E(sev)3C" [FlyBase:FBgn0003205]
exact_synonym: "EK3-4" [FlyBase:FBgn0003205]
exact_synonym: "Enhancer of faf" [FlyBase:FBgn0003205]
exact_synonym: "fs(3)05703" [FlyBase:FBgn0003205]
exact_synonym: "l(3)06677" [FlyBase:FBgn0003205]
exact_synonym: "l(3)s1747" [FlyBase:FBgn0003205]
exact_synonym: "p21[Ras1]" [FlyBase:FBgn0003205]
exact_synonym: "ras" [FlyBase:FBgn0003205]
exact_synonym: "Ras" [FlyBase:FBgn0003205]
exact_synonym: "RAS" [FlyBase:FBgn0003205]
exact_synonym: "ras 1" [FlyBase:FBgn0003205]
exact_synonym: "Ras GTPase" [FlyBase:FBgn0003205]
exact_synonym: "Ras oncogene at 85D" [FlyBase:FBgn0003205]
exact_synonym: "Ras-1" [FlyBase:FBgn0003205]
exact_synonym: "Ras-like protein 1" [UniProt:P08646]
exact_synonym: "Ras1" [FlyBase:FBgn0003205, UniProt:P08646]
exact_synonym: "RAS1" [FlyBase:FBgn0003205]
exact_synonym: "ras1" [FlyBase:FBgn0003205]
exact_synonym: "ras85B" [FlyBase:FBgn0003205]
exact_synonym: "Ras85D" [FlyBase:FBgn0003205, UniProt:P08646]
exact_synonym: "ras85D" [FlyBase:FBgn0003205]
exact_synonym: "RasI" [FlyBase:FBgn0003205]
exact_synonym: "RTK" [FlyBase:FBgn0003205]
exact_synonym: "S35097" [FlyBase:FBgn0003205]
exact_synonym: "Su(tor)3-2" [FlyBase:FBgn0003205]
xref_analog: UniProt:P08646
relationship: sequence_of IMR:0000290 ! Ras

[Term]
id: IMR:0002973
name: RAS2_DROME
exact_synonym: "BcDNA:RE36103" [FlyBase:FBgn0003206]
exact_synonym: "C-ras2" [FlyBase:FBgn0003206]
exact_synonym: "c-ras2" [FlyBase:FBgn0003206]
exact_synonym: "CG1167" [FlyBase:FBgn0003206]
exact_synonym: "D-ras-2" [FlyBase:FBgn0003206]
exact_synonym: "D-ras2" [FlyBase:FBgn0003206]
exact_synonym: "Dm-ras-64B" [FlyBase:FBgn0003206]
exact_synonym: "Dmras64B" [FlyBase:FBgn0003206]
exact_synonym: "Dras2" [FlyBase:FBgn0003206]
exact_synonym: "DRas2" [FlyBase:FBgn0003206]
exact_synonym: "Dras64B" [FlyBase:FBgn0003206]
exact_synonym: "ras" [FlyBase:FBgn0003206]
exact_synonym: "RAS" [FlyBase:FBgn0003206]
exact_synonym: "Ras" [FlyBase:FBgn0003206]
exact_synonym: "ras oncogene" [FlyBase:FBgn0003206]
exact_synonym: "Ras oncogene at 64B" [FlyBase:FBgn0003206]
exact_synonym: "ras-2" [FlyBase:FBgn0003206]
exact_synonym: "Ras-like protein 2" [UniProt:P04388]
exact_synonym: "ras2" [FlyBase:FBgn0003206, UniProt:P04388]
exact_synonym: "Ras2" [FlyBase:FBgn0003206]
exact_synonym: "Ras64B" [FlyBase:FBgn0003206, UniProt:P04388]
xref_analog: UniProt:P04388
relationship: sequence_of IMR:0000290 ! Ras

[Term]
id: IMR:0002974
name: RAS3_DROME
exact_synonym: "BEST:GH18528" [FlyBase:FBgn0004636]
exact_synonym: "C-ras3" [FlyBase:FBgn0004636]
exact_synonym: "CG1956" [FlyBase:FBgn0004636]
exact_synonym: "DRap" [FlyBase:FBgn0004636]
exact_synonym: "DRap1" [FlyBase:FBgn0004636]
exact_synonym: "Dras3" [FlyBase:FBgn0004636]
exact_synonym: "Dras62B" [FlyBase:FBgn0004636]
exact_synonym: "E(faf)" [FlyBase:FBgn0004636]
exact_synonym: "Enhancer of faf" [FlyBase:FBgn0004636]
exact_synonym: "l(3)62Bf" [FlyBase:FBgn0004636]
exact_synonym: "l(3)R" [FlyBase:FBgn0004636]
exact_synonym: "Protein roughened" [UniProt:P08645]
exact_synonym: "R" [UniProt:P08645, FlyBase:FBgn0004636]
exact_synonym: "RAP" [UniProt:P08645]
exact_synonym: "Rap" [FlyBase:FBgn0004636]
exact_synonym: "Rap1" [UniProt:P08645, FlyBase:FBgn0004636]
exact_synonym: "rap1" [FlyBase:FBgn0004636]
exact_synonym: "RAP1" [FlyBase:FBgn0004636]
exact_synonym: "ras 3" [FlyBase:FBgn0004636]
exact_synonym: "Ras-like protein 3" [UniProt:P08645]
exact_synonym: "ras3" [UniProt:P08645, FlyBase:FBgn0004636]
exact_synonym: "Ras3" [FlyBase:FBgn0004636]
exact_synonym: "Ras62B" [UniProt:P08645]
exact_synonym: "RasIII" [FlyBase:FBgn0004636]
exact_synonym: "Roughened" [FlyBase:FBgn0004636]
xref_analog: UniProt:P08645
relationship: sequence_of IMR:0000290 ! Ras

[Term]
id: IMR:0002975
name: KRAF1_DROME
def: "Draf is the sole Raf homolog in the fly genome and is 61% and 56% homologous to mammalian B-Raf and Raf-1 (C-Raf), respectively. " [PubMed:15704136]
exact_synonym: "11-29" [FlyBase:FBgn0003079]
exact_synonym: "C110" [FlyBase:FBgn0003079]
exact_synonym: "CG2845" [FlyBase:FBgn0003079]
exact_synonym: "D-Raf" [UniProt:P11346, FlyBase:FBgn0003079]
exact_synonym: "D-RAF" [FlyBase:FBgn0003079]
exact_synonym: "D-raf" [FlyBase:FBgn0003079]
exact_synonym: "D-raf1" [FlyBase:FBgn0003079]
exact_synonym: "DRaf" [FlyBase:FBgn0003079]
exact_synonym: "draf" [FlyBase:FBgn0003079]
exact_synonym: "Draf" [FlyBase:FBgn0003079]
exact_synonym: "dRAF-1" [UniProt:P11346]
exact_synonym: "Draf-1" [FlyBase:FBgn0003079]
exact_synonym: "Draf1" [FlyBase:FBgn0003079]
exact_synonym: "EC 2.7.11.1" [UniProt:P11346]
exact_synonym: "EG:BACH48C10.3" [FlyBase:FBgn0003079]
exact_synonym: "l(1)2Fe" [FlyBase:FBgn0003079]
exact_synonym: "l(1)G0475" [FlyBase:FBgn0003079]
exact_synonym: "l(1)ph" [FlyBase:FBgn0003079]
exact_synonym: "l(1)phl" [FlyBase:FBgn0003079]
exact_synonym: "l(1)pole hole" [FlyBase:FBgn0003079]
exact_synonym: "l(1)polehole" [FlyBase:FBgn0003079]
exact_synonym: "l(1)polehole/draf" [FlyBase:FBgn0003079]
exact_synonym: "l(1)raf" [FlyBase:FBgn0003079]
exact_synonym: "ph" [UniProt:P11346, FlyBase:FBgn0003079]
exact_synonym: "phl" [UniProt:P11346, FlyBase:FBgn0003079]
exact_synonym: "Pole hole" [FlyBase:FBgn0003079]
exact_synonym: "pole hole" [FlyBase:FBgn0003079]
exact_synonym: "pole-hole" [FlyBase:FBgn0003079]
exact_synonym: "Protein pole-hole" [UniProt:P11346]
exact_synonym: "Raf" [FlyBase:FBgn0003079]
exact_synonym: "RAF" [FlyBase:FBgn0003079]
exact_synonym: "raf" [FlyBase:FBgn0003079]
exact_synonym: "Raf homolog serine/threonine-protein kinase phl" [UniProt:P11346]
exact_synonym: "raf-1" [FlyBase:FBgn0003079]
exact_synonym: "raf-like-oncogene-1" [FlyBase:FBgn0003079]
exact_synonym: "Raf1" [FlyBase:FBgn0003079]
exact_synonym: "raf1" [FlyBase:FBgn0003079]
exact_synonym: "rafl" [FlyBase:FBgn0003079]
xref_analog: UniProt:P11346
relationship: sequence_of IMR:0000231 ! Raf

[Term]
id: IMR:0002976
name: KRAF1_CAEEL
exact_synonym: "Abnormal cell lineage protein 45" [UniProt:Q07292]
exact_synonym: "EC 2.7.11.1" [UniProt:Q07292]
exact_synonym: "lin-45" [UniProt:Q07292]
exact_synonym: "Raf homolog serine/threonine-protein kinase" [UniProt:Q07292]
exact_synonym: "raf-1" [UniProt:Q07292]
xref_analog: UniProt:Q07292
relationship: sequence_of IMR:0000231 ! Raf

[Term]
id: IMR:0002977
name: DSOR1_DROME
def: "Dsor1 encodes a Drosophila MEK1/2 homolog." [PubMed:15704136]
exact_synonym: "CG15793" [FlyBase:FBgn0010269]
exact_synonym: "D-Mek" [FlyBase:FBgn0010269]
exact_synonym: "D-mek" [FlyBase:FBgn0010269]
exact_synonym: "D-MEK" [FlyBase:FBgn0010269]
exact_synonym: "D-MEK/Dsor" [FlyBase:FBgn0010269]
exact_synonym: "D-SOR" [FlyBase:FBgn0010269]
exact_synonym: "D-sor" [FlyBase:FBgn0010269]
exact_synonym: "D-sor-1" [FlyBase:FBgn0010269]
exact_synonym: "Dmek" [FlyBase:FBgn0010269]
exact_synonym: "DMEK-1" [FlyBase:FBgn0010269]
exact_synonym: "Downstream of RAF" [UniProt:Q24324]
exact_synonym: "Downstream of raf1" [FlyBase:FBgn0010269]
exact_synonym: "DRODSOR1" [FlyBase:FBgn0010269]
exact_synonym: "Dsor" [FlyBase:FBgn0010269]
exact_synonym: "DSor" [FlyBase:FBgn0010269]
exact_synonym: "Dsor1" [FlyBase:FBgn0010269, UniProt:Q24324]
exact_synonym: "DSOR1" [FlyBase:FBgn0010269]
exact_synonym: "dsor1" [FlyBase:FBgn0010269]
exact_synonym: "DSor1" [FlyBase:FBgn0010269]
exact_synonym: "DSORT" [FlyBase:FBgn0010269]
exact_synonym: "Dual specificity mitogen-activated protein kinase kinase dSOR1" [UniProt:Q24324]
exact_synonym: "EC 2.7.12.2" [UniProt:Q24324]
exact_synonym: "EK1-1" [FlyBase:FBgn0010269]
exact_synonym: "MAPKK" [FlyBase:FBgn0010269, UniProt:Q24324]
exact_synonym: "mek" [FlyBase:FBgn0010269]
exact_synonym: "Mek" [FlyBase:FBgn0010269]
exact_synonym: "MEK" [FlyBase:FBgn0010269]
exact_synonym: "MEK1/2" [FlyBase:FBgn0010269]
exact_synonym: "sor" [FlyBase:FBgn0010269]
exact_synonym: "SOR" [FlyBase:FBgn0010269]
exact_synonym: "sor/MEK1" [FlyBase:FBgn0010269]
exact_synonym: "Su(Raf)34B" [FlyBase:FBgn0010269]
xref_analog: UniProt:Q24324
relationship: sequence_of IMR:0000261 ! MEK1/2(MKK1/2)

[Term]
id: IMR:0002978
name: ERKA_DROME
def: "The Drosophila genome has representatives of each of the three MAPK subfamilies found in other animals: one extracellular signal-related kinase [ERK; rolled (rl)], one Jun N-terminal kinase [JNK; basket (bsk)], and p38 (encoded by the two genes Mpk2 and p38b)." [PubMed:18820472]
exact_synonym: "BcDNA:RE08694" [FlyBase:FBgn0003256]
exact_synonym: "CG12559" [FlyBase:FBgn0003256]
exact_synonym: "CG18732" [FlyBase:FBgn0003256]
exact_synonym: "CT34260" [FlyBase:FBgn0003256]
exact_synonym: "CT39192" [FlyBase:FBgn0003256]
exact_synonym: "D-ERK" [FlyBase:FBgn0003256]
exact_synonym: "DERK" [FlyBase:FBgn0003256]
exact_synonym: "DERK-A" [FlyBase:FBgn0003256]
exact_synonym: "DmErk" [FlyBase:FBgn0003256]
exact_synonym: "DmERK-A" [FlyBase:FBgn0003256]
exact_synonym: "DmERKA" [FlyBase:FBgn0003256]
exact_synonym: "DmMAPK" [FlyBase:FBgn0003256]
exact_synonym: "dp-ERK" [FlyBase:FBgn0003256]
exact_synonym: "dpERK" [FlyBase:FBgn0003256]
exact_synonym: "dpErk" [FlyBase:FBgn0003256]
exact_synonym: "dpMAPK" [FlyBase:FBgn0003256]
exact_synonym: "Dsor2" [FlyBase:FBgn0003256]
exact_synonym: "E(sina)7" [FlyBase:FBgn0003256]
exact_synonym: "EC 2.7.11.24" [UniProt:P40417]
exact_synonym: "EK2-1" [FlyBase:FBgn0003256]
exact_synonym: "Enhancer of seven in absentia 7" [FlyBase:FBgn0003256]
exact_synonym: "Erk" [FlyBase:FBgn0003256]
exact_synonym: "erk" [FlyBase:FBgn0003256]
exact_synonym: "ERK" [FlyBase:FBgn0003256]
exact_synonym: "Erk MAP kinase" [FlyBase:FBgn0003256]
exact_synonym: "ERK-A" [FlyBase:FBgn0003256]
exact_synonym: "Erk/Map kinase" [FlyBase:FBgn0003256]
exact_synonym: "Erk1" [FlyBase:FBgn0003256]
exact_synonym: "ERKa" [UniProt:P40417, FlyBase:FBgn0003256]
exact_synonym: "ErkA" [FlyBase:FBgn0003256]
exact_synonym: "ERKA" [FlyBase:FBgn0003256]
exact_synonym: "Extracellular-regulated kinase A" [UniProt:P40417, FlyBase:FBgn0003256]
exact_synonym: "Extracellular-signal-related kinase A" [FlyBase:FBgn0003256]
exact_synonym: "EY2-2" [FlyBase:FBgn0003256]
exact_synonym: "GroupII" [FlyBase:FBgn0003256]
exact_synonym: "l(2)41Ac" [FlyBase:FBgn0003256]
exact_synonym: "l(2R)EMS45-39" [FlyBase:FBgn0003256]
exact_synonym: "MAP kinase" [FlyBase:FBgn0003256]
exact_synonym: "MAP-kinase" [FlyBase:FBgn0003256]
exact_synonym: "MAPK" [FlyBase:FBgn0003256]
exact_synonym: "Mapk" [FlyBase:FBgn0003256]
exact_synonym: "mapk" [FlyBase:FBgn0003256]
exact_synonym: "Mitogen-activated protein kinase ERK-A" [UniProt:P40417]
exact_synonym: "pERK" [FlyBase:FBgn0003256]
exact_synonym: "Protein rolled" [UniProt:P40417]
exact_synonym: "rl" [UniProt:P40417, FlyBase:FBgn0003256]
exact_synonym: "rl/MAPK" [FlyBase:FBgn0003256]
exact_synonym: "rll" [FlyBase:FBgn0003256]
exact_synonym: "rolled" [FlyBase:FBgn0003256]
exact_synonym: "Sem" [FlyBase:FBgn0003256]
exact_synonym: "Sevenmaker" [FlyBase:FBgn0003256]
exact_synonym: "sevenmaker" [FlyBase:FBgn0003256]
exact_synonym: "SR2-1" [FlyBase:FBgn0003256]
exact_synonym: "Su(Raf)2B" [FlyBase:FBgn0003256]
xref_analog: UniProt:P40417
relationship: sequence_of IMR:0000227 ! ERK1/2

[Term]
id: IMR:0002979
name: PNT2_DROME
def: "pnt gene transcription generates alternatively spliced mRNA isoforms that encode two proteins, PntP1 and PntP2.\nPntP2 is the homolog of the human Ets-1 transcription factor and functions as a transcriptional activator when phosphorylated by MAPK." [PubMed:11175357, PubMed:11175366, PubMed:17092823, PubMed:8223245]
exact_synonym: "0123/09" [FlyBase:FBgn0003118]
exact_synonym: "0608/07" [FlyBase:FBgn0003118]
exact_synonym: "0998/12" [FlyBase:FBgn0003118]
exact_synonym: "3520" [FlyBase:FBgn0003118]
exact_synonym: "CG17077" [FlyBase:FBgn0003118]
exact_synonym: "D-ETS-2" [UniProt:P51023]
exact_synonym: "D-ets-2" [FlyBase:FBgn0003118]
exact_synonym: "D-Ets-2" [FlyBase:FBgn0003118]
exact_synonym: "DMPOINT1A" [FlyBase:FBgn0003118]
exact_synonym: "E(E2F)3D" [FlyBase:FBgn0003118]
exact_synonym: "EK3-2" [FlyBase:FBgn0003118]
exact_synonym: "Ets at 58AB" [FlyBase:FBgn0003118]
exact_synonym: "Ets protein Pointed P2" [FlyBase:FBgn0003118]
exact_synonym: "ETS-like protein pointed, isoform P2/D" [UniProt:P51023]
exact_synonym: "ETS2" [FlyBase:FBgn0003118, UniProt:P51023]
exact_synonym: "Ets2" [FlyBase:FBgn0003118]
exact_synonym: "Ets58AB" [FlyBase:FBgn0003118, UniProt:P51023]
exact_synonym: "ets94F" [FlyBase:FBgn0003118]
exact_synonym: "Ets94F" [FlyBase:FBgn0003118]
exact_synonym: "EY3-1" [FlyBase:FBgn0003118]
exact_synonym: "l(3)07825" [FlyBase:FBgn0003118]
exact_synonym: "l(3)j1B7" [FlyBase:FBgn0003118]
exact_synonym: "pnt" [FlyBase:FBgn0003118, UniProt:P51023]
exact_synonym: "PNTP1" [FlyBase:FBgn0003118]
exact_synonym: "PNTP2" [FlyBase:FBgn0003118]
exact_synonym: "POINT" [FlyBase:FBgn0003118]
exact_synonym: "pointed" [FlyBase:FBgn0003118]
exact_synonym: "pointed-P1" [FlyBase:FBgn0003118]
exact_synonym: "pointed-P2" [FlyBase:FBgn0003118]
exact_synonym: "pointed-RC" [FlyBase:FBgn0003118]
exact_synonym: "pointedP2" [FlyBase:FBgn0003118]
exact_synonym: "ptd" [FlyBase:FBgn0003118]
xref_analog: UniProt:P51023
relationship: sequence_of IMR:0000399 ! ETS1

[Term]
id: IMR:0002980
name: TEL1
exact_synonym: "ETV6" []
exact_synonym: "TEL" []
is_a: IMR:0000397 ! ets

[Term]
id: IMR:0002981
name: ETV6_HUMAN
exact_synonym: "ETS translocation variant 6" [UniProt:P41212]
exact_synonym: "ets variant 6" [EntrezGene:2120, HGNC:3495]
exact_synonym: "ETS VARIANT GENE 6" [MIM:600618]
exact_synonym: "ETS-related protein Tel1" [UniProt:P41212]
exact_synonym: "ETV6" [MIM:600618, UniProt:P41212, EntrezGene:2120, HGNC:3495]
exact_synonym: "TEL" [MIM:600618, UniProt:P41212, EntrezGene:2120, HGNC:3495]
exact_synonym: "Tel" [UniProt:P41212]
exact_synonym: "TEL/ABL" [EntrezGene:2120]
exact_synonym: "TEL1" [UniProt:P41212]
exact_synonym: "TEL1 ONCOGENE" [MIM:600618]
exact_synonym: "Transcription factor ETV6" [UniProt:P41212]
exact_synonym: "TRANSLOCATION, ETS, LEUKEMIA" [MIM:600618]
xref_analog: UniProt:P41212
relationship: sequence_of IMR:0002980 ! TEL1

[Term]
id: IMR:0002982
name: ETV6_MOUSE
exact_synonym: "ETS translocation variant 6" [UniProt:P97360]
exact_synonym: "ets variant gene 6 (TEL oncogene)" [MGI:109336]
exact_synonym: "ETS-related protein Tel1" [UniProt:P97360]
exact_synonym: "Etv6" [UniProt:P97360, MGI:109336]
exact_synonym: "Tel" [UniProt:P97360, MGI:109336]
exact_synonym: "Tel1" [UniProt:P97360]
exact_synonym: "Transcription factor ETV6" [UniProt:P97360]
exact_synonym: "translocation-ets-leukemia" [MGI:109336]
xref_analog: UniProt:P97360
relationship: sequence_of IMR:0002980 ! TEL1

[Term]
id: IMR:0002983
name: POK_DROME
def: "Yan is the homolog of the human Tel1 protein and is a transcriptional repressor." [PubMed:11175357, PubMed:11175366, PubMed:17092823]
exact_synonym: "anterior open" [FlyBase:FBgn0000097]
exact_synonym: "aop" [UniProt:Q01842, FlyBase:FBgn0000097]
exact_synonym: "Aop" [FlyBase:FBgn0000097]
exact_synonym: "Aop/Yan" [FlyBase:FBgn0000097]
exact_synonym: "aop/yan" [FlyBase:FBgn0000097]
exact_synonym: "CG3166" [FlyBase:FBgn0000097]
exact_synonym: "DROYANET" [FlyBase:FBgn0000097]
exact_synonym: "DROYANETSB" [FlyBase:FBgn0000097]
exact_synonym: "Ets DNA-binding protein pokkuri" [UniProt:Q01842]
exact_synonym: "pok" [UniProt:Q01842, FlyBase:FBgn0000097]
exact_synonym: "pokkuri" [FlyBase:FBgn0000097]
exact_synonym: "Protein anterior open" [UniProt:Q01842]
exact_synonym: "Protein yan" [UniProt:Q01842]
exact_synonym: "SK2-1" [FlyBase:FBgn0000097]
exact_synonym: "Yan" [UniProt:Q01842, FlyBase:FBgn0000097]
exact_synonym: "yan" [FlyBase:FBgn0000097]
exact_synonym: "YAN" [FlyBase:FBgn0000097]
exact_synonym: "yan/pok" [FlyBase:FBgn0000097]
xref_analog: UniProt:Q01842
relationship: sequence_of IMR:0002980 ! TEL1

[Term]
id: IMR:0002984
name: XPO1_MOUSE
exact_synonym: "Chromosome region maintenance 1 protein homolog" [UniProt:Q6P5F9]
exact_synonym: "Crm1" [UniProt:Q6P5F9, MGI:2144013]
exact_synonym: "Exp1" [UniProt:Q6P5F9]
exact_synonym: "exportin 1, CRM1 homolog (yeast)" [MGI:2144013]
exact_synonym: "Exportin-1" [UniProt:Q6P5F9]
exact_synonym: "Xpo1" [UniProt:Q6P5F9, MGI:2144013]
xref_analog: UniProt:Q6P5F9
relationship: sequence_of IMR:0001090 ! CRM1

[Term]
id: IMR:0002985
name: XPO1_RAT
exact_synonym: "Chromosome region maintenance 1 protein homolog" [UniProt:Q80U96]
exact_synonym: "Crm1" [UniProt:Q80U96]
exact_synonym: "Exp1" [UniProt:Q80U96]
exact_synonym: "exportin 1, CRM1 homolog (yeast)" [RGD:620517]
exact_synonym: "Exportin-1" [UniProt:Q80U96]
exact_synonym: "Xpo1" [RGD:620517, UniProt:Q80U96]
xref_analog: UniProt:Q80U96
relationship: sequence_of IMR:0001090 ! CRM1

[Term]
id: IMR:0002986
name: XPO1_DROME
exact_synonym: "CG13387" [FlyBase:FBgn0020497]
exact_synonym: "Chromosomal region maintenance 1" [FlyBase:FBgn0020497]
exact_synonym: "Chromosome region maintenance 1 protein" [UniProt:Q9TVM2]
exact_synonym: "Crm1" [UniProt:Q9TVM2, FlyBase:FBgn0020497]
exact_synonym: "CRM1" [FlyBase:FBgn0020497]
exact_synonym: "crm1" [FlyBase:FBgn0020497]
exact_synonym: "dCRM1" [FlyBase:FBgn0020497]
exact_synonym: "emb" [UniProt:Q9TVM2, FlyBase:FBgn0020497]
exact_synonym: "embargoed" [FlyBase:FBgn0020497]
exact_synonym: "Exportin" [FlyBase:FBgn0020497]
exact_synonym: "Exportin-1" [UniProt:Q9TVM2]
exact_synonym: "l(2)k16715" [FlyBase:FBgn0020497]
exact_synonym: "Protein embargoed" [UniProt:Q9TVM2]
xref_analog: UniProt:Q9TVM2
relationship: sequence_of IMR:0001090 ! CRM1

[Term]
id: IMR:0002987
name: Q7K119_DROME
def: "MAE is a regulator of the EGFR signaling pathway." [PubMed:11357138, PubMed:15511639, PubMed:16362034, PubMed:17092823]
exact_synonym: "anon-WO02077276.2" [FlyBase:FBgn0023214]
exact_synonym: "anon-WO02077276.3" [FlyBase:FBgn0023214]
exact_synonym: "CG15085" [FlyBase:FBgn0023214]
exact_synonym: "edl" [UniProt:Q7K119, FlyBase:FBgn0023214]
exact_synonym: "EDL" [FlyBase:FBgn0023214]
exact_synonym: "Edl" [FlyBase:FBgn0023214]
exact_synonym: "edl/mae" [FlyBase:FBgn0023214]
exact_synonym: "ETS-domain lacking" [UniProt:Q7K119, FlyBase:FBgn0023214]
exact_synonym: "l(2)k06602" [FlyBase:FBgn0023214]
exact_synonym: "LD15796p" [UniProt:Q7K119]
exact_synonym: "MAE" [UniProt:Q7K119]
exact_synonym: "mae" [UniProt:Q7K119, FlyBase:FBgn0023214]
exact_synonym: "Mae" [FlyBase:FBgn0023214]
exact_synonym: "modulator of the activity of Ets" [FlyBase:FBgn0023214]
xref_analog: UniProt:Q7K119
relationship: sequence_of IMR:0000428 ! signal regulator

[Term]
id: IMR:0002988
name: Q9VK54_DROME
def: "Kekkon is a transmembrane protein that binds the DER extracellular domain and attenuates receptor dimerization." [PubMed:12648473]
exact_synonym: "BEST:GM02380" [FlyBase:FBgn0015399]
exact_synonym: "CG12283" [FlyBase:FBgn0015399]
exact_synonym: "CT18186" [FlyBase:FBgn0015399]
exact_synonym: "Dmkek1" [FlyBase:FBgn0015399]
exact_synonym: "GM02380" [FlyBase:FBgn0015399]
exact_synonym: "Kek" [FlyBase:FBgn0015399]
exact_synonym: "kek" [FlyBase:FBgn0015399]
exact_synonym: "kek-1" [FlyBase:FBgn0015399]
exact_synonym: "Kek-1" [FlyBase:FBgn0015399]
exact_synonym: "kek1" [UniProt:Q9VK54, FlyBase:FBgn0015399]
exact_synonym: "KEK1" [FlyBase:FBgn0015399]
exact_synonym: "Kek1" [FlyBase:FBgn0015399]
exact_synonym: "Kekkon" [FlyBase:FBgn0015399]
exact_synonym: "kekkon" [FlyBase:FBgn0015399]
exact_synonym: "Kekkon-1" [UniProt:Q9VK54, FlyBase:FBgn0015399]
exact_synonym: "kekkon-1" [FlyBase:FBgn0015399]
exact_synonym: "kekkon1" [FlyBase:FBgn0015399]
exact_synonym: "kekkonI" [FlyBase:FBgn0015399]
exact_synonym: "kekon" [FlyBase:FBgn0015399]
exact_synonym: "Kekon-1" [FlyBase:FBgn0015399]
exact_synonym: "l(2)01433" [FlyBase:FBgn0015399]
exact_synonym: "n(2)k07332" [FlyBase:FBgn0015399]
exact_synonym: "NB1" [FlyBase:FBgn0015399]
exact_synonym: "SD01674" [FlyBase:FBgn0015399]
exact_synonym: "uns" [FlyBase:FBgn0015399]
exact_synonym: "unstrung" [FlyBase:FBgn0015399]
xref_analog: UniProt:Q9VK54
relationship: sequence_of IMR:0000428 ! signal regulator

[Term]
id: IMR:0002989
name: CSW_DROME
def: "Corkscrew (Csw) encodes a nonreceptor protein tyrosine phosphatase (PTPase) with two N-terminal SH2 domains and a C-terminal catalytic region. SHP-2 encodes a structural and functional vertebrate homologue of Csw." [PubMed:16481357, PubMed:8948575]
exact_synonym: "19-106" [FlyBase:FBgn0000382]
exact_synonym: "anon-WO03040301.207" [FlyBase:FBgn0000382]
exact_synonym: "anon-WO03040301.209" [FlyBase:FBgn0000382]
exact_synonym: "anon-WO03040301.219" [FlyBase:FBgn0000382]
exact_synonym: "CG3954" [FlyBase:FBgn0000382]
exact_synonym: "corkscrew" [FlyBase:FBgn0000382]
exact_synonym: "csw" [FlyBase:FBgn0000382, UniProt:P29349]
exact_synonym: "CSW" [FlyBase:FBgn0000382]
exact_synonym: "Csw" [FlyBase:FBgn0000382]
exact_synonym: "Csw/Shp2" [FlyBase:FBgn0000382]
exact_synonym: "E(sev)1A" [FlyBase:FBgn0000382]
exact_synonym: "EC 3.1.3.48" [UniProt:P29349]
exact_synonym: "EG:BACN25G24.2" [FlyBase:FBgn0000382]
exact_synonym: "Enhancer of sevenless 1A" [FlyBase:FBgn0000382]
exact_synonym: "l(1)2Db" [FlyBase:FBgn0000382]
exact_synonym: "l(1)2Dd" [FlyBase:FBgn0000382]
exact_synonym: "l(1)csw" [FlyBase:FBgn0000382]
exact_synonym: "l(1)G0170" [FlyBase:FBgn0000382]
exact_synonym: "l(1)GA114" [FlyBase:FBgn0000382]
exact_synonym: "Tyrosine-protein phosphatase corkscrew" [UniProt:P29349]
xref_analog: UniProt:P29349
relationship: sequence_of IMR:0000276 ! SHP-2

[Term]
id: IMR:0002990
name: O96757_DROME
def: "Dof functions as a adaptor protein that links the FGF receptor to downstream signaling components instead of vertebrate FRS2. The Dof homologs in vertebrates, BCAP and BANK, are both implicated in mediating signaling events downstream of the B-cell receptor." [PubMed:14993266, PubMed:15082772, PubMed:15863031]
exact_synonym: "0837/10" [FlyBase:FBgn0020299]
exact_synonym: "anon-EST:CL47" [FlyBase:FBgn0020299]
exact_synonym: "anon-estC" [FlyBase:FBgn0020299]
exact_synonym: "C" [FlyBase:FBgn0020299]
exact_synonym: "CG18485" [FlyBase:FBgn0020299]
exact_synonym: "CG31317" [FlyBase:FBgn0020299]
exact_synonym: "CG3375" [FlyBase:FBgn0020299]
exact_synonym: "dof" [FlyBase:FBgn0020299, UniProt:O96757]
exact_synonym: "Dof" [FlyBase:FBgn0020299]
exact_synonym: "DOF" [FlyBase:FBgn0020299]
exact_synonym: "Dof protein" [UniProt:O96757]
exact_synonym: "dof/hbr" [FlyBase:FBgn0020299]
exact_synonym: "dof/hbr/sms" [FlyBase:FBgn0020299]
exact_synonym: "Dof/stumps/heartbroken" [FlyBase:FBgn0020299]
exact_synonym: "Downstream of FGF" [FlyBase:FBgn0020299]
exact_synonym: "downstream of FGF receptor" [FlyBase:FBgn0020299]
exact_synonym: "Downstream of FGF receptor" [FlyBase:FBgn0020299]
exact_synonym: "Downstream of FGFR" [FlyBase:FBgn0020299]
exact_synonym: "downstream of FGFR" [FlyBase:FBgn0020299]
exact_synonym: "gene C" [FlyBase:FBgn0020299]
exact_synonym: "hbr" [FlyBase:FBgn0020299]
exact_synonym: "Hbr/Dof" [FlyBase:FBgn0020299]
exact_synonym: "heartbroken" [FlyBase:FBgn0020299]
exact_synonym: "Heartbroken" [FlyBase:FBgn0020299]
exact_synonym: "heartbroken/dof" [FlyBase:FBgn0020299]
exact_synonym: "i21" [FlyBase:FBgn0020299]
exact_synonym: "i28" [FlyBase:FBgn0020299]
exact_synonym: "l(3)09904" [FlyBase:FBgn0020299]
exact_synonym: "l(3)S083710" [FlyBase:FBgn0020299]
exact_synonym: "P1740" [FlyBase:FBgn0020299]
exact_synonym: "sms" [FlyBase:FBgn0020299]
exact_synonym: "stumps" [FlyBase:FBgn0020299, UniProt:O96757]
exact_synonym: "Stumps" [FlyBase:FBgn0020299]
exact_synonym: "stumps/dof" [FlyBase:FBgn0020299]
xref_analog: UniProt:O96757
relationship: sequence_of IMR:0000333 ! adaptor protein

[Term]
id: IMR:0002991
name: FGFR2_DROME
def: "The Drosophila genome includes two homologues of vertebrate FGF-R genes, DFR1and DFR2." [PubMed:8330538]
exact_synonym: "0844/01" [FlyBase:FBgn0005592]
exact_synonym: "breathless" [FlyBase:FBgn0005592]
exact_synonym: "btl" [FlyBase:FBgn0005592, UniProt:Q09147]
exact_synonym: "Btl" [FlyBase:FBgn0005592]
exact_synonym: "BTL/FGFR2" [FlyBase:FBgn0005592]
exact_synonym: "CG32134" [FlyBase:FBgn0005592]
exact_synonym: "CG6714" [FlyBase:FBgn0005592]
exact_synonym: "CT20816" [FlyBase:FBgn0005592]
exact_synonym: "D-FGFR" [FlyBase:FBgn0005592]
exact_synonym: "dev" [FlyBase:FBgn0005592]
exact_synonym: "devenir" [FlyBase:FBgn0005592]
exact_synonym: "dFGF-R1" [UniProt:Q09147]
exact_synonym: "DFGF-R1" [FlyBase:FBgn0005592]
exact_synonym: "Dfr-2" [FlyBase:FBgn0005592]
exact_synonym: "DFR2" [FlyBase:FBgn0005592]
exact_synonym: "DmHD-311" [FlyBase:FBgn0005592]
exact_synonym: "dTk2" [UniProt:Q09147]
exact_synonym: "Dtk2" [FlyBase:FBgn0005592]
exact_synonym: "dtk2" [FlyBase:FBgn0005592]
exact_synonym: "EC 2.7.10.1" [UniProt:Q09147]
exact_synonym: "FGF receptor" [FlyBase:FBgn0005592]
exact_synonym: "Fgf-r" [FlyBase:FBgn0005592]
exact_synonym: "fgf-r" [FlyBase:FBgn0005592]
exact_synonym: "FGFR" [FlyBase:FBgn0005592]
exact_synonym: "FGFR1" [FlyBase:FBgn0005592]
exact_synonym: "Fibroblast growth factor receptor homolog 2" [UniProt:Q09147]
exact_synonym: "Fibroblast-growth-factor-receptor" [FlyBase:FBgn0005592]
exact_synonym: "FR2" [UniProt:Q09147]
exact_synonym: "HD-311" [FlyBase:FBgn0005592, UniProt:Q09147]
exact_synonym: "l(3)00208" [FlyBase:FBgn0005592]
exact_synonym: "Protein breathless" [UniProt:Q09147]
exact_synonym: "Tk2" [FlyBase:FBgn0005592, UniProt:Q09147]
exact_synonym: "Tyrosine kinase 2" [UniProt:Q09147]
exact_synonym: "Tyrosine kinase receptor HD-311" [UniProt:Q09147]
xref_analog: UniProt:Q09147
relationship: sequence_of IMR:0000080 ! FGFR

[Term]
id: IMR:0002992
name: FGFR1_DROME
def: "The Drosophila genome includes two homologues of vertebrate FGF-R genes, DFR1and DFR2." [PubMed:8330538]
exact_synonym: "CG7223" [FlyBase:FBgn0010389]
exact_synonym: "CT22273" [FlyBase:FBgn0010389]
exact_synonym: "CT39172" [FlyBase:FBgn0010389]
exact_synonym: "DFGF-R1" [FlyBase:FBgn0010389]
exact_synonym: "DFGF-R2" [FlyBase:FBgn0010389]
exact_synonym: "DFR-1" [FlyBase:FBgn0010389]
exact_synonym: "Dfr-1" [FlyBase:FBgn0010389]
exact_synonym: "Dfr1" [FlyBase:FBgn0010389]
exact_synonym: "DFR1" [FlyBase:FBgn0010389]
exact_synonym: "DFR1/DFGF-R2" [FlyBase:FBgn0010389]
exact_synonym: "DmHD-38" [UniProt:Q07407, FlyBase:FBgn0010389]
exact_synonym: "DPR3" [FlyBase:FBgn0010389]
exact_synonym: "dTk1" [UniProt:Q07407]
exact_synonym: "dtk1" [FlyBase:FBgn0010389]
exact_synonym: "Dtk1" [FlyBase:FBgn0010389]
exact_synonym: "DTRK(FR1)" [FlyBase:FBgn0010389]
exact_synonym: "EC 2.7.10.1" [UniProt:Q07407]
exact_synonym: "EMS2" [FlyBase:FBgn0010389]
exact_synonym: "FGF receptor" [FlyBase:FBgn0010389]
exact_synonym: "FGF-R2" [FlyBase:FBgn0010389]
exact_synonym: "FGFR" [FlyBase:FBgn0010389]
exact_synonym: "FGFR2" [FlyBase:FBgn0010389]
exact_synonym: "fibroblast growth factor receptor" [FlyBase:FBgn0010389]
exact_synonym: "Fibroblast growth factor receptor 1" [FlyBase:FBgn0010389]
exact_synonym: "Fibroblast growth factor receptor homolog 1" [UniProt:Q07407]
exact_synonym: "FR1" [UniProt:Q07407, FlyBase:FBgn0010389]
exact_synonym: "Fr1" [FlyBase:FBgn0010389]
exact_synonym: "HD-38" [FlyBase:FBgn0010389]
exact_synonym: "heartless" [FlyBase:FBgn0010389]
exact_synonym: "htl" [UniProt:Q07407, FlyBase:FBgn0010389]
exact_synonym: "Htl" [FlyBase:FBgn0010389]
exact_synonym: "HTL/FGFR1" [FlyBase:FBgn0010389]
exact_synonym: "i100" [FlyBase:FBgn0010389]
exact_synonym: "i150" [FlyBase:FBgn0010389]
exact_synonym: "i79" [FlyBase:FBgn0010389]
exact_synonym: "j372" [FlyBase:FBgn0010389]
exact_synonym: "Protein heartless" [UniProt:Q07407]
exact_synonym: "Tk1" [UniProt:Q07407, FlyBase:FBgn0010389]
exact_synonym: "Tyrosine kinase 1" [UniProt:Q07407]
xref_analog: UniProt:Q07407
relationship: sequence_of IMR:0000080 ! FGFR

[Term]
id: IMR:0002993
name: P91672_DROME
def: "branchless Encodes a Drosophila FGF Homolog." [PubMed:15075295, PubMed:8978613]
exact_synonym: "bnl" [UniProt:P91672, FlyBase:FBgn0014135]
exact_synonym: "Bnl" [FlyBase:FBgn0014135]
exact_synonym: "branchless" [UniProt:P91672, FlyBase:FBgn0014135]
exact_synonym: "CG4608" [FlyBase:FBgn0014135]
exact_synonym: "DFGF" [FlyBase:FBgn0014135]
exact_synonym: "FGF" [FlyBase:FBgn0014135]
exact_synonym: "FGF homolog" [UniProt:P91672]
exact_synonym: "fibroblast growth factor" [FlyBase:FBgn0014135]
exact_synonym: "l(3)06916" [FlyBase:FBgn0014135]
exact_synonym: "l(3)neo52" [FlyBase:FBgn0014135]
xref_analog: UniProt:P91672
relationship: sequence_of IMR:0000049 ! FGF

[Term]
id: IMR:0002994
name: Q6Q7I9_DROME
def: "ths and pyr are two closely linked genes with homology to the FGF8/17/18 subfamily in vertebrates." [PubMed:15075295, PubMed:15863031]
exact_synonym: "CG12443" [FlyBase:FBgn0033652]
exact_synonym: "DFGF8-1" [FlyBase:FBgn0033652]
exact_synonym: "fgf8-like" [FlyBase:FBgn0033652]
exact_synonym: "FGF8-like1" [FlyBase:FBgn0033652]
exact_synonym: "Neu4" [FlyBase:FBgn0033652]
exact_synonym: "Thisbe" [UniProt:Q6Q7I9]
exact_synonym: "thisbe" [FlyBase:FBgn0033652]
exact_synonym: "ths" [FlyBase:FBgn0033652, UniProt:Q6Q7I9]
xref_analog: UniProt:Q6Q7I9
relationship: sequence_of IMR:0000049 ! FGF

[Term]
id: IMR:0002995
name: B9ZW35_DROME
def: "ths and pyr are two closely linked genes with homology to the FGF8/17/18 subfamily in vertebrates." [PubMed:15075295, PubMed:15863031]
exact_synonym: "CG13194" [FlyBase:FBgn0033649]
exact_synonym: "DFGF8-2" [FlyBase:FBgn0033649]
exact_synonym: "fgf8-like" [FlyBase:FBgn0033649]
exact_synonym: "FGF8-like2" [FlyBase:FBgn0033649]
exact_synonym: "pyr" [FlyBase:FBgn0033649, UniProt:B9ZW35]
exact_synonym: "Pyramus" [UniProt:B9ZW35]
exact_synonym: "pyramus" [FlyBase:FBgn0033649]
xref_analog: UniProt:B9ZW35
relationship: sequence_of IMR:0000049 ! FGF

[Term]
id: IMR:0002996
name: SRF
def: "Serum response factor (SRF) is a transcription factor, which binds to a serum response element (SRE) associated with a variety of genes." [PubMed:12120892, PubMed:12788374]
exact_synonym: "serum response factor" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0002997
name: SRF_HUMAN
exact_synonym: "C-FOS SERUM RESPONSE ELEMENT-BINDING FACTOR" [MIM:600589]
exact_synonym: "MCM1" [HGNC:11291, EntrezGene:6722]
exact_synonym: "Serum response factor" [UniProt:P11831, MIM:600589]
exact_synonym: "serum response factor (c-fos serum response element-binding transcription factor)" [HGNC:11291, EntrezGene:6722]
exact_synonym: "SRF" [UniProt:P11831, HGNC:11291, EntrezGene:6722, MIM:600589]
xref_analog: UniProt:P11831
relationship: sequence_of IMR:0002996 ! SRF

[Term]
id: IMR:0002998
name: SRF_MOUSE
exact_synonym: "Serum response factor" [UniProt:Q9JM73]
exact_synonym: "serum response factor" [MGI:106658]
exact_synonym: "SRF" [UniProt:Q9JM73]
exact_synonym: "Srf" [UniProt:Q9JM73, MGI:106658]
xref_analog: UniProt:Q9JM73
relationship: sequence_of IMR:0002996 ! SRF

[Term]
id: IMR:0002999
name: SRF_DROME
exact_synonym: "ba" [FlyBase:FBgn0004101]
exact_synonym: "balloon" [FlyBase:FBgn0004101]
exact_synonym: "blistered" [FlyBase:FBgn0004101]
exact_synonym: "bs" [UniProt:Q24535, FlyBase:FBgn0004101]
exact_synonym: "BS" [FlyBase:FBgn0004101]
exact_synonym: "CG3411" [FlyBase:FBgn0004101]
exact_synonym: "D-SRF" [FlyBase:FBgn0004101]
exact_synonym: "DmSRF" [FlyBase:FBgn0004101]
exact_synonym: "dSRF" [UniProt:Q24535, FlyBase:FBgn0004101]
exact_synonym: "DSRF" [FlyBase:FBgn0004101]
exact_synonym: "DSrf" [FlyBase:FBgn0004101]
exact_synonym: "dsrf" [FlyBase:FBgn0004101]
exact_synonym: "DSrf/bs" [FlyBase:FBgn0004101]
exact_synonym: "Group IIc" [FlyBase:FBgn0004101]
exact_synonym: "l(2)03267" [FlyBase:FBgn0004101]
exact_synonym: "Protein blistered" [UniProt:Q24535]
exact_synonym: "pruned" [FlyBase:FBgn0004101]
exact_synonym: "pruned/DSRF" [FlyBase:FBgn0004101]
exact_synonym: "px" [FlyBase:FBgn0004101]
exact_synonym: "Serf" [UniProt:Q24535, FlyBase:FBgn0004101]
exact_synonym: "serum response factor" [FlyBase:FBgn0004101]
exact_synonym: "Serum response factor" [FlyBase:FBgn0004101]
exact_synonym: "Serum Response Factor" [FlyBase:FBgn0004101]
exact_synonym: "Serum response factor homolog" [UniProt:Q24535]
exact_synonym: "Srf" [FlyBase:FBgn0004101]
exact_synonym: "SRF" [FlyBase:FBgn0004101]
xref_analog: UniProt:Q24535
relationship: sequence_of IMR:0002996 ! SRF

[Term]
id: IMR:0003000
name: GAP1_CAEEL
def: "GAP-1 is most similar to the GAP-1 and GAP-1m RAS GTPase activating proteins in Drosophila and vertebrates, respectively." [PubMed:12648474, PubMed:9334333]
exact_synonym: "gap-1" [UniProt:Q22720]
exact_synonym: "GTPase-activating protein 1" [UniProt:Q22720]
exact_synonym: "Ras GTPase-activating protein gap-1" [UniProt:Q22720]
xref_analog: UniProt:Q22720
relationship: sequence_of IMR:0000443 ! Ras GAP

[Term]
id: IMR:0003001
name: LET23_CAEEL
def: "let-23 encodes a tyrosine kinase of the EGF receptor subfamily." [PubMed:1979659]
exact_synonym: "EC 2.7.10.1" [UniProt:P24348]
exact_synonym: "kin-7" [UniProt:P24348]
exact_synonym: "let-23" [UniProt:P24348]
exact_synonym: "Lethal protein 23" [UniProt:P24348]
exact_synonym: "Receptor tyrosine-protein kinase let-23" [UniProt:P24348]
xref_analog: UniProt:P24348
relationship: sequence_of IMR:0000081 ! EGFR

[Term]
id: IMR:0003002
name: LET60_CAEEL
def: "let-60 is very similar to ras gene products of other organisms." [PubMed:2257629]
exact_synonym: "Abnormal cell lineage protein 34" [UniProt:P22981]
exact_synonym: "let-60" [UniProt:P22981]
exact_synonym: "Lethal protein 60" [UniProt:P22981]
exact_synonym: "lin-34" [UniProt:P22981]
exact_synonym: "Ras protein let-60" [UniProt:P22981]
xref_analog: UniProt:P22981
relationship: sequence_of IMR:0000290 ! Ras

[Term]
id: IMR:0003003
name: Q965J5_CAEEL
def: "lin-1 encodes an ETS-domain transcription factor. The LIN-1 ETS domain is most similar to the Elk-I/SAP-I/Net subfamily of ETS domains." [PubMed:8543158]
exact_synonym: "Abnormal cell lineage protein 1" [UniProt:Q965J5]
exact_synonym: "LIN-1" [UniProt:Q965J5]
exact_synonym: "lin-1" [UniProt:Q965J5]
xref_analog: UniProt:Q965J5
relationship: sequence_of IMR:0000397 ! ets

[Term]
id: IMR:0003004
name: LIN3_CAEEL
def: "The lin-3 gene encodes a molecule similar to epidermal growth factor and to transforming growth factor-a and acts through the epidermal growth factor receptor homologue let-23." [PubMed:1641037]
exact_synonym: "Abnormal cell lineage protein 3" [UniProt:Q03345]
exact_synonym: "let-94" [UniProt:Q03345]
exact_synonym: "Lethal protein 94" [UniProt:Q03345]
exact_synonym: "lin-3" [UniProt:Q03345]
exact_synonym: "Protein lin-3" [UniProt:Q03345]
xref_analog: UniProt:Q03345
relationship: sequence_of IMR:0000047 ! EGF family

[Term]
id: IMR:0003005
name: MEK2_CAEEL
def: "The C. elegans mek-2 gene encodes a protein that is homologous to mammalian MAP kinase kinases. 54% of the amino acids in the mek-2 gene product are identical to human MEK1, and 55% of them are identical to the Drosophila MEK homolog Dsor-1." [PubMed:7729690]
exact_synonym: "Dual specificity mitogen-activated protein kinase kinase mek-2" [UniProt:Q10664]
exact_synonym: "EC 2.7.12.2" [UniProt:Q10664]
exact_synonym: "MAP kinase kinase mek-2" [UniProt:Q10664]
exact_synonym: "mek-2" [UniProt:Q10664]
xref_analog: UniProt:Q10664
relationship: sequence_of IMR:0000261 ! MEK1/2(MKK1/2)

[Term]
id: IMR:0003006
name: SUR1_CAEEL
def: "The sur-1 gene encodes a protein similar in overall structure to mammalian MAP kinases (ERKs)." [PubMed:8299935]
exact_synonym: "EC 2.7.11.24" [UniProt:P39745]
exact_synonym: "MAP kinase sur-1" [UniProt:P39745]
exact_synonym: "Mitogen-activated protein kinase mpk-1" [UniProt:P39745]
exact_synonym: "mpk-1" [UniProt:P39745]
exact_synonym: "sur-1" [UniProt:P39745]
xref_analog: UniProt:P39745
relationship: sequence_of IMR:0000227 ! ERK1/2

[Term]
id: IMR:0003007
name: Q9N5D3_CAEEL
def: "The C.elegans SOS-1 encodes a Sos homolog." [PubMed:10880441]
exact_synonym: "Drosophila sos homolog protein 1" [UniProt:Q9N5D3]
exact_synonym: "sos-1" [UniProt:Q9N5D3]
xref_analog: UniProt:Q9N5D3
relationship: sequence_of IMR:0000435 ! Sos

[Term]
id: IMR:0003008
name: EGL15_CAEEL
def: "egl-15 encodes a receptor tyrosine kinase of the fibroblast growth factor receptor (FGFR) ." [PubMed:7585964]
exact_synonym: "EC 2.7.10.1" [UniProt:Q10656]
exact_synonym: "Egg-laying defective protein 15" [UniProt:Q10656]
exact_synonym: "egl-15" [UniProt:Q10656]
exact_synonym: "Myoblast growth factor receptor egl-15" [UniProt:Q10656]
xref_analog: UniProt:Q10656
relationship: sequence_of IMR:0000080 ! FGFR

[Term]
id: IMR:0003009
name: Q9Y042_CAEEL
def: "egl-17 is a member of the fibroblast growth factor (FGF) family." [PubMed:9122212]
exact_synonym: "Egg laying defective protein 17" [UniProt:Q9Y042]
exact_synonym: "egl-17" [UniProt:Q9Y042]
exact_synonym: "EGL-17" [UniProt:Q9Y042]
xref_analog: UniProt:Q9Y042
relationship: sequence_of IMR:0000049 ! FGF

[Term]
id: IMR:0003010
name: O76282_CAEEL
def: "The Caenorhabditis elegans protein CLR-1 (CLeaR) is a receptor tyrosine phosphatase (RTP) with a complex extracellular region and two intracellular phosphatase domains." [PubMed:9585503]
exact_synonym: "CLR-1" [UniProt:O76282]
exact_synonym: "clr-1" [UniProt:O76282]
xref_analog: UniProt:O76282
relationship: sequence_of IMR:0000062 ! receptor protein-tyrosine phosphatase

[Term]
id: IMR:0003011
name: Su(fu)
def: "Suppressor of fused (Sufu) is a negative regulator of Hh signaling." [PubMed:19055941]
exact_synonym: "Sufu" []
exact_synonym: "suppressor of fused" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0003012
name: SUFU_HUMAN
exact_synonym: "PRO1280" [HGNC:16466, EntrezGene:51684]
exact_synonym: "SUFU" [HGNC:16466, UniProt:Q9UMX1, EntrezGene:51684, MIM:607035]
exact_synonym: "SUFUH" [HGNC:16466, UniProt:Q9UMX1, EntrezGene:51684, MIM:607035]
exact_synonym: "SUFUXL" [HGNC:16466, EntrezGene:51684]
exact_synonym: "Suppressor of fused homolog" [UniProt:Q9UMX1]
exact_synonym: "suppressor of fused homolog (Drosophila)" [HGNC:16466, EntrezGene:51684]
exact_synonym: "SUPPRESSOR OF FUSED, DROSOPHILA, HOMOLOG OF" [MIM:607035]
xref_analog: UniProt:Q9UMX1
relationship: sequence_of IMR:0003011 ! Su(fu)

[Term]
id: IMR:0003013
name: SUFU_MOUSE
exact_synonym: "Su(Fu)" [MGI:1345643]
exact_synonym: "Sufu" [UniProt:Q9Z0P7, MGI:1345643]
exact_synonym: "Suppressor of fused homolog" [UniProt:Q9Z0P7]
exact_synonym: "suppressor of fused homolog (Drosophila)" [MGI:1345643]
xref_analog: UniProt:Q9Z0P7
relationship: sequence_of IMR:0003011 ! Su(fu)

[Term]
id: IMR:0003014
name: Kif3A
is_a: IMR:0100193 ! kinesin-like protein

[Term]
id: IMR:0003015
name: MAD_DROME
exact_synonym: "2/23" [FlyBase:FBgn0011648]
exact_synonym: "apang" [FlyBase:FBgn0011648]
exact_synonym: "apg" [FlyBase:FBgn0011648]
exact_synonym: "CG12399" [FlyBase:FBgn0011648]
exact_synonym: "E(zen)2" [FlyBase:FBgn0011648]
exact_synonym: "En(vvl)" [FlyBase:FBgn0011648]
exact_synonym: "l(2)k00237" [FlyBase:FBgn0011648]
exact_synonym: "l(2)K00237" [FlyBase:FBgn0011648]
exact_synonym: "Mad" [UniProt:P42003, FlyBase:FBgn0011648]
exact_synonym: "MAD" [FlyBase:FBgn0011648]
exact_synonym: "mad" [FlyBase:FBgn0011648]
exact_synonym: "Mothers against dpp" [FlyBase:FBgn0011648]
exact_synonym: "p-Mad" [FlyBase:FBgn0011648]
exact_synonym: "pMad" [FlyBase:FBgn0011648]
exact_synonym: "pMAD" [FlyBase:FBgn0011648]
exact_synonym: "Protein mothers against dpp" [UniProt:P42003]
xref_analog: UniProt:P42003
relationship: sequence_of IMR:0000371 ! R-Smad

[Term]
id: IMR:0003016
name: Q95SI0_DROME
exact_synonym: "Activin-A-receptor-25D" [FlyBase:FBgn0003716]
exact_synonym: "Atkv" [FlyBase:FBgn0003716]
exact_synonym: "Atr25D" [FlyBase:FBgn0003716]
exact_synonym: "BMP receptor kinase 25D" [FlyBase:FBgn0003716]
exact_synonym: "Brk25D" [FlyBase:FBgn0003716]
exact_synonym: "Brk25D1" [FlyBase:FBgn0003716]
exact_synonym: "Brk25D2" [FlyBase:FBgn0003716]
exact_synonym: "CG14026" [FlyBase:FBgn0003716]
exact_synonym: "Dtfr" [FlyBase:FBgn0003716]
exact_synonym: "dtfr" [FlyBase:FBgn0003716]
exact_synonym: "GH25238p" [UniProt:Q95SI0]
exact_synonym: "l(2)04415" [FlyBase:FBgn0003716]
exact_synonym: "l(2)25Da" [FlyBase:FBgn0003716]
exact_synonym: "Receptor protein serine/threonine kinase" [UniProt:Q95SI0]
exact_synonym: "slater" [FlyBase:FBgn0003716]
exact_synonym: "STK-A" [FlyBase:FBgn0003716]
exact_synonym: "str" [FlyBase:FBgn0003716]
exact_synonym: "thick veins" [FlyBase:FBgn0003716]
exact_synonym: "thickvein" [FlyBase:FBgn0003716]
exact_synonym: "thickveins" [FlyBase:FBgn0003716]
exact_synonym: "Thickveins, isoform D" [UniProt:Q95SI0]
exact_synonym: "tkv" [UniProt:Q95SI0, FlyBase:FBgn0003716]
exact_synonym: "TKV" [FlyBase:FBgn0003716]
exact_synonym: "Tkv" [FlyBase:FBgn0003716]
exact_synonym: "TKV1" [UniProt:Q95SI0]
xref_analog: UniProt:Q95SI0
relationship: sequence_of IMR:0000093 ! TGF-beta receptor type I

[Term]
id: IMR:0003017
name: Q24468_DROME
exact_synonym: "Act-r" [FlyBase:FBgn0003169]
exact_synonym: "activin receptor" [FlyBase:FBgn0003169]
exact_synonym: "activin receptor type II" [FlyBase:FBgn0003169]
exact_synonym: "Activin-A-receptor-88CD" [FlyBase:FBgn0003169]
exact_synonym: "Atr" [FlyBase:FBgn0003169]
exact_synonym: "Atr-II" [FlyBase:FBgn0003169]
exact_synonym: "Atr88CD" [FlyBase:FBgn0003169]
exact_synonym: "AtrII" [FlyBase:FBgn0003169]
exact_synonym: "atrII" [FlyBase:FBgn0003169]
exact_synonym: "CG7904" [FlyBase:FBgn0003169]
exact_synonym: "dlhC" [FlyBase:FBgn0003169]
exact_synonym: "dorsal holes C" [FlyBase:FBgn0003169]
exact_synonym: "l(3)10460" [FlyBase:FBgn0003169]
exact_synonym: "l(3)j5A5" [FlyBase:FBgn0003169]
exact_synonym: "pun" [FlyBase:FBgn0003169]
exact_synonym: "Punt" [UniProt:Q24468, FlyBase:FBgn0003169]
exact_synonym: "punt" [FlyBase:FBgn0003169]
exact_synonym: "Punt receptor serine/threonine kinase" [UniProt:Q24468]
exact_synonym: "put" [UniProt:Q24468, FlyBase:FBgn0003169]
exact_synonym: "STK-C" [FlyBase:FBgn0003169]
exact_synonym: "TGF-B" [FlyBase:FBgn0003169]
exact_synonym: "TGF-beta" [FlyBase:FBgn0003169]
exact_synonym: "TGF-beta-type-receptor-like" [FlyBase:FBgn0003169]
exact_synonym: "Tgf-r" [FlyBase:FBgn0003169]
xref_analog: UniProt:Q24468
relationship: sequence_of IMR:0000094 ! TGF-beta receptor type II

[Term]
id: IMR:0003018
name: SCW_DROME
exact_synonym: "BcDNA:LD30945" [FlyBase:FBgn0005590]
exact_synonym: "CG31695" [FlyBase:FBgn0005590]
exact_synonym: "l(2)37Ff" [FlyBase:FBgn0005590]
exact_synonym: "l(2)IG76" [FlyBase:FBgn0005590]
exact_synonym: "Protein screw" [UniProt:P54631]
exact_synonym: "screw" [FlyBase:FBgn0005590]
exact_synonym: "scw" [UniProt:P54631, FlyBase:FBgn0005590]
exact_synonym: "Scw" [FlyBase:FBgn0005590]
xref_analog: UniProt:P54631
relationship: sequence_of IMR:0000040 ! BMP family

[Term]
id: IMR:0003019
name: Q7JPM7_DROME
exact_synonym: "Bkr43E" [FlyBase:FBgn0003317]
exact_synonym: "Brk43E" [FlyBase:FBgn0003317]
exact_synonym: "CG1891" [FlyBase:FBgn0003317]
exact_synonym: "SAX" [UniProt:Q7JPM7]
exact_synonym: "sax" [FlyBase:FBgn0003317, UniProt:Q7JPM7]
exact_synonym: "Sax" [FlyBase:FBgn0003317]
exact_synonym: "saxophone" [FlyBase:FBgn0003317]
exact_synonym: "STK-B" [FlyBase:FBgn0003317]
xref_analog: UniProt:Q7JPM7
relationship: sequence_of IMR:0000093 ! TGF-beta receptor type I

[Term]
id: IMR:0003020
name: TSG_DROME
exact_synonym: "CG1502" [FlyBase:FBgn0003865]
exact_synonym: "dTsg" [FlyBase:FBgn0003865]
exact_synonym: "l(1)11Ab" [FlyBase:FBgn0003865]
exact_synonym: "l(1)11Ac" [FlyBase:FBgn0003865]
exact_synonym: "l(1)RF32" [FlyBase:FBgn0003865]
exact_synonym: "l(1)tsg" [FlyBase:FBgn0003865]
exact_synonym: "lethal(1)11Ac" [FlyBase:FBgn0003865]
exact_synonym: "Protein twisted gastrulation" [UniProt:P54356]
exact_synonym: "RF32" [FlyBase:FBgn0003865]
exact_synonym: "tsg" [FlyBase:FBgn0003865, UniProt:P54356]
exact_synonym: "twisted gastrulation" [FlyBase:FBgn0003865]
xref_analog: UniProt:P54356
relationship: sequence_of IMR:0003034 ! Tsg

[Term]
id: IMR:0003021
name: SOG_DROME
exact_synonym: "CG9224" [FlyBase:FBgn0003463]
exact_synonym: "Dorsal-ventral patterning protein Sog" [UniProt:Q24025]
exact_synonym: "l(1)G0160" [FlyBase:FBgn0003463]
exact_synonym: "l(1)G0395" [FlyBase:FBgn0003463]
exact_synonym: "l(1)G0479" [FlyBase:FBgn0003463]
exact_synonym: "short gastrulation" [FlyBase:FBgn0003463]
exact_synonym: "Short gastrulation protein" [UniProt:Q24025]
exact_synonym: "sog" [UniProt:Q24025, FlyBase:FBgn0003463]
exact_synonym: "Sog" [FlyBase:FBgn0003463]
xref_analog: UniProt:Q24025
relationship: sequence_of IMR:0003038 ! chordin

[Term]
id: IMR:0003022
name: TLD_DROME
exact_synonym: "CG6868" [FlyBase:FBgn0003719]
exact_synonym: "CT21278" [FlyBase:FBgn0003719]
exact_synonym: "Dorsal-ventral patterning protein tolloid" [UniProt:P25723]
exact_synonym: "EC 3.4.24.-" [UniProt:P25723]
exact_synonym: "tld" [UniProt:P25723, FlyBase:FBgn0003719]
exact_synonym: "Tld" [FlyBase:FBgn0003719]
exact_synonym: "Tolloid" [FlyBase:FBgn0003719]
exact_synonym: "tolloid" [FlyBase:FBgn0003719]
xref_analog: UniProt:P25723
relationship: sequence_of IMR:0003045 ! BMP-1/TLD family

[Term]
id: IMR:0003023
name: O62609_DROME
exact_synonym: "anon-EST:Posey121" [FlyBase:FBgn0011655]
exact_synonym: "CG1775" [FlyBase:FBgn0011655]
exact_synonym: "dSmad4" [FlyBase:FBgn0011655]
exact_synonym: "E(zen)3" [FlyBase:FBgn0011655]
exact_synonym: "l(3)11m-254" [FlyBase:FBgn0011655]
exact_synonym: "l(3)12m-137" [FlyBase:FBgn0011655]
exact_synonym: "l(3)SG36" [FlyBase:FBgn0011655]
exact_synonym: "l(3)SG70" [FlyBase:FBgn0011655]
exact_synonym: "l(3)XIIm137" [FlyBase:FBgn0011655]
exact_synonym: "LD22279p" [UniProt:O62609]
exact_synonym: "lethal(3)SG36" [FlyBase:FBgn0011655]
exact_synonym: "lethal(3)SG70" [FlyBase:FBgn0011655]
exact_synonym: "Maternal effect enhancer of dpp" [UniProt:O62609]
exact_synonym: "Med" [UniProt:O62609, FlyBase:FBgn0011655]
exact_synonym: "med" [FlyBase:FBgn0011655]
exact_synonym: "Medea" [UniProt:O62609, FlyBase:FBgn0011655]
exact_synonym: "medea" [FlyBase:FBgn0011655]
exact_synonym: "Medea, isoform A" [UniProt:O62609]
xref_analog: UniProt:O62609
relationship: sequence_of IMR:0000372 ! Co-Smad

[Term]
id: IMR:0003024
name: PNR_DROME
exact_synonym: "CG3978" [FlyBase:FBgn0003117]
exact_synonym: "dGATA-A" [UniProt:P52168]
exact_synonym: "dGATAa" [FlyBase:FBgn0003117]
exact_synonym: "dGATAa/pannier" [FlyBase:FBgn0003117]
exact_synonym: "GATA" [FlyBase:FBgn0003117]
exact_synonym: "GATA-A" [UniProt:P52168]
exact_synonym: "GATA-binding factor A" [UniProt:P52168]
exact_synonym: "GATAa" [FlyBase:FBgn0003117]
exact_synonym: "GATAa/Pannier" [FlyBase:FBgn0003117]
exact_synonym: "l(3)89B3" [FlyBase:FBgn0003117]
exact_synonym: "pannier" [FlyBase:FBgn0003117]
exact_synonym: "pnr" [FlyBase:FBgn0003117, UniProt:P52168]
exact_synonym: "Pnr" [FlyBase:FBgn0003117]
exact_synonym: "prn" [FlyBase:FBgn0003117]
exact_synonym: "Protein pannier" [UniProt:P52168]
exact_synonym: "Transcription factor GATA-A" [UniProt:P52168]
xref_analog: UniProt:P52168
relationship: sequence_of IMR:0000410 ! GATA

[Term]
id: IMR:0003025
name: ACE_DROME
exact_synonym: "ACE" [FlyBase:FBgn0012037]
exact_synonym: "Ance" [FlyBase:FBgn0012037, UniProt:Q10714]
exact_synonym: "AnCE" [FlyBase:FBgn0012037]
exact_synonym: "Angiotensin converting enzyme" [FlyBase:FBgn0012037]
exact_synonym: "Angiotensin-converting enzyme" [UniProt:Q10714]
exact_synonym: "anon-EST:fe3D10" [FlyBase:FBgn0012037]
exact_synonym: "anon-fast-evolving-3D10" [FlyBase:FBgn0012037]
exact_synonym: "BG:DS08220.3" [FlyBase:FBgn0012037]
exact_synonym: "br31" [FlyBase:FBgn0012037]
exact_synonym: "CG8827" [FlyBase:FBgn0012037]
exact_synonym: "Dipeptidyl carboxypeptidase I" [UniProt:Q10714]
exact_synonym: "EC 3.4.15.1" [UniProt:Q10714]
exact_synonym: "Kininase II" [UniProt:Q10714]
exact_synonym: "l(2)34Eb" [FlyBase:FBgn0012037]
exact_synonym: "l(2)br31" [FlyBase:FBgn0012037]
exact_synonym: "l34Eb" [FlyBase:FBgn0012037]
exact_synonym: "Race" [FlyBase:FBgn0012037, UniProt:Q10714]
exact_synonym: "race" [FlyBase:FBgn0012037]
exact_synonym: "RACE" [FlyBase:FBgn0012037]
exact_synonym: "Related to angiotensin converting enzyme" [FlyBase:FBgn0012037]
xref_analog: UniProt:Q10714
relationship: sequence_of IMR:0000304 ! protease

[Term]
id: IMR:0003026
name: alpha PIX
is_a: IMR:0001954 ! RhoGEF

[Term]
id: IMR:0003027
name: ARHG6_HUMAN
exact_synonym: "Alpha-Pix" [MIM:300267, UniProt:Q15052]
exact_synonym: "alpha-PIX" [EntrezGene:9459, HGNC:685]
exact_synonym: "alphaPIX" [EntrezGene:9459, HGNC:685]
exact_synonym: "ARHGEF6" [MIM:300267, UniProt:Q15052, EntrezGene:9459, HGNC:685]
exact_synonym: "COOL-2" [UniProt:Q15052]
exact_synonym: "Cool-2" [EntrezGene:9459, HGNC:685]
exact_synonym: "COOL2" [MIM:300267, UniProt:Q15052, EntrezGene:9459]
exact_synonym: "Cool2" [HGNC:685]
exact_synonym: "KIAA0006" [UniProt:Q15052, EntrezGene:9459, HGNC:685]
exact_synonym: "MRX46" [EntrezGene:9459]
exact_synonym: "PAK-interacting exchange factor alpha" [UniProt:Q15052]
exact_synonym: "PAK-INTERACTING EXCHANGE FACTOR, ALPHA" [MIM:300267]
exact_synonym: "PIXA" [MIM:300267, UniProt:Q15052, EntrezGene:9459]
exact_synonym: "Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6" [EntrezGene:9459, HGNC:685]
exact_synonym: "Rac/Cdc42 guanine nucleotide exchange factor 6" [UniProt:Q15052]
exact_synonym: "Rho guanine nucleotide exchange factor 6" [MIM:300267, UniProt:Q15052]
xref_analog: UniProt:Q15052
relationship: sequence_of IMR:0003026 ! alpha PIX

[Term]
id: IMR:0003028
name: Q5U110_DROME
exact_synonym: "1883" [FlyBase:FBgn0020493]
exact_synonym: "anon-EST:fe1F5" [FlyBase:FBgn0020493]
exact_synonym: "anon-fast-evolving-1F5" [FlyBase:FBgn0020493]
exact_synonym: "CG5201" [FlyBase:FBgn0020493]
exact_synonym: "Dad" [FlyBase:FBgn0020493, UniProt:Q5U110]
exact_synonym: "dad" [FlyBase:FBgn0020493]
exact_synonym: "DAD" [FlyBase:FBgn0020493]
exact_synonym: "Dad1" [FlyBase:FBgn0020493]
exact_synonym: "daughters against dpp" [FlyBase:FBgn0020493]
exact_synonym: "Daughters against dpp" [FlyBase:FBgn0020493]
exact_synonym: "Daughters against dpp, isoform A" [UniProt:Q5U110]
exact_synonym: "Daughters against dpp, isoform B" [UniProt:Q5U110]
exact_synonym: "Daughters against dpp, isoform C" [UniProt:Q5U110]
exact_synonym: "EP(3)3196" [FlyBase:FBgn0020493]
exact_synonym: "EP3196" [FlyBase:FBgn0020493]
exact_synonym: "l(3)j1E4" [FlyBase:FBgn0020493]
exact_synonym: "LD47465p" [UniProt:Q5U110]
xref_analog: UniProt:Q5U110
relationship: sequence_of IMR:0000373 ! I-Smad

[Term]
id: IMR:0003029
name: VG_DROME
exact_synonym: "CG3830" [FlyBase:FBgn0003975]
exact_synonym: "Protein vestigial" [UniProt:Q26366]
exact_synonym: "vestigial" [FlyBase:FBgn0003975]
exact_synonym: "vg" [UniProt:Q26366, FlyBase:FBgn0003975]
exact_synonym: "Vg" [FlyBase:FBgn0003975]
exact_synonym: "VG" [FlyBase:FBgn0003975]
exact_synonym: "vg21" [FlyBase:FBgn0003975]
xref_analog: UniProt:Q26366
relationship: sequence_of IMR:0000424 ! transcriptional co-activator

[Term]
id: IMR:0003030
name: OMB_DROME
exact_synonym: "bi" [UniProt:Q24432, FlyBase:FBgn0000179]
exact_synonym: "BI" [FlyBase:FBgn0000179]
exact_synonym: "bifid" [FlyBase:FBgn0000179]
exact_synonym: "CG3578" [FlyBase:FBgn0000179]
exact_synonym: "Dm-OMB" [FlyBase:FBgn0000179]
exact_synonym: "dm-omb" [FlyBase:FBgn0000179]
exact_synonym: "Dm-omb" [FlyBase:FBgn0000179]
exact_synonym: "l(1)bi" [FlyBase:FBgn0000179]
exact_synonym: "L(1)omb" [UniProt:Q24432]
exact_synonym: "l(1)omb" [FlyBase:FBgn0000179]
exact_synonym: "Lethal(1)optomotor-blind" [UniProt:Q24432]
exact_synonym: "OMB" [UniProt:Q24432, FlyBase:FBgn0000179]
exact_synonym: "omb" [FlyBase:FBgn0000179]
exact_synonym: "Omb" [FlyBase:FBgn0000179]
exact_synonym: "optomoter blind" [FlyBase:FBgn0000179]
exact_synonym: "optomotor blind" [FlyBase:FBgn0000179]
exact_synonym: "Optomotor blind" [FlyBase:FBgn0000179]
exact_synonym: "optomotor-blind" [FlyBase:FBgn0000179]
exact_synonym: "Optomotor-blind" [FlyBase:FBgn0000179]
exact_synonym: "optomotor-blind gene" [FlyBase:FBgn0000179]
exact_synonym: "Optomotor-blind protein" [UniProt:Q24432]
exact_synonym: "optomotorblind" [FlyBase:FBgn0000179]
exact_synonym: "Protein bifid" [UniProt:Q24432]
exact_synonym: "Qd" [FlyBase:FBgn0000179]
exact_synonym: "Quadroon" [FlyBase:FBgn0000179]
exact_synonym: "T3" [FlyBase:FBgn0000179]
xref_analog: UniProt:Q24432
relationship: sequence_of IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0003031
name: SALM_DROME
exact_synonym: "3602" [FlyBase:FBgn0261648]
exact_synonym: "CG6464" [FlyBase:FBgn0261648]
exact_synonym: "Homeotic protein spalt-major" [UniProt:P39770]
exact_synonym: "l(2)03602" [FlyBase:FBgn0261648]
exact_synonym: "sal" [FlyBase:FBgn0261648, UniProt:P39770]
exact_synonym: "Sal" [FlyBase:FBgn0261648]
exact_synonym: "sal major" [FlyBase:FBgn0261648]
exact_synonym: "salII" [FlyBase:FBgn0261648]
exact_synonym: "salm" [FlyBase:FBgn0261648, UniProt:P39770]
exact_synonym: "salM" [FlyBase:FBgn0261648]
exact_synonym: "SalM" [FlyBase:FBgn0261648]
exact_synonym: "spalt" [FlyBase:FBgn0261648]
exact_synonym: "SPALT" [FlyBase:FBgn0261648]
exact_synonym: "Spalt" [FlyBase:FBgn0261648]
exact_synonym: "spalt major" [FlyBase:FBgn0261648]
exact_synonym: "spalt-major" [FlyBase:FBgn0261648]
xref_analog: UniProt:P39770
relationship: sequence_of IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0003032
name: ARHG6_MOUSE
exact_synonym: "alpha-PIX" [MGI:1920591]
exact_synonym: "Arhgef6" [UniProt:Q8K4I3, MGI:1920591]
exact_synonym: "Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6" [MGI:1920591]
exact_synonym: "Rac/Cdc42 guanine nucleotide exchange factor 6" [UniProt:Q8K4I3]
exact_synonym: "Rho guanine nucleotide exchange factor 6" [UniProt:Q8K4I3]
xref_analog: UniProt:Q8K4I3
relationship: sequence_of IMR:0003026 ! alpha PIX

[Term]
id: IMR:0003033
name: ARHG6_RAT
exact_synonym: "Arhgef6" [UniProt:Q5XXR3, RGD:1359674]
exact_synonym: "Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6" [RGD:1359674]
exact_synonym: "Rac/Cdc42 guanine nucleotide exchange factor 6" [UniProt:Q5XXR3]
exact_synonym: "Rho guanine nucleotide exchange factor 6" [UniProt:Q5XXR3]
xref_analog: UniProt:Q5XXR3
relationship: sequence_of IMR:0003026 ! alpha PIX

[Term]
id: IMR:0003034
name: Tsg
exact_synonym: "Twisted Gastrulation" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0003035
name: TWSG1_HUMAN
exact_synonym: "TSG" [EntrezGene:57045, HGNC:12429, MIM:605049, UniProt:Q9GZX9]
exact_synonym: "TWISTED GASTRULATION HOMOLOG 1" [MIM:605049]
exact_synonym: "twisted gastrulation homolog 1 (Drosophila)" [EntrezGene:57045, HGNC:12429]
exact_synonym: "Twisted gastrulation protein homolog 1" [UniProt:Q9GZX9]
exact_synonym: "TWSG1" [EntrezGene:57045, HGNC:12429, MIM:605049, UniProt:Q9GZX9]
xref_analog: UniProt:Q9GZX9
relationship: sequence_of IMR:0003034 ! Tsg

[Term]
id: IMR:0003036
name: TWSG1_MOUSE
exact_synonym: "D17Ertd403e" [MGI:2137520]
exact_synonym: "Tsg" [UniProt:Q9EP52, MGI:2137520]
exact_synonym: "twisted gastrulation homolog 1 (Drosophila)" [MGI:2137520]
exact_synonym: "Twisted gastrulation protein homolog 1" [UniProt:Q9EP52]
exact_synonym: "Twsg1" [UniProt:Q9EP52, MGI:2137520]
xref_analog: UniProt:Q9EP52
relationship: sequence_of IMR:0003034 ! Tsg

[Term]
id: IMR:0003037
name: D4A9T2_RAT
exact_synonym: "twisted gastrulation homolog 1 (Drosophila)" [RGD:1311215]
exact_synonym: "Twisted gastrulation homolog 1 (Drosophila) (Predicted), isoform CRA_b" [UniProt:D4A9T2]
exact_synonym: "Twsg1" [RGD:1311215, UniProt:D4A9T2]
exact_synonym: "Twsg1_predicted" [UniProt:D4A9T2]
exact_synonym: "Uncharacterized protein" [UniProt:D4A9T2]
xref_analog: UniProt:D4A9T2
relationship: sequence_of IMR:0003034 ! Tsg

[Term]
id: IMR:0003038
name: chordin
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0003039
name: CHRD_HUMAN
exact_synonym: "Chordin" [UniProt:Q9H2X0, MIM:603475]
exact_synonym: "chordin" [HGNC:1949, EntrezGene:8646]
exact_synonym: "CHRD" [HGNC:1949, EntrezGene:8646, UniProt:Q9H2X0, MIM:603475]
exact_synonym: "MGC133038" [EntrezGene:8646]
xref_analog: UniProt:Q9H2X0
relationship: sequence_of IMR:0003038 ! chordin

[Term]
id: IMR:0003040
name: CHRD_MOUSE
exact_synonym: "Chd" [MGI:1313268]
exact_synonym: "Chordin" [UniProt:Q9Z0E2]
exact_synonym: "chordin" [MGI:1313268]
exact_synonym: "Chrd" [MGI:1313268, UniProt:Q9Z0E2]
xref_analog: UniProt:Q9Z0E2
relationship: sequence_of IMR:0003038 ! chordin

[Term]
id: IMR:0003041
name: CHRD_RAT
exact_synonym: "Chordin" [UniProt:Q63148]
exact_synonym: "chordin" [RGD:620181]
exact_synonym: "Chrd" [UniProt:Q63148, RGD:620181]
xref_analog: UniProt:Q63148
relationship: sequence_of IMR:0003038 ! chordin

[Term]
id: IMR:0003042
name: CHRD_XENLA
exact_synonym: "Chordin" [UniProt:Q91713]
exact_synonym: "chrd" [UniProt:Q91713]
exact_synonym: "Organizer-specific secreted-dorsalizing factor" [UniProt:Q91713]
xref_analog: UniProt:Q91713
relationship: sequence_of IMR:0003038 ! chordin

[Term]
id: IMR:0003043
name: TWS1A_XENLA
exact_synonym: "tsg" [UniProt:Q98T88]
exact_synonym: "Twisted gastrulation protein homolog 1-A" [UniProt:Q98T88]
exact_synonym: "twsg1-a" [UniProt:Q98T88]
xref_analog: UniProt:Q98T88
relationship: sequence_of IMR:0003034 ! Tsg

[Term]
id: IMR:0003044
name: TWS1B_XENLA
exact_synonym: "tsg" [UniProt:Q9I8M9]
exact_synonym: "Twisted gastrulation protein homolog 1-B" [UniProt:Q9I8M9]
exact_synonym: "twsg1-b" [UniProt:Q9I8M9]
xref_analog: UniProt:Q9I8M9
relationship: sequence_of IMR:0003034 ! Tsg

[Term]
id: IMR:0003045
name: BMP-1/TLD family
def: "The BMP-1/TLD metalloproteinases, conserved in species ranging from Drosophila to humans, act in dorsal-ventral patterning via activation of BMP2, BMP4 (vertebrates) and Dpp (arthropods).\n\nThere are four mammalian BMP-1/TLD-like proteinases, including BMP-1/mTLD, which is encoded by alternatively spliced mRNA produced by the Bmp1 gene, and TLL1 and TLL2, which are genetically distinct." [PubMed:17560775, PubMed:19429706]
exact_synonym: "bone morphogenetic protein-1/tolloid family" []
is_a: IMR:0000304 ! protease

[Term]
id: IMR:0003046
name: BMP1_HUMAN
exact_synonym: "BMP-1" [UniProt:P13497]
exact_synonym: "BMP1" [UniProt:P13497, MIM:112264, EntrezGene:649, HGNC:1067]
exact_synonym: "Bone morphogenetic protein 1" [UniProt:P13497, MIM:112264]
exact_synonym: "bone morphogenetic protein 1" [EntrezGene:649, HGNC:1067]
exact_synonym: "EC 3.4.24.19" [UniProt:P13497]
exact_synonym: "FLJ44432" [EntrezGene:649]
exact_synonym: "Mammalian tolloid protein" [UniProt:P13497]
exact_synonym: "mTld" [UniProt:P13497]
exact_synonym: "PCOLC" [UniProt:P13497, EntrezGene:649]
exact_synonym: "PCP" [UniProt:P13497, EntrezGene:649]
exact_synonym: "PCP2" [EntrezGene:649]
exact_synonym: "Procollagen C-proteinase" [UniProt:P13497, MIM:112264]
exact_synonym: "TLD" [MIM:112264, EntrezGene:649]
exact_synonym: "TOLLOID, DROSOPHILA, HOMOLOG OF" [MIM:112264]
xref_analog: UniProt:P13497
relationship: sequence_of IMR:0003045 ! BMP-1/TLD family

[Term]
id: IMR:0003047
name: BMP1_MOUSE
exact_synonym: "BMP-1" [UniProt:P98063]
exact_synonym: "Bmp1" [UniProt:P98063, MGI:88176]
exact_synonym: "Bone morphogenetic protein 1" [UniProt:P98063]
exact_synonym: "bone morphogenetic protein 1" [MGI:88176]
exact_synonym: "EC 3.4.24.19" [UniProt:P98063]
exact_synonym: "Mammalian tolloid protein" [UniProt:P98063]
exact_synonym: "mTld" [UniProt:P98063]
exact_synonym: "PCP" [UniProt:P98063]
exact_synonym: "Procollagen C-proteinase" [UniProt:P98063]
xref_analog: UniProt:P98063
relationship: sequence_of IMR:0003045 ! BMP-1/TLD family

[Term]
id: IMR:0003048
name: BMP1_XENLA
exact_synonym: "BMP-1" [UniProt:P98070]
exact_synonym: "bmp1" [UniProt:P98070]
exact_synonym: "Bone morphogenetic protein 1" [UniProt:P98070]
exact_synonym: "EC 3.4.24.-" [UniProt:P98070]
xref_analog: UniProt:P98070
relationship: sequence_of IMR:0003045 ! BMP-1/TLD family

[Term]
id: IMR:0003049
name: TLL1_HUMAN
exact_synonym: "ASD6" [EntrezGene:7092]
exact_synonym: "EC 3.4.24.-" [UniProt:O43897]
exact_synonym: "TLL" [EntrezGene:7092, UniProt:O43897, MIM:606742]
exact_synonym: "TLL1" [EntrezGene:7092, UniProt:O43897, MIM:606742, HGNC:11843]
exact_synonym: "tolloid-like 1" [EntrezGene:7092, MIM:606742, HGNC:11843]
exact_synonym: "Tolloid-like protein 1" [UniProt:O43897]
xref_analog: UniProt:O43897
relationship: sequence_of IMR:0003045 ! BMP-1/TLD family

[Term]
id: IMR:0003050
name: TLL1_MOUSE
exact_synonym: "EC 3.4.24.-" [UniProt:Q62381]
exact_synonym: "mTll" [UniProt:Q62381]
exact_synonym: "Tll" [UniProt:Q62381]
exact_synonym: "Tll-1" [MGI:106923]
exact_synonym: "Tll1" [UniProt:Q62381, MGI:106923]
exact_synonym: "tolloid-like" [MGI:106923]
exact_synonym: "Tolloid-like protein 1" [UniProt:Q62381]
xref_analog: UniProt:Q62381
relationship: sequence_of IMR:0003045 ! BMP-1/TLD family

[Term]
id: IMR:0003051
name: TLL1_XENLA
exact_synonym: "EC 3.4.24.-" [UniProt:Q8JI28]
exact_synonym: "Metalloprotease xolloid-like" [UniProt:Q8JI28]
exact_synonym: "tll1" [UniProt:Q8JI28]
exact_synonym: "Tolloid-like protein 1" [UniProt:Q8JI28]
exact_synonym: "Xenopus tolloid-like protein 1" [UniProt:Q8JI28]
exact_synonym: "xlr" [UniProt:Q8JI28]
exact_synonym: "Xlr" [UniProt:Q8JI28]
xref_analog: UniProt:Q8JI28
relationship: sequence_of IMR:0003045 ! BMP-1/TLD family

[Term]
id: IMR:0003052
name: TLL2_HUMAN
exact_synonym: "EC 3.4.24.-" [UniProt:Q9Y6L7]
exact_synonym: "KIAA0932" [EntrezGene:7093, MIM:606743, UniProt:Q9Y6L7]
exact_synonym: "MGC133312" [EntrezGene:7093]
exact_synonym: "MGC133313" [EntrezGene:7093]
exact_synonym: "TLL2" [EntrezGene:7093, HGNC:11844, MIM:606743, UniProt:Q9Y6L7]
exact_synonym: "tolloid-like 2" [EntrezGene:7093, HGNC:11844, MIM:606743]
exact_synonym: "Tolloid-like protein 2" [UniProt:Q9Y6L7]
xref_analog: UniProt:Q9Y6L7
relationship: sequence_of IMR:0003045 ! BMP-1/TLD family

[Term]
id: IMR:0003053
name: TLL2_MOUSE
exact_synonym: "EC 3.4.24.-" [UniProt:Q9WVM6]
exact_synonym: "Tll2" [MGI:1346044, UniProt:Q9WVM6]
exact_synonym: "tolloid-like 2" [MGI:1346044]
exact_synonym: "Tolloid-like protein 2" [UniProt:Q9WVM6]
xref_analog: UniProt:Q9WVM6
relationship: sequence_of IMR:0003045 ! BMP-1/TLD family

[Term]
id: IMR:0003054
name: TLL2_XENLA
exact_synonym: "EC 3.4.24.-" [UniProt:O57382]
exact_synonym: "Metalloprotease xolloid" [UniProt:O57382]
exact_synonym: "tll2" [UniProt:O57382]
exact_synonym: "Tolloid-like protein 2" [UniProt:O57382]
exact_synonym: "Xenopus tolloid" [UniProt:O57382]
exact_synonym: "xld" [UniProt:O57382]
xref_analog: UniProt:O57382
relationship: sequence_of IMR:0003045 ! BMP-1/TLD family

[Term]
id: IMR:0003055
name: SMA2_CAEEL
exact_synonym: "cem-1" [UniProt:Q02330]
exact_synonym: "Dwarfin sma-2" [UniProt:Q02330]
exact_synonym: "MAD protein homolog 1" [UniProt:Q02330]
exact_synonym: "sma-2" [UniProt:Q02330]
xref_analog: UniProt:Q02330
relationship: sequence_of IMR:0000371 ! R-Smad

[Term]
id: IMR:0003056
name: SMA3_CAEEL
exact_synonym: "cem-2" [UniProt:P45896]
exact_synonym: "Dwarfin sma-3" [UniProt:P45896]
exact_synonym: "MAD protein homolog 2" [UniProt:P45896]
exact_synonym: "sma-3" [UniProt:P45896]
xref_analog: UniProt:P45896
relationship: sequence_of IMR:0000371 ! R-Smad

[Term]
id: IMR:0003057
name: SMA4_CAEEL
exact_synonym: "cem-3" [UniProt:P45897]
exact_synonym: "Dwarfin sma-4" [UniProt:P45897]
exact_synonym: "MAD protein homolog 3" [UniProt:P45897]
exact_synonym: "sma-4" [UniProt:P45897]
xref_analog: UniProt:P45897
relationship: sequence_of IMR:0000372 ! Co-Smad

[Term]
id: IMR:0003058
name: O96660_DROME
exact_synonym: "CG2262" [FlyBase:FBgn0025800]
exact_synonym: "dSMAD2" [FlyBase:FBgn0025800]
exact_synonym: "dSmad2" [FlyBase:FBgn0025800]
exact_synonym: "DSMAD2" [FlyBase:FBgn0025800]
exact_synonym: "l(1)G0348" [FlyBase:FBgn0025800]
exact_synonym: "LD15813p" [UniProt:O96660]
exact_synonym: "sad" [FlyBase:FBgn0025800]
exact_synonym: "Sad" [FlyBase:FBgn0025800]
exact_synonym: "sisters against dpp" [FlyBase:FBgn0025800]
exact_synonym: "Sisters against dpp" [FlyBase:FBgn0025800]
exact_synonym: "Smad on X" [FlyBase:FBgn0025800, UniProt:O96660]
exact_synonym: "smad2" [FlyBase:FBgn0025800, UniProt:O96660]
exact_synonym: "SMAD2" [FlyBase:FBgn0025800]
exact_synonym: "Smad2" [FlyBase:FBgn0025800]
exact_synonym: "Smox" [FlyBase:FBgn0025800, UniProt:O96660]
exact_synonym: "smox" [FlyBase:FBgn0025800]
exact_synonym: "ted" [FlyBase:FBgn0025800]
exact_synonym: "temporarily deranged" [FlyBase:FBgn0025800]
exact_synonym: "tmp" [FlyBase:FBgn0025800]
exact_synonym: "Transcription factor SMAD2" [UniProt:O96660]
xref_analog: UniProt:O96660
relationship: sequence_of IMR:0000371 ! R-Smad

[Term]
id: IMR:0003059
name: NODAL_XENLA
exact_synonym: "nodal" [UniProt:Q91619]
exact_synonym: "Nodal homolog" [UniProt:Q91619]
exact_synonym: "Nodal-related protein 1" [UniProt:Q91619]
exact_synonym: "nr-1" [UniProt:Q91619]
exact_synonym: "nr1" [UniProt:Q91619]
exact_synonym: "Xnr-1" [UniProt:Q91619]
exact_synonym: "Xnr1" [UniProt:Q91619]
xref_analog: UniProt:Q91619
relationship: sequence_of IMR:0000046 ! Nodal family

[Term]
id: IMR:0003060
name: NODAL_HUMAN
exact_synonym: "MGC138230" [EntrezGene:4838]
exact_synonym: "NODAL" [HGNC:7865, UniProt:Q96S42, MIM:601265, EntrezGene:4838]
exact_synonym: "Nodal homolog" [UniProt:Q96S42]
exact_synonym: "nodal homolog (mouse)" [HGNC:7865, EntrezGene:4838]
exact_synonym: "NODAL, MOUSE, HOMOLOG OF" [MIM:601265]
xref_analog: UniProt:Q96S42
relationship: sequence_of IMR:0000046 ! Nodal family

[Term]
id: IMR:0003061
name: NODAL_MOUSE
exact_synonym: "Nodal" [UniProt:P43021, MGI:97359]
exact_synonym: "nodal" [MGI:97359]
exact_synonym: "Tg.413d" [MGI:97359]
xref_analog: UniProt:P43021
relationship: sequence_of IMR:0000046 ! Nodal family

[Term]
id: IMR:0003062
name: GDF-5
exact_synonym: "cartilage-derived morphogenetic protein-1" []
exact_synonym: "CDMP-1" []
exact_synonym: "Growth/differentiation factor-5" []
is_a: IMR:0003085 ! GDF-5 subfamily

[Term]
id: IMR:0003063
name: GDF5_HUMAN
exact_synonym: "BMP14" [HGNC:4220, EntrezGene:8200]
exact_synonym: "Cartilage-derived morphogenetic protein 1" [UniProt:P43026, MIM:601146]
exact_synonym: "CDMP-1" [UniProt:P43026]
exact_synonym: "CDMP1" [HGNC:4220, EntrezGene:8200, UniProt:P43026, MIM:601146]
exact_synonym: "GDF-5" [UniProt:P43026]
exact_synonym: "GDF5" [HGNC:4220, EntrezGene:8200, UniProt:P43026, MIM:601146]
exact_synonym: "growth differentiation factor 5" [HGNC:4220, EntrezGene:8200]
exact_synonym: "Growth/differentiation factor 5" [UniProt:P43026, MIM:601146]
exact_synonym: "LAP4" [EntrezGene:8200, MIM:601146]
exact_synonym: "LIPOPOLYSACCHARIDE-ASSOCIATED PROTEIN 4" [MIM:601146]
exact_synonym: "LPS-ASSOCIATED PROTEIN 4" [MIM:601146]
exact_synonym: "OS5" [EntrezGene:8200]
exact_synonym: "Radotermin" [UniProt:P43026]
exact_synonym: "SYNS2" [EntrezGene:8200]
xref_analog: UniProt:P43026
relationship: sequence_of IMR:0003062 ! GDF-5

[Term]
id: IMR:0003064
name: GDF5_MOUSE
exact_synonym: "Bp" [UniProt:P43027]
exact_synonym: "bp" [MGI:95688]
exact_synonym: "brp" [MGI:95688]
exact_synonym: "cartilage-derived morphogenetic protein-1" [MGI:95688]
exact_synonym: "CDMP-1" [MGI:95688]
exact_synonym: "Gdf-5" [UniProt:P43027]
exact_synonym: "GDF-5" [UniProt:P43027]
exact_synonym: "Gdf5" [UniProt:P43027, MGI:95688]
exact_synonym: "growth differentiation factor 5" [MGI:95688]
exact_synonym: "Growth/differentiation factor 5" [UniProt:P43027]
xref_analog: UniProt:P43027
relationship: sequence_of IMR:0003062 ! GDF-5

[Term]
id: IMR:0003065
name: GDF-6
exact_synonym: "BMP-13" []
exact_synonym: "Bone morphogenetic protein-13" []
exact_synonym: "cartilage-derived morphogenetic protein-2" []
exact_synonym: "CDMP-2" []
exact_synonym: "Growth/differentiation factor 6" []
is_a: IMR:0003085 ! GDF-5 subfamily

[Term]
id: IMR:0003066
name: GDF6_HUMAN
exact_synonym: "BMP13" [EntrezGene:392255, HGNC:4221]
exact_synonym: "CARTILAGE-DERIVED MORPHOGENETIC PROTEIN 2" [MIM:601147]
exact_synonym: "CDMP2" [EntrezGene:392255, MIM:601147]
exact_synonym: "GDF-6" [UniProt:Q6KF10]
exact_synonym: "GDF16" [UniProt:Q6KF10]
exact_synonym: "GDF6" [EntrezGene:392255, HGNC:4221, MIM:601147, UniProt:Q6KF10]
exact_synonym: "growth differentiation factor 6" [EntrezGene:392255, HGNC:4221]
exact_synonym: "Growth/differentiation factor 16" [UniProt:Q6KF10]
exact_synonym: "Growth/differentiation factor 6" [MIM:601147, UniProt:Q6KF10]
exact_synonym: "KFS" [EntrezGene:392255]
exact_synonym: "KFS1" [EntrezGene:392255]
exact_synonym: "KFSL" [EntrezGene:392255]
exact_synonym: "MCOP4" [EntrezGene:392255]
exact_synonym: "MCOPCB6" [EntrezGene:392255]
exact_synonym: "MGC158100" [EntrezGene:392255]
exact_synonym: "MGC158101" [EntrezGene:392255]
exact_synonym: "SCDO4" [EntrezGene:392255]
exact_synonym: "SGM1" [EntrezGene:392255]
xref_analog: UniProt:Q6KF10
relationship: sequence_of IMR:0003065 ! GDF-6

[Term]
id: IMR:0003067
name: GDF6_MOUSE
exact_synonym: "BMP13" [MGI:95689]
exact_synonym: "GDF-6" [UniProt:P43028]
exact_synonym: "Gdf-6" [UniProt:P43028]
exact_synonym: "Gdf16" [UniProt:P43028]
exact_synonym: "Gdf6" [MGI:95689, UniProt:P43028]
exact_synonym: "growth differentiation factor 6" [MGI:95689]
exact_synonym: "Growth/differentiation factor 16" [UniProt:P43028]
exact_synonym: "Growth/differentiation factor 6" [UniProt:P43028]
xref_analog: UniProt:P43028
relationship: sequence_of IMR:0003065 ! GDF-6

[Term]
id: IMR:0003068
name: GDF6_RAT
exact_synonym: "GDF-6" [UniProt:Q6HA10]
exact_synonym: "Gdf16" [UniProt:Q6HA10]
exact_synonym: "Gdf6" [RGD:620104, UniProt:Q6HA10]
exact_synonym: "growth differentiation factor 6" [RGD:620104]
exact_synonym: "Growth/differentiation factor 16" [UniProt:Q6HA10]
exact_synonym: "Growth/differentiation factor 6" [UniProt:Q6HA10]
xref_analog: UniProt:Q6HA10
relationship: sequence_of IMR:0003065 ! GDF-6

[Term]
id: IMR:0003069
name: GDF-7
exact_synonym: "BMP-12" []
exact_synonym: "Bone morphogenetic protein-12" []
exact_synonym: "Growth/differentiation factor 7" []
is_a: IMR:0003085 ! GDF-5 subfamily

[Term]
id: IMR:0003070
name: GDF7_HUMAN
exact_synonym: "BMP12" [HGNC:4222, EntrezGene:151449]
exact_synonym: "GDF-7" [UniProt:Q7Z4P5]
exact_synonym: "GDF7" [HGNC:4222, EntrezGene:151449, UniProt:Q7Z4P5, MIM:604651]
exact_synonym: "growth differentiation factor 7" [HGNC:4222, EntrezGene:151449]
exact_synonym: "Growth/differentiation factor 7" [UniProt:Q7Z4P5, MIM:604651]
xref_analog: UniProt:Q7Z4P5
relationship: sequence_of IMR:0003069 ! GDF-7

[Term]
id: IMR:0003071
name: GDF7_MOUSE
exact_synonym: "BMP12" [MGI:95690]
exact_synonym: "Gdf-7" [UniProt:P43029]
exact_synonym: "GDF-7" [UniProt:P43029]
exact_synonym: "Gdf7" [MGI:95690, UniProt:P43029]
exact_synonym: "growth differentiation factor 7" [MGI:95690]
exact_synonym: "Growth/differentiation factor 7" [UniProt:P43029]
xref_analog: UniProt:P43029
relationship: sequence_of IMR:0003069 ! GDF-7

[Term]
id: IMR:0003072
name: 60A_DROME
exact_synonym: "60A" [FlyBase:FBgn0024234, UniProt:P27091]
exact_synonym: "CG5562" [FlyBase:FBgn0024234]
exact_synonym: "Dm-GBB" [FlyBase:FBgn0024234]
exact_synonym: "gbb" [FlyBase:FBgn0024234, UniProt:P27091]
exact_synonym: "Gbb" [FlyBase:FBgn0024234]
exact_synonym: "gbb-60A" [FlyBase:FBgn0024234, UniProt:P27091]
exact_synonym: "Gbb-60A" [FlyBase:FBgn0024234]
exact_synonym: "gcn" [FlyBase:FBgn0024234]
exact_synonym: "glass bottom boat" [FlyBase:FBgn0024234]
exact_synonym: "glass bottom boat-60A" [FlyBase:FBgn0024234]
exact_synonym: "l(2)60A-J" [FlyBase:FBgn0024234]
exact_synonym: "Protein 60A" [UniProt:P27091]
exact_synonym: "Protein glass bottom boat" [UniProt:P27091]
exact_synonym: "SixtyA" [FlyBase:FBgn0024234]
exact_synonym: "TGF-b" [FlyBase:FBgn0024234]
exact_synonym: "Tgfb-60" [FlyBase:FBgn0024234]
exact_synonym: "TGFb-60A" [UniProt:P27091]
exact_synonym: "tgfb-60A" [FlyBase:FBgn0024234]
exact_synonym: "TGFbeta-60A" [FlyBase:FBgn0024234]
exact_synonym: "Tgfbeta-60A" [FlyBase:FBgn0024234]
exact_synonym: "Transforming growth factor beta at 60A" [FlyBase:FBgn0024234]
exact_synonym: "vgr/60A" [FlyBase:FBgn0024234]
xref_analog: UniProt:P27091
relationship: sequence_of IMR:0003084 ! BMP-5 subfamily

[Term]
id: IMR:0003073
name: GDF-8
exact_synonym: "Growth/differentiation factor-8" []
exact_synonym: "myostatin" []
is_a: IMR:0000040 ! BMP family

[Term]
id: IMR:0003074
name: GDF8_HUMAN
exact_synonym: "GDF-8" [UniProt:O14793]
exact_synonym: "GDF8" [UniProt:O14793, EntrezGene:2660]
exact_synonym: "Growth/differentiation factor 8" [UniProt:O14793]
exact_synonym: "MSTN" [HGNC:4223, UniProt:O14793, EntrezGene:2660]
exact_synonym: "Myostatin" [UniProt:O14793]
exact_synonym: "myostatin" [HGNC:4223, EntrezGene:2660]
xref_analog: UniProt:O14793
relationship: sequence_of IMR:0003073 ! GDF-8

[Term]
id: IMR:0003075
name: GDF8_MOUSE
exact_synonym: "GDF-8" [UniProt:O08689]
exact_synonym: "Gdf8" [UniProt:O08689, MGI:95691]
exact_synonym: "Growth/differentiation factor 8" [UniProt:O08689]
exact_synonym: "Mstn" [UniProt:O08689, MGI:95691]
exact_synonym: "Myostatin" [UniProt:O08689]
exact_synonym: "myostatin" [MGI:95691]
xref_analog: UniProt:O08689
relationship: sequence_of IMR:0003073 ! GDF-8

[Term]
id: IMR:0003076
name: GDF8_RAT
exact_synonym: "GDF-8" [UniProt:O35312]
exact_synonym: "Gdf8" [UniProt:O35312]
exact_synonym: "Growth/differentiation factor 8" [UniProt:O35312]
exact_synonym: "Mstn" [RGD:3115, UniProt:O35312]
exact_synonym: "Myostatin" [UniProt:O35312]
exact_synonym: "myostatin" [RGD:3115]
xref_analog: UniProt:O35312
relationship: sequence_of IMR:0003073 ! GDF-8

[Term]
id: IMR:0003077
name: GDF-9
exact_synonym: "Growth/differentiation factor-9" []
is_a: IMR:0000040 ! BMP family

[Term]
id: IMR:0003078
name: GDF9_HUMAN
exact_synonym: "GDF-9" [UniProt:O60383]
exact_synonym: "GDF9" [MIM:601918, UniProt:O60383, EntrezGene:2661, HGNC:4224]
exact_synonym: "growth differentiation factor 9" [EntrezGene:2661, HGNC:4224]
exact_synonym: "Growth/differentiation factor 9" [MIM:601918, UniProt:O60383]
xref_analog: UniProt:O60383
relationship: sequence_of IMR:0003077 ! GDF-9

[Term]
id: IMR:0003079
name: GDF9_MOUSE
exact_synonym: "Gdf-9" [UniProt:Q07105, MGI:95692]
exact_synonym: "GDF-9" [UniProt:Q07105]
exact_synonym: "Gdf9" [UniProt:Q07105, MGI:95692]
exact_synonym: "growth differentiation factor 9" [MGI:95692]
exact_synonym: "Growth/differentiation factor 9" [UniProt:Q07105]
xref_analog: UniProt:Q07105
relationship: sequence_of IMR:0003077 ! GDF-9

[Term]
id: IMR:0003080
name: GDF-3
exact_synonym: "Growth/differentiation factor-3" []
exact_synonym: "Vgr-2" []
is_a: IMR:0000040 ! BMP family

[Term]
id: IMR:0003081
name: GDF3_HUMAN
exact_synonym: "GDF-3" [UniProt:Q9NR23]
exact_synonym: "GDF3" [HGNC:4218, UniProt:Q9NR23, MIM:606522, EntrezGene:9573]
exact_synonym: "growth differentiation factor 3" [HGNC:4218, EntrezGene:9573]
exact_synonym: "Growth/differentiation factor 3" [UniProt:Q9NR23, MIM:606522]
exact_synonym: "KFS3" [EntrezGene:9573]
exact_synonym: "MCOP7" [EntrezGene:9573]
exact_synonym: "MCOPCB6" [EntrezGene:9573]
xref_analog: UniProt:Q9NR23
relationship: sequence_of IMR:0003080 ! GDF-3

[Term]
id: IMR:0003082
name: GDF3_MOUSE
exact_synonym: "ecat9" [MGI:95686]
exact_synonym: "GDF-3" [UniProt:Q07104]
exact_synonym: "Gdf-3" [UniProt:Q07104, MGI:95686]
exact_synonym: "Gdf3" [UniProt:Q07104, MGI:95686]
exact_synonym: "growth differentiation factor 3" [MGI:95686]
exact_synonym: "Growth/differentiation factor 3" [UniProt:Q07104]
exact_synonym: "VG-1-related protein 2" [UniProt:Q07104]
exact_synonym: "Vgr-2" [UniProt:Q07104, MGI:95686]
exact_synonym: "Vgr2" [MGI:95686]
xref_analog: UniProt:Q07104
relationship: sequence_of IMR:0003080 ! GDF-3

[Term]
id: IMR:0003083
name: BMP-2 subfamily
def: "BMP-related proteins can be subdivided into several groups based on their structures and functions. BMP-2, BMP-4, and the Drosophila Dpp form one subgroup." [PubMed:15871923, PubMed:9720756, PubMed:9759503]
exact_synonym: "BMP-2/4 group" []
is_a: IMR:0000040 ! BMP family

[Term]
id: IMR:0003084
name: BMP-5 subfamily
def: "BMP-related proteins can be subdivided into several groups based on their structures and functions. BMP-5, BMP-6, BMP-7 (OP-1), BMP-8 (OP-2), and the Drosophila Gbb form one subgroup." [PubMed:15871923, PubMed:9720756, PubMed:9759503]
exact_synonym: "OP-1 group" []
is_a: IMR:0000040 ! BMP family

[Term]
id: IMR:0003085
name: GDF-5 subfamily
def: "BMP-related proteins can be subdivided into several groups based on their structures and functions. GDF-5 (CDMP- 1), GDF-6 (CDMP-2 or BMP-13), and GDF-7 (BMP-12) form one sugroup." [PubMed:15871923, PubMed:9720756, PubMed:9759503]
is_a: IMR:0000040 ! BMP family

[Term]
id: IMR:0010012
name: nucleoside diphosphate kinase
def: "Nucleoside diphoshate kinases (NDKs), an evolutionarily conserved family of proteins, synthesize nucleoside triphosphates from nucleoside diphosphates and ATP. To date, eight human NDK homologues have been identified." [PubMed:11768308, PubMed:16313181]
exact_synonym: "NDK" []
exact_synonym: "NDP kinase" []
exact_synonym: "Nm23" []
exact_synonym: "NME" []
xref_analog: EC:2.7.4.6
xref_analog: GO:0004550
is_a: IMR:0002599 ! nucleobase, nucleoside, nucleotide kinase

[Term]
id: IMR:0010013
name: NELF
exact_synonym: "negative elongation factor" []
is_a: IMR:0000917 ! pol II transcription elongation factor

[Term]
id: IMR:0010016
name: eIF
def: "Translation initiation in eukaryotes is an intricate process requiring at least 11 eukaryotic initiation factors (eIFs)." [PubMed:11426420, PubMed:12581660, PubMed:14635255]
exact_synonym: "eukaryotic initiation factor" []
is_a: IMR:0000901 ! translation initiation factor

[Term]
id: IMR:0010020
name: Elongin
exact_synonym: "SIII" []
is_a: IMR:0000917 ! pol II transcription elongation factor

[Term]
id: IMR:0010024
name: Heterogeneous nuclear ribonucleoprotein
is_a: IMR:0000925 ! splicing factor

[Term]
id: IMR:0010025
name: small nuclear ribonucleoprotein component
exact_synonym: "snRNP component" []
is_a: IMR:0000925 ! splicing factor

[Term]
id: IMR:0010026
name: Fructose-bisphosphate aldolase
is_a: IMR:0010054 ! lyase

[Term]
id: IMR:0010027
name: DNA polymerase
exact_synonym: "DNA nucleotidyltransferase (DNA-directed)" []
exact_synonym: "DNA-directed DNA polymerase" []
xref_analog: EC:2.7.7.7
xref_analog: GO:0003887
is_a: IMR:0000954 ! nucleotidyltransferase

[Term]
id: IMR:0010028
name: RNA polymerase
exact_synonym: "DNA-directed RNA polymerase" []
exact_synonym: "RNA nucleotidyltransferase (DNA-directed)" []
xref_analog: EC:2.7.7.6
xref_analog: GO:0003899
is_a: IMR:0000954 ! nucleotidyltransferase

[Term]
id: IMR:0010029
name: DNA primase
is_a: IMR:0000954 ! nucleotidyltransferase

[Term]
id: IMR:0010034
name: helicase
xref_analog: GO:0004386
is_a: IMR:0000207 ! enzyme

[Term]
id: IMR:0010038
name: nucleotidase
xref_analog: GO:0008252
is_a: IMR:0000517 ! phosphatase

[Term]
id: IMR:0010039
name: isomerase
xref_analog: EC:5.-.-.-
xref_analog: GO:0016853
is_a: IMR:0000207 ! enzyme

[Term]
id: IMR:0010040
name: Glutaminase
exact_synonym: "L-glutamine amidohydrolase" []
xref_analog: EC:3.5.1.2
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0010041
name: oxygenase
is_a: IMR:0000952 ! oxidoreductase

[Term]
id: IMR:0010043
name: decarboxylase
exact_synonym: "carboxy-lyase" []
xref_analog: EC:4.1.1.-
xref_analog: GO:0016831
is_a: IMR:0010054 ! lyase

[Term]
id: IMR:0010044
name: hydrolase
xref_analog: EC:3.-.-.-
xref_analog: GO:0016787
is_a: IMR:0000207 ! enzyme

[Term]
id: IMR:0010045
name: reductase
is_a: IMR:0000952 ! oxidoreductase

[Term]
id: IMR:0010046
name: carboxylase
xref_analog: EC:6.4.-.-
is_a: IMR:0010053 ! ligase

[Term]
id: IMR:0010047
name: dehydrogenase
is_a: IMR:0000952 ! oxidoreductase

[Term]
id: IMR:0010049
name: glycosylase
xref_analog: EC:3.2.-.-
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0010050
name: transferase
xref_analog: EC:2.-.-.-
is_a: IMR:0000207 ! enzyme

[Term]
id: IMR:0010051
name: enolase
exact_synonym: "2-phosphoglycerate dehydratase" []
exact_synonym: "Phosphopyruvate hydratase" []
xref_analog: EC:4.2.1.11
is_a: IMR:0010054 ! lyase

[Term]
id: IMR:0010052
name: peroxidase
xref_analog: EC:1.11.-.-
xref_analog: GO:0004601
is_a: IMR:0000952 ! oxidoreductase

[Term]
id: IMR:0010053
name: ligase
xref_analog: EC:6.-.-.-
xref_analog: GO:0016874
is_a: IMR:00002