format-version: 1.0
date: 03:10:2007 16:25
saved-by: yamamotosatoko
auto-generated-by: OBO-Edit 1.002
default-namespace: molecule_role
remark: version: 2.22
remark: cvs version: 1.7

[Term]
id: IMR:0000001
name: MoleculeRole

[Term]
id: IMR:0000002
name: ligand
def: "Binding to a specific receptor protein and activating intracellular signaling cascades that alter the behavior of the cell." [ISBN:0815340729]
xref_analog: GO:0005102
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000003
name: Wnt
xref_analog: GO:0005110
is_a: IMR:0000002 ! ligand

[Term]
id: IMR:0000004
name: hedgehog
exact_synonym: "Hh" []
xref_analog: GO:0005113
is_a: IMR:0000002 ! ligand

[Term]
id: IMR:0000005
name: Shh
exact_synonym: "HHG-1" []
exact_synonym: "Sonic hedgehog" []
is_a: IMR:0000004 ! hedgehog

[Term]
id: IMR:0000006
name: cytokine
xref_analog: GO:0005125
is_a: IMR:0000002 ! ligand

[Term]
id: IMR:0000007
name: Interleukin
exact_synonym: "IL" []
is_a: IMR:0000006 ! cytokine

[Term]
id: IMR:0000008
name: IL-2
exact_synonym: "Interleukin-2" []
exact_synonym: "TCGF" []
xref_analog: GO:0005134
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000009
name: IL-5
exact_synonym: "interleukin-5" []
xref_analog: GO:0005137
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000010
name: IL-6
exact_synonym: "interleukin-6" []
xref_analog: GO:0005138
is_a: IMR:0000007 ! Interleukin
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000011
name: IL-1
exact_synonym: "interleukin-1" []
xref_analog: GO:0005149
is_a: IMR:0000007 ! Interleukin
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000012
name: IL-3
exact_synonym: "interleukin-3" []
xref_analog: GO:0005135
is_a: IMR:0000007 ! Interleukin
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000013
name: IL-11
exact_synonym: "interleukin-11" []
xref_analog: GO:0005142
is_a: IMR:0000007 ! Interleukin
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000014
name: hematopoietic factor
is_a: IMR:0000006 ! cytokine

[Term]
id: IMR:0000015
name: TPO
exact_synonym: "thrombopoietin" []
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000016
name: EPO
exact_synonym: "erythropoietin" []
xref_analog: GO:0005128
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000017
name: G-CSF
exact_synonym: "granulocyte colony-stimulating factor" []
xref_analog: GO:0005130
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000018
name: GM-CSF
exact_synonym: "granulocyte-macrophage colony-stimulating factor" []
xref_analog: GO:0005129
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000019
name: LIF
exact_synonym: "leukemia inhibitory factor" []
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000020
name: SCF
exact_synonym: "stem cell factor" []
xref_analog: GO:0005173
is_a: IMR:0000014 ! hematopoietic factor

[Term]
id: IMR:0000021
name: TNF superfamily
xref_analog: GO:0005164
xref_analog: IPR:006052
is_a: IMR:0000006 ! cytokine

[Term]
id: IMR:0000022
name: FasL
exact_synonym: "CD178 antigen" []
exact_synonym: "CD95L" []
exact_synonym: "Fas ligand" []
exact_synonym: "FasL" []
exact_synonym: "Tumor necrosis factor ligand superfamily member 6" []
is_a: IMR:0000021 ! TNF superfamily

[Term]
id: IMR:0000023
name: CD40L
exact_synonym: "CD154" []
exact_synonym: "CD40 ligand" []
exact_synonym: "gp39" []
xref_analog: GO:0005174
is_a: IMR:0000021 ! TNF superfamily

[Term]
id: IMR:0000024
name: TNF family
comment: This term was made obsolete. To update annotations, consider the term 'IMR0000021:TNF superfamily'.
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0000025
name: TNF alpha
exact_synonym: "tumor necrosis factor alpha" []
is_a: IMR:0000021 ! TNF superfamily

[Term]
id: IMR:0000026
name: lymphotoxin alpha
exact_synonym: "LT alpha" []
exact_synonym: "lymphotoxin" []
exact_synonym: "TNF beta" []
is_a: IMR:0000021 ! TNF superfamily

[Term]
id: IMR:0000027
name: Interferon
exact_synonym: "IFN" []
is_a: IMR:0000006 ! cytokine

[Term]
id: IMR:0000028
name: IFN type I
exact_synonym: "type I Interferon" []
xref_analog: GO:0005132
is_a: IMR:0000027 ! Interferon

[Term]
id: IMR:0000029
name: IFN type II
exact_synonym: "type II Interferon" []
xref_analog: GO:0005133
is_a: IMR:0000027 ! Interferon

[Term]
id: IMR:0000030
name: growth factor
exact_synonym: "Growth Substance" []
xref_analog: GO:0008083
is_a: IMR:0000002 ! ligand

[Term]
id: IMR:0000031
name: VEGF
exact_synonym: "vascular endothelial growth factor" []
xref_analog: GO:0005172
is_a: IMR:0000030 ! growth factor

[Term]
id: IMR:0000032
name: PDGF
exact_synonym: "platelet derived growth factor" []
xref_analog: GO:0005161
is_a: IMR:0000030 ! growth factor

[Term]
id: IMR:0000033
name: HGF
exact_synonym: "hepatocyte growth factor" []
exact_synonym: "scatter factor" []
xref_analog: GO:0005171
is_a: IMR:0000030 ! growth factor

[Term]
id: IMR:0000034
name: NGF family
exact_synonym: "nerve growth factor family" []
exact_synonym: "neurotrophin" []
xref_analog: GO:0005165
is_a: IMR:0000030 ! growth factor

[Term]
id: IMR:0000035
name: type I cytokeratin
exact_synonym: "acidic cytokeratin" []
is_a: IMR:0000202 ! keratin

[Term]
id: IMR:0000036
name: TGF-beta superfamily
exact_synonym: "transforming growth factor beta superfamily" []
xref_analog: GO:0005160
is_a: IMR:0000030 ! growth factor

[Term]
id: IMR:0000037
name: inhibin
xref_analog: GO:0016916
is_a: IMR:0100496 ! TGF-beta like ligand

[Term]
id: IMR:0000038
name: dorsalin-1
is_a: IMR:0100500 ! BMP like ligand

[Term]
id: IMR:0000039
name: activin
xref_analog: GO:0016915
is_a: IMR:0100496 ! TGF-beta like ligand

[Term]
id: IMR:0000040
name: BMP family
exact_synonym: "Bone morphogenetic protein family" []
is_a: IMR:0100500 ! BMP like ligand

[Term]
id: IMR:0000041
name: TGF-beta family
xref_analog: GO:0005160
is_a: IMR:0100496 ! TGF-beta like ligand

[Term]
id: IMR:0000042
name: TGF-beta1
exact_synonym: "transforming growth factor-beta 1" []
xref_analog: GO:0005160
is_a: IMR:0000041 ! TGF-beta family

[Term]
id: IMR:0000043
name: TGF-beta2
exact_synonym: "transforming growth factor-beta 2" []
xref_analog: GO:0005160
is_a: IMR:0000041 ! TGF-beta family

[Term]
id: IMR:0000044
name: TGF-beta3
exact_synonym: "transforming growth factor-beta 3" []
xref_analog: GO:0005160
is_a: IMR:0000041 ! TGF-beta family

[Term]
id: IMR:0000045
name: GDNF
exact_synonym: "Glial cell line-derived neurotrophic factor" []
xref_analog: GO:0005160
is_a: IMR:0000030 ! growth factor

[Term]
id: IMR:0000046
name: Nodal family
is_a: IMR:0000030 ! growth factor

[Term]
id: IMR:0000047
name: EGF family
exact_synonym: "epidermal growth factor family" []
is_a: IMR:0000030 ! growth factor

[Term]
id: IMR:0000048
name: neuregulin
exact_synonym: "NRG" []
is_a: IMR:0000047 ! EGF family

[Term]
id: IMR:0000049
name: FGF
exact_synonym: "Fibroblast growth factor" []
exact_synonym: "HBGF" []
exact_synonym: "Heparin-binding growth factor" []
xref_analog: GO:0005104
is_a: IMR:0000030 ! growth factor

[Term]
id: IMR:0000050
name: type II cytokeratin
exact_synonym: "neutral to basic cytokeratin" []
is_a: IMR:0000202 ! keratin

[Term]
id: IMR:0000051
name: leptin
is_a: IMR:0100046 ! peptide hormone

[Term]
id: IMR:0000052
name: insulin
alt_id: IMR:0010309
alt_id: IMR:0011543
alt_id: IMR:0011922
def: "A protein hormone secreted by beta cells of the pancreas. Insulin plays a major role in the regulation of glucose metabolism, generally promoting the cellular utilization of glucose. It is also an important regulator of protein and lipid metabolism. Insulin is used as a drug to control insulin-dependent diabetes mellitus." [MeSH:D007328]
exact_synonym: "Humulin" []
exact_synonym: "insulin A chain" []
exact_synonym: "insulin B chain" []
exact_synonym: "insulin fragments" []
exact_synonym: "Insulin precursor" []
xref_analog: ENSEMBL:ENSDARP00000025209
xref_analog: ENSEMBL:SINFRUP00000131008
xref_analog: GO:0016088
xref_analog: KEGG:C00723
xref_analog: MeSH:D007328
is_a: IMR:0100076 ! pancreatic hormone

[Term]
id: IMR:0000053
name: cytokeratin 1
is_a: IMR:0000050 ! type II cytokeratin

[Term]
id: IMR:0000054
name: receptor
def: "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GO:0004872]
xref_analog: GO:0004872
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000055
name: Frizzled
exact_synonym: "Fz" []
xref_analog: GO:0042813
is_a: IMR:0100801 ! FZ/SMO family

[Term]
id: IMR:0000056
name: TNFR family
exact_synonym: "tumor necrosis factor receptor family" []
xref_analog: GO:0005027
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000057
name: CD40
xref_analog: GO:0005028
is_a: IMR:0000056 ! TNFR family

[Term]
id: IMR:0000058
name: FasR
exact_synonym: "Apo-1" []
exact_synonym: "CD95" []
exact_synonym: "Fas receptor" []
is_a: IMR:0000056 ! TNFR family

[Term]
id: IMR:0000059
name: p75NTR
exact_synonym: "neurotrophin receptor" []
xref_analog: GO:0005030
is_a: IMR:0000056 ! TNFR family
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000060
name: TNFR1
exact_synonym: "tumor necrosis factor receptor, type I" []
xref_analog: GO:0005032
is_a: IMR:0100674 ! TNF alpha receptor

[Term]
id: IMR:0000061
name: TNFR2
exact_synonym: "tumor necrosis factor receptor, type II" []
xref_analog: GO:0005033
is_a: IMR:0100674 ! TNF alpha receptor

[Term]
id: IMR:0000062
name: receptor protein-tyrosine phosphatase
exact_synonym: "receptor-like protein tyrosine phosphatase" []
exact_synonym: "RPTP" []
xref_analog: GO:0005001
is_a: IMR:0000273 ! protein tyrosine phosphatase
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000063
name: receptor tyrosine kinase
exact_synonym: "transmembrane receptor tyrosine kinase" []
xref_analog: GO:0004714
is_a: IMR:0000210 ! protein tyrosine kinase
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000064
name: Flt
exact_synonym: "fms-like tyrosine kinase" []
exact_synonym: "vascular endothelial growth factor receptor" []
exact_synonym: "VEGF receptor" []
xref_analog: GO:0005021
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000065
name: Flt-1
exact_synonym: "Fms-like tyrosine kinase 1" []
exact_synonym: "Vascular endothelial growth factor receptor 1" []
exact_synonym: "VEGFR-1" []
is_a: IMR:0000064 ! Flt

[Term]
id: IMR:0000066
name: KDR
exact_synonym: "Flk-1" []
exact_synonym: "Kinase insert domain receptor" []
exact_synonym: "Vascular endothelial growth factor receptor 2" []
exact_synonym: "VEGFR-2" []
is_a: IMR:0000064 ! Flt

[Term]
id: IMR:0000067
name: Flt-4
exact_synonym: "Vascular endothelial growth factor receptor 3" []
exact_synonym: "VEGFR-3" []
is_a: IMR:0000064 ! Flt

[Term]
id: IMR:0000068
name: PDGF receptor
exact_synonym: "platelet derived growth factor receptor" []
xref_analog: GO:0005017
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000069
name: alpha PDGF receptor
exact_synonym: "alpha platelet derived growth factor receptor" []
xref_analog: GO:0005018
is_a: IMR:0000068 ! PDGF receptor

[Term]
id: IMR:0000070
name: beta PDGF receptor
exact_synonym: "beta platelet derived growth factor receptor" []
xref_analog: GO:0005019
is_a: IMR:0000068 ! PDGF receptor

[Term]
id: IMR:0000071
name: Met
exact_synonym: "hepatocyte growth factor receptor" []
exact_synonym: "HGF receptor" []
xref_analog: GO:0005008
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000072
name: TRK
exact_synonym: "nerve growth factor receptor" []
exact_synonym: "NGF receptor" []
exact_synonym: "tropomyosin-receptor-kinase" []
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000073
name: 7LESS_DROME
exact_synonym: "7LES" [FlyBase:FBgn0003366]
exact_synonym: "7less" [FlyBase:FBgn0003366]
exact_synonym: "CG18085" [FlyBase:FBgn0003366]
exact_synonym: "CT3980" [FlyBase:FBgn0003366]
exact_synonym: "DmHD-265" [FlyBase:FBgn0003366]
exact_synonym: "DROSEV" [FlyBase:FBgn0003366]
exact_synonym: "DROSEV1" [FlyBase:FBgn0003366]
exact_synonym: "EC 2.7.10.1" [UniProt:P13368]
exact_synonym: "HD-265" [UniProt:P13368, FlyBase:FBgn0003366]
exact_synonym: "Protein sevenless" [UniProt:P13368]
exact_synonym: "sev" [UniProt:P13368, FlyBase:FBgn0003366]
exact_synonym: "Sev" [FlyBase:FBgn0003366]
exact_synonym: "sev(AC)[[14]]" [FlyBase:FBgn0003366]
exact_synonym: "sevenless" [FlyBase:FBgn0003366]
xref_analog: UniProt:P13368
relationship: sequence_of IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000074
name: Kit
exact_synonym: "c-Kit" []
exact_synonym: "mast/stem cell growth factor receptor" []
xref_analog: GO:0005020
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000075
name: insulin receptor family
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000076
name: ALK
exact_synonym: "anaplastic lymphoma kinase" []
is_a: IMR:0000075 ! insulin receptor family

[Term]
id: IMR:0000077
name: LTK
exact_synonym: "leukocyte tyrosine kinase" []
is_a: IMR:0000075 ! insulin receptor family

[Term]
id: IMR:0000078
name: insulin receptor
alt_id: IMR:0010308
alt_id: IMR:0011304
alt_id: IMR:0011542
exact_synonym: "CD220 antigen" []
exact_synonym: "insulin receptor alpha subunit" []
exact_synonym: "insulin receptor beta subunit" []
exact_synonym: "insulin receptor precursor" []
exact_synonym: "IR" []
xref_analog: ENSEMBL:ENSMUSP00000049986
xref_analog: ENSEMBL:SINFRUP00000144373
xref_analog: GO:0005009
is_a: IMR:0000075 ! insulin receptor family

[Term]
id: IMR:0000079
name: RET
exact_synonym: "glial cell line-derived neurotrophic factor receptor" []
xref_analog: GO:0016167
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000080
name: FGFR
def: "The vertebrate Fgfr gene family consists of four highly related genes, Fgfr1-4." [PubMed:15689573]
exact_synonym: "fibroblast growth factor receptor" []
xref_analog: GO:0005007
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000081
name: EGFR
exact_synonym: "epidermal growth factor receptor" []
xref_analog: GO:0005006
is_a: IMR:0000063 ! receptor tyrosine kinase

[Term]
id: IMR:0000082
name: ligand-gated ion channel
exact_synonym: "receptor-channel" []
xref_analog: GO:0015276
is_a: IMR:0000481 ! ion channel

[Term]
id: IMR:0000083
name: NMDAR
exact_synonym: "N-methyl-D-aspartate receptor" []
xref_analog: GO:0004972
is_a: IMR:0000498 ! cation channel
is_a: IMR:0000747 ! extracellular ligand-gated ion channel

[Term]
id: IMR:0000084
name: IP3 receptor
exact_synonym: "inositol-1,4,5-triphosphate receptor" []
exact_synonym: "IP3R" []
xref_analog: GO:0008095
is_a: IMR:0000499 ! calcium channel
is_a: IMR:0000746 ! intracellular ligand-gated ion channel

[Term]
id: IMR:0000085
name: nuclear receptor
xref_analog: GO:0004879
is_a: IMR:0000369 ! transcriptional regulator
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000086
name: TR
exact_synonym: "c-erbA" []
exact_synonym: "thyroid hormone receptor" []
xref_analog: GO:0004887
is_a: IMR:0000085 ! nuclear receptor

[Term]
id: IMR:0000087
name: cytokeratin 3
is_a: IMR:0000050 ! type II cytokeratin

[Term]
id: IMR:0000088
name: Estrogen receptor
is_a: IMR:0000085 ! nuclear receptor

[Term]
id: IMR:0000089
name: PPAR
exact_synonym: "Peroxisome proliferator activated receptor" []
is_a: IMR:0000085 ! nuclear receptor

[Term]
id: IMR:0000090
name: RAR
exact_synonym: "Retinoic acid receptor" []
is_a: IMR:0000085 ! nuclear receptor

[Term]
id: IMR:0000091
name: receptor serine/threonine kinase
xref_analog: GO:0004675
is_a: IMR:0000223 ! protein serine/threonine kinase
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000092
name: TGF-beta receptor
exact_synonym: "Transforming growth factor-beta receptor" []
xref_analog: GO:0005024
is_a: IMR:0000091 ! receptor serine/threonine kinase

[Term]
id: IMR:0000093
name: TGF-beta receptor type I
exact_synonym: "Transforming growth factor-beta receptor type I" []
xref_analog: GO:0005025
is_a: IMR:0000092 ! TGF-beta receptor

[Term]
id: IMR:0000094
name: TGF-beta receptor type II
exact_synonym: "Transforming growth factor-beta receptor type II" []
xref_analog: GO:0005026
is_a: IMR:0000092 ! TGF-beta receptor

[Term]
id: IMR:0000095
name: cytokine receptor
xref_analog: GO:0004896
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000096
name: interleukin receptor
xref_analog: GO:0004907
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000097
name: IL-2R
exact_synonym: "interleukin-2 receptor" []
xref_analog: GO:0004911
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000098
name: IL-2R alpha chain
exact_synonym: "CD25" []
exact_synonym: "Interleukin-2 receptor alpha chain" []
relationship: part_of IMR:0000097 ! IL-2R

[Term]
id: IMR:0000099
name: IL-2R beta chain
exact_synonym: "CD122" []
exact_synonym: "Interleukin-2 receptor beta chain" []
relationship: part_of IMR:0000097 ! IL-2R
relationship: part_of IMR:0000117 ! IL-15R

[Term]
id: IMR:0000100
name: common gamma chain
exact_synonym: "gamma c" []
exact_synonym: "p64" []
is_a: IMR:0100641 ! IL-13R subunit
is_a: IMR:0100643 ! IL-4R subunit
relationship: part_of IMR:0000097 ! IL-2R
relationship: part_of IMR:0000111 ! IL-7R
relationship: part_of IMR:0000113 ! IL-9R
relationship: part_of IMR:0000117 ! IL-15R

[Term]
id: IMR:0000101
name: IL-5R
exact_synonym: "interleukin-5 receptor" []
xref_analog: GO:0004914
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000102
name: IL-5R alpha
exact_synonym: "interleukin-5 receptor alpha chain" []
relationship: part_of IMR:0000101 ! IL-5R

[Term]
id: IMR:0000103
name: common beta chain
exact_synonym: "beta c" []
relationship: part_of IMR:0000101 ! IL-5R
relationship: part_of IMR:0000109 ! IL-3R
relationship: part_of IMR:0000131 ! GM-CSFR

[Term]
id: IMR:0000104
name: IL-6R
exact_synonym: "interleukin-6 receptor" []
xref_analog: GO:0004915
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000105
name: gp130
exact_synonym: "Interleukin-6 receptor beta chain" []
xref_analog: GO:0004898
is_a: IMR:0000130 ! LIFR
relationship: part_of IMR:0000104 ! IL-6R
relationship: part_of IMR:0000129 ! OSMR

[Term]
id: IMR:0000106
name: IL-6R alpha
exact_synonym: "interleukin-6 receptor alpha chain" []
relationship: part_of IMR:0000104 ! IL-6R

[Term]
id: IMR:0000107
name: IL-4R
exact_synonym: "interleukin-4 receptor" []
xref_analog: GO:0004913
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000108
name: IL-4R alpha
exact_synonym: "interleukin-4 receptor alpha chain" []
is_a: IMR:0100641 ! IL-13R subunit
is_a: IMR:0100643 ! IL-4R subunit

[Term]
id: IMR:0000109
name: IL-3R
exact_synonym: "interleukin-3 receptor" []
xref_analog: GO:0004912
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000110
name: IL-3R alpha
exact_synonym: "interleukin-3 receptor alpha chain" []
relationship: part_of IMR:0000109 ! IL-3R

[Term]
id: IMR:0000111
name: IL-7R
exact_synonym: "interleukin-7 receptor" []
xref_analog: GO:0004917
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000112
name: IL-7R alpha
exact_synonym: "interleukin-7 receptor alpha chain" []
relationship: part_of IMR:0000111 ! IL-7R

[Term]
id: IMR:0000113
name: IL-9R
exact_synonym: "interleukin-9 receptor" []
xref_analog: GO:0004919
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000114
name: IL-9R alpha
exact_synonym: "interleukin-9 receptor alpha chain" []
relationship: part_of IMR:0000113 ! IL-9R

[Term]
id: IMR:0000115
name: IL-13R
exact_synonym: "interleukin-13 receptor" []
xref_analog: GO:0016515
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000116
name: IL-13R alpha-2
exact_synonym: "interleukin-13 receptor alpha-2 chain" []
is_a: IMR:0100641 ! IL-13R subunit

[Term]
id: IMR:0000117
name: IL-15R
exact_synonym: "interleukin-15 receptor" []
xref_analog: GO:0042010
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000118
name: IL-15R alpha
exact_synonym: "interleukin-15 receptor alpha chain" []
relationship: part_of IMR:0000117 ! IL-15R

[Term]
id: IMR:0000120
name: IL-1R
exact_synonym: "interleukin-1 receptor" []
xref_analog: GO:0004908
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000121
name: IL-1RI
exact_synonym: "IL-1R-alpha" []
exact_synonym: "interleukin-1 receptor type I" []
relationship: part_of IMR:0000593 ! IL-1RI : IL-1R AcP

[Term]
id: IMR:0000122
name: IL-1RII
exact_synonym: "IL-1R-beta" []
exact_synonym: "interleukin-1 receptor type II" []
relationship: part_of IMR:0000594 ! IL-1RII : IL-1R AcP

[Term]
id: IMR:0000123
name: IL-18R
exact_synonym: "IL-1Rrp" []
exact_synonym: "IL1 receptor-related protein" []
exact_synonym: "Interleukin-18 receptor" []
xref_analog: GO:0042008
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000124
name: TLR
exact_synonym: "Toll-like receptor" []
is_a: IMR:0001791 ! pattern recognition receptor

[Term]
id: IMR:0000125
name: leptin receptor
exact_synonym: "OB-R" []
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000126
name: c-mpl
exact_synonym: "thrombopoietin receptor" []
exact_synonym: "TPOR" []
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000127
name: EPOR
exact_synonym: "erythropoietin receptor" []
xref_analog: GO:0004900
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000128
name: G-CSFR
exact_synonym: "granulocyte colony-stimulating factor receptor" []
xref_analog: GO:0004902
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000129
name: OSMR
exact_synonym: "oncostatin-M receptor" []
xref_analog: GO:0004924
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000130
name: LIFR
exact_synonym: "leukemia inhibitory factor receptor" []
xref_analog: GO:0004899
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000131
name: GM-CSFR
exact_synonym: "granulocyte-macrophage colony-stimulating factor receptor" []
xref_analog: GO:0004901
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000132
name: GM-CSFR alpha
exact_synonym: "granulocyte-macrophage colony-stimulating factor receptor alpha chain" []
relationship: part_of IMR:0000131 ! GM-CSFR

[Term]
id: IMR:0000133
name: CNTFR
exact_synonym: "ciliary neurotrophic factor receptor" []
xref_analog: GO:0004897
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000134
name: IFNR
exact_synonym: "interferon receptor" []
xref_analog: GO:0004904
is_a: IMR:0000095 ! cytokine receptor

[Term]
id: IMR:0000135
name: IFNR type I
exact_synonym: "IFNAR" []
exact_synonym: "Interferon alpha/beta receptor" []
xref_analog: GO:0004905
is_a: IMR:0000134 ! IFNR

[Term]
id: IMR:0000136
name: IFNR type II
exact_synonym: "IFNGR" []
exact_synonym: "Interferon-gamma receptor" []
xref_analog: GO:0004906
is_a: IMR:0000134 ! IFNR

[Term]
id: IMR:0000137
name: G-Protein Coupled Receptor
exact_synonym: "GPCR" []
xref_analog: GO:0004930
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000138
name: Rhodopsin-like GPCR(typeA)
xref_analog: GO:0001584
is_a: IMR:0000137 ! G-Protein Coupled Receptor

[Term]
id: IMR:0000139
name: secretin like receptors(type B)
xref_analog: GO:0001633
is_a: IMR:0000137 ! G-Protein Coupled Receptor

[Term]
id: IMR:0000140
name: metabotropic glutamate/pheromone receptors(type C)
xref_analog: GO:0008067
is_a: IMR:0000137 ! G-Protein Coupled Receptor

[Term]
id: IMR:0000141
name: patched
xref_analog: GO:0008158
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000142
name: MHC
exact_synonym: "major histocompatibility complex" []
xref_analog: GO:0042611
is_a: IMR:0000950 ! cellular structure protein

[Term]
id: IMR:0000143
name: MHC class I molecule
def: "MHC class Ia (classical) molecules, termed human leukocyte antigen (HLA)-A, HLA-B and HLA-C in humans and H2-K, H2-D and H2-L in mice, are highly polymorphic glycoproteins composed of a single membrane-spanning alpha chain paired with the soluble protein beta2 microglobulin." [ISBN:0815340729, PubMed:10607669, PubMed:16860610]
exact_synonym: "classical MHC class I molecule" []
exact_synonym: "major histocompatibility complex class I molecule" []
exact_synonym: "MHC class Ia molecule" []
xref_analog: GO:0042612
is_a: IMR:0000142 ! MHC

[Term]
id: IMR:0000144
name: MHC class II molecule
def: "MHC class II molecules are composed of membrane-spanning alpha and beta chains." [ISBN:0815340729, PubMed:10607669]
exact_synonym: "classical MHC class II molecule" []
exact_synonym: "major histocompatibility complex class II molecule" []
xref_analog: GO:0042613
is_a: IMR:0000142 ! MHC

[Term]
id: IMR:0000145
name: CD4/CD8
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000146
name: cytokeratin 4
is_a: IMR:0000050 ! type II cytokeratin

[Term]
id: IMR:0000147
name: CD3
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000148
name: CD3 gamma-epsilon dimer
relationship: part_of IMR:0002408 ! alpha beta TCR-CD3 complex
relationship: part_of IMR:0002409 ! gamma delta TCR-CD3 complex

[Term]
id: IMR:0000149
name: CD3 delta-epsilon dimer
relationship: part_of IMR:0002408 ! alpha beta TCR-CD3 complex

[Term]
id: IMR:0000150
name: CD3 zeta-zeta dimer
relationship: part_of IMR:0002408 ! alpha beta TCR-CD3 complex
relationship: part_of IMR:0002409 ! gamma delta TCR-CD3 complex

[Term]
id: IMR:0000151
name: TCR family
exact_synonym: "T-cell receptor" []
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000152
name: scavenger receptor family
xref_analog: GO:0005044
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000153
name: BCR
exact_synonym: "B cell receptor" []
exact_synonym: "B cell receptor complex" []
exact_synonym: "B-cell antigen receptor" []
exact_synonym: "BCR complex" []
xref_analog: GO:0019815
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000154
name: lgM
exact_synonym: "immunoglobulin M" []
is_a: IMR:0002090 ! immunoglobulin
relationship: part_of IMR:0000153 ! BCR

[Term]
id: IMR:0000155
name: Ig alpha:beta
relationship: part_of IMR:0000153 ! BCR
relationship: part_of IMR:0002097 ! pre-BCR

[Term]
id: IMR:0000156
name: FcR
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000157
name: FcepsilonRI
is_a: IMR:0000156 ! FcR

[Term]
id: IMR:0000158
name: FcgammaRI
exact_synonym: "High affinity immunoglobulin gamma Fc receptor I" []
is_a: IMR:0000156 ! FcR

[Term]
id: IMR:0000159
name: FcgammaRIII
exact_synonym: "Low affinity immunoglobulin gamma FC region receptor III" []
is_a: IMR:0000156 ! FcR

[Term]
id: IMR:0000160
name: FcgammaRII
exact_synonym: "Low affinity immunoglobulin gamma Fc region receptor II" []
is_a: IMR:0000156 ! FcR

[Term]
id: IMR:0000161
name: receptor guanylate cyclase
xref_analog: GO:0008075
is_a: IMR:0000314 ! guanylate cyclase
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000162
name: cytokeratin 5
is_a: IMR:0000050 ! type II cytokeratin

[Term]
id: IMR:0000163
name: cytokeratin 7
is_a: IMR:0000050 ! type II cytokeratin

[Term]
id: IMR:0000164
name: cytokeratin 8
is_a: IMR:0000050 ! type II cytokeratin

[Term]
id: IMR:0000165
name: cytokeratin 6A
is_a: IMR:0000469 ! cytokeratin 6

[Term]
id: IMR:0000166
name: adhesion molecule
is_a: IMR:0000950 ! cellular structure protein

[Term]
id: IMR:0000167
name: cadherin
is_a: IMR:0000166 ! adhesion molecule

[Term]
id: IMR:0000168
name: E-cadherin
exact_synonym: "Arc-1" []
exact_synonym: "cadherin-1" []
exact_synonym: "cell-CAM120/80" []
exact_synonym: "Epithelial-cadherin" []
exact_synonym: "L-CAM" []
exact_synonym: "Uvomorulin" []
is_a: IMR:0000167 ! cadherin

[Term]
id: IMR:0000169
name: N-cadherin
exact_synonym: "A-CAM" []
exact_synonym: "cadherin-2" []
exact_synonym: "Neural-cadherin" []
is_a: IMR:0000167 ! cadherin

[Term]
id: IMR:0000170
name: R-cadherin
exact_synonym: "cadherin-4" []
exact_synonym: "Retinal-cadherin" []
is_a: IMR:0000167 ! cadherin

[Term]
id: IMR:0000171
name: VE-cadherin
exact_synonym: "cadherin-5" []
exact_synonym: "Vascular endothelial-cadherin" []
is_a: IMR:0000167 ! cadherin

[Term]
id: IMR:0000172
name: integrin
def: "Integrins comprise a large family of cell surface receptors that are found in many animal species, ranging from sponge to mammals. They are composed of two subunits, alpha and beta, and each alpha beta combination has its own binding specificity and signaling properties." [PubMed:10446041]
is_a: IMR:0000166 ! adhesion molecule
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000173
name: Integrin alpha
is_a: IMR:0000172 ! integrin

[Term]
id: IMR:0000174
name: Integrin beta
is_a: IMR:0000172 ! integrin

[Term]
id: IMR:0000176
name: alpha-catenin
is_a: IMR:0000166 ! adhesion molecule

[Term]
id: IMR:0000177
name: beta-catenin
comment: named 'beta-catenin family' formerly.
is_a: IMR:0000166 ! adhesion molecule
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000178
name: ICAM
exact_synonym: "intercellular adhesion molecule" []
is_a: IMR:0000166 ! adhesion molecule

[Term]
id: IMR:0000180
name: N-CAM
exact_synonym: "neuronal cell adhesion molecule" []
is_a: IMR:0000166 ! adhesion molecule

[Term]
id: IMR:0000182
name: selectin
is_a: IMR:0000166 ! adhesion molecule

[Term]
id: IMR:0000183
name: nectin
is_a: IMR:0000166 ! adhesion molecule

[Term]
id: IMR:0000184
name: ponsin
is_a: IMR:0000166 ! adhesion molecule

[Term]
id: IMR:0000185
name: cytoskeletal protein
xref_analog: GO:0005200
xref_analog: GO:0005856
is_a: IMR:0000950 ! cellular structure protein

[Term]
id: IMR:0000186
name: ERM family
exact_synonym: "ezrin/radixin/moesin family" []
is_a: IMR:0000185 ! cytoskeletal protein

[Term]
id: IMR:0000187
name: paxillin
is_a: IMR:0000188 ! microfilament cytoskeletal protein
is_a: IMR:0000333 ! adaptor/docking/scaffold/anchoring protein

[Term]
id: IMR:0000188
name: microfilament cytoskeletal protein
exact_synonym: "actin filament cytoskeletal protein" []
xref_analog: GO:0015629
is_a: IMR:0000185 ! cytoskeletal protein

[Term]
id: IMR:0000189
name: alpha-actinin
is_a: IMR:0000477 ! actin cross linking protein

[Term]
id: IMR:0000190
name: actin
is_a: IMR:0000494 ! microfilament protein

[Term]
id: IMR:0000191
name: myosin
is_a: IMR:0000188 ! microfilament cytoskeletal protein
is_a: IMR:0000518 ! motor protein

[Term]
id: IMR:0000192
name: tropomyosin
is_a: IMR:0000188 ! microfilament cytoskeletal protein

[Term]
id: IMR:0000193
name: troponin
is_a: IMR:0000188 ! microfilament cytoskeletal protein

[Term]
id: IMR:0000194
name: profilin
is_a: IMR:0000188 ! microfilament cytoskeletal protein

[Term]
id: IMR:0000195
name: spectrin
is_a: IMR:0000188 ! microfilament cytoskeletal protein

[Term]
id: IMR:0000196
name: microtubule cytoskeletal protein
xref_analog: GO:0015630
is_a: IMR:0000185 ! cytoskeletal protein

[Term]
id: IMR:0000197
name: tubulin
is_a: IMR:0000495 ! microtubule protein

[Term]
id: IMR:0000199
name: kinesin
is_a: IMR:0100192 ! kinesin superfamily

[Term]
id: IMR:0000200
name: dynein
is_a: IMR:0000196 ! microtubule cytoskeletal protein
is_a: IMR:0000518 ! motor protein

[Term]
id: IMR:0000201
name: intermediate filament cytoskeletal protein
xref_analog: GO:0045111
is_a: IMR:0000185 ! cytoskeletal protein

[Term]
id: IMR:0000202
name: keratin
exact_synonym: "cytokeratin" []
is_a: IMR:0000496 ! intermediate filament protein

[Term]
id: IMR:0000203
name: neurofilament protein
xref_analog: GO:0005883
is_a: IMR:0000496 ! intermediate filament protein

[Term]
id: IMR:0000204
name: dystrophin
is_a: IMR:0000185 ! cytoskeletal protein

[Term]
id: IMR:0000205
name: APC
exact_synonym: "Adenomatous Polyposis Coli Protein" []
is_a: IMR:0000185 ! cytoskeletal protein
is_a: IMR:0001160 ! negative regulator of Wnt signaling pathway

[Term]
id: IMR:0000206
name: ankyrin
is_a: IMR:0000185 ! cytoskeletal protein

[Term]
id: IMR:0000207
name: enzyme
xref_analog: GO:0003824
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000208
name: cytokeratin 6B
alt_id: IMR:0000302
exact_synonym: "cytokeratin 6F" []
is_a: IMR:0000469 ! cytokeratin 6

[Term]
id: IMR:0000209
name: protein kinase
xref_analog: GO:0004672
is_a: IMR:0000512 ! kinase

[Term]
id: IMR:0000210
name: protein tyrosine kinase
exact_synonym: "PTK" []
xref_analog: GO:0004713
is_a: IMR:0000209 ! protein kinase

[Term]
id: IMR:0000211
name: Src family
is_a: IMR:0000682 ! non-receptor tyrosine kinase

[Term]
id: IMR:0000212
name: Csk
exact_synonym: "C-terminal Src kinase" []
is_a: IMR:0000682 ! non-receptor tyrosine kinase

[Term]
id: IMR:0000213
name: JAK
exact_synonym: "Janus kinase" []
xref_analog: GO:0004718
is_a: IMR:0000682 ! non-receptor tyrosine kinase

[Term]
id: IMR:0000214
name: BTK/Tec
is_a: IMR:0000682 ! non-receptor tyrosine kinase

[Term]
id: IMR:0000215
name: BTK
exact_synonym: "Atk" []
exact_synonym: "Bpk" []
exact_synonym: "Bruton's tyrosine kinase" []
exact_synonym: "Emb" []
is_a: IMR:0000214 ! BTK/Tec

[Term]
id: IMR:0000216
name: Tec
exact_synonym: "Tec protein tyrosine kinase" []
is_a: IMR:0000214 ! BTK/Tec

[Term]
id: IMR:0000217
name: Fak/Pyk2
is_a: IMR:0000682 ! non-receptor tyrosine kinase

[Term]
id: IMR:0000218
name: Fak
exact_synonym: "Focal adhesion kinase" []
xref_analog: GO:0004717
is_a: IMR:0000217 ! Fak/Pyk2

[Term]
id: IMR:0000219
name: Pyk2
exact_synonym: "CADTK" []
exact_synonym: "Cak beta" []
exact_synonym: "calcium-dependent tyrosine kinase" []
exact_synonym: "cell adhesion kinase beta" []
exact_synonym: "prolin-rich tyrosine kinase 2" []
exact_synonym: "RAFTK" []
exact_synonym: "related adhesion focal tyrosine kinase" []
is_a: IMR:0000217 ! Fak/Pyk2

[Term]
id: IMR:0000220
name: ZAP-70/Syk
is_a: IMR:0000682 ! non-receptor tyrosine kinase

[Term]
id: IMR:0000221
name: ZAP-70
is_a: IMR:0000220 ! ZAP-70/Syk

[Term]
id: IMR:0000222
name: Syk
exact_synonym: "Spleen tyrosine kinase" []
is_a: IMR:0000220 ! ZAP-70/Syk

[Term]
id: IMR:0000223
name: protein serine/threonine kinase
xref_analog: GO:0004674
is_a: IMR:0000209 ! protein kinase

[Term]
id: IMR:0000224
name: MAPK
def: "Mammals express at least four distinctly regulated groups of MAPKs, ERK-1/2, JNK/SAPK, p38 and ERK5. MAPKs are activated by dual phosphorylation on both tyrosine and threonine residues of a conserved TXY motif." [PubMed:11242034, PubMed:9922370]
exact_synonym: "MAP kinase" []
exact_synonym: "mitogen-activated protein kinase" []
xref_analog: GO:0004707
xref_analog: IPR:003527
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000225
name: JNK/SAPK
exact_synonym: "c-jun N-terminal kinase" []
exact_synonym: "stress-activated protein kinase" []
xref_analog: GO:0016909
xref_analog: IPR:008351
is_a: IMR:0000224 ! MAPK

[Term]
id: IMR:0000226
name: p38
xref_analog: IPR:008352
is_a: IMR:0000224 ! MAPK

[Term]
id: IMR:0000227
name: ERK1/2
def: "ERKs are the archetypal MAPKs. ERK1 and ERK2, proteins of 43 and 41kDa respectively, are ~85% identical. Activated by the phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence." [PubMed:10487205]
exact_synonym: "ERK" []
exact_synonym: "Extracellular signal-regulated kinase" []
exact_synonym: "MAPK/ERK" []
exact_synonym: "p42/p44 MAP kinase" []
exact_synonym: "p42/p44 MAPK" []
xref_analog: IPR:008349
is_a: IMR:0000224 ! MAPK

[Term]
id: IMR:0000229
name: MAPKKK
exact_synonym: "MAP kinase kinase kinase" []
exact_synonym: "MAPKK kinase" []
exact_synonym: "MKKK" []
xref_analog: GO:0004709
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000230
name: mos
exact_synonym: "c-mos" []
is_a: IMR:0000229 ! MAPKKK

[Term]
id: IMR:0000231
name: Raf
is_a: IMR:0000229 ! MAPKKK

[Term]
id: IMR:0000232
name: TAK1
exact_synonym: "MOM-4" []
exact_synonym: "TGF-bata activated kinase 1" []
is_a: IMR:0000229 ! MAPKKK

[Term]
id: IMR:0000233
name: Tpl2
exact_synonym: "cancer Osaka thyroid oncogene" []
exact_synonym: "Cot" []
exact_synonym: "Est" []
exact_synonym: "Tumor progression locus 2" []
is_a: IMR:0000229 ! MAPKKK

[Term]
id: IMR:0000234
name: MEKK
exact_synonym: "MAPK/ERK kinase kinase" []
xref_analog: GO:0004710
is_a: IMR:0000229 ! MAPKKK

[Term]
id: IMR:0000238
name: PAK
is_a: IMR:0000229 ! MAPKKK
is_a: IMR:0000252 ! Ste20 homolog family

[Term]
id: IMR:0000239
name: MLK family
is_a: IMR:0000229 ! MAPKKK

[Term]
id: IMR:0000242
name: NIK
exact_synonym: "NF-kappa B-inducing kinase" []
xref_analog: GO:0004704
is_a: IMR:0000229 ! MAPKKK

[Term]
id: IMR:0000243
name: IKK complex
exact_synonym: "I-kappaB kinase complex" []
xref_analog: GO:0008385
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000244
name: cytokeratin 6C
is_a: IMR:0000469 ! cytokeratin 6

[Term]
id: IMR:0000245
name: PKC
exact_synonym: "protein kinase C" []
xref_analog: GO:0004697
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000246
name: nPKC
def: "novel PKC isoforms (delta, epsilon, eta and theta) are regulated by DAG and phospholipids." [PubMed:15282562]
exact_synonym: "novel protein kinase C" []
is_a: IMR:0000245 ! PKC

[Term]
id: IMR:0000247
name: aPKC
def: "atypical PKC isoforms (zeta and lambda/iota; PKC-lambda is the mouse ortholog of human PKC-iota) are insensitive to both calcium and DAG." [PubMed:15282562]
exact_synonym: "atypical protein kinase C" []
xref_analog: GO:0004700
is_a: IMR:0000245 ! PKC

[Term]
id: IMR:0000248
name: RSK
def: "A family of 90 kDa ribosomal S6 kinases (RSK; also known as p90rsk or MAPK-activated protein kinase-1, MAPKAP-K1). The RSK family of kinases includes three isoforms: RSK1, RSK2 and RSK3 that are encoded by distinct genes and show 75-80% amino acid identity. RSK proteins is regulated by the ERK kinase pathway." [PubMed:10411321]
exact_synonym: "90 kDa ribosomal S6 kinase" []
exact_synonym: "MAPK-activated protein kinase-1" []
exact_synonym: "MAPKAP kinase-1" []
exact_synonym: "MAPKAP-K1" []
exact_synonym: "p90rsk" []
xref_analog: GO:0004711
is_a: IMR:0001844 ! S6K
is_a: IMR:0100271 ! MAPKAPK

[Term]
id: IMR:0000249
name: PKA
exact_synonym: "cAMP-dependent protein kinase" []
exact_synonym: "protein kinase A" []
xref_analog: GO:0004691
xref_analog: GO:0005952
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000250
name: Akt
exact_synonym: "PKB" []
exact_synonym: "protein kinase B" []
exact_synonym: "RAC serine/threonine protein kinase" []
exact_synonym: "RAC-PK" []
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000251
name: PKG
exact_synonym: "cGMP-dependent protein kinase" []
xref_analog: GO:0004692
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000252
name: Ste20 homolog family
is_a: IMR:0100207 ! MAPKKKK

[Term]
id: IMR:0000253
name: mammalian Ste20-like kinases (MAPKKKK)
is_a: IMR:0000252 ! Ste20 homolog family

[Term]
id: IMR:0000254
name: G-protein coupled receptor kinase
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000255
name: PDK
alt_id: IMR:0010402
exact_synonym: "3-phosphoinositide dependent protein kinase-1" []
exact_synonym: "hPDK1" []
exact_synonym: "phosphatidylinositol-dependent kinase" []
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000256
name: Plk
exact_synonym: "polo-like kinase" []
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000257
name: GSK3
exact_synonym: "glycogen synthase kinase 3" []
xref_analog: GO:0004696
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000258
name: protein serine/threonine/tyrosine kinase
exact_synonym: "dual specificity kinase" []
xref_analog: GO:0004712
is_a: IMR:0000209 ! protein kinase

[Term]
id: IMR:0000259
name: MAPKK
exact_synonym: "MAP kinase kinase" []
exact_synonym: "MAPK kinase" []
xref_analog: GO:0004708
is_a: IMR:0000258 ! protein serine/threonine/tyrosine kinase

[Term]
id: IMR:0000260
name: cytokeratin 6D
is_a: IMR:0000469 ! cytokeratin 6

[Term]
id: IMR:0000261
name: MEK1/2(MKK1/2)
def: "MEK1 and MEK2 phosphorylate and activate ERK1 and ERK2 MAP kinases." [PubMed:11242034, PubMed:9922370]
exact_synonym: "MAPKK1/2" []
exact_synonym: "MEK" []
exact_synonym: "MEK1/2" []
exact_synonym: "MKK1/2" []
is_a: IMR:0000259 ! MAPKK

[Term]
id: IMR:0000262
name: MKK4/7(JNKK1/2)
def: "MKK4 and MKK7 phosphorylate and activate JNK MAP kinases." [PubMed:11242034, PubMed:9922370]
is_a: IMR:0000259 ! MAPKK

[Term]
id: IMR:0000263
name: MKK3/6
def: "MKK3 and MKK6 phosphorylate and activate p38 MAP kinases." [PubMed:11242034, PubMed:9922370]
is_a: IMR:0000259 ! MAPKK

[Term]
id: IMR:0000264
name: inositol/phosphatidylinositol kinase
xref_analog: GO:0004428
is_a: IMR:0000512 ! kinase

[Term]
id: IMR:0000265
name: PI3-kinase
exact_synonym: "phosphatidylinositol 3-kinase" []
exact_synonym: "PI3K" []
xref_analog: GO:0016303
is_a: IMR:0000264 ! inositol/phosphatidylinositol kinase

[Term]
id: IMR:0000266
name: PI3-kinase p85 subunit
exact_synonym: "Phosphatidylinositol 3-kinase p85 regulatory subunit" []
is_a: IMR:0000429 ! enzyme regulator
relationship: part_of IMR:0000265 ! PI3-kinase

[Term]
id: IMR:0000267
name: PI3-kinase p110 subunit
exact_synonym: "Phosphatidylinositol 3-kinase p110 catalytic subunit" []
is_a: IMR:0000264 ! inositol/phosphatidylinositol kinase
relationship: part_of IMR:0000265 ! PI3-kinase

[Term]
id: IMR:0000268
name: PI5k
is_a: IMR:0000264 ! inositol/phosphatidylinositol kinase

[Term]
id: IMR:0000269
name: RIP
exact_synonym: "Receptor interacting protein" []
exact_synonym: "Receptor-interacting serine/threonine protein kinase" []
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000270
name: cytokeratin 6E
is_a: IMR:0000469 ! cytokeratin 6

[Term]
id: IMR:0000271
name: SHIP
exact_synonym: "Src homology-2 domain-containing inositol 5'-phosphatase" []
is_a: IMR:0100365 ! inositol/phosphatidylinositol phosphatase

[Term]
id: IMR:0000272
name: protein phosphatase
xref_analog: GO:0004721
is_a: IMR:0000517 ! phosphatase

[Term]
id: IMR:0000273
name: protein tyrosine phosphatase
xref_analog: EC:3.1.3.48
xref_analog: GO:0004725
is_a: IMR:0000272 ! protein phosphatase

[Term]
id: IMR:0000274
name: SHP family
is_a: IMR:0100337 ! non-receptor protein tyrosine phosphatase

[Term]
id: IMR:0000275
name: SHP-1
exact_synonym: "HCP" []
exact_synonym: "PTP1C" []
exact_synonym: "SH-PTP1" []
exact_synonym: "Src homology 2-containing protein tyrosine phosphatase-1" []
is_a: IMR:0000274 ! SHP family

[Term]
id: IMR:0000276
name: SHP-2
exact_synonym: "PTP1D" []
exact_synonym: "SH-PTP2" []
exact_synonym: "Src homology 2-containing protein tyrosine phosphatase-2" []
exact_synonym: "Syp" []
is_a: IMR:0000274 ! SHP family

[Term]
id: IMR:0000277
name: protein serine/threonine phosphatase
xref_analog: EC:3.1.3.16
xref_analog: GO:0004722
is_a: IMR:0000272 ! protein phosphatase

[Term]
id: IMR:0000278
name: calcineurin
exact_synonym: "Ca2+/calmodulin-dependent protein phosphatase" []
exact_synonym: "CN" []
exact_synonym: "PP2B" []
exact_synonym: "protein phosphatase type 2B" []
xref_analog: GO:0030357
is_a: IMR:0000277 ! protein serine/threonine phosphatase

[Term]
id: IMR:0000279
name: PP1
xref_analog: GO:0000163
is_a: IMR:0000277 ! protein serine/threonine phosphatase

[Term]
id: IMR:0000280
name: PP2A
exact_synonym: "protein phosphatase 2A" []
xref_analog: GO:0000158
is_a: IMR:0000277 ! protein serine/threonine phosphatase

[Term]
id: IMR:0000281
name: phospholipase
xref_analog: GO:0004620
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0000283
name: PLA2
exact_synonym: "phospholipase A2" []
xref_analog: EC:3.1.1.4
xref_analog: GO:0004623
is_a: IMR:0000281 ! phospholipase

[Term]
id: IMR:0000284
name: PLC
exact_synonym: "phospholipase C" []
xref_analog: EC:3.1.4.11
xref_analog: GO:0004629
is_a: IMR:0000281 ! phospholipase

[Term]
id: IMR:0000285
name: PLC gamma
exact_synonym: "phospholipase C gamma" []
is_a: IMR:0000284 ! PLC

[Term]
id: IMR:0000286
name: PLCbeta
exact_synonym: "phospholipase C beta" []
is_a: IMR:0000284 ! PLC

[Term]
id: IMR:0000287
name: PLD
exact_synonym: "phospholipase D" []
xref_analog: EC:3.1.4.4
xref_analog: GO:0004630
is_a: IMR:0000281 ! phospholipase

[Term]
id: IMR:0000288
name: small GTPase
def: "The RAS superfamily of GTP (guanosine triphosphate) hydrolysis-coupled signal transduction relay proteins can be subclassified into RAS, RHO, RAB, and ARF families, as well as the closely related G alpha family. The members of each family can, in turn, be arranged into evolutionarily conserved branches. These groupings reflect structural, biochemical, and functional conservation." [PubMed:15367757, PubMed:15731001]
exact_synonym: "Ras superfamily" []
exact_synonym: "small G-protein" []
exact_synonym: "small GTP-binding protein" []
xref_analog: EC:3.6.5.2
xref_analog: IPR:001806
is_a: IMR:0000914 ! GTP-binding protein
is_a: IMR:0000960 ! GTPase

[Term]
id: IMR:0000289
name: Ras family
xref_analog: IPR:003577
is_a: IMR:0000288 ! small GTPase

[Term]
id: IMR:0000290
name: Ras
exact_synonym: "Ras GTPase" []
is_a: IMR:0000289 ! Ras family

[Term]
id: IMR:0000291
name: K-Ras
is_a: IMR:0000290 ! Ras

[Term]
id: IMR:0000292
name: R-Ras
exact_synonym: "related to Ras" []
is_a: IMR:0000289 ! Ras family

[Term]
id: IMR:0000293
name: Ral
exact_synonym: "Ras-like" []
is_a: IMR:0000289 ! Ras family

[Term]
id: IMR:0000294
name: Rap
exact_synonym: "Ras proximal" []
is_a: IMR:0000289 ! Ras family

[Term]
id: IMR:0000295
name: Rho family
xref_analog: IPR:003578
is_a: IMR:0000288 ! small GTPase

[Term]
id: IMR:0000296
name: Rho
is_a: IMR:0000295 ! Rho family

[Term]
id: IMR:0000297
name: Rac
is_a: IMR:0000295 ! Rho family

[Term]
id: IMR:0000298
name: Cdc42 (yeast)
comment: This term was made obsolete. To update annotations, consider the term 'IMR0000699:Cdc42'.
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0000299
name: Rab
exact_synonym: "Ras genes from rat brain" []
xref_analog: IPR:003579
is_a: IMR:0000288 ! small GTPase

[Term]
id: IMR:0000300
name: Ran
exact_synonym: "Ras-like nuclear protein" []
exact_synonym: "TC4" []
xref_analog: IPR:002041
is_a: IMR:0000288 ! small GTPase
is_a: IMR:0000653 ! nucleocytoplasmic transport protein

[Term]
id: IMR:0000301
name: Arf/Sar
is_a: IMR:0000288 ! small GTPase

[Term]
id: IMR:0000303
name: Sar
xref_analog: GO:0003932
is_a: IMR:0000301 ! Arf/Sar
is_a: IMR:0000654 ! vesicular transport protein

[Term]
id: IMR:0000304
name: protease
exact_synonym: "peptidase" []
xref_analog: EC:3.4.-.-
xref_analog: GO:0008233
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0000305
name: caspase
xref_analog: GO:0030693
is_a: IMR:0000304 ! protease

[Term]
id: IMR:0000306
name: effector caspase
xref_analog: GO:0004207
is_a: IMR:0000305 ! caspase

[Term]
id: IMR:0000308
name: signaling (initiator) caspase
xref_analog: GO:0004200
is_a: IMR:0000305 ! caspase

[Term]
id: IMR:0000310
name: 26S proteasome
def: "The 26S proteasome is a 2.5-MDa molecular machine built from ~31 different subunits, which catalyzes protein degradation. It contains a barrel-shaped proteolytic core complex (the 20S proteasome), capped at one or both ends by 19S regulatory complexes, which recognize ubiquitinated proteins." [PubMed:10872471, PubMed:9228274, PubMed:9647729]
xref_analog: GO:0000502
is_a: IMR:0000304 ! protease

[Term]
id: IMR:0000311
name: 20S proteasome
exact_synonym: "20S catalytic complex" []
exact_synonym: "20S core particle" []
xref_analog: GO:0005839
relationship: part_of IMR:0000310 ! 26S proteasome

[Term]
id: IMR:0000312
name: 19S regulatory complex
exact_synonym: "PA700 activator" []
xref_analog: GO:0005838
is_a: IMR:0001014 ! proteasome activator subunit
relationship: part_of IMR:0000310 ! 26S proteasome

[Term]
id: IMR:0000313
name: adenylate cyclase
xref_analog: EC:4.6.1.1
xref_analog: GO:0004016
is_a: IMR:0000961 ! cyclase

[Term]
id: IMR:0000314
name: guanylate cyclase
exact_synonym: "guanylyl cyclase" []
xref_analog: EC:4.6.1.2
xref_analog: GO:0004383
is_a: IMR:0000961 ! cyclase

[Term]
id: IMR:0000315
name: trimeric G-protein
exact_synonym: "G-protein" []
exact_synonym: "heterotrimeric G-protein" []
exact_synonym: "trimeric GTP-binding protein" []
is_a: IMR:0000914 ! GTP-binding protein

[Term]
id: IMR:0000316
name: G-alpha
exact_synonym: "G-protein, alpha subunit" []
exact_synonym: "Guanine nucleotide-binding protein, alpha subunit" []
xref_analog: EC:3.6.5.1
is_a: IMR:0000960 ! GTPase
relationship: part_of IMR:0000315 ! trimeric G-protein

[Term]
id: IMR:0000317
name: G-alpha-s class
is_a: IMR:0000316 ! G-alpha

[Term]
id: IMR:0000318
name: G-alpha-i class
is_a: IMR:0000316 ! G-alpha

[Term]
id: IMR:0000319
name: G-alpha-i
is_a: IMR:0000318 ! G-alpha-i class

[Term]
id: IMR:0000320
name: G-alpha-o
is_a: IMR:0000318 ! G-alpha-i class

[Term]
id: IMR:0000321
name: G-alpha-t
exact_synonym: "transducin alpha" []
is_a: IMR:0000318 ! G-alpha-i class

[Term]
id: IMR:0000322
name: G-alpha-z
is_a: IMR:0000318 ! G-alpha-i class

[Term]
id: IMR:0000323
name: G-alpha-q class
is_a: IMR:0000316 ! G-alpha

[Term]
id: IMR:0000324
name: G-alpha-12/13 class
is_a: IMR:0000316 ! G-alpha

[Term]
id: IMR:0000325
name: G-beta
exact_synonym: "G-protein beta subunit" []
is_a: IMR:0000428 ! signal regulator
relationship: part_of IMR:0100018 ! G-betagamma dimers

[Term]
id: IMR:0000326
name: G-gamma
exact_synonym: "G-protein gamma subunit" []
is_a: IMR:0000428 ! signal regulator
relationship: part_of IMR:0100018 ! G-betagamma dimers

[Term]
id: IMR:0000327
name: ubiquitin-activating enzyme (E1)
xref_analog: GO:0004839
is_a: IMR:0000959 ! ubiquitin related enzyme

[Term]
id: IMR:0000328
name: ubiquitin-conjugating enzyme (E2)
xref_analog: GO:0004840
is_a: IMR:0000959 ! ubiquitin related enzyme

[Term]
id: IMR:0000329
name: ubiquitin ligase (E3)
xref_analog: GO:0004842
is_a: IMR:0000959 ! ubiquitin related enzyme
is_a: IMR:0010053 ! ligase

[Term]
id: IMR:0000330
name: deubiquitinating enzyme
def: "Deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin from ubiquitin-conjugated substrate proteins. DUBs constitute large gene families in eukaryotes." [PubMed:12944365, PubMed:15180524]
exact_synonym: "DUB" []
exact_synonym: "ubiquitin-specific protease" []
xref_analog: GO:0004843
is_a: IMR:0000959 ! ubiquitin related enzyme

[Term]
id: IMR:0000331
name: COX
exact_synonym: "prostaglandin endoperoxide synthase" []
xref_analog: EC:1.14.99.1
is_a: IMR:0000952 ! oxidoreductase

[Term]
id: IMR:0000332
name: phosphodiesterase
exact_synonym: "PDE" []
xref_analog: EC:3.1.4.-
xref_analog: GO:0008081
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0000333
name: adaptor/docking/scaffold/anchoring protein
def: "Scaffold,docking, anchoring, and adaptor proteins contribute to the specificity of signal transduction events by recruiting active enzymes into signaling networks or by placing enzymes close to their substrates." [PubMed:9405336]
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000334
name: SH2/SH3 adaptor protein
def: "This term refers to the adaptor proteins that possesses both SH2 and SH3 domains, such as Grb2, Nck and Crk, and does not include adaptor proteins that contain only SH2 or PTB domains, such as the Shc family and the IRS family." [PubMed:10393272]
xref_analog: GO:0005070
is_a: IMR:0000743 ! adaptor protein

[Term]
id: IMR:0000335
name: Crk
def: "Alternative splicing of the mammal crk gene yields two translation products designated the 28-kDa Crk-I and the 42-kDa Crk-II protein. " [PubMed:10393272]
exact_synonym: "CT-10 regulator of kinase" []
exact_synonym: "Proto-oncogene C-crk" []
is_a: IMR:0000745 ! Crk family

[Term]
id: IMR:0000336
name: Crk I
is_a: IMR:0000335 ! Crk

[Term]
id: IMR:0000337
name: Crk-L
exact_synonym: "Crk-like protein" []
is_a: IMR:0000745 ! Crk family

[Term]
id: IMR:0000338
name: Crk II
is_a: IMR:0000335 ! Crk

[Term]
id: IMR:0000339
name: Grb2 family
def: "The best characterised member of the SH2/SH3 adaptor protein family is Grb2, the human homologue of the nematode Caenorhabditis elegans protein Sem-5. The structure of Grb2 consists of one SH2 domain flanked by two SH3 domains. Recently, further members of the Grb2 family have been isolated, Grap protein and Gads." [PubMed:10393272]
is_a: IMR:0000334 ! SH2/SH3 adaptor protein

[Term]
id: IMR:0000340
name: Grb2
alt_id: IMR:0010276
exact_synonym: "abundant Src homology protein" []
exact_synonym: "Ash" []
exact_synonym: "ASH protein" []
exact_synonym: "GRB2 adapter protein" []
exact_synonym: "growth factor receptor bound protein 2" []
exact_synonym: "Growth factor receptor-bound protein 2" []
exact_synonym: "SH2/SH3 adapter GRB2" []
is_a: IMR:0000339 ! Grb2 family

[Term]
id: IMR:0000341
name: Grap
exact_synonym: "Grb2-related adaptor protein" []
is_a: IMR:0000339 ! Grb2 family

[Term]
id: IMR:0000342
name: Nck family
def: "The widely expressed Nck is a 47-kDa cytosolic protein exclusively composed of one SH2 and three SH3 domains. Recently, a second member of the Nck family has been isolated (Nck beta/Grb4) which shows 68% amino acid identity to Nck (Nck alpha)." [PubMed:10393272]
is_a: IMR:0000334 ! SH2/SH3 adaptor protein

[Term]
id: IMR:0000343
name: Nck
alt_id: IMR:0011207
exact_synonym: "Cytoplasmic protein NCK1" []
exact_synonym: "IRS-4a-P" []
exact_synonym: "NCK adaptor protein 1" []
exact_synonym: "Nck alpha" []
exact_synonym: "SH2/SH3 adaptor protein NCK-alpha" []
is_a: IMR:0000342 ! Nck family

[Term]
id: IMR:0000344
name: Nck beta/Grb4
alt_id: IMR:0011208
exact_synonym: "Cytoplasmic protein NCK2" []
exact_synonym: "IRS-4b-P" []
exact_synonym: "NCK adaptor protein 2" []
exact_synonym: "Nck-2" []
exact_synonym: "SH2/SH3 adaptor protein NCK-beta" []
is_a: IMR:0000342 ! Nck family

[Term]
id: IMR:0000345
name: docking protein
def: "Typically, docking proteins have an NH2-terminal membrane-targeting element, either a PH domain or a myristylation site, and a PTB domain that directs association with an NPXY autophosphorylation site on a specific receptor. The kinase domain of the activated receptor phosphorylates Tyr residues in the docking protein that act as docking sites for multiple SH2-domain signaling proteins." [PubMed:11057895, PubMed:9405336]
is_a: IMR:0000743 ! adaptor protein

[Term]
id: IMR:0000346
name: Dok
exact_synonym: "Downstream of tyrosine kinase" []
is_a: IMR:0000345 ! docking protein

[Term]
id: IMR:0000347
name: Shc
exact_synonym: "src homology and collagen" []
is_a: IMR:0000345 ! docking protein

[Term]
id: IMR:0000348
name: LAT
exact_synonym: "linker for activation of T cell" []
is_a: IMR:0000345 ! docking protein

[Term]
id: IMR:0000349
name: Lnk
is_a: IMR:0000345 ! docking protein

[Term]
id: IMR:0000350
name: SLP-76
exact_synonym: "SH2 domain-containing leukocyte protein of 76 kD" []
is_a: IMR:0100258 ! SLP-76 family

[Term]
id: IMR:0000351
name: IRS
exact_synonym: "insulin receptor substrate" []
is_a: IMR:0000345 ! docking protein

[Term]
id: IMR:0000352
name: cytokeratin 9
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000353
name: BLNK/SLP-65
is_a: IMR:0100258 ! SLP-76 family

[Term]
id: IMR:0000354
name: Cas family
exact_synonym: "CRK-associated substrate family" []
is_a: IMR:0000345 ! docking protein

[Term]
id: IMR:0000355
name: p130Cas
exact_synonym: "Cas" []
exact_synonym: "p130 Crk associated substrate" []
is_a: IMR:0000354 ! Cas family

[Term]
id: IMR:0000356
name: Cbl
is_a: IMR:0000743 ! adaptor protein

[Term]
id: IMR:0000357
name: Grb7
exact_synonym: "Growth factor receptor-bound protein 7" []
is_a: IMR:0100382 ! Grb7/10/14 family

[Term]
id: IMR:0000358
name: HS1
exact_synonym: "LckBP1" []
exact_synonym: "SPY75" []
is_a: IMR:0000333 ! adaptor/docking/scaffold/anchoring protein

[Term]
id: IMR:0000359
name: scaffold protein
xref_analog: GO:0030159
is_a: IMR:0000333 ! adaptor/docking/scaffold/anchoring protein

[Term]
id: IMR:0000360
name: PSD95
exact_synonym: "SAP90" []
exact_synonym: "synapse-associated protein 90" []
is_a: IMR:0000359 ! scaffold protein

[Term]
id: IMR:0000361
name: MAP-kinase scaffold protein
xref_analog: GO:0005078
is_a: IMR:0000359 ! scaffold protein

[Term]
id: IMR:0000362
name: cytokeratin 10
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000363
name: cytokeratin 12
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000364
name: cytokeratin 13
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000365
name: cytokeratin 14
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000366
name: cytokeratin 15
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000367
name: cytokeratin 16
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000368
name: transcription factor
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000369
name: transcriptional regulator
exact_synonym: "transcription regulatory factor" []
is_a: IMR:0000368 ! transcription factor

[Term]
id: IMR:0000370
name: SMAD
exact_synonym: "bsp-1" []
exact_synonym: "DPC-4" []
exact_synonym: "dwarfins" []
exact_synonym: "Mad" []
exact_synonym: "MADR" []
exact_synonym: "sma" []
exact_synonym: "Xmad" []
xref_analog: IPR:001132
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000371
name: R-Smad
is_a: IMR:0000370 ! SMAD

[Term]
id: IMR:0000372
name: Co-Smad
is_a: IMR:0000370 ! SMAD

[Term]
id: IMR:0000373
name: I-Smad
is_a: IMR:0000370 ! SMAD
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000374
name: STAT
exact_synonym: "signal tranducers and activators of transcription" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000375
name: STAT1
def: "There are two STAT1 isoforms (STAT1alpha and STAT1beta) produced by alternative splicing of a single mRNA." [PubMed:1105043]
exact_synonym: "signal transducer and activator of transcription 1" []
is_a: IMR:0000374 ! STAT
relationship: part_of IMR:0001422 ! ISGF3
relationship: part_of IMR:0001423 ! GAF

[Term]
id: IMR:0000376
name: STAT2
exact_synonym: "signal transducer and activator of transcription 2" []
is_a: IMR:0000374 ! STAT
relationship: part_of IMR:0001422 ! ISGF3

[Term]
id: IMR:0000377
name: STAT3
exact_synonym: "signal transducer and activator of transcription 3" []
is_a: IMR:0000374 ! STAT

[Term]
id: IMR:0000378
name: STAT4
exact_synonym: "signal transducer and activator of transcription 4" []
is_a: IMR:0000374 ! STAT

[Term]
id: IMR:0000379
name: STAT5a
exact_synonym: "signal transducer and activator of transcription 5a" []
is_a: IMR:0100733 ! STAT5

[Term]
id: IMR:0000380
name: STAT5b
exact_synonym: "signal transducer and activator of transcription 5b" []
is_a: IMR:0100733 ! STAT5

[Term]
id: IMR:0000381
name: STAT6
exact_synonym: "signal transducer and activator of transcription 6" []
is_a: IMR:0000374 ! STAT

[Term]
id: IMR:0000382
name: NF-kappaB
def: "Members of this family include p50, p52, p65, c-Rel, v-Rrel, RelB, and the Drosophila proteins, Dorsal, Dif and Relish. Most of these transcription factors bind as homo- and heterodimers to the consensus a DNA sequence motif termed kappa-B." [IPR:000451]
exact_synonym: "NF-kappa-B" []
exact_synonym: "NFkB" []
exact_synonym: "nuclear factor-kappa B" []
exact_synonym: "Rel/NF-kappaB family" []
xref_analog: IPR:000451
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000383
name: Myc
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000384
name: Max
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000385
name: Mad
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000386
name: IRF family
exact_synonym: "interferon regulatory factor family" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000387
name: IRF-1
exact_synonym: "interferon regulatory factor-1" []
is_a: IMR:0000386 ! IRF family

[Term]
id: IMR:0000388
name: IRF-2
exact_synonym: "interferon regulatory factor-2" []
is_a: IMR:0000386 ! IRF family

[Term]
id: IMR:0000389
name: IRF-3
is_a: IMR:0000386 ! IRF family

[Term]
id: IMR:0000390
name: IRF-4
is_a: IMR:0000386 ! IRF family

[Term]
id: IMR:0000391
name: IRF-5
is_a: IMR:0000386 ! IRF family

[Term]
id: IMR:0000392
name: IRF-6
is_a: IMR:0000386 ! IRF family

[Term]
id: IMR:0000393
name: IRF-7
is_a: IMR:0000386 ! IRF family

[Term]
id: IMR:0000394
name: ICSBP
is_a: IMR:0000386 ! IRF family

[Term]
id: IMR:0000395
name: p48
exact_synonym: "IRF9" []
exact_synonym: "ISGF3 gamma" []
is_a: IMR:0000386 ! IRF family
relationship: part_of IMR:0001422 ! ISGF3

[Term]
id: IMR:0000396
name: DRTF1/E2F
def: "The members of two distinct families of proteins, DP and E2F, interact combinatorially as DP/E2F heterodimers in DRTF1/E2F transcription factor." [PubMed:7880534]
exact_synonym: "defferentiation-regulated transcription factor 1" []
exact_synonym: "E2 promoter binding factor" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000397
name: ets
exact_synonym: "E26 transformation-specific" []
xref_analog: IPR:000418
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000398
name: ERG
exact_synonym: "ets-related gene" []
is_a: IMR:0000397 ! ets

[Term]
id: IMR:0000399
name: ETS1
exact_synonym: "E26 transformation-specific1" []
is_a: IMR:0000397 ! ets

[Term]
id: IMR:0000400
name: ETS2
exact_synonym: "E26 transformation-specific2" []
is_a: IMR:0000397 ! ets

[Term]
id: IMR:0000401
name: WT1
exact_synonym: "Wilms' tumor protein" []
is_a: IMR:0000369 ! transcriptional regulator
is_a: IMR:0000424 ! transcriptional co-activator

[Term]
id: IMR:0000402
name: EGR family
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000403
name: EGR1
exact_synonym: "Krox24" []
exact_synonym: "NGFI-A" []
exact_synonym: "pAT225" []
exact_synonym: "TIS8" []
exact_synonym: "Zif268" []
is_a: IMR:0000402 ! EGR family

[Term]
id: IMR:0000404
name: EGR2
exact_synonym: "Krox20" []
exact_synonym: "pAT591" []
is_a: IMR:0000402 ! EGR family

[Term]
id: IMR:0000405
name: EGR3
is_a: IMR:0000402 ! EGR family

[Term]
id: IMR:0000406
name: EGR4
exact_synonym: "NGFI-C" []
exact_synonym: "pAT133" []
is_a: IMR:0000402 ! EGR family

[Term]
id: IMR:0000408
name: Myb
exact_synonym: "c-Myb" []
is_a: IMR:0000868 ! Myb family

[Term]
id: IMR:0000409
name: NF1
def: "The NFI family is composed of four members in vertebrates (NFI-A, NFI-B, NFI-C and NFI-X)." [PubMed:10831836]
exact_synonym: "CCAAT box-binding transcription factor" []
exact_synonym: "CTF" []
exact_synonym: "NFI" []
exact_synonym: "nuclear factor 1" []
xref_analog: IPR:000647
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000410
name: GATA
def: "GATA proteins, which control differentiation in a wide variety of cell types, may represent a class of factors that regulate early endoderm development throughout the animal kingdom." [PubMed:12221001]
exact_synonym: "GATA transcription factors" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000411
name: Maf
exact_synonym: "musculoaponeurotic fibrosarcoma" []
xref_analog: IPR:004826
is_a: IMR:0000369 ! transcriptional regulator
relationship: part_of IMR:0000414 ! AP-1

[Term]
id: IMR:0000412
name: PEBP2/CBF
def: "The PEBP2/CBF is a heterodimer  consists of DNA binding  alpha subunits and a beta subunit (CBFbeta) that does not bind DNA directly but that enhances the binding of the alpha subunit. Multiple alpha subunit genes, including CBFA1, AML1 (CBFA2), and CBFA3, have been detected.  All of the CBFalpha proteins contain a runt domain, which is similar to the Drosophila pair-rule gene, runt." [PubMed:9226149]
exact_synonym: "polyomavirus enhancer binding protein 2/core-binding factor" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000413
name: cytokeratin 17
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000414
name: AP-1
def: "The AP-1 (activator protein 1) transcription factor is a dimeric complex that comprises members of the JUN, FOS, ATF (activating transcription factor) and MAF (musculoaponeurotic fibrosarcoma) protein families. The AP-1 complex can therefore form many different combinations of heterodimers and homodimers, and this combination determines the genes that are regulated by AP-1" [PubMed:14668816]
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000415
name: FOS
xref_analog: IPR:000837
is_a: IMR:0000369 ! transcriptional regulator
relationship: part_of IMR:0000414 ! AP-1

[Term]
id: IMR:0000416
name: JUN
xref_analog: IPR:002112
is_a: IMR:0000369 ! transcriptional regulator
relationship: part_of IMR:0000414 ! AP-1

[Term]
id: IMR:0000417
name: BCL-6
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000418
name: TCF/LEF-1 family
exact_synonym: "T-cell factor/lymphoid-enhancer factor" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000419
name: PRDII-BF1
exact_synonym: "binding factor of PRDII (positive regulatory domainII of the human IFN-beta gene promoter)" []
exact_synonym: "HIV-EP1" []
exact_synonym: "MBP1" []
exact_synonym: "Shn-1" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000420
name: CREB
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000421
name: NF-AT
def: "NFAT proteins are a family of transcription factors (NFATC1~C4) whose activation is controlled by calcineurin, a Ca2+-dependent phosphatase. " [PubMed:11877454, PubMed:11983154]
exact_synonym: "Nuclear factor of activated T-cells" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000422
name: C/EBP
exact_synonym: "CCAAT/enhancer binding protein" []
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000423
name: transcriptional cofactor
xref_analog: GO:0003712
is_a: IMR:0000368 ! transcription factor

[Term]
id: IMR:0000424
name: transcriptional co-activator
xref_analog: GO:0003713
is_a: IMR:0000423 ! transcriptional cofactor

[Term]
id: IMR:0000425
name: Tax
exact_synonym: "transcriptional trans-activator coded in X-region" []
is_a: IMR:0000424 ! transcriptional co-activator

[Term]
id: IMR:0000426
name: p300/CBP
is_a: IMR:0000424 ! transcriptional co-activator
is_a: IMR:0001176 ! histone acetyltransferase

[Term]
id: IMR:0000427
name: transcription co-repressor
xref_analog: GO:0003714
is_a: IMR:0000423 ! transcriptional cofactor

[Term]
id: IMR:0000428
name: signal regulator
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000429
name: enzyme regulator
xref_analog: GO:0030234
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000430
name: RGS family
comment: This term was made obsolete. To update annotations, consider the term 'IMR0000431:RGS'.
exact_synonym: "regulator of G protein signaling family" []
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0000431
name: RGS
def: "RGS proteins act as negative regulators of G protein dependent signaling, at least in part, because they stimulate hydrolysis of the GTP bound to activated G alpha subunits." [PubMed:9064301]
exact_synonym: "regulator of G protein signaling" []
xref_analog: GO:0016299
is_a: IMR:0000429 ! enzyme regulator

[Term]
id: IMR:0000432
name: Axin
exact_synonym: "Axin/conductin" []
is_a: IMR:0000359 ! scaffold protein
is_a: IMR:0001160 ! negative regulator of Wnt signaling pathway

[Term]
id: IMR:0000433
name: GEF
exact_synonym: "guanine nucleotide exchange factor" []
xref_analog: GO:0005085
is_a: IMR:0000429 ! enzyme regulator

[Term]
id: IMR:0000434
name: Vav
is_a: IMR:0001954 ! RhoGEF

[Term]
id: IMR:0000435
name: Sos
def: "Drosophila Son of Sevenless (SOS) is homologous to the yeast exchange factor for Ras, CDC25. Mammalian cells contain two closely related homologs of Drosophila SOS: SOS1 and SOS2. Biochemical studies have established that SOS indeed functions as a guanine nucleotide exchange factor for Ras." [UniProt:12177507]
exact_synonym: "son of sevenless" []
is_a: IMR:0100440 ! RasGEF

[Term]
id: IMR:0000436
name: C3G
exact_synonym: "Crk SH3 domein binding GEF" []
exact_synonym: "Guanine nucleotide-releasing factor 2" []
is_a: IMR:0100440 ! RasGEF

[Term]
id: IMR:0000437
name: Dbl
is_a: IMR:0001954 ! RhoGEF

[Term]
id: IMR:0000438
name: cytohesin
is_a: IMR:0000433 ! GEF

[Term]
id: IMR:0000439
name: RalGEF
exact_synonym: "Ral guanine nucleotide exchange factor" []
xref_analog: GO:0008321
is_a: IMR:0100440 ! RasGEF

[Term]
id: IMR:0000440
name: RasGRF
is_a: IMR:0100440 ! RasGEF

[Term]
id: IMR:0000441
name: TAB1
exact_synonym: "TAK1 binding protein 1" []
is_a: IMR:0002665 ! TAB

[Term]
id: IMR:0000442
name: GAP
exact_synonym: "GTPase activating protein" []
xref_analog: GO:0005096
is_a: IMR:0000429 ! enzyme regulator

[Term]
id: IMR:0000443
name: Ras GAP
exact_synonym: "Ras GTPase-activating protein" []
xref_analog: GO:0005099
is_a: IMR:0000442 ! GAP

[Term]
id: IMR:0000444
name: GDI
exact_synonym: "GDP-dissociation inhibitor" []
exact_synonym: "guanine nucleotide dissociation inhibitor" []
xref_analog: GO:0005092
is_a: IMR:0000429 ! enzyme regulator

[Term]
id: IMR:0000445
name: CKI
exact_synonym: "cyclin-dependent kinase inhibitor" []
exact_synonym: "cyclin-dependent protein kinase inhibitor" []
xref_analog: GO:0004861
is_a: IMR:0000429 ! enzyme regulator

[Term]
id: IMR:0000446
name: Cip/Kip family
is_a: IMR:0000445 ! CKI

[Term]
id: IMR:0000447
name: INK4 family
is_a: IMR:0000445 ! CKI

[Term]
id: IMR:0000448
name: Noggin
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000449
name: sina/siah
exact_synonym: "seven in absentia/sina homolog" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000450
name: apoptosis regulator
xref_analog: GO:0016329
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000451
name: Bcl-2 family
def: "The Bcl-2 family consists of about 20 homologues of important pro- and anti-apoptotic regulators of programmed cell death." [PubMed:14634621, PubMed:14996506]
exact_synonym: "B cell lymphoma/leukemia-2 family" []
is_a: IMR:0000450 ! apoptosis regulator

[Term]
id: IMR:0000452
name: BAK
is_a: IMR:0100708 ! Bax subfamily

[Term]
id: IMR:0000453
name: BAX
is_a: IMR:0100708 ! Bax subfamily

[Term]
id: IMR:0000454
name: IAP-family
exact_synonym: "inhibitor of apoptosis-family" []
is_a: IMR:0000450 ! apoptosis regulator

[Term]
id: IMR:0000455
name: IAP (DROME)
comment: This term was made obsolete. To update annotations, consider the term 'IMR0000454:IAP-family'.
exact_synonym: "inhibitor of apoptosis protein" []
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0000456
name: 14-3-3
def: "The term 14-3-3 denotes a large family of ~30 kDa acidic proteins that exist primarily as homo- and heterodimers within all eukaryotic cells. Their unusual name refers to their elution position on DEAE-cellulose chromatography and gel electrophoresis during a systematic attempt at classifying bovine brain proteins. In humans, there are seven distinct 14-3-3 genes denoted beta, gamma, epsilon, eta, sigma, tau (theta) and zeta (as well as a number of potential pseudogenes), while yeast and plants contain between 2 and 15 genes." [PubMed:11911880]
xref_analog: IPR:000308
is_a: IMR:0000428 ! signal regulator
is_a: IMR:0001160 ! negative regulator of Wnt signaling pathway

[Term]
id: IMR:0000457
name: calmodulin
alt_id: IMR:0010172
exact_synonym: "CALM" []
exact_synonym: "Calmodulin" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000458
name: cytokeratin 18
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000459
name: cytokeratin 19
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000460
name: SOCS
exact_synonym: "CIS" []
exact_synonym: "Cytokine-inducible SH2 protein" []
exact_synonym: "SSI" []
exact_synonym: "STAT induced STAT inhibitor" []
exact_synonym: "Suppressor of cytokine signaling" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000461
name: pRB
exact_synonym: "Retinoblastoma protein" []
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000462
name: TRAF family
exact_synonym: "TNF receptor associated factor family" []
is_a: IMR:0000743 ! adaptor protein

[Term]
id: IMR:0000463
name: I-kappaB family
is_a: IMR:0000428 ! signal regulator

[Term]
id: IMR:0000464
name: I-kappaB
exact_synonym: "IkB" []
exact_synonym: "inhibitor of NF-kappaB" []
is_a: IMR:0000463 ! I-kappaB family

[Term]
id: IMR:0000465
name: antigen
is_a: IMR:0000002 ! ligand

[Term]
id: IMR:0000466
name: cytokeratin 20
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000467
name: cytokeratin 23
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000469
name: cytokeratin 6
is_a: IMR:0000050 ! type II cytokeratin

[Term]
id: IMR:0000470
name: K2C6A_MOUSE
exact_synonym: "CK 6A" [UniProt:P50446]
exact_synonym: "Cytokeratin-6A" [UniProt:P50446]
exact_synonym: "K6a keratin" [UniProt:P50446]
exact_synonym: "Ker2" [UniProt:P50446]
exact_synonym: "keratin 6A" [MGI:1100845]
exact_synonym: "Keratin, type II cytoskeletal 6A" [UniProt:P50446]
exact_synonym: "Keratin-6 alpha" [UniProt:P50446]
exact_synonym: "Krt2-6" [UniProt:P50446]
exact_synonym: "Krt2-6a" [UniProt:P50446, MGI:1100845]
exact_synonym: "Krt2-6c" [MGI:1100845]
exact_synonym: "Krt6" [UniProt:P50446]
exact_synonym: "Krt6a" [UniProt:P50446, MGI:1100845]
exact_synonym: "mK6-alpha" [UniProt:P50446]
exact_synonym: "mK6[a]" [MGI:1100845]
exact_synonym: "MK6a" [MGI:1100845]
xref_analog: UniProt:P50446
relationship: sequence_of IMR:0000165 ! cytokeratin 6A

[Term]
id: IMR:0000471
name: cytokeratin 21
is_a: IMR:0000035 ! type I cytokeratin

[Term]
id: IMR:0000472
name: NF-H
is_a: IMR:0000203 ! neurofilament protein

[Term]
id: IMR:0000473
name: CD28
def: "CD28 is an integral membrane protein homodimer, the extracellular region of which contains one immunoglobulin-like domain. In human T cells, CD28 and the T-cell receptor (TCR) are expressed at ~6  104 and ~2  104 molecules per cell, respectively.CD28 is expressed by most mouse T cells, 90% of human CD4+ T cells and 50% of human CD8+ T cells." [PubMed:14647476]
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000474
name: NF-L
is_a: IMR:0000203 ! neurofilament protein

[Term]
id: IMR:0000475
name: NF-M
is_a: IMR:0000203 ! neurofilament protein

[Term]
id: IMR:0000477
name: actin cross linking protein
exact_synonym: "actin bundling protein" []
is_a: IMR:0000188 ! microfilament cytoskeletal protein

[Term]
id: IMR:0000478
name: fimbrin
is_a: IMR:0000477 ! actin cross linking protein

[Term]
id: IMR:0000479
name: alpha-actinin 1
is_a: IMR:0000189 ! alpha-actinin

[Term]
id: IMR:0000480
name: chloride channel
xref_analog: GO:0005254
is_a: IMR:0000482 ! anion channel

[Term]
id: IMR:0000481
name: ion channel
xref_analog: GO:0005216
is_a: IMR:0000655 ! channel

[Term]
id: IMR:0000482
name: anion channel
xref_analog: GO:0005253
is_a: IMR:0000481 ! ion channel

[Term]
id: IMR:0000483
name: alpha-actinin 2
is_a: IMR:0000189 ! alpha-actinin

[Term]
id: IMR:0000484
name: alpha-actinin 3
is_a: IMR:0000189 ! alpha-actinin

[Term]
id: IMR:0000485
name: alpha-actinin 4
is_a: IMR:0000189 ! alpha-actinin

[Term]
id: IMR:0000486
name: beta-actin
exact_synonym: "cytoplasmic actin" []
is_a: IMR:0000190 ! actin

[Term]
id: IMR:0000487
name: alpha-cardiac actin
exact_synonym: "cardiac muscle actin" []
is_a: IMR:0000490 ! alpha-actin

[Term]
id: IMR:0000488
name: gamma-actin
is_a: IMR:0000190 ! actin

[Term]
id: IMR:0000489
name: alpha-actin 1
exact_synonym: "skeletal muscle alpha-actin" []
is_a: IMR:0000490 ! alpha-actin

[Term]
id: IMR:0000490
name: alpha-actin
is_a: IMR:0000190 ! actin

[Term]
id: IMR:0000491
name: alpha-actin 3
exact_synonym: "gamma-actin 2" []
exact_synonym: "gamma-enteric actin" []
exact_synonym: "smooth muscle (enteric type) gamma-actin" []
exact_synonym: "smooth muscle gamma-actin" []
is_a: IMR:0000490 ! alpha-actin

[Term]
id: IMR:0000492
name: alpha-actin 2
exact_synonym: "smooth muscle alpha-actin (aortic type)" []
is_a: IMR:0000490 ! alpha-actin

[Term]
id: IMR:0000494
name: microfilament protein
exact_synonym: "actin filament protein" []
xref_analog: GO:0005884
is_a: IMR:0000188 ! microfilament cytoskeletal protein

[Term]
id: IMR:0000495
name: microtubule protein
xref_analog: GO:0005874
is_a: IMR:0000196 ! microtubule cytoskeletal protein

[Term]
id: IMR:0000496
name: intermediate filament protein
xref_analog: GO:0005882
is_a: IMR:0000201 ! intermediate filament cytoskeletal protein

[Term]
id: IMR:0000497
name: sodium channel
xref_analog: GO:0005272
is_a: IMR:0000498 ! cation channel

[Term]
id: IMR:0000498
name: cation channel
xref_analog: GO:0005261
is_a: IMR:0000481 ! ion channel

[Term]
id: IMR:0000499
name: calcium channel
xref_analog: GO:0005262
is_a: IMR:0000498 ! cation channel

[Term]
id: IMR:0000500
name: potassium channel
xref_analog: GO:0005267
is_a: IMR:0000498 ! cation channel

[Term]
id: IMR:0000501
name: Ca2+-sensitive potassium channel
exact_synonym: "Calcium-activated potassium channel" []
xref_analog: GO:0015269
is_a: IMR:0000500 ! potassium channel
is_a: IMR:0000746 ! intracellular ligand-gated ion channel

[Term]
id: IMR:0000502
name: inward rectifier potassium channel
exact_synonym: "Kir" []
xref_analog: GO:0005242
is_a: IMR:0000500 ! potassium channel

[Term]
id: IMR:0000503
name: Kir1
is_a: IMR:0000502 ! inward rectifier potassium channel

[Term]
id: IMR:0000504
name: Kir1.1
is_a: IMR:0000503 ! Kir1

[Term]
id: IMR:0000505
name: Kir2
is_a: IMR:0000502 ! inward rectifier potassium channel

[Term]
id: IMR:0000506
name: Kir2.1
is_a: IMR:0000505 ! Kir2

[Term]
id: IMR:0000507
name: Kir2.2
is_a: IMR:0000505 ! Kir2

[Term]
id: IMR:0000508
name: Kir3
is_a: IMR:0000502 ! inward rectifier potassium channel

[Term]
id: IMR:0000509
name: Kir5
is_a: IMR:0000502 ! inward rectifier potassium channel

[Term]
id: IMR:0000510
name: Kir6
is_a: IMR:0000502 ! inward rectifier potassium channel

[Term]
id: IMR:0000511
name: Kir7
is_a: IMR:0000502 ! inward rectifier potassium channel

[Term]
id: IMR:0000512
name: kinase
xref_analog: EC:2.7.-.-
xref_analog: GO:0016301
is_a: IMR:0010050 ! transferase

[Term]
id: IMR:0000513
name: voltage-gated potassium channel
xref_analog: GO:0005249
is_a: IMR:0000500 ! potassium channel
is_a: IMR:0100584 ! voltage-gated ion channel

[Term]
id: IMR:0000515
name: caveolin
is_a: IMR:0000333 ! adaptor/docking/scaffold/anchoring protein

[Term]
id: IMR:0000516
name: clathrin
is_a: IMR:0000654 ! vesicular transport protein

[Term]
id: IMR:0000517
name: phosphatase
exact_synonym: "phosphoric monoester hydrolase activity" []
xref_analog: EC:3.1.3.-
xref_analog: GO:0016791
is_a: IMR:0010044 ! hydrolase

[Term]
id: IMR:0000518
name: motor protein
exact_synonym: "molecular motor" []
xref_analog: GO:0003774
is_a: IMR:0000185 ! cytoskeletal protein

[Term]
id: IMR:0000519
name: Kv
def: "The Kv family can be divided into 4 subfamilies on the basis of sequence similarity and function: Shaker (Kv1), Shab (Kv2), Shaw (Kv3) and Shal (Kv4)." [ISBN:0121844536]
xref_analog: IPR:003968
is_a: IMR:0000513 ! voltage-gated potassium channel

[Term]
id: IMR:0000520
name: arrestin
is_a: IMR:0000950 ! cellular structure protein

[Term]
id: IMR:0000522
name: Aquaporin
is_a: IMR:0000656 ! water channel

[Term]
id: IMR:0000523
name: COP I vesicle protein
is_a: IMR:0000654 ! vesicular transport protein

[Term]
id: IMR:0000524
name: Kv1-Shaker
def: "Vertebrate K+ channel subunits whose primary amino acid sequences are most closely related to those of Drosophila Shaker are grouped in the voltage-gated K+ channel subfamily 1 (Kv1)." [ISBN:0121844536]
xref_analog: IPR:003972
is_a: IMR:0000519 ! Kv

[Term]
id: IMR:0000525
name: coatomer protein complex
xref_analog: GO:0030126
is_a: IMR:0000523 ! COP I vesicle protein

[Term]
id: IMR:0000526
name: connexin
is_a: IMR:0000950 ! cellular structure protein

[Term]
id: IMR:0000527
name: Kv1.1
is_a: IMR:0000524 ! Kv1-Shaker

[Term]
id: IMR:0000528
name: Kv1.2
is_a: IMR:0000524 ! Kv1-Shaker

[Term]
id: IMR:0000529
name: Kv1.3
is_a: IMR:0000524 ! Kv1-Shaker

[Term]
id: IMR:0000530
name: Kv1.4
is_a: IMR:0000524 ! Kv1-Shaker

[Term]
id: IMR:0000531
name: Kv1.5
is_a: IMR:0000524 ! Kv1-Shaker

[Term]
id: IMR:0000532
name: Kv1.6
is_a: IMR:0000524 ! Kv1-Shaker

[Term]
id: IMR:0000533
name: Kv2-Shab
def: "Vertebrate K+ channel subunits whose primary amino acid sequences are most closely related to those of Drosophila Shab are grouped in the voltage-gated K+ channel subfamily 2 (Kv2)." [ISBN:0121844536]
xref_analog: IPR:003973
is_a: IMR:0000519 ! Kv

[Term]
id: IMR:0000534
name: Kv2.1
is_a: IMR:0000533 ! Kv2-Shab

[Term]
id: IMR:0000535
name: myelin protein
is_a: IMR:0000950 ! cellular structure protein

[Term]
id: IMR:0000537
name: Kv2.2
is_a: IMR:0000533 ! Kv2-Shab

[Term]
id: IMR:0000538
name: Kv3-Shaw
def: "Vertebrate K+ channel subunits whose primary amino acid sequences are most closely related to those of Drosophila Shaw are grouped in the voltage-gated K+ channel subfamily 3 (Kv3)." [ISBN:0121844536]
xref_analog: IPR:003974
is_a: IMR:0000519 ! Kv

[Term]
id: IMR:0000540
name: extracellular matrix protein
exact_synonym: "ECM protein" []
xref_analog: GO:0005201
xref_analog: GO:0005578
is_a: IMR:0000950 ! cellular structure protein

[Term]
id: IMR:0000541
name: collagen
xref_analog: GO:0005581
is_a: IMR:0000540 ! extracellular matrix protein

[Term]
id: IMR:0000542
name: fibrillar collagen
def: "Types I, II and III collagens constitute the classical fibrillar collagens and account for 80-90% of all the collagen in the body. Types V and XI collagens are also classified as fibrillar collagens on the basis of thier homology with types I-III collagens." [ISBN:0120689111]
exact_synonym: "fibrillar forming collagen" []
xref_analog: GO:0005583
is_a: IMR:0000541 ! collagen

[Term]
id: IMR:0000544
name: fibril-associated collagen
def: "associate with the surface of fibrils and modify their interactive properties." [ISBN:0120689111]
exact_synonym: "FACIT collagen" []
exact_synonym: "fibril associated collagens with interrupted triple helix" []
xref_analog: GO:0005593
is_a: IMR:0000541 ! collagen

[Term]
id: IMR:0000546
name: fibronectin
is_a: IMR:0000540 ! extracellular matrix protein

[Term]
id: IMR:0000547
name: elastin
is_a: IMR:0000540 ! extracellular matrix protein

[Term]
id: IMR:0000548
name: tenascin
is_a: IMR:0000540 ! extracellular matrix protein

[Term]
id: IMR:0000549
name: Kv3.1
is_a: IMR:0000538 ! Kv3-Shaw

[Term]
id: IMR:0000550
name: Kv3.2
is_a: IMR:0000538 ! Kv3-Shaw

[Term]
id: IMR:0000551
name: type IV collagen
xref_analog: GO:0005587
is_a: IMR:0001124 ! basement membrane collagen

[Term]
id: IMR:0000552
name: proteoglycan
def: "Proteoglycans are a diverse family of molecules characterized by a core protein to which is attached one or more glycosaminoglycan (GAG) side-chains." [ISBN:0120689111]
is_a: IMR:0000540 ! extracellular matrix protein

[Term]
id: IMR:0000553
name: Kv3.3
is_a: IMR:0000538 ! Kv3-Shaw

[Term]
id: IMR:0000554
name: laminin family
is_a: IMR:0000540 ! extracellular matrix protein

[Term]
id: IMR:0000555
name: kalinin
is_a: IMR:0000554 ! laminin family

[Term]
id: IMR:0000556
name: unclassified protein
is_a: IMR:0000949 ! protein

[Term]
id: IMR:0000557
name: nucleophosmin
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0000558
name: disabled
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0000559
name: GADD45
def: "The MyD118/CR6/Gadd45 gene family (also termed Gadd45b, Gadd45g, Gadd45a) encodes for small (18 kd), evolutionary conserved proteins that are highly homologous to each other (55 57% overall identity at the amino acid level), are highly acidic (pI=4.0  4.2), and are primarily localized within the cell nucleus. MyD118/CR6/GADD45 serve similar, but not identical, functions along different apoptotic and growth inhibitory pathways. They interact with cell cycle proteins." [PubMed:12032777]
exact_synonym: "growth arrest and DNA damage inducible 45" []
is_a: IMR:0000556 ! unclassified protein

[Term]
id: IMR:0000560
name: presenilin
is_a: IMR:0000304 ! protease
relationship: part_of IMR:0001882 ! gamma-secretase complex

[Term]
id: IMR:0000561
name: Kv3.4
is_a: IMR:0000538 ! Kv3-Shaw

[Term]
id: IMR:0000562
name: Kv4-Shal
def: "Vertebrate K+ channel subunits whose primary amino acid sequences are most closely related to those of Drosophila Shal are grouped in the voltage-gated K+ channel subfamily 4 (Kv4)." [ISBN:0121844536]
xref_analog: IPR:003975
is_a: IMR:0000519 ! Kv

[Term]
id: IMR:0000563
name: Kv4.1
is_a: IMR:0000562 ! Kv4-Shal

[Term]
id: IMR:0000564
name: Kv4.2
is_a: IMR:0000562 ! Kv4-Shal

[Term]
id: IMR:0000565
name: Kv4.3
is_a: IMR:0000562 ! Kv4-Shal

[Term]
id: IMR:0000566
name: Dok1
alt_id: IMR:0010219
alt_id: IMR:0011551
exact_synonym: "a p62 rasGAP-associated protein" []
exact_synonym: "Downstream of tyrosine kinase 1" []
is_a: IMR:0000346 ! Dok

[Term]
id: IMR:0000567
name: Dok2
exact_synonym: "dok-R" []
exact_synonym: "Downstream of tyrosine kinase 2" []
exact_synonym: "FRIP" []
is_a: IMR:0000346 ! Dok

[Term]
id: IMR:0000568
name: P-cadherin
exact_synonym: "cadherin-3" []
exact_synonym: "Placental-cadherin" []
is_a: IMR:0000167 ! cadherin

[Term]
id: IMR:0000569
name: K-cadherin
exact_synonym: "cadherin-6" []
exact_synonym: "Kidney-cadherin" []
is_a: IMR:0000167 ! cadherin

[Term]
id: IMR:0000570
name: ponsin-1
is_a: IMR:0000184 ! ponsin

[Term]
id: IMR:0000571
name: ponsin-2
is_a: IMR:0000184 ! ponsin

[Term]
id: IMR:0000572
name: IFN alpha-1
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000573
name: IFN alpha-2
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000574
name: IFN alpha-4
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000575
name: IFN alpha-5
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000576
name: IFN alpha-6
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000577
name: IFN alpha-7
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000578
name: IFN alpha-8
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000579
name: IFN alpha-9
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000580
name: IFN alpha-10
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000581
name: IFN alpha-14
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000582
name: IFN alpha-16
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000583
name: IFN alpha-17
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000584
name: IFN alpha-21
is_a: IMR:0100386 ! IFN alpha

[Term]
id: IMR:0000585
name: IL-4
exact_synonym: "interleukin-4" []
xref_analog: GO:0005136
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000586
name: IL-7
exact_synonym: "interleukin-7" []
xref_analog: GO:0005139
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000587
name: IL-8
exact_synonym: "interleukin-8" []
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000588
name: IL-9
exact_synonym: "interleukin-9" []
xref_analog: GO:0005140
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000589
name: IL-10
exact_synonym: "interleukin-10" []
xref_analog: GO:0005141
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000590
name: IL-12
exact_synonym: "interleukin-12" []
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000591
name: IL-12A
exact_synonym: "interleukin-12 alpha chain" []
exact_synonym: "p35" []
relationship: part_of IMR:0000590 ! IL-12

[Term]
id: IMR:0000592
name: IL-12B
exact_synonym: "interleukin-12 beta chain" []
exact_synonym: "p40" []
relationship: part_of IMR:0000590 ! IL-12

[Term]
id: IMR:0000593
name: IL-1RI : IL-1R AcP
is_a: IMR:0000120 ! IL-1R

[Term]
id: IMR:0000594
name: IL-1RII : IL-1R AcP
is_a: IMR:0000120 ! IL-1R

[Term]
id: IMR:0000595
name: IL-13
exact_synonym: "interleukin-13" []
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000596
name: IL-14
exact_synonym: "High molecular weight B-cell growth factor" []
exact_synonym: "interleukin-14" []
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000597
name: IL-15
exact_synonym: "interleukin-15" []
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000598
name: IL-16
exact_synonym: "interleukin-16" []
exact_synonym: "LCF" []
exact_synonym: "lymphocyte chemoattractant factor" []
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000599
name: IL-17
exact_synonym: "CTLA-8" []
exact_synonym: "cytotoxic T lymphocyte-associated antigen 8" []
exact_synonym: "interleukin-17" []
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000600
name: IL-17R
exact_synonym: "interleukin-17 receptor" []
xref_analog: GO:0030368
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000601
name: IL-18
exact_synonym: "interleukin-18" []
is_a: IMR:0000007 ! Interleukin

[Term]
id: IMR:0000602
name: IL-12R
exact_synonym: "interleukin-12 receptor" []
xref_analog: GO:0016517
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000603
name: IL-12R-beta1
exact_synonym: "interleukin-12 receptor beta-1" []
relationship: part_of IMR:0000602 ! IL-12R

[Term]
id: IMR:0000604
name: IL-12R-beta2
exact_synonym: "interleukin-12 receptor beta-2" []
relationship: part_of IMR:0000602 ! IL-12R

[Term]
id: IMR:0000605
name: IL-8R
exact_synonym: "interleukin-8 receptor" []
xref_analog: GO:0004918
is_a: IMR:0000096 ! interleukin receptor
is_a: IMR:0000137 ! G-Protein Coupled Receptor

[Term]
id: IMR:0000606
name: IL-8RA
exact_synonym: "interleukin-8 receptor A" []
is_a: IMR:0000605 ! IL-8R

[Term]
id: IMR:0000607
name: IL-8RB
exact_synonym: "interleukin-8 receptor B" []
is_a: IMR:0000605 ! IL-8R

[Term]
id: IMR:0000608
name: IL-10R
exact_synonym: "interleukin-10 receptor" []
xref_analog: GO:0004920
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000609
name: IL-10R1
exact_synonym: "IL-10RA" []
exact_synonym: "interleukin-10 receptor alpha" []
relationship: part_of IMR:0000608 ! IL-10R

[Term]
id: IMR:0000610
name: IL-10R2
exact_synonym: "IL-10RB" []
exact_synonym: "interleukin-10 receptor beta" []
relationship: part_of IMR:0000608 ! IL-10R

[Term]
id: IMR:0000611
name: IL-11R
xref_analog: GO:0004921
is_a: IMR:0000096 ! interleukin receptor

[Term]
id: IMR:0000612
name: IL-11RA2
exact_synonym: "interleukin-11 receptor alpha chain 2" []
exact_synonym: "interleukin-11 receptor beta chain" []
relationship: part_of IMR:0000611 ! IL-11R

[Term]
id: IMR:0000613
name: IL-11RA1
exact_synonym: "interleukin-11 receptor alpha chain 1" []
relationship: part_of IMR:0000611 ! IL-11R

[Term]
id: IMR:0000614
name: neuregulin-1
exact_synonym: "NRG-1" []
is_a: IMR:0000048 ! neuregulin

[Term]
id: IMR:0000615
name: neuregulin-2
exact_synonym: "NRG-2" []
is_a: IMR:0000048 ! neuregulin

[Term]
id: IMR:0000616
name: neuregulin-3
exact_synonym: "NRG-3" []
is_a: IMR:0000048 ! neuregulin

[Term]
id: IMR:0000617
name: neuregulin-4
exact_synonym: "NRG-4" []
is_a: IMR:0000048 ! neuregulin

[Term]
id: IMR:0000618
name: ICAM-1
exact_synonym: "intercellular adhesion molecule 1" []
is_a: IMR:0000178 ! ICAM

[Term]
id: IMR:0000619
name: ICAM-2
exact_synonym: "intercellular adhesion molecule 2" []
is_a: IMR:0000178 ! ICAM

[Term]
id: IMR:0000620
name: ICAM-3
exact_synonym: "intercellular adhesion molecule 3" []
is_a: IMR:0000178 ! ICAM

[Term]
id: IMR:0000621
name: ICAM-4
exact_synonym: "intercellular adhesion molecule 4" []
is_a: IMR:0000178 ! ICAM

[Term]
id: IMR:0000622
name: ICAM-5
exact_synonym: "intercellular adhesion molecule 5" []
is_a: IMR:0000178 ! ICAM

[Term]
id: IMR:0000623
name: Integrin alpha-1
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000624
name: Integrin alpha-2
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000625
name: Integrin alpha-3
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000626
name: Integrin alpha-4
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000627
name: Integrin alpha-5
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000628
name: Integrin alpha-6
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000629
name: Integrin alpha-7
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000630
name: Integrin alpha-8
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000631
name: Integrin alpha-9
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000632
name: Integrin alpha-10
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000633
name: Integrin alpha-11
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000634
name: Integrin alpha-IIb
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000635
name: Integrin alpha-D
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000636
name: Integrin alpha-E
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000637
name: Integrin alpha-L
is_a: IMR:0000173 ! Integrin alpha
relationship: part_of IMR:0000650 ! LFA-1

[Term]
id: IMR:0000638
name: Integrin alpha-M
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000639
name: Integrin alpha-V
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000640
name: Integrin alpha-X
is_a: IMR:0000173 ! Integrin alpha

[Term]
id: IMR:0000641
name: Integrin beta-1
is_a: IMR:0000174 ! Integrin beta

[Term]
id: IMR:0000642
name: Integrin beta-2
is_a: IMR:0000174 ! Integrin beta
relationship: part_of IMR:0000650 ! LFA-1

[Term]
id: IMR:0000643
name: Integrin beta-3
is_a: IMR:0000174 ! Integrin beta

[Term]
id: IMR:0000644
name: Integrin beta-4
is_a: IMR:0000174 ! Integrin beta

[Term]
id: IMR:0000645
name: Integrin beta-5
is_a: IMR:0000174 ! Integrin beta

[Term]
id: IMR:0000646
name: Integrin beta-6
is_a: IMR:0000174 ! Integrin beta

[Term]
id: IMR:0000647
name: Integrin beta-7
is_a: IMR:0000174 ! Integrin beta

[Term]
id: IMR:0000648
name: Integrin beta-8
is_a: IMR:0000174 ! Integrin beta

[Term]
id: IMR:0000649
name: CD44
is_a: IMR:0001125 ! heparan sulfate proteoglycan

[Term]
id: IMR:0000650
name: LFA-1
is_a: IMR:0000166 ! adhesion molecule

[Term]
id: IMR:0000651
name: 1-acylglycerol-3-phosphate
exact_synonym: "1-acyl-sn-glycerol-3-phosphate" []
xref_analog: KEGG:C00681
is_a: IMR:0100182 ! LPA

[Term]
id: IMR:0000652
name: 2-acylglycerol-3-phosphate
exact_synonym: "2-acyl-sn-glycerol-3-phosphate" []
xref_analog: KEGG:C03974
is_a: IMR:0100182 ! LPA

[Term]
id: IMR:0000653
name: nucleocytoplasmic transport protein
xref_analog: GO:0005487
is_a: IMR:0100009 ! intracellular transport protein

[Term]
id: IMR:0000654
name: vesicular transport protein
is_a: IMR:0100009 ! intracellular transport protein

[Term]
id: IMR:0000655
name: channel
def: "Forms a water-filled pore across the bilayer through which specific solute can diffuse." [ISBN:0815340729]
xref_analog: GO:0015267
is_a: IMR:0001049 ! membrane transport protein

[Term]
id: IMR:0000656
name: water channel
xref_analog: GO:0015250
is_a: IMR:0000655 ! channel

[Term]
id: IMR:0000657
name: alpha-COP
exact_synonym: "coatomer alpha subunit" []
relationship: part_of IMR:0000525 ! coatomer protein complex

[Term]
id: IMR:0000658
name: beta-COP
exact_synonym: "coatomer beta subunit" []
relationship: part_of IMR:0000525 ! coatomer protein complex

[Term]
id: IMR:0000659
name: delta-COP
exact_synonym: "coatomer delta subunit" []
relationship: part_of IMR:0000525 ! coatomer protein complex

[Term]
id: IMR:0000660
name: epsilon-COP
exact_synonym: "coatomer epsilon subunit" []
relationship: part_of IMR:0000525 ! coatomer protein complex

[Term]
id: IMR:0000661
name: gamma-COP
exact_synonym: "coatomer gamma subunit" []
relationship: part_of IMR:0000525 ! coatomer protein complex

[Term]
id: IMR:0000662
name: beta'-COP
exact_synonym: "Coatomer beta' subunit" []
relationship: part_of IMR:0000525 ! coatomer protein complex

[Term]
id: IMR:0000663
name: zeta-COP
exact_synonym: "Coatomer zeta subunit" []
relationship: part_of IMR:0000525 ! coatomer protein complex

[Term]
id: IMR:0000664
name: zeta-1 COP
exact_synonym: "Coatomer zeta-1 subunit" []
is_a: IMR:0000663 ! zeta-COP

[Term]
id: IMR:0000665
name: zeta-2 COP
exact_synonym: "Coatomer zeta-2 subunit" []
is_a: IMR:0000663 ! zeta-COP

[Term]
id: IMR:0000666
name: ezrin
is_a: IMR:0000186 ! ERM family

[Term]
id: IMR:0000667
name: moesin
is_a: IMR:0000186 ! ERM family

[Term]
id: IMR:0000668
name: radixin
is_a: IMR:0000186 ! ERM family

[Term]
id: IMR:0000669
name: PAK2
is_a: IMR:0000238 ! PAK

[Term]
id: IMR:0000670
name: PAK3
is_a: IMR:0000238 ! PAK

[Term]
id: IMR:0000671
name: PAK4
is_a: IMR:0000238 ! PAK

[Term]
id: IMR:0000672
name: PAK6
exact_synonym: "PAK5" []
is_a: IMR:0000238 ! PAK

[Term]
id: IMR:0000673
name: PAK7
exact_synonym: "PAK5" []
is_a: IMR:0000238 ! PAK

[Term]
id: IMR:0000674
name: A-Raf
is_a: IMR:0000231 ! Raf

[Term]
id: IMR:0000675
name: B-Raf
is_a: IMR:0000231 ! Raf

[Term]
id: IMR:0000676
name: type I alpha cGMP-dependent protein kinase
is_a: IMR:0000251 ! PKG

[Term]
id: IMR:0000677
name: type II cGMP-dependent protein kinase
is_a: IMR:0000251 ! PKG

[Term]
id: IMR:0000678
name: type I beta cGMP-dependent protein kinase
is_a: IMR:0000251 ! PKG

[Term]
id: IMR:0000679
name: Plk1
is_a: IMR:0000256 ! Plk

[Term]
id: IMR:0000680
name: Plk3
is_a: IMR:0000256 ! Plk

[Term]
id: IMR:0000681
name: non-receptor serine/threonine kinase
xref_analog: GO:0004702
is_a: IMR:0000223 ! protein serine/threonine kinase

[Term]
id: IMR:0000682
name: non-receptor tyrosine kinase
xref_analog: GO:0004715
xref_analog: GO:0004716
is_a: IMR:0000210 ! protein tyrosine kinase

[Term]
id: IMR:0000683
name: JNK1
exact_synonym: "p54 gamma SAPK" []
exact_synonym: "SAPK-1" []
is_a: IMR:0000225 ! JNK/SAPK

[Term]
id: IMR:0000684
name: JNK2
exact_synonym: "p54 alpha SAPK" []
is_a: IMR:0000225 ! JNK/SAPK

[Term]
id: IMR:0000685
name: JNK3
exact_synonym: "p54 beta SAPK" []
is_a: IMR:0000225 ! JNK/SAPK

[Term]
id: IMR:0000686
name: p38alpha
exact_synonym: "CRK1" []
exact_synonym: "CSBP1" []
exact_synonym: "CSBP2" []
exact_synonym: "MPK2" []
exact_synonym: "Mxi2" []
exact_synonym: "p38 MAPK" []
exact_synonym: "p38/HOG1" []
exact_synonym: "p40" []
exact_synonym: "RK" []
exact_synonym: "RK/p38" []
exact_synonym: "SAPK-2" []
exact_synonym: "SAPK2a" []
is_a: IMR:0000226 ! p38

[Term]
id: IMR:0000687
name: p38beta
exact_synonym: "p38-2" []
exact_synonym: "SAPK2b" []
is_a: IMR:0000226 ! p38

[Term]
id: IMR:0000688
name: p38gamma
exact_synonym: "ERK6" []
exact_synonym: "SAPK-3" []
is_a: IMR:0000226 ! p38

[Term]
id: IMR:0000689
name: p38delta
exact_synonym: "SAPK-4" []
is_a: IMR:0000226 ! p38

[Term]
id: IMR:0000691
name: calcitonin gene-related peptide I
exact_synonym: "CGRP-I" []
is_a: IMR:0100162 ! calcitonin gene-related peptide

[Term]
id: IMR:0000692
name: calcitonin gene-related peptide II
exact_synonym: "CGRP-II" []
is_a: IMR:0100162 ! calcitonin gene-related peptide

[Term]
id: IMR:0000693
name: neurophysin 1
is_a: IMR:0100163 ! neurophysin

[Term]
id: IMR:0000694
name: neurophysin 2
is_a: IMR:0100163 ! neurophysin

[Term]
id: IMR:0000695
name: H-Ras
alt_id: IMR:0011341
exact_synonym: "c-H-ras" []
exact_synonym: "HRAS" []
exact_synonym: "Transforming protein p21/H-Ras-1" []
is_a: IMR:0000290 ! Ras

[Term]
id: IMR:0000696
name: N-Ras
alt_id: IMR:0011343
exact_synonym: "NRAS" []
exact_synonym: "Transforming protein N-Ras" []
is_a: IMR:0000290 ! Ras

[Term]
id: IMR:0000697
name: K-Ras2A
alt_id: IMR:0011342
exact_synonym: "c-K-ras" []
exact_synonym: "K-Ras 2A" []
exact_synonym: "K-Ras4A" []
exact_synonym: "Ki-Ras" []
exact_synonym: "KRAS2" []
exact_synonym: "Transforming protein p21A" []
is_a: IMR:0000291 ! K-Ras

[Term]
id: IMR:0000698
name: K-Ras2B
exact_synonym: "K-Ras4B" []
is_a: IMR:0000291 ! K-Ras

[Term]
id: IMR:0000699
name: Cdc42
is_a: IMR:0000295 ! Rho family

[Term]
id: IMR:0000700
name: p50:RelA
is_a: IMR:0000382 ! NF-kappaB

[Term]
id: IMR:0000701
name: IKK family
exact_synonym: "I-kappaB kinase family" []
xref_analog: GO:0008384
is_a: IMR:0000681 ! non-receptor serine/threonine kinase

[Term]
id: IMR:0000702
name: BMPRII
is_a: IMR:0000094 ! TGF-beta receptor type II

[Term]
id: IMR:0000703
name: ALK-2/ActRI
is_a: IMR:0000093 ! TGF-beta receptor type I

[Term]
id: IMR:0000704
name: ALK-3/BMP-RIA
exact_synonym: "BMPRIA" []
is_a: IMR:0001425 ! BMPRI

[Term]
id: IMR:0000705
name: ALK-6/BMP-RIB
exact_synonym: "BMPRIB" []
is_a: IMR:0001425 ! BMPRI

[Term]
id: IMR:0000706
name: ALK-4/ActRIB
is_a: IMR:0000093 ! TGF-beta receptor type I

[Term]
id: IMR:0000707
name: ActRII
is_a: IMR:0000094 ! TGF-beta receptor type II

[Term]
id: IMR:0000708
name: ActRIIB
is_a: IMR:0000094 ! TGF-beta receptor type II

[Term]
id: IMR:0000709
name: ALK-7
is_a: IMR:0000093 ! TGF-beta receptor type I

[Term]
id: IMR:0000710
name: ALK-5/TbetaRI
exact_synonym: "activin receptor-like kinase-5" []
exact_synonym: "ALK-5" []
is_a: IMR:0000093 ! TGF-beta receptor type I

[Term]
id: IMR:0000711
name: ALK-1
is_a: IMR:0000093 ! TGF-beta receptor type I

[Term]
id: IMR:0000712
name: TbetaRII
is_a: IMR:0000094 ! TGF-beta receptor type II

[Term]
id: IMR:0000713
name: AMHR
is_a: IMR:0000094 ! TGF-beta receptor type II

[Term]
id: IMR:0000714
name: PLCbeta1
exact_synonym: "phospholipase C beta 1" []
is_a: IMR:0000286 ! PLCbeta

[Term]
id: IMR:0000715
name: PLCbeta2
exact_synonym: "phospholipase C beta 2" []
is_a: IMR:0000286 ! PLCbeta

[Term]
id: IMR:0000716
name: PLCbeta3
exact_synonym: "phospholipase C beta 3" []
is_a: IMR:0000286 ! PLCbeta

[Term]
id: IMR:0000717
name: PLCbeta4
exact_synonym: "phospholipase C beta 4" []
is_a: IMR:0000286 ! PLCbeta

[Term]
id: IMR:0000718
name: adenylate cyclase type I
exact_synonym: "adenylate cyclase type 1" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000719
name: adenylate cyclase type II
exact_synonym: "adenylate cyclase type 2" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000720
name: adenylate cyclase type III
exact_synonym: "adenylate cyclase type 3" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000721
name: adenylate cyclase type IV
exact_synonym: "adenylate cyclase type 4" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000722
name: adenylate cyclase type V
exact_synonym: "adenylate cyclase type 5" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000723
name: adenylate cyclase type VI
exact_synonym: "adenylate cyclase type 6" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000724
name: adenylate cyclase type VII
exact_synonym: "adenylate cyclase type 7" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000725
name: adenylate cyclase type VIII
exact_synonym: "adenylate cyclase type 8" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000726
name: adenylate cyclase type IX
exact_synonym: "adenylate cyclase type 9" []
is_a: IMR:0000313 ! adenylate cyclase

[Term]
id: IMR:0000727
name: group IB phospholipase A2
is_a: IMR:0000283 ! PLA2

[Term]
id: IMR:0000728
name: PLD1
exact_synonym: "phospholipase D1" []
is_a: IMR:0000287 ! PLD

[Term]
id: IMR:0000729
name: PLD2
exact_synonym: "phospholipase D2" []
is_a: IMR:0000287 ! PLD

[Term]
id: IMR:0000730
name: GPI-PLD1
exact_synonym: "glycosylphosphatidylinositol phospholipase D1" []
exact_synonym: "phosphatidylinositol-glycan-specific phospholipase D1" []
is_a: IMR:0001997 ! GPI-PLD

[Term]
id: IMR:0000731
name: GPI-PLD2
exact_synonym: "glycosylphosphatidylinositol phospholipase D2" []
exact_synonym: "phosphatidylinositol-glycan-specific phospholipase D2" []
is_a: IMR:0001997 ! GPI-PLD

[Term]
id: IMR:0000732
name: PLC gamma1
exact_synonym: "phospholipase C gamma 1" []
is_a: IMR:0000285 ! PLC gamma

[Term]
id: IMR:0000733
name: PLC gamma2
exact_synonym: "phospholipase C gamma 2" []
is_a: IMR:0000285 ! PLC gamma

[Term]
id: IMR:0000734
name: COX-1
exact_synonym: "prostaglandin endoperoxide synthase 2" []
is_a: IMR:0000331 ! COX

[Term]
id: IMR:0000735
name: COX-2
exact_synonym: "prostaglandin endoperoxide synthase 2" []
is_a: IMR:0000331 ! COX

[Term]
id: IMR:0000736
name: Grb10
alt_id: IMR:0010277
exact_synonym: "GRB10 adaptor protein" []
exact_synonym: "Growth factor receptor-bound protein 10" []
exact_synonym: "Insulin receptor binding protein GRB-IR" []
is_a: IMR:0100382 ! Grb7/10/14 family

[Term]
id: IMR:0000737
name: Grb14
is_a: IMR:0100382 ! Grb7/10/14 family

[Term]
id: IMR:0000738
name: ShcA
alt_id: IMR:0010596
alt_id: IMR:0011555
is_a: IMR:0000347 ! Shc

[Term]
id: IMR:0000739
name: ShcB
is_a: IMR:0000347 ! Shc

[Term]
id: IMR:0000740
name: ShcC
is_a: IMR:0000347 ! Shc

[Term]
id: IMR:0000741
name: Gads
exact_synonym: "Grb2-related adaptor downstream of Shc" []
is_a: IMR:0000339 ! Grb2 family

[Term]
id: IMR:0000742
name: DD-containing adaptor protein
exact_synonym: "death domain-containing adaptor protein" []
is_a: IMR:0000743 ! adaptor protein

[Term]
id: IMR:0000743
name: adaptor protein
is_a: IMR:0000333 ! adaptor/docking/scaffold/anchoring protein

[Term]
id: IMR:0000744
name: anchoring protein
is_a: IMR:0000333 ! adaptor/docking/scaffold/anchoring protein

[Term]
id: IMR:0000745
name: Crk family
def: "Alternative splicing of the mammal crk gene yields two translation products designated the 28-kDa Crk-I and the 42-kDa Crk-II protein. The Crk-II protein contains an amino-terminal SH2 domain followed by two SH3 domains. The Crk-I protein does not contain the second SH3 domain. The 36-kDa Crk-L protein is similar to CrkII, but is encoded by a separate gene." [PubMed:10393272]
is_a: IMR:0000334 ! SH2/SH3 adaptor protein

[Term]
id: IMR:0000746
name: intracellular ligand-gated ion channel
xref_analog: GO:0005217
is_a: IMR:0000082 ! ligand-gated ion channel
is_a: IMR:0001013 ! intracellular ligand receptor

[Term]
id: IMR:0000747
name: extracellular ligand-gated ion channel
xref_analog: GO:0005230
is_a: IMR:0000082 ! ligand-gated ion channel
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000748
name: voltage-gated calcium channel
exact_synonym: "voltage-dependent calcium channel" []
xref_analog: GO:0005245
is_a: IMR:0000499 ! calcium channel
is_a: IMR:0100584 ! voltage-gated ion channel

[Term]
id: IMR:0000749
name: L-type Ca2+ channel
def: "L for long-lasting. Wide distribution, well characterized in heart, smooth and skeltal muscle and some neurones. Highly sensitive to the dihydropyridines, phenylalkylamines and the  benzothiazepines. Consists of five subunits, known as alpha1, alpha2, beta, gamma and delta. The delta subunit is linked by disulphide bonds to the alpha2 subunit." [ISBN:0121844536]
exact_synonym: "voltage-dependent L-type calcium channel" []
exact_synonym: "voltage-gated L-type calcium channel" []
is_a: IMR:0000748 ! voltage-gated calcium channel

[Term]
id: IMR:0000750
name: voltage-gated calcium channel alpha-1C subunit
is_a: IMR:0000751 ! L-type Ca2+ channel alpha-1 subunit

[Term]
id: IMR:0000751
name: L-type Ca2+ channel alpha-1 subunit
def: "The alpha-1 subunit contains the pore of the channel and is the main site of action of the L-type-specific Ca2+ channel agonists and antagonists." [ISBN:0121844536]
relationship: part_of IMR:0000749 ! L-type Ca2+ channel

[Term]
id: IMR:0000752
name: voltage-gated calcium channel alpha-1D subunit
is_a: IMR:0000751 ! L-type Ca2+ channel alpha-1 subunit

[Term]
id: IMR:0000753
name: voltage-gated calcium channel alpha-1F subunit
is_a: IMR:0000751 ! L-type Ca2+ channel alpha-1 subunit

[Term]
id: IMR:0000754
name: voltage-gated calcium channel alpha-1S subunit
is_a: IMR:0000751 ! L-type Ca2+ channel alpha-1 subunit

[Term]
id: IMR:0000755
name: voltage-gated calcium channel beta subunit
relationship: part_of IMR:0000749 ! L-type Ca2+ channel
relationship: part_of IMR:0000772 ! N-type Ca2+ channel

[Term]
id: IMR:0000756
name: voltage-gated calcium channel beta-1 subunit
is_a: IMR:0000755 ! voltage-gated calcium channel beta subunit

[Term]
id: IMR:0000757
name: voltage-gated calcium channel beta-2 subunit
is_a: IMR:0000755 ! voltage-gated calcium channel beta subunit

[Term]
id: IMR:0000758
name: voltage-gated calcium channel beta-3 subunit
is_a: IMR:0000755 ! voltage-gated calcium channel beta subunit

[Term]
id: IMR:0000759
name: voltage-gated calcium channel beta-4 subunit
is_a: IMR:0000755 ! voltage-gated calcium channel beta subunit

[Term]
id: IMR:0000760
name: voltage-gated calcium channel alpha-2/delta subunit
relationship: part_of IMR:0000749 ! L-type Ca2+ channel
relationship: part_of IMR:0000772 ! N-type Ca2+ channel

[Term]
id: IMR:0000761
name: voltage-gated calcium channel alpha-1B subunit
relationship: part_of IMR:0000772 ! N-type Ca2+ channel

[Term]
id: IMR:0000762
name: voltage-gated calcium channel gamma subunit
relationship: part_of IMR:0000749 ! L-type Ca2+ channel

[Term]
id: IMR:0000763
name: voltage-gated calcium channel gamma-1 subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000764
name: voltage-gated calcium channel gamma-2 subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000765
name: voltage-gated calcium channel gamma-3 subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000766
name: voltage-gated calcium channel gamma-4 subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000767
name: voltage-gated calcium channel gamma-5 subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000768
name: voltage-gated calcium channel gamma-6 subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000769
name: voltage-gated calcium channel gamma-7 subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000770
name: voltage-gated calcium channel gamma-8 subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000771
name: voltage-gated calcium channel gamma-like subunit
is_a: IMR:0000762 ! voltage-gated calcium channel gamma subunit

[Term]
id: IMR:0000772
name: N-type Ca2+ channel
def: "N for neuronal, neither L nor T. Found specifically in neurones. Blocked by omega-conotoxin GVIA (omega-CTx-GVIA). Consists of alpha1, alpha2-delta and beta subunits. " [ISBN:0121844536]
exact_synonym: "voltage-dependent N-type calcium channel" []
exact_synonym: "voltage-gated N-type calcium channel" []
is_a: IMR:0000748 ! voltage-gated calcium channel

[Term]
id: IMR:0000773
name: T-type Ca2+ channel
def: "T for transient. Low voltage activated transient current. Rapid voltage-dependent inactivation. Concentrated in conducting system of heart (sinoatrial node, atrioventricular node), smooth muscle, endocrine cells and some neurones. In the mature mammalian brain, they are prominent in thalamic and hypothalamic neurones." [ISBN:0121844536]
is_a: IMR:0000748 ! voltage-gated calcium channel

[Term]
id: IMR:0000774
name: ryanodine receptor
exact_synonym: "RyR" []
is_a: IMR:0000499 ! calcium channel
is_a: IMR:0000746 ! intracellular ligand-gated ion channel

[Term]
id: IMR:0000775
name: store-operated calcium channel
is_a: IMR:0000499 ! calcium channel

[Term]
id: IMR:0000776
name: P/Q-type Ca2+ channel
is_a: IMR:0000748 ! voltage-gated calcium channel

[Term]
id: IMR:0000777
name: voltage-gated sodium channel
is_a: IMR:0000497 ! sodium channel
is_a: IMR:0100584 ! voltage-gated ion channel

[Term]
id: IMR:0000778
name: voltage-gated calcium channel alpha-1A subunit
relationship: part_of IMR:0000776 ! P/Q-type Ca2+ channel

[Term]
id: IMR:0000779
name: T-type Ca2+ channel alpha-1 subunit
relationship: part_of IMR:0000773 ! T-type Ca2+ channel

[Term]
id: IMR:0000780
name: voltage-gated calcium channel alpha-1G subunit
is_a: IMR:0000779 ! T-type Ca2+ channel alpha-1 subunit

[Term]
id: IMR:0000781
name: voltage-gated calcium channel alpha-1H subunit
is_a: IMR:0000779 ! T-type Ca2+ channel alpha-1 subunit

[Term]
id: IMR:0000782
name: voltage-gated calcium channel alpha-1I subunit
is_a: IMR:0000779 ! T-type Ca2+ channel alpha-1 subunit

[Term]
id: IMR:0000783
name: R-type Ca2+ channel
is_a: IMR:0000748 ! voltage-gated calcium channel

[Term]
id: IMR:0000784
name: voltage-gated calcium channel alpha-1E subunit
relationship: part_of IMR:0000783 ! R-type Ca2+ channel

[Term]
id: IMR:0000785
name: amiloride-sensitive sodium channel
exact_synonym: "ENaC" []
exact_synonym: "epithelial sodium channel" []
is_a: IMR:0000497 ! sodium channel
is_a: IMR:0000746 ! intracellular ligand-gated ion channel

[Term]
id: IMR:0000786
name: voltage-gated sodium channel alpha subunit
relationship: part_of IMR:0000777 ! voltage-gated sodium channel

[Term]
id: IMR:0000787
name: voltage-gated sodium channel beta subunit
relationship: part_of IMR:0000777 ! voltage-gated sodium channel

[Term]
id: IMR:0000788
name: Nav1.1
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000789
name: Nav1.2
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000790
name: Nav1.3
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000791
name: Nav1.4
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000792
name: Nav1.5
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000793
name: Nav1.6
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000794
name: Nav1.7
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000795
name: Nav1.8
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000796
name: Nav1.9
exact_synonym: "NaN" []
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000797
name: Nax
is_a: IMR:0000786 ! voltage-gated sodium channel alpha subunit

[Term]
id: IMR:0000798
name: voltage-gated sodium channel beta-1 subunit
is_a: IMR:0000787 ! voltage-gated sodium channel beta subunit

[Term]
id: IMR:0000799
name: voltage-gated sodium channel beta-2 subunit
is_a: IMR:0000787 ! voltage-gated sodium channel beta subunit

[Term]
id: IMR:0000800
name: voltage-gated sodium channel beta-3 subunit
is_a: IMR:0000787 ! voltage-gated sodium channel beta subunit

[Term]
id: IMR:0000801
name: amiloride-sensitive sodium channel alpha subunit
exact_synonym: "ENaC alpha subunit" []
exact_synonym: "epithelial sodium channel alpha subunit" []
relationship: part_of IMR:0000785 ! amiloride-sensitive sodium channel

[Term]
id: IMR:0000802
name: amiloride-sensitive sodium channel beta subunit
exact_synonym: "ENaC beta subunit" []
exact_synonym: "epithelial sodium channel beta subunit" []
relationship: part_of IMR:0000785 ! amiloride-sensitive sodium channel

[Term]
id: IMR:0000803
name: amiloride-sensitive sodium channel gamma subunit
exact_synonym: "ENaC gamma subunit" []
exact_synonym: "epithelial sodium channel gamma subunit" []
relationship: part_of IMR:0000785 ! amiloride-sensitive sodium channel

[Term]
id: IMR:0000804
name: amiloride-sensitive sodium channel delta subunit
exact_synonym: "ENaC delta subunit" []
exact_synonym: "epithelial sodium channel delta subunit" []
relationship: part_of IMR:0000785 ! amiloride-sensitive sodium channel

[Term]
id: IMR:0000805
name: GADD45 alpha
is_a: IMR:0000559 ! GADD45

[Term]
id: IMR:0000806
name: GADD45 beta
exact_synonym: "MyD118" []
is_a: IMR:0000559 ! GADD45

[Term]
id: IMR:0000807
name: GADD45 gamma
exact_synonym: "CR6" []
is_a: IMR:0000559 ! GADD45

[Term]
id: IMR:0000808
name: disabled-1
is_a: IMR:0000558 ! disabled

[Term]
id: IMR:0000809
name: disabled-2
exact_synonym: "DOC-2" []
is_a: IMR:0000558 ! disabled

[Term]
id: IMR:0000810
name: DAB_DROME
exact_synonym: "cDNA C" [FlyBase:FBgn0000414]
exact_synonym: "CG9695" [FlyBase:FBgn0000414]
exact_synonym: "Dab" [UniProt:P98081, FlyBase:FBgn0000414]
exact_synonym: "dab" [FlyBase:FBgn0000414]
exact_synonym: "disabled" [FlyBase:FBgn0000414]
exact_synonym: "Disabled" [FlyBase:FBgn0000414]
exact_synonym: "Protein disabled" [UniProt:P98081]
xref_analog: UniProt:P98081
relationship: sequence_of IMR:0000558 ! disabled

[Term]
id: IMR:0000811
name: CD80
def: "B7.1 (CD80) and B7.2 (CD86) - the two structurally homologous ligands of CD28 - are expressed by professional antigen-presenting cells (APCs), such as dendritic cells (DCs), macrophages and activated B cells, belong to the immunoglobulin superfamily and might exist as dimers and monomers, respectively." [PubMed:14647476]
exact_synonym: "B7.1" []
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000812
name: CD86
def: "B7.1 (CD80) and B7.2 (CD86) - the two structurally homologous ligands of CD28 - are expressed by professional antigen-presenting cells (APCs), such as dendritic cells (DCs), macrophages and activated B cells, belong to the immunoglobulin superfamily and might exist as dimers and monomers, respectively." [PubMed:14647476]
exact_synonym: "B7.2" []
is_a: IMR:0001012 ! extracellular ligand receptor

[Term]
id: IMR:0000813
name: c-FOS
is_a: IMR:0000415 ! FOS

[Term]
id: IMR:0000814
name: FOSB
is_a: IMR:0000415 ! FOS

[Term]
id: IMR:0000815
name: FRA-1
is_a: IMR:0000415 ! FOS

[Term]
id: IMR:0000816
name: FRA-2
is_a: IMR:0000415 ! FOS

[Term]
id: IMR:0000817
name: c-JUN
exact_synonym: "AP-1" []
is_a: IMR:0000416 ! JUN

[Term]
id: IMR:0000818
name: JUNB
is_a: IMR:0000416 ! JUN

[Term]
id: IMR:0000819
name: JUND
is_a: IMR:0000416 ! JUN

[Term]
id: IMR:0000820
name: c-Maf
is_a: IMR:0000411 ! Maf

[Term]
id: IMR:0000821
name: MafF
is_a: IMR:0000411 ! Maf

[Term]
id: IMR:0000822
name: MafG
is_a: IMR:0000411 ! Maf

[Term]
id: IMR:0000823
name: MafK
is_a: IMR:0000411 ! Maf

[Term]
id: IMR:0000824
name: MafB
is_a: IMR:0000411 ! Maf

[Term]
id: IMR:0000825
name: ATF
exact_synonym: "activating transcription factor" []
is_a: IMR:0000369 ! transcriptional regulator
relationship: part_of IMR:0000414 ! AP-1

[Term]
id: IMR:0000826
name: ATF-1
exact_synonym: "activating transcription factor 1" []
is_a: IMR:0000825 ! ATF

[Term]
id: IMR:0000827
name: ATF-2
exact_synonym: "activating transcription factor 2" []
is_a: IMR:0000825 ! ATF

[Term]
id: IMR:0000828
name: ATF-3
exact_synonym: "activating transcription factor 3" []
is_a: IMR:0000825 ! ATF

[Term]
id: IMR:0000829
name: ATF-4
exact_synonym: "activating transcription factor 4" []
is_a: IMR:0000825 ! ATF

[Term]
id: IMR:0000830
name: ATF-5
exact_synonym: "activating transcription factor 5" []
is_a: IMR:0000825 ! ATF

[Term]
id: IMR:0000831
name: ATF-6 alpha
exact_synonym: "activating transcription factor 6 alpha" []
is_a: IMR:0000825 ! ATF

[Term]
id: IMR:0000832
name: ATF-6 beta
exact_synonym: "activating transcription factor 6 beta" []
is_a: IMR:0000825 ! ATF

[Term]
id: IMR:0000833
name: ATF-7
exact_synonym: "activating transcription factor 7" []
exact_synonym: "ATF-a" []
is_a: IMR:0000825 ! ATF

[Term]
id: IMR:0000834
name: C/EBP alpha
exact_synonym: "CCAAT/enhancer binding protein alpha" []
is_a: IMR:0000422 ! C/EBP

[Term]
id: IMR:0000835
name: C/EBP beta
exact_synonym: "CCAAT/enhancer binding protein beta" []
is_a: IMR:0000422 ! C/EBP

[Term]
id: IMR:0000836
name: C/EBP delta
exact_synonym: "CCAAT/enhancer binding protein delta" []
is_a: IMR:0000422 ! C/EBP

[Term]
id: IMR:0000837
name: C/EBP gamma
exact_synonym: "CCAAT/enhancer binding protein gamma" []
is_a: IMR:0000422 ! C/EBP

[Term]
id: IMR:0000838
name: C/EBP epsilon
exact_synonym: "CCAAT/enhancer binding protein epsilon" []
is_a: IMR:0000422 ! C/EBP

[Term]
id: IMR:0000839
name: E2F-1
alt_id: IMR:0010715
exact_synonym: "E2F-1" []
exact_synonym: "E2F1" []
exact_synonym: "PBR3" []
exact_synonym: "PRB-binding protein E2F-1" []
exact_synonym: "RBAP-1" []
exact_synonym: "RBBP-3" []
exact_synonym: "Retinoblastoma binding protein 3" []
exact_synonym: "Retinoblastoma-associated protein 1" []
exact_synonym: "Transcription factor E2F1" []
is_a: IMR:0000848 ! E2F

[Term]
id: IMR:0000840
name: E2F-2
alt_id: IMR:0010717
exact_synonym: "E2F2" []
exact_synonym: "Transcription factor E2F2" []
is_a: IMR:0000848 ! E2F

[Term]
id: IMR:0000841
name: E2F-3
alt_id: IMR:0010232
exact_synonym: "E2F3" []
exact_synonym: "Transcription factor E2F3" []
is_a: IMR:0000848 ! E2F

[Term]
id: IMR:0000842
name: E2F-4
alt_id: IMR:0010720
exact_synonym: "E2F4" []
exact_synonym: "Transcription factor E2F4" []
exact_synonym: "Transcription factor E2F4 (E2F-4)" []
is_a: IMR:0000848 ! E2F

[Term]
id: IMR:0000843
name: E2F-5
alt_id: IMR:0010721
exact_synonym: "E2F5" []
exact_synonym: "Transcription factor E2F5" []
exact_synonym: "Transcription factor E2F5 (E2F-5)" []
is_a: IMR:0000848 ! E2F

[Term]
id: IMR:0000844
name: E2F-6
is_a: IMR:0000848 ! E2F

[Term]
id: IMR:0000845
name: DP-1
alt_id: IMR:0010718
exact_synonym: "DP-1" []
exact_synonym: "DRTF1" []
exact_synonym: "DRTF1- polypeptide-1" []
exact_synonym: "E2F dimerization partner 1" []
exact_synonym: "Transcription factor Dp-1" []
exact_synonym: "Transcription factor DP-1 (E2F dimerization partner 1)(DRTF1-polypeptide-1) (DRTF1)" []
is_a: IMR:0000847 ! DP

[Term]
id: IMR:0000846
name: DP-2
is_a: IMR:0000847 ! DP

[Term]
id: IMR:0000847
name: DP
exact_synonym: "DRTF1 protein" []
xref_analog: IPR:003316
relationship: part_of IMR:0000396 ! DRTF1/E2F

[Term]
id: IMR:0000848
name: E2F
xref_analog: IPR:003316
relationship: part_of IMR:0000396 ! DRTF1/E2F

[Term]
id: IMR:0000849
name: GATA-1
is_a: IMR:0000410 ! GATA

[Term]
id: IMR:0000850
name: GATA-2
is_a: IMR:0000410 ! GATA

[Term]
id: IMR:0000851
name: GATA-3
is_a: IMR:0000410 ! GATA

[Term]
id: IMR:0000852
name: GATA-4
is_a: IMR:0000410 ! GATA

[Term]
id: IMR:0000853
name: GATA-5
is_a: IMR:0000410 ! GATA

[Term]
id: IMR:0000854
name: GATA-6
is_a: IMR:0000410 ! GATA

[Term]
id: IMR:0000855
name: NF-ATc1
is_a: IMR:0000421 ! NF-AT

[Term]
id: IMR:0000856
name: NF-ATc2
is_a: IMR:0000421 ! NF-AT

[Term]
id: IMR:0000857
name: NF-ATc3
is_a: IMR:0000421 ! NF-AT

[Term]
id: IMR:0000858
name: NF-ATc4
is_a: IMR:0000421 ! NF-AT

[Term]
id: IMR:0000859
name: 14-3-3 beta
alt_id: IMR:0010101
exact_synonym: "14-3-3 protein beta/alpha" []
exact_synonym: "KCIP-1" []
exact_synonym: "Protein 1054" []
exact_synonym: "Protein kinase C inhibitor protein-1" []
is_a: IMR:0000456 ! 14-3-3

[Term]
id: IMR:0000860
name: 14-3-3 gamma
is_a: IMR:0000456 ! 14-3-3

[Term]
id: IMR:0000861
name: 14-3-3 epsilon
is_a: IMR:0000456 ! 14-3-3

[Term]
id: IMR:0000862
name: 14-3-3 eta
is_a: IMR:0000456 ! 14-3-3

[Term]
id: IMR:0000863
name: 14-3-3 sigma
is_a: IMR:0000456 ! 14-3-3

[Term]
id: IMR:0000864
name: 14-3-3 tau/theta
is_a: IMR:0000456 ! 14-3-3

[Term]
id: IMR:0000865
name: 14-3-3 zeta
is_a: IMR:0000456 ! 14-3-3

[Term]
id: IMR:0000866
name: A-Myb
is_a: IMR:0000868 ! Myb family

[Term]
id: IMR:0000867
name: B-Myb
is_a: IMR:0000868 ! Myb family

[Term]
id: IMR:0000868
name: Myb family
is_a: IMR:0000369 ! transcriptional regulator

[Term]
id: IMR:0000869
name: NF1-A
alt_id: IMR:0010365
exact_synonym: "CCAAT-box binding transcription factor" []
exact_synonym: "CTF" []
exact_synonym: "NF-I/A" []
exact_synonym: "NF1-A" []
exact_synonym: "NFI-A" []
exact_synonym: "Nuclear factor 1 A-type" []
exact_synonym: "Nuclear factor 1/A" []
exact_synonym: "TGGCA-binding protein" []
is_a: IMR:0000409 ! NF1

[Term]
id: IMR:0000870
name: NF1-B
alt_id: IMR:0010366
exact_synonym: "CCAAT-box binding transcription factor" []
exact_synonym: "CTF" []
exact_synonym: "NF-I/B" []
exact_synonym: "NF1-B" []
exact_synonym: "NFI-B" []
exact_synonym: "Nuclear factor 1 B-type" []
exact_synonym: "Nuclear factor 1/B" []
exact_synonym: "TGGCA-binding protein" []
is_a: IMR:0000409 ! NF1

[Term]
id: IMR:0000871
name: NF1-C
alt_id: IMR:0010367
exact_synonym: "CCAAT-box binding transcription factor" []
exact_synonym: "CTF" []
exact_synonym: "NF-I/C" []
exact_synonym: "NF1-C" []
exact_synonym: "NFI-C" []
exact_synonym: "Nuclear factor 1 C-type" []
exact_synonym: "Nuclear factor 1/C" []
exact_synonym: "TGGCA-binding protein" []
is_a: IMR:0000409 ! NF1

[Term]
id: IMR:0000872
name: NF1-X
alt_id: IMR:0010368
exact_synonym: "CCAAT-box binding transcription factor" []
exact_synonym: "CTF" []
exact_synonym: "NF-I/X" []
exact_synonym: "NF1-X" []
exact_synonym: "NFI-X" []
exact_synonym: "Nuclear factor 1 X-type" []
exact_synonym: "Nuclear factor 1/X" []
exact_synonym: "TGGCA-binding protein" []
is_a: IMR:0000409 ! NF1

[Term]
id: IMR:0000873
name: p52
exact_synonym: "NF-kappaB2" []
exact_synonym: "NFKB2" []
exact_synonym: "p100" []
is_a: IMR:0000382 ! NF-kappaB

[Term]
id: IMR:0000874
name: lipid second messenger
comment: This term was made obsolete. To update annotations, consider the term 'IMR0100022:second messenger'.
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0000875
name: sphingolipid products second messenger
comment: This term was made obsolete. To update annotations, consider the term 'IMR0100022:second messenger'.
is_a: IMR:0001199 ! obsolete

[Term]
id: IMR:0000877
name: fat-soluble vitamin
xref_analog: CHEBI:24020
is_a: IMR:0001656 ! vitamin

[Term]
id: IMR:0000879
name: general transcription factor
exact_synonym: "basal transcription factor" []
exact_synonym: "basic transcription factor" []
is_a: IMR:0000368 ! transcription factor

[Term]
id: IMR:0000880
name: RNA polymerase I
exact_synonym: "pol I" []
is_a: IMR:0010028 ! RNA polymerase

[Term]
id: IMR:0000881
name: RNA polymerase II
exact_synonym: "pol II" []
is_a: IMR:0010028 ! RNA polymerase

[Term]
id: IMR:0000882
name: RNA polymerase III
exact_synonym: "pol III" []
is_a: IMR:0010028 ! RNA polymerase

[Term]
id: IMR:0000883
name: TFIIA
is_a: IMR:0000888 ! pol II general transcription factor

[Term]
id: IMR:0000884
name: TFIID
is_a: IMR:0000888 ! pol II general transcription factor

[Term]
id: IMR:0000885
name: TFIIE
is_a: IMR:0000888 ! pol II general transcription factor

[Term]
id: IMR:0000886
name: TFIIF
is_a: IMR:0000888 ! pol II general transcription factor

[Term]
id: IMR:0000887
name: TFIIH
is_a: IMR:0000888 ! pol II general transcription factor

[Term]
id: IMR:0000888
name: pol II general transcription factor
exact_synonym: "general RNA polymerase II transcription factor" []
exact_synonym: "TFII" []
exact_synonym: "transcription factor for RNA polymerase II" []
is_a: IMR:0000879 ! general transcription factor

[Term]
id: IMR:0000889
name: transcription elongation factor
exact_synonym: "transcriptional elongation factor" []
xref_analog: GO:0003711
is_a: IMR:0000368 ! transcription factor

[Term]
id: IMR:0000890
name: IRAK-1
exact_synonym: "IL-1 receptor-associated kinase 1" []
exact_synonym: "Interleukin-1 receptor-associated kinase 1" []
is_a: IMR:0100488 ! IRAK

[Term]
id: IMR:0000891
name: IRAK-2
exact_synonym: "IL-1 receptor-associated kinase 2" []
exact_synonym: "In