format-version: 1.0
date: 03:03:2011 12:59
saved-by: sakainoriko2
auto-generated-by: OBO-Edit 1.002
default-namespace: event
remark: version: 1.62

[Term]
id: IEV:0000000
name: Event

[Term]
id: IEV:0000001
name: Pathway
is_a: IEV:0000071 ! Molecular event

[Term]
id: IEV:0000002
name: Cell differentiation
def: "The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GO:0030154]
xref_analog: GO:0030154
is_a: IEV:0000069 ! Cellular event
is_a: IEV:0000083 ! Development

[Term]
id: IEV:0000003
name: Biological event
is_a: IEV:0000000 ! Event

[Term]
id: IEV:0000004
name: Binding
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000005
name: Phosphorylation
def: "Reversible reaction that can affect D,C,H,S,T,Y,R residues." [MI:0217]
xref_analog: EC:2.7.-.-
xref_analog: GO:0016310
xref_analog: MI:0217
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0000006
name: Dissociation
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000007
name: Inactivation
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000008
name: Activation
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000009
name: Translocation
def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells." [GO:0006810]
exact_synonym: "transport" []
xref_analog: GO:0006810
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000010
name: Proteasome degradation
def: "Cleavage of peptide bonds with very broad specificity." [EC:3.4.25.1]
xref_analog: EC:3.4.25.1
is_a: IEV:0003710 ! Degradation

[Term]
id: IEV:0000011
name: Dephosphorylation
def: "Phosphoresidues are cleaved and return D,C,H,S,T,Y or R residues." [MI:0203]
xref_analog: MI:0203
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0000012
name: Ubiquitination
def: "Reversible reaction that create a covalent bond between a C-terminus G of ubiquitin and a K residue of the target." [MI:0220]
xref_analog: EC:6.3.2.19
xref_analog: MI:0220
is_a: IEV:0000912 ! Ligation

[Term]
id: IEV:0000013
name: Binding in cytosol
is_a: IEV:0001730 ! Binding in cytosol and/or nucleus

[Term]
id: IEV:0000014
name: Binding in plasma membrane
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0000015
name: Binding in nucleus
is_a: IEV:0001730 ! Binding in cytosol and/or nucleus

[Term]
id: IEV:0000016
name: Binding in extracellular
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0000017
name: Binding in nuclear membrane
is_a: IEV:0000015 ! Binding in nucleus

[Term]
id: IEV:0000018
name: Nuclear import
def: "The directed movement of substances into the nucleus." [GO:0051170]
exact_synonym: "import into nucleus" []
exact_synonym: "nucleus import" []
exact_synonym: "substance nuclear import" []
xref_analog: GO:0051170
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000019
name: Nuclear export
def: "The directed movement of substances out of the nucleus." [GO:0051168]
exact_synonym: "export from nucleus" []
exact_synonym: "nucleus export" []
exact_synonym: "substance nuclear export" []
xref_analog: GO:0051168
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000020
name: Activation in cytosol
is_a: IEV:0000008 ! Activation

[Term]
id: IEV:0000021
name: Proteasome degradation in cytosol
is_a: IEV:0000010 ! Proteasome degradation

[Term]
id: IEV:0000022
name: Dephosphorylation in cytosol
is_a: IEV:0001729 ! Dephosphorylation in cytosol and/or nucleus

[Term]
id: IEV:0000023
name: Dissociation in cytosol
is_a: IEV:0000006 ! Dissociation

[Term]
id: IEV:0000024
name: Inactivation in cytosol
is_a: IEV:0000007 ! Inactivation

[Term]
id: IEV:0000025
name: Phosphorylation in cytosol
is_a: IEV:0001735 ! Phosphorylation in cytosol and/or nucleus

[Term]
id: IEV:0000026
name: Ubiquitination in cytosol
is_a: IEV:0000012 ! Ubiquitination

[Term]
id: IEV:0000027
name: Wnt signaling pathway
def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell." [GO:0016055]
exact_synonym: "Wnt receptor signaling pathway" [GO:0016055]
narrow_synonym: "Wnt signaling pathway (C. elegans)" []
narrow_synonym: "Wnt signaling pathway (Drosophila)" []
narrow_synonym: "Wnt signaling pathway (Mammalia)" []
narrow_synonym: "Wnt signaling pathway (Xenopus)" []
xref_analog: GO:0016055
xref_analog: KEGG:hsa04310
xref_analog: PubMed:15473860
is_a: IEV:0001842 ! Signaling pathway
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000091 ! Cell growth
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0002536 ! Mesodermal cell fate determination
relationship: part_of IEV:0002541 ! Endodermal cell fate determination

[Term]
id: IEV:0000028
name: Chemical treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0000029
name: Binding of Frizzled and DSH in cytosol
xref_analog: IMR:0000055
xref_analog: IMR:0100755
xref_analog: PubMed:14636582
xref_analog: PubMed:15473860
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0000030
name: Phosphorylation of DSH by CK1 in cytosol
xref_analog: IMR:0100755
xref_analog: IMR:0100809
xref_analog: PubMed:10517632
xref_analog: PubMed:10656974
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0000031
name: Inactivation of GSK3beta by DSH_p in cytosol
xref_analog: IMR:0100737
xref_analog: IMR:0100755
is_a: IEV:0000024 ! Inactivation in cytosol
is_a: IEV:0001744 ! GSK3beta inactivation signaling
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0000032
name: Complex formation of Axin, APC, GSK3beta, CK1alpha and beta catenin in cytosol
xref_analog: IMR:0000177
xref_analog: IMR:0000205
xref_analog: IMR:0000432
xref_analog: IMR:0100737
xref_analog: IMR:0100810
xref_analog: PubMed:15549094
is_a: IEV:0001968 ! Complex formation of Axin, APC, GSK-3, CK1alpha and beta catenin in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0000033
name: Binding in mitochondria membrane
is_a: IEV:0001036 ! Binding in mitochondria

[Term]
id: IEV:0000034
name: Nuclear import of beta catenin
xref_analog: IMR:0000177
xref_analog: PubMed:15473860
xref_analog: PubMed:15549094
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0000035
name: Binding of beta-catenin and TCF in inner space of nucleus
xref_analog: IMR:0000177
xref_analog: IMR:0000418
xref_analog: PubMed:12210516
xref_analog: PubMed:15473860
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001819 ! Complex formation of beta catenin, TCF/LEF, Legless, Pygopus, etc. in inner space of nucleus
relationship: part_of IEV:0003455 ! Endoderm induction Wnt signaling pathway

[Term]
id: IEV:0000036
name: Binding of TCF/LEF and responsive element in inner space of nucleus
xref_analog: IGS:0000028
xref_analog: IMR:0000418
xref_analog: PubMed:14755243
xref_analog: PubMed:15292219
xref_analog: PubMed:15473860
xref_analog: PubMed:15549094
is_a: IEV:0002098 ! Binding of transcription factor and responsive element in inner space of nucleus
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0000038
name: Activation in unidentified cellular location
is_a: IEV:0000008 ! Activation

[Term]
id: IEV:0000039
name: Proteasome degradation in unidentified cellular location
is_a: IEV:0000010 ! Proteasome degradation

[Term]
id: IEV:0000040
name: Dephosphorylation in unidentified cellular location
is_a: IEV:0000011 ! Dephosphorylation

[Term]
id: IEV:0000041
name: Dissociation of Axin, APC, GSK3beta, CK1alpha and beta-catenin in cytosol
xref_analog: IMR:0000177
xref_analog: IMR:0000205
xref_analog: IMR:0000432
xref_analog: IMR:0100737
xref_analog: IMR:0100810
xref_analog: PubMed:15473860
xref_analog: PubMed:15549094
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0000042
name: Binding of Wnt and Frizzled in extracellular
xref_analog: IMR:0000003
xref_analog: IMR:0000055
xref_analog: PubMed:15473860
xref_analog: PubMed:15549094
xref_analog: PubMed:9288750
is_a: IEV:0001816 ! Binding of Wnt and Wnt receptor in extracellular
relationship: part_of IEV:0003455 ! Endoderm induction Wnt signaling pathway

[Term]
id: IEV:0000043
name: Inorganic chemical treatment
is_a: IEV:0000028 ! Chemical treatment

[Term]
id: IEV:0000044
name: JAK STAT pathway
alt_id: IEV:0000137
def: "The processes by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes." [GO:0007259]
xref_analog: GO:0007259
xref_analog: KEGG:hsa04630
is_a: IEV:0001842 ! Signaling pathway
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000077 ! Cell cycle
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000099 ! Tumorigenesis
relationship: part_of IEV:0000448 ! Hematopoiesis

[Term]
id: IEV:0000045
name: Binding of cytokine and cytokine receptors and conformational change of receptors in plasma membrane
xref_analog: IMR:0000006
xref_analog: IMR:0000095
xref_analog: PubMed:9974393
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000046
name: Binding of cytokine receptor and STAT in cytosol
xref_analog: IMR:0000095
xref_analog: IMR:0000374
xref_analog: PubMed:15541651
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000047
name: Dimerization of STAT in cytosol
def: "The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GO:0007261]
exact_synonym: "JAK-induced STAT protein dimerization" []
exact_synonym: "STAT dimerization" []
xref_analog: GO:0007261
xref_analog: IMR:0000374
xref_analog: PubMed:12039028
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000048
name: Nuclear import of STAT dimer
def: "The transport of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GO:0007262]
exact_synonym: "STAT protein nuclear translocation" []
xref_analog: GO:0007262
xref_analog: IMR:0000374
xref_analog: PubMed:12039028
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000049
name: Binding of STAT dimer and responsive element in inner space of nucleus
xref_analog: IGS:0000028
xref_analog: IMR:0000374
xref_analog: PubMed:12039028
is_a: IEV:0002098 ! Binding of transcription factor and responsive element in inner space of nucleus
relationship: part_of IEV:0000044 ! JAK STAT pathway
relationship: part_of IEV:0002102 ! Gene expression by STAT dimer

[Term]
id: IEV:0000050
name: Transcription by STAT dimer in nucleus
xref_analog: IMR:0000374
xref_analog: PubMed:12039028
xref_analog: PubMed:14607831
is_a: IEV:0003549 ! Transcription in nucleus
relationship: part_of IEV:0002102 ! Gene expression by STAT dimer

[Term]
id: IEV:0000051
name: Binding of cytokine receptor and JAK in cytosol
xref_analog: IMR:0000095
xref_analog: IMR:0000213
xref_analog: PubMed:12039028
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000052
name: Autophosphorylation of Jak in cytosol
def: "The process of introducing a phosphoric group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GO:0042976]
exact_synonym: "activation of JAK protein" []
exact_synonym: "positive regulation of JAK protein activity by tyrosine phosphorylation" []
xref_analog: GO:0042976
xref_analog: IMR:0000213
xref_analog: PubMed:9974393
is_a: IEV:0000481 ! Autophosphorylation in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000053
name: Phosphorylation of cytokine receptor by Jak in cytosol
xref_analog: IMR:0000095
xref_analog: IMR:0000213
xref_analog: PubMed:15541651
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000054
name: Bad inactivation signaling
exact_synonym: "Bad inactivation signaling" []
exact_synonym: "Bad phosphorylation signaling" []
is_a: IEV:0001030 ! Apoptotic factor inactivation signaling
is_a: IEV:0001800 ! Negative regulation of Bad activation signaling
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000055
name: PKA-Bad signaling
is_a: IEV:0000054 ! Bad inactivation signaling

[Term]
id: IEV:0000056
name: RSK-Bad signaling
is_a: IEV:0000054 ! Bad inactivation signaling
relationship: part_of IEV:0000126 ! Insulin receptor signaling pathway (through Shc mediated signaling)
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000059
name: TGF beta super family signaling pathway (through p38 cascade)
is_a: IEV:0000090 ! TGF beta super family signaling pathway
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0000060
name: Grb2-Sos-Ras-PI3K signaling
is_a: IEV:0001258 ! Ras mediated signaling
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000061
name: Phosphorylation of 4EBP by TOR of TORC1 in cytosol
exact_synonym: "Phosphorylation of 4EBP by mTOR in cytosol" []
exact_synonym: "Phosphorylation of 4EBP by TOR of TOR:LST8:Raptor in cytosol" []
xref_analog: IMR:0000898
xref_analog: IMR:0002721
xref_analog: IMR:0002730
xref_analog: IMR:0002736
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000112 ! AKT(PKB)-TOR signaling

[Term]
id: IEV:0000062
name: JAK STAT signaling (Angiotensin induced)
exact_synonym: "JAK STAT signaling pathway (Angiotensin induced)" []
xref_analog: PubMed:16870827
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000063
name: IL1 signaling (through IKK-NF-kappaB cascade)
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000110 ! IL1 signaling pathway
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000064
name: Organic chemical treatment
is_a: IEV:0000028 ! Chemical treatment

[Term]
id: IEV:0000065
name: PLC beta signaling
is_a: IEV:0000471 ! PLC signaling
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
relationship: part_of IEV:0000773 ! Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o and PLCbeta)
relationship: part_of IEV:0002633 ! Heterotrimeric GPCR signaling pathway (through Angiotensin and G alpha q)
relationship: part_of IEV:0002653 ! Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)

[Term]
id: IEV:0000066
name: CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
exact_synonym: "CD4 T cell receptor signaling pathway (through PLC gamma, PKC and IKK-NF-kappaB cascade)" []
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000460 ! T cell receptor signaling pathway

[Term]
id: IEV:0000067
name: Phosphorylation of S6K1 by TOR of TORC1 in cytosol
exact_synonym: "Activation of p70S6K by mTOR" []
exact_synonym: "Phosphorylation of S6K1 by TOR of TOR:LST8:Raptor in cytosol" []
xref_analog: IMR:0002721
xref_analog: IMR:0002730
xref_analog: IMR:0002736
xref_analog: IMR:0002798
is_a: IEV:0003638 ! Phosphorylation of p70S6K by TOR of TORC1 in cytosol

[Term]
id: IEV:0000068
name: Translocation of Notch (NIC) from plasma membrane to cytosol
xref_analog: IMR:0100712
xref_analog: PubMed:14985712
is_a: IEV:0000508 ! Translocation from plasma membrane to cytosol
relationship: part_of IEV:0001171 ! Nuclear import of Notch (NIC) from the plasma membrane

[Term]
id: IEV:0000069
name: Cellular event
is_a: IEV:0000003 ! Biological event

[Term]
id: IEV:0000070
name: Apoptosis (Inhibition of cell survival)
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposition of phosphatidylserine." [GO:0006915]
exact_synonym: "apoptotic cell death" []
exact_synonym: "apoptotic programmed cell death" []
exact_synonym: "programmed cell death by apoptosis" []
xref_analog: GO:0006915
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000101 ! Programmed cell death

[Term]
id: IEV:0000071
name: Molecular event
is_a: IEV:0000003 ! Biological event

[Term]
id: IEV:0000072
name: Dormancy
def: "The process by which a dormant state is induced, maintained and broken. Dormancy is characterized by a suspension of physiological activity." [GO:0022611]
xref_analog: GO:0022611
is_a: IEV:0000083 ! Development
is_a: IEV:0001330 ! Physiological event

[Term]
id: IEV:0000073
name: Bud dormancy
is_a: IEV:0000072 ! Dormancy

[Term]
id: IEV:0000074
name: Seed dormancy
def: "The process by which a dormant state is induced and maintained in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated once dormancy is broken." [GO:0010162]
xref_analog: GO:0010162
is_a: IEV:0000072 ! Dormancy
relationship: part_of IEV:0001329 ! Seed development

[Term]
id: IEV:0000075
name: Disease
is_a: IEV:0000082 ! Organism event

[Term]
id: IEV:0000076
name: Cell proliferation
def: "The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population." [GO:0008283]
xref_analog: GO:0008283
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0000077
name: Cell cycle
def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GO:0007049]
xref_analog: GO:0007049
xref_analog: MeSH:D002453
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0000078
name: Cell cycle arrest
def: "The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M)." [GO:0007050]
exact_synonym: "arrest of cell cycle progression" []
exact_synonym: "cessation of cell cycle" []
exact_synonym: "termination of cell cycle" []
xref_analog: GO:0007050
is_a: IEV:0000366 ! Cell cycle process

[Term]
id: IEV:0000079
name: Cytokinesis
def: "A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components." [GO:0000910]
xref_analog: GO:0000910
is_a: IEV:0003382 ! Cell division

[Term]
id: IEV:0000080
name: Transdifferentiation
def: "The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate." [GO:0060290]
xref_analog: GO:0060290
is_a: IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0000081
name: Epithelial to mesenchymal transdifferentiation
is_a: IEV:0000080 ! Transdifferentiation

[Term]
id: IEV:0000082
name: Organism event
is_a: IEV:0000003 ! Biological event

[Term]
id: IEV:0000083
name: Development
xref_analog: GO:0032502
is_a: IEV:0000082 ! Organism event

[Term]
id: IEV:0000084
name: Adipocyte differentiation
def: "The process whereby a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [GO:0045444]
exact_synonym: "adipocyte cell differentiation" [GO:0045444]
exact_synonym: "adipose cell differentiation" [GO:0045444]
exact_synonym: "fat cell differentiation" [GO:0045444]
xref_analog: GO:0045444
is_a: IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0000085
name: Myoblast differentiation
def: "The process whereby a relatively unspecialized cell acquires specialized features of a myoblast, a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [GO:0045445]
xref_analog: GO:0045445
is_a: IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0000086
name: Osteoblast differentiation
def: "Differentiation of the osteoblast; which is the mesodermal cell that gives rise to bone." [GO:0001649]
xref_analog: GO:0001649
is_a: IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0000087
name: Inhibition of Adipocyte differentiation
def: "Any process that stops, prevents or reduces the rate, frequency or extent of adipocyte differentiation." [GO:0045599]
exact_synonym: "negative regulation of fat cell differentiation" [GO:0045599]
xref_analog: GO:0045599
relationship: negatively_regulates IEV:0000084 ! Adipocyte differentiation

[Term]
id: IEV:0000088
name: Negative regulation of myoblast differentiation
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [GO:0045662]
xref_analog: GO:0045662
relationship: negatively_regulates IEV:0000085 ! Myoblast differentiation

[Term]
id: IEV:0000089
name: Negative regulation of osteoblast differentiation
def: "Any process that stops, prevents or reduces the rate, frequency or extent of osteoblast differentiation." [GO:0045668]
xref_analog: GO:0045668
relationship: negatively_regulates IEV:0000086 ! Osteoblast differentiation

[Term]
id: IEV:0000090
name: TGF beta super family signaling pathway
is_a: IEV:0001842 ! Signaling pathway
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000081 ! Epithelial to mesenchymal transdifferentiation
relationship: part_of IEV:0000091 ! Cell growth
relationship: part_of IEV:0000092 ! Cytoskeleton organization
relationship: part_of IEV:0000093 ! Lamellipodium biogenesis
relationship: part_of IEV:0000094 ! Membrane ruffling
relationship: part_of IEV:0000095 ! Stress fiber formation
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000099 ! Tumorigenesis
relationship: part_of IEV:0000578 ! Tissue regeneration

[Term]
id: IEV:0000091
name: Cell growth
def: "The process by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GO:0016049]
exact_synonym: "cellular growth" []
exact_synonym: "growth of cell" []
xref_analog: GO:0016049
is_a: IEV:0000069 ! Cellular event
is_a: IEV:0000142 ! Growth

[Term]
id: IEV:0000092
name: Cytoskeleton organization
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GO:0007010]
exact_synonym: "cytoskeleton organisation" []
xref_analog: GO:0007010
is_a: IEV:0001322 ! Organelle organization

[Term]
id: IEV:0000093
name: Lamellipodium biogenesis
def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GO:0030032]
xref_analog: GO:0030032
is_a: IEV:0001320 ! Cellular component organization

[Term]
id: IEV:0000094
name: Membrane ruffling
is_a: IEV:0001325 ! Cell morphogenesis

[Term]
id: IEV:0000095
name: Stress fiber formation
def: "Assembly of a stress fiber, the bundle of microfilaments and other proteins found in fibroblasts." [GO:0043149]
xref_analog: GO:0043149
is_a: IEV:0001324 ! Actin filament organization

[Term]
id: IEV:0000096
name: Ecodormancy
relationship: part_of IEV:0000073 ! Bud dormancy

[Term]
id: IEV:0000097
name: Cell death
def: "The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GO:0008219]
xref_analog: GO:0008219
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0000098
name: Immune response
def: "Any process involved in the immunological reaction of an organism to an immunogenic stimulus." [GO:0006955]
xref_analog: GO:0006955
is_a: IEV:0001332 ! Response to stimulus

[Term]
id: IEV:0000099
name: Tumorigenesis
exact_synonym: "oncogenesis" []
is_a: IEV:0000082 ! Organism event

[Term]
id: IEV:0000101
name: Programmed cell death
def: "Cell death resulting from activation of endogenous cellular processes." [GO:0012501]
xref_analog: GO:0012501
is_a: IEV:0000097 ! Cell death

[Term]
id: IEV:0000102
name: M phase
def: "A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division." [GO:0000279]
xref_analog: GO:0000279
is_a: IEV:0000366 ! Cell cycle process

[Term]
id: IEV:0000103
name: Cell motion
def: "Any process involved in the controlled movement of a cell." [GO:0006928]
exact_synonym: "cell movement" []
xref_analog: GO:0006928
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0000104
name: Cell migration
def: "The orderly movement of cells from one site to another, often during the development of a multicellular organism." [GO:0016477]
xref_analog: GO:0016477
is_a: IEV:0000103 ! Cell motion

[Term]
id: IEV:0000105
name: Cell adhesion
def: "The attachment of a cell, either to another cell or to the extracellular matrix, via cell adhesion molecules." [GO:0007155]
xref_analog: GO:0007155
xref_analog: KEGG:hsa04510
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0000106
name: Behavior
def: "The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GO:0007610]
xref_analog: GO:0007610
is_a: IEV:0000082 ! Organism event
is_a: IEV:0001332 ! Response to stimulus

[Term]
id: IEV:0000107
name: B cell receptor signaling pathway
def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell." [GO:0050853]
exact_synonym: "B lymphocyte receptor signaling pathway" [GO:0050853]
exact_synonym: "B-cell receptor signaling pathway" [GO:0050853]
exact_synonym: "B-lymphocyte receptor signaling pathway" [GO:0050853]
xref_analog: GO:0050853
xref_analog: KEGG:hsa04662
xref_analog: PubMed:14632637
is_a: IEV:0001842 ! Signaling pathway
relationship: part_of IEV:0000098 ! Immune response

[Term]
id: IEV:0000108
name: Toll-like receptor signaling pathway (p38 cascade)
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000462 ! Toll-like receptor signaling pathway

[Term]
id: IEV:0000109
name: Negative regulation of BAD inactivation signaling
exact_synonym: "Negative regulation of BAD phosphorylation signaling" []
is_obsolete: true

[Term]
id: IEV:0000110
name: IL1 signaling pathway
xref_analog: REACT:22272.1
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0000111
name: Skeletal muscle hypertrophy
is_a: IEV:0000576 ! Organ morphogenesis

[Term]
id: IEV:0000112
name: AKT(PKB)-TOR signaling
exact_synonym: "AKT(PKB)-mTOR signaling" []
exact_synonym: "mTOR signaling" []
xref_analog: KEGG:hsa04150
is_a: IEV:0001699 ! AKT signaling
relationship: part_of IEV:0000111 ! Skeletal muscle hypertrophy
relationship: part_of IEV:0000452 ! Insulin receptor signaling pathway (through IRS mediated signaling)

[Term]
id: IEV:0000113
name: TNFR1 signaling pathway (through NF-kappaB cascade)
alt_id: IEV:0000119
exact_synonym: "TNFR2 Signaling Pathway" []
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0002408 ! TNFR1 signaling pathway

[Term]
id: IEV:0000114
name: TNFR1 signaling pathway (through caspase cascade)
exact_synonym: "TNF signaling" []
xref_analog: GO:0008624
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
xref_analog: REACT:1432.1
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0002408 ! TNFR1 signaling pathway

[Term]
id: IEV:0000115
name: ERK cascade
def: "A cascade of protein kinase activities, culminating in the phosphorylation and activation of either the ERK1 or ERK2 kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases.\nNote that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2, not other ERK kinases." [GO:0070371]
exact_synonym: "ERK1 and ERK2 cascade" []
exact_synonym: "ERK1/2 cascade" []
xref_analog: PubMed:14734786
is_a: IEV:0000445 ! MAPKKK cascade
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000091 ! Cell growth
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000126 ! Insulin receptor signaling pathway (through Shc mediated signaling)
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000452 ! Insulin receptor signaling pathway (through IRS mediated signaling)
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000865 ! EGF receptor signaling pathway
relationship: part_of IEV:0000866 ! NGF receptor signaling pathway
relationship: part_of IEV:0001234 ! TPO signaling pathway (through Sos, Ras and Erk cascade)
relationship: part_of IEV:0001257 ! PDGF receptor signaling pathway
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0002626 ! FGF receptor signaling pathway
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway
relationship: part_of IEV:0002632 ! VEGF receptor signaling pathway
relationship: part_of IEV:0002653 ! Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)
relationship: part_of IEV:0003405 ! FGFR1 signaling pathway

[Term]
id: IEV:0000116
name: Negative feedback regulation of Ras-Raf-MAPK signaling by Sprouty (Drosophila)
def: "OBSOLETE: remap to 'Negative feedback regulation of Ras-Raf-MAPK signaling by Sprouty' IEV:0003547." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0000117
name: Negative feedback regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
def: "OBSOLETE: remap to 'Negative feedback regulation of Ras-Raf-MAPK signaling by spred' IEV:0003546." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0000118
name: SUMOylation
def: "Reversible reaction that create a covalent bond between a C-terminus G of an ubiquitine like sumo protein and a K residue of the target." [MI:0566]
xref_analog: MI:0566
is_a: IEV:0000912 ! Ligation

[Term]
id: IEV:0000120
name: TPO signaling pathway
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0000121
name: Rhodopsin mediated signaling pathway
def: "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon." [GO:0016056]
xref_analog: GO:0016056
is_a: IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0000122
name: Proteasome mediated protein degradation signaling
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GO:0043161]
exact_synonym: "proteasomal pathway" []
exact_synonym: "proteasomal ubiquitin-dependent protein breakdown" []
exact_synonym: "proteasomal ubiquitin-dependent protein catabolic process" []
exact_synonym: "proteasomal ubiquitin-dependent protein catabolism" []
exact_synonym: "proteasomal ubiquitin-dependent protein degradation" []
xref_analog: GO:0043161
is_a: IEV:0001842 ! Signaling pathway
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000123
name: PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0001257 ! PDGF receptor signaling pathway

[Term]
id: IEV:0000124
name: Integrin signaling pathway
def: "Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands." [GO:0007229]
xref_analog: GO:0007229
xref_analog: KEGG:hsa04510
is_a: IEV:0001842 ! Signaling pathway
relationship: part_of IEV:0002534 ! Filopodium formation

[Term]
id: IEV:0000125
name: Glutamate receptor signaling pathway
def: "The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor." [GO:0007215]
exact_synonym: "glutamate signaling pathway" []
xref_analog: GO:0007215
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0000126
name: Insulin receptor signaling pathway (through Shc mediated signaling)
exact_synonym: "Insulin receptor signaling pathway (through ERK cascade)" []
is_a: IEV:0000487 ! Insulin receptor signaling pathway
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000127
name: Integrin signaling pathway (through ERK cascade)
xref_analog: KEGG:hsa04510
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000092 ! Cytoskeleton organization
relationship: part_of IEV:0000095 ! Stress fiber formation
relationship: part_of IEV:0000104 ! Cell migration
relationship: part_of IEV:0000124 ! Integrin signaling pathway
relationship: part_of IEV:0000397 ! Embryonic development

[Term]
id: IEV:0000128
name: Caspase Cascade
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0001842 ! Signaling pathway
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0000129
name: Oligomerization of Bax in cytosol
exact_synonym: "Oligomerization of BAX at the mitochondrial membrane" []
xref_analog: IMR:0000453
xref_analog: REACT:341.2
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000167 ! Bax activation signaling

[Term]
id: IEV:0000130
name: Cyclin E degradation signaling
xref_analog: GO:0008054
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
is_a: IEV:0000391 ! Negative regulation of G1-S-phase transition

[Term]
id: IEV:0000131
name: Phosphorylation of Bad by RSK in cytosol
xref_analog: IMR:0000248
xref_analog: IMR:0100288
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000056 ! RSK-Bad signaling

[Term]
id: IEV:0000132
name: Binding of SOCS and JAK in cytosol
xref_analog: IMR:0000213
xref_analog: IMR:0000460
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000143 ! Negative feedback regulation of JAK STAT pathway by (binding of SOCS and JAK)

[Term]
id: IEV:0000133
name: Growth hormone signaling pathway (JAK2, STAT5)
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000134
name: IL4 signaling pathway (JAK1, JAK3, STAT6)
is_a: IEV:0000044 ! JAK STAT pathway
relationship: part_of IEV:0003871 ! B cell proliferation
relationship: part_of IEV:0003873 ! Th2 cell proliferation
relationship: part_of IEV:0003877 ! Th2 cell differentiation

[Term]
id: IEV:0000135
name: IL3 signaling pathway (JAK1, JAK2, STAT5)
is_a: IEV:0000044 ! JAK STAT pathway
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000136
name: IL2 signaling (JAK1, JAK3, STAT5)
exact_synonym: "IL2 signaling pathway (JAK1, JAK3, STAT5)" []
xref_analog: PubMed:8700888
is_a: IEV:0000044 ! JAK STAT pathway
relationship: part_of IEV:0003874 ! Th1 cell proliferation
relationship: part_of IEV:0003880 ! NK cell activation

[Term]
id: IEV:0000138
name: IL12 signaling pathway (JAK2, TYK2, STAT4)
xref_analog: PubMed:10415122
is_a: IEV:0000044 ! JAK STAT pathway
relationship: part_of IEV:0003876 ! Th1 cell differentiation

[Term]
id: IEV:0000139
name: IL10 signaling (JAK1, TYK2, STAT3)
exact_synonym: "IL10 signaling pathway (JAK1, TYK2, STAT3)" []
xref_analog: PubMed:10433356
is_a: IEV:0000044 ! JAK STAT pathway
relationship: part_of IEV:0003873 ! Th2 cell proliferation

[Term]
id: IEV:0000140
name: IL7 signaling (JAK1, JAK3, STAT5)
exact_synonym: "IL7 signaling  pathway (JAK1, JAK3, STAT5)" []
is_a: IEV:0000044 ! JAK STAT pathway
relationship: part_of IEV:0003875 ! T cell differentiation

[Term]
id: IEV:0000141
name: Flower development
def: "The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem." [GO:0009908]
exact_synonym: "Flowering" []
xref_analog: GO:0009908
is_a: IEV:0000398 ! Post embryonic development
is_a: IEV:0003797 ! Reproductive structure development

[Term]
id: IEV:0000142
name: Growth
def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GO:0040007]
xref_analog: GO:0040007
is_a: IEV:0000082 ! Organism event

[Term]
id: IEV:0000143
name: Negative feedback regulation of JAK STAT pathway by (binding of SOCS and JAK)
xref_analog: IMR:0000213
xref_analog: IMR:0000460
is_a: IEV:0002228 ! Negative feedback regulation of JAK STAT pathway

[Term]
id: IEV:0000145
name: Regulation pathway
is_a: IEV:0000001 ! Pathway

[Term]
id: IEV:0000146
name: Dephosphorylation of Jak by PTP in cytosol
xref_analog: IMR:0000213
xref_analog: IMR:0000273
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0001844 ! Negative regulation of (Phosphorylation of JAK) in JAK STAT pathway

[Term]
id: IEV:0000147
name: Dephosphorylation of cytokine receptor by PTP in cytosol
xref_analog: IMR:0000095
xref_analog: IMR:0000273
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0001843 ! Negative regulation of (Phosphorylation of cytokine receptor) in JAK STAT pathway

[Term]
id: IEV:0000148
name: Negative regulation of transcription by PIAS
xref_analog: IMR:0002914
xref_analog: PubMed:15021887
is_a: IEV:0001838 ! Negative regulation of transcription

[Term]
id: IEV:0000149
name: Dephosphorylation of STAT dimer by PTP in cytosol
xref_analog: IMR:0000273
xref_analog: IMR:0000374
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0001845 ! Negative regulation of (Phosphorylation of STAT) in JAK STAT pathway
relationship: part_of IEV:0002245 ! Negative regulation of (Dimerization of STAT) in JAK STAT pathway

[Term]
id: IEV:0000150
name: Negative regulation of JAK STAT pathway
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GO:0046426]
xref_analog: GO:0046426
is_a: IEV:0000550 ! Regulation of JAK STAT pathway
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000151
name: Negative feedback regulation of JAK STAT pathway by (binding of SOCS and cytokine receptor)
xref_analog: IMR:0000095
xref_analog: IMR:0000460
is_a: IEV:0002228 ! Negative feedback regulation of JAK STAT pathway

[Term]
id: IEV:0000152
name: Binding of SOCS and Cytokine receptor in cytosol
xref_analog: IMR:0000095
xref_analog: IMR:0000460
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000151 ! Negative feedback regulation of JAK STAT pathway by (binding of SOCS and cytokine receptor)

[Term]
id: IEV:0000153
name: Cell survival (Inhibition of apoptosis)
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0000154
name: Binding of TGF beta superfamily and TGF beta superfamily receptor I/II in extracellular
xref_analog: IMR:0000036
xref_analog: IMR:0000092
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000155
name: Transcription by R-Smad:Smad4 in nucleus
xref_analog: IMR:0000371
xref_analog: IMR:0100315
is_a: IEV:0001145 ! Transcription by Smad complex in nucleus
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000156
name: Binding of R-Smad:Smad4 complex, Coactivator and responsive element in inner space of nucleus
xref_analog: IGS:0000028
xref_analog: IMR:0000371
xref_analog: IMR:0000424
xref_analog: IMR:0100315
is_a: IEV:0002098 ! Binding of transcription factor and responsive element in inner space of nucleus
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000157
name: Phosphorylation of R-Smad by TGF beta receptor I in cytosol
xref_analog: GO:0007182
xref_analog: IMR:0000371
xref_analog: IMR:0000710
is_a: IEV:0003584 ! Phosphorylation of R-Smad by TGF beta superfamily receptor I in cytosol

[Term]
id: IEV:0000158
name: Nuclear import of R-Smad:Smad4
xref_analog: GO:0007184
xref_analog: IMR:0000371
xref_analog: IMR:0100315
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000159
name: Complex formation of R-Smad and Smad4 in cytosol
xref_analog: GO:0007183
xref_analog: IMR:0000371
xref_analog: IMR:0100315
is_a: IEV:0003586 ! Complex formation of R-Smad and Co-Smad in cytosol

[Term]
id: IEV:0000160
name: Phosphorylation of TGF-b receptor I by TGF beta receptor II in cytosol
xref_analog: IMR:0000710
xref_analog: IMR:0000712
is_a: IEV:0003583 ! Phosphorylation of TGF beta superfamily receptor I by TGF beta superfamily receptor II in cytosol
relationship: part_of IEV:0002339 ! TGF beta signaling pathway (through TAK1)

[Term]
id: IEV:0000161
name: Fas signaling pathway (through caspase cascade)
exact_synonym: "FasL/ CD95L signaling" []
xref_analog: GO:0008624
xref_analog: REACT:900.1
is_a: IEV:0001397 ! Fas signaling pathway
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0000162
name: Estrogen receptor signaling pathway
def: "Any series of molecular signals generated as a consequence of an estrogen binding to its receptor." [GO:0030520]
xref_analog: GO:0030520
is_a: IEV:0001231 ! Steroid receptor signaling pathway
relationship: part_of IEV:0000077 ! Cell cycle

[Term]
id: IEV:0000163
name: fMLP signaling pathway
is_a: IEV:0000661 ! GPCR signaling pathway
relationship: part_of IEV:0000098 ! Immune response

[Term]
id: IEV:0000164
name: Notch signaling pathway
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell." [GO:0007219]
exact_synonym: "N signaling pathway" [GO:0007219]
xref_analog: GO:0007219
xref_analog: KEGG:hsa04330
xref_analog: PubMed:14985712
is_a: IEV:0001842 ! Signaling pathway
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000091 ! Cell growth
relationship: part_of IEV:0000397 ! Embryonic development
relationship: part_of IEV:0002609 ! Induction
relationship: part_of IEV:0002610 ! Lateral inhibition

[Term]
id: IEV:0000165
name: p53 signaling pathway (through p21)
is_a: IEV:0000391 ! Negative regulation of G1-S-phase transition
is_a: IEV:0001096 ! Negative regulation of S phase
is_a: IEV:0001103 ! p53 signaling pathway
relationship: part_of IEV:0000077 ! Cell cycle
relationship: part_of IEV:0000872 ! DNA repair
relationship: part_of IEV:0001106 ! G1 phase

[Term]
id: IEV:0000166
name: AKT(PKB)-Bad signaling
exact_synonym: "PI3K-AKT(PKB)-Bad signaling" []
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000054 ! Bad inactivation signaling
is_a: IEV:0001699 ! AKT signaling
relationship: part_of IEV:0000135 ! IL3 signaling pathway (JAK1, JAK2, STAT5)
relationship: part_of IEV:0000140 ! IL7 signaling (JAK1, JAK3, STAT5)
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0000452 ! Insulin receptor signaling pathway (through IRS mediated signaling)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000866 ! NGF receptor signaling pathway
relationship: part_of IEV:0000867 ! EPO signaling pathway
relationship: part_of IEV:0001262 ! Rho-PI5K signaling
relationship: part_of IEV:0002632 ! VEGF receptor signaling pathway
relationship: part_of IEV:0003559 ! IGF1 signaling pathway

[Term]
id: IEV:0000167
name: Bax activation signaling
exact_synonym: "Activation, translocation and oligomerization of BAX" []
exact_synonym: "Bax dimerization signaling" []
xref_analog: GO:0008633
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
xref_analog: REACT:584.3
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0000168
name: Endodormancy
relationship: part_of IEV:0000073 ! Bud dormancy

[Term]
id: IEV:0000169
name: Oxidation in unidentified cellular location
is_a: IEV:0000382 ! Oxidation

[Term]
id: IEV:0000170
name: Binding of Bad and Bcl-2/Bcl-xL in mitochondria membrane
exact_synonym: "BAD displaces tBID from BCL-2 sequestration" []
xref_analog: IMR:0100261
xref_analog: IMR:0100288
xref_analog: IMR:0100293
xref_analog: REACT:1062.2
is_a: IEV:0000033 ! Binding in mitochondria membrane
relationship: part_of IEV:0001667 ! Bcl-2/Bcl-xL inactivation signaling

[Term]
id: IEV:0000171
name: Oxidation in cytosol
is_a: IEV:0000382 ! Oxidation

[Term]
id: IEV:0000172
name: Paradormancy
relationship: part_of IEV:0000073 ! Bud dormancy

[Term]
id: IEV:0000173
name: Negative regulation of Fas signaling pathway
is_a: IEV:0000544 ! Regulation of Fas signaling pathway
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0001397 ! Fas signaling pathway

[Term]
id: IEV:0000174
name: Binding outside the mitochondria membrane
is_a: IEV:0000013 ! Binding in cytosol
is_a: IEV:0000033 ! Binding in mitochondria membrane

[Term]
id: IEV:0000175
name: Translocation from mitochondria membrane to cytosol
is_a: IEV:0000985 ! Translocation from mitochondria to cytosol

[Term]
id: IEV:0000176
name: Permeabilization of mitochondria and Translocation of Cyt c from mitochondria to cytosol
exact_synonym: "Release of Cytochrome c from mitochondria" []
xref_analog: IMR:0001206
xref_analog: REACT:535.3
is_a: IEV:0000984 ! Permeabilization of mitochondria and Translocation of cytochrome c/SMAC from mitochondria to cytosol

[Term]
id: IEV:0000177
name: Negative regulation of Caspase cascade (through mitochondria)
is_a: IEV:0001018 ! Regulation of Caspase cascade (through mitochondria)
is_a: IEV:0001019 ! Negative regulation of Caspase cascade
relationship: negatively_regulates IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0000178
name: Binding of Cyt c and Apaf1 in cytosol
exact_synonym: "Cytochrome C Binds to Apaf-1" []
xref_analog: IMR:0001204
xref_analog: IMR:0001206
xref_analog: REACT:1640.2
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000989 ! Apoptosome formation in cytosol

[Term]
id: IEV:0000179
name: Binding of Cyt c and Bcl-2/Bcl-xL
xref_analog: IMR:0100261
xref_analog: IMR:0100293
relationship: part_of IEV:0000177 ! Negative regulation of Caspase cascade (through mitochondria)

[Term]
id: IEV:0000180
name: Phosphorylation of Bcl-2 in cytosol
xref_analog: IMR:0100261
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000181
name: Internalization of TGF beta receptor
xref_analog: IMR:0000092
is_a: IEV:0001505 ! Receptor internalization

[Term]
id: IEV:0000182
name: Gene expression
def: "The process by which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GO:0010467]
xref_analog: GO:0010467
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000183
name: Transcription
def: "The synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GO:0006350]
xref_analog: GO:0006350
is_a: IEV:0001886 ! Molecular interaction
relationship: part_of IEV:0000182 ! Gene expression

[Term]
id: IEV:0000184
name: Hydrolysis
def: "EC:3 catalyzed process" [EC:3.-.-.-]
exact_synonym: "lyase activity" []
xref_analog: EC:3.-.-.-
xref_analog: GO:0016787
is_a: IEV:0002721 ! enzymatic reaction

[Term]
id: IEV:0000185
name: Environmental event
is_a: IEV:0000000 ! Event

[Term]
id: IEV:0000186
name: Binding in unidentified cellular location
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0000187
name: Phosphorylation in unidentified cellular location
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0000188
name: Negative regulation of NF-kappaB signaling (cytoplasmic sequestering)
is_a: IEV:0000552 ! Regulation of NF-kappaB signaling (cytoplasmic sequestering)
is_a: IEV:0001670 ! Negative signal transduction regulation pathway

[Term]
id: IEV:0000189
name: Binding of NF-kappaB and specific modules in cytosol
xref_analog: IMR:0000382
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000188 ! Negative regulation of NF-kappaB signaling (cytoplasmic sequestering)

[Term]
id: IEV:0000190
name: Induction of (Para) dormancy
relationship: part_of IEV:0000172 ! Paradormancy

[Term]
id: IEV:0000191
name: Binding of IL1 and IL1R complex in extracellular
xref_analog: GO:0004908
xref_analog: IMR:0000011
xref_analog: IMR:0000120
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000192
name: Binding of MyD88 and IRAK1 in cytosol
xref_analog: IMR:0000890
xref_analog: IMR:0100465
is_a: IEV:0000242 ! Binding of MyD88 and IRAK in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000193
name: Binding of IL-1R complex and Tollip in cytosol
xref_analog: IMR:0000120
xref_analog: IMR:0000894
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000194
name: Binding of MyD88 and IRAK4 in cytosol
xref_analog: IMR:0000892
xref_analog: IMR:0100465
is_a: IEV:0000242 ! Binding of MyD88 and IRAK in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000195
name: Binding of IL1-R complex and MyD88 in cytosol
xref_analog: IMR:0000120
xref_analog: IMR:0100465
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000196
name: Binding of Tollip and IRAK1 in cytosol
xref_analog: IMR:0000890
xref_analog: IMR:0000894
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000197
name: Phosphorylation of IRAK1 by IRAK4 in cytosol
xref_analog: IMR:0000890
xref_analog: IMR:0000892
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000198
name: Phosphorylation in plasma membrane
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0000199
name: GDP-GTP exchange in plasma membrane
is_a: IEV:0000223 ! GDP-GTP exchange

[Term]
id: IEV:0000200
name: Binding of IRAK1_p and TRAF6 in cytosol
xref_analog: IMR:0000890
xref_analog: IMR:0100427
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000201
name: Binding of IRAK1:TRAF6 and TAK1:TAB1:TAB2 in cytosol
xref_analog: IMR:0000232
xref_analog: IMR:0000441
xref_analog: IMR:0000890
xref_analog: IMR:0000893
xref_analog: IMR:0100427
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000202
name: Ubiquitination of TRAF6 in cytosol
xref_analog: IMR:0100427
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000203
name: Lyase process in cytosol
is_a: IEV:0000917 ! Lyase process

[Term]
id: IEV:0000204
name: Ubiquitination in unidentified cellular location
is_a: IEV:0000012 ! Ubiquitination

[Term]
id: IEV:0000205
name: Ubiquitination of IRAK1_p in cytosol
xref_analog: IMR:0000890
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000206
name: Proteasome degradation in plasma membrane
is_a: IEV:0000010 ! Proteasome degradation

[Term]
id: IEV:0000207
name: Proteasome degradation of IRAK1_p in cytosol
xref_analog: IMR:0000890
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000208
name: IKK-NF-kappaB cascade
def: "A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase." [GO:0007249]
exact_synonym: "I-kappaB kinase/NF-kappaB cascade" [GO:0007249]
exact_synonym: "NIK-I-kappaB/NF-kappaB cascade" [GO:0007249]
xref_analog: GO:0007249
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
xref_analog: PubMed:15134788
is_a: IEV:0001842 ! Signaling pathway
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000209
name: Phosphorylation of NIK by TAK1 in cytosol
xref_analog: IMR:0000232
xref_analog: IMR:0000242
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000210
name: Proteasome degradation of I-kappaB in cytosol
alt_id: IEV:0001265
exact_synonym: "Proteasome degradation of I-kappaB by 26S proteasome in cytosol" []
xref_analog: IMR:0000464
xref_analog: PubMed:15134788
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade
relationship: part_of IEV:0001264 ! I-kappaB degradation signaling

[Term]
id: IEV:0000211
name: Release of (eco) dormancy
relationship: part_of IEV:0000096 ! Ecodormancy

[Term]
id: IEV:0000212
name: Ubiquitination of I-kappaB_p in cytosol
alt_id: IEV:0001266
exact_synonym: "Ubiquitination of I-kappaB in cytosol" []
xref_analog: IMR:0000464
xref_analog: PubMed:15134788
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade
relationship: part_of IEV:0001264 ! I-kappaB degradation signaling

[Term]
id: IEV:0000213
name: Phosphorylation of I-kappaB_p by IKK complex_p in cytosol
narrow_synonym: "Phosphorylation of I-kappaB_p by IKK complex_p [mammals]" []
xref_analog: GO:0007252
xref_analog: IMR:0000243
xref_analog: IMR:0000464
xref_analog: PubMed:15134788
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000214
name: Binding of NF-kappaB and I-kappaB in cytosol
xref_analog: GO:0007253
xref_analog: IMR:0000382
xref_analog: IMR:0000464
xref_analog: PubMed:15134788
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000215
name: Dissociation of NF-kappaB and I-kappaB in cytosol
narrow_synonym: "Dissociation of NF-kappaB and I-kappaB [mammals]" []
xref_analog: GO:0008588
xref_analog: IMR:0000382
xref_analog: IMR:0000464
xref_analog: PubMed:15134788
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000216
name: Nuclear import of NF-kappaB
def: "The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GO:0042348]
exact_synonym: "NF-kappaB import into nucleus" []
exact_synonym: "NF-kappaB protein-nucleus import" []
exact_synonym: "NF-kappaB transport from cytoplasm to nucleus" []
exact_synonym: "NF-kappaB-nucleus import" []
xref_analog: GO:0042348
xref_analog: IMR:0000382
xref_analog: PubMed:15134788
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000217
name: Binding of NF-kappaB and responsive element in inner space of nucleus
xref_analog: IGS:0000028
xref_analog: IMR:0000382
xref_analog: PubMed:11973130
is_a: IEV:0002098 ! Binding of transcription factor and responsive element in inner space of nucleus
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000783 ! Gene expression by NF-kappaB
relationship: part_of IEV:0003420 ! Gene expression of c-FLIP by NF-kappaB

[Term]
id: IEV:0000218
name: Gene expression of cytokine by NF-kappaB
xref_analog: IMR:0000006
xref_analog: IMR:0000382
is_a: IEV:0000783 ! Gene expression by NF-kappaB
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000219
name: Translation
def: "The chemical reactions and pathways resulting in the formation of a protein. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GO:0006412]
xref_analog: GO:0006412
is_a: IEV:0001886 ! Molecular interaction
relationship: part_of IEV:0000182 ! Gene expression

[Term]
id: IEV:0000221
name: Metabolic reaction
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000222
name: Myristoylation
def: "Reaction that can affect K or G residues." [MI:0214]
xref_analog: MI:0214
is_a: IEV:0002681 ! lipid addition

[Term]
id: IEV:0000223
name: GDP-GTP exchange
def: "GDP+ phosphate = GTP + H2O" [XX:<new dbxref>]
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0000224
name: IL-1 signaling (through JNK cascade)
exact_synonym: "IL1 signaling pathway (through JNK cascade)" []
is_a: IEV:0000110 ! IL1 signaling pathway
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000225
name: Gene expression of cytokine by AP-1
xref_analog: IMR:0000006
xref_analog: IMR:0000414
is_a: IEV:0003387 ! Gene expression by AP-1

[Term]
id: IEV:0000226
name: JNK cascade
def: "A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress." [GO:0007254]
xref_analog: GO:0007254
is_a: IEV:0000445 ! MAPKKK cascade
relationship: part_of IEV:0000062 ! JAK STAT signaling (Angiotensin induced)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
relationship: part_of IEV:0000455 ! TNFR1 signaling pathway (through JNK cascade)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)
relationship: part_of IEV:0000865 ! EGF receptor signaling pathway
relationship: part_of IEV:0001257 ! PDGF receptor signaling pathway
relationship: part_of IEV:0002339 ! TGF beta signaling pathway (through TAK1)
relationship: part_of IEV:0002714 ! Toll-like receptor signaling pathway (through JNK cascade)
relationship: part_of IEV:0003456 ! IMD signaling pathway

[Term]
id: IEV:0000227
name: Phosphorylation of MKK4/7 by MAPKKK in cytosol
def: "The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity in response to phosphorylation by a member of the JUN kinase kinase kinase (JNKKK) family, or another upstream kinase. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress." [GO:0007256]
exact_synonym: "activation of JNKK activity" [GO:0007256]
xref_analog: GO:0007256
xref_analog: IMR:0000229
xref_analog: IMR:0000262
is_a: IEV:0000474 ! Phosphorylation of MAPKK by MAPKKK in cytosol
relationship: part_of IEV:0000226 ! JNK cascade

[Term]
id: IEV:0000228
name: Phosphorylation of JNK by MKK4/7_p in cytosol
xref_analog: GO:0007257
xref_analog: IMR:0000225
xref_analog: IMR:0000262
is_a: IEV:0002095 ! Phosphorylation of JNK by MKK_p in cytosol
relationship: part_of IEV:0000161 ! Fas signaling pathway (through caspase cascade)

[Term]
id: IEV:0000229
name: Nuclear import of JNK_p
xref_analog: IMR:0000225
is_a: IEV:0000480 ! Nuclear import of MAPK (through MAPKKK cascade)
relationship: part_of IEV:0000226 ! JNK cascade

[Term]
id: IEV:0000230
name: Phosphorylation of c-Jun by JNK_p in inner space of nucleus
def: "The process of introducing a phosphoric group into a JUN protein." [GO:0007258]
xref_analog: GO:0007258
xref_analog: IMR:0000225
xref_analog: IMR:0000817
is_a: IEV:0003403 ! Phosphorylation of transcriptional regulator by JNK_p in inner space of nucleus

[Term]
id: IEV:0000231
name: Phosphorylation in nucleus
is_a: IEV:0001735 ! Phosphorylation in cytosol and/or nucleus

[Term]
id: IEV:0000232
name: IL-1 signaling (through p38 cascade)
exact_synonym: "IL1 signaling pathway (through p38 cascade)" []
is_a: IEV:0000110 ! IL1 signaling pathway
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000233
name: Gene expression by transcriptional regulator
xref_analog: IMR:0000369
is_a: IEV:0000182 ! Gene expression
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000234
name: p38 cascade
is_a: IEV:0000445 ! MAPKKK cascade
relationship: part_of IEV:0000108 ! Toll-like receptor signaling pathway (p38 cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)
relationship: part_of IEV:0002339 ! TGF beta signaling pathway (through TAK1)

[Term]
id: IEV:0000235
name: Phosphorylation of p38 by MKK3/6_p in cytosol
xref_analog: IMR:0000226
xref_analog: IMR:0000263
is_a: IEV:0002106 ! Phosphorylation of p38 by MKK_p in cytosol

[Term]
id: IEV:0000236
name: Phosphorylation of MKK3/4/6 by MAPKKK in cytosol
xref_analog: IMR:0000229
xref_analog: IMR:0000263
xref_analog: IMR:0100454
is_a: IEV:0000474 ! Phosphorylation of MAPKK by MAPKKK in cytosol
relationship: part_of IEV:0000234 ! p38 cascade

[Term]
id: IEV:0000237
name: Nuclear import of p38_p
xref_analog: IMR:0000226
is_a: IEV:0000480 ! Nuclear import of MAPK (through MAPKKK cascade)
relationship: part_of IEV:0000234 ! p38 cascade

[Term]
id: IEV:0000238
name: Phosphorylation of transcriptional regulator by p38_p in inner space of nucleus
xref_analog: IMR:0000226
xref_analog: IMR:0000369
is_a: IEV:0000479 ! Phosphorylation of transcriptional regulator by MAPK_p in inner space of nucleus
relationship: part_of IEV:0000234 ! p38 cascade

[Term]
id: IEV:0000239
name: Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000462 ! Toll-like receptor signaling pathway

[Term]
id: IEV:0000240
name: Binding of LPS and TLR4:MD-2:CD14 in extracellular
xref_analog: IMR:0001438
xref_analog: IMR:0001439
xref_analog: IMR:0001440
xref_analog: IMR:0001655
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000241
name: Binding of TLR4:MD-2:CD14 and MyD88 in cytosol
xref_analog: IMR:0001438
xref_analog: IMR:0001439
xref_analog: IMR:0001440
xref_analog: IMR:0100465
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000242
name: Binding of MyD88 and IRAK in cytosol
xref_analog: IMR:0100465
xref_analog: IMR:0100488
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000243
name: Activation of IRAK in cytosol
xref_analog: IMR:0100488
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000244
name: Activation in plasma membrane
is_a: IEV:0000008 ! Activation

[Term]
id: IEV:0000245
name: Inactivation in extracellular
is_a: IEV:0000007 ! Inactivation

[Term]
id: IEV:0000246
name: Inactivation in unidentified cellular location
is_a: IEV:0000007 ! Inactivation

[Term]
id: IEV:0000247
name: Binding of activated IRAK and TRAF6 in cytosol
xref_analog: IMR:0100427
xref_analog: IMR:0100488
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000248
name: Binding of TRAF6 and TAB1:TAB2:TAK1 in cytosol
xref_analog: IMR:0000232
xref_analog: IMR:0000441
xref_analog: IMR:0000893
xref_analog: IMR:0100427
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000249
name: Reduction in cytosol
is_a: IEV:0000916 ! Reduction

[Term]
id: IEV:0000250
name: Phosphorylation of IKK complex by MAPKKK in cytosol
xref_analog: GO:0007250
xref_analog: IMR:0000229
xref_analog: IMR:0000243
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0001379 ! IKK activation signaling

[Term]
id: IEV:0000251
name: Binding of TNF alpha homotrimer and TNFR1 in extracellular
exact_synonym: "TNF Binds TNF-R1" []
xref_analog: IMR:0000025
xref_analog: IMR:0000060
xref_analog: REACT:2096.2
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000114 ! TNFR1 signaling pathway (through caspase cascade)
relationship: part_of IEV:0000455 ! TNFR1 signaling pathway (through JNK cascade)

[Term]
id: IEV:0000253
name: Trimerization of TNFR1 in plasma membrane
exact_synonym: "TNFR1 trimerization" []
xref_analog: IMR:0000060
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000114 ! TNFR1 signaling pathway (through caspase cascade)
relationship: part_of IEV:0000455 ! TNFR1 signaling pathway (through JNK cascade)

[Term]
id: IEV:0000254
name: Binding of TNFR1 trimer and TRADD in cytosol
xref_analog: IMR:0000060
xref_analog: IMR:0100464
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000932 ! Binding of TNFR1, TRADD, TRAF2 and RIP in cytosol

[Term]
id: IEV:0000255
name: Binding of TRADD and TRAF2 in cytosol
xref_analog: IMR:0100423
xref_analog: IMR:0100464
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000932 ! Binding of TNFR1, TRADD, TRAF2 and RIP in cytosol

[Term]
id: IEV:0000256
name: Activation of RIP by TRAF2 in cytosol
xref_analog: IMR:0000269
xref_analog: IMR:0100423
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000257
name: Activation of MEKK3 by RIP in cytosol
xref_analog: IMR:0000269
xref_analog: IMR:0100451
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)

[Term]
id: IEV:0000258
name: Complex formation of TCR-CD3 in plasma membrane
exact_synonym: "TCR-CD3 complex formation" []
xref_analog: IMR:0002372
xref_analog: PubMed:15343367
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000259
name: Binding of antigen, TCR-CD3 complex and CD4 in extracellular
xref_analog: IMR:0000465
xref_analog: IMR:0002372
xref_analog: IMR:0100294
xref_analog: PubMed:15343367
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
relationship: part_of IEV:0001479 ! CD28 signaling

[Term]
id: IEV:0000260
name: Binding of TCR-CD3 complex and Lck in cytosol
xref_analog: IMR:0002372
xref_analog: IMR:0100353
is_a: IEV:0001252 ! Binding of TCR-CD3 complex and non-receptor tyrosine kinase in cytosol

[Term]
id: IEV:0000262
name: Binding of TCR-CD3 complex and Fyn in cytosol
xref_analog: IMR:0002372
xref_analog: IMR:0100352
is_a: IEV:0001252 ! Binding of TCR-CD3 complex and non-receptor tyrosine kinase in cytosol

[Term]
id: IEV:0000263
name: Phosphorylation of LAT by ZAP-70_p in cytosol
xref_analog: IMR:0000221
xref_analog: IMR:0000348
xref_analog: PubMed:15343367
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000264
name: Phosphorylation of Vav by non-receptor tyrosine kinase in cytosol
xref_analog: IMR:0000434
xref_analog: IMR:0000682
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000265
name: Phosphorylation of Vav by PI3K in cytosol
xref_analog: IMR:0000265
xref_analog: IMR:0000434
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000266
name: Phosphorylation of ZAP-70 by Lck_p in cytosol
exact_synonym: "Phosphorylation of ZAP-70 by autophosphorylated Lck in cytosol" []
xref_analog: IMR:0000221
xref_analog: IMR:0100353
xref_analog: PubMed:12040176
is_a: IEV:0000573 ! Phosphorylation of ZAP-70 by non-receptor tyrosine kinase in cytosol

[Term]
id: IEV:0000267
name: Binding of LAT_p and PLC gamma in cytosol
xref_analog: IMR:0000285
xref_analog: IMR:0000348
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000268
name: Hydrolysis of PIP2 by PLC gamma to generate DAG and IP3 in cytosol
xref_analog: IMR:0000285
xref_analog: IMR:0001350
xref_analog: IMR:0100027
xref_analog: IMR:0100028
is_a: IEV:0000472 ! Hydrolysis of PIP2 by PLC to generate DAG and IP3 in cytosol
relationship: part_of IEV:0000467 ! PLC gamma signaling
relationship: part_of IEV:0002626 ! FGF receptor signaling pathway
relationship: part_of IEV:0002632 ! VEGF receptor signaling pathway

[Term]
id: IEV:0000269
name: Hydrolysis in plasma membrane
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0000270
name: Binding of DAG and PKC and active conformational change of PKC in cytosol
xref_analog: IMR:0000245
xref_analog: IMR:0100027
xref_analog: PubMed:7499357
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000779 ! PKC activation signaling
relationship: part_of IEV:0002484 ! Activation of PKC by DAG in cytosol

[Term]
id: IEV:0000272
name: Binding of IP3 and IP3R and IP3R opening
xref_analog: IMR:0000084
xref_analog: IMR:0100028
is_a: IEV:0000770 ! Channel opening/closing in the ER membrane
is_a: IEV:0001037 ! Binding outside the ER membrane
relationship: part_of IEV:0000772 ! Cytosolic calcium ion concentration elevation (through IP3 receptor)

[Term]
id: IEV:0000273
name: Binding in ER membrane
is_a: IEV:0001035 ! Binding in ER

[Term]
id: IEV:0000274
name: Calcium ion transport from ER to cytosol through calcium ion channel
xref_analog: IMR:0000499
xref_analog: IMR:0100031
is_a: IEV:0000739 ! Ion transport through ion channel
is_a: IEV:0001943 ! Translocation from ER to cytosol
relationship: part_of IEV:0000772 ! Cytosolic calcium ion concentration elevation (through IP3 receptor)

[Term]
id: IEV:0000276
name: Heterotrimeric GPCR signaling pathway (through PACAP, G alpha s and adenylate cyclase, cAMP and PKA)
is_a: IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)

[Term]
id: IEV:0000277
name: Trimerization of MALT1:CARMA1:BCL10 in cytosol
xref_analog: IMR:0002655
xref_analog: IMR:0002658
xref_analog: IMR:0002662
xref_analog: PubMed:11973130
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0000278
name: Binding of CD28 and CD80/CD86 in extracellular
xref_analog: IMR:0000473
xref_analog: IMR:0002950
xref_analog: ISBN:081533642X
xref_analog: PubMed:15343367
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001479 ! CD28 signaling

[Term]
id: IEV:0000279
name: Reduction in unidentified cellular location
is_a: IEV:0000916 ! Reduction

[Term]
id: IEV:0000280
name: CD4 T cell receptor signaling (through Ras and ERK cascade)
exact_synonym: "CD4 T cell receptor signaling pathway (through Ras and ERK cascade)" []
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000460 ! T cell receptor signaling pathway

[Term]
id: IEV:0000281
name: CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
exact_synonym: "CD4 T cell receptor signaling pathway (through Vav, Rac and JNK cascade)" []
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000460 ! T cell receptor signaling pathway
relationship: part_of IEV:0002258 ! Actin filament reorganization during cell cycle

[Term]
id: IEV:0000282
name: Activation of TAK1 in cytosol
xref_analog: IMR:0000232
is_a: IEV:0000020 ! Activation in cytosol

[Term]
id: IEV:0000283
name: Binding of RTK and PLC gamma in cytosol
xref_analog: IMR:0000063
xref_analog: IMR:0000285
is_a: IEV:0003822 ! Binding of PLC gamma and tyrosine kinase in cytosol
relationship: part_of IEV:0000830 ! RTK signaling pathway

[Term]
id: IEV:0000284
name: Binding of PLC and PIP3 in cytosol
xref_analog: IMR:0000284
xref_analog: IMR:0001352
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000471 ! PLC signaling

[Term]
id: IEV:0000286
name: Phosphorylation of PLC gamma by non-receptor tyrosine kinase in cytosol
alt_id: IEV:0000285
exact_synonym: "Phosphorylation of PLC gamma by syk" []
xref_analog: IMR:0000285
xref_analog: IMR:0000682
xref_analog: PubMed:14993283
is_a: IEV:0001288 ! Phosphorylation of PLC by non-receptor tyrosine kinase in cytosol
is_a: IEV:0003817 ! Phosphorylation of PLC gamma by tyrosine kinase in cytosol

[Term]
id: IEV:0000287
name: Negative regulation of PLC gamma signaling (through LAT)
is_a: IEV:0000554 ! Regulation of PLC gamma signaling
is_a: IEV:0001408 ! Negative regulation of PLC signaling
is_a: IEV:0001797 ! Negative regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: negatively_regulates IEV:0000467 ! PLC gamma signaling

[Term]
id: IEV:0000288
name: Phosphorylation of PIP2 by PI3K in plasma membrane
xref_analog: IMR:0000265
xref_analog: IMR:0001350
is_a: IEV:0000198 ! Phosphorylation in plasma membrane
relationship: part_of IEV:0000287 ! Negative regulation of PLC gamma signaling (through LAT)
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001484 ! AKT(PKB) activation signaling
relationship: part_of IEV:0002252 ! Negative regulation of (Phosphorylation of PIP2 by PI3K)

[Term]
id: IEV:0000289
name: Binding of LAT_p and Gads in cytosol
xref_analog: IMR:0000348
xref_analog: IMR:0000741
xref_analog: PubMed:15343367
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000291
name: Activation of IKK complex by PKC theta in cytosol
def: "The Physical Association of Protein Kinase Ctheta with a Lipid Raft-Associated Inhibitor of kB Factor Kinase (IKK) Complex Plays a Role in the Activation of the NF-kB Cascade by TCR and CD28." [PubMed:11120819]
exact_synonym: "Activation of NF-kappaB by PKC" []
exact_synonym: "NF-kappaB activation" [PubMed:14632637]
xref_analog: IMR:0000243
xref_analog: IMR:0100484
xref_analog: PubMed:11120819
xref_analog: PubMed:11973130
is_a: IEV:0002317 ! Activation of IKK complex by PKCs in cytosol

[Term]
id: IEV:0000292
name: Medication
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0000293
name: Medium condition
is_a: IEV:0000185 ! Environmental event

[Term]
id: IEV:0000294
name: Plant hormone medication
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0000295
name: KBM (medium)
is_a: IEV:0000316 ! Epidermal keratinocyto medium

[Term]
id: IEV:0000296
name: KBM-2 (medium)
is_a: IEV:0000316 ! Epidermal keratinocyto medium

[Term]
id: IEV:0000297
name: MEGM (medium)
is_a: IEV:0000353 ! Mammary epithelial cell medium

[Term]
id: IEV:0000298
name: MEBM (medium)
is_a: IEV:0000353 ! Mammary epithelial cell medium

[Term]
id: IEV:0000299
name: BEBM (medium)
is_a: IEV:0000352 ! Human bronchial epithelial cell medium

[Term]
id: IEV:0000300
name: SABM (medium)
is_a: IEV:0000352 ! Human bronchial epithelial cell medium

[Term]
id: IEV:0000301
name: PrEGM (medium)
is_a: IEV:0000354 ! Human prostate epithelial cell medium

[Term]
id: IEV:0000302
name: PrEBM (medium)
is_a: IEV:0000354 ! Human prostate epithelial cell medium

[Term]
id: IEV:0000304
name: DMEM (medium)
is_a: IEV:0000311 ! ES cell medium

[Term]
id: IEV:0000305
name: 199 medium
is_a: IEV:0000341 ! Chicken aortic smooth muscle cell medium
is_a: IEV:0000342 ! Fibroblast medium

[Term]
id: IEV:0000306
name: Animal cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000307
name: KGM-2 (medium)
is_a: IEV:0000316 ! Epidermal keratinocyto medium

[Term]
id: IEV:0000308
name: Rat cell medium
is_a: IEV:0000306 ! Animal cell medium

[Term]
id: IEV:0000309
name: Mouse cell medium
is_a: IEV:0000306 ! Animal cell medium

[Term]
id: IEV:0000310
name: Neuronal cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000311
name: ES cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000312
name: HeLa medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000313
name: BME medium
is_a: IEV:0000312 ! HeLa medium
is_a: IEV:0000314 ! Mouse L-cell medium

[Term]
id: IEV:0000314
name: Mouse L-cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000315
name: Hepatocyte medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000316
name: Epidermal keratinocyto medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000317
name: Macrophage medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000318
name: Amniocyte medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000319
name: Peripheral blood medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000320
name: Bone marrow medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000321
name: Human hematopoietic cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000322
name: Lymphocyte medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000323
name: CHO medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000324
name: DG44 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000325
name: 293 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000326
name: COS-7 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000327
name: MDCK medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000328
name: VERO medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000329
name: BHK-21 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000330
name: PK-15 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000331
name: CV-1 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000332
name: WI-38 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000333
name: Hybridoma cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000334
name: HEp2 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000335
name: A549 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000336
name: BSC-1 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000337
name: Ham's F-10 medium
is_a: IEV:0000323 ! CHO medium
is_a: IEV:0000333 ! Hybridoma cell medium
is_a: IEV:0000338 ! Myeloma medium

[Term]
id: IEV:0000338
name: Myeloma medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000339
name: Ham's F-12 medium
is_a: IEV:0000323 ! CHO medium
is_a: IEV:0000333 ! Hybridoma cell medium
is_a: IEV:0000338 ! Myeloma medium

[Term]
id: IEV:0000340
name: IMDM (medium)
is_a: IEV:0000322 ! Lymphocyte medium
is_a: IEV:0000333 ! Hybridoma cell medium

[Term]
id: IEV:0000341
name: Chicken aortic smooth muscle cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000342
name: Fibroblast medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000343
name: All-purpose medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000344
name: MEM (medium)
is_a: IEV:0000343 ! All-purpose medium

[Term]
id: IEV:0000346
name: Alpha MEM (medium)
is_a: IEV:0000333 ! Hybridoma cell medium

[Term]
id: IEV:0000348
name: Jurkat cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000349
name: HL60 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000350
name: Waymouth's medium
is_a: IEV:0000314 ! Mouse L-cell medium

[Term]
id: IEV:0000351
name: Mesenchymal cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000352
name: Human bronchial epithelial cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000353
name: Mammary epithelial cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000354
name: Human prostate epithelial cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000355
name: SAGM (medium)
is_a: IEV:0000352 ! Human bronchial epithelial cell medium

[Term]
id: IEV:0000356
name: BEGM (medium)
is_a: IEV:0000352 ! Human bronchial epithelial cell medium

[Term]
id: IEV:0000357
name: KGM (medium)
is_a: IEV:0000316 ! Epidermal keratinocyto medium

[Term]
id: IEV:0000362
name: Human vascular smooth muscle medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000363
name: Human vascular endothelial cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000365
name: Cambium dormancy
is_a: IEV:0000072 ! Dormancy

[Term]
id: IEV:0000366
name: Cell cycle process
def: "A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GO:0022402]
xref_analog: GO:0022402
xref_analog: KEGG:hsa04110
is_a: IEV:0000069 ! Cellular event
is_a: IEV:0001842 ! Signaling pathway
relationship: part_of IEV:0000077 ! Cell cycle

[Term]
id: IEV:0000368
name: G2-M-phase transition
def: "Progression from G2 phase to M phase of the mitotic cell cycle." [GO:0000086]
xref_analog: GO:0000086
xref_analog: KEGG:hsa04110
is_a: IEV:0000366 ! Cell cycle process

[Term]
id: IEV:0000369
name: Binding of Cdk4 and cyclin D in cytosol
xref_analog: IMR:0100600
xref_analog: IMR:0100614
is_a: IEV:0001071 ! Binding of Cdk4/6 and cyclin D in cytosol

[Term]
id: IEV:0000370
name: Phosphorylation of Cdk4/6 by CAK in cytosol
xref_analog: IMR:0100600
xref_analog: IMR:0100602
xref_analog: IMR:0100636
xref_analog: REACT:96.4
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001106 ! G1 phase

[Term]
id: IEV:0000371
name: Temperature treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0000372
name: Radiation treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0000373
name: Wavelength of light treatment
is_a: IEV:0000372 ! Radiation treatment

[Term]
id: IEV:0000374
name: Photoperiod treatment
is_a: IEV:0000372 ! Radiation treatment

[Term]
id: IEV:0000375
name: Freeze treatment
is_a: IEV:0000378 ! Low temperature treatment

[Term]
id: IEV:0000376
name: Cold temperature treatment
is_a: IEV:0000378 ! Low temperature treatment

[Term]
id: IEV:0000377
name: High temperature treatment
is_a: IEV:0000371 ! Temperature treatment

[Term]
id: IEV:0000378
name: Low temperature treatment
is_a: IEV:0000371 ! Temperature treatment

[Term]
id: IEV:0000379
name: Heat treatment
is_a: IEV:0000371 ! Temperature treatment

[Term]
id: IEV:0000380
name: Physical stimulus treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0000381
name: Gravity treatment
is_a: IEV:0000380 ! Physical stimulus treatment

[Term]
id: IEV:0000382
name: Oxidation
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0000383
name: Contact pressure treatment
is_a: IEV:0000380 ! Physical stimulus treatment

[Term]
id: IEV:0000384
name: Magnetic force treatment
is_a: IEV:0000380 ! Physical stimulus treatment

[Term]
id: IEV:0000385
name: Electricity treatment
is_a: IEV:0000380 ! Physical stimulus treatment

[Term]
id: IEV:0000386
name: FK506 medication
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0000387
name: Treatment
is_a: IEV:0000185 ! Environmental event

[Term]
id: IEV:0000388
name: Nuclear import of Cdk4:cyclin D
xref_analog: IMR:0100600
xref_analog: IMR:0100614
is_a: IEV:0001072 ! Nuclear import of Cdk4/6_p:cyclin D

[Term]
id: IEV:0000389
name: Phosphorylation of RB by Cdk4_p in inner space of nucleus
xref_analog: IMR:0000461
xref_analog: IMR:0100600
is_a: IEV:0001074 ! Phosphorylation of RB by Cdk4/6 in inner space of nucleus

[Term]
id: IEV:0000390
name: Dissociation of E2F and RB_p in inner space of nucleus
xref_analog: IMR:0000461
xref_analog: IMR:0000848
xref_analog: REACT:1882.4
is_a: IEV:0001046 ! Dissociation in inner space of nucleus
relationship: part_of IEV:0001095 ! S phase
relationship: part_of IEV:0001106 ! G1 phase

[Term]
id: IEV:0000391
name: Negative regulation of G1-S-phase transition
is_a: IEV:0000546 ! Regulation of G1-S-phase transition
is_a: IEV:0001404 ! Negative regulation of cell cycle process
relationship: negatively_regulates IEV:0001070 ! G1-S-phase transition

[Term]
id: IEV:0000392
name: Ubiquitination of Cyclin D in cytosol
xref_analog: IMR:0100614
xref_analog: REACT:715.2
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0001084 ! Cyclin D degradation signaling

[Term]
id: IEV:0000393
name: DNA replication
def: "The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA." [GO:0006260]
xref_analog: GO:0006260
xref_analog: MeSH:D004261
xref_analog: REACT:383.2
is_a: IEV:0000071 ! Molecular event

[Term]
id: IEV:0000394
name: CoA ligation
xref_analog: EC:6.2.1
is_a: IEV:0000912 ! Ligation

[Term]
id: IEV:0000396
name: Lignin biosynthesis
def: "The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers." [GO:0009809]
exact_synonym: "lignin anabolism" []
exact_synonym: "lignin biosynthetic process" []
exact_synonym: "lignin formation" []
exact_synonym: "lignin synthesis" []
xref_analog: GO:0009809
is_a: IEV:0001557 ! Amino acid derivative metabolism
relationship: part_of IEV:0002216 ! Cell wall organization and biosynthesis

[Term]
id: IEV:0000397
name: Embryonic development
def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GO:0009790]
exact_synonym: "embryogenesis" []
exact_synonym: "embryonal development" []
xref_analog: GO:0009790
is_a: IEV:0000083 ! Development
relationship: part_of IEV:0003745 ! Multicellular organismal development

[Term]
id: IEV:0000398
name: Post embryonic development
def: "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GO:0009791]
xref_analog: GO:0009791
is_a: IEV:0000083 ! Development
relationship: part_of IEV:0003745 ! Multicellular organismal development

[Term]
id: IEV:0000400
name: Binding of c-AMP and PKA regulatory subunits and active conformational change in cytosol
alt_id: IEV:0000781
exact_synonym: "Dissociation of PKA catalytic subunit and regulatory subunit" []
xref_analog: IMR:0100024
xref_analog: IMR:0100702
xref_analog: PubMed:15023366
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000780 ! PKA activation signaling

[Term]
id: IEV:0000401
name: Phosphorylation of Bad by PKA in cytosol
xref_analog: IMR:0000249
xref_analog: IMR:0100288
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000055 ! PKA-Bad signaling

[Term]
id: IEV:0000402
name: Phosphorylation of caspase9 by AKT in cytosol
xref_analog: IMR:0000250
xref_analog: IMR:0100299
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)
relationship: part_of IEV:0001707 ! AKT(PKB)-caspase signaling

[Term]
id: IEV:0000403
name: Phosphorylation of Bad by AKT_p
exact_synonym: "Akt1 phosphorylates BAD protein" []
xref_analog: IMR:0000250
xref_analog: IMR:0100288
xref_analog: REACT:188.2
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0000624 ! Phosphorylation outside the mitochondria membrane
relationship: part_of IEV:0000166 ! AKT(PKB)-Bad signaling

[Term]
id: IEV:0000404
name: Binding of Bad_p and 14-3-3 in cytosol
exact_synonym: "Sequesteration of BAD protein by 14-3-3" []
xref_analog: IMR:0000456
xref_analog: IMR:0100288
xref_analog: REACT:1139.2
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000055 ! PKA-Bad signaling
relationship: part_of IEV:0000056 ! RSK-Bad signaling
relationship: part_of IEV:0000166 ! AKT(PKB)-Bad signaling

[Term]
id: IEV:0000405
name: Translocation of Bad_p from mitochondria membrane to cytosol
xref_analog: IMR:0100288
is_a: IEV:0000175 ! Translocation from mitochondria membrane to cytosol
relationship: part_of IEV:0000055 ! PKA-Bad signaling
relationship: part_of IEV:0000056 ! RSK-Bad signaling
relationship: part_of IEV:0000166 ! AKT(PKB)-Bad signaling

[Term]
id: IEV:0000406
name: Bad activation signaling
exact_synonym: "Activation of BAD and translocation to mitochondria" []
exact_synonym: "Bad dephosphorylation signaling" []
xref_analog: GO:0008633
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
xref_analog: REACT:549.2
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0001667 ! Bcl-2/Bcl-xL inactivation signaling

[Term]
id: IEV:0000407
name: Oxidation of ferulate in cytosol
xref_analog: KEGG:C01494
is_a: IEV:0000171 ! Oxidation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000408
name: Phosphorylation of AKT by PDK1
xref_analog: IMR:0000250
xref_analog: IMR:0000255
is_a: IEV:0000624 ! Phosphorylation outside the mitochondria membrane
is_a: IEV:0002415 ! Phosphorylation of Akt by protein kinase in cytosol

[Term]
id: IEV:0000409
name: Removement of survival factor
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0000411
name: Translocation of Bad from the cytosol to the mitochondria membrane
exact_synonym: "Translocation of activated BAD protein to mitochondria" []
xref_analog: GO:0001844
xref_analog: IMR:0100288
xref_analog: REACT:2046.3
is_a: IEV:0000412 ! Translocation from cytosol to mitochondria membrane
relationship: part_of IEV:0001667 ! Bcl-2/Bcl-xL inactivation signaling

[Term]
id: IEV:0000412
name: Translocation from cytosol to mitochondria membrane
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000413
name: Dephosphorylation of Bad_p by calcineurin in cytosol
exact_synonym: "Activation of BAD by calcineurin" []
xref_analog: IMR:0000278
xref_analog: IMR:0100288
xref_analog: REACT:1663.2
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0000406 ! Bad activation signaling

[Term]
id: IEV:0000414
name: Dephosphorylation in plasma membrane
is_a: IEV:0000011 ! Dephosphorylation

[Term]
id: IEV:0000415
name: Oxidation of 4-coumarate in cytosol
xref_analog: KEGG:C00811
is_a: IEV:0000171 ! Oxidation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000416
name: Peroxidation of 4-Coumaryl alcohol to Lignin (grasses) in cytosol
xref_analog: KEGG:C02646
xref_analog: KEGG:C05615
is_a: IEV:0000171 ! Oxidation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000417
name: Translocation of Coniferyl alcohol to cell wall
xref_analog: KEGG:C00590
is_a: IEV:0000429 ! Translocation from cytosol to cell wall
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000418
name: Translocation of 4-Coumaryl alcohol to cell wall
xref_analog: KEGG:C02646
is_a: IEV:0000429 ! Translocation from cytosol to cell wall
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000419
name: O-methyltransferase of caffeoyl-CoA by CCR in cytosol
xref_analog: EC:2.1.1.104
xref_analog: KEGG:C00323
xref_analog: KEGG:R01942
is_a: IEV:0000435 ! Transmethylation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000420
name: Hydroxylation of trans-cinnamate by C4H in the cytosol
xref_analog: KEGG:C00423
is_a: IEV:0000438 ! Hydroxylation in the cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000421
name: Peroxidation of sinapyl alcohol to Lignin (angiosperm and grasses) in cytosol
xref_analog: KEGG:C02325
xref_analog: KEGG:C05615
is_a: IEV:0000171 ! Oxidation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000422
name: CoA ligation of caffeic acid by 4CL in cytosol
xref_analog: EC:6.2.1.12
xref_analog: IMR:0200354
xref_analog: KEGG:C00223
xref_analog: KEGG:C01197
xref_analog: KEGG:R01943
is_a: IEV:0000430 ! CoA ligation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000423
name: CoA ligation of 4-coumarate by 4CL in cytosol
xref_analog: EC:6.2.1.12
xref_analog: IMR:0200354
xref_analog: KEGG:C00223
xref_analog: KEGG:C00811
xref_analog: KEGG:R01616
is_a: IEV:0000430 ! CoA ligation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000424
name: CoA ligation of ferulate by 4CL in cytosol
xref_analog: EC:6.2.1.12
xref_analog: IMR:0200354
xref_analog: KEGG:C00223
xref_analog: KEGG:C01494
xref_analog: KEGG:R02194
is_a: IEV:0000430 ! CoA ligation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000425
name: O-methyl-transfer of caffeic acid by OMT in cytosol
xref_analog: EC:2.1.1.68
xref_analog: KEGG:C01197
xref_analog: KEGG:R03366
is_a: IEV:0000435 ! Transmethylation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000426
name: CoA ligation of 5-Hydroxyferulate by 4CL in cytosol
xref_analog: EC:6.2.1.12
xref_analog: IMR:0200354
xref_analog: KEGG:C00223
xref_analog: KEGG:C05619
xref_analog: KEGG:R06583
is_a: IEV:0000430 ! CoA ligation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000427
name: Peroxidation of coniferyl alcohol to Lignin (gymnosperm, angiosperm and grasses) in cytosol
xref_analog: KEGG:C00590
xref_analog: KEGG:C05615
is_a: IEV:0000171 ! Oxidation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000428
name: Translocation of sinapyl alcohol to cell wall
xref_analog: KEGG:C02325
is_a: IEV:0000429 ! Translocation from cytosol to cell wall
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000429
name: Translocation from cytosol to cell wall
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000430
name: CoA ligation in cytosol
is_a: IEV:0000394 ! CoA ligation

[Term]
id: IEV:0000431
name: CoA ligation inside of the plasma membrane
is_a: IEV:0000430 ! CoA ligation in cytosol

[Term]
id: IEV:0000432
name: CoA ligation in unidentified cellular location
is_a: IEV:0000394 ! CoA ligation

[Term]
id: IEV:0000433
name: Transmethylation
def: "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer. Irreversible reaction that can affect A,G,M,F,P,C,R,N,Q,E,H,or K residues." [MI:0213]
xref_analog: EC:2.1.1.-
xref_analog: MI:0213
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0000434
name: Transmethylation in unidentified cellular location
is_a: IEV:0000433 ! Transmethylation

[Term]
id: IEV:0000435
name: Transmethylation in cytosol
is_a: IEV:0000433 ! Transmethylation

[Term]
id: IEV:0000436
name: Isoprenylation in cytosol
is_a: IEV:0000921 ! Isoprenylation

[Term]
id: IEV:0000437
name: Hydroxylation
def: "Irreversible reaction that can affect K,P,Y or R residues." [MI:0210]
xref_analog: MI:0210
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0000438
name: Hydroxylation in the cytosol
is_a: IEV:0000437 ! Hydroxylation

[Term]
id: IEV:0000439
name: Hydroxylation in the unidentified cellular location
is_a: IEV:0000437 ! Hydroxylation

[Term]
id: IEV:0000440
name: Farnesylation in cytosol
is_a: IEV:0000919 ! Farnesylation

[Term]
id: IEV:0000441
name: Lignin biosynthesis (angiosperm)
is_a: IEV:0000396 ! Lignin biosynthesis

[Term]
id: IEV:0000442
name: Lignin biosynthesis (gymnosperm)
is_a: IEV:0000396 ! Lignin biosynthesis

[Term]
id: IEV:0000443
name: Lignin biosynthesis (grasses)
is_a: IEV:0000396 ! Lignin biosynthesis

[Term]
id: IEV:0000444
name: Translocation of Bax from the cytosol to the mitochondria membrane
exact_synonym: "Translocation of activated BAX to the mitochondria" []
xref_analog: GO:0001844
xref_analog: IMR:0000453
xref_analog: REACT:1286.3
is_a: IEV:0000412 ! Translocation from cytosol to mitochondria membrane
relationship: part_of IEV:0000167 ! Bax activation signaling

[Term]
id: IEV:0000445
name: MAPKKK cascade
def: "Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways." [GO:0000165]
exact_synonym: "MAP kinase cascade" [GO:0000165]
exact_synonym: "MAP kinase kinase kinase cascade" [GO:0000165]
exact_synonym: "MAPK cascade" []
xref_analog: GO:0000165
xref_analog: KEGG:hsa04010
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0000446
name: Phosphorylation of STAT by JAK_p in cytosol
xref_analog: GO:0007260
xref_analog: IMR:0000213
xref_analog: IMR:0000374
xref_analog: PubMed:12039028
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000447
name: Anatomical structure morphogenesis
def: "The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GO:0009653]
exact_synonym: "anatomical structure organization" [GO:0009653]
exact_synonym: "morphogenesis" [GO:0009653]
xref_analog: GO:0009653
is_a: IEV:0000083 ! Development
relationship: part_of IEV:0003795 ! Anatomical structure development

[Term]
id: IEV:0000448
name: Hematopoiesis
def: "The process of blood cell formation. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GO:0030097]
exact_synonym: "blood cell biosynthesis" []
exact_synonym: "blood cell formation" []
exact_synonym: "Haemopoiesis" []
exact_synonym: "Hemopoiesis" []
xref_analog: GO:0030097
is_a: IEV:0002712 ! Organ development

[Term]
id: IEV:0000449
name: Negative regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
def: "OBSOLETE: remap to 'Negative regulation of Ras-Raf-MAPK signaling by spred' IEV:0003544." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0000452
name: Insulin receptor signaling pathway (through IRS mediated signaling)
exact_synonym: "Insulin receptor signaling pathway (through AKT-Bad signaling)" []
is_a: IEV:0000487 ! Insulin receptor signaling pathway
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000453
name: Phosphorylation of p53 by ATM in inner space of nucleus
xref_analog: IMR:0100659
xref_analog: UniProt:Q13315
is_a: IEV:0001082 ! Phosphorylation in inner space of nucleus
relationship: part_of IEV:0000165 ! p53 signaling pathway (through p21)
relationship: part_of IEV:0001107 ! p53 signaling pathway (through GADD45)
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0000454
name: IGF signaling pathway
def: "The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands." [GO:0048009]
exact_synonym: "IGF receptor signaling pathway" [GO:0048009]
exact_synonym: "insulin-like growth factor receptor signaling pathway" [GO:0048009]
xref_analog: GO:0048009
xref_analog: PubMed:15205477
is_a: IEV:0001690 ! Negative regulation of caloric restriction - cell survival signaling
is_a: IEV:0003684 ! Insulin receptor family signaling pathway

[Term]
id: IEV:0000455
name: TNFR1 signaling pathway (through JNK cascade)
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0002408 ! TNFR1 signaling pathway

[Term]
id: IEV:0000456
name: Binding of TRAF2 and ASK1 in cytosol
xref_analog: IMR:0100218
xref_analog: IMR:0100423
is_a: IEV:0001725 ! Binding of TRAF2 and MAPKKK in cytosol
relationship: part_of IEV:0000455 ! TNFR1 signaling pathway (through JNK cascade)

[Term]
id: IEV:0000457
name: Binding of TRADD and FADD in cytosol
exact_synonym: "TRADD:TRAF2:RIP1 complex binds FADD" []
xref_analog: IMR:0100463
xref_analog: IMR:0100464
xref_analog: REACT:1766.1
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000114 ! TNFR1 signaling pathway (through caspase cascade)

[Term]
id: IEV:0000458
name: Protein activation/inactivation signaling
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0000459
name: Autophosphorylation in unidentified cellular location
is_a: IEV:0000490 ! Autophosphorylation

[Term]
id: IEV:0000460
name: T cell receptor signaling pathway
def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell." [GO:0050852]
exact_synonym: "T lymphocyte receptor signaling pathway" [GO:0050852]
exact_synonym: "T-cell receptor signaling pathway" [GO:0050852]
exact_synonym: "T-lymphocyte receptor signaling pathway" [GO:0050852]
xref_analog: GO:0050852
xref_analog: KEGG:hsa04660
is_a: IEV:0001842 ! Signaling pathway
relationship: part_of IEV:0000098 ! Immune response

[Term]
id: IEV:0000461
name: Regulation of p53 signaling pathway
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0001103 ! p53 signaling pathway

[Term]
id: IEV:0000462
name: Toll-like receptor signaling pathway
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GO:0002224]
comment: Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses.
exact_synonym: "TLR signaling pathway" [GO:0002224]
xref_analog: GO:0002224
xref_analog: KEGG:hsa04620
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0000463
name: Negative regulation of p53 signaling pathway
is_a: IEV:0000461 ! Regulation of p53 signaling pathway
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0001103 ! p53 signaling pathway

[Term]
id: IEV:0000464
name: Positive regulation of p53 signaling pathway
is_a: IEV:0000461 ! Regulation of p53 signaling pathway
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0001103 ! p53 signaling pathway

[Term]
id: IEV:0000465
name: TNFR signaling pathway
exact_synonym: "Death Receptor Signalling" []
exact_synonym: "Extrinsic Pathway for Apoptosis" []
exact_synonym: "induction of apoptosis by extracellular signals" []
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0000466
name: Nuclear import of ERK_p
xref_analog: IMR:0000227
is_a: IEV:0000480 ! Nuclear import of MAPK (through MAPKKK cascade)
relationship: part_of IEV:0000115 ! ERK cascade

[Term]
id: IEV:0000467
name: PLC gamma signaling
alt_id: IEV:0000058
alt_id: IEV:0000271
alt_id: IEV:0000468
comment: T cell=PLC gamma1, B cell=gamma2, PDGFR=PLC gamma1
exact_synonym: "PLC gamma signaling (through BLNK)" []
exact_synonym: "PLC gamma signaling (through LAT)" []
exact_synonym: "PLC gamma signaling (through RTK)" []
xref_analog: PubMed:10579907
is_a: IEV:0000471 ! PLC signaling
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
relationship: part_of IEV:0000482 ! CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000469
name: Binding of PLC gamma and PIP3 in cytosol
def: "activation of PLC gamma, PLC gamma_SH2 or PH domain" [XX:<new dbxref>]
xref_analog: IMR:0000285
xref_analog: IMR:0001352
is_a: IEV:0000284 ! Binding of PLC and PIP3 in cytosol
relationship: part_of IEV:0000467 ! PLC gamma signaling

[Term]
id: IEV:0000470
name: Binding of PLC beta and PIP3 in cytosol
xref_analog: IMR:0000286
xref_analog: IMR:0001352
is_a: IEV:0000284 ! Binding of PLC and PIP3 in cytosol

[Term]
id: IEV:0000471
name: PLC signaling
exact_synonym: "phospholipase C signaling" []
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0000472
name: Hydrolysis of PIP2 by PLC to generate DAG and IP3 in cytosol
xref_analog: IMR:0000284
xref_analog: IMR:0001350
xref_analog: IMR:0100027
xref_analog: IMR:0100028
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000471 ! PLC signaling

[Term]
id: IEV:0000473
name: Hydrolysis of PIP2 by PLC beta to generate DAG and IP3 in cytosol
xref_analog: IMR:0000286
xref_analog: IMR:0001350
xref_analog: IMR:0100027
xref_analog: IMR:0100028
is_a: IEV:0000472 ! Hydrolysis of PIP2 by PLC to generate DAG and IP3 in cytosol
relationship: part_of IEV:0000065 ! PLC beta signaling

[Term]
id: IEV:0000474
name: Phosphorylation of MAPKK by MAPKKK in cytosol
alt_id: IEV:0002094
def: "The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK." [GO:0000186]
exact_synonym: "activation of MAPKK activity" [GO:0000186]
exact_synonym: "Phosphorylation of MKK by MAPKKK" []
xref_analog: GO:0000186
xref_analog: IMR:0000229
xref_analog: IMR:0000259
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000445 ! MAPKKK cascade

[Term]
id: IEV:0000475
name: Phosphorylation of MEK1/2(MKK1/2) by MAPKKK in cytosol
xref_analog: IMR:0000229
xref_analog: IMR:0000261
is_a: IEV:0000474 ! Phosphorylation of MAPKK by MAPKKK in cytosol
relationship: part_of IEV:0000115 ! ERK cascade

[Term]
id: IEV:0000476
name: Phosphorylation of ERK by MEK1/2(MKK1/2)_p in cytosol
xref_analog: IMR:0000227
xref_analog: IMR:0000261
xref_analog: PubMed:14734786
is_a: IEV:0002067 ! Phosphorylation of MAPK by MEK in cytosol
relationship: part_of IEV:0000115 ! ERK cascade

[Term]
id: IEV:0000477
name: Phosphorylation of transcriptional regulator by ERK_p in inner space of nucleus
xref_analog: IMR:0000227
xref_analog: IMR:0000369
is_a: IEV:0000479 ! Phosphorylation of transcriptional regulator by MAPK_p in inner space of nucleus
relationship: part_of IEV:0000115 ! ERK cascade

[Term]
id: IEV:0000478
name: Phosphorylation of MAPK by MAPKK in cytosol
def: "The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK." [GO:0000187]
exact_synonym: "activation of MAP kinase" []
exact_synonym: "activation of MAPK activity" []
xref_analog: GO:0000187
xref_analog: IMR:0000224
xref_analog: IMR:0000259
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000445 ! MAPKKK cascade

[Term]
id: IEV:0000479
name: Phosphorylation of transcriptional regulator by MAPK_p in inner space of nucleus
def: "Dually phosphorylated MAPK, or dpERK, phosphorylates protein targets in both the cytoplasm and nucleus." [PubMed:16771628]
xref_analog: IMR:0000224
xref_analog: IMR:0000369
is_a: IEV:0001082 ! Phosphorylation in inner space of nucleus
relationship: part_of IEV:0000445 ! MAPKKK cascade

[Term]
id: IEV:0000480
name: Nuclear import of MAPK (through MAPKKK cascade)
def: "The directed movement of a MAP kinase to the nucleus upon activation." [GO:0000189]
exact_synonym: "nuclear translocation of MAPK" []
xref_analog: GO:0000189
xref_analog: IMR:0000224
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000445 ! MAPKKK cascade

[Term]
id: IEV:0000481
name: Autophosphorylation in cytosol
is_a: IEV:0000490 ! Autophosphorylation

[Term]
id: IEV:0000482
name: CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
exact_synonym: "CD4 T cell receptor signaling pathway (through PLC gamma, calcineurin and NF-AT)" []
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000460 ! T cell receptor signaling pathway

[Term]
id: IEV:0000483
name: Binding of calcium ion and PKC and active conformational change of PKC in cytosol
xref_analog: IMR:0000245
xref_analog: IMR:0100031
xref_analog: PubMed:7499357
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000779 ! PKC activation signaling

[Term]
id: IEV:0000484
name: Binding of DAG, calcium ion and PKC and active conformational change of PKC in cytosol
xref_analog: IMR:0000245
xref_analog: IMR:0100027
xref_analog: IMR:0100031
xref_analog: PubMed:7499357
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000779 ! PKC activation signaling

[Term]
id: IEV:0000485
name: Transcription of IL-2 in nucleus
xref_analog: IMR:0000008
xref_analog: PubMed:11973130
is_a: IEV:0003549 ! Transcription in nucleus
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000486
name: Autophosphorylation in plasma membrane
is_a: IEV:0000490 ! Autophosphorylation

[Term]
id: IEV:0000487
name: Insulin receptor signaling pathway
def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GO:0008286]
exact_synonym: "Insulin receptor mediated signalling" []
xref_analog: GO:0008286
xref_analog: REACT:498.5
is_a: IEV:0003684 ! Insulin receptor family signaling pathway

[Term]
id: IEV:0000488
name: Binding of insulin and insulin receptor in extracellular
exact_synonym: "Insulin binding" []
xref_analog: IMR:0000052
xref_analog: IMR:0000078
xref_analog: REACT:1459.4
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000489
name: Autophosphorylation of insulin receptor in plasma membrane
xref_analog: IMR:0000078
xref_analog: REACT:2211.3
is_a: IEV:0000486 ! Autophosphorylation in plasma membrane
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000490
name: Autophosphorylation
xref_analog: GO:0046777
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0000491
name: Binding of insulin receptor and Shc in cytosol
exact_synonym: "Binding of SHC to insulin receptor" []
xref_analog: IMR:0000078
xref_analog: IMR:0000347
xref_analog: REACT:106.2
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000126 ! Insulin receptor signaling pathway (through Shc mediated signaling)

[Term]
id: IEV:0000492
name: Phosphorylation of Shc by insulin receptor in cytosol
exact_synonym: "Phosphorylation of SHC" []
xref_analog: IMR:0000078
xref_analog: IMR:0000347
xref_analog: REACT:2015.2
is_a: IEV:0002631 ! Phosphorylation of Shc by RTK in cytosol
relationship: part_of IEV:0000126 ! Insulin receptor signaling pathway (through Shc mediated signaling)

[Term]
id: IEV:0000493
name: Dissociation of Shc and insulin receptor in cytosol
exact_synonym: "Dissociation of SHC-P from insulin receptor" []
xref_analog: IMR:0000078
xref_analog: IMR:0000347
xref_analog: REACT:596.2
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000126 ! Insulin receptor signaling pathway (through Shc mediated signaling)

[Term]
id: IEV:0000494
name: Binding of IRS and insulin receptor in cytosol
exact_synonym: "Binding of IRS to insulin receptor" []
xref_analog: IMR:0000078
xref_analog: IMR:0000351
xref_analog: REACT:2120.3
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000452 ! Insulin receptor signaling pathway (through IRS mediated signaling)

[Term]
id: IEV:0000495
name: Phosphorylation of IRS by insulin receptor in cytosol
exact_synonym: "Phosphorylation of IRS" []
xref_analog: IMR:0000078
xref_analog: IMR:0000351
xref_analog: REACT:342.3
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000452 ! Insulin receptor signaling pathway (through IRS mediated signaling)

[Term]
id: IEV:0000496
name: Dissociation of IRS and insulin receptor in cytosol
exact_synonym: "Dissociation of IRS-P from insulin receptor" []
xref_analog: IMR:0000078
xref_analog: IMR:0000351
xref_analog: REACT:562.2
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000452 ! Insulin receptor signaling pathway (through IRS mediated signaling)

[Term]
id: IEV:0000497
name: Internalisation of the insulin receptor
xref_analog: IMR:0000078
xref_analog: REACT:599.2
is_a: IEV:0000508 ! Translocation from plasma membrane to cytosol
is_a: IEV:0001505 ! Receptor internalization
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000498
name: Insulin receptor recycling
xref_analog: REACT:1109.2
is_a: IEV:0001255 ! Receptor recycling
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000499
name: Influx of hydrogen ion into the lumen of the endosome by proton pump
exact_synonym: "Endosome acidification" []
xref_analog: IMR:0001051
xref_analog: IMR:0200030
xref_analog: REACT:2002.3
is_a: IEV:0000504 ! Translocation from cytosol into lumen of endosome
relationship: part_of IEV:0000498 ! Insulin receptor recycling

[Term]
id: IEV:0000500
name: Dissociation of insulin and insulin receptor in extracellular
exact_synonym: "Dissociation of insulin from insulin receptor" []
xref_analog: IMR:0000052
xref_analog: IMR:0000078
xref_analog: REACT:134.2
is_a: IEV:0000506 ! Dissociation in extracellular
relationship: part_of IEV:0000498 ! Insulin receptor recycling

[Term]
id: IEV:0000501
name: Negative regulation of insulin signaling pathway
def: "Any process that stops, prevents or reduces the frequency, rate or extent of insulin receptor signaling." [GO:0046627]
xref_analog: GO:0046627
is_a: IEV:0000548 ! Regulation of insulin receptor signaling pathway
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000502
name: Dephosphorylation of Insulin receptor by PTP in cytosol
exact_synonym: "Insulin receptor de-phosphorylation" []
xref_analog: IMR:0000078
xref_analog: IMR:0000273
xref_analog: REACT:453.3
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0000498 ! Insulin receptor recycling
relationship: part_of IEV:0000501 ! Negative regulation of insulin signaling pathway

[Term]
id: IEV:0000503
name: Translocation of insulin receptor from the endosome to plasma membrane
exact_synonym: "Re-integration of insulin receptor into plasma membrane" []
xref_analog: IMR:0000078
xref_analog: REACT:490.2
is_a: IEV:0000505 ! Translocation from endosome to plasma membrane
relationship: part_of IEV:0000498 ! Insulin receptor recycling

[Term]
id: IEV:0000504
name: Translocation from cytosol into lumen of endosome
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000505
name: Translocation from endosome to plasma membrane
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000506
name: Dissociation in extracellular
is_a: IEV:0000006 ! Dissociation

[Term]
id: IEV:0000507
name: Dissociation in unidentified cellular location
is_a: IEV:0000006 ! Dissociation

[Term]
id: IEV:0000508
name: Translocation from plasma membrane to cytosol
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000509
name: Dephosphorylation of Lck_p by CD45 and active conformational change
exact_synonym: "Dephosphorylation of Lck_p (phosphorylated in the C-terminal phosphorylation site) by CD45 and active conformational change" []
xref_analog: IMR:0001045
xref_analog: IMR:0100353
xref_analog: PubMed:11781344
xref_analog: PubMed:12040176
is_a: IEV:0001599 ! Dephosphorylation of Lck_p by PTP and active conformational change in cytosol

[Term]
id: IEV:0000510
name: Autophosphorylation of Lck and active conformational change in cytosol
xref_analog: IMR:0100353
xref_analog: PubMed:11781344
xref_analog: PubMed:15034556
is_a: IEV:0001607 ! Autophosphorylation of Src family and active conformational change in cytosol
relationship: part_of IEV:0000519 ! Lck activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0000511
name: Binding of CD4 and Lck in extracellular
xref_analog: IMR:0100294
xref_analog: IMR:0100353
xref_analog: PubMed:15343367
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0001479 ! CD28 signaling

[Term]
id: IEV:0000512
name: Negative regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
exact_synonym: "Negative regulation of CD4 T cell receptor signaling pathway (through PLC gamma, PKC and IKK-NF-kappaB cascade)" []
is_a: IEV:0000542 ! Regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0001375 ! Negative regulation of T cell receptor signaling pathway
relationship: negatively_regulates IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000513
name: Lck inactivation signaling (through PTP)
xref_analog: IMR:0000273
xref_analog: PubMed:11781344
xref_analog: PubMed:12040176
xref_analog: PubMed:15034556
is_a: IEV:0001620 ! Negative regulation of Src activation signaling
is_a: IEV:0001635 ! Lck inactivation signaling
is_a: IEV:0001894 ! Negative regulation of (phosphorylation of Lck) Lck activation signaling (autophosphorylation and PTP)
is_a: IEV:0002255 ! Negative regulation of (Lck activation signaling)

[Term]
id: IEV:0000514
name: Phosphorylation of PAG/Cbp by Fyn in cytosol
xref_analog: IMR:0100346
xref_analog: IMR:0100352
xref_analog: PubMed:11781344
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000513 ! Lck inactivation signaling (through PTP)
relationship: part_of IEV:0001890 ! Lck inactivation signaling (through Csk)

[Term]
id: IEV:0000515
name: Binding of PAG/Cbp_p and Csk in cytosol
xref_analog: IMR:0000212
xref_analog: IMR:0100346
xref_analog: PubMed:11781344
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000513 ! Lck inactivation signaling (through PTP)
relationship: part_of IEV:0001890 ! Lck inactivation signaling (through Csk)

[Term]
id: IEV:0000516
name: Binding of Csk and PEP in cytosol
xref_analog: IMR:0000212
xref_analog: IMR:0100342
xref_analog: PubMed:11781344
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000513 ! Lck inactivation signaling (through PTP)
relationship: part_of IEV:0001890 ! Lck inactivation signaling (through Csk)

[Term]
id: IEV:0000517
name: DNA fragmentation by EndoG in inner space of nucleus
xref_analog: UniProt:Q14249
is_a: IEV:0001051 ! Hydrolysis in inner space of nucleus
relationship: part_of IEV:0001602 ! EndoG mediated signaling

[Term]
id: IEV:0000518
name: Dephosphorylation of Lck_p by PEP in cytosol
exact_synonym: "Dephosphorylation of Lck_p (autophosphorylated) by PEP in cytosol" []
xref_analog: IMR:0100342
xref_analog: IMR:0100353
xref_analog: PubMed:11781344
is_a: IEV:0001592 ! Dephosphorylation of Lck_p by PTP in cytosol

[Term]
id: IEV:0000519
name: Lck activation signaling (through autophosphorylation and PTP)
xref_analog: IMR:0000273
xref_analog: PubMed:11781344
xref_analog: PubMed:12040176
xref_analog: PubMed:15034556
is_a: IEV:0001606 ! Src family activation signaling (through autophosphorylation and PTP)
is_a: IEV:0001610 ! Lck activation signaling
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000520
name: Regulation of Src family activation signaling
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0001589 ! Src family activation signaling

[Term]
id: IEV:0000521
name: Binding of antigen  and MHC II in extracellular
xref_analog: IMR:0000144
xref_analog: IMR:0000465
xref_analog: PubMed:15343367
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000522
name: Phosphorylation of CD3 zeta by Lck_p in cytosol
exact_synonym: "Phosphorylation of CD3 zeta by Lck (autophosphorylated) in cytosol" []
xref_analog: IMR:0100287
xref_analog: IMR:0100353
xref_analog: PubMed:12040176
is_a: IEV:0001253 ! Phosphorylation of CD3 zeta by non-receptor tyrosine kinase in cytosol

[Term]
id: IEV:0000523
name: Phosphorylation of CD3 zeta by Fyn_p in cytosol
exact_synonym: "Phosphorylation of CD3 zeta by Fyn (autophosphorylated) in cytosol" []
xref_analog: IMR:0100287
xref_analog: IMR:0100352
is_a: IEV:0001253 ! Phosphorylation of CD3 zeta by non-receptor tyrosine kinase in cytosol

[Term]
id: IEV:0000524
name: Binding of CD3 zeta and ZAP-70 in cytosol
alt_id: IEV:0000261
exact_synonym: "Binding of TCR-CD3 complex and Zap-70" []
xref_analog: IMR:0000221
xref_analog: IMR:0100287
xref_analog: PubMed:15343367
is_a: IEV:0001252 ! Binding of TCR-CD3 complex and non-receptor tyrosine kinase in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000525
name: Phosphorylation of ZAP-70 by Fyn_p in cytosol
exact_synonym: "Phosphorylation of ZAP-70 by autophosphorylated Fyn in cytosol" []
xref_analog: IMR:0000221
xref_analog: IMR:0100352
is_a: IEV:0000573 ! Phosphorylation of ZAP-70 by non-receptor tyrosine kinase in cytosol

[Term]
id: IEV:0000526
name: Dephosphorylation of ZAP-70_p by SHIP-1 in cytosol
xref_analog: IMR:0000221
xref_analog: IMR:0000271
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0002251 ! Negative regulation of (Phosphorylation of ZAP-70 by Lck_PY)

[Term]
id: IEV:0000527
name: Phosphorylation of SLP-76 by ZAP-70_p in cytosol
alt_id: IEV:0000290
exact_synonym: "Phosphorylation of SLP-76 by Zap-70" []
xref_analog: IMR:0000221
xref_analog: IMR:0000350
xref_analog: PubMed:15343367
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000528
name: Binding of Gads and SLP-76 in cytosol
xref_analog: IMR:0000350
xref_analog: IMR:0000741
xref_analog: PubMed:15343367
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000529
name: Phosphorylation of PLC gamma1 by Itk in cytosol
def: "T-cell" [XX:<new dbxref>]
xref_analog: IMR:0000732
xref_analog: IMR:0100354
xref_analog: PubMed:11752630
is_a: IEV:0000286 ! Phosphorylation of PLC gamma by non-receptor tyrosine kinase in cytosol

[Term]
id: IEV:0000530
name: Phosphorylation of PLC gamma by Syk in cytosol
xref_analog: IMR:0000222
xref_analog: IMR:0000285
xref_analog: PubMed:14632637
is_a: IEV:0000286 ! Phosphorylation of PLC gamma by non-receptor tyrosine kinase in cytosol

[Term]
id: IEV:0000531
name: Binding of SLP-76 and Itk in cytosol
xref_analog: IMR:0000350
xref_analog: IMR:0100354
xref_analog: PubMed:12040176
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000532
name: Phosphorylation of PI by PI4K in plasma membrane
xref_analog: IMR:0001651
xref_analog: IMR:0100699
is_a: IEV:0000198 ! Phosphorylation in plasma membrane
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000533
name: Phosphorylation of PIP by PI5K in plasma membrane
xref_analog: IMR:0000268
xref_analog: IMR:0001348
is_a: IEV:0000198 ! Phosphorylation in plasma membrane
relationship: part_of IEV:0001262 ! Rho-PI5K signaling

[Term]
id: IEV:0000534
name: Binding of PIP2 and actin-binding protein in cytosol
xref_analog: IMR:0001350
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000535
name: Fyn activation signaling (through autophosphorylation and PTP)
xref_analog: IMR:0000273
xref_analog: PubMed:15034556
is_a: IEV:0001606 ! Src family activation signaling (through autophosphorylation and PTP)
is_a: IEV:0001609 ! Fyn activation signaling
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000536
name: Autophosphorylation of Fyn and active conformational change in cytosol
xref_analog: IMR:0100352
xref_analog: PubMed:15034556
is_a: IEV:0001607 ! Autophosphorylation of Src family and active conformational change in cytosol
relationship: part_of IEV:0000535 ! Fyn activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0000537
name: Interaction in nucleus
def: "OBSOLETE: remap to 'Unknown interaction' IEV:0000922." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0000538
name: Regulation of BAD inactivation signaling
exact_synonym: "Regulation of BAD phosphorylation signaling" []
is_obsolete: true

[Term]
id: IEV:0000539
name: Regulation of Caspase cascade
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000128 ! Caspase Cascade

[Term]
id: IEV:0000540
name: Positive regulation of BAD inactivation signaling
exact_synonym: "Positive regulation of BAD phosphorylation signaling" []
is_obsolete: true

[Term]
id: IEV:0000541
name: Positive regulation of Caspase cascade (through mitochondria)
is_a: IEV:0001018 ! Regulation of Caspase cascade (through mitochondria)
is_a: IEV:0001020 ! Positive regulation of Caspase cascade
relationship: positively_regulates IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0000542
name: Regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
exact_synonym: "Regulation of CD4 T cell receptor signaling pathway (through PLC gamma, PKC and IKK-NF-kappaB cascade)" []
is_a: IEV:0001374 ! Regulation of T cell receptor signaling pathway
relationship: regulates IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000543
name: Positive regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
exact_synonym: "Positive regulation of CD4 T cell receptor signaling pathway (through PLC gamma, PKC and IKK-NF-kappaB cascade)" []
is_a: IEV:0000542 ! Regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0001376 ! Positive regulation of T cell receptor signaling pathway
relationship: positively_regulates IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000544
name: Regulation of Fas signaling pathway
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0001397 ! Fas signaling pathway

[Term]
id: IEV:0000545
name: Positive regulation of Fas signaling pathway
is_a: IEV:0000544 ! Regulation of Fas signaling pathway
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0001397 ! Fas signaling pathway

[Term]
id: IEV:0000546
name: Regulation of G1-S-phase transition
is_a: IEV:0001403 ! Regulation of cell cycle process
relationship: regulates IEV:0001070 ! G1-S-phase transition

[Term]
id: IEV:0000547
name: Positive regulation of G1-S-phase transition
is_a: IEV:0000546 ! Regulation of G1-S-phase transition
is_a: IEV:0001405 ! Positive regulation of cell cycle process
relationship: positively_regulates IEV:0001070 ! G1-S-phase transition

[Term]
id: IEV:0000548
name: Regulation of insulin receptor signaling pathway
def: "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GO:0046626]
xref_analog: GO:0046626
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000549
name: Positive regulation of insulin receptor signaling pathway
def: "Any process that increases the frequency, rate or extent of insulin receptor signaling." [GO:0046628]
xref_analog: GO:0046628
is_a: IEV:0000548 ! Regulation of insulin receptor signaling pathway
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000550
name: Regulation of JAK STAT pathway
def: "Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GO:0046425]
xref_analog: GO:0046425
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000551
name: Positive regulation of JAK STAT pathway
def: "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GO:0046427]
xref_analog: GO:0046427
is_a: IEV:0000550 ! Regulation of JAK STAT pathway
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000552
name: Regulation of NF-kappaB signaling (cytoplasmic sequestering)
is_a: IEV:0003681 ! signal transduction regulation pathway

[Term]
id: IEV:0000553
name: Positive regulation of NF-kappaB signaling (cytoplasmic sequestering)
is_a: IEV:0000552 ! Regulation of NF-kappaB signaling (cytoplasmic sequestering)
is_a: IEV:0001669 ! Positive signal transduction regulation pathway

[Term]
id: IEV:0000554
name: Regulation of PLC gamma signaling
is_a: IEV:0001407 ! Regulation of PLC signaling
is_a: IEV:0001796 ! Regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: regulates IEV:0000467 ! PLC gamma signaling

[Term]
id: IEV:0000555
name: Positive regulation of PLC gamma signaling (through LAT)
is_a: IEV:0000554 ! Regulation of PLC gamma signaling
is_a: IEV:0001409 ! Positive regulation of PLC signaling
is_a: IEV:0001798 ! Positive regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: positively_regulates IEV:0000467 ! PLC gamma signaling

[Term]
id: IEV:0000556
name: Regulation of Ras-Raf-MAPK signaling by spred [Drosophila]
def: "OBSOLETE: remap to 'Regulation of Ras-Raf-MAPK signaling by spred' IEV:0003543." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0000557
name: Positive regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
def: "OBSOLETE: remap to 'Positive regulation of Ras-Raf-MAPK signaling by spred' IEV:0003545." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0000558
name: Fyn inactivation signaling (through PTP)
xref_analog: IMR:0000273
xref_analog: PubMed:11781344
xref_analog: PubMed:15034556
is_a: IEV:0001634 ! Fyn inactivation signaling
is_a: IEV:0001888 ! Negative regulation of (Autophosphorylation of Fyn) in Fyn activation signaling
is_a: IEV:0002256 ! Negative regulation of (Fyn activation signaling)

[Term]
id: IEV:0000559
name: Negative regulation of Src family activation signaling
is_a: IEV:0000520 ! Regulation of Src family activation signaling
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0001589 ! Src family activation signaling

[Term]
id: IEV:0000560
name: Positive regulation of Src family activation signaling
is_a: IEV:0000520 ! Regulation of Src family activation signaling
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0001589 ! Src family activation signaling

[Term]
id: IEV:0000561
name: ZAP-70 and CD3 degradation signaling
xref_analog: PubMed:11724969
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
is_a: IEV:0002253 ! Negative regulation of (Phosphorylation of LAT by ZAP-70)
is_a: IEV:0002254 ! Negative regulation of (Phosphorylation of Vav by ZAP-70)

[Term]
id: IEV:0000562
name: Ubiquitination of ZAP-70 by c-Cbl in cytosol
xref_analog: IMR:0000221
xref_analog: IMR:0100344
xref_analog: PubMed:11724969
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000561 ! ZAP-70 and CD3 degradation signaling

[Term]
id: IEV:0000563
name: Ubiquitination of CD3_p by c-Cbl in cytosol
xref_analog: IMR:0000147
xref_analog: IMR:0100344
xref_analog: PubMed:11724969
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000561 ! ZAP-70 and CD3 degradation signaling

[Term]
id: IEV:0000564
name: Proteasome degradation of ZAP-70 by 26S proteasome in cytosol
xref_analog: IMR:0000221
xref_analog: IMR:0000310
xref_analog: PubMed:11724969
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000561 ! ZAP-70 and CD3 degradation signaling

[Term]
id: IEV:0000565
name: Proteasome degradation of CD3 by 26S proteasome in cytosol
xref_analog: IMR:0000147
xref_analog: IMR:0000310
xref_analog: PubMed:11724969
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000561 ! ZAP-70 and CD3 degradation signaling

[Term]
id: IEV:0000566
name: Syk degradation signaling
xref_analog: PubMed:12024036
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
is_a: IEV:0002257 ! Negative regulation of (Phosphorylation of Vav by Syk)

[Term]
id: IEV:0000567
name: Ubiquitination of Syk by c-Cbl in cytosol
xref_analog: IMR:0000222
xref_analog: IMR:0100344
xref_analog: PubMed:12024036
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000566 ! Syk degradation signaling

[Term]
id: IEV:0000568
name: Proteasome degradation of Syk by 26S proteasome in cytosol
xref_analog: IMR:0000222
xref_analog: IMR:0000310
xref_analog: PubMed:12024036
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000566 ! Syk degradation signaling

[Term]
id: IEV:0000569
name: Lck degradation signaling
xref_analog: PubMed:11904433
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
is_a: IEV:0002255 ! Negative regulation of (Lck activation signaling)

[Term]
id: IEV:0000570
name: Ubiquitination of Lck by c-Cbl in cytosol
xref_analog: IMR:0100344
xref_analog: IMR:0100353
xref_analog: PubMed:11904433
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000569 ! Lck degradation signaling

[Term]
id: IEV:0000571
name: Proteasome degradation of Lck by 26S proteasome in cytosol
xref_analog: IMR:0000310
xref_analog: IMR:0100353
xref_analog: PubMed:11904433
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000569 ! Lck degradation signaling

[Term]
id: IEV:0000572
name: Binding of PACAP and PACAP receptor in cytosol
xref_analog: REACT:18424.1
xref_analog: UniProt:P18509
xref_analog: UniProt:P41586
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000276 ! Heterotrimeric GPCR signaling pathway (through PACAP, G alpha s and adenylate cyclase, cAMP and PKA)

[Term]
id: IEV:0000573
name: Phosphorylation of ZAP-70 by non-receptor tyrosine kinase in cytosol
xref_analog: IMR:0000221
xref_analog: IMR:0000682
xref_analog: PubMed:12040176
xref_analog: PubMed:15343367
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000574
name: Embryonic morphogenesis
def: "The developmental processes by which defined structures within an embryo are generated." [GO:0048598]
xref_analog: GO:0048598
is_a: IEV:0000447 ! Anatomical structure morphogenesis
relationship: part_of IEV:0000397 ! Embryonic development

[Term]
id: IEV:0000575
name: Post-embryonic morphogenesis
def: "The process, occurring after embryonic development, by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GO:0009886]
exact_synonym: "post-embryonic morphogenesis of an anatomical structure" []
xref_analog: GO:0009886
is_a: IEV:0000447 ! Anatomical structure morphogenesis
relationship: part_of IEV:0000398 ! Post embryonic development

[Term]
id: IEV:0000576
name: Organ morphogenesis
def: "Morphogenesis of a tissue or tissues that function together to perform a specific function. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GO:0009887]
exact_synonym: "histogenesis and organogenesis" [GO:0009887]
xref_analog: GO:0009887
is_a: IEV:0000447 ! Anatomical structure morphogenesis
relationship: part_of IEV:0002712 ! Organ development

[Term]
id: IEV:0000577
name: Flower morphogenesis
def: "The process by which the anatomical structures of the flower are generated and organized. Morphogenesis pertains to the creation of form." [GO:0048439]
xref_analog: GO:0048439
is_a: IEV:0000575 ! Post-embryonic morphogenesis
relationship: part_of IEV:0000141 ! Flower development

[Term]
id: IEV:0000578
name: Tissue regeneration
alt_id: IEV:0000100
def: "The regrowth of lost or destroyed tissues." [GO:0042246]
exact_synonym: "Tissue repair" []
xref_analog: GO:0042246
is_a: IEV:0000142 ! Growth
is_a: IEV:0003796 ! Tissue development
relationship: part_of IEV:0001342 ! Wound healing

[Term]
id: IEV:0000579
name: Binding of extracellular matrix and Integrin complex in extracellular
xref_analog: IMR:0000172
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)

[Term]
id: IEV:0000580
name: Binding of extracellular matrix protein and integrin complex in extracellular
xref_analog: IMR:0000172
xref_analog: IMR:0000540
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)

[Term]
id: IEV:0000581
name: Complex formation of integrin complex and caveolin in plasma membrane
exact_synonym: "Integrin complex and caveolin complex formation" []
xref_analog: IMR:0000172
xref_analog: IMR:0000515
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)

[Term]
id: IEV:0000582
name: Binding of integrin complex and talin in cytosol
xref_analog: IMR:0000172
xref_analog: IMR:0001714
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein in cytosol

[Term]
id: IEV:0000583
name: Complex formation of integrin-dependent membrane-skeletal protein in cytosol
xref_analog: IMR:0000185
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)

[Term]
id: IEV:0000584
name: Binding of integrin complex and FAK in cytosol
xref_analog: IMR:0000172
xref_analog: IMR:0000218
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein in cytosol

[Term]
id: IEV:0000585
name: Binding of Integrin complex and tensin in cytosol
xref_analog: IMR:0000172
xref_analog: UniProt:Q9HBL0
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein in cytosol

[Term]
id: IEV:0000586
name: Binding of FAK and paxillin in cytosol
xref_analog: IMR:0000187
xref_analog: IMR:0000218
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein in cytosol

[Term]
id: IEV:0000587
name: Binding of FAK and p130Cas in cytosol
xref_analog: IMR:0000218
xref_analog: IMR:0000355
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein in cytosol

[Term]
id: IEV:0000588
name: Binding of alpha-actinin and F actin in cytosol
xref_analog: IMR:0000189
xref_analog: IMR:0000190
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein in cytosol

[Term]
id: IEV:0000589
name: Binding of tensin and F actin in cytosol
xref_analog: IMR:0000190
xref_analog: UniProt:Q9HBL0
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein in cytosol

[Term]
id: IEV:0000590
name: Binding of vinculin and F actin in cytosol
xref_analog: IMR:0000190
xref_analog: IMR:0001711
xref_analog: PubMed:8632828
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein in cytosol

[Term]
id: IEV:0000591
name: Binding of talin and F actin in cytosol
xref_analog: IMR:0000190
xref_analog: IMR:0001714
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein in cytosol

[Term]
id: IEV:0000592
name: Binding of alpha-actinin and zyxin in cytosol
xref_analog: IMR:0000189
xref_analog: UniProt:Q15942
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein in cytosol

[Term]
id: IEV:0000593
name: Autophosphorylation of FAK in cytosol
xref_analog: IMR:0000218
is_a: IEV:0000481 ! Autophosphorylation in cytosol
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)

[Term]
id: IEV:0000594
name: Phosphorylation of FAK by Src family in cytosol
xref_analog: IMR:0000211
xref_analog: IMR:0000218
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)

[Term]
id: IEV:0000595
name: Phosphorylation of p130Cas by Src family in cytosol
xref_analog: IMR:0000211
xref_analog: IMR:0000355
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)

[Term]
id: IEV:0000596
name: Phosphorylation of paxillin by Src family in cytosol
xref_analog: IMR:0000187
xref_analog: IMR:0000211
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)

[Term]
id: IEV:0000597
name: Binding of FAK and Src family in cytosol
xref_analog: IMR:0000211
xref_analog: IMR:0000218
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein in cytosol

[Term]
id: IEV:0000598
name: Binding of p130Cas and Crk in cytosol
xref_analog: IMR:0000335
xref_analog: IMR:0000355
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein in cytosol

[Term]
id: IEV:0000599
name: Binding of FAK and Grb2 in cytosol
xref_analog: IMR:0000218
xref_analog: IMR:0000340
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein in cytosol

[Term]
id: IEV:0000600
name: Binding of Fyn and Shc in cytosol
xref_analog: IMR:0000347
xref_analog: IMR:0100352
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein in cytosol
relationship: part_of IEV:0002526 ! Complex formation of integrin complex, caveolin-1, Fyn and Shc

[Term]
id: IEV:0000601
name: Phosphorylation of Shc by Fyn in cytosol
xref_analog: IMR:0000347
xref_analog: IMR:0100352
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)

[Term]
id: IEV:0000602
name: Raf activation signaling (through Grb2 and Sos)
exact_synonym: "Grb2-Sos-Ras-Raf signaling" []
is_a: IEV:0001258 ! Ras mediated signaling
is_a: IEV:0002072 ! Raf activation signaling
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000126 ! Insulin receptor signaling pathway (through Shc mediated signaling)
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000452 ! Insulin receptor signaling pathway (through IRS mediated signaling)
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000865 ! EGF receptor signaling pathway
relationship: part_of IEV:0000866 ! NGF receptor signaling pathway
relationship: part_of IEV:0001257 ! PDGF receptor signaling pathway
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0002626 ! FGF receptor signaling pathway
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway
relationship: part_of IEV:0003405 ! FGFR1 signaling pathway

[Term]
id: IEV:0000603
name: Binding of Grb2 and Sos in cytosol
xref_analog: IMR:0000340
xref_analog: IMR:0000435
xref_analog: PubMed:15220003
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000060 ! Grb2-Sos-Ras-PI3K signaling
relationship: part_of IEV:0000602 ! Raf activation signaling (through Grb2 and Sos)
relationship: part_of IEV:0000848 ! RalGDS activation signaling (through Grb2 and Sos)

[Term]
id: IEV:0000604
name: GDP-GTP exchange of Ras by Sos in cytosol
xref_analog: IMR:0000290
xref_analog: IMR:0000435
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: PubMed:15220003
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0000060 ! Grb2-Sos-Ras-PI3K signaling
relationship: part_of IEV:0000602 ! Raf activation signaling (through Grb2 and Sos)
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000848 ! RalGDS activation signaling (through Grb2 and Sos)

[Term]
id: IEV:0000605
name: GDP-GTP exchange in cytosol
is_a: IEV:0000223 ! GDP-GTP exchange

[Term]
id: IEV:0000606
name: GDP-GTP exchange in unidentified cellular location
is_a: IEV:0000223 ! GDP-GTP exchange

[Term]
id: IEV:0000607
name: Transference in cytosol
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0000608
name: Activation of Raf by Ras-GTP in cytosol
xref_analog: IMR:0000231
xref_analog: IMR:0000290
xref_analog: IMR:0001354
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000602 ! Raf activation signaling (through Grb2 and Sos)
relationship: part_of IEV:0002199 ! Raf activation signaling (through RasGRP)

[Term]
id: IEV:0000609
name: Binding of Ras-GTP and PI3K in cytosol
xref_analog: IMR:0000265
xref_analog: IMR:0000290
xref_analog: IMR:0001354
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000060 ! Grb2-Sos-Ras-PI3K signaling

[Term]
id: IEV:0000610
name: Regulation of integrin signaling pathway
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000124 ! Integrin signaling pathway

[Term]
id: IEV:0000611
name: Negative regulation of integrin signaling pathway
is_a: IEV:0000610 ! Regulation of integrin signaling pathway
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0000124 ! Integrin signaling pathway

[Term]
id: IEV:0000612
name: Positive regulation of integrin signaling pathway
is_a: IEV:0000610 ! Regulation of integrin signaling pathway
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0000124 ! Integrin signaling pathway

[Term]
id: IEV:0000613
name: Dephosphorylation of FAK by PTEN in cytosol
xref_analog: IMR:0000218
xref_analog: IMR:0100701
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0000611 ! Negative regulation of integrin signaling pathway

[Term]
id: IEV:0000614
name: Binding of Shc_p and Grb2 in cytosol
xref_analog: IMR:0000340
xref_analog: IMR:0000347
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000126 ! Insulin receptor signaling pathway (through Shc mediated signaling)
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein in cytosol
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
relationship: part_of IEV:0000865 ! EGF receptor signaling pathway
relationship: part_of IEV:0000866 ! NGF receptor signaling pathway
relationship: part_of IEV:0001257 ! PDGF receptor signaling pathway
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway
relationship: part_of IEV:0003559 ! IGF1 signaling pathway

[Term]
id: IEV:0000615
name: Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
xref_analog: KEGG:hsa04510
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000104 ! Cell migration
relationship: part_of IEV:0000124 ! Integrin signaling pathway
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000616
name: Integrin signaling pathway (through Rho)
xref_analog: KEGG:hsa04510
xref_analog: KEGG:hsa04810
xref_analog: KEGG:mmu04810
xref_analog: KEGG:rno04810
relationship: part_of IEV:0000091 ! Cell growth
relationship: part_of IEV:0000095 ! Stress fiber formation
relationship: part_of IEV:0000104 ! Cell migration
relationship: part_of IEV:0000105 ! Cell adhesion
relationship: part_of IEV:0000124 ! Integrin signaling pathway
relationship: part_of IEV:0000578 ! Tissue regeneration
relationship: part_of IEV:0000637 ! Actin polymerization and/or depolymerization
relationship: part_of IEV:0001199 ! Actomyosin structure organization and biogenesis

[Term]
id: IEV:0000617
name: Phosphorylation of ERK by FAK in cytosol
xref_analog: IMR:0000218
xref_analog: IMR:0000227
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)

[Term]
id: IEV:0000618
name: Integrin signaling pathway (through Rac and JNK cascade)
xref_analog: KEGG:hsa04510
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000124 ! Integrin signaling pathway

[Term]
id: IEV:0000619
name: Activation of MLCK by ERK_p in cytosol
xref_analog: IMR:0000227
xref_analog: UniProt:Q15746
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)

[Term]
id: IEV:0000620
name: Binding of integrin complex and Ilk in cytosol
xref_analog: IMR:0000172
xref_analog: UniProt:Q13418
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein in cytosol

[Term]
id: IEV:0000621
name: Binding of FAK and PI3K in cytosol
def: "PI3K approaching to the plasma membrane" [XX:<new dbxref>]
xref_analog: IMR:0000218
xref_analog: IMR:0000265
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)

[Term]
id: IEV:0000622
name: Binding of PIP3 and AKT
xref_analog: IMR:0000250
xref_analog: IMR:0001352
is_a: IEV:0000174 ! Binding outside the mitochondria membrane
relationship: part_of IEV:0001484 ! AKT(PKB) activation signaling

[Term]
id: IEV:0000623
name: Phosphorylation of AKT by IlK in cytosol
xref_analog: IMR:0000250
xref_analog: UniProt:Q13418
is_a: IEV:0002415 ! Phosphorylation of Akt by protein kinase in cytosol

[Term]
id: IEV:0000624
name: Phosphorylation outside the mitochondria membrane
is_a: IEV:0000025 ! Phosphorylation in cytosol

[Term]
id: IEV:0000625
name: Binding of PIP3 and PDK1
xref_analog: IMR:0000255
xref_analog: IMR:0001352
is_a: IEV:0000174 ! Binding outside the mitochondria membrane
relationship: part_of IEV:0001484 ! AKT(PKB) activation signaling

[Term]
id: IEV:0000626
name: Phosphorylation of Vav by Syk in cytosol
xref_analog: IMR:0000222
xref_analog: IMR:0000434
xref_analog: PubMed:9843681
is_a: IEV:0000264 ! Phosphorylation of Vav by non-receptor tyrosine kinase in cytosol
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000627
name: GDP-GTP exchange of Rac by Vav in cytosol
xref_analog: IMR:0000297
xref_analog: IMR:0000434
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: PubMed:12818159
xref_analog: PubMed:15343367
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)

[Term]
id: IEV:0000628
name: Activation of PAK by Rac in cytosol
xref_analog: IMR:0000238
xref_analog: IMR:0000297
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)
relationship: part_of IEV:0000659 ! Rac/Cdc42-PAK-MLCK signaling

[Term]
id: IEV:0000629
name: Phosphorylation of MAPKKK by PAK in cytosol
xref_analog: IMR:0000229
xref_analog: IMR:0000238
is_a: IEV:0000633 ! Phosphorylation of MAPKKK by MAPKKKK in cytosol
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)

[Term]
id: IEV:0000630
name: Binding of Crk and C3G in cytosol
xref_analog: IMR:0000335
xref_analog: IMR:0000436
xref_analog: PubMed:11804588
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)
relationship: part_of IEV:0001257 ! PDGF receptor signaling pathway
relationship: part_of IEV:0002081 ! Rap1 activation signaling (through cAMP, PKA, Cbl and C3G)
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0000631
name: GDP-GTP exchange of Rap1 by C3G in cytosol
xref_analog: IMR:0000436
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: IMR:0001504
xref_analog: PubMed:9560161
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)
relationship: part_of IEV:0002081 ! Rap1 activation signaling (through cAMP, PKA, Cbl and C3G)
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0000632
name: Activation of MAPKKKK by Rap1 in cytosol
xref_analog: IMR:0001504
xref_analog: IMR:0100207
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)

[Term]
id: IEV:0000633
name: Phosphorylation of MAPKKK by MAPKKKK in cytosol
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase." [GO:0000185]
exact_synonym: "activation of MAP kinase kinase kinase" []
exact_synonym: "activation of MAPKKK activity" []
xref_analog: GO:0000185
xref_analog: GO:0042655
xref_analog: IMR:0000229
xref_analog: IMR:0100207
is_a: IEV:0002086 ! Phosphorylation of MAPKKK by non-receptor serine/threonine kinase in cytosol
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)

[Term]
id: IEV:0000634
name: GDP-GTP exchange of Rac by Dock180 in cytosol
xref_analog: IMR:0000297
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: IMR:0001468
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0000635
name: Complex formation of RhoG, Elmo and Dock180 in cytosol
xref_analog: IMR:0001468
xref_analog: PubMed:12879077
xref_analog: UniProt:P84095
xref_analog: UniProt:Q92556
xref_analog: UniProt:Q96JJ3
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)

[Term]
id: IEV:0000636
name: Binding of PIP2 and gelsolin in cytosol
xref_analog: IMR:0001350
xref_analog: UniProt:P06396
is_a: IEV:0000534 ! Binding of PIP2 and actin-binding protein in cytosol

[Term]
id: IEV:0000637
name: Actin polymerization and/or depolymerization
def: "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GO:0008154]
xref_analog: GO:0008154
is_a: IEV:0000092 ! Cytoskeleton organization

[Term]
id: IEV:0000638
name: Actin filament depolymerization
def: "Disassembly of actin filaments by the removal of actin monomers from a filament." [GO:0030042]
exact_synonym: "Actin depolymerization" []
xref_analog: GO:0030042
is_a: IEV:0000637 ! Actin polymerization and/or depolymerization

[Term]
id: IEV:0000639
name: Actin filament polymerization
def: "Assembly of actin filaments by the addition of actin monomers to a filament." [GO:0030041]
exact_synonym: "Actin polymerization" []
xref_analog: GO:0030041
is_a: IEV:0000637 ! Actin polymerization and/or depolymerization

[Term]
id: IEV:0000640
name: Binding of PIP2 and profilin in cytosol
xref_analog: IMR:0000194
xref_analog: IMR:0001350
is_a: IEV:0000534 ! Binding of PIP2 and actin-binding protein in cytosol

[Term]
id: IEV:0000641
name: Binding of PIP2 and cofilin in cytosol
xref_analog: IMR:0001350
xref_analog: UniProt:P23528
xref_analog: UniProt:Q9Y281
is_a: IEV:0000534 ! Binding of PIP2 and actin-binding protein in cytosol

[Term]
id: IEV:0000642
name: Binding of PIP2 and actinin in cytosol
xref_analog: IMR:0000189
xref_analog: IMR:0001350
is_a: IEV:0000534 ! Binding of PIP2 and actin-binding protein in cytosol

[Term]
id: IEV:0000643
name: Binding of PIP2 and vinculin in cytosol
xref_analog: IMR:0001350
xref_analog: IMR:0001711
xref_analog: PubMed:8632828
is_a: IEV:0000534 ! Binding of PIP2 and actin-binding protein in cytosol

[Term]
id: IEV:0000644
name: Binding of vinculin and talin in cytosol
xref_analog: IMR:0001711
xref_analog: IMR:0001714
xref_analog: PubMed:8632828
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein in cytosol

[Term]
id: IEV:0000645
name: Binding of PIP2 and ERM in cytosol
xref_analog: IMR:0001093
xref_analog: IMR:0001350
is_a: IEV:0000534 ! Binding of PIP2 and actin-binding protein in cytosol

[Term]
id: IEV:0000646
name: Activation of ERM by PIP2 in cytosol
xref_analog: IMR:0001093
xref_analog: IMR:0001350
xref_analog: PubMed:12045227
xref_analog: PubMed:8858161
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000647
name: Activation of PI5K by Rho in cytosol
xref_analog: IMR:0000268
xref_analog: IMR:0000296
xref_analog: PubMed:7954816
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0001262 ! Rho-PI5K signaling

[Term]
id: IEV:0000648
name: Y-27632 medication
def: "Inhibitor of p160ROCK" [XX:<new dbxref>]
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0000649
name: Activation of p160ROCK by Rho in cytosol
xref_analog: IMR:0000296
xref_analog: UniProt:Q13464
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0001261 ! Rho-p160-myosin phosphatase signaling

[Term]
id: IEV:0000650
name: Phosphorylation of myosin phosphatase by p160ROCK in cytosol
def: "Inactivation of myosin phosphatase" [XX:<new dbxref>]
xref_analog: PubMed:8662509
xref_analog: UniProt:Q13464
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001261 ! Rho-p160-myosin phosphatase signaling

[Term]
id: IEV:0000651
name: Phosphorylation of MLC by MLCK in cytosol
xref_analog: IMR:0000191
xref_analog: UniProt:Q15746
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000652
name: Phosphorylation of LIM-kinase by p160ROCK in cytosol
xref_analog: UniProt:P53667
xref_analog: UniProt:Q13464
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000653
name: Phosphorylation of cofilin by LIM-kinase in cytosol
xref_analog: PubMed:9655398
xref_analog: UniProt:P23528
xref_analog: UniProt:P53667
xref_analog: UniProt:Q9Y281
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000654
name: Phosphorylation of MLCK by ERK in cytosol
xref_analog: IMR:0000227
xref_analog: PubMed:9128257
xref_analog: UniProt:Q15746
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000655
name: Regulation of Integrin signaling pathway (through Rho)
is_a: IEV:0000610 ! Regulation of integrin signaling pathway
relationship: regulates IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000656
name: Negative regulation of Integrin signaling pathway (through Rho)
is_a: IEV:0000611 ! Negative regulation of integrin signaling pathway
is_a: IEV:0000655 ! Regulation of Integrin signaling pathway (through Rho)
relationship: negatively_regulates IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000657
name: Positive regulation of Integrin signaling pathway (through Rho)
is_a: IEV:0000612 ! Positive regulation of integrin signaling pathway
is_a: IEV:0000655 ! Regulation of Integrin signaling pathway (through Rho)
relationship: positively_regulates IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000658
name: Phosphorylation of MLCK by PAK in cytosol
xref_analog: IMR:0000238
xref_analog: PubMed:10092231
xref_analog: UniProt:Q15746
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000659 ! Rac/Cdc42-PAK-MLCK signaling

[Term]
id: IEV:0000659
name: Rac/Cdc42-PAK-MLCK signaling
xref_analog: KEGG:hsa04510
xref_analog: KEGG:hsa04810
xref_analog: KEGG:mmu04810
xref_analog: KEGG:rno04810
is_a: IEV:0000656 ! Negative regulation of Integrin signaling pathway (through Rho)
is_a: IEV:0001259 ! Rac mediated signaling
relationship: part_of IEV:0000095 ! Stress fiber formation

[Term]
id: IEV:0000660
name: Activation of PAK by Cdc42 in cytosol
xref_analog: IMR:0000238
xref_analog: IMR:0000699
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000659 ! Rac/Cdc42-PAK-MLCK signaling

[Term]
id: IEV:0000661
name: GPCR signaling pathway
def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GO:0007186]
exact_synonym: "G-protein coupled receptor protein signaling pathway" []
xref_analog: GO:0007186
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0000662
name: Binding of GPCR ligand and GPCR in extracellular
xref_analog: IMR:0000137
xref_analog: PubMed:14734786
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000661 ! GPCR signaling pathway
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)

[Term]
id: IEV:0000663
name: GDP-GTP exchange of G alpha in cytosol
xref_analog: IMR:0000316
xref_analog: IMR:0001354
xref_analog: IMR:0001357
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0002012 ! G alpha GDP-GTP exchange signaling

[Term]
id: IEV:0000664
name: Dissociation of G alpha-GTP and G beta:G gamma in cytosol
xref_analog: IMR:0000316
xref_analog: IMR:0001354
xref_analog: IMR:0100018
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0000665
name: Dissociation in plasma membrane
is_a: IEV:0000006 ! Dissociation

[Term]
id: IEV:0000666
name: Binding of G alpha-GTP and effector in cytosol
xref_analog: IMR:0000316
xref_analog: IMR:0001354
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0000667
name: Binding of G beta:G gamma and effector in cytosol
xref_analog: IMR:0100018
xref_analog: PubMed:14734786
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000661 ! GPCR signaling pathway
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)
relationship: part_of IEV:0000692 ! Heterotrimeric GPCR signaling pathway (through G alpha i)
relationship: part_of IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)

[Term]
id: IEV:0000668
name: Regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0000669
name: Negative regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000668 ! Regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0000670
name: Positive regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000668 ! Regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0000671
name: G alpha-GTP hydrolysis signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling
is_a: IEV:0000669 ! Negative regulation of heterotrimeric GPCR signaling pathway

[Term]
id: IEV:0000672
name: Hydrolysis of GTP by G alpha-GTP in cytosol
xref_analog: IMR:0001354
is_a: IEV:0003829 ! Hydrolysis of GTP by trimeric G-protein in cytosol
relationship: part_of IEV:0000671 ! G alpha-GTP hydrolysis signaling
relationship: part_of IEV:0002059 ! Negative regulation of (GDP-GTP exchange of G alpha)

[Term]
id: IEV:0000673
name: Hydrolysis in unidentified cellular location
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0000674
name: Binding of G alpha-GTP and RGS in cytosol
xref_analog: IMR:0000316
xref_analog: IMR:0000431
xref_analog: IMR:0001354
is_a: IEV:0000666 ! Binding of G alpha-GTP and effector in cytosol
relationship: part_of IEV:0000671 ! G alpha-GTP hydrolysis signaling

[Term]
id: IEV:0000675
name: Dissociation of G alpha-GDP and target protein in cytosol
xref_analog: IMR:0000316
xref_analog: IMR:0001357
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000671 ! G alpha-GTP hydrolysis signaling

[Term]
id: IEV:0000676
name: Small GTPase mediated signaling
def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GO:0007264]
exact_synonym: "small GTPase mediated signal transduction" [GO:0007264]
xref_analog: GO:0007264
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0000677
name: GDP-GTP exchange of small GTPase by GEF
is_obsolete: true

[Term]
id: IEV:0000678
name: Binding of small GTPase-GTP and target protein
is_obsolete: true

[Term]
id: IEV:0000679
name: Binding of small GTPase-GTP and GAP in cytosol
xref_analog: IMR:0000288
xref_analog: IMR:0000442
xref_analog: IMR:0001354
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000684 ! Small GTPase hydrolysis signaling

[Term]
id: IEV:0000680
name: Hydrolysis of GTP by small GTPase in cytosol
xref_analog: IMR:0000288
xref_analog: IMR:0001354
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000684 ! Small GTPase hydrolysis signaling

[Term]
id: IEV:0000681
name: Regulation of small GTPase mediated signaling
def: "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GO:0051056]
exact_synonym: "regulation of small GTPase mediated signal transduction" [GO:0051056]
xref_analog: GO:0051056
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000676 ! Small GTPase mediated signaling

[Term]
id: IEV:0000682
name: Positive regulation of small GTPase mediated signaling
def: "Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction." [GO:0051057]
exact_synonym: "positive regulation of small GTPase mediated signal transduction" [GO:0051057]
xref_analog: GO:0051057
is_a: IEV:0000681 ! Regulation of small GTPase mediated signaling
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0000676 ! Small GTPase mediated signaling

[Term]
id: IEV:0000683
name: Negative regulation of small GTPase mediated signaling
def: "Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase mediated signal transduction." [GO:0051058]
exact_synonym: "negative regulation of small GTPase mediated signal transduction" [GO:0051058]
xref_analog: GO:0051058
is_a: IEV:0000681 ! Regulation of small GTPase mediated signaling
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0000676 ! Small GTPase mediated signaling

[Term]
id: IEV:0000684
name: Small GTPase hydrolysis signaling
is_a: IEV:0000683 ! Negative regulation of small GTPase mediated signaling
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0000685
name: Hydrolysis in cytosol
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0000686
name: Binding of G alpha s-GTP and adenylate cyclase in cytosol
comment: Inactivation of ACs.
xref_analog: IMR:0000313
xref_analog: IMR:0001354
xref_analog: IMR:0100366
xref_analog: PubMed:14734786
is_a: IEV:0001992 ! Binding of G alpha s-GTP and effector in cytosol
relationship: part_of IEV:0000276 ! Heterotrimeric GPCR signaling pathway (through PACAP, G alpha s and adenylate cyclase, cAMP and PKA)
relationship: part_of IEV:0002021 ! Adenylate cyclase activation signaling
relationship: part_of IEV:0002028 ! cAMP concentration elevation

[Term]
id: IEV:0000687
name: Hydrolysis of ATP to cAMP by adenylate cyclase in cytosol
def: "The formation from simpler components of cyclic AMP, adenosine 3',5'-phosphate." [GO:0006171]
xref_analog: GO:0006171
xref_analog: IMR:0000313
xref_analog: IMR:0001351
xref_analog: IMR:0100024
xref_analog: PubMed:7814360
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000780 ! PKA activation signaling
relationship: part_of IEV:0002028 ! cAMP concentration elevation

[Term]
id: IEV:0000688
name: Dissociation of G alpha s-GDP and adenylate cyclase in cytosol
xref_analog: IMR:0000313
xref_analog: IMR:0001357
xref_analog: IMR:0100366
xref_analog: PubMed:11604548
is_a: IEV:0000675 ! Dissociation of G alpha-GDP and target protein in cytosol
relationship: part_of IEV:0000702 ! G alpha s-GTP hydrolysis signaling

[Term]
id: IEV:0000689
name: Binding of G alpha i-GTP and adenylate cyclase in cytosol
xref_analog: IMR:0000313
xref_analog: IMR:0000319
xref_analog: IMR:0001354
xref_analog: PubMed:14734786
is_a: IEV:0001997 ! Binding of G alpha i-GTP and effector in cytosol
relationship: part_of IEV:0002002 ! Negative regulation of (Binding of G alpha s-GTP and adenylate cyclase)
relationship: part_of IEV:0002022 ! Adenylate cyclase inactivation signaling

[Term]
id: IEV:0000690
name: Dissociation of G alpha i-GDP and adenylate cyclase in cytosol
xref_analog: IMR:0000313
xref_analog: IMR:0000319
xref_analog: IMR:0001357
is_a: IEV:0000675 ! Dissociation of G alpha-GDP and target protein in cytosol

[Term]
id: IEV:0000691
name: Heterotrimeric GPCR signaling pathway (through G alpha s)
xref_analog: GO:0007189
xref_analog: PubMed:14734786
is_a: IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0000692
name: Heterotrimeric GPCR signaling pathway (through G alpha i)
alt_id: IEV:0000716
exact_synonym: "Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin)" []
is_a: IEV:0000661 ! GPCR signaling pathway
relationship: part_of IEV:0000717 ! Whooping cough

[Term]
id: IEV:0000693
name: Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
is_a: IEV:0000669 ! Negative regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000731 ! Regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
relationship: negatively_regulates IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)

[Term]
id: IEV:0000694
name: Negative regulation of (G alpha i GDP-GTP exchange signaling)
is_a: IEV:0000669 ! Negative regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0002026 ! Negative regulation of heteromeric GPCR signaling pathway (through G alpha i)

[Term]
id: IEV:0000695
name: Positive regulation of heterotrimeric GPCR signaling pathway (through G alpha i)
is_a: IEV:0000670 ! Positive regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000730 ! Regulation of heterotrimeric GPCR signaling pathway (through G alpha i)
relationship: positively_regulates IEV:0000692 ! Heterotrimeric GPCR signaling pathway (through G alpha i)

[Term]
id: IEV:0000696
name: Positive regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
is_a: IEV:0000670 ! Positive regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000731 ! Regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
relationship: positively_regulates IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)

[Term]
id: IEV:0000697
name: Binding of G alpha i-GTP and RGS in cytosol
xref_analog: IMR:0000319
xref_analog: IMR:0000431
xref_analog: IMR:0001354
xref_analog: PubMed:8774883
is_a: IEV:0000674 ! Binding of G alpha-GTP and RGS in cytosol
is_a: IEV:0001997 ! Binding of G alpha i-GTP and effector in cytosol
relationship: part_of IEV:0000701 ! G alpha i-GTP hydrolysis signaling

[Term]
id: IEV:0000698
name: Hydrolysis of GTP by G alpha i-GTP and RGS in cytosol
xref_analog: IMR:0000431
xref_analog: IMR:0001354
xref_analog: PubMed:8774883
is_a: IEV:0000672 ! Hydrolysis of GTP by G alpha-GTP in cytosol
relationship: part_of IEV:0000701 ! G alpha i-GTP hydrolysis signaling
relationship: part_of IEV:0002060 ! Negative regulation of (GDP-GTP exchange of G alpha i)

[Term]
id: IEV:0000699
name: Binding of G alpha s-GTP and RGS in cytosol
xref_analog: IMR:0000431
xref_analog: IMR:0001354
xref_analog: IMR:0100366
xref_analog: PubMed:11604548
is_a: IEV:0000674 ! Binding of G alpha-GTP and RGS in cytosol
is_a: IEV:0001992 ! Binding of G alpha s-GTP and effector in cytosol
relationship: part_of IEV:0000702 ! G alpha s-GTP hydrolysis signaling

[Term]
id: IEV:0000700
name: Hydrolysis of GTP by G alpha s-GTP and RGS in cytosol
xref_analog: IMR:0000431
xref_analog: IMR:0001354
xref_analog: PubMed:11604548
is_a: IEV:0000672 ! Hydrolysis of GTP by G alpha-GTP in cytosol
relationship: part_of IEV:0000702 ! G alpha s-GTP hydrolysis signaling
relationship: part_of IEV:0002062 ! Negative regulation of (GDP-GTP exchange of G alpha s)

[Term]
id: IEV:0000701
name: G alpha i-GTP hydrolysis signaling
xref_analog: PubMed:8774883
is_a: IEV:0000671 ! G alpha-GTP hydrolysis signaling
relationship: part_of IEV:0000694 ! Negative regulation of (G alpha i GDP-GTP exchange signaling)

[Term]
id: IEV:0000702
name: G alpha s-GTP hydrolysis signaling
exact_synonym: "G alpha s inactivation signaling" []
xref_analog: PubMed:11604548
is_a: IEV:0000671 ! G alpha-GTP hydrolysis signaling
relationship: part_of IEV:0002004 ! Negative regulation of (G alpha s GDP-GTP exchange signaling)

[Term]
id: IEV:0000703
name: Ras-GTP hydrolysis signaling
is_a: IEV:0000684 ! Small GTPase hydrolysis signaling
is_a: IEV:0000704 ! Negative regulation of Ras mediated signaling
is_a: IEV:0000822 ! Negative regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
is_a: IEV:0000840 ! Negative regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
is_a: IEV:0000854 ! Negative regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
is_a: IEV:0000861 ! Negative regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000704
name: Negative regulation of Ras mediated signaling
def: "Any process that stops, prevents or reduces the rate, frequency or extent of Ras protein signal transduction." [GO:0046580]
exact_synonym: "negative regulation of Ras protein signal transduction" [GO:0046580]
xref_analog: GO:0046580
is_a: IEV:0000683 ! Negative regulation of small GTPase mediated signaling
is_a: IEV:0001401 ! Regulation of Ras mediated signaling
relationship: negatively_regulates IEV:0001258 ! Ras mediated signaling

[Term]
id: IEV:0000705
name: Hydrolysis of GTP by Ras in cytosol
xref_analog: IMR:0000290
xref_analog: IMR:0001354
is_a: IEV:0000680 ! Hydrolysis of GTP by small GTPase in cytosol
relationship: part_of IEV:0000602 ! Raf activation signaling (through Grb2 and Sos)
relationship: part_of IEV:0000703 ! Ras-GTP hydrolysis signaling

[Term]
id: IEV:0000706
name: Binding of Ras-GTP and GAP in cytosol
xref_analog: IMR:0000290
xref_analog: IMR:0000442
xref_analog: IMR:0001354
is_a: IEV:0000679 ! Binding of small GTPase-GTP and GAP in cytosol
relationship: part_of IEV:0000703 ! Ras-GTP hydrolysis signaling

[Term]
id: IEV:0000707
name: Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
is_a: IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)
relationship: part_of IEV:0000715 ! Diarrhea

[Term]
id: IEV:0000708
name: ADP-ribosylation of G alpha s by cholera toxin in cytosol
xref_analog: IMR:0100366
xref_analog: IMR:0100468
is_a: IEV:0000710 ! ADP ribosylation in cytosol
relationship: part_of IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)

[Term]
id: IEV:0000709
name: ADP ribosylation
def: "Reaction that can affect Arg, Cys, Glu, Arg and Asn residues." [MI:0557]
xref_analog: EC:2.4.5.30
xref_analog: EC:2.4.5.31
xref_analog: EC:2.4.5.36
xref_analog: EC:2.4.5.37
xref_analog: MI:0557
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0000710
name: ADP ribosylation in cytosol
is_a: IEV:0000709 ! ADP ribosylation

[Term]
id: IEV:0000711
name: ADP ribosylation in plasma membrane
is_a: IEV:0000709 ! ADP ribosylation

[Term]
id: IEV:0000712
name: Transference in unidentified cellular location
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0000713
name: Binding of G alpha s-GTP-ADPrib and adenylate cyclase in cytosol
xref_analog: IMR:0000313
xref_analog: IMR:0001354
xref_analog: IMR:0100366
is_a: IEV:0000686 ! Binding of G alpha s-GTP and adenylate cyclase in cytosol
relationship: part_of IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
relationship: part_of IEV:0002066 ! Negative regulation of (Hydrolysis of GTP by G alpha s-GTP and RGS) (through Adenylate cyclase activation signaling)

[Term]
id: IEV:0000714
name: Clinical presentation
is_a: IEV:0000075 ! Disease

[Term]
id: IEV:0000715
name: Diarrhea
def: "An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight." [MeSH:D003967]
xref_analog: MeSH:D003967
is_a: IEV:0000714 ! Clinical presentation

[Term]
id: IEV:0000717
name: Whooping cough
def: "A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath." [MeSH:D014917]
xref_analog: MeSH:D014917
is_a: IEV:0000075 ! Disease

[Term]
id: IEV:0000718
name: ADP ribosylation of G alpha i by pertussis toxin in cytosol
xref_analog: IMR:0000319
xref_analog: IMR:0100469
xref_analog: PubMed:9032437
is_a: IEV:0000710 ! ADP ribosylation in cytosol
relationship: part_of IEV:0002030 ! Negative regulation of (Binding of GPCR ligand and GPCR)

[Term]
id: IEV:0000719
name: Dissociation of G alpha i-GTP and G beta:G gamma in cytosol
xref_analog: IMR:0000319
xref_analog: IMR:0001354
xref_analog: IMR:0100018
is_a: IEV:0000664 ! Dissociation of G alpha-GTP and G beta:G gamma in cytosol
relationship: part_of IEV:0000692 ! Heterotrimeric GPCR signaling pathway (through G alpha i)
relationship: part_of IEV:0000701 ! G alpha i-GTP hydrolysis signaling

[Term]
id: IEV:0000720
name: GDP-GTP exchange of G alpha i in cytosol
xref_analog: IMR:0000319
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: PubMed:14734786
is_a: IEV:0000663 ! GDP-GTP exchange of G alpha in cytosol
relationship: part_of IEV:0002017 ! G alpha i GDP-GTP exchange signaling
relationship: part_of IEV:0002034 ! Negative regulation of (Hydrolysis of GTP by G alpha i-GTP and RGS)

[Term]
id: IEV:0000721
name: Dissociation of G alpha s-GTP and G beta:G gamma in cytosol
xref_analog: IMR:0001354
xref_analog: IMR:0100018
xref_analog: IMR:0100366
xref_analog: PubMed:14734786
is_a: IEV:0000664 ! Dissociation of G alpha-GTP and G beta:G gamma in cytosol
relationship: part_of IEV:0000276 ! Heterotrimeric GPCR signaling pathway (through PACAP, G alpha s and adenylate cyclase, cAMP and PKA)
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)
relationship: part_of IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)

[Term]
id: IEV:0000722
name: GDP-GTP exchange of G alpha s in cytosol
xref_analog: IMR:0000317
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: PubMed:14734786
is_a: IEV:0000663 ! GDP-GTP exchange of G alpha in cytosol
relationship: part_of IEV:0000276 ! Heterotrimeric GPCR signaling pathway (through PACAP, G alpha s and adenylate cyclase, cAMP and PKA)
relationship: part_of IEV:0002003 ! G alpha s GDP-GTP exchange signaling
relationship: part_of IEV:0002011 ! Negative regulation of (Hydrolysis of GTP by G alpha s-GTP and RGS) (through G alpha s GDP-GTP exchange signaling)

[Term]
id: IEV:0000723
name: Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)
def: "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon." [GO:0016056]
xref_analog: GO:0030265
is_a: IEV:0002636 ! Heterotrimeric GPCR signaling pathway (through G alpha t)
relationship: part_of IEV:0000121 ! Rhodopsin mediated signaling pathway

[Term]
id: IEV:0000724
name: Activation of rhodopsin by photon in extracellular
xref_analog: UniProt:P08100
is_a: IEV:0000725 ! Activation in extracellular
relationship: part_of IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)

[Term]
id: IEV:0000725
name: Activation in extracellular
is_a: IEV:0000008 ! Activation

[Term]
id: IEV:0000726
name: GDP-GTP exchange of G alpha t in cytosol
xref_analog: IMR:0000321
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: PubMed:14734786
is_a: IEV:0000663 ! GDP-GTP exchange of G alpha in cytosol
relationship: part_of IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)
relationship: part_of IEV:0002042 ! Negative regulation of (Hydrolysis of GTP by G alpha t-GTP and RGS)
relationship: part_of IEV:0002043 ! G alpha t GDP-GTP exchange signaling

[Term]
id: IEV:0000727
name: Dissociation of G alpha t-GTP and G beta:G gamma in cytosol
xref_analog: IMR:0000321
xref_analog: IMR:0001354
xref_analog: IMR:0100018
is_a: IEV:0000664 ! Dissociation of G alpha-GTP and G beta:G gamma in cytosol
relationship: part_of IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)

[Term]
id: IEV:0000728
name: Binding of G alpha t-GTP and cGMP PDE in cytosol
xref_analog: IMR:0000321
xref_analog: IMR:0001022
xref_analog: IMR:0001354
is_a: IEV:0002013 ! Binding of G alpha t-GTP and effector in cytosol
relationship: part_of IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)

[Term]
id: IEV:0000729
name: Hydrolysis of cGMP to GMP by cGMP PDE in cytosol
xref_analog: IMR:0001022
xref_analog: IMR:0100025
xref_analog: IMR:0200292
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)

[Term]
id: IEV:0000730
name: Regulation of heterotrimeric GPCR signaling pathway (through G alpha i)
is_a: IEV:0000668 ! Regulation of heterotrimeric GPCR signaling pathway
relationship: regulates IEV:0000692 ! Heterotrimeric GPCR signaling pathway (through G alpha i)

[Term]
id: IEV:0000731
name: Regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
is_a: IEV:0000668 ! Regulation of heterotrimeric GPCR signaling pathway
relationship: regulates IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)

[Term]
id: IEV:0000732
name: Regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)
is_a: IEV:0000668 ! Regulation of heterotrimeric GPCR signaling pathway
relationship: regulates IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)

[Term]
id: IEV:0000733
name: Negative regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)
is_a: IEV:0000669 ! Negative regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000732 ! Regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)
relationship: negatively_regulates IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)

[Term]
id: IEV:0000734
name: Positive regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)
is_a: IEV:0000670 ! Positive regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000732 ! Regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)
relationship: positively_regulates IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)

[Term]
id: IEV:0000735
name: G alpha t-GTP hydrolysis signaling
is_a: IEV:0000671 ! G alpha-GTP hydrolysis signaling
is_a: IEV:0000733 ! Negative regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)

[Term]
id: IEV:0000736
name: Binding of G alpha t-GTP and RGS in cytosol
xref_analog: IMR:0000321
xref_analog: IMR:0000431
xref_analog: IMR:0001354
is_a: IEV:0000674 ! Binding of G alpha-GTP and RGS in cytosol
is_a: IEV:0002013 ! Binding of G alpha t-GTP and effector in cytosol
relationship: part_of IEV:0000735 ! G alpha t-GTP hydrolysis signaling

[Term]
id: IEV:0000737
name: Dissociation of G alpha t-GDP and cGMP PDE in cytosol
xref_analog: IMR:0000321
xref_analog: IMR:0001022
xref_analog: IMR:0001357
is_a: IEV:0000675 ! Dissociation of G alpha-GDP and target protein in cytosol
relationship: part_of IEV:0000735 ! G alpha t-GTP hydrolysis signaling

[Term]
id: IEV:0000738
name: Hydrolysis of GTP by G alpha t-GTP and RGS in cytosol
xref_analog: IMR:0000431
xref_analog: IMR:0001354
is_a: IEV:0000672 ! Hydrolysis of GTP by G alpha-GTP in cytosol
relationship: part_of IEV:0000735 ! G alpha t-GTP hydrolysis signaling
relationship: part_of IEV:0002063 ! Negative regulation of (GDP-GTP exchange of G alpha t)

[Term]
id: IEV:0000739
name: Ion transport through ion channel
def: "The directed movement of charged atoms or small charged molecules into, out of, within or between cells." [GO:0006811]
exact_synonym: "ion transport" []
xref_analog: GO:0006811
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000740
name: Cation ion transport from extracellular to cytosol through cation channel
xref_analog: IMR:0000498
xref_analog: IMR:0001658
is_a: IEV:0000733 ! Negative regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)
is_a: IEV:0000739 ! Ion transport through ion channel
is_a: IEV:0001943 ! Translocation from ER to cytosol
relationship: part_of IEV:0000759 ! Rhodopsin dark adaptation signaling

[Term]
id: IEV:0000741
name: GDP-GTP exchange of G alpha q in cytosol
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: IMR:0100378
xref_analog: PubMed:14734786
is_a: IEV:0000663 ! GDP-GTP exchange of G alpha in cytosol
relationship: part_of IEV:0002031 ! G alpha q GDP-GTP exchange signaling
relationship: part_of IEV:0002037 ! Negative regulation of (Hydrolysis of GTP by G alpha q-GTP and RGS)

[Term]
id: IEV:0000742
name: Visual perception
def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GO:0007601]
xref_analog: GO:0007601
is_a: IEV:0000744 ! Neurological system process

[Term]
id: IEV:0000743
name: Changes in polarization state of photoreceptor cell membrane
is_a: IEV:0001239 ! Changes in polarization state of the membrane

[Term]
id: IEV:0000744
name: Neurological system process
def: "The processes pertaining to the functions of the nervous system of an organism." [GO:0050877]
exact_synonym: "Neurological process" []
exact_synonym: "Neurophysiological process" [GO:0050877]
xref_analog: GO:0050877
is_a: IEV:0001327 ! Multicellular organismal process

[Term]
id: IEV:0000745
name: Neurotransmitter secretion
def: "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [GO:0007269]
exact_synonym: "neurotransmitter release" []
xref_analog: GO:0007269
is_a: IEV:0003806 ! Neurotransmitter transport
relationship: part_of IEV:0000744 ! Neurological system process

[Term]
id: IEV:0000746
name: Adaptation of rhodopsin mediated signaling
def: "Process by which the visual system can modulate its sensitivity and response to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation." [GO:0016062]
xref_analog: GO:0016062
relationship: part_of IEV:0000742 ! Visual perception

[Term]
id: IEV:0000747
name: Deactivation of rhodopsin mediated signaling
def: "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [GO:0016059]
xref_analog: GO:0016059
relationship: part_of IEV:0000742 ! Visual perception

[Term]
id: IEV:0000748
name: Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
xref_analog: GO:0007200
is_a: IEV:0002634 ! Heterotrimeric GPCR signaling pathway (through G alpha q)

[Term]
id: IEV:0000749
name: Dissociation of G alpha q-GTP and G beta:G gamma in cytosol
xref_analog: GO:0007201
xref_analog: IMR:0001354
xref_analog: IMR:0100018
xref_analog: IMR:0100378
is_a: IEV:0000664 ! Dissociation of G alpha-GTP and G beta:G gamma in cytosol
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)

[Term]
id: IEV:0000750
name: Binding of G alpha q-GTP and PLC beta in cytosol
xref_analog: IMR:0000286
xref_analog: IMR:0001354
xref_analog: IMR:0100378
xref_analog: PubMed:14734786
is_a: IEV:0002403 ! Binding of G alpha q-GTP and PLC in cytosol
relationship: part_of IEV:0000065 ! PLC beta signaling

[Term]
id: IEV:0000751
name: Regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
is_a: IEV:0000668 ! Regulation of heterotrimeric GPCR signaling pathway
relationship: regulates IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)

[Term]
id: IEV:0000752
name: Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
is_a: IEV:0000669 ! Negative regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000751 ! Regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
relationship: negatively_regulates IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)

[Term]
id: IEV:0000753
name: Positive regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
is_a: IEV:0000670 ! Positive regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000751 ! Regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
relationship: positively_regulates IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)

[Term]
id: IEV:0000754
name: G alpha q-GTP hydrolysis signaling
is_a: IEV:0000671 ! G alpha-GTP hydrolysis signaling
is_a: IEV:0000752 ! Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)

[Term]
id: IEV:0000755
name: Binding of G alpha q-GTP and RGS in cytosol
xref_analog: IMR:0000431
xref_analog: IMR:0001354
xref_analog: IMR:0100378
is_a: IEV:0000674 ! Binding of G alpha-GTP and RGS in cytosol
is_a: IEV:0002016 ! Binding of G alpha q-GTP and effector in cytosol
relationship: part_of IEV:0000754 ! G alpha q-GTP hydrolysis signaling

[Term]
id: IEV:0000756
name: Dissociation of G alpha q-GDP and PLC beta in cytosol
xref_analog: IMR:0000286
xref_analog: IMR:0001357
xref_analog: IMR:0100378
is_a: IEV:0000675 ! Dissociation of G alpha-GDP and target protein in cytosol
relationship: part_of IEV:0000754 ! G alpha q-GTP hydrolysis signaling

[Term]
id: IEV:0000757
name: Hydrolysis of GTP by G alpha q-GTP and RGS in cytosol
xref_analog: IMR:0000431
xref_analog: IMR:0001354
xref_analog: IMR:0100378
is_a: IEV:0000672 ! Hydrolysis of GTP by G alpha-GTP in cytosol
relationship: part_of IEV:0000754 ! G alpha q-GTP hydrolysis signaling
relationship: part_of IEV:0002061 ! Negative regulation of (GDP-GTP exchange of G alpha q)

[Term]
id: IEV:0000758
name: Rhodopsin dark adaptation
is_a: IEV:0000744 ! Neurological system process

[Term]
id: IEV:0000759
name: Rhodopsin dark adaptation signaling
is_a: IEV:0000121 ! Rhodopsin mediated signaling pathway
relationship: part_of IEV:0000758 ! Rhodopsin dark adaptation

[Term]
id: IEV:0000760
name: Inactivation of Rhodopsin in extracellular
xref_analog: UniProt:P08100
is_a: IEV:0000245 ! Inactivation in extracellular
relationship: part_of IEV:0000759 ! Rhodopsin dark adaptation signaling

[Term]
id: IEV:0000761
name: Nuclear import of Notch (NIC) from the cytosol
xref_analog: IMR:0100712
xref_analog: PubMed:14985712
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001171 ! Nuclear import of Notch (NIC) from the plasma membrane

[Term]
id: IEV:0000762
name: Channel opening/closing in the plasma membrane
is_a: IEV:0000767 ! Channel opening/closing

[Term]
id: IEV:0000763
name: Binding of cGMP and cGMP activated cation ion channel and the channel opening in cytosol
xref_analog: IMR:0100003
xref_analog: IMR:0100025
is_a: IEV:0000013 ! Binding in cytosol
is_a: IEV:0000762 ! Channel opening/closing in the plasma membrane
relationship: part_of IEV:0000759 ! Rhodopsin dark adaptation signaling

[Term]
id: IEV:0000764
name: Dissociation of cGMP and cGMP activated cation ion channel and the channel closing in cytosol
xref_analog: IMR:0100003
xref_analog: IMR:0100025
is_a: IEV:0000023 ! Dissociation in cytosol
is_a: IEV:0000762 ! Channel opening/closing in the plasma membrane
relationship: part_of IEV:0001249 ! Cytosolic cation ion concentration decline (through cGMP activated cation ion channel)

[Term]
id: IEV:0000765
name: Dissociation of IP3 and IP3R and IP3R closing
xref_analog: IMR:0000084
xref_analog: IMR:0100028
is_a: IEV:0000770 ! Channel opening/closing in the ER membrane
is_a: IEV:0001032 ! Dissociation outside the ER membrane

[Term]
id: IEV:0000766
name: Binding of G alpha t-GDP and G beta:G gamma in cytosol
xref_analog: IMR:0000321
xref_analog: IMR:0001357
xref_analog: IMR:0100018
is_a: IEV:0001981 ! Binding of G alpha-GDP and G beta:G gamma in cytosol
relationship: part_of IEV:0000759 ! Rhodopsin dark adaptation signaling

[Term]
id: IEV:0000767
name: Channel opening/closing
is_a: IEV:0000071 ! Molecular event

[Term]
id: IEV:0000768
name: Hyper polarization state of photoreceptor cell membrane
is_a: IEV:0000743 ! Changes in polarization state of photoreceptor cell membrane
relationship: part_of IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)

[Term]
id: IEV:0000769
name: Depolarization state of photoreceptor cell membrane
is_a: IEV:0000743 ! Changes in polarization state of photoreceptor cell membrane
relationship: part_of IEV:0000759 ! Rhodopsin dark adaptation signaling

[Term]
id: IEV:0000770
name: Channel opening/closing in the ER membrane
is_a: IEV:0000767 ! Channel opening/closing

[Term]
id: IEV:0000771
name: Change in material concentration
is_a: IEV:0000071 ! Molecular event

[Term]
id: IEV:0000772
name: Cytosolic calcium ion concentration elevation (through IP3 receptor)
def: "Any process that increases the concentration of calcium ions in the cytosol during the process of G-protein signaling coupled to IP3 second messenger." [GO:0051482]
exact_synonym: "elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" []
exact_synonym: "elevation of cytosolic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" []
xref_analog: GO:0051482
is_a: IEV:0001246 ! Cytosolic calcium ion concentration elevation
relationship: part_of IEV:0000065 ! PLC beta signaling
relationship: part_of IEV:0000467 ! PLC gamma signaling
relationship: part_of IEV:0000471 ! PLC signaling
relationship: part_of IEV:0000759 ! Rhodopsin dark adaptation signaling
relationship: part_of IEV:0002632 ! VEGF receptor signaling pathway

[Term]
id: IEV:0000773
name: Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o and PLCbeta)
is_a: IEV:0002635 ! Heterotrimeric GPCR signaling pathway (through G alpha o)

[Term]
id: IEV:0000774
name: Circadian rhythm
alt_id: IEV:0001334
def: "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GO:0007623]
exact_synonym: "Response to circadian rhythm" []
exact_synonym: "Circadian process" []
xref_analog: GO:0007623
xref_analog: KEGG:hsa04710
xref_analog: KEGG:mmu04710
xref_analog: KEGG:rno04710
is_a: IEV:0003807 ! Rhythmic process

[Term]
id: IEV:0000775
name: Binding of melatonin and melatonin receptor in cytosol
comment: part_of: Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o, PLCbeta and circadian rhythm)
xref_analog: GO:0001664
xref_analog: GO:0008502
xref_analog: IMR:0100069
xref_analog: UniProt:P48039
xref_analog: UniProt:P49286
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000773 ! Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o and PLCbeta)

[Term]
id: IEV:0000776
name: GDP-GTP exchange of G alpha o in cytosol
xref_analog: IMR:0000320
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: PubMed:14734786
is_a: IEV:0000663 ! GDP-GTP exchange of G alpha in cytosol
relationship: part_of IEV:0000773 ! Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o and PLCbeta)

[Term]
id: IEV:0000777
name: Dissociation of G alpha o-GTP and G beta:G gamma in cytosol
xref_analog: IMR:0000320
xref_analog: IMR:0001354
xref_analog: IMR:0100018
is_a: IEV:0000664 ! Dissociation of G alpha-GTP and G beta:G gamma in cytosol
relationship: part_of IEV:0000773 ! Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o and PLCbeta)

[Term]
id: IEV:0000778
name: Binding of G alpha o-GTP and PLC beta in cytosol
xref_analog: IMR:0000286
xref_analog: IMR:0000320
xref_analog: IMR:0001354
xref_analog: PubMed:14734786
is_a: IEV:0001998 ! Binding of G alpha o-GTP and effector in cytosol

[Term]
id: IEV:0000779
name: PKC activation signaling
def: "The series of molecular signals that results in the upregulation of protein kinase C activity in response to the signal." [GO:0007205]
exact_synonym: "PKC activation" [GO:0007205]
exact_synonym: "protein kinase C activation" [GO:0007205]
xref_analog: GO:0007205
is_a: IEV:0000458 ! Protein activation/inactivation signaling
is_a: IEV:0001302 ! Calcium ion dependent protein activation signaling
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
relationship: part_of IEV:0000773 ! Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o and PLCbeta)
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0002633 ! Heterotrimeric GPCR signaling pathway (through Angiotensin and G alpha q)
relationship: part_of IEV:0002653 ! Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)

[Term]
id: IEV:0000780
name: PKA activation signaling
xref_analog: PubMed:14734786
is_a: IEV:0000458 ! Protein activation/inactivation signaling
is_a: IEV:0001988 ! cAMP mediated signaling
relationship: part_of IEV:0000055 ! PKA-Bad signaling
relationship: part_of IEV:0000276 ! Heterotrimeric GPCR signaling pathway (through PACAP, G alpha s and adenylate cyclase, cAMP and PKA)
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)
relationship: part_of IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
relationship: part_of IEV:0002637 ! Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)

[Term]
id: IEV:0000782
name: Phosphorylation of IKK complex by MEKK3 in cytosol
def: "TNFR1 signaling" [XX:<new dbxref>]
xref_analog: GO:0007250
xref_analog: IMR:0000243
xref_analog: IMR:0100451
is_a: IEV:0000250 ! Phosphorylation of IKK complex by MAPKKK in cytosol

[Term]
id: IEV:0000783
name: Gene expression by NF-kappaB
xref_analog: IMR:0000382
is_a: IEV:0000233 ! Gene expression by transcriptional regulator
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000784
name: Phosphorylation of IKK complex by TAK1 in cytosol
def: "Toll-like receptor pathway" [XX:<new dbxref>]
narrow_synonym: "Phosphorylation of DmIKK by TAK1 [Drosophila]" []
xref_analog: IMR:0000232
xref_analog: IMR:0000243
xref_analog: PubMed:15125833
is_a: IEV:0000250 ! Phosphorylation of IKK complex by MAPKKK in cytosol
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)
relationship: part_of IEV:0003456 ! IMD signaling pathway

[Term]
id: IEV:0000785
name: Regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
is_a: IEV:0001400 ! Regulation of Toll-like receptor pathway
relationship: regulates IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000786
name: Negative regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
is_a: IEV:0000785 ! Regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
is_a: IEV:0001673 ! Negative regulation of Toll-like receptor pathway
relationship: negatively_regulates IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000787
name: Positive regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK- NF-kappaB cascade)
is_a: IEV:0000785 ! Regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
is_a: IEV:0001674 ! Positive regulation of Toll-like receptor pathway
relationship: positively_regulates IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000788
name: Binding of RelA and PPAR in inner space of nucleus
xref_analog: IMR:0000089
xref_analog: IMR:0100446
xref_analog: PubMed:14587029
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000786 ! Negative regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000789
name: PPAR signaling
exact_synonym: "peroxisome proliferator-activated receptor signaling" []
xref_analog: KEGG:hsa03320
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0000790
name: Binding of ligand and PPAR in cytosol
xref_analog: IMR:0000002
xref_analog: IMR:0000089
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000789 ! PPAR signaling

[Term]
id: IEV:0000791
name: Binding outside the nuclear membrane
is_a: IEV:0000013 ! Binding in cytosol
is_a: IEV:0000017 ! Binding in nuclear membrane

[Term]
id: IEV:0000792
name: Binding of PPAR and nuclear receptor in inner space of nucleus
xref_analog: IMR:0000085
xref_analog: IMR:0000089
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000789 ! PPAR signaling

[Term]
id: IEV:0000793
name: Binding of PPAR and PPRE in inner space of nucleus
xref_analog: IGS:0000015
xref_analog: IMR:0000089
is_a: IEV:0002098 ! Binding of transcription factor and responsive element in inner space of nucleus
relationship: part_of IEV:0000789 ! PPAR signaling

[Term]
id: IEV:0000794
name: Binding of fatty acid and PPAR in cytosol
xref_analog: IMR:0000089
xref_analog: KEGG:C00162
is_a: IEV:0000790 ! Binding of ligand and PPAR in cytosol

[Term]
id: IEV:0000795
name: Binding of PPAR and transcription factor in inner space of nucleus
xref_analog: IMR:0000089
xref_analog: IMR:0000368
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000789 ! PPAR signaling

[Term]
id: IEV:0000796
name: Binding of PPAR and RXR in inner space of nucleus
xref_analog: IMR:0000089
xref_analog: UniProt:P19793
xref_analog: UniProt:P28702
is_a: IEV:0000792 ! Binding of PPAR and nuclear receptor in inner space of nucleus

[Term]
id: IEV:0000797
name: Phosphorylation of PPAR by kinase in cytosol
xref_analog: IMR:0000089
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000789 ! PPAR signaling

[Term]
id: IEV:0000798
name: Regulation of PPAR signaling
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000789 ! PPAR signaling

[Term]
id: IEV:0000799
name: Negative regulation of PPAR signaling
is_a: IEV:0000798 ! Regulation of PPAR signaling
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0000789 ! PPAR signaling

[Term]
id: IEV:0000800
name: Positive regulation of PPAR signaling
is_a: IEV:0000798 ! Regulation of PPAR signaling
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0000789 ! PPAR signaling

[Term]
id: IEV:0000801
name: Dephosphorylation of PPAR by phosphatase in cytosol
xref_analog: IMR:0000089
xref_analog: IMR:0000517
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0000799 ! Negative regulation of PPAR signaling

[Term]
id: IEV:0000802
name: TNFR2 signaling pathway (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0002409 ! TNFR2 signaling pathway

[Term]
id: IEV:0000803
name: Trimerization of TNFR2 in plasma membrane
exact_synonym: "TNFR2 trimerization" []
xref_analog: IMR:0000061
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000804
name: Binding of TNF alpha homotrimer and TNFR2 in extracellular
xref_analog: IMR:0000025
xref_analog: IMR:0000061
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000805
name: Binding of TNFR2 and TRAF2 in cytosol
xref_analog: IMR:0000061
xref_analog: IMR:0100423
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000806
name: Binding of TNFR2 and TRAF1 in cytosol
xref_analog: IMR:0000061
xref_analog: IMR:0100422
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000807
name: Activation of MEKK1 by RIP in cytosol
xref_analog: IMR:0000269
xref_analog: IMR:0100222
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000808
name: Activation of NIK by RIP in cytosol
xref_analog: IMR:0000242
xref_analog: IMR:0000269
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000809
name: Phosphorylation of MEKK1 by NIK in cytosol
xref_analog: IMR:0000242
xref_analog: IMR:0100222
is_a: IEV:0000633 ! Phosphorylation of MAPKKK by MAPKKKK in cytosol
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000810
name: Phosphorylation of IKK complex by MEKK1 in cytosol
xref_analog: GO:0007250
xref_analog: IMR:0000243
xref_analog: IMR:0100222
is_a: IEV:0000250 ! Phosphorylation of IKK complex by MAPKKK in cytosol

[Term]
id: IEV:0000811
name: Phosphorylation of MKK4/7 by ASK1 in cytosol
def: "TNFR1 signaling" [XX:<new dbxref>]
xref_analog: GO:0007256
xref_analog: IMR:0000262
xref_analog: IMR:0100218
is_a: IEV:0000227 ! Phosphorylation of MKK4/7 by MAPKKK in cytosol
relationship: part_of IEV:0000161 ! Fas signaling pathway (through caspase cascade)

[Term]
id: IEV:0000812
name: Binding of PDGF and PDGF receptor in extracellular
xref_analog: IMR:0000032
xref_analog: IMR:0000068
is_a: IEV:0000842 ! Binding of RTK-ligand and RTK in extracellular
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
relationship: part_of IEV:0001257 ! PDGF receptor signaling pathway

[Term]
id: IEV:0000813
name: Dimerization of PDGF receptor in plasma membrane
exact_synonym: "PDGF receptor dimerization" []
xref_analog: IMR:0000068
is_a: IEV:0000846 ! Dimerization of RTK in plasma membrane
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
relationship: part_of IEV:0001257 ! PDGF receptor signaling pathway

[Term]
id: IEV:0000814
name: Autophosphorylation of PDGF receptor in plasma membrane
xref_analog: IMR:0000068
is_a: IEV:0000843 ! Autophosphorylation of RTK in plasma membrane
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
relationship: part_of IEV:0001257 ! PDGF receptor signaling pathway

[Term]
id: IEV:0000815
name: Binding of PDGF receptor and Grb2 in cytosol
alt_id: IEV:0002452
exact_synonym: "Binding of (PDGF:PDGF Receptor_p) and (GRB2:SOS)" []
xref_analog: IMR:0000068
xref_analog: IMR:0000340
is_a: IEV:0000844 ! Binding of RTK and Grb2 in cytosol
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
relationship: part_of IEV:0001257 ! PDGF receptor signaling pathway

[Term]
id: IEV:0000816
name: Binding of PDGF receptor and Shc in cytosol
xref_analog: IMR:0000068
xref_analog: IMR:0000347
is_a: IEV:0000845 ! Binding of RTK and Shc in cytosol
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
relationship: part_of IEV:0001257 ! PDGF receptor signaling pathway

[Term]
id: IEV:0000817
name: Transcription of c-fos by Elk-1 in nucleus
xref_analog: IMR:0000813
xref_analog: IMR:0001094
is_a: IEV:0003549 ! Transcription in nucleus
relationship: part_of IEV:0003700 ! Gene expression by Elk-1

[Term]
id: IEV:0000818
name: Metabolic pathway
is_a: IEV:0000001 ! Pathway

[Term]
id: IEV:0000819
name: Phosphorylation of Elk-1 by ERK_p in inner space of nucleus
def: "PDGF signaling" [XX:<new dbxref>]
xref_analog: IMR:0000227
xref_analog: IMR:0001094
is_a: IEV:0003869 ! Phosphorylation of ets domain transcription factor  by ERK_p in inner space of nucleus

[Term]
id: IEV:0000820
name: Phosphorylation of MEK1/2(MKK1/2) by Raf in cytosol
def: "PDGF signaling, Integrin signaling, G" [XX:<new dbxref>]
xref_analog: IMR:0000231
xref_analog: IMR:0000261
xref_analog: PubMed:11752597
is_a: IEV:0000475 ! Phosphorylation of MEK1/2(MKK1/2) by MAPKKK in cytosol

[Term]
id: IEV:0000821
name: Regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
is_a: IEV:0001406 ! Regulation of PDGF signaling pathway
relationship: regulates IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)

[Term]
id: IEV:0000822
name: Negative regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
is_a: IEV:0000821 ! Regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
is_a: IEV:0001671 ! Negative regulation of PDGF receptor signaling pathway
relationship: negatively_regulates IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)

[Term]
id: IEV:0000823
name: Positive regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
is_a: IEV:0000821 ! Regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
is_a: IEV:0001672 ! Positive regulation of PDGF signaling pathway
relationship: positively_regulates IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)

[Term]
id: IEV:0000824
name: Dissociation of Ras-GDP and target protein in cytosol
xref_analog: IMR:0000290
xref_analog: IMR:0001357
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000703 ! Ras-GTP hydrolysis signaling

[Term]
id: IEV:0000825
name: PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0001257 ! PDGF receptor signaling pathway

[Term]
id: IEV:0000826
name: RalGDS-Ral-RalBP1 signaling
is_a: IEV:0001263 ! Ral mediated signaling
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)

[Term]
id: IEV:0000827
name: Binding of Ras-GTP and RalGDS in cytosol
xref_analog: IMR:0000290
xref_analog: IMR:0001354
xref_analog: IMR:0100433
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000826 ! RalGDS-Ral-RalBP1 signaling
relationship: part_of IEV:0000857 ! RalGDS-Ral-PLD1 signaling

[Term]
id: IEV:0000828
name: GDP-GTP exchange of Ral by RalGDS in cytosol
xref_analog: IMR:0000293
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: IMR:0100433
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0000826 ! RalGDS-Ral-RalBP1 signaling
relationship: part_of IEV:0000857 ! RalGDS-Ral-PLD1 signaling

[Term]
id: IEV:0000829
name: Binding of Ral-GTP and RalBP1 in cytosol
def: "Activation of RalBP1 by Ral-GTP" [XX:<new dbxref>]
xref_analog: IMR:0000293
xref_analog: IMR:0001354
xref_analog: UniProt:Q15311
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000826 ! RalGDS-Ral-RalBP1 signaling

[Term]
id: IEV:0000830
name: RTK signaling pathway
def: "The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand." [GO:0007169]
exact_synonym: "transmembrane receptor protein tyrosine kinase signaling pathway" []
xref_analog: GO:0007169
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0000831
name: Complex formation of PI3K, Eps8, Abi1 and Sos1 in cytosol
xref_analog: IMR:0000265
xref_analog: IMR:0002063
xref_analog: PubMed:12515821
xref_analog: UniProt:Q12929
xref_analog: UniProt:Q8IZP0
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000833 ! Rac activation signaling (through PI3K)

[Term]
id: IEV:0000832
name: GDP-GTP exchange of Rac by Sos1 in cytosol
xref_analog: IMR:0000297
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: IMR:0002063
xref_analog: PubMed:12515821
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0000833 ! Rac activation signaling (through PI3K)

[Term]
id: IEV:0000833
name: Rac activation signaling (through PI3K)
xref_analog: PubMed:12515821
is_a: IEV:0001300 ! Rac activation signaling
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000834
name: Regulation of RTK signaling pathway
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000830 ! RTK signaling pathway

[Term]
id: IEV:0000835
name: Negative regulation of RTK signaling pathway
is_a: IEV:0000834 ! Regulation of RTK signaling pathway
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0000830 ! RTK signaling pathway

[Term]
id: IEV:0000836
name: Positive regulation of RTK signaling pathway
is_a: IEV:0000834 ! Regulation of RTK signaling pathway
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0000830 ! RTK signaling pathway

[Term]
id: IEV:0000837
name: Activation of NF-kappaB by Rac-GTP in cytosol
exact_synonym: "NF-kappaB activation" []
xref_analog: IMR:0000297
xref_analog: IMR:0000382
xref_analog: IMR:0001354
xref_analog: PubMed:10740269
is_a: IEV:0003859 ! Activation of NF-kappaB in cytosol
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000838
name: Gene expression of anti-apoptotic gene by NF-kappaB
xref_analog: IMR:0000382
is_a: IEV:0000783 ! Gene expression by NF-kappaB
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000839
name: Regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
is_a: IEV:0001406 ! Regulation of PDGF signaling pathway
relationship: regulates IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000840
name: Negative regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
is_a: IEV:0000839 ! Regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
is_a: IEV:0001671 ! Negative regulation of PDGF receptor signaling pathway
relationship: negatively_regulates IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000841
name: Positive regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
is_a: IEV:0000839 ! Regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
is_a: IEV:0001672 ! Positive regulation of PDGF signaling pathway
relationship: positively_regulates IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000842
name: Binding of RTK-ligand and RTK in extracellular
xref_analog: IMR:0000030
xref_analog: IMR:0000063
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000843
name: Autophosphorylation of RTK in plasma membrane
xref_analog: GO:0004714
xref_analog: IMR:0000063
is_a: IEV:0000486 ! Autophosphorylation in plasma membrane
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000844
name: Binding of RTK and Grb2 in cytosol
xref_analog: IMR:0000063
xref_analog: IMR:0000340
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000845
name: Binding of RTK and Shc in cytosol
xref_analog: IMR:0000063
xref_analog: IMR:0000347
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000846
name: Dimerization of RTK in plasma membrane
exact_synonym: "RTK dimerization" []
exact_synonym: "transmembrane receptor protein tyrosine kinase activation (dimerization)" []
xref_analog: GO:0007171
xref_analog: IMR:0000063
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000847
name: RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: part_of IEV:0000830 ! RTK signaling pathway

[Term]
id: IEV:0000848
name: RalGDS activation signaling (through Grb2 and Sos)
exact_synonym: "Grb2-Sos-Ras-RalGDS signaling" []
is_a: IEV:0000458 ! Protein activation/inactivation signaling
is_a: IEV:0001258 ! Ras mediated signaling
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000849
name: Activation of RalGDS by Ras-GTP in cytosol
xref_analog: IMR:0000290
xref_analog: IMR:0001354
xref_analog: IMR:0100433
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000848 ! RalGDS activation signaling (through Grb2 and Sos)

[Term]
id: IEV:0000850
name: Rac-GTP hydrolysis signaling
is_a: IEV:0000684 ! Small GTPase hydrolysis signaling
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)

[Term]
id: IEV:0000851
name: Hydrolysis of GTP by Rac in cytosol
xref_analog: IMR:0000297
xref_analog: IMR:0001354
is_a: IEV:0000680 ! Hydrolysis of GTP by small GTPase in cytosol
relationship: part_of IEV:0000850 ! Rac-GTP hydrolysis signaling

[Term]
id: IEV:0000852
name: Dissociation of Rac-GDP and target protein in cytosol
xref_analog: IMR:0000297
xref_analog: IMR:0001357
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000850 ! Rac-GTP hydrolysis signaling

[Term]
id: IEV:0000853
name: Regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
is_a: IEV:0000834 ! Regulation of RTK signaling pathway
relationship: regulates IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)

[Term]
id: IEV:0000854
name: Negative regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
is_a: IEV:0000835 ! Negative regulation of RTK signaling pathway
is_a: IEV:0000853 ! Regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: negatively_regulates IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)

[Term]
id: IEV:0000855
name: Positive regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
is_a: IEV:0000836 ! Positive regulation of RTK signaling pathway
is_a: IEV:0000853 ! Regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: positively_regulates IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)

[Term]
id: IEV:0000856
name: RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
relationship: part_of IEV:0000830 ! RTK signaling pathway

[Term]
id: IEV:0000857
name: RalGDS-Ral-PLD1 signaling
is_a: IEV:0001263 ! Ral mediated signaling
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000858
name: Binding of Ral-GTP and Phospholipase D1 in cytosol
xref_analog: IMR:0000293
xref_analog: IMR:0000728
xref_analog: IMR:0001354
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000857 ! RalGDS-Ral-PLD1 signaling

[Term]
id: IEV:0000859
name: Hydrolysis of phosphatidic acid by PLD1 in cytosol
xref_analog: IMR:0000728
xref_analog: KEGG:C00416
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000860
name: Regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
is_a: IEV:0000834 ! Regulation of RTK signaling pathway
relationship: regulates IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000861
name: Negative regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
is_a: IEV:0000835 ! Negative regulation of RTK signaling pathway
is_a: IEV:0000860 ! Regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
relationship: negatively_regulates IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000862
name: Positive regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
is_a: IEV:0000836 ! Positive regulation of RTK signaling pathway
is_a: IEV:0000860 ! Regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
relationship: positively_regulates IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000863
name: BMP signaling pathway
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor." [GO:0030509]
exact_synonym: "BMP receptor signaling pathway" [GO:0030509]
xref_analog: GO:0030509
is_a: IEV:0000090 ! TGF beta super family signaling pathway
relationship: part_of IEV:0003881 ! Amnioserosa formation
relationship: part_of IEV:0003882 ! Ectoderm formation

[Term]
id: IEV:0000864
name: TGF beta signaling pathway
def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands." [GO:0007179]
exact_synonym: "transforming growth factor beta receptor signaling pathway" [GO:0007179]
xref_analog: GO:0007179
xref_analog: KEGG:hsa04350
is_a: IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000865
name: EGF receptor signaling pathway
def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands." [GO:0007173]
exact_synonym: "EGF signaling pathway" [GO:0007173]
exact_synonym: "EGFR signaling pathway" [GO:0007173]
exact_synonym: "epidermal growth factor receptor signaling pathway" [GO:0007173]
xref_analog: GO:0007173
is_a: IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0003744 ! Vulval development
relationship: part_of IEV:0003749 ! Ovulation

[Term]
id: IEV:0000866
name: NGF receptor signaling pathway
def: "The series of molecular signals generated as a consequence of the nerve growth factor receptor binding to one of its physiological ligands." [GO:0048011]
exact_synonym: "nerve growth factor receptor signaling pathway" [GO:0048011]
exact_synonym: "NGF signaling pathway" [GO:0048011]
xref_analog: GO:0048011
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000867
name: EPO signaling pathway
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000868
name: p53 degradation signaling
xref_analog: PubMed:10721693
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
relationship: part_of IEV:0001108 ! Negative feedback regulation of p53 signaling pathway by Mdm2

[Term]
id: IEV:0000869
name: Ubiquitination of p53 by Mdm2 in nucleus
xref_analog: IMR:0100659
xref_analog: IMR:0100660
xref_analog: PubMed:10721693
xref_analog: PubMed:15021897
is_a: IEV:0001932 ! Ubiquitination of p53 by ubiquitin ligase in nucleus
relationship: part_of IEV:0000868 ! p53 degradation signaling

[Term]
id: IEV:0000870
name: Binding of Mdm2 and p19ARF in inner space of nucleus
xref_analog: IMR:0100660
xref_analog: IMR:0701010
xref_analog: PubMed:15021897
is_a: IEV:0001934 ! Binding of Mdm2 and ARF in inner space of nucleus
relationship: part_of IEV:0000165 ! p53 signaling pathway (through p21)
relationship: part_of IEV:0001107 ! p53 signaling pathway (through GADD45)
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0000871
name: Ubiquitination in nucleus
is_a: IEV:0000012 ! Ubiquitination

[Term]
id: IEV:0000872
name: DNA repair
def: "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [GO:0006281]
xref_analog: GO:0006281
xref_analog: MeSH:D004260
is_a: IEV:0000071 ! Molecular event

[Term]
id: IEV:0000873
name: Regulation of TGF beta signaling pathway
def: "Any process that modulates the frequency, rate or extent of activity of any TGFbeta receptor signaling pathway." [GO:0017015]
xref_analog: GO:0017015
is_a: IEV:0000876 ! Regulation of TGF beta super family signaling pathway (through p38 cascade)
relationship: regulates IEV:0000864 ! TGF beta signaling pathway

[Term]
id: IEV:0000874
name: Negative regulation of TGF beta signaling pathway
def: "Any process that stops, prevents or reduces the rate, frequency or extent of any TGFbeta receptor signaling pathway." [GO:0030512]
xref_analog: GO:0030512
is_a: IEV:0000873 ! Regulation of TGF beta signaling pathway
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0000864 ! TGF beta signaling pathway

[Term]
id: IEV:0000875
name: Positive regulation of TGF beta signaling pathway
def: "Any process that activates or increases the rate, frequency or extent of TGFbeta receptor signaling pathway activity." [GO:0030511]
xref_analog: GO:0030511
is_a: IEV:0000873 ! Regulation of TGF beta signaling pathway
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0000864 ! TGF beta signaling pathway

[Term]
id: IEV:0000876
name: Regulation of TGF beta super family signaling pathway (through p38 cascade)
is_a: IEV:0000879 ! Regulation of TGF beta super family signaling pathway
relationship: regulates IEV:0000059 ! TGF beta super family signaling pathway (through p38 cascade)

[Term]
id: IEV:0000877
name: Negative regulation of TGF beta super family signaling pathway (through p38 cascade)
is_a: IEV:0000876 ! Regulation of TGF beta super family signaling pathway (through p38 cascade)
is_a: IEV:0000880 ! Negative regulation of TGF beta super family signaling pathway
relationship: negatively_regulates IEV:0000059 ! TGF beta super family signaling pathway (through p38 cascade)

[Term]
id: IEV:0000878
name: Positive regulation of TGF beta super family signaling pathway (through p38 cascade)
is_a: IEV:0000876 ! Regulation of TGF beta super family signaling pathway (through p38 cascade)
is_a: IEV:0000881 ! Positive regulation of TGF beta super family signaling pathway
relationship: positively_regulates IEV:0000059 ! TGF beta super family signaling pathway (through p38 cascade)

[Term]
id: IEV:0000879
name: Regulation of TGF beta super family signaling pathway
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000880
name: Negative regulation of TGF beta super family signaling pathway
is_a: IEV:0000879 ! Regulation of TGF beta super family signaling pathway
relationship: negatively_regulates IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000881
name: Positive regulation of TGF beta super family signaling pathway
is_a: IEV:0000879 ! Regulation of TGF beta super family signaling pathway
relationship: positively_regulates IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000882
name: Regulation of BMP signaling pathway
def: "Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GO:0030510]
xref_analog: GO:0030510
is_a: IEV:0000876 ! Regulation of TGF beta super family signaling pathway (through p38 cascade)
relationship: regulates IEV:0000863 ! BMP signaling pathway

[Term]
id: IEV:0000883
name: Negative regulation of BMP signaling pathway
def: "Any process that stops, prevents or reduces the rate, frequency or extent of BMP signaling pathway activity." [GO:0030514]
xref_analog: GO:0030514
is_a: IEV:0000880 ! Negative regulation of TGF beta super family signaling pathway
is_a: IEV:0000882 ! Regulation of BMP signaling pathway
relationship: negatively_regulates IEV:0000863 ! BMP signaling pathway

[Term]
id: IEV:0000884
name: Positive regulation of BMP signaling pathway
def: "Any process that activates or increases the rate, frequency or extent of BMP signaling pathway activity." [GO:0030513]
xref_analog: GO:0030513
is_a: IEV:0000881 ! Positive regulation of TGF beta super family signaling pathway
is_a: IEV:0000882 ! Regulation of BMP signaling pathway
relationship: positively_regulates IEV:0000863 ! BMP signaling pathway

[Term]
id: IEV:0000885
name: Negative feedback regulation pathway of TGF beta superfamily signaling
exact_synonym: "Negative feedback regulation pathway of TGF beta superfamily signaling pathway" []
is_a: IEV:0000880 ! Negative regulation of TGF beta super family signaling pathway

[Term]
id: IEV:0000886
name: Gene expression of I-Smad by R-Smad:Smad4
exact_synonym: "Gene expression of Smad6/7 by R-Smad:Smad4" []
xref_analog: IMR:0000371
xref_analog: IMR:0000373
xref_analog: IMR:0100315
is_a: IEV:0001142 ! Gene expression by Smad complex
relationship: part_of IEV:0000903 ! Negative feedback regulation pathway of TGF beta superfamily signaling by (binding of I-Smad and TGF beta receptor I)

[Term]
id: IEV:0000887
name: Binding of I-Smad and TGF beta receptor I in cytosol
exact_synonym: "Binding of Smad6/7 and TGF beta receptor I in cytosol" []
xref_analog: IMR:0000373
xref_analog: IMR:0000710
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000903 ! Negative feedback regulation pathway of TGF beta superfamily signaling by (binding of I-Smad and TGF beta receptor I)

[Term]
id: IEV:0000888
name: Phosphorylation of R-Smad:Smad4 by MAPK in cytosol
xref_analog: IMR:0000224
xref_analog: IMR:0000371
xref_analog: IMR:0100315
xref_analog: PubMed:11752591
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001846 ! Negative regulation of (nuclear import of R-Smad:Smad4) in TGF beta super family signaling pathway

[Term]
id: IEV:0000889
name: TGF beta receptor I degradation signaling
xref_analog: PubMed:11163210
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
relationship: part_of IEV:0000905 ! Negative feedback regulation pathway of TGF beta superfamily signaling by (TGF receptor degradation by smurf)

[Term]
id: IEV:0000890
name: Complex formation of Smad7 and smurf2 in cytosol
xref_analog: IMR:0100318
xref_analog: IMR:0100514
xref_analog: PubMed:11163210
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000889 ! TGF beta receptor I degradation signaling
relationship: part_of IEV:0000895 ! R-Smad degradation signaling

[Term]
id: IEV:0000891
name: Binding of Smad7:smurf2 and TGF beta type I receptor in cytosol
xref_analog: IMR:0000710
xref_analog: IMR:0100318
xref_analog: IMR:0100514
xref_analog: PubMed:11163210
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000889 ! TGF beta receptor I degradation signaling

[Term]
id: IEV:0000892
name: Ubiquitination of TGF beta receptor I by smurf2 in cytosol
xref_analog: IMR:0000710
xref_analog: IMR:0100514
xref_analog: PubMed:11163210
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000889 ! TGF beta receptor I degradation signaling

[Term]
id: IEV:0000893
name: Proteasome degradation of TGF beta receptor I by 26S proteasome in plasma membrane
xref_analog: IMR:0000310
xref_analog: IMR:0000710
xref_analog: PubMed:11163210
is_a: IEV:0000206 ! Proteasome degradation in plasma membrane
relationship: part_of IEV:0000889 ! TGF beta receptor I degradation signaling

[Term]
id: IEV:0000894
name: Dissociation of Smad7:smurf2 and TGF beta receptor I_Ub in cytosol
xref_analog: IMR:0000710
xref_analog: IMR:0100318
xref_analog: IMR:0100514
xref_analog: PubMed:11163210
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000889 ! TGF beta receptor I degradation signaling

[Term]
id: IEV:0000895
name: R-Smad degradation signaling
def: "The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome." [GO:0030579]
exact_synonym: "ubiquitin-dependent SMAD protein breakdown" []
exact_synonym: "ubiquitin-dependent SMAD protein catabolic process" []
exact_synonym: "ubiquitin-dependent SMAD protein catabolism" []
exact_synonym: "ubiquitin-dependent SMAD protein degradation" []
xref_analog: GO:0030579
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
relationship: part_of IEV:0000904 ! Negative feedback regulation pathway of TGF beta superfamily signaling by (R-Smad degradation through smurf1/2)

[Term]
id: IEV:0000896
name: Binding of Smad7:smurf1/2 and R-Smad in cytosol
xref_analog: IMR:0000371
xref_analog: IMR:0100318
xref_analog: IMR:0100513
xref_analog: IMR:0100514
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000895 ! R-Smad degradation signaling

[Term]
id: IEV:0000897
name: Ubiquitination of R-Smad_Ub by smurf1/2 in cytosol
xref_analog: IMR:0000371
xref_analog: IMR:0100513
xref_analog: IMR:0100514
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000895 ! R-Smad degradation signaling

[Term]
id: IEV:0000898
name: Dissociation of Smad7:smurf1/2 and R-Smad_Ub in cytosol
xref_analog: IMR:0000371
xref_analog: IMR:0100318
xref_analog: IMR:0100513
xref_analog: IMR:0100514
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000895 ! R-Smad degradation signaling

[Term]
id: IEV:0000899
name: Proteasome degradation of R-Smad by 26S proteasome in cytosol
xref_analog: IMR:0000310
xref_analog: IMR:0000371
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000895 ! R-Smad degradation signaling

[Term]
id: IEV:0000900
name: Nuclear export of mRNA (I-Smad)
exact_synonym: "Nuclear export of mRNA (Smad6/7)" []
xref_analog: IMR:0000373
is_a: IEV:0000909 ! Nuclear export of mRNA
relationship: part_of IEV:0000886 ! Gene expression of I-Smad by R-Smad:Smad4

[Term]
id: IEV:0000901
name: Transcription of I-Smad by R-Smad:Smad4 in nucleus
exact_synonym: "Transcription of Smad6/7 by R-Smad:Smad4 in nucleus" []
xref_analog: IMR:0000371
xref_analog: IMR:0000373
xref_analog: IMR:0100315
is_a: IEV:0000155 ! Transcription by R-Smad:Smad4 in nucleus
relationship: part_of IEV:0000886 ! Gene expression of I-Smad by R-Smad:Smad4

[Term]
id: IEV:0000902
name: Translation of I-Smad in cytosol
exact_synonym: "Translation of Smad6/7 in cytosol" []
xref_analog: IMR:0000373
is_a: IEV:0003550 ! Translation in cytosol
relationship: part_of IEV:0000886 ! Gene expression of I-Smad by R-Smad:Smad4

[Term]
id: IEV:0000903
name: Negative feedback regulation pathway of TGF beta superfamily signaling by (binding of I-Smad and TGF beta receptor I)
exact_synonym: "Negative feedback regulation pathway of TGF beta superfamily signaling by (binding of Smad6/7 and TGF beta receptor I)" []
xref_analog: IMR:0000093
xref_analog: IMR:0000373
is_a: IEV:0000885 ! Negative feedback regulation pathway of TGF beta superfamily signaling

[Term]
id: IEV:0000904
name: Negative feedback regulation pathway of TGF beta superfamily signaling by (R-Smad degradation through smurf1/2)
xref_analog: IMR:0000371
xref_analog: IMR:0100513
xref_analog: IMR:0100514
is_a: IEV:0000885 ! Negative feedback regulation pathway of TGF beta superfamily signaling

[Term]
id: IEV:0000905
name: Negative feedback regulation pathway of TGF beta superfamily signaling by (TGF receptor degradation by smurf)
xref_analog: IMR:0000093
xref_analog: IMR:0000094
is_a: IEV:0000885 ! Negative feedback regulation pathway of TGF beta superfamily signaling

[Term]
id: IEV:0000906
name: Gene expression of Smad7 by R-Smad:Smad4
xref_analog: IMR:0000371
xref_analog: IMR:0100315
xref_analog: IMR:0100318
is_a: IEV:0000886 ! Gene expression of I-Smad by R-Smad:Smad4
relationship: part_of IEV:0000904 ! Negative feedback regulation pathway of TGF beta superfamily signaling by (R-Smad degradation through smurf1/2)
relationship: part_of IEV:0000905 ! Negative feedback regulation pathway of TGF beta superfamily signaling by (TGF receptor degradation by smurf)

[Term]
id: IEV:0000907
name: Transcription of Smad7 by R-Smad:Smad4 in nucleus
xref_analog: IMR:0000371
xref_analog: IMR:0100315
xref_analog: IMR:0100318
is_a: IEV:0000901 ! Transcription of I-Smad by R-Smad:Smad4 in nucleus
relationship: part_of IEV:0000906 ! Gene expression of Smad7 by R-Smad:Smad4

[Term]
id: IEV:0000908
name: Translation of Smad7 in cytosol
xref_analog: IMR:0100318
is_a: IEV:0000902 ! Translation of I-Smad in cytosol
relationship: part_of IEV:0000906 ! Gene expression of Smad7 by R-Smad:Smad4

[Term]
id: IEV:0000909
name: Nuclear export of mRNA
def: "The directed movement of mRNA from the nucleus to the cytoplasm." [GO:0006406]
exact_synonym: "mRNA export from nucleus" []
exact_synonym: "mRNA export out of nucleus" []
exact_synonym: "mRNA transport from nucleus to cytoplasm" []
exact_synonym: "mRNA-nucleus export" []
xref_analog: GO:0006406
is_a: IEV:0000019 ! Nuclear export
relationship: part_of IEV:0000182 ! Gene expression

[Term]
id: IEV:0000910
name: DR4/5 signaling pathway
exact_synonym: "TRAIL signaling" []
xref_analog: REACT:402.1
is_a: IEV:0000465 ! TNFR signaling pathway

[Term]
id: IEV:0000911
name: DR3 signaling pathway
is_a: IEV:0000465 ! TNFR signaling pathway

[Term]
id: IEV:0000912
name: Ligation
def: "EC:6 catalyzed process" [EC:6.-.-.-]
xref_analog: EC:6.-.-.-
xref_analog: GO:0016874
is_a: IEV:0002721 ! enzymatic reaction

[Term]
id: IEV:0000913
name: Transference
def: "EC:2 catalyzed process" [EC:2.-.-.-]
xref_analog: EC:2.-.-.-
xref_analog: GO:0016740
is_a: IEV:0002721 ! enzymatic reaction

[Term]
id: IEV:0000914
name: Oxidation/Reduction
def: "EC:1 catalyzed process" [EC:1.-.-.-]
xref_analog: EC:1.-.-.-
xref_analog: GO:0016491
is_a: IEV:0002721 ! enzymatic reaction

[Term]
id: IEV:0000915
name: Isomerization
def: "EC:5 catalyzed process" [EC:5.-.-.-]
xref_analog: EC:5.-.-.-
xref_analog: GO:0016853
is_a: IEV:0002721 ! enzymatic reaction

[Term]
id: IEV:0000916
name: Reduction
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0000917
name: Lyase process
def: "EC:4 catalyzed process\n\n[STKE:0456] Enzyme that catalyzes the cleavage of C-C, C-O, C-S, C-N or other bonds by other means than by hydrolysis or oxidation, with two substrates in one reaction direction, and one in the other. In the latter direction, a molecule (of carbon dioxide, water, etc) is eliminated, thus creating a new double bond or a new ring.\n\n[GO:0016829] Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [GO:0016829, STKE:0456]
xref_analog: EC:4.-.-.-
xref_analog: GO:0016829
xref_analog: STKE:0456
is_a: IEV:0002721 ! enzymatic reaction

[Term]
id: IEV:0000918
name: Palmitoylation
def: "Reversible reaction that can affect C,K,T or S residues." [MI:0216]
xref_analog: MI:0216
is_a: IEV:0002681 ! lipid addition

[Term]
id: IEV:0000919
name: Farnesylation
def: "Reversible reaction that can affect C residue." [MI:0206]
xref_analog: MI:0206
is_a: IEV:0000921 ! Isoprenylation
is_a: IEV:0002681 ! lipid addition

[Term]
id: IEV:0000920
name: Geranylgeranylation
def: "Reversible reaction that can affect C residue." [MI:0209]
xref_analog: MI:0209
is_a: IEV:0000921 ! Isoprenylation
is_a: IEV:0002681 ! lipid addition

[Term]
id: IEV:0000921
name: Isoprenylation
exact_synonym: "Polyisoprenylation" []
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0000923
name: Binding of FasL and Fas in extracellular
exact_synonym: "FASL binds FAS Receptor" []
exact_synonym: "induction of apoptosis by extracellular signals" []
xref_analog: IMR:0000022
xref_analog: IMR:0010252
xref_analog: REACT:1426.2
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000161 ! Fas signaling pathway (through caspase cascade)

[Term]
id: IEV:0000924
name: Trimerization of Fas in plasma membrane
exact_synonym: "Fas trimerization" []
exact_synonym: "Trimerization of the FASL:FAS receptor complex" []
xref_analog: IMR:0010252
xref_analog: REACT:606.2
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000161 ! Fas signaling pathway (through caspase cascade)

[Term]
id: IEV:0000925
name: Binding of Fas and FADD in cytosol
exact_synonym: "FasL:Fas binds FADD" []
xref_analog: IMR:0010252
xref_analog: IMR:0100463
xref_analog: REACT:2191.3
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000161 ! Fas signaling pathway (through caspase cascade)

[Term]
id: IEV:0000926
name: Binding of FADD and pro-caspase8/10 in cytosol
exact_synonym: "DISC complex formation" []
exact_synonym: "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-10" []
exact_synonym: "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8" []
xref_analog: IMR:0100300
xref_analog: IMR:0100301
xref_analog: IMR:0100463
xref_analog: REACT:1143.2
xref_analog: REACT:1543.2
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000910 ! DR4/5 signaling pathway

[Term]
id: IEV:0000927
name: Binding of FADD and pro-caspase8 in cytosol
exact_synonym: "DISC complex formation" []
xref_analog: IMR:0100300
xref_analog: IMR:0100463
xref_analog: REACT:1038.2
xref_analog: REACT:1543.2
is_a: IEV:0000926 ! Binding of FADD and pro-caspase8/10 in cytosol
relationship: part_of IEV:0001008 ! Caspase8 activation signaling

[Term]
id: IEV:0000928
name: Binding of FADD and pro-caspase10 in cytosol
exact_synonym: "DISC complex formation" []
exact_synonym: "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-10" []
xref_analog: IMR:0100301
xref_analog: IMR:0100463
xref_analog: REACT:1143.2
xref_analog: REACT:1418.2
is_a: IEV:0000926 ! Binding of FADD and pro-caspase8/10 in cytosol
relationship: part_of IEV:0001004 ! Caspase10 activation signaling

[Term]
id: IEV:0000929
name: Caspase8/10 activation signaling
xref_analog: GO:0006919
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0000938 ! Caspase cascade (not through mitochondria)

[Term]
id: IEV:0000930
name: Homodimerization of Caspase8 in cytosol
exact_synonym: "Caspase8 homodimer formation" []
exact_synonym: "Formation of Caspase-8 dimer" []
xref_analog: IMR:0100300
xref_analog: REACT:1159.2
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001008 ! Caspase8 activation signaling

[Term]
id: IEV:0000931
name: Hydrolysis of pro-caspase8 in cytosol
exact_synonym: "Activation of Pro-Caspase 8" []
exact_synonym: "Cleavage of pro-caspase8" []
xref_analog: GO:0006919
xref_analog: IMR:0100300
xref_analog: REACT:832.2
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0001008 ! Caspase8 activation signaling

[Term]
id: IEV:0000932
name: Binding of TNFR1, TRADD, TRAF2 and RIP in cytosol
exact_synonym: "TNF:TNF-R1 binds TRADD, TRAF2 and RIP Complex" []
xref_analog: IMR:0000060
xref_analog: IMR:0000269
xref_analog: IMR:0100423
xref_analog: IMR:0100464
xref_analog: REACT:2175.2
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000114 ! TNFR1 signaling pathway (through caspase cascade)
relationship: part_of IEV:0000455 ! TNFR1 signaling pathway (through JNK cascade)

[Term]
id: IEV:0000933
name: Dissociation of TRADD:TRAF2:RIP complex and TNF alpha:TNFR1 in cytosol
exact_synonym: "TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex" []
xref_analog: IMR:0000025
xref_analog: IMR:0000060
xref_analog: IMR:0000269
xref_analog: IMR:0100423
xref_analog: IMR:0100464
xref_analog: REACT:1856.1
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000114 ! TNFR1 signaling pathway (through caspase cascade)

[Term]
id: IEV:0000934
name: Binding of TRADD and RIP in cytosol
xref_analog: IMR:0000269
xref_analog: IMR:0100464
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000932 ! Binding of TNFR1, TRADD, TRAF2 and RIP in cytosol

[Term]
id: IEV:0000935
name: Binding of DR4/5 and APO-2L in extracellular
exact_synonym: "TRAIL Binds TRAIL-Receptor2" []
xref_analog: IMR:0001200
xref_analog: IMR:0001201
xref_analog: IMR:0001202
xref_analog: REACT:2170.2
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000910 ! DR4/5 signaling pathway

[Term]
id: IEV:0000936
name: Trimerization of DR4/5 in plasma membrane
exact_synonym: "DR4/5 trimerization" []
exact_synonym: "Trimerization of TRAIL: TRAIL receptor-2 complex" []
xref_analog: IMR:0001201
xref_analog: IMR:0001202
xref_analog: REACT:1360.2
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000910 ! DR4/5 signaling pathway

[Term]
id: IEV:0000937
name: Binding of DR4/5 and FADD in cytosol
exact_synonym: "TRAIL:TRAIL receptor-2 Trimer Binds FADD" []
xref_analog: IMR:0001201
xref_analog: IMR:0001202
xref_analog: IMR:0100463
xref_analog: REACT:1721.2
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000910 ! DR4/5 signaling pathway

[Term]
id: IEV:0000938
name: Caspase cascade (not through mitochondria)
exact_synonym: "Intrinsic Pathway for Apoptosis" []
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000128 ! Caspase Cascade
relationship: part_of IEV:0000114 ! TNFR1 signaling pathway (through caspase cascade)
relationship: part_of IEV:0000161 ! Fas signaling pathway (through caspase cascade)

[Term]
id: IEV:0000939
name: Caspase cascade (through mitochondria)
exact_synonym: "Intrinsic Pathway for Apoptosis" []
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
xref_analog: REACT:964.2
is_a: IEV:0000128 ! Caspase Cascade
relationship: part_of IEV:0000114 ! TNFR1 signaling pathway (through caspase cascade)
relationship: part_of IEV:0000161 ! Fas signaling pathway (through caspase cascade)
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0000940
name: Apoptotic factor activation signaling
def: "The conversion of proteins that induce or sustain apoptosis to an active form." [GO:0008633]
exact_synonym: "activation of pro-apoptotic gene products" []
xref_analog: GO:0008633
xref_analog: REACT:697.2
is_a: IEV:0000458 ! Protein activation/inactivation signaling

[Term]
id: IEV:0000941
name: BID activation signaling
exact_synonym: "Activation, myristoylation of BID and translocation to mitochondria" []
xref_analog: GO:0008633
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
xref_analog: REACT:701.2
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0000942
name: Hydrolysis of Bid by caspase8 in cytosol
exact_synonym: "Caspase-8 activates BID by cleavage" []
xref_analog: GO:0008633
xref_analog: IMR:0100289
xref_analog: IMR:0100300
xref_analog: REACT:1320.1
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000941 ! BID activation signaling

[Term]
id: IEV:0000943
name: Hydrolysis of Bid by granzyme B in cytosol
exact_synonym: "Granzyme-B activates BID by cleavage" []
xref_analog: IMR:0001203
xref_analog: IMR:0100289
xref_analog: REACT:1610.2
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000941 ! BID activation signaling

[Term]
id: IEV:0000944
name: Myristoylation of Bid by NMT1 in cytosol
xref_analog: IMR:0001212
xref_analog: IMR:0100289
xref_analog: PubMed:11099414
xref_analog: REACT:1158.1
is_a: IEV:0000945 ! Myristoylation in cytosol
relationship: part_of IEV:0000941 ! BID activation signaling

[Term]
id: IEV:0000945
name: Myristoylation in cytosol
is_a: IEV:0000222 ! Myristoylation

[Term]
id: IEV:0000946
name: Isoprenylation in unidentified cellular location
is_a: IEV:0000921 ! Isoprenylation

[Term]
id: IEV:0000947
name: Myristoylation in unidentified cellular location
is_a: IEV:0000222 ! Myristoylation

[Term]
id: IEV:0000948
name: Translocation of Bid from the cytosol to the mitochondria membrane
xref_analog: GO:0001844
xref_analog: IMR:0100289
xref_analog: REACT:1370.3
is_a: IEV:0000412 ! Translocation from cytosol to mitochondria membrane
relationship: part_of IEV:0000941 ! BID activation signaling

[Term]
id: IEV:0000949
name: Dissociation of Bid and Bcl-2 in mitochondria membrane
xref_analog: IMR:0100261
xref_analog: IMR:0100289
xref_analog: REACT:1062.2
is_a: IEV:0000950 ! Dissociation in mitochondria membrane
relationship: part_of IEV:0001667 ! Bcl-2/Bcl-xL inactivation signaling

[Term]
id: IEV:0000950
name: Dissociation in mitochondria membrane
is_a: IEV:0001033 ! Dissociation in mitochondria

[Term]
id: IEV:0000951
name: NOXA activation signaling
exact_synonym: "Activation of NOXA and translocation to mitochondria" []
xref_analog: GO:0008633
xref_analog: REACT:1194.2
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0000952
name: Transcription of NOXA by p53 in nucleus
exact_synonym: "Transactivation of NOXA by p53" []
xref_analog: IMR:0001210
xref_analog: IMR:0100659
xref_analog: REACT:2201.3
is_a: IEV:0001661 ! Transcription of apoptotic factor by p53 in nucleus
relationship: part_of IEV:0000951 ! NOXA activation signaling
relationship: part_of IEV:0001652 ! Gene expression of NOXA by p53

[Term]
id: IEV:0000953
name: Transcription of NOXA by E2F-1 in nucleus
exact_synonym: "Transactivation of NOXA by E2F1" []
xref_analog: IMR:0000839
xref_analog: IMR:0001210
xref_analog: REACT:1872.3
is_a: IEV:0001102 ! Transcription by E2F-1 in nucleus
relationship: part_of IEV:0000951 ! NOXA activation signaling

[Term]
id: IEV:0000954
name: Translocation of NOXA from the cytosol to the mitochondria membrane
xref_analog: GO:0001844
xref_analog: IMR:0001210
xref_analog: REACT:1585.3
is_a: IEV:0000412 ! Translocation from cytosol to mitochondria membrane
relationship: part_of IEV:0000951 ! NOXA activation signaling

[Term]
id: IEV:0000955
name: PUMA activation signaling
exact_synonym: "Activation of NOXA and translocation to mitochondria" []
xref_analog: GO:0008633
xref_analog: REACT:121.2
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0000956
name: Transcription of PUMA by E2F-1 in nucleus
exact_synonym: "Transactivation of PUMA by E2F1" []
xref_analog: IMR:0000839
xref_analog: IMR:0001211
xref_analog: REACT:284.3
is_a: IEV:0001102 ! Transcription by E2F-1 in nucleus
relationship: part_of IEV:0000955 ! PUMA activation signaling

[Term]
id: IEV:0000957
name: Transcription of PUMA by p53 in nucleus
exact_synonym: "Transactivation of PUMA by p53" []
xref_analog: IMR:0001211
xref_analog: IMR:0100659
xref_analog: REACT:1555.3
is_a: IEV:0001661 ! Transcription of apoptotic factor by p53 in nucleus
relationship: part_of IEV:0000955 ! PUMA activation signaling
relationship: part_of IEV:0001653 ! Gene expression of PUMA by p53

[Term]
id: IEV:0000958
name: Translocation of PUMA from cytosol to the mitochondria membrane
exact_synonym: "Translocation of PUMA protein to mitochondria" []
xref_analog: GO:0001844
xref_analog: IMR:0001211
xref_analog: REACT:104.3
is_a: IEV:0000412 ! Translocation from cytosol to mitochondria membrane
relationship: part_of IEV:0000955 ! PUMA activation signaling

[Term]
id: IEV:0000959
name: Bim activation signaling
exact_synonym: "Activation of BIM and translocation to mitochondria" []
xref_analog: GO:0008633
xref_analog: REACT:1650.2
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0000960
name: Phosphorylation of DLC1 by MAPK8 in cytosol
xref_analog: IMR:0000683
xref_analog: IMR:0001213
xref_analog: REACT:1888.3
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000959 ! Bim activation signaling

[Term]
id: IEV:0000961
name: Dissociation of Bim and dynein:myosin V in cytosol
xref_analog: IMR:0000191
xref_analog: IMR:0000200
xref_analog: IMR:0100291
xref_analog: PubMed:10198631
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000959 ! Bim activation signaling

[Term]
id: IEV:0000962
name: Translocation of Bim from the cytosol to the mitochondria membrane
exact_synonym: "Translocation of BIM to mitochondria" []
xref_analog: GO:0001844
xref_analog: IMR:0100291
xref_analog: REACT:750.3
is_a: IEV:0000412 ! Translocation from cytosol to mitochondria membrane
relationship: part_of IEV:0000959 ! Bim activation signaling

[Term]
id: IEV:0000963
name: Bmf activation signaling
exact_synonym: "Activation of BMF and translocation to mitochondria" []
xref_analog: GO:0008633
xref_analog: REACT:2100.2
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0000964
name: Phosphorylation of DLC2 by MAPK8 in cytosol
xref_analog: IMR:0000683
xref_analog: IMR:0001209
xref_analog: REACT:1981.3
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000963 ! Bmf activation signaling

[Term]
id: IEV:0000965
name: Dissociation of Bmf and dynein:myosin V in cytosol
xref_analog: IMR:0000191
xref_analog: IMR:0000200
xref_analog: IMR:0001208
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000963 ! Bmf activation signaling

[Term]
id: IEV:0000966
name: Translocation of Bmf from the cytosol to the mitochondria membrane
exact_synonym: "Translocation of BMF to mitochondria" []
xref_analog: GO:0001844
xref_analog: IMR:0001208
xref_analog: REACT:600.3
is_a: IEV:0000412 ! Translocation from cytosol to mitochondria membrane
relationship: part_of IEV:0000963 ! Bmf activation signaling

[Term]
id: IEV:0000967
name: Inactivation in mitochondria membrane
is_a: IEV:0000007 ! Inactivation

[Term]
id: IEV:0000968
name: Inactivation of Bcl-2 by Bad in mitochondria membrane
xref_analog: IMR:0100261
xref_analog: IMR:0100288
xref_analog: REACT:330.1
is_a: IEV:0000977 ! Inactivation of Bcl-2 family by pro-apoptotic factor in mitochondria membrane

[Term]
id: IEV:0000969
name: Inactivation of Bcl-xL by Bad in mitochondria membrane
xref_analog: IMR:0100288
xref_analog: IMR:0100293
xref_analog: REACT:21278.1
is_a: IEV:0000977 ! Inactivation of Bcl-2 family by pro-apoptotic factor in mitochondria membrane

[Term]
id: IEV:0000970
name: Inactivation of Bid by Bcl-2 in mitochondria membrane
xref_analog: IMR:0100261
xref_analog: IMR:0100289
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
xref_analog: REACT:784.2
is_a: IEV:0000967 ! Inactivation in mitochondria membrane
relationship: part_of IEV:0000177 ! Negative regulation of Caspase cascade (through mitochondria)

[Term]
id: IEV:0000971
name: Inactivation of Bcl-2 by Bim in mitochondria membrane
xref_analog: IMR:0100261
xref_analog: IMR:0100291
xref_analog: REACT:330.1
is_a: IEV:0000977 ! Inactivation of Bcl-2 family by pro-apoptotic factor in mitochondria membrane

[Term]
id: IEV:0000972
name: Inactivation of Bcl-xL by Bid in mitochondria membrane
xref_analog: IMR:0100289
xref_analog: IMR:0100293
xref_analog: REACT:21278.1
is_a: IEV:0000977 ! Inactivation of Bcl-2 family by pro-apoptotic factor in mitochondria membrane

[Term]
id: IEV:0000973
name: Inactivation of Bcl-xL by Bim in mitochondria membrane
xref_analog: IMR:0100291
xref_analog: IMR:0100293
xref_analog: REACT:21278.1
is_a: IEV:0000977 ! Inactivation of Bcl-2 family by pro-apoptotic factor in mitochondria membrane

[Term]
id: IEV:0000974
name: Inactivation of Bcl-2 by NOXA in mitochondria membrane
xref_analog: IMR:0001210
xref_analog: IMR:0100261
xref_analog: REACT:330.1
is_a: IEV:0000977 ! Inactivation of Bcl-2 family by pro-apoptotic factor in mitochondria membrane

[Term]
id: IEV:0000975
name: Inactivation of Bcl-2 by PUMA in mitochondria membrane
xref_analog: IMR:0001211
xref_analog: IMR:0100261
xref_analog: REACT:330.1
is_a: IEV:0000977 ! Inactivation of Bcl-2 family by pro-apoptotic factor in mitochondria membrane

[Term]
id: IEV:0000976
name: Inactivation of Bcl-xL by PUMA in mitochondria membrane
xref_analog: IMR:0001211
xref_analog: IMR:0100293
xref_analog: REACT:21278.1
is_a: IEV:0000977 ! Inactivation of Bcl-2 family by pro-apoptotic factor in mitochondria membrane

[Term]
id: IEV:0000977
name: Inactivation of Bcl-2 family by pro-apoptotic factor in mitochondria membrane
exact_synonym: "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members" []
xref_analog: IMR:0100706
xref_analog: REACT:21278.1
xref_analog: REACT:330.1
is_a: IEV:0000967 ! Inactivation in mitochondria membrane
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0000978
name: Activation of Bax by Bid in cytosol
exact_synonym: "tBID activates BAX protein" []
xref_analog: GO:0008633
xref_analog: IMR:0000453
xref_analog: IMR:0100289
xref_analog: PubMed:10950869
xref_analog: REACT:1506.2
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000167 ! Bax activation signaling

[Term]
id: IEV:0000979
name: Activation in mitochondria membrane
is_a: IEV:0000008 ! Activation

[Term]
id: IEV:0000980
name: Bak activation signaling
exact_synonym: "Activation and oligomerization of BAK protein" []
xref_analog: GO:0008633
xref_analog: REACT:707.3
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0000981
name: Activation of Bak by Bid in mitochondria membrane
exact_synonym: "tBID activates BAK protein" []
xref_analog: GO:0008633
xref_analog: IMR:0000452
xref_analog: IMR:0100289
xref_analog: REACT:1424.3
is_a: IEV:0000979 ! Activation in mitochondria membrane
relationship: part_of IEV:0000980 ! Bak activation signaling

[Term]
id: IEV:0000982
name: Oligomerization of Bak
exact_synonym: "Oligomerization of BAK at the mitochondrial membrane" []
xref_analog: IMR:0000452
xref_analog: REACT:507.2
relationship: part_of IEV:0000980 ! Bak activation signaling

[Term]
id: IEV:0000983
name: Permeabilization of mitochondria
is_obsolete: true

[Term]
id: IEV:0000984
name: Permeabilization of mitochondria and Translocation of cytochrome c/SMAC from mitochondria to cytosol
exact_synonym: "Release of apoptotic factors from the mitochondria" []
xref_analog: IMR:0001206
xref_analog: IMR:0001207
xref_analog: REACT:1322.1
is_a: IEV:0000985 ! Translocation from mitochondria to cytosol
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0000985
name: Translocation from mitochondria to cytosol
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000986
name: Permeabilization of mitochondria and Translocation of SMAC from mitochondria to cytosol
exact_synonym: "Release of SMAC from mitochondria" []
xref_analog: IMR:0001207
xref_analog: REACT:1101.3
is_a: IEV:0000984 ! Permeabilization of mitochondria and Translocation of cytochrome c/SMAC from mitochondria to cytosol

[Term]
id: IEV:0000987
name: Cytochrome c mediated signaling
def: "Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, mediated by cytochrome c." [GO:0008635]
exact_synonym: "Cytochrome c-mediated apoptotic response" []
exact_synonym: "Effector caspase3 / 7 activation signaling (through Cyt c)" []
xref_analog: GO:0008635
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
xref_analog: REACT:831.1
is_a: IEV:0001842 ! Signaling pathway
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0000988
name: SMAC mediated signaling
exact_synonym: "SMAC-mediated apoptotic response" []
xref_analog: REACT:666.1
is_a: IEV:0001842 ! Signaling pathway
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0000989
name: Apoptosome formation in cytosol
exact_synonym: "Formation of apoptosome" []
xref_analog: REACT:89.2
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001003 ! Caspase9 activation signaling

[Term]
id: IEV:0000990
name: Binding of Cyt c:Apaf1 and procaspase9 in cytosol
exact_synonym: "Cytochrome C:Apaf-1 binds Procaspase-9" []
xref_analog: IMR:0001204
xref_analog: IMR:0001206
xref_analog: IMR:0100299
xref_analog: REACT:39.3
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000989 ! Apoptosome formation in cytosol

[Term]
id: IEV:0000991
name: Hydrolysis of Procaspase9 to Caspase9 in cytosol
exact_synonym: "Cleavage of Procaspase-9 to Caspase-9" []
xref_analog: IMR:0100299
xref_analog: REACT:2116.3
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0001003 ! Caspase9 activation signaling

[Term]
id: IEV:0000992
name: Hydrolysis of Caspase3/6/7 by Caspase9 in cytosol
exact_synonym: "Activation of caspases through apoptosome-mediated cleavage" []
xref_analog: IMR:0100296
xref_analog: IMR:0100297
xref_analog: IMR:0100298
xref_analog: IMR:0100299
xref_analog: REACT:607.3
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0001006 ! Caspase3/6/7 activation signaling (through mitochondria)

[Term]
id: IEV:0000993
name: Hydrolysis of Procaspase7 to Caspase7 by Caspase9 in cytosol
exact_synonym: "Cleavage of Procaspase-7 by the apoptosome" []
xref_analog: IMR:0100298
xref_analog: IMR:0100299
xref_analog: REACT:2165.3
is_a: IEV:0000992 ! Hydrolysis of Caspase3/6/7 by Caspase9 in cytosol

[Term]
id: IEV:0000994
name: Hydrolysis of Procaspase3 to Caspase3 by Caspase9 in cytosol
exact_synonym: "Cleavage of Procaspase-3 by the apoptosome" []
xref_analog: IMR:0100296
xref_analog: IMR:0100299
xref_analog: REACT:1460.5
is_a: IEV:0000992 ! Hydrolysis of Caspase3/6/7 by Caspase9 in cytosol
relationship: part_of IEV:0003413 ! Caspase3 activation signaling (through mitochondria)

[Term]
id: IEV:0000995
name: Binding of SMAC and IAP in cytosol
exact_synonym: "SMAC binds to IAPs" []
xref_analog: IMR:0000454
xref_analog: IMR:0001207
xref_analog: REACT:2190.2
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000988 ! SMAC mediated signaling

[Term]
id: IEV:0000996
name: Dissociation of Caspase3 and SMAC:XIAP in cytosol
exact_synonym: "SMAC binds XIAP:Caspase-3" []
xref_analog: IMR:0001207
xref_analog: IMR:0100296
xref_analog: IMR:0100331
xref_analog: REACT:1300.3
is_a: IEV:0000997 ! Dissociation of Caspase and SMAC:IAP in cytosol

[Term]
id: IEV:0000997
name: Dissociation of Caspase and SMAC:IAP in cytosol
exact_synonym: "SMAC-mediated dissociation of IAP:caspase complexes" []
xref_analog: IMR:0000305
xref_analog: IMR:0000454
xref_analog: IMR:0001207
xref_analog: REACT:1767.2
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000988 ! SMAC mediated signaling

[Term]
id: IEV:0000998
name: Binding of SMAC and XIAP:Caspase3 in cytosol
exact_synonym: "SMAC binds XIAP:Caspase-3" []
xref_analog: IMR:0001207
xref_analog: IMR:0100296
xref_analog: IMR:0100331
xref_analog: REACT:1090.2
is_a: IEV:0000995 ! Binding of SMAC and IAP in cytosol

[Term]
id: IEV:0000999
name: Binding of SMAC and XIAP:Caspase7 in cytosol
exact_synonym: "SMAC binds XIAP:Caspase-7" []
xref_analog: IMR:0001207
xref_analog: IMR:0100298
xref_analog: IMR:0100331
xref_analog: REACT:2091.2
is_a: IEV:0000995 ! Binding of SMAC and IAP in cytosol

[Term]
id: IEV:0001000
name: Binding of SMAC and XIAP:Caspase9 in cytosol
exact_synonym: "SMAC binds XIAP:Caspase-9" []
xref_analog: IMR:0001207
xref_analog: IMR:0100299
xref_analog: IMR:0100331
xref_analog: REACT:1312.2
is_a: IEV:0000995 ! Binding of SMAC and IAP in cytosol

[Term]
id: IEV:0001001
name: Dissociation of Caspase7 and SMAC:XIAP in cytosol
exact_synonym: "Dissociation of Caspase-7 from SMAC:XIAP:Caspase-7" []
xref_analog: IMR:0001207
xref_analog: IMR:0100298
xref_analog: IMR:0100331
xref_analog: REACT:2102.3
is_a: IEV:0000997 ! Dissociation of Caspase and SMAC:IAP in cytosol

[Term]
id: IEV:0001002
name: Dissociation of Caspase9 and SMAC:XIAP in cytosol
exact_synonym: "Dissociation of Caspase-9 from SMAC:XIAP:Caspase-9" []
xref_analog: IMR:0001207
xref_analog: IMR:0100299
xref_analog: IMR:0100331
xref_analog: REACT:1035.3
is_a: IEV:0000997 ! Dissociation of Caspase and SMAC:IAP in cytosol

[Term]
id: IEV:0001003
name: Caspase9 activation signaling
xref_analog: GO:0006919
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0000987 ! Cytochrome c mediated signaling

[Term]
id: IEV:0001004
name: Caspase10 activation signaling
xref_analog: GO:0006919
xref_analog: GO:0008633
is_a: IEV:0000929 ! Caspase8/10 activation signaling

[Term]
id: IEV:0001005
name: Homodimerization of Caspase9 in cytosol
exact_synonym: "Caspase9 homodimer formation" []
xref_analog: IMR:0100299
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001003 ! Caspase9 activation signaling

[Term]
id: IEV:0001006
name: Caspase3/6/7 activation signaling (through mitochondria)
exact_synonym: "Activation of Effector Caspases" []
xref_analog: GO:0006919
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0000987 ! Cytochrome c mediated signaling

[Term]
id: IEV:0001007
name: Caspase3/6/7 homodimer formation in cytosol
xref_analog: IMR:0100296
xref_analog: IMR:0100297
xref_analog: IMR:0100298
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001006 ! Caspase3/6/7 activation signaling (through mitochondria)
relationship: part_of IEV:0001013 ! Caspase3/6/7 activation signaling (not through mitochondria)

[Term]
id: IEV:0001008
name: Caspase8 activation signaling
exact_synonym: "Activation of Pro-Caspase 8" []
xref_analog: GO:0006919
xref_analog: GO:0008633
xref_analog: REACT:1503.2
is_a: IEV:0000929 ! Caspase8/10 activation signaling
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0001009
name: Hydrolysis of pro-caspase10 in cytosol
exact_synonym: "Activation of Pro-Caspase10" []
exact_synonym: "Cleavage of pro-caspase10" []
xref_analog: GO:0006919
xref_analog: IMR:0100301
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0001004 ! Caspase10 activation signaling

[Term]
id: IEV:0001010
name: Homodimerization of Caspase10 in cytosol
exact_synonym: "Caspase10 homodimer formation" []
exact_synonym: "Formation of Caspase10 dimer" []
xref_analog: IMR:0100301
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001004 ! Caspase10 activation signaling

[Term]
id: IEV:0001011
name: AIF mediated signaling
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0001017 ! DNA fragmentation during apoptosis
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0001012
name: Nuclear import of AIF
xref_analog: UniProt:O95831
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001011 ! AIF mediated signaling

[Term]
id: IEV:0001013
name: Caspase3/6/7 activation signaling (not through mitochondria)
exact_synonym: "Activation of Effector Caspases" []
xref_analog: GO:0006919
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0000938 ! Caspase cascade (not through mitochondria)

[Term]
id: IEV:0001014
name: Hydrolysis of Procaspase3/6/7 by caspase8/10 in cytosol
xref_analog: IMR:0100296
xref_analog: IMR:0100297
xref_analog: IMR:0100298
xref_analog: IMR:0100300
xref_analog: IMR:0100301
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0001013 ! Caspase3/6/7 activation signaling (not through mitochondria)

[Term]
id: IEV:0001015
name: Hydrolysis of ICAD by Caspase3/7 in cytosol
xref_analog: IMR:0100296
xref_analog: IMR:0100298
xref_analog: UniProt:O00273
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0001603 ! CAD signaling

[Term]
id: IEV:0001016
name: Nuclear import of CAD
xref_analog: UniProt:O76075
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001603 ! CAD signaling

[Term]
id: IEV:0001017
name: DNA fragmentation during apoptosis
def: "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GO:0006309]
exact_synonym: "Apoptosis induced DNA fragmentation" []
xref_analog: GO:0006309
xref_analog: REACT:1213.3
is_a: IEV:0001104 ! DNA damage
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0001018
name: Regulation of Caspase cascade (through mitochondria)
is_a: IEV:0000539 ! Regulation of Caspase cascade
relationship: regulates IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0001019
name: Negative regulation of Caspase cascade
is_a: IEV:0000539 ! Regulation of Caspase cascade
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0000128 ! Caspase Cascade

[Term]
id: IEV:0001020
name: Positive regulation of Caspase cascade
is_a: IEV:0000539 ! Regulation of Caspase cascade
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0000128 ! Caspase Cascade

[Term]
id: IEV:0001021
name: Regulation of Caspase cascade (not through mitochondria)
is_a: IEV:0000539 ! Regulation of Caspase cascade
relationship: regulates IEV:0000938 ! Caspase cascade (not through mitochondria)

[Term]
id: IEV:0001022
name: Negative regulation of Caspase cascade (not through mitochondria)
is_a: IEV:0001019 ! Negative regulation of Caspase cascade
is_a: IEV:0001021 ! Regulation of Caspase cascade (not through mitochondria)
relationship: negatively_regulates IEV:0000938 ! Caspase cascade (not through mitochondria)

[Term]
id: IEV:0001023
name: Positive regulation of Caspase cascade (not through mitochondria)
is_a: IEV:0001020 ! Positive regulation of Caspase cascade
is_a: IEV:0001021 ! Regulation of Caspase cascade (not through mitochondria)
relationship: positively_regulates IEV:0000938 ! Caspase cascade (not through mitochondria)

[Term]
id: IEV:0001024
name: Binding of CAD and ICAD in cytosol
xref_analog: REACT:14379.1
xref_analog: UniProt:O00273
xref_analog: UniProt:O76075
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0001022 ! Negative regulation of Caspase cascade (not through mitochondria)

[Term]
id: IEV:0001025
name: Binding of Caspase3/7/9 and IAP in cytosol
xref_analog: IMR:0000454
xref_analog: IMR:0100296
xref_analog: IMR:0100298
xref_analog: IMR:0100299
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000177 ! Negative regulation of Caspase cascade (through mitochondria)

[Term]
id: IEV:0001026
name: Hydrolysis in nucleus
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0001027
name: DNA fragmentation by AIF in inner space of nucleus
xref_analog: UniProt:O95831
is_a: IEV:0001051 ! Hydrolysis in inner space of nucleus
relationship: part_of IEV:0001011 ! AIF mediated signaling

[Term]
id: IEV:0001028
name: DNA fragmentation by CAD in inner space of nucleus
xref_analog: UniProt:O76075
is_a: IEV:0001051 ! Hydrolysis in inner space of nucleus
relationship: part_of IEV:0001603 ! CAD signaling

[Term]
id: IEV:0001029
name: Hydrolysis of cytosolic protein by caspase3/6/7 in cytosol
exact_synonym: "cleavage of cytosolic proteins during apoptosis" []
xref_analog: GO:0030972
xref_analog: IMR:0100296
xref_analog: IMR:0100297
xref_analog: IMR:0100298
xref_analog: REACT:13541.1
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000938 ! Caspase cascade (not through mitochondria)
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0001030
name: Apoptotic factor inactivation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling

[Term]
id: IEV:0001031
name: Cytosolic cation ion concentration decline
is_a: IEV:0000771 ! Change in material concentration

[Term]
id: IEV:0001032
name: Dissociation outside the ER membrane
is_a: IEV:0000023 ! Dissociation in cytosol
is_a: IEV:0001043 ! Dissociation in ER membrane

[Term]
id: IEV:0001033
name: Dissociation in mitochondria
is_a: IEV:0000006 ! Dissociation

[Term]
id: IEV:0001034
name: Dissociation in ER
is_a: IEV:0000006 ! Dissociation

[Term]
id: IEV:0001035
name: Binding in ER
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0001036
name: Binding in mitochondria
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0001037
name: Binding outside the ER membrane
is_a: IEV:0000013 ! Binding in cytosol
is_a: IEV:0000273 ! Binding in ER membrane

[Term]
id: IEV:0001038
name: Dissociation outside the mitochondria membrane
is_a: IEV:0000023 ! Dissociation in cytosol
is_a: IEV:0000950 ! Dissociation in mitochondria membrane

[Term]
id: IEV:0001039
name: Binding in inner space of mitochondria
is_a: IEV:0001036 ! Binding in mitochondria

[Term]
id: IEV:0001040
name: Binding in inner space of ER
is_a: IEV:0001035 ! Binding in ER

[Term]
id: IEV:0001041
name: Binding in inner space of nucleus
is_a: IEV:0000015 ! Binding in nucleus

[Term]
id: IEV:0001042
name: Dissociation in nucleus
is_a: IEV:0000006 ! Dissociation

[Term]
id: IEV:0001043
name: Dissociation in ER membrane
is_a: IEV:0001034 ! Dissociation in ER

[Term]
id: IEV:0001044
name: Dissociation in inner space of ER
is_a: IEV:0001034 ! Dissociation in ER

[Term]
id: IEV:0001045
name: Dissociation in inner space of mitochondria
is_a: IEV:0001033 ! Dissociation in mitochondria

[Term]
id: IEV:0001046
name: Dissociation in inner space of nucleus
is_a: IEV:0001042 ! Dissociation in nucleus

[Term]
id: IEV:0001047
name: Dissociation in nuclear membrane
is_a: IEV:0001042 ! Dissociation in nucleus

[Term]
id: IEV:0001048
name: Dissociation outside the nuclear membrane
is_a: IEV:0000023 ! Dissociation in cytosol
is_a: IEV:0001047 ! Dissociation in nuclear membrane

[Term]
id: IEV:0001049
name: Dephosphorylation in nucleus
is_a: IEV:0001729 ! Dephosphorylation in cytosol and/or nucleus

[Term]
id: IEV:0001050
name: Dephosphorylation in inner space of nucleus
is_a: IEV:0001049 ! Dephosphorylation in nucleus

[Term]
id: IEV:0001051
name: Hydrolysis in inner space of nucleus
is_a: IEV:0001026 ! Hydrolysis in nucleus

[Term]
id: IEV:0001052
name: Isomerization in cytosol
is_a: IEV:0000915 ! Isomerization

[Term]
id: IEV:0001053
name: Isomerization in unidentified cellular location
is_a: IEV:0000915 ! Isomerization

[Term]
id: IEV:0001054
name: SUMOylation in unidentified cellular location
is_a: IEV:0000118 ! SUMOylation

[Term]
id: IEV:0001055
name: SUMOylation in cytosol
is_a: IEV:0001828 ! SUMOylation in cytosol and/or nucleus

[Term]
id: IEV:0001056
name: Proteasome degradation of cyclin D in cytosol
xref_analog: IMR:0100614
xref_analog: REACT:2142.4
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0001084 ! Cyclin D degradation signaling

[Term]
id: IEV:0001057
name: Lyase process in unidentified cellular location
is_a: IEV:0000917 ! Lyase process

[Term]
id: IEV:0001058
name: Oxidation/Reduction in unidentified cellular location
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0001059
name: Oxidation/Reduction in cytosol
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0001060
name: Farnesylation in unidentified cellular location
is_a: IEV:0000919 ! Farnesylation

[Term]
id: IEV:0001061
name: Geranylgeranylation in unidentified cellular location
is_a: IEV:0000920 ! Geranylgeranylation

[Term]
id: IEV:0001062
name: Geranylgeranylation in cytosol
is_a: IEV:0000920 ! Geranylgeranylation

[Term]
id: IEV:0001063
name: Palmitoylation in cytosol
is_a: IEV:0000918 ! Palmitoylation

[Term]
id: IEV:0001064
name: Palmitoylation in unidentified cellular location
is_a: IEV:0000918 ! Palmitoylation

[Term]
id: IEV:0001065
name: Interaction in cytosol
def: "OBSOLETE: remap to 'Unknown interaction' IEV:0000922." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0001066
name: Interaction in unidentified cellular location
def: "OBSOLETE: remap to 'Unknown interaction' IEV:0000922." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0001067
name: Decarboxylation
xref_analog: EC:4.1.1
is_a: IEV:0000917 ! Lyase process

[Term]
id: IEV:0001068
name: Decarboxylation in the cytosol
is_a: IEV:0001067 ! Decarboxylation

[Term]
id: IEV:0001069
name: Decarboxylation in the unidentified cellular location
is_a: IEV:0001067 ! Decarboxylation

[Term]
id: IEV:0001070
name: G1-S-phase transition
alt_id: IEV:0000367
def: "Progression from G1 phase to S phase of the mitotic cell cycle." [GO:0000082]
exact_synonym: "G1-S-phase transition process [Plant]" []
xref_analog: GO:0000082
xref_analog: KEGG:hsa04110
is_a: IEV:0000366 ! Cell cycle process
relationship: part_of IEV:0000211 ! Release of (eco) dormancy

[Term]
id: IEV:0001071
name: Binding of Cdk4/6 and cyclin D in cytosol
xref_analog: IMR:0100600
xref_analog: IMR:0100602
xref_analog: IMR:0100614
xref_analog: REACT:2081.2
is_a: IEV:0003860 ! Binding of CDK and cyclin in cytosol
relationship: part_of IEV:0001106 ! G1 phase

[Term]
id: IEV:0001072
name: Nuclear import of Cdk4/6_p:cyclin D
xref_analog: IMR:0100600
xref_analog: IMR:0100602
xref_analog: IMR:0100614
xref_analog: REACT:713.3
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001106 ! G1 phase

[Term]
id: IEV:0001074
name: Phosphorylation of RB by Cdk4/6 in inner space of nucleus
xref_analog: IMR:0000461
xref_analog: IMR:0100600
xref_analog: IMR:0100602
xref_analog: REACT:1882.4
is_a: IEV:0001082 ! Phosphorylation in inner space of nucleus
relationship: part_of IEV:0001106 ! G1 phase

[Term]
id: IEV:0001075
name: Binding of E2F and DP-1 in inner space of nucleus
xref_analog: IMR:0000845
xref_analog: IMR:0000848
is_a: IEV:0001041 ! Binding in inner space of nucleus

[Term]
id: IEV:0001076
name: Transcription by E2F in nucleus
xref_analog: IMR:0000848
is_a: IEV:0003549 ! Transcription in nucleus
relationship: part_of IEV:0001070 ! G1-S-phase transition
relationship: part_of IEV:0001095 ! S phase

[Term]
id: IEV:0001077
name: Dissociation of E2F-1 and RB_p in inner space of nucleus
xref_analog: IMR:0000461
xref_analog: IMR:0000839
is_a: IEV:0000390 ! Dissociation of E2F and RB_p in inner space of nucleus

[Term]
id: IEV:0001078
name: Binding of Cdk2 and cyclin E in cytosol
xref_analog: IMR:0100598
xref_analog: IMR:0100618
xref_analog: REACT:1683.3
is_a: IEV:0003860 ! Binding of CDK and cyclin in cytosol
relationship: part_of IEV:0001070 ! G1-S-phase transition

[Term]
id: IEV:0001079
name: Nuclear import of Cdk2_p:cyclin E
xref_analog: IMR:0100598
xref_analog: IMR:0100618
xref_analog: REACT:425.2
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001070 ! G1-S-phase transition

[Term]
id: IEV:0001080
name: Gene expression of p21 by p53
exact_synonym: "Transactivation of p21 by p53" []
xref_analog: IMR:0100383
xref_analog: IMR:0100659
is_a: IEV:0001110 ! Gene expression by p53
relationship: part_of IEV:0000165 ! p53 signaling pathway (through p21)

[Term]
id: IEV:0001081
name: Phosphorylation of RB by Cdk2 in inner space of nucleus
xref_analog: IMR:0000461
xref_analog: IMR:0100598
xref_analog: REACT:8993.1
is_a: IEV:0001082 ! Phosphorylation in inner space of nucleus
relationship: part_of IEV:0001070 ! G1-S-phase transition
relationship: part_of IEV:0001095 ! S phase

[Term]
id: IEV:0001082
name: Phosphorylation in inner space of nucleus
is_a: IEV:0000231 ! Phosphorylation in nucleus

[Term]
id: IEV:0001083
name: Regulation of S phase
def: "A cell cycle process that modulates the rate or extent of the progression through the S phase of the cell cycle." [GO:0033261]
exact_synonym: "regulation of progression through S phase" []
xref_analog: GO:0033261
is_a: IEV:0001403 ! Regulation of cell cycle process
relationship: regulates IEV:0001095 ! S phase

[Term]
id: IEV:0001084
name: Cyclin D degradation signaling
def: "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions." [GO:0008054]
xref_analog: GO:0008054
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
is_a: IEV:0001096 ! Negative regulation of S phase

[Term]
id: IEV:0001085
name: Proteasome degradation of cyclin E in cytosol
xref_analog: IMR:0100618
xref_analog: REACT:926.3
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000130 ! Cyclin E degradation signaling

[Term]
id: IEV:0001086
name: Ubiquitination of Cyclin E in cytosol
xref_analog: IMR:0100618
xref_analog: REACT:926.3
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000130 ! Cyclin E degradation signaling

[Term]
id: IEV:0001087
name: Binding of INK4 family and Cdk4/6 in cytosol
xref_analog: IMR:0000447
xref_analog: IMR:0100600
xref_analog: IMR:0100602
xref_analog: REACT:7947.1
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001106 ! G1 phase

[Term]
id: IEV:0001088
name: Binding of p16 and Cdk4/6 in cytosol
def: "Interacts strongly with CDK4 and CDK6. Inhibits their ability to interact with cyclins D. Could act as a negative regulator of the proliferation of normal cells." [UniProt:P42771]
xref_analog: IMR:0100600
xref_analog: IMR:0100602
xref_analog: IMR:0701007
is_a: IEV:0001087 ! Binding of INK4 family and Cdk4/6 in cytosol
relationship: part_of IEV:0001149 ! TGF beta super family signaling (through p16)

[Term]
id: IEV:0001089
name: Binding of p15 and Cdk4/6 in cytosol
def: "Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest." [UniProt:P42772]
xref_analog: IMR:0100600
xref_analog: IMR:0100602
xref_analog: IMR:0701008
is_a: IEV:0001087 ! Binding of INK4 family and Cdk4/6 in cytosol
relationship: part_of IEV:0001139 ! TGF beta super family signaling (through p15)

[Term]
id: IEV:0001090
name: Binding of p27 and Cdk2 in inner space of nucleus
def: "Involved in G1 arrest. May mediate TGF beta-induced G1 arrest. Binds to and inhibits complexes formed by cyclin E-CDK2, cyclin A-CDK2, and cyclin D1-CDK4. Interaction with nucleoporin NUP50 is required for nuclear import and for degradation of phosphorylated p27Kip1 after nuclear import." [UniProt:P46527]
xref_analog: IMR:0100384
xref_analog: IMR:0100598
xref_analog: REACT:334.3
is_a: IEV:0001041 ! Binding in inner space of nucleus
is_a: IEV:0001096 ! Negative regulation of S phase
relationship: part_of IEV:0001150 ! TGF beta super family signaling (through p27)
relationship: part_of IEV:0001152 ! Negative regulation of G1-S-phase transition pathway by contact pressure (through p27)

[Term]
id: IEV:0001091
name: Binding of p21 and Cdk2 in inner space of nucleus
def: " May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. May bind to and inhibit cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression." [UniProt:P38936]
xref_analog: IMR:0100383
xref_analog: IMR:0100598
xref_analog: REACT:334.3
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000165 ! p53 signaling pathway (through p21)
relationship: part_of IEV:0001107 ! p53 signaling pathway (through GADD45)
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)
relationship: part_of IEV:0001140 ! TGF beta super family signaling (through p21)
relationship: part_of IEV:0001153 ! Negative regulation of G1-S-phase transition pathway by contact pressure (through p21)

[Term]
id: IEV:0001092
name: Binding of GADD45 and PCNA in cytosol
def: " Binds to proliferating cell nuclear antigen. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase." [UniProt:P24522]
xref_analog: IMR:0000559
xref_analog: UniProt:P12004
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001107 ! p53 signaling pathway (through GADD45)

[Term]
id: IEV:0001093
name: Binding of p18 and Cdk4/6 in cytosol
def: "Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB." [UniProt:P42773]
xref_analog: IMR:0100600
xref_analog: IMR:0100602
xref_analog: IMR:0701009
is_a: IEV:0001087 ! Binding of INK4 family and Cdk4/6 in cytosol

[Term]
id: IEV:0001094
name: Binding of p19 and Cdk4/6 in cytosol
def: "Interacts strongly with CDK4 and CDK6." [UniProt:P55273]
xref_analog: IMR:0100600
xref_analog: IMR:0100602
xref_analog: IMR:0701013
is_a: IEV:0001087 ! Binding of INK4 family and Cdk4/6 in cytosol

[Term]
id: IEV:0001095
name: S phase
def: "Progression through S phase, the part of the cell cycle during which DNA synthesis takes place." [GO:0051320]
xref_analog: GO:0051320
xref_analog: KEGG:hsa04110
xref_analog: MeSH:D016196
is_a: IEV:0000366 ! Cell cycle process

[Term]
id: IEV:0001096
name: Negative regulation of S phase
is_a: IEV:0001083 ! Regulation of S phase
is_a: IEV:0001404 ! Negative regulation of cell cycle process
relationship: negatively_regulates IEV:0001095 ! S phase

[Term]
id: IEV:0001097
name: Positive regulation of S phase
is_a: IEV:0001083 ! Regulation of S phase
is_a: IEV:0001405 ! Positive regulation of cell cycle process
relationship: positively_regulates IEV:0001095 ! S phase

[Term]
id: IEV:0001098
name: Dephosphorylation Cdk2 by Cdc25A in cytosol
def: "Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity. It also dephosphorylates CDK2 in complex with cyclin E, in vitro." [UniProt:P30304]
xref_analog: IMR:0100598
xref_analog: IMR:0100632
xref_analog: REACT:592.4
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0001070 ! G1-S-phase transition
relationship: part_of IEV:0001095 ! S phase

[Term]
id: IEV:0001099
name: Binding of Cdk7 and Cyclin H in cytosol
xref_analog: IMR:0100603
xref_analog: IMR:0100625
is_a: IEV:0003860 ! Binding of CDK and cyclin in cytosol
relationship: part_of IEV:0001095 ! S phase

[Term]
id: IEV:0001100
name: Phosphorylation of Cdk2 by Cdk7 in cytosol
def: "Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II." [UniProt:P50613]
comment: Thr160
xref_analog: IMR:0100598
xref_analog: IMR:0100603
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001070 ! G1-S-phase transition
relationship: part_of IEV:0001095 ! S phase

[Term]
id: IEV:0001101
name: Binding of Cdk2 and Cyclin A in cytosol
xref_analog: IMR:0100598
xref_analog: IMR:0100607
xref_analog: REACT:8996.1
is_a: IEV:0003860 ! Binding of CDK and cyclin in cytosol
relationship: part_of IEV:0001095 ! S phase

[Term]
id: IEV:0001102
name: Transcription by E2F-1 in nucleus
xref_analog: IMR:0000839
xref_analog: REACT:22145.1
is_a: IEV:0001076 ! Transcription by E2F in nucleus

[Term]
id: IEV:0001103
name: p53 signaling pathway
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0001104
name: DNA damage
def: "Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand ( PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired ( DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS." [MeSH:D004249]
xref_analog: MeSH:D004249
is_a: IEV:0000071 ! Molecular event

[Term]
id: IEV:0001105
name: Activation of ATM by damaged DNA in cytosol
xref_analog: UniProt:Q13315
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000165 ! p53 signaling pathway (through p21)
relationship: part_of IEV:0001107 ! p53 signaling pathway (through GADD45)
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0001106
name: G1 phase
def: "Progression through G1 phase, one of two 'gap' phases in the cell cycle; G1 is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis." [GO:0051318]
xref_analog: GO:0051318
xref_analog: MeSH:D016193
is_a: IEV:0000366 ! Cell cycle process

[Term]
id: IEV:0001107
name: p53 signaling pathway (through GADD45)
is_a: IEV:0001103 ! p53 signaling pathway
relationship: part_of IEV:0000872 ! DNA repair

[Term]
id: IEV:0001108
name: Negative feedback regulation of p53 signaling pathway by Mdm2
xref_analog: IMR:0100660
is_a: IEV:0000463 ! Negative regulation of p53 signaling pathway

[Term]
id: IEV:0001109
name: Proteasome degradation of p53 in cytosol
xref_analog: IMR:0100659
xref_analog: PubMed:10721693
xref_analog: PubMed:15021897
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000868 ! p53 degradation signaling

[Term]
id: IEV:0001110
name: Gene expression by p53
xref_analog: IMR:0100659
is_a: IEV:0000233 ! Gene expression by transcriptional regulator

[Term]
id: IEV:0001111
name: Gene expression of GADD45 by p53
xref_analog: IMR:0000559
xref_analog: IMR:0100659
is_a: IEV:0001110 ! Gene expression by p53
relationship: part_of IEV:0001107 ! p53 signaling pathway (through GADD45)

[Term]
id: IEV:0001112
name: Gene expression of 14-3-3 by p53
xref_analog: IMR:0000456
xref_analog: IMR:0100659
is_a: IEV:0001110 ! Gene expression by p53

[Term]
id: IEV:0001113
name: Gene expression of Mdm2 by p53
xref_analog: IMR:0100659
xref_analog: IMR:0100660
xref_analog: PubMed:12860999
is_a: IEV:0001110 ! Gene expression by p53
relationship: part_of IEV:0001108 ! Negative feedback regulation of p53 signaling pathway by Mdm2

[Term]
id: IEV:0001114
name: p53 signaling pathway (through apoptotic factor)
is_a: IEV:0001103 ! p53 signaling pathway
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0001115
name: Gene expression of BAX by p53
xref_analog: IMR:0000453
xref_analog: IMR:0100659
is_a: IEV:0001604 ! Gene expression of apoptotic factor by p53

[Term]
id: IEV:0001116
name: Nuclear export of mRNA (GADD45)
xref_analog: IMR:0000559
is_a: IEV:0000909 ! Nuclear export of mRNA
relationship: part_of IEV:0001111 ! Gene expression of GADD45 by p53

[Term]
id: IEV:0001117
name: Transcription of GADD45 by p53 in nucleus
xref_analog: IMR:0000559
xref_analog: IMR:0100659
is_a: IEV:0001144 ! Transcription by p53 in nucleus
relationship: part_of IEV:0001111 ! Gene expression of GADD45 by p53

[Term]
id: IEV:0001118
name: Translation of GADD45 in cytosol
xref_analog: IMR:0000559
is_a: IEV:0003550 ! Translation in cytosol
relationship: part_of IEV:0001111 ! Gene expression of GADD45 by p53

[Term]
id: IEV:0001119
name: Nuclear export of mRNA (Mdm2)
xref_analog: IMR:0100660
xref_analog: PubMed:12860999
is_a: IEV:0000909 ! Nuclear export of mRNA
relationship: part_of IEV:0001113 ! Gene expression of Mdm2 by p53

[Term]
id: IEV:0001120
name: Transcription of Mdm2 by p53 in nucleus
xref_analog: IMR:0100659
xref_analog: IMR:0100660
xref_analog: PubMed:12860999
is_a: IEV:0001144 ! Transcription by p53 in nucleus
relationship: part_of IEV:0001113 ! Gene expression of Mdm2 by p53

[Term]
id: IEV:0001121
name: Translation of Mdm2 in cytosol
xref_analog: IMR:0100660
xref_analog: PubMed:12860999
is_a: IEV:0003550 ! Translation in cytosol
relationship: part_of IEV:0001113 ! Gene expression of Mdm2 by p53

[Term]
id: IEV:0001122
name: Regulation of p53 degradation signaling
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000868 ! p53 degradation signaling

[Term]
id: IEV:0001123
name: Negative regulation of p53 degradation signaling
is_a: IEV:0001122 ! Regulation of p53 degradation signaling
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0000868 ! p53 degradation signaling

[Term]
id: IEV:0001124
name: Positive regulation of p53 degradation signaling
is_a: IEV:0001122 ! Regulation of p53 degradation signaling
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0000868 ! p53 degradation signaling

[Term]
id: IEV:0001125
name: Nuclear export of mRNA (p21)
xref_analog: IMR:0100383
is_a: IEV:0003864 ! Nuclear export of mRNA (Cip/Kip family)
relationship: part_of IEV:0001080 ! Gene expression of p21 by p53
relationship: part_of IEV:0001158 ! Gene expression of p21 by Smad complex

[Term]
id: IEV:0001126
name: Transcription of p21 by p53 in nucleus
xref_analog: IMR:0100383
xref_analog: IMR:0100659
is_a: IEV:0001144 ! Transcription by p53 in nucleus
relationship: part_of IEV:0001080 ! Gene expression of p21 by p53

[Term]
id: IEV:0001127
name: Translation of p21 in cytosol
xref_analog: IMR:0100383
is_a: IEV:0003867 ! Translation of CKI in cytosol
relationship: part_of IEV:0001080 ! Gene expression of p21 by p53
relationship: part_of IEV:0001158 ! Gene expression of p21 by Smad complex

[Term]
id: IEV:0001128
name: Nuclear export of mRNA (BAX)
xref_analog: IMR:0000453
is_a: IEV:0000909 ! Nuclear export of mRNA
relationship: part_of IEV:0001115 ! Gene expression of BAX by p53

[Term]
id: IEV:0001129
name: Transcription of BAX by p53 in nucleus
xref_analog: IMR:0000453
xref_analog: IMR:0100659
is_a: IEV:0001661 ! Transcription of apoptotic factor by p53 in nucleus
relationship: part_of IEV:0001115 ! Gene expression of BAX by p53

[Term]
id: IEV:0001130
name: Translation of BAX in cytosol
xref_analog: IMR:0000453
is_a: IEV:0001662 ! Translation of apoptotic factor in cytosol
relationship: part_of IEV:0001115 ! Gene expression of BAX by p53

[Term]
id: IEV:0001131
name: Binding of Cdc2 and CyclinB in cytosol
exact_synonym: "Binding of Cdk1 and CyclinB in cytosol" []
xref_analog: IMR:0100597
xref_analog: IMR:0100610
xref_analog: REACT:6216.2
is_a: IEV:0003860 ! Binding of CDK and cyclin in cytosol
relationship: part_of IEV:0000368 ! G2-M-phase transition

[Term]
id: IEV:0001132
name: Binding of Cdc2 and CyclinA in cytosol
exact_synonym: "Binding of Cdk1 and CyclinA in cytosol" []
xref_analog: IMR:0100597
xref_analog: IMR:0100607
xref_analog: REACT:6308.2
is_a: IEV:0003860 ! Binding of CDK and cyclin in cytosol
relationship: part_of IEV:0000368 ! G2-M-phase transition

[Term]
id: IEV:0001133
name: Phosphorylation of Cdc2 by Cdk7 in cytosol
comment: UniProt:P50613, Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
exact_synonym: "Phosphorylation of Cdk1 by Cdk7 in cytosol" []
xref_analog: IMR:0100597
xref_analog: IMR:0100603
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000368 ! G2-M-phase transition

[Term]
id: IEV:0001134
name: Dephosphorylation Cdc2 by Cdc25C in cytosol
def: " Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity.\nCATALYTIC ACTIVITY: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [XX:<new dbxref>]
xref_analog: IMR:0100597
xref_analog: IMR:0100634
xref_analog: REACT:6257.1
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0000368 ! G2-M-phase transition

[Term]
id: IEV:0001135
name: Phosphorylation of Cdc2 by Wee1 in cytosol
def: "May act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDC2 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDC2 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDC2 occurs exclusively on Tyr-15 and phosphorylation of monomeric CDC2 does not occur.\nCATALYTIC ACTIVITY: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [UniProt:P30291]
exact_synonym: "Phosphorylation of Cdk1 by Wee1 in cytosol" []
xref_analog: IMR:0100597
xref_analog: IMR:0100640
xref_analog: REACT:6178.2
xref_analog: REACT:6327.2
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0001136 ! Negative regulation of G2-M-phase transition

[Term]
id: IEV:0001136
name: Negative regulation of G2-M-phase transition
def: "Any process that decreases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [GO:0010972]
xref_analog: GO:0010972
is_a: IEV:0001137 ! Regulation of G2-M-phase transition
is_a: IEV:0001404 ! Negative regulation of cell cycle process
relationship: negatively_regulates IEV:0000368 ! G2-M-phase transition

[Term]
id: IEV:0001137
name: Regulation of G2-M-phase transition
def: "Any process that modulates the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [GO:0010389]
xref_analog: GO:0010389
is_a: IEV:0001403 ! Regulation of cell cycle process
relationship: regulates IEV:0000368 ! G2-M-phase transition

[Term]
id: IEV:0001138
name: Positive regulation of G2-M-phase transition
def: "Any process that increases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [GO:0010971]
xref_analog: GO:0010971
is_a: IEV:0001137 ! Regulation of G2-M-phase transition
is_a: IEV:0001405 ! Positive regulation of cell cycle process
relationship: positively_regulates IEV:0000368 ! G2-M-phase transition

[Term]
id: IEV:0001139
name: TGF beta super family signaling (through p15)
exact_synonym: "TGF beta super family signaling pathway (through p15)" []
is_a: IEV:0000090 ! TGF beta super family signaling pathway
is_a: IEV:0000391 ! Negative regulation of G1-S-phase transition

[Term]
id: IEV:0001140
name: TGF beta super family signaling (through p21)
exact_synonym: "TGF beta super family signaling pathway (through p21)" []
is_a: IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0001141
name: Activation of p27 by Contact pressure in cytosol
xref_analog: IMR:0100384
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0001152 ! Negative regulation of G1-S-phase transition pathway by contact pressure (through p27)

[Term]
id: IEV:0001142
name: Gene expression by Smad complex
xref_analog: IMR:0000370
is_a: IEV:0000233 ! Gene expression by transcriptional regulator

[Term]
id: IEV:0001143
name: Gene expression of p15 by Smad complex
xref_analog: IMR:0000370
xref_analog: IMR:0701008
is_a: IEV:0001142 ! Gene expression by Smad complex
relationship: part_of IEV:0001139 ! TGF beta super family signaling (through p15)

[Term]
id: IEV:0001144
name: Transcription by p53 in nucleus
xref_analog: IMR:0100659
is_a: IEV:0003549 ! Transcription in nucleus

[Term]
id: IEV:0001145
name: Transcription by Smad complex in nucleus
xref_analog: IMR:0000370
is_a: IEV:0003549 ! Transcription in nucleus

[Term]
id: IEV:0001146
name: Nuclear export of mRNA (p15)
xref_analog: IMR:0701008
is_a: IEV:0003863 ! Nuclear export of mRNA (INK4 family)
relationship: part_of IEV:0001143 ! Gene expression of p15 by Smad complex

[Term]
id: IEV:0001147
name: Transcription of p15 by Smad complex in nucleus
xref_analog: IMR:0000370
xref_analog: IMR:0701008
is_a: IEV:0003866 ! Transcription of CKI by Smad complex in nucleus
relationship: part_of IEV:0001143 ! Gene expression of p15 by Smad complex

[Term]
id: IEV:0001148
name: Translation of p15 in cytosol
xref_analog: IMR:0701008
is_a: IEV:0003867 ! Translation of CKI in cytosol
relationship: part_of IEV:0001143 ! Gene expression of p15 by Smad complex

[Term]
id: IEV:0001149
name: TGF beta super family signaling (through p16)
exact_synonym: "TGF beta super family signaling pathway (through p16)" []
is_a: IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0001150
name: TGF beta super family signaling (through p27)
exact_synonym: "TGF beta super family signaling pathway (through p27)" []
is_a: IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0001151
name: Activation of p21 by Contact pressure in cytosol
xref_analog: IMR:0100383
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0001153 ! Negative regulation of G1-S-phase transition pathway by contact pressure (through p21)

[Term]
id: IEV:0001152
name: Negative regulation of G1-S-phase transition pathway by contact pressure (through p27)
is_a: IEV:0000391 ! Negative regulation of G1-S-phase transition

[Term]
id: IEV:0001153
name: Negative regulation of G1-S-phase transition pathway by contact pressure (through p21)
is_a: IEV:0000391 ! Negative regulation of G1-S-phase transition

[Term]
id: IEV:0001154
name: Translation of p16 in cytosol
xref_analog: IMR:0701007
is_a: IEV:0003867 ! Translation of CKI in cytosol
relationship: part_of IEV:0001155 ! Gene expression of p16 by Smad complex

[Term]
id: IEV:0001155
name: Gene expression of p16 by Smad complex
xref_analog: IMR:0000370
xref_analog: IMR:0701007
is_a: IEV:0001142 ! Gene expression by Smad complex
relationship: part_of IEV:0001149 ! TGF beta super family signaling (through p16)

[Term]
id: IEV:0001156
name: Nuclear export of mRNA (p16)
xref_analog: IMR:0701007
is_a: IEV:0003863 ! Nuclear export of mRNA (INK4 family)
relationship: part_of IEV:0001155 ! Gene expression of p16 by Smad complex

[Term]
id: IEV:0001157
name: Transcription of p16 by Smad complex in nucleus
xref_analog: IMR:0000370
xref_analog: IMR:0701007
is_a: IEV:0003866 ! Transcription of CKI by Smad complex in nucleus
relationship: part_of IEV:0001155 ! Gene expression of p16 by Smad complex

[Term]
id: IEV:0001158
name: Gene expression of p21 by Smad complex
xref_analog: IMR:0000370
xref_analog: IMR:0100383
is_a: IEV:0001142 ! Gene expression by Smad complex
relationship: part_of IEV:0001140 ! TGF beta super family signaling (through p21)

[Term]
id: IEV:0001159
name: Transcription of p21 by Smad complex in nucleus
xref_analog: IMR:0000370
xref_analog: IMR:0100383
is_a: IEV:0003866 ! Transcription of CKI by Smad complex in nucleus
relationship: part_of IEV:0001158 ! Gene expression of p21 by Smad complex

[Term]
id: IEV:0001160
name: Translation of p27 in cytosol
xref_analog: IMR:0100384
is_a: IEV:0003867 ! Translation of CKI in cytosol
relationship: part_of IEV:0001162 ! Gene expression of p27 by Smad complex

[Term]
id: IEV:0001161
name: Transcription of p27 by Smad complex in nucleus
xref_analog: IMR:0000370
xref_analog: IMR:0100384
is_a: IEV:0003866 ! Transcription of CKI by Smad complex in nucleus
relationship: part_of IEV:0001162 ! Gene expression of p27 by Smad complex

[Term]
id: IEV:0001162
name: Gene expression of p27 by Smad complex
xref_analog: IMR:0000370
xref_analog: IMR:0100384
is_a: IEV:0001142 ! Gene expression by Smad complex
relationship: part_of IEV:0001150 ! TGF beta super family signaling (through p27)

[Term]
id: IEV:0001163
name: Nuclear export of mRNA (p27)
xref_analog: IMR:0100384
is_a: IEV:0003864 ! Nuclear export of mRNA (Cip/Kip family)
relationship: part_of IEV:0001162 ! Gene expression of p27 by Smad complex

[Term]
id: IEV:0001164
name: Hydrolysis of precursor Notch by convertase in Golgi
xref_analog: IMR:0100712
xref_analog: PubMed:14985712
is_a: IEV:0001165 ! Hydrolysis in Golgi
relationship: part_of IEV:0001254 ! Notch receptor processing

[Term]
id: IEV:0001165
name: Hydrolysis in Golgi
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0001166
name: Translocation of Notch from the Golgi to plasma membrane
xref_analog: IMR:0100712
xref_analog: PubMed:14985712
is_a: IEV:0001167 ! Translocation from Golgi to plasma membrane
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001167
name: Translocation from Golgi to plasma membrane
def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [GO:0006893]
exact_synonym: "Golgi to plasma membrane transport" []
exact_synonym: "Golgi to plasma membrane vesicle-mediated transport" []
xref_analog: GO:0006893
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0001168
name: Binding of Notch and DSL ligand in extracellular
xref_analog: IMR:0001920
xref_analog: IMR:0100712
xref_analog: PubMed:14985712
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001169
name: Hydrolysis of Notch by ADAM in plasma membrane
def: "near the transmembrane domain" [XX:<new dbxref>]
xref_analog: IMR:0001865
xref_analog: IMR:0100712
xref_analog: PubMed:14985712
is_a: IEV:0000269 ! Hydrolysis in plasma membrane
relationship: part_of IEV:0001254 ! Notch receptor processing

[Term]
id: IEV:0001170
name: Hydrolysis of Notch by Presenilin in plasma membrane
def: "within the transmembrane domain" [XX:<new dbxref>]
xref_analog: IMR:0000560
xref_analog: IMR:0100712
xref_analog: PubMed:14985712
is_a: IEV:0000269 ! Hydrolysis in plasma membrane
relationship: part_of IEV:0001254 ! Notch receptor processing

[Term]
id: IEV:0001171
name: Nuclear import of Notch (NIC) from the plasma membrane
xref_analog: IMR:0100712
xref_analog: PubMed:14985712
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001172
name: Binding of Notch (NIC) and CSL in inner space of nucleus
xref_analog: IMR:0100712
xref_analog: IMR:0100723
xref_analog: PubMed:14985712
is_a: IEV:0001174 ! Binding of Notch (NIC) and transcription factor in inner space of nucleus

[Term]
id: IEV:0001173
name: Binding of Notch (NIC) and coactivator in inner space of nucleus
xref_analog: IMR:0000424
xref_analog: IMR:0100712
xref_analog: PubMed:14985712
is_a: IEV:0001174 ! Binding of Notch (NIC) and transcription factor in inner space of nucleus

[Term]
id: IEV:0001174
name: Binding of Notch (NIC) and transcription factor in inner space of nucleus
xref_analog: GO:0007221
xref_analog: IMR:0000368
xref_analog: IMR:0100712
xref_analog: PubMed:14985712
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001175
name: Dissociation of CSL and corepressor in inner space of nucleus
xref_analog: IMR:0000427
xref_analog: IMR:0100723
xref_analog: PubMed:14985712
is_a: IEV:0001046 ! Dissociation in inner space of nucleus
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001176
name: Binding of CSL and responsive element in inner space of nucleus
xref_analog: IGS:0000028
xref_analog: IMR:0100723
xref_analog: PubMed:14985712
is_a: IEV:0002098 ! Binding of transcription factor and responsive element in inner space of nucleus
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001177
name: Transcription by CSL:Notch (NIC) in nucleus
xref_analog: IMR:0100712
xref_analog: IMR:0100723
xref_analog: PubMed:14985712
is_a: IEV:0003549 ! Transcription in nucleus
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001178
name: Regulation of Notch signaling pathway
def: "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GO:0008593]
xref_analog: GO:0008593
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001179
name: Negative regulation of Notch signaling pathway
def: "Any process that stops, prevents or reduces the rate, frequency or extent of the Notch signaling pathway." [GO:0045746]
xref_analog: GO:0045746
is_a: IEV:0001178 ! Regulation of Notch signaling pathway
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001180
name: Positive regulation of Notch signaling pathway
def: "Any process that activates or increases the rate, frequency or extent of the Notch signaling pathway." [GO:0045747]
xref_analog: GO:0045747
is_a: IEV:0001178 ! Regulation of Notch signaling pathway
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001181
name: Binding of Notch and Delta in extracellular
xref_analog: IMR:0100712
xref_analog: IMR:0100718
xref_analog: PubMed:14985712
is_a: IEV:0001168 ! Binding of Notch and DSL ligand in extracellular

[Term]
id: IEV:0001182
name: Binding of Notch1 and Jagged1 in extracellular
xref_analog: IMR:0001910
xref_analog: IMR:0100714
xref_analog: PubMed:14985712
is_a: IEV:0002558 ! Binding of Notch and Serrate/Jagged in extracellular

[Term]
id: IEV:0001183
name: Binding of Notch1 and Fringe in Golgi
xref_analog: IMR:0001852
xref_analog: IMR:0100714
xref_analog: PubMed:14985712
is_a: IEV:0001184 ! Binding in Golgi
relationship: part_of IEV:0001192 ! Negative regulation of Jagged mediated Notch signaling pathway

[Term]
id: IEV:0001184
name: Binding in Golgi
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0001185
name: Binding of Notch and Fringe
xref_analog: IMR:0001852
xref_analog: IMR:0100712
xref_analog: PubMed:14985712
is_a: IEV:0000186 ! Binding in unidentified cellular location
relationship: part_of IEV:0001190 ! Positive regulation of Delta mediated Notch signaling pathway

[Term]
id: IEV:0001186
name: Delta mediated Notch signaling pathway
xref_analog: PubMed:14985712
is_a: IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001187
name: Jagged mediated Notch signaling pathway
xref_analog: PubMed:14985712
is_a: IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001188
name: Regulation of Delta mediated Notch signaling pathway
is_a: IEV:0001178 ! Regulation of Notch signaling pathway
relationship: regulates IEV:0001186 ! Delta mediated Notch signaling pathway

[Term]
id: IEV:0001189
name: Negative regulation of Delta mediated Notch signaling pathway
is_a: IEV:0001179 ! Negative regulation of Notch signaling pathway
is_a: IEV:0001188 ! Regulation of Delta mediated Notch signaling pathway
relationship: negatively_regulates IEV:0001186 ! Delta mediated Notch signaling pathway

[Term]
id: IEV:0001190
name: Positive regulation of Delta mediated Notch signaling pathway
is_a: IEV:0001180 ! Positive regulation of Notch signaling pathway
is_a: IEV:0001188 ! Regulation of Delta mediated Notch signaling pathway
relationship: positively_regulates IEV:0001186 ! Delta mediated Notch signaling pathway

[Term]
id: IEV:0001191
name: Regulation of Jagged mediated Notch signaling pathway
is_a: IEV:0001178 ! Regulation of Notch signaling pathway
relationship: regulates IEV:0001187 ! Jagged mediated Notch signaling pathway

[Term]
id: IEV:0001192
name: Negative regulation of Jagged mediated Notch signaling pathway
is_a: IEV:0001179 ! Negative regulation of Notch signaling pathway
is_a: IEV:0001191 ! Regulation of Jagged mediated Notch signaling pathway
relationship: negatively_regulates IEV:0001187 ! Jagged mediated Notch signaling pathway

[Term]
id: IEV:0001193
name: Positive regulation of Jagged mediated Notch signaling pathway
is_a: IEV:0001180 ! Positive regulation of Notch signaling pathway
is_a: IEV:0001191 ! Regulation of Jagged mediated Notch signaling pathway
relationship: positively_regulates IEV:0001187 ! Jagged mediated Notch signaling pathway

[Term]
id: IEV:0001194
name: Binding of Mint and CSL in inner space of nucleus
xref_analog: IMR:0001961
xref_analog: IMR:0100723
xref_analog: PubMed:14985712
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001179 ! Negative regulation of Notch signaling pathway
relationship: part_of IEV:0001189 ! Negative regulation of Delta mediated Notch signaling pathway
relationship: part_of IEV:0001192 ! Negative regulation of Jagged mediated Notch signaling pathway

[Term]
id: IEV:0001195
name: Activation of Deltex [Mammalian]
def: "Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.\nOBSOLETE: remap to 'Activation of Deltex' IEV:0003541." [UniProt:Q86Y01]
xref_analog: PubMed:14985712
is_obsolete: true

[Term]
id: IEV:0001196
name: Activation of Deltex [Drosophila]
def: "Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as an ubiquitin ligase protein in the Notch pathway.\nOBSOLETE: remap to 'Activation of Deltex' IEV:0003541." [UniProt:Q23985]
xref_analog: PubMed:14985712
is_obsolete: true

[Term]
id: IEV:0001197
name: Activation of Numb [Mammalian]
def: "OBSOLETE: remap to 'Activation of Numb' IEV:0003542." [XX:<new dbxref>]
xref_analog: PubMed:14985712
is_obsolete: true

[Term]
id: IEV:0001198
name: Complex formation of BCR complex and coreceptor in plasma membrane
def: "Signal transduction by the BCR and coreceptor complexes is initiated by the recruitment and activation of tyrosine kinases. Upon antigen binding, membrane immunoglobulin and the Ig alpha-Ig beta heterodimer translocate to the glycolipid and cholesterol-rich membrane microdomains (lipid rafts) wherein fatty-acid-modified Src family kinases are constitutively present. Similarly, coengagement of the BCR and CD21 with multimeric C3d(g) bound to antigen promotes CD19-CD21-CD81 partitioning to the rafts, functioning to augment and potentiate signal transduction." [PubMed:15886112]
exact_synonym: "BCR receptor complex and coreceptor complex formation" []
xref_analog: IMR:0000153
xref_analog: PubMed:15886112
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0001199
name: Actomyosin structure organization and biogenesis
def: "The assembly and arrangement of cytoskeletal structures containing both actin and myosin. The myosin may be organized into filaments." [GO:0031032]
xref_analog: GO:0031032
is_a: IEV:0000092 ! Cytoskeleton organization

[Term]
id: IEV:0001200
name: Integrin signaling pathway (through PI3K, Vav and Rac)
xref_analog: KEGG:hsa04510
relationship: part_of IEV:0000093 ! Lamellipodium biogenesis
relationship: part_of IEV:0000094 ! Membrane ruffling
relationship: part_of IEV:0000104 ! Cell migration
relationship: part_of IEV:0000124 ! Integrin signaling pathway

[Term]
id: IEV:0001201
name: Binding of Estrogen and Estrogen receptor in inner space of nucleus
xref_analog: CHEBI:50114
xref_analog: IMR:0000088
xref_analog: PubMed:11559590
xref_analog: PubMed:15385571
xref_analog: PubMed:17336390
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001202
name: Translocation of Estrogen from extracellular to cytosol
xref_analog: CHEBI:50114
xref_analog: PubMed:15385571
is_a: IEV:0001203 ! Translocation from extracellular to cytosol
relationship: part_of IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001203
name: Translocation from extracellular to cytosol
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0001204
name: Binding of Estrogen receptor and SWI/SNF complex in inner space of nucleus
xref_analog: GO:0016514
xref_analog: IMR:0000088
xref_analog: PubMed:11559590
is_a: IEV:0001208 ! Binding of Estrogen receptor and transcription factor in inner space of nucleus

[Term]
id: IEV:0001205
name: Nuclear import of Estrogen
xref_analog: CHEBI:50114
xref_analog: PubMed:15385571
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001206
name: Complex formation of Estrogen receptor in inner space of nucleus
exact_synonym: "Estrogen receptor complex formation" []
xref_analog: IMR:0000088
xref_analog: PubMed:15385571
xref_analog: PubMed:17336390
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001207
name: Binding of Estrogen receptor and responsive element in inner space of nucleus
xref_analog: IGS:0000028
xref_analog: IMR:0000088
xref_analog: PubMed:11559590
is_a: IEV:0002098 ! Binding of transcription factor and responsive element in inner space of nucleus
relationship: part_of IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001208
name: Binding of Estrogen receptor and transcription factor in inner space of nucleus
xref_analog: IMR:0000088
xref_analog: IMR:0000368
xref_analog: PubMed:11559590
is_a: IEV:0001215 ! Transcription factor complex formation with Estrogen receptor in inner space of nucleus

[Term]
id: IEV:0001209
name: Binding of Estrogen receptor and p160 coactivator in inner space of nucleus
xref_analog: IMR:0000088
xref_analog: PubMed:11559590
is_a: IEV:0001208 ! Binding of Estrogen receptor and transcription factor in inner space of nucleus

[Term]
id: IEV:0001210
name: Binding of Estrogen receptor and cyclin D1 in inner space of nucleus
xref_analog: IMR:0000088
xref_analog: IMR:0100615
xref_analog: PubMed:11559590
is_a: IEV:0001208 ! Binding of Estrogen receptor and transcription factor in inner space of nucleus

[Term]
id: IEV:0001211
name: Binding of Estrogen receptor and MTA-1 in inner space of nucleus
xref_analog: IMR:0000088
xref_analog: PubMed:11559590
xref_analog: UniProt:Q13330
is_a: IEV:0001208 ! Binding of Estrogen receptor and transcription factor in inner space of nucleus

[Term]
id: IEV:0001212
name: Binding of Estrogen receptor and corepressor in inner space of nucleus
xref_analog: IMR:0000088
xref_analog: IMR:0000427
xref_analog: PubMed:11559590
is_a: IEV:0001208 ! Binding of Estrogen receptor and transcription factor in inner space of nucleus

[Term]
id: IEV:0001213
name: Binding of Estrogen receptor and NCOR1 in inner space of nucleus
xref_analog: IMR:0000088
xref_analog: PubMed:11559590
xref_analog: UniProt:O75376
is_a: IEV:0001212 ! Binding of Estrogen receptor and corepressor in inner space of nucleus

[Term]
id: IEV:0001214
name: Binding of Estrogen receptor and NCOR2 in inner space of nucleus
xref_analog: IMR:0000088
xref_analog: PubMed:11559590
xref_analog: UniProt:Q9Y618
is_a: IEV:0001212 ! Binding of Estrogen receptor and corepressor in inner space of nucleus

[Term]
id: IEV:0001215
name: Transcription factor complex formation with Estrogen receptor in inner space of nucleus
xref_analog: IMR:0000088
xref_analog: PubMed:11136970
xref_analog: PubMed:11559590
xref_analog: PubMed:12040178
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001216
name: Binding of Transcription factor complex and CBP in inner space of nucleus
xref_analog: IMR:0000368
xref_analog: IMR:0001404
xref_analog: PubMed:11559590
is_a: IEV:0001220 ! Binding of Transcription factor complex and HAT in inner space of nucleus

[Term]
id: IEV:0001217
name: Binding of Transcription factor complex and HDAC in inner space of nucleus
xref_analog: IMR:0000368
xref_analog: IMR:0001166
xref_analog: PubMed:11559590
is_a: IEV:0001215 ! Transcription factor complex formation with Estrogen receptor in inner space of nucleus

[Term]
id: IEV:0001218
name: Binding of Transcription factor complex and pCAF in inner space of nucleus
xref_analog: IMR:0000368
xref_analog: PubMed:11559590
xref_analog: UniProt:Q92831
is_a: IEV:0001220 ! Binding of Transcription factor complex and HAT in inner space of nucleus

[Term]
id: IEV:0001219
name: Binding of Transcription factor complex and p300 in inner space of nucleus
xref_analog: IMR:0000368
xref_analog: IMR:0001405
xref_analog: PubMed:11559590
is_a: IEV:0001220 ! Binding of Transcription factor complex and HAT in inner space of nucleus

[Term]
id: IEV:0001220
name: Binding of Transcription factor complex and HAT in inner space of nucleus
xref_analog: IMR:0000368
xref_analog: IMR:0001176
xref_analog: PubMed:11559590
is_a: IEV:0001215 ! Transcription factor complex formation with Estrogen receptor in inner space of nucleus

[Term]
id: IEV:0001221
name: Transcription by Estrogen receptor in nucleus
xref_analog: IMR:0000088
xref_analog: PubMed:11559590
is_a: IEV:0003549 ! Transcription in nucleus
relationship: part_of IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001222
name: Src activation signaling
is_a: IEV:0001589 ! Src family activation signaling

[Term]
id: IEV:0001223
name: Binding of Src and Estrogen receptor beta:MNAR
xref_analog: IMR:0100575
xref_analog: IMR:0700224
xref_analog: PubMed:12415108
is_a: IEV:0000186 ! Binding in unidentified cellular location
relationship: part_of IEV:0001313 ! Src activation signaling (through Estrogen receptor)

[Term]
id: IEV:0001224
name: Binding of Estrogen receptor and MNAR
xref_analog: IMR:0000088
xref_analog: PubMed:12415108
xref_analog: UniProt:Q8IZL8
is_a: IEV:0000186 ! Binding in unidentified cellular location
relationship: part_of IEV:0001313 ! Src activation signaling (through Estrogen receptor)

[Term]
id: IEV:0001225
name: Binding of Estrogen receptor alpha and MNAR
xref_analog: IMR:0700220
xref_analog: PubMed:12415108
xref_analog: UniProt:Q8IZL8
is_a: IEV:0001224 ! Binding of Estrogen receptor and MNAR

[Term]
id: IEV:0001226
name: Binding of Estrogen receptor beta and MNAR
xref_analog: IMR:0700224
xref_analog: PubMed:12415108
xref_analog: UniProt:Q8IZL8
is_a: IEV:0001224 ! Binding of Estrogen receptor and MNAR

[Term]
id: IEV:0001227
name: PI3K activation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling

[Term]
id: IEV:0001228
name: Binding of Estrogen receptor alpha and p85 in cytosol
xref_analog: IMR:0000266
xref_analog: IMR:0700220
xref_analog: PubMed:11029009
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001978 ! PI3K activation signaling (through Estrogen receptor)

[Term]
id: IEV:0001229
name: Binding of Estrogen and Estrogen receptor alpha in inner space of nucleus
xref_analog: CHEBI:50114
xref_analog: IMR:0700220
xref_analog: PubMed:11559590
is_a: IEV:0001201 ! Binding of Estrogen and Estrogen receptor in inner space of nucleus

[Term]
id: IEV:0001230
name: Binding of Estrogen and Estrogen receptor beta in inner space of nucleus
xref_analog: CHEBI:50114
xref_analog: IMR:0700224
xref_analog: PubMed:11559590
is_a: IEV:0001201 ! Binding of Estrogen and Estrogen receptor in inner space of nucleus
relationship: part_of IEV:0001978 ! PI3K activation signaling (through Estrogen receptor)

[Term]
id: IEV:0001231
name: Steroid receptor signaling pathway
def: "Any series of molecular signals generated as a consequence of a steroid hormone binding to its receptor." [GO:0030518]
exact_synonym: "steroid hormone receptor signaling pathway" []
xref_analog: GO:0030518
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0001232
name: Androgen receptor signaling pathway
def: "Any series of molecular signals generated as a consequence of an androgen binding to its receptor." [GO:0030521]
xref_analog: GO:0030521
is_a: IEV:0001231 ! Steroid receptor signaling pathway

[Term]
id: IEV:0001233
name: TPO signaling pathway (JAK2, STAT3)
is_a: IEV:0000044 ! JAK STAT pathway
relationship: part_of IEV:0000120 ! TPO signaling pathway

[Term]
id: IEV:0001234
name: TPO signaling pathway (through Sos, Ras and Erk cascade)
relationship: part_of IEV:0000120 ! TPO signaling pathway

[Term]
id: IEV:0001235
name: TPO signaling pathway (through PI3K, PLCgamma and PKC)
relationship: part_of IEV:0000120 ! TPO signaling pathway

[Term]
id: IEV:0001236
name: Binding of Glutamate and NMDA receptor
xref_analog: IMR:0000083
xref_analog: IMR:0100119
xref_analog: PubMed:12536131
xref_analog: PubMed:14556714
is_a: IEV:0000186 ! Binding in unidentified cellular location
relationship: part_of IEV:0000125 ! Glutamate receptor signaling pathway

[Term]
id: IEV:0001237
name: Binding of Glutamate and AMPA receptor
xref_analog: IMR:0100119
xref_analog: PubMed:14556714
is_a: IEV:0000186 ! Binding in unidentified cellular location
relationship: part_of IEV:0000125 ! Glutamate receptor signaling pathway

[Term]
id: IEV:0001238
name: Translocation of sodium ion from extracellular to cytosol (through AMPA receptor)
xref_analog: KEGG:C01330
xref_analog: PubMed:14556714
is_a: IEV:0001203 ! Translocation from extracellular to cytosol
relationship: part_of IEV:0000125 ! Glutamate receptor signaling pathway

[Term]
id: IEV:0001239
name: Changes in polarization state of the membrane
is_a: IEV:0000744 ! Neurological system process

[Term]
id: IEV:0001240
name: Depolarization state of the postsynaptic cell
xref_analog: PubMed:14556714
is_a: IEV:0001241 ! Changes in polarization state of postsynaptic cell membrane
relationship: part_of IEV:0000125 ! Glutamate receptor signaling pathway

[Term]
id: IEV:0001241
name: Changes in polarization state of postsynaptic cell membrane
is_a: IEV:0001239 ! Changes in polarization state of the membrane

[Term]
id: IEV:0001242
name: Dissociation of magnesium ion and NMDA receptor in plasma membrane
xref_analog: IMR:0000083
xref_analog: KEGG:C00305
xref_analog: PubMed:14556714
is_a: IEV:0000665 ! Dissociation in plasma membrane
relationship: part_of IEV:0001247 ! Cytosolic calcium ion concentration elevation (through Glutamate receptor)

[Term]
id: IEV:0001243
name: Translocation of calcium and sodium ion from extracellular to cytosol (through NMDA receptor)
xref_analog: IMR:0100031
xref_analog: KEGG:C01330
xref_analog: PubMed:14556714
is_a: IEV:0001203 ! Translocation from extracellular to cytosol
relationship: part_of IEV:0001247 ! Cytosolic calcium ion concentration elevation (through Glutamate receptor)

[Term]
id: IEV:0001244
name: Long-Term Potentiation
xref_analog: KEGG:hsa04720
xref_analog: PubMed:14556714
is_a: IEV:0000744 ! Neurological system process

[Term]
id: IEV:0001245
name: Binding of calcium ion and calmodulin in cytosol
xref_analog: IMR:0000457
xref_analog: IMR:0100031
xref_analog: PubMed:14556714
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001303 ! Calcineurin activation signaling
relationship: part_of IEV:0001304 ! CaMKII activation signaling

[Term]
id: IEV:0001246
name: Cytosolic calcium ion concentration elevation
def: "Any process that increases the concentration of calcium ions in the cytosol." [GO:0007204]
exact_synonym: "elevation of calcium ion concentration in cytosol" [GO:0007204]
exact_synonym: "elevation of cytosolic calcium ion concentration" [GO:0007204]
xref_analog: GO:0007204
is_a: IEV:0000771 ! Change in material concentration

[Term]
id: IEV:0001247
name: Cytosolic calcium ion concentration elevation (through Glutamate receptor)
xref_analog: PubMed:14556714
is_a: IEV:0001246 ! Cytosolic calcium ion concentration elevation
relationship: part_of IEV:0000125 ! Glutamate receptor signaling pathway

[Term]
id: IEV:0001248
name: Binding of calcium calmodulin and CaMKII in cytosol
xref_analog: IMR:0000457
xref_analog: IMR:0100031
xref_analog: IMR:0100548
xref_analog: PubMed:14556714
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001304 ! CaMKII activation signaling

[Term]
id: IEV:0001249
name: Cytosolic cation ion concentration decline (through cGMP activated cation ion channel)
is_a: IEV:0001031 ! Cytosolic cation ion concentration decline
relationship: part_of IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)

[Term]
id: IEV:0001250
name: Translocation of calcium ion from the cytosol to the extracellular
xref_analog: IMR:0100031
is_a: IEV:0001251 ! Translocation from cytosol to extracellular
relationship: part_of IEV:0001249 ! Cytosolic cation ion concentration decline (through cGMP activated cation ion channel)

[Term]
id: IEV:0001251
name: Translocation from cytosol to extracellular
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0001252
name: Binding of TCR-CD3 complex and non-receptor tyrosine kinase in cytosol
xref_analog: IMR:0000682
xref_analog: IMR:0002372
is_a: IEV:0000013 ! Binding in cytosol

[Term]
id: IEV:0001253
name: Phosphorylation of CD3 zeta by non-receptor tyrosine kinase in cytosol
xref_analog: IMR:0000682
xref_analog: IMR:0100287
xref_analog: PubMed:12040176
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0001254
name: Notch receptor processing
def: "The series of successive proteolytic cleavage events that take place after a Notch receptor binds a ligand, and which lead to the release of the Notch Intracellular Domain (NICD), which is the active form of the receptor." [GO:0007220]
xref_analog: GO:0007220
xref_analog: PubMed:14985712
is_a: IEV:0001842 ! Signaling pathway
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001255
name: Receptor recycling
def: "The process by which receptor molecules are returned to an active state and in an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal." [GO:0001881]
xref_analog: GO:0001881
relationship: part_of IEV:0003809 ! Receptor recycling mediated signaling

[Term]
id: IEV:0001257
name: PDGF receptor signaling pathway
def: "The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands." [GO:0048008]
exact_synonym: "PDGF signaling pathway" [GO:0048008]
exact_synonym: "PDGFR signaling pathway" [GO:0048008]
exact_synonym: "platelet-derived growth factor receptor signaling pathway" [GO:0048008]
xref_analog: GO:0048008
is_a: IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000104 ! Cell migration
relationship: part_of IEV:0003905 ! Lung development
relationship: part_of IEV:0003906 ! Skin development
relationship: part_of IEV:0003907 ! Male gonad development
relationship: part_of IEV:0003908 ! chemotaxis
relationship: part_of IEV:0003909 ! mitosis
relationship: part_of IEV:0003911 ! Endothelial cell differentiation
relationship: part_of IEV:0003915 ! Palate development
relationship: part_of IEV:0003917 ! Oligodendrocyte development
relationship: part_of IEV:0003919 ! Artery morphogenesis
relationship: part_of IEV:0003920 ! angiogenesis

[Term]
id: IEV:0001258
name: Ras mediated signaling
def: "A series of molecular signals within the cell that are mediated by a member of the Ras family of proteins switching to a GTP-bound active state." [GO:0007265]
exact_synonym: "Ras mediated signal transduction" [GO:0007265]
exact_synonym: "Ras protein signal transduction" [GO:0007265]
xref_analog: GO:0007265
is_a: IEV:0000676 ! Small GTPase mediated signaling

[Term]
id: IEV:0001259
name: Rac mediated signaling
def: "A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state." [GO:0016601]
exact_synonym: "Rac mediated signal transduction" [GO:0016601]
exact_synonym: "Rac protein signal transduction" [GO:0016601]
xref_analog: GO:0016601
is_a: IEV:0000676 ! Small GTPase mediated signaling

[Term]
id: IEV:0001260
name: Rho mediated signaling
def: "A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GO:0007266]
exact_synonym: "Rho mediated signal transduction" [GO:0007266]
exact_synonym: "Rho protein signal transduction" [GO:0007266]
xref_analog: GO:0007266
is_a: IEV:0000676 ! Small GTPase mediated signaling
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0001261
name: Rho-p160-myosin phosphatase signaling
xref_analog: KEGG:hsa04510
xref_analog: KEGG:hsa04810
xref_analog: KEGG:mmu04810
xref_analog: KEGG:rno04810
is_a: IEV:0001260 ! Rho mediated signaling

[Term]
id: IEV:0001262
name: Rho-PI5K signaling
xref_analog: KEGG:hsa04510
is_a: IEV:0001260 ! Rho mediated signaling

[Term]
id: IEV:0001263
name: Ral mediated signaling
def: "A series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state." [GO:0032484]
exact_synonym: "Ral protein signal transduction" []
xref_analog: GO:0032484
is_a: IEV:0000676 ! Small GTPase mediated signaling

[Term]
id: IEV:0001264
name: I-kappaB degradation signaling
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
is_a: IEV:0001269 ! Positive regulation of IKK-NF-kappaB signaling

[Term]
id: IEV:0001267
name: Regulation of IKK-NF-kappaB signaling
def: "Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade." [GO:0043122]
exact_synonym: "regulation of I-kappaB kinase/NF-kappaB cascade" []
xref_analog: GO:0043122
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0001268
name: Negative regulation of IKK-NF-kappaB signaling
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade." [GO:0043124]
exact_synonym: "downregulation of I-kappaB kinase/NF-kappaB cascade" []
exact_synonym: "negative regulation of I-kappaB kinase/NF-kappaB cascade" []
xref_analog: GO:0043124
is_a: IEV:0001267 ! Regulation of IKK-NF-kappaB signaling
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0001269
name: Positive regulation of IKK-NF-kappaB signaling
def: "Any process that activates or increases the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade." [GO:0043123]
exact_synonym: "positive regulation of I-kappaB kinase/NF-kappaB cascade" []
exact_synonym: "upregulation of I-kappaB kinase/NF-kappaB cascade" []
xref_analog: GO:0043123
is_a: IEV:0001267 ! Regulation of IKK-NF-kappaB signaling
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0001270
name: Phosphorylation of STAT by MAPK in cytosol
xref_analog: GO:0042501
xref_analog: IMR:0000224
xref_analog: IMR:0000374
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0001271
name: Complex formation of BCR in plasma membrane
exact_synonym: "BCR complex formation" []
xref_analog: IMR:0000153
xref_analog: PubMed:15886112
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0001198 ! Complex formation of BCR complex and coreceptor in plasma membrane

[Term]
id: IEV:0001272
name: Complex formation of B cell coreceptor in plasma membrane
def: "The B cell coreceptor complex, which is defined by its ability to bind and respond to C3d(g)-bound antigen, is composed of CD19, CD21 and the widely expressed CD81 and Leu13 proteins.\n" [PubMed:15886112]
exact_synonym: "B cell coreceptor complex formation" []
xref_analog: PubMed:15886112
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0001198 ! Complex formation of BCR complex and coreceptor in plasma membrane

[Term]
id: IEV:0001273
name: Regulation of B cell receptor signaling
def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GO:0050855]
exact_synonym: "Regulation of B cell receptor signaling pathway" []
xref_analog: GO:0050855
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000107 ! B cell receptor signaling pathway

[Term]
id: IEV:0001274
name: Negative regulation of B cell receptor signaling
def: "Any process that stops, prevents or reduces the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GO:0050859]
exact_synonym: "Negative regulation of B cell receptor signaling pathway" []
xref_analog: GO:0050859
is_a: IEV:0001273 ! Regulation of B cell receptor signaling
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0000107 ! B cell receptor signaling pathway

[Term]
id: IEV:0001275
name: Positive regulation of B cell receptor signaling
def: "Any process that activates or increases the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GO:0050861]
exact_synonym: "Positive regulation of B cell receptor signaling pathway" []
xref_analog: GO:0050861
is_a: IEV:0001273 ! Regulation of B cell receptor signaling
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0000107 ! B cell receptor signaling pathway

[Term]
id: IEV:0001276
name: Negative regulation of B cell receptor signaling (through CD72 and SHP-1)
xref_analog: IMR:0000275
xref_analog: PubMed:14632637
is_a: IEV:0001274 ! Negative regulation of B cell receptor signaling

[Term]
id: IEV:0001277
name: Complex formation of IgM and Ig alpha:beta in plasma membrane
exact_synonym: "IgM and Ig alpha:beta complex formation" []
xref_analog: IMR:0000154
xref_analog: IMR:0000155
xref_analog: PubMed:14632637
relationship: part_of IEV:0001271 ! Complex formation of BCR in plasma membrane

[Term]
id: IEV:0001278
name: Binding of antigen and BCR complex in extracellular
xref_analog: IMR:0000153
xref_analog: IMR:0000465
xref_analog: PubMed:14632637
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0001279
name: Phosphorylation of Ig alpha:beta by non-receptor tyrosine kinase in cytosol
def: "The immunoglobulin (Ig) and Ig cytoplasmic tails are phosphorylated on the immunoreceptor tyrosine-based activation motif (ITAM) tyrosines by Src-family tyrosine kinases (SFTKs) and/or Syk." [PubMed:14632637]
xref_analog: IMR:0000155
xref_analog: IMR:0000682
xref_analog: PubMed:14632637
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0001280
name: Phosphorylation of Ig alpha:beta by Lyn in cytosol
xref_analog: IMR:0000155
xref_analog: IMR:0000211
xref_analog: PubMed:14632637
is_a: IEV:0001282 ! Phosphorylation of Ig alpha:beta by Src family in cytosol

[Term]
id: IEV:0001281
name: Phosphorylation of Ig alpha:beta by Syk in cytosol
xref_analog: IMR:0000155
xref_analog: IMR:0000222
xref_analog: PubMed:14632637
is_a: IEV:0001279 ! Phosphorylation of Ig alpha:beta by non-receptor tyrosine kinase in cytosol

[Term]
id: IEV:0001282
name: Phosphorylation of Ig alpha:beta by Src family in cytosol
xref_analog: IMR:0000155
xref_analog: IMR:0000211
xref_analog: PubMed:14632637
is_a: IEV:0001279 ! Phosphorylation of Ig alpha:beta by non-receptor tyrosine kinase in cytosol

[Term]
id: IEV:0001283
name: Binding of Ig alpha and Syk in cytosol
def: "he B-cell linker protein (BLNK) binds to tyrosine 204 of Ig alpha." [PubMed:14632637]
xref_analog: IMR:0000222
xref_analog: IMR:0100541
xref_analog: PubMed:14632637
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0001284
name: Binding of Ig alpha and BLNK in cytosol
xref_analog: IMR:0000353
xref_analog: IMR:0100541
xref_analog: PubMed:14632637
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0001285
name: Binding of BLNK and BtK in cytosol
xref_analog: IMR:0000215
xref_analog: IMR:0000353
xref_analog: PubMed:14632637
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0002310 ! Binding of BLNK, BTK, PLC gamma2, Vav and PIP3 in cytosol

[Term]
id: IEV:0001286
name: Binding of BLNK and PLC gamma in cytosol
xref_analog: IMR:0000285
xref_analog: IMR:0000353
xref_analog: PubMed:14632637
is_a: IEV:0000013 ! Binding in cytosol

[Term]
id: IEV:0001287
name: Binding of tyrosine-phosphorylated protein and PLC in cytosol
xref_analog: IMR:0000284
xref_analog: IMR:0000949
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000471 ! PLC signaling

[Term]
id: IEV:0001288
name: Phosphorylation of PLC by non-receptor tyrosine kinase in cytosol
xref_analog: IMR:0000284
xref_analog: IMR:0000682
is_a: IEV:0003819 ! Phosphorylation of PLC by tyrosine kinase in cytosol

[Term]
id: IEV:0001289
name: Binding of DAG and PKC theta and active conformational change of PKC theta in cytosol
xref_analog: IMR:0100027
xref_analog: IMR:0100484
xref_analog: PubMed:15343367
is_a: IEV:0003426 ! Binding of DAG and nPKC and active conformational change of nPKC in cytosol
relationship: part_of IEV:0001391 ! PKC theta activation signaling

[Term]
id: IEV:0001290
name: Phosphorylation of PLC gamma by Btk in cytosol
xref_analog: IMR:0000215
xref_analog: IMR:0000285
xref_analog: PubMed:14632637
is_a: IEV:0000286 ! Phosphorylation of PLC gamma by non-receptor tyrosine kinase in cytosol

[Term]
id: IEV:0001291
name: Binding of tyrosine-phosphorylated protein and PLC gamma in cytosol
xref_analog: IMR:0000285
xref_analog: IMR:0000949
is_a: IEV:0001287 ! Binding of tyrosine-phosphorylated protein and PLC in cytosol

[Term]
id: IEV:0001292
name: Phosphorylation of Ig alpha:beta by Fyn in cytosol
xref_analog: IMR:0000155
xref_analog: IMR:0100352
xref_analog: PubMed:14632637
is_a: IEV:0001282 ! Phosphorylation of Ig alpha:beta by Src family in cytosol

[Term]
id: IEV:0001293
name: Phosphorylation of Ig alpha:beta by Blk in cytosol
xref_analog: IMR:0000155
xref_analog: PubMed:14632637
xref_analog: UniProt:P51451
is_a: IEV:0001282 ! Phosphorylation of Ig alpha:beta by Src family in cytosol

[Term]
id: IEV:0001294
name: B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
exact_synonym: "B cell receptor signaling pathway (through PLC gamma, calcineurin and NF-AT)" []
xref_analog: PubMed:14632637
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000107 ! B cell receptor signaling pathway

[Term]
id: IEV:0001295
name: B cell receptor signaling (through Ras and ERK cascade)
exact_synonym: "B cell receptor signaling pathway (through Ras and ERK cascade)" []
xref_analog: PubMed:14632637
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000107 ! B cell receptor signaling pathway

[Term]
id: IEV:0001296
name: B cell receptor signaling (through Vav and Rac)
exact_synonym: "B cell receptor signaling pathway (through Vav and Rac)" []
xref_analog: PubMed:14632637
relationship: part_of IEV:0000092 ! Cytoskeleton organization
relationship: part_of IEV:0000107 ! B cell receptor signaling pathway

[Term]
id: IEV:0001297
name: Binding of BLNK and Grb2 in cytosol
xref_analog: IMR:0000340
xref_analog: IMR:0000353
xref_analog: PubMed:14632637
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)

[Term]
id: IEV:0001298
name: B cell receptor signaling (through IKK-NF-kappaB cascade)
exact_synonym: "B cell receptor signaling pathway (through IKK-NF-kappaB cascade)" []
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000107 ! B cell receptor signaling pathway

[Term]
id: IEV:0001299
name: Binding of BLNK and Vav in cytosol
xref_analog: IMR:0000353
xref_analog: IMR:0000434
xref_analog: PubMed:14632637
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)

[Term]
id: IEV:0001300
name: Rac activation signaling
is_a: IEV:0001301 ! Small GTPase activation signaling

[Term]
id: IEV:0001301
name: Small GTPase activation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling

[Term]
id: IEV:0001302
name: Calcium ion dependent protein activation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling

[Term]
id: IEV:0001303
name: Calcineurin activation signaling
is_a: IEV:0001302 ! Calcium ion dependent protein activation signaling
relationship: part_of IEV:0000482 ! CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0001304
name: CaMKII activation signaling
is_a: IEV:0001302 ! Calcium ion dependent protein activation signaling
relationship: part_of IEV:0000125 ! Glutamate receptor signaling pathway

[Term]
id: IEV:0001305
name: Binding of calcium calmodulin and calcineurin in cytosol
xref_analog: IMR:0000278
xref_analog: IMR:0000457
xref_analog: IMR:0100031
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001303 ! Calcineurin activation signaling

[Term]
id: IEV:0001306
name: Binding of calcium ion and calcineurin in cytosol
xref_analog: IMR:0000278
xref_analog: IMR:0100031
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001303 ! Calcineurin activation signaling

[Term]
id: IEV:0001307
name: Activation of NF-kappaB by Src family in cytosol
exact_synonym: "NF-kappaB activation" []
xref_analog: IMR:0000211
xref_analog: IMR:0000382
xref_analog: PubMed:14632637
is_a: IEV:0003859 ! Activation of NF-kappaB in cytosol
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0001308
name: Transcription by NF-kappaB in nucleus
xref_analog: IMR:0000382
is_a: IEV:0003549 ! Transcription in nucleus
relationship: part_of IEV:0000783 ! Gene expression by NF-kappaB

[Term]
id: IEV:0001309
name: Dephosphorylation of NF-AT by calcineurin in cytosol
xref_analog: IMR:0000278
xref_analog: IMR:0000421
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0001310
name: Nuclear import of NF-AT
def: "The directed movement of NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors, from the cytoplasm into the nucleus. NFAT proteins are dephosphorylated in the cytoplasm by activated calcineurin, which leads to their translocation across the nuclear membrane." [GO:0051531]
exact_synonym: "NFAT protein import into nucleus" []
exact_synonym: "NFAT protein nuclear translocation" []
exact_synonym: "NFAT protein nucleus import" []
exact_synonym: "NFAT protein transport from cytoplasm to nucleus" []
xref_analog: GO:0051531
xref_analog: IMR:0000421
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0001311
name: Nuclear import of calcineurin
xref_analog: IMR:0000278
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0001312
name: Transcription by NF-AT in nucleus
xref_analog: IMR:0000421
is_a: IEV:0003549 ! Transcription in nucleus
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0001313
name: Src activation signaling (through Estrogen receptor)
xref_analog: PubMed:12415108
is_a: IEV:0001222 ! Src activation signaling

[Term]
id: IEV:0001314
name: Lymphocyte differentiation
def: "The process whereby a relatively unspecialized precursor cell acquires specialized features of B-cells, T-cells, or natural killer cells." [GO:0030098]
xref_analog: GO:0030098
is_a: IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0001315
name: Lymphocyte proliferation
def: "The rapid expansion of a lymphocyte population by cell division." [GO:0046651]
xref_analog: GO:0046651
is_a: IEV:0000076 ! Cell proliferation

[Term]
id: IEV:0001316
name: G2 phase
def: "Progression through G2 phase, one of two 'gap' phases in the cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." [GO:0051319]
xref_analog: GO:0051319
xref_analog: GO:D016195
is_a: IEV:0000366 ! Cell cycle process

[Term]
id: IEV:0001319
name: Cell communication
def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GO:0007154]
xref_analog: GO:0007154
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0001320
name: Cellular component organization
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GO:0016043]
exact_synonym: "cell component organization and biogenesis" [GO:0016043]
exact_synonym: "cell organisation" []
xref_analog: GO:0016043
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0001321
name: Cytoplasm organization
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GO:0007028]
exact_synonym: "cytoplasm organisation" []
xref_analog: GO:0007028
is_a: IEV:0001320 ! Cellular component organization

[Term]
id: IEV:0001322
name: Organelle organization
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GO:0006996]
exact_synonym: "organelle organisation" []
xref_analog: GO:0006996
is_a: IEV:0001320 ! Cellular component organization

[Term]
id: IEV:0001323
name: Actin cytoskeleton organization and biogenesis
def: "The assembly and arrangement of cytoskeletal structures comprising actin filaments and their associated proteins." [GO:0030036]
xref_analog: GO:0030036
is_a: IEV:0000092 ! Cytoskeleton organization

[Term]
id: IEV:0001324
name: Actin filament organization
def: "Control of the spatial distribution of actin filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GO:0007015]
xref_analog: GO:0007015
is_a: IEV:0001323 ! Actin cytoskeleton organization and biogenesis

[Term]
id: IEV:0001325
name: Cell morphogenesis
def: "The developmental process by which the size or shape of a cell is generated and organized. Morphogenesis pertains to the creation of form. " [GO:0000902]
exact_synonym: "cellular morphogenesis" []
xref_analog: GO:0000902
is_a: IEV:0000447 ! Anatomical structure morphogenesis
is_a: IEV:0001320 ! Cellular component organization

[Term]
id: IEV:0001326
name: Permeabilization of mitochondria and Translocation of AIF from mitochondria to cytosol
xref_analog: UniProt:O95831
is_a: IEV:0000985 ! Translocation from mitochondria to cytosol
relationship: part_of IEV:0001011 ! AIF mediated signaling

[Term]
id: IEV:0001327
name: Multicellular organismal process
def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GO:0032501]
exact_synonym: "Organismal physiological process" [GO:0050874]
xref_analog: GO:0032501
is_a: IEV:0000082 ! Organism event
is_a: IEV:0001330 ! Physiological event

[Term]
id: IEV:0001328
name: Rhythmic behavior
def: "The specific actions or reactions of an organism that recur with measured regularity." [GO:0007622]
xref_analog: GO:0007622
is_a: IEV:0000106 ! Behavior
is_a: IEV:0003807 ! Rhythmic process

[Term]
id: IEV:0001329
name: Seed development
def: "Processes aimed at the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves." [GO:0048316]
xref_analog: GO:0048316
is_a: IEV:0000398 ! Post embryonic development
is_a: IEV:0001327 ! Multicellular organismal process
is_a: IEV:0003797 ! Reproductive structure development

[Term]
id: IEV:0001330
name: Physiological event
is_a: IEV:0000003 ! Biological event

[Term]
id: IEV:0001331
name: Homeostasis
exact_synonym: "homeostatic process" []
xref_analog: GO:0042592
is_a: IEV:0001330 ! Physiological event

[Term]
id: IEV:0001332
name: Response to stimulus
def: "A change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a stimulus." [GO:0050896]
xref_analog: GO:0050896
is_a: IEV:0001330 ! Physiological event

[Term]
id: IEV:0001333
name: Response to biotic stimulus
def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a biotic stimulus." [GO:0009607]
xref_analog: GO:0009607
is_a: IEV:0001332 ! Response to stimulus

[Term]
id: IEV:0001335
name: Response to endogenous stimulus
def: "A change in state or activity of a cell or an organism as a result of the perception of an endogenous stimulus." [GO:0009719]
xref_analog: GO:0009719
is_a: IEV:0001332 ! Response to stimulus

[Term]
id: IEV:0001336
name: Response to external stimulus
def: "A change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of an external stimulus." [GO:0009605]
xref_analog: GO:0009605
is_a: IEV:0001332 ! Response to stimulus

[Term]
id: IEV:0001337
name: Response to stress
def: "A change in state or activity of an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) that occurs in response to stress, usually, but not necessarily exogenous (e.g. temperature, humidity, ionizing radiation)." [GO:0006950]
xref_analog: GO:0006950
is_a: IEV:0001332 ! Response to stimulus

[Term]
id: IEV:0001338
name: Flower formation
def: "The process that gives rise to the flower. This process pertains to the initial formation of a structure from unspecified parts." [GO:0048460]
xref_analog: GO:0048460
relationship: part_of IEV:0000577 ! Flower morphogenesis

[Term]
id: IEV:0001339
name: Wood development
alt_id: IEV:0000395
exact_synonym: "Wood formation" []
is_a: IEV:0000398 ! Post embryonic development

[Term]
id: IEV:0001340
name: Bud development
alt_id: IEV:0000399
exact_synonym: "Bud formation" []
is_a: IEV:0000398 ! Post embryonic development

[Term]
id: IEV:0001341
name: Response to wounding
def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of damage to the organism." [GO:0009611]
xref_analog: GO:0009611
is_a: IEV:0001336 ! Response to external stimulus

[Term]
id: IEV:0001342
name: Wound healing
def: "The series of events that restore integrity to a damaged tissue, following an injury." [GO:0042060]
xref_analog: GO:0042060
is_a: IEV:0001341 ! Response to wounding

[Term]
id: IEV:0001343
name: Binding of IL-2 and IL-2 receptor and conformational change of receptors in plasma membrane
def: "Combining with interleukin-2 to initiate a change in cell activity." [GO:0004911]
xref_analog: GO:0004911
xref_analog: GO:0005134
xref_analog: IMR:0000008
xref_analog: IMR:0000097
xref_analog: PubMed:10920190
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors in plasma membrane
relationship: part_of IEV:0000136 ! IL2 signaling (JAK1, JAK3, STAT5)

[Term]
id: IEV:0001344
name: Binding of IL3 and IL3 receptor and conformational change of receptors in plasma membrane
def: "Combining with interleukin-3 to initiate a change in cell activity." [GO:0004912]
xref_analog: GO:0004912
xref_analog: GO:0005135
xref_analog: IMR:0000012
xref_analog: IMR:0000109
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors in plasma membrane
relationship: part_of IEV:0000135 ! IL3 signaling pathway (JAK1, JAK2, STAT5)

[Term]
id: IEV:0001345
name: Binding of IL4 and IL4 receptor and conformational change of receptors in plasma membrane
def: "Combining with interleukin-4 to initiate a change in cell activity." [GO:0004913]
xref_analog: GO:0004913
xref_analog: GO:0005136
xref_analog: IMR:0000107
xref_analog: IMR:0000585
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors in plasma membrane
relationship: part_of IEV:0000134 ! IL4 signaling pathway (JAK1, JAK3, STAT6)
relationship: part_of IEV:0003609 ! IL13 signaling pathway (JAK1, TYK2, STAT6)

[Term]
id: IEV:0001347
name: Binding of IL-12 and IL-12 receptor and conformational change of receptors in plasma membrane
def: "Combining with interleukin-12 to initiate a change in cell activity." [GO:0016517]
xref_analog: GO:0005143
xref_analog: GO:0016517
xref_analog: IMR:0000590
xref_analog: IMR:0000602
xref_analog: PubMed:12805384
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors in plasma membrane
relationship: part_of IEV:0000138 ! IL12 signaling pathway (JAK2, TYK2, STAT4)

[Term]
id: IEV:0001348
name: Binding of IL-10 and IL-10 receptor and conformational change of receptors in plasma membrane
def: "Combining with interleukin-10 to initiate a change in cell activity." [GO:0004920]
xref_analog: GO:0004920
xref_analog: GO:0005141
xref_analog: IMR:0000589
xref_analog: IMR:0000608
xref_analog: PubMed:12626585
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors in plasma membrane
relationship: part_of IEV:0000139 ! IL10 signaling (JAK1, TYK2, STAT3)

[Term]
id: IEV:0001349
name: Phosphorylation of EGFR by PKC in cytosol
def: "PKC then phosphorylates and regulates the activity of many proteins, including EGFR; phosphorylation of a threonine residue (Thr654) in the juxtamembrane domain modulates EGF binding affinity and kinase activity of the EGFR." [PubMed:15567847]
xref_analog: IMR:0000081
xref_analog: IMR:0000245
xref_analog: PubMed:15567847
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001351 ! Negative regulation of EGF receptor signaling pathway

[Term]
id: IEV:0001350
name: Regulation of EGF signaling pathway
def: "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GO:0042058]
exact_synonym: "regulation of EGF receptor signaling pathway" [GO:0042058]
exact_synonym: "regulation of EGFR signaling pathway" [GO:0042058]
exact_synonym: "regulation of epidermal growth factor receptor signaling pathway" [GO:0042058]
xref_analog: GO:0042058
is_a: IEV:0000834 ! Regulation of RTK signaling pathway
relationship: regulates IEV:0000865 ! EGF receptor signaling pathway

[Term]
id: IEV:0001351
name: Negative regulation of EGF receptor signaling pathway
def: "Any process that stops, prevents or reduces the rate, frequency or extent of epidermal growth factor receptor signaling pathway activity." [GO:0042059]
xref_analog: GO:0042059
is_a: IEV:0000835 ! Negative regulation of RTK signaling pathway
is_a: IEV:0001350 ! Regulation of EGF signaling pathway
relationship: negatively_regulates IEV:0000865 ! EGF receptor signaling pathway

[Term]
id: IEV:0001352
name: Positive regulation of EGF signaling pathway
def: "Any process that activates or increases the rate, frequency or extent of epidermal growth factor receptor signaling pathway activity." [GO:0045742]
xref_analog: GO:0045742
is_a: IEV:0000836 ! Positive regulation of RTK signaling pathway
is_a: IEV:0001350 ! Regulation of EGF signaling pathway
relationship: positively_regulates IEV:0000865 ! EGF receptor signaling pathway

[Term]
id: IEV:0001353
name: Tyrosine biosynthesis
def: "The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GO:0006571]
exact_synonym: "tyrosine anabolism" []
exact_synonym: "tyrosine biosynthetic process" []
exact_synonym: "tyrosine formation" []
exact_synonym: "tyrosine synthesis" []
xref_analog: GO:0006571
xref_analog: KEGG:map00400
is_a: IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0001354
name: Activation of c-Raf1 by PKC beta in cytosol
def: "cPKCs (a and b1) have the potential to activate c-Raf1 in vivo while at the same time blocking further activation by growth factors and other PKC isotypes." [PubMed:9447975]
xref_analog: IMR:0001146
xref_analog: IMR:0100355
xref_analog: PubMed:9447975
is_a: IEV:0002485 ! Activation of Raf-1 by PKC in cytosol

[Term]
id: IEV:0001355
name: Activation of Raf1 by Ras-GTP along with PKC alpha in cytosol
xref_analog: IMR:0000290
xref_analog: IMR:0001145
xref_analog: IMR:0001354
xref_analog: IMR:0100355
xref_analog: PubMed:12417593
is_a: IEV:0001362 ! Activation of Raf by PKC in cytosol

[Term]
id: IEV:0001356
name: Raf activation signaling (through RKIP)
def: "Protein kinase C (PKC) regulates activation of the Raf-1 signaling cascade by growth factors, but the mechanism by which this occurs has not been elucidated. Here we report that one mechanism involves dissociation of Raf kinase inhibitory protein (RKIP) from Raf-1. Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153)." [PubMed:12551925]
xref_analog: PubMed:12551925
is_a: IEV:0001364 ! Raf activation signaling (through PKC)

[Term]
id: IEV:0001357
name: Phosphorylation of RKIP by PKC in cytosol
def: "Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153)." [PubMed:12551925]
xref_analog: IMR:0000245
xref_analog: PubMed:12551925
xref_analog: UniProt:P30086
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001356 ! Raf activation signaling (through RKIP)

[Term]
id: IEV:0001358
name: Dissociation of RKIP and Raf1 in cytosol
def: "Protein kinase C (PKC) regulates activation of the Raf-1 signaling cascade by growth factors, but the mechanism by which this occurs has not been elucidated. Here we report that one mechanism involves dissociation of Raf kinase inhibitory protein (RKIP) from Raf-1." [PubMed:12551925]
xref_analog: IMR:0100355
xref_analog: PubMed:12551925
xref_analog: UniProt:P30086
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0001356 ! Raf activation signaling (through RKIP)

[Term]
id: IEV:0001359
name: Phosphorylation of RKIP by cPKC in cytosol
def: "Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153)." [PubMed:12551925]
xref_analog: IMR:0100486
xref_analog: PubMed:12551925
xref_analog: UniProt:P30086
is_a: IEV:0001357 ! Phosphorylation of RKIP by PKC in cytosol

[Term]
id: IEV:0001360
name: Phosphorylation of RKIP by aPKC in cytosol
def: "Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153)." [PubMed:12551925]
xref_analog: IMR:0000247
xref_analog: PubMed:12551925
xref_analog: UniProt:P30086
is_a: IEV:0001357 ! Phosphorylation of RKIP by PKC in cytosol

[Term]
id: IEV:0001361
name: Activation of c-Raf1 by PKC alpha in cytosol
def: "cPKCs (a and b1) have the potential to activate c-Raf1 in vivo while at the same time blocking further activation by growth factors and other PKC isotypes." [PubMed:9447975]
xref_analog: IMR:0001145
xref_analog: IMR:0100355
xref_analog: PubMed:9447975
is_a: IEV:0002485 ! Activation of Raf-1 by PKC in cytosol

[Term]
id: IEV:0001362
name: Activation of Raf by PKC in cytosol
xref_analog: IMR:0000231
xref_analog: IMR:0000245
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0001364 ! Raf activation signaling (through PKC)

[Term]
id: IEV:0001363
name: Activation of c-Raf1 by PKC eta in cytosol
def: "At the level of Raf, the kinase that phosphorylates MEK-1, the activation cascade diverges; while conventional and novel PKCs (isotypes a and h) are potent activators of c-Raf1, atypical PKC-z cannot increase c-Raf1 activity,stimulating MEK by an independent mechanism." [PubMed:9447975]
xref_analog: IMR:0001150
xref_analog: IMR:0100355
xref_analog: PubMed:9447975
is_a: IEV:0002485 ! Activation of Raf-1 by PKC in cytosol

[Term]
id: IEV:0001364
name: Raf activation signaling (through PKC)
is_a: IEV:0002072 ! Raf activation signaling

[Term]
id: IEV:0001365
name: Binding of PLC gamma1 and PIP3 in cytosol
xref_analog: IMR:0000732
xref_analog: IMR:0001352
xref_analog: PubMed:15343367
is_a: IEV:0000469 ! Binding of PLC gamma and PIP3 in cytosol

[Term]
id: IEV:0001366
name: Hydrolysis of PIP2 by PLC gamma1 to generate DAG and IP3 in cytosol
xref_analog: IMR:0000732
xref_analog: IMR:0001350
xref_analog: IMR:0100027
xref_analog: IMR:0100028
xref_analog: PubMed:15343367
is_a: IEV:0000268 ! Hydrolysis of PIP2 by PLC gamma to generate DAG and IP3 in cytosol
relationship: part_of IEV:0000866 ! NGF receptor signaling pathway

[Term]
id: IEV:0001367
name: Binding of LAT_p and PLC gamma1 in cytosol
xref_analog: IMR:0000348
xref_analog: IMR:0000732
xref_analog: PubMed:12040176
xref_analog: PubMed:15343367
is_a: IEV:0000267 ! Binding of LAT_p and PLC gamma in cytosol

[Term]
id: IEV:0001368
name: Phosphorylation of Vav by ZAP-70 in cytosol
xref_analog: IMR:0000221
xref_analog: IMR:0000434
xref_analog: PubMed:15343367
is_a: IEV:0000264 ! Phosphorylation of Vav by non-receptor tyrosine kinase in cytosol

[Term]
id: IEV:0001369
name: Binding of SLP-76 and Vav in cytosol
xref_analog: IMR:0000350
xref_analog: IMR:0000434
xref_analog: PubMed:12040176
xref_analog: PubMed:15343367
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0001370
name: Binding of SLP-76 and Nck in cytosol
xref_analog: IMR:0000343
xref_analog: IMR:0000350
xref_analog: PubMed:12040176
xref_analog: PubMed:15343367
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0001371
name: Binding of Nck and PAK in cytosol
xref_analog: IMR:0000238
xref_analog: IMR:0000343
xref_analog: PubMed:12040176
xref_analog: PubMed:15343367
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0001372
name: Activation of IKK beta by PKC theta in cytosol
def: "T-cell lines expressing constitutively active PKC-theta, but not other constitutively active PKCs (alpha, delta, epsilon or zeta), were capable of activating an NF-kB reporter. Co-transfection experiments indicated that constitutively active PKC-theta upregulates the activity of IKKbeta, but not IKKalpha. Although a biochemical association between PKC-theta and IKKbeta could not be detected, the data suggest that PKC-theta directly or indirectly modulates IKKbeta kinase activity, thus regulating NF-kB." [PubMed:10733597]
xref_analog: IMR:0100459
xref_analog: IMR:0100484
xref_analog: PubMed:10733597
is_a: IEV:0000291 ! Activation of IKK complex by PKC theta in cytosol

[Term]
id: IEV:0001373
name: Phosphorylation of IKK complex by NIK in cytosol
def: "TNRF signaling" [XX:<new dbxref>]
xref_analog: GO:0007250
xref_analog: IMR:0000242
xref_analog: IMR:0000243
is_a: IEV:0000250 ! Phosphorylation of IKK complex by MAPKKK in cytosol

[Term]
id: IEV:0001374
name: Regulation of T cell receptor signaling pathway
def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GO:0050856]
xref_analog: GO:0050856
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000460 ! T cell receptor signaling pathway

[Term]
id: IEV:0001375
name: Negative regulation of T cell receptor signaling pathway
def: "Any process that stops, prevents or reduces the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GO:0050860]
xref_analog: GO:0050860
is_a: IEV:0001374 ! Regulation of T cell receptor signaling pathway
relationship: negatively_regulates IEV:0000460 ! T cell receptor signaling pathway

[Term]
id: IEV:0001376
name: Positive regulation of T cell receptor signaling pathway
def: "Any process that activates or increases the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GO:0050862]
xref_analog: GO:0050862
is_a: IEV:0001374 ! Regulation of T cell receptor signaling pathway
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0000460 ! T cell receptor signaling pathway

[Term]
id: IEV:0001377
name: Transcription of IL-2 by NF-kappaB in nucleus
xref_analog: IMR:0000008
xref_analog: IMR:0000382
xref_analog: PubMed:11973130
is_a: IEV:0000485 ! Transcription of IL-2 in nucleus
is_a: IEV:0001308 ! Transcription by NF-kappaB in nucleus

[Term]
id: IEV:0001378
name: Phosphorylation of IKK beta by TAK1 in cytosol
xref_analog: IMR:0000232
xref_analog: IMR:0100459
xref_analog: PubMed:15125833
is_a: IEV:0000784 ! Phosphorylation of IKK complex by TAK1 in cytosol
relationship: part_of IEV:0003444 ! IKK activation signaling (through PKC beta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001379
name: IKK activation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling

[Term]
id: IEV:0001380
name: Oligomerization of MALT1 in cytosol
xref_analog: IMR:0002662
xref_analog: PubMed:15125833
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001381
name: Oligomerization of TRAF6 in cytosol
xref_analog: IMR:0100427
xref_analog: PubMed:15125833
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001382
name: Binding of MALT1 and TRAF6 in cytosol
xref_analog: IMR:0002662
xref_analog: IMR:0100427
xref_analog: PubMed:15125833
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)
relationship: part_of IEV:0003444 ! IKK activation signaling (through PKC beta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001383
name: Binding of BCL10 and MALT1 in cytosol
xref_analog: IMR:0002658
xref_analog: IMR:0002662
xref_analog: PubMed:15125833
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001384
name: Activation of TAK1 by ubiquitinated TRAF6 in cytosol
xref_analog: IMR:0000232
xref_analog: IMR:0100427
xref_analog: PubMed:15125833
is_a: IEV:0000282 ! Activation of TAK1 in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001385
name: Recruitment of CARMA1 and BCL10 to the lipid raft of the synapse by PKC theta
xref_analog: IMR:0002655
xref_analog: IMR:0002658
xref_analog: IMR:0100484
xref_analog: PubMed:15125833
is_a: IEV:0001386 ! Recruitment to the raft
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001386
name: Recruitment to the raft
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0001387
name: IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)
is_a: IEV:0001379 ! IKK activation signaling
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0001388
name: Ubiquitination of TRAF6 by TRAF6 in cytosol
xref_analog: IMR:0100427
xref_analog: PubMed:15125833
is_a: IEV:0000202 ! Ubiquitination of TRAF6 in cytosol
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)
relationship: part_of IEV:0003444 ! IKK activation signaling (through PKC beta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001389
name: Ubiquitination of NEMO by TRAF6 in cytosol
xref_analog: IMR:0001164
xref_analog: IMR:0100427
xref_analog: PubMed:15125833
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)
relationship: part_of IEV:0003444 ! IKK activation signaling (through PKC beta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001390
name: Autophosphorylation of TAK1 in cytosol
xref_analog: IMR:0000232
xref_analog: PubMed:15125833
is_a: IEV:0000481 ! Autophosphorylation in cytosol
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001391
name: PKC theta activation signaling
xref_analog: PubMed:15343367
is_a: IEV:0000779 ! PKC activation signaling
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0001392
name: cPKC activation signaling
is_a: IEV:0000779 ! PKC activation signaling

[Term]
id: IEV:0001393
name: Binding of calcium ion and cPKC and active conformational change of cPKC in cytosol
xref_analog: IMR:0100031
xref_analog: IMR:0100486
xref_analog: PubMed:10506570
xref_analog: PubMed:7499357
is_a: IEV:0000483 ! Binding of calcium ion and PKC and active conformational change of PKC in cytosol
relationship: part_of IEV:0001392 ! cPKC activation signaling

[Term]
id: IEV:0001394
name: Binding of DAG and cPKC and active conformational change of cPKC in cytosol
xref_analog: IMR:0100027
xref_analog: IMR:0100486
xref_analog: PubMed:7499357
is_a: IEV:0000270 ! Binding of DAG and PKC and active conformational change of PKC in cytosol
relationship: part_of IEV:0001392 ! cPKC activation signaling

[Term]
id: IEV:0001395
name: Binding of DAG, calcium ion and cPKC and active conformational change of cPKC in cytosol
xref_analog: IMR:0100027
xref_analog: IMR:0100031
xref_analog: IMR:0100486
xref_analog: PubMed:7499357
is_a: IEV:0000484 ! Binding of DAG, calcium ion and PKC and active conformational change of PKC in cytosol

[Term]
id: IEV:0001396
name: Activation of MEKK3 by RIP1 in cytosol
xref_analog: IMR:0100451
xref_analog: IMR:0700610
is_a: IEV:0000257 ! Activation of MEKK3 by RIP in cytosol

[Term]
id: IEV:0001397
name: Fas signaling pathway
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
xref_analog: REACT:900.1
is_a: IEV:0000465 ! TNFR signaling pathway

[Term]
id: IEV:0001398
name: Nuclear export of mRNA (Smad7)
xref_analog: IMR:0100318
is_a: IEV:0000900 ! Nuclear export of mRNA (I-Smad)
relationship: part_of IEV:0000906 ! Gene expression of Smad7 by R-Smad:Smad4

[Term]
id: IEV:0001399
name: Binding of Smad7 and TGF beta receptor I in cytosol
xref_analog: IMR:0000710
xref_analog: IMR:0100318
is_a: IEV:0000887 ! Binding of I-Smad and TGF beta receptor I in cytosol

[Term]
id: IEV:0001400
name: Regulation of Toll-like receptor pathway
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway." [GO:0034121]
exact_synonym: "regulation of TLR signaling pathway" []
xref_analog: GO:0034121
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000462 ! Toll-like receptor signaling pathway

[Term]
id: IEV:0001401
name: Regulation of Ras mediated signaling
def: "Any process that modulates the frequency, rate or extent of Ras protein signal transduction." [GO:0046578]
exact_synonym: "regulation of Ras protein signal transduction" [GO:0046578]
xref_analog: GO:0046578
is_a: IEV:0000681 ! Regulation of small GTPase mediated signaling
relationship: regulates IEV:0001258 ! Ras mediated signaling

[Term]
id: IEV:0001402
name: Positive regulation of Ras mediated signaling
def: "Any process that activates or increases the rate, frequency or extent of Ras protein signal transduction." [GO:0046579]
exact_synonym: "positive regulation of Ras protein signal transduction" [GO:0046579]
xref_analog: GO:0046579
is_a: IEV:0000682 ! Positive regulation of small GTPase mediated signaling
is_a: IEV:0001401 ! Regulation of Ras mediated signaling
relationship: positively_regulates IEV:0001258 ! Ras mediated signaling

[Term]
id: IEV:0001403
name: Regulation of cell cycle process
def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GO:0010564]
xref_analog: GO:0010564
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000366 ! Cell cycle process

[Term]
id: IEV:0001404
name: Negative regulation of cell cycle process
def: "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GO:0010948]
xref_analog: GO:0010948
is_a: IEV:0001403 ! Regulation of cell cycle process
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0000366 ! Cell cycle process

[Term]
id: IEV:0001405
name: Positive regulation of cell cycle process
def: "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GO:0090068]
xref_analog: GO:0090068
is_a: IEV:0001403 ! Regulation of cell cycle process
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0000366 ! Cell cycle process

[Term]
id: IEV:0001406
name: Regulation of PDGF signaling pathway
is_a: IEV:0000834 ! Regulation of RTK signaling pathway
relationship: regulates IEV:0001257 ! PDGF receptor signaling pathway

[Term]
id: IEV:0001407
name: Regulation of PLC signaling
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000471 ! PLC signaling

[Term]
id: IEV:0001408
name: Negative regulation of PLC signaling
is_a: IEV:0001407 ! Regulation of PLC signaling
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0000471 ! PLC signaling

[Term]
id: IEV:0001409
name: Positive regulation of PLC signaling
is_a: IEV:0001407 ! Regulation of PLC signaling
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0000471 ! PLC signaling

[Term]
id: IEV:0001410
name: Alanine and aspartate metabolism
def: "Alanine metabolism: The chemical reactions and pathways involving alanine, 2-aminopropanoic acid. \nAspartate metabolism: The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GO:0006522, GO:0006531]
xref_analog: GO:0006522
xref_analog: GO:0006531
xref_analog: KEGG:map00250
is_a: IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001411
name: Glutamate metabolism
def: "The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GO:0006536]
exact_synonym: "glutamate metabolic process" []
exact_synonym: "glutamic acid metabolic process" []
exact_synonym: "glutamic acid metabolism" []
xref_analog: GO:0006536
xref_analog: KEGG:map00250
is_a: IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001412
name: Glycine, serine and threonine metabolism
def: "Glycine metabolism: The chemical reactions and pathways involving glycine, aminoethanoic acid. \nSerine metabolism: The chemical reactions and pathways involving L-serine, the levorotatory isomer of 2-amino-3-hydroxypropanoic acid. \nThreonine metabolism: The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GO:0006544, GO:0006563, GO:0006566]
xref_analog: GO:0006544
xref_analog: GO:0006563
xref_analog: GO:0006566
xref_analog: KEGG:map00260
is_a: IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001413
name: Glycolysis and Gluconeogenesis
def: "Glycolysis: The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) in other compounds, including pyruvate.\nGluconeogenesis: The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [GO:0006094, GO:0006096]
xref_analog: GO:0006094
xref_analog: GO:0006096
xref_analog: KEGG:map00010
is_a: IEV:0001422 ! Carbohydrate Metabolism
is_a: IEV:0003811 ! Alcohol metabolism

[Term]
id: IEV:0001414
name: Pentose phosphate pathway
def: "The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [GO:0006098]
exact_synonym: "hexose monophosphate pathway" []
exact_synonym: "pentose phosphate shunt" []
exact_synonym: "pentose-phosphate pathway" []
exact_synonym: "pentose-phosphate shunt" []
xref_analog: GO:0006098
xref_analog: KEGG:map00030
is_a: IEV:0001422 ! Carbohydrate Metabolism
is_a: IEV:0003811 ! Alcohol metabolism

[Term]
id: IEV:0001415
name: Citrate cycle (TCA cycle)
def: "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two C02 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [GO:0006099]
exact_synonym: "citric acid cycle" []
exact_synonym: "Krebs cycle" []
exact_synonym: "tricarboxylic acid cycle" []
xref_analog: GO:0006099
xref_analog: KEGG:map00020
is_a: IEV:0001555 ! Metabolism of Cofactors and Vitamins

[Term]
id: IEV:0001416
name: Pentose and glucuronate interconversions
xref_analog: KEGG:map00040
is_a: IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001417
name: Fructose and mannose metabolism
def: "Fructose metabolism: The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.\nMannose metabolism: The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GO:0006000, GO:0006013]
xref_analog: GO:0006000
xref_analog: GO:0006013
xref_analog: KEGG:map00051
is_a: IEV:0001422 ! Carbohydrate Metabolism
is_a: IEV:0003811 ! Alcohol metabolism

[Term]
id: IEV:0001418
name: Galactose metabolism
def: "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GO:0006012]
exact_synonym: "galactose metabolic process" []
xref_analog: GO:0006012
xref_analog: KEGG:map00052
is_a: IEV:0001422 ! Carbohydrate Metabolism
is_a: IEV:0003811 ! Alcohol metabolism

[Term]
id: IEV:0001419
name: Ascorbate and aldarate metabolism
def: "Ascorbate metabolism: The chemical reactions and pathways involving L-ascorbic acid, a carbohydrate-like vitamin containing six carbon atoms per molecule. Widely distributed in fruit and vegetables." [GO:0019852]
xref_analog: GO:0019852
xref_analog: KEGG:map00053
is_a: IEV:0001555 ! Metabolism of Cofactors and Vitamins
is_a: IEV:0003810 ! Carboxylic acid metabolism

[Term]
id: IEV:0001420
name: Starch and sucrose metabolism
def: "Starch metabolism: The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose.\nSucrose metabolism: The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GO:0005982, GO:0005985]
xref_analog: GO:0005982
xref_analog: GO:0005985
xref_analog: KEGG:map00500
is_a: IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001421
name: Aminosugars metabolism
def: "The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GO:0006040]
exact_synonym: "amino sugar metabolic process" []
exact_synonym: "amino sugar metabolism" []
exact_synonym: "aminosaccharide metabolic process" []
exact_synonym: "aminosaccharide metabolism" []
xref_analog: GO:0006040
xref_analog: KEGG:map00520
is_a: IEV:0001422 ! Carbohydrate Metabolism
is_a: IEV:0003811 ! Alcohol metabolism

[Term]
id: IEV:0001422
name: Carbohydrate Metabolism
def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GO:0005975]
exact_synonym: "carbohydrate metabolic process" []
xref_analog: GO:0005975
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001423
name: Nucleotide sugars metabolism
def: "The chemical reactions and pathways involving nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GO:0009225]
exact_synonym: "nucleotide-sugar metabolic process" []
xref_analog: GO:0009225
xref_analog: KEGG:map00520
is_a: IEV:0003814 ! Nucleobase, nucleoside, nucleotide and nucleic acid metabolism

[Term]
id: IEV:0001424
name: Pyruvate metabolism
def: "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GO:0006090]
exact_synonym: "pyruvate metabolic process" []
xref_analog: GO:0006090
xref_analog: KEGG:map00620
is_a: IEV:0003810 ! Carboxylic acid metabolism

[Term]
id: IEV:0001425
name: Glyoxylate and dicarboxylate metabolism
def: "Glyoxylate metabolism: The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. \nDicarboxylate metabolism: The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [GO:0043648, GO:0046487]
xref_analog: GO:0043648
xref_analog: GO:0046487
xref_analog: KEGG:map00630
is_a: IEV:0003810 ! Carboxylic acid metabolism

[Term]
id: IEV:0001426
name: Propanoate metabolism
xref_analog: KEGG:map00640
is_a: IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001427
name: Butanoate metabolism
xref_analog: KEGG:map00650
is_a: IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001428
name: C5-Branched dibasic acid metabolism
xref_analog: KEGG:map00660
is_a: IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001429
name: Inositol metabolism
def: "The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GO:0006020]
exact_synonym: "inositol metabolic process" []
exact_synonym: "vitamin Bh metabolic process" []
exact_synonym: "vitamin Bh metabolism" []
xref_analog: GO:0006020
xref_analog: KEGG:map00562
is_a: IEV:0003811 ! Alcohol metabolism

[Term]
id: IEV:0001430
name: Inositol phosphate metabolism
def: "The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GO:0043647]
exact_synonym: "inositol phosphate metabolic process" []
xref_analog: GO:0043647
xref_analog: KEGG:map00562
is_a: IEV:0001429 ! Inositol metabolism

[Term]
id: IEV:0001431
name: Oxidative phosphorylation
def: "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GO:0006119]
exact_synonym: "respiratory-chain phosphorylation" []
xref_analog: GO:0006119
xref_analog: KEGG:map00190
is_a: IEV:0001552 ! Energy Metabolism

[Term]
id: IEV:0001432
name: ATP synthesis
def: "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GO:0006754]
exact_synonym: "ATP anabolism" []
exact_synonym: "ATP biosynthesis" []
exact_synonym: "ATP biosynthetic process" []
exact_synonym: "ATP formation" []
xref_analog: GO:0006754
is_a: IEV:0001450 ! Purine metabolism
is_a: IEV:0001552 ! Energy Metabolism

[Term]
id: IEV:0001433
name: Photosynthesis
def: "The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [GO:0015979]
xref_analog: GO:0015979
xref_analog: KEGG:map00195
is_a: IEV:0001552 ! Energy Metabolism

[Term]
id: IEV:0001434
name: Carbon fixation
xref_analog: KEGG:map00710
is_a: IEV:0001552 ! Energy Metabolism

[Term]
id: IEV:0001435
name: Reductive carboxylate cycle (CO2 fixation)
xref_analog: KEGG:map00720
is_a: IEV:0001552 ! Energy Metabolism

[Term]
id: IEV:0001436
name: Methane metabolism
def: "The chemical reactions and pathways involving methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GO:0015947]
exact_synonym: "methane metabolic process" []
xref_analog: GO:0015947
xref_analog: KEGG:map00680
is_a: IEV:0001552 ! Energy Metabolism

[Term]
id: IEV:0001437
name: Nitrogen metabolism
xref_analog: KEGG:map00910
is_a: IEV:0001552 ! Energy Metabolism

[Term]
id: IEV:0001438
name: Sulfur metabolism
def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GO:0006790]
exact_synonym: "sulfur metabolic process" []
exact_synonym: "sulphur metabolic process" []
exact_synonym: "sulphur metabolism" []
xref_analog: GO:0006790
xref_analog: KEGG:map00920
is_a: IEV:0001552 ! Energy Metabolism

[Term]
id: IEV:0001439
name: Fatty acid biosynthesis
def: "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GO:0006633]
exact_synonym: "fatty acid anabolism" []
exact_synonym: "fatty acid biosynthetic process" []
exact_synonym: "fatty acid formation" []
exact_synonym: "fatty acid synthesis" []
xref_analog: GO:0006633
xref_analog: KEGG:map00061
is_a: IEV:0001441 ! Fatty acid metabolism

[Term]
id: IEV:0001440
name: Fatty acid elongation in mitochondria
def: "Fatty acid elongation: The elongation of a fatty acid chain by the sequential addition of two-carbon units." [GO:0030497]
xref_analog: GO:0030497
xref_analog: KEGG:map00062
is_a: IEV:0001439 ! Fatty acid biosynthesis

[Term]
id: IEV:0001441
name: Fatty acid metabolism
def: "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [GO:0006631]
exact_synonym: "fatty acid metabolic process" []
xref_analog: GO:0006631
xref_analog: KEGG:map00071
is_a: IEV:0001553 ! Lipid Metabolism
is_a: IEV:0003810 ! Carboxylic acid metabolism

[Term]
id: IEV:0001442
name: Ketone bodies metabolism
def: "The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism." [GO:0046950]
exact_synonym: "ketone body metabolic process" []
xref_analog: GO:0046950
xref_analog: KEGG:map00072
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001443
name: Steroid biosynthesis
def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GO:0006694]
exact_synonym: "steroid anabolism" []
exact_synonym: "steroid biosynthetic process" []
exact_synonym: "steroid formation" []
exact_synonym: "steroid synthesis" []
exact_synonym: "steroidogenesis" []
xref_analog: GO:0006694
xref_analog: KEGG:map00100
is_a: IEV:0001553 ! Lipid Metabolism

[Term]
id: IEV:0001444
name: Bile acid biosynthesis
def: "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GO:0006699]
exact_synonym: "bile acid anabolism" []
exact_synonym: "bile acid biosynthetic process" []
exact_synonym: "bile acid formation" []
exact_synonym: "bile acid synthesis" []
xref_analog: GO:0006699
xref_analog: KEGG:map00120
is_a: IEV:0001553 ! Lipid Metabolism
is_a: IEV:0003810 ! Carboxylic acid metabolism

[Term]
id: IEV:0001445
name: C21-Steroid hormone metabolism
def: "The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GO:0008207]
exact_synonym: "C21-steroid hormone metabolic process" []
xref_analog: GO:0008207
xref_analog: KEGG:map00140
is_a: IEV:0001446 ! Steroid hormone biosynthesis

[Term]
id: IEV:0001446
name: Steroid hormone biosynthesis
xref_analog: KEGG:map00140
is_a: IEV:0001553 ! Lipid Metabolism

[Term]
id: IEV:0001447
name: Glycerolipid metabolism
def: "The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis." [GO:0046486]
exact_synonym: "glycerolipid metabolic process" []
xref_analog: GO:0046486
xref_analog: KEGG:map00561
is_a: IEV:0001553 ! Lipid Metabolism

[Term]
id: IEV:0001448
name: Glycerophospholipid metabolism
def: "The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [GO:0006650]
exact_synonym: "glycerophospholipid metabolic process" []
exact_synonym: "phosphoglyceride metabolic process" []
exact_synonym: "phosphoglyceride metabolism" []
xref_analog: GO:0006650
xref_analog: KEGG:map00564
is_a: IEV:0001447 ! Glycerolipid metabolism

[Term]
id: IEV:0001449
name: Arachidonic acid metabolism
def: "The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [GO:0019369]
comment: Prostaglandin and leukotriene metabolism
xref_analog: GO:0019369
xref_analog: KEGG:map00590
is_a: IEV:0001441 ! Fatty acid metabolism

[Term]
id: IEV:0001450
name: Purine metabolism
def: "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GO:0006163]
exact_synonym: "purine nucleotide metabolism" []
xref_analog: GO:0006163
xref_analog: KEGG:map00230
is_a: IEV:0001554 ! Nucleotide Metabolism

[Term]
id: IEV:0001451
name: Pyrimidine metabolism
def: "The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GO:0006220]
exact_synonym: "pyrimidine nucleotide metabolism" []
xref_analog: GO:0006220
xref_analog: KEGG:map00240
is_a: IEV:0001554 ! Nucleotide Metabolism

[Term]
id: IEV:0001454
name: Valine, leucine and isoleucine degradation
def: "Valine degradation: The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid. \nLeucine degradation: The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid. \nIsoleucine degradation: The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GO:0006550, GO:0006552, GO:0006574]
xref_analog: GO:0006550
xref_analog: GO:0006552
xref_analog: GO:0006574
xref_analog: KEGG:map00280
is_a: IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001455
name: Valine, leucine and isoleucine biosynthesis
def: "Valine biosynthesis: The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid. \nLeucine biosynthesis: The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. \nIsoleucine biosynthesis: The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GO:0009097, GO:0009098, GO:0009099]
xref_analog: GO:0009097
xref_analog: GO:0009098
xref_analog: GO:0009099
xref_analog: KEGG:map00290
is_a: IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001456
name: Lysine biosynthesis
def: "The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid." [GO:0009085]
exact_synonym: "lysine anabolism" []
exact_synonym: "lysine biosynthetic process" []
exact_synonym: "lysine formation" []
exact_synonym: "lysine synthesis" []
xref_analog: GO:0009085
xref_analog: KEGG:map00300
is_a: IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001457
name: Lysine degradation
def: "The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid." [GO:0006554]
exact_synonym: "lysine breakdown" []
exact_synonym: "lysine catabolic process" []
exact_synonym: "lysine catabolism" []
xref_analog: GO:0006554
xref_analog: KEGG:map00310
is_a: IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001458
name: Arginine and proline metabolism
def: "Arginine metabolism: The chemical reactions and pathways involving arginine, 2-amino-5-guanidinopentanoic acid. Proline metabolism: The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GO:0006525, GO:0006560]
xref_analog: GO:0006525
xref_analog: GO:0006560
xref_analog: KEGG:map00330
is_a: IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001459
name: Histidine metabolism
def: "The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GO:0006547]
exact_synonym: "histidine metabolic process" []
xref_analog: GO:0006547
xref_analog: KEGG:map00340
is_a: IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001460
name: Tyrosine metabolism
def: "The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GO:0006570]
exact_synonym: "tyrosine metabolic process" []
xref_analog: GO:0006570
xref_analog: KEGG:map00350
is_a: IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001461
name: Phenylalanine metabolism
def: "L-phenylalanine metabolism: The chemical reactions and pathways involving L-phenylalanine, the levorotatory isomer of 2-amino-3-phenylpropanoic acid." [GO:0006558]
xref_analog: GO:0006558
xref_analog: KEGG:map00360
is_a: IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001462
name: Tryptophan metabolism
def: "The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [GO:0006568]
exact_synonym: "tryptophan metabolic process" []
xref_analog: GO:0006568
xref_analog: KEGG:map00380
is_a: IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001463
name: Phenylalanine biosynthesis
alt_id: IEV:0000410
def: "L-phenylalanine biosynthesis: The chemical reactions and pathways resulting in the formation of L-phenylalanine, the levorotatory isomer of 2-amino-3-phenylpropanoic acid." [GO:0009094]
exact_synonym: "Phenylalanine biosynthesis pathway" []
xref_analog: GO:0009094
xref_analog: KEGG:map00400
is_a: IEV:0001461 ! Phenylalanine metabolism

[Term]
id: IEV:0001464
name: Urea cycle and metabolism of amino groups
def: "A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea. \n" [GO:0000050]
xref_analog: GO:0000050
xref_analog: KEGG:map00330
is_a: IEV:0003813 ! Amide metabolism

[Term]
id: IEV:0001465
name: beta-Alanine metabolism
def: "The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GO:0019482]
exact_synonym: "beta-alanine metabolic process" []
xref_analog: GO:0019482
xref_analog: KEGG:map00410
is_a: IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001466
name: Methionine and Cysteine metabolism
alt_id: IEV:0001452
alt_id: IEV:0001453
def: "Methionine metabolism: The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.\nCysteine metabolism: The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid." [GO:0006534, GO:0006555]
xref_analog: GO:0006534
xref_analog: GO:0006555
xref_analog: KEGG:map00270
xref_analog: KEGG:map00430
is_a: IEV:0001438 ! Sulfur metabolism
is_a: IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001467
name: Aminophosphonate metabolism
def: "The chemical reactions and pathways involving aminophosphonates, amino acid derivatives that contain a phosphonic acid moiety." [GO:0033051]
exact_synonym: "aminophosphonate metabolic process" []
xref_analog: GO:0033051
is_a: IEV:0001557 ! Amino acid derivative metabolism

[Term]
id: IEV:0001468
name: Selenoamino acid metabolism
xref_analog: KEGG:map00450
is_a: IEV:0001557 ! Amino acid derivative metabolism

[Term]
id: IEV:0001469
name: Cyanoamino acid metabolism
def: "The chemical reactions and pathways involving cyanoamino acids, amino acid derivatives that contain a cyanide group." [GO:0033052]
exact_synonym: "cyanoamino acid metabolic process" []
xref_analog: GO:0033052
xref_analog: KEGG:map00460
is_a: IEV:0001557 ! Amino acid derivative metabolism

[Term]
id: IEV:0001470
name: D-Glutamine and D-glutamate metabolism
def: "D-glutamine metabolism:The chemical reactions and pathways involving D-glutamine, the D-enantiomer of the amino acid glutamine, i.e. (2R)-2,5-diamino-5-oxopentanoic acid.\nD-glutamate metabolism:The chemical reactions and pathways involving D-glutamate, the D-enantiomer of the amino acid glutamate, i.e. (2R)-2-aminopentanedioic acid." [GO:0033053, GO:0033054]
xref_analog: GO:0033053
xref_analog: GO:0033054
xref_analog: KEGG:map00471
is_a: IEV:0001410 ! Alanine and aspartate metabolism

[Term]
id: IEV:0001471
name: D-Arginine and D-ornithine metabolism
def: "D-arginine metabolism:The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid.\nD-ornithine metabolism:The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid." [GO:0033055, GO:0033056]
xref_analog: GO:0033055
xref_analog: GO:0033056
xref_analog: KEGG:map00472
is_a: IEV:0001410 ! Alanine and aspartate metabolism

[Term]
id: IEV:0001472
name: D-Alanine metabolism
def: "The chemical reactions and pathways involving D-alanine, the dextrorotatory isomer of the amino acid alanine." [GO:0046436]
exact_synonym: "D-alanine metabolic process" []
xref_analog: GO:0046436
xref_analog: KEGG:map00473
is_a: IEV:0001410 ! Alanine and aspartate metabolism

[Term]
id: IEV:0001473
name: Glutathione metabolism
def: "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [GO:0006749]
exact_synonym: "glutathione metabolic process" []
xref_analog: GO:0006749
xref_analog: KEGG:map00480
is_a: IEV:0001438 ! Sulfur metabolism
is_a: IEV:0001555 ! Metabolism of Cofactors and Vitamins
is_a: IEV:0001557 ! Amino acid derivative metabolism

[Term]
id: IEV:0001474
name: N-Glycan biosynthesis
xref_analog: KEGG:map00510
is_a: IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001475
name: High-mannose type N-glycan biosynthesis
xref_analog: KEGG:map00513
is_a: IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001476
name: N-Glycan degradation
xref_analog: KEGG:map00511
is_a: IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001477
name: O-Glycan biosynthesis
xref_analog: KEGG:map00512
is_a: IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001478
name: Chondroitin sulfate biosynthesis
def: "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GO:0030206]
exact_synonym: "chondroitin sulfate anabolism" []
exact_synonym: "chondroitin sulfate biosynthetic process" []
exact_synonym: "chondroitin sulfate formation" []
exact_synonym: "chondroitin sulfate synthesis" []
exact_synonym: "chondroitin sulphate biosynthesis" []
xref_analog: GO:0030206
xref_analog: KEGG:map00532
is_a: IEV:0001438 ! Sulfur metabolism
is_a: IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001479
name: CD28 signaling
exact_synonym: "CD28 Costimulation" [PubMed:12121659]
xref_analog: PubMed:12121659
is_a: IEV:0000543 ! Positive regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0001842 ! Signaling pathway
is_a: IEV:0002201 ! Positive regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)

[Term]
id: IEV:0001480
name: Phosphorylation of CD28 by Src family in cytosol
xref_analog: IMR:0000211
xref_analog: IMR:0000473
xref_analog: PubMed:12121659
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001479 ! CD28 signaling

[Term]
id: IEV:0001481
name: Phosphorylation of CD28 by Lck in cytosol
xref_analog: IMR:0000473
xref_analog: IMR:0100353
xref_analog: PubMed:12121659
is_a: IEV:0001480 ! Phosphorylation of CD28 by Src family in cytosol

[Term]
id: IEV:0001482
name: Phosphorylation of CD28 by Fyn in cytosol
xref_analog: IMR:0000473
xref_analog: IMR:0100352
xref_analog: PubMed:12121659
is_a: IEV:0001480 ! Phosphorylation of CD28 by Src family in cytosol

[Term]
id: IEV:0001483
name: Binding of CD28 and PI3K in cytosol
xref_analog: IMR:0000265
xref_analog: IMR:0000473
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001479 ! CD28 signaling

[Term]
id: IEV:0001484
name: AKT(PKB) activation signaling
exact_synonym: "PI3K-AKT signaling" [PubMed:10485710]
xref_analog: PubMed:10485710
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0000112 ! AKT(PKB)-TOR signaling
relationship: part_of IEV:0000166 ! AKT(PKB)-Bad signaling
relationship: part_of IEV:0001479 ! CD28 signaling
relationship: part_of IEV:0001707 ! AKT(PKB)-caspase signaling
relationship: part_of IEV:0001709 ! AKT(PKB)-FOXO signaling
relationship: part_of IEV:0001727 ! AKT(PKB)-IKK signaling
relationship: part_of IEV:0001745 ! AKT(PKB)-GSK3beta signaling

[Term]
id: IEV:0001485
name: Regulation of AKT(PKB) activation signaling
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0001484 ! AKT(PKB) activation signaling

[Term]
id: IEV:0001486
name: Negative regulation of AKT(PKB) activation signaling
is_a: IEV:0001485 ! Regulation of AKT(PKB) activation signaling
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0001484 ! AKT(PKB) activation signaling

[Term]
id: IEV:0001487
name: Positive regulation of AKT(PKB) activation signaling
is_a: IEV:0001485 ! Regulation of AKT(PKB) activation signaling
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0001484 ! AKT(PKB) activation signaling

[Term]
id: IEV:0001488
name: Dephosphorylation of PIP3 by PTEN in plasma membrane
xref_analog: IMR:0001352
xref_analog: IMR:0100701
is_a: IEV:0000414 ! Dephosphorylation in plasma membrane
relationship: part_of IEV:0001858 ! Negative regulation of (phosphorylation of PIP2) in AKT(PKB) activation signaling

[Term]
id: IEV:0001489
name: Keratan sulfate biosynthesis
def: "The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GO:0018146]
exact_synonym: "keratan sulfate anabolism" []
exact_synonym: "keratan sulfate biosynthetic process" []
exact_synonym: "keratan sulfate formation" []
exact_synonym: "keratan sulfate synthesis" []
exact_synonym: "keratan sulphate biosynthesis" []
exact_synonym: "keratan sulphate biosynthetic process" []
xref_analog: GO:0018146
xref_analog: KEGG:map00533
is_a: IEV:0001438 ! Sulfur metabolism
is_a: IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001490
name: Glycosaminoglycan degradation
def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [GO:0006027]
exact_synonym: "glycosaminoglycan breakdown" []
exact_synonym: "glycosaminoglycan catabolic process" []
exact_synonym: "glycosaminoglycan catabolism" []
xref_analog: GO:0006027
xref_analog: KEGG:map00531
is_a: IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001491
name: Lipopolysaccharide biosynthesis
def: "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GO:0009103]
exact_synonym: "lipopolysaccharide anabolism" []
exact_synonym: "lipopolysaccharide biosynthetic process" []
exact_synonym: "lipopolysaccharide formation" []
exact_synonym: "lipopolysaccharide synthesis" []
xref_analog: GO:0009103
xref_analog: KEGG:map00540
is_a: IEV:0001553 ! Lipid Metabolism
is_a: IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001492
name: Peptidoglycan biosynthesis
def: "The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [GO:0009252]
exact_synonym: "murein biosynthesis" []
exact_synonym: "murein biosynthetic process" []
exact_synonym: "peptidoglycan anabolism" []
exact_synonym: "peptidoglycan biosynthetic process" []
exact_synonym: "peptidoglycan formation" []
exact_synonym: "peptidoglycan synthesis" []
xref_analog: GO:0009252
xref_analog: KEGG:map00550
is_a: IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001493
name: Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
def: "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GO:0006506]
exact_synonym: "glycosylphosphatidylinositol biosynthesis" []
exact_synonym: "glycosylphosphatidylinositol biosynthetic process" []
exact_synonym: "GPI anchor anabolism" []
exact_synonym: "GPI anchor biosynthetic process" []
exact_synonym: "GPI anchor formation" []
exact_synonym: "GPI anchor synthesis" []
xref_analog: GO:0006506
xref_analog: KEGG:map00563
is_a: IEV:0001448 ! Glycerophospholipid metabolism

[Term]
id: IEV:0001494
name: Sphingolipid metabolism
def: "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GO:0006665]
exact_synonym: "sphingolipid metabolic process" []
xref_analog: GO:0006665
xref_analog: KEGG:map00600
is_a: IEV:0001553 ! Lipid Metabolism

[Term]
id: IEV:0001495
name: Glycosphingolipid biosynthesis-lactoseries
xref_analog: KEGG:map00601
is_a: IEV:0001494 ! Sphingolipid metabolism

[Term]
id: IEV:0001496
name: Glycosphingolipid biosynthesis-neo-lactoseries
xref_analog: KEGG:map00601
is_a: IEV:0001494 ! Sphingolipid metabolism

[Term]
id: IEV:0001497
name: Glycosphingolipid biosynthesis-globoseries
def: "The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1,3)-Gal-alpha(1,4)Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes." [GO:0001575]
exact_synonym: "globoside metabolic process" []
exact_synonym: "globoside metabolism" []
xref_analog: GO:0001575
xref_analog: KEGG:map00603
is_a: IEV:0001494 ! Sphingolipid metabolism

[Term]
id: IEV:0001498
name: Glycosphingolipid biosynthesis-ganglioseries
def: "The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [GO:0001574]
exact_synonym: "ganglioside anabolism" []
exact_synonym: "ganglioside biosynthesis" []
exact_synonym: "ganglioside biosynthetic process" []
exact_synonym: "ganglioside formation" []
exact_synonym: "ganglioside synthesis" []
xref_analog: GO:0001574
xref_analog: KEGG:map00604
is_a: IEV:0001494 ! Sphingolipid metabolism

[Term]
id: IEV:0001499
name: Biosynthesis of vancomycin group antibiotics
xref_analog: KEGG:map01055
is_a: IEV:0001559 ! Polyketide biosynthesis

[Term]
id: IEV:0001500
name: Biosynthesis of 12-, 14- and 16-membered macrolides
xref_analog: KEGG:map00522
is_a: IEV:0001559 ! Polyketide biosynthesis

[Term]
id: IEV:0001501
name: Biosynthesis of ansamycins
def: "The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity." [GO:0033070]
exact_synonym: "ansamycin anabolism" []
exact_synonym: "ansamycin biosynthesis" []
exact_synonym: "ansamycin biosynthetic process" []
exact_synonym: "ansamycin formation" []
exact_synonym: "ansamycin synthesis" []
xref_analog: GO:0033070
xref_analog: KEGG:map01051
is_a: IEV:0001559 ! Polyketide biosynthesis
is_a: IEV:0003811 ! Alcohol metabolism

[Term]
id: IEV:0001502
name: Biosynthesis of type II polyketide backbone
xref_analog: KEGG:map01056
is_a: IEV:0001559 ! Polyketide biosynthesis

[Term]
id: IEV:0001503
name: Biosynthesis of type II polyketide products
xref_analog: KEGG:map01057
is_a: IEV:0001559 ! Polyketide biosynthesis

[Term]
id: IEV:0001504
name: Polyketide sugar unit biosynthesis
xref_analog: KEGG:map00523
is_a: IEV:0001559 ! Polyketide biosynthesis

[Term]
id: IEV:0001505
name: Receptor internalization
def: "The process by which cell surface receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation; serves as a mechanism to downregulate receptor signaling." [GO:0031623]
xref_analog: GO:0031623
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0001506
name: Biosynthesis of siderophore group nonribosomal peptides
xref_analog: KEGG:map01053
is_a: IEV:0001559 ! Polyketide biosynthesis

[Term]
id: IEV:0001507
name: Thiamine metabolism
def: "The chemical reactions and pathways involving thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GO:0006772]
exact_synonym: "thiamin metabolic process" []
exact_synonym: "thiamin metabolism" []
exact_synonym: "thiamine metabolic process" []
exact_synonym: "vitamin B1 metabolic process" []
exact_synonym: "vitamin B1 metabolism" []
xref_analog: GO:0006772
xref_analog: KEGG:map00730
is_a: IEV:0001438 ! Sulfur metabolism
is_a: IEV:0001555 ! Metabolism of Cofactors and Vitamins

[Term]
id: IEV:0001508
name: Riboflavin metabolism
def: "The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GO:0006771]
exact_synonym: "riboflavin metabolic process" []
exact_synonym: "vitamin B2 metabolic process" []
exact_synonym: "vitamin B2 metabolism" []
exact_synonym: "vitamin G metabolic process" []
exact_synonym: "vitamin G metabolism" []
xref_analog: GO:0006771
xref_analog: KEGG:map00740
is_a: IEV:0001555 ! Metabolism of Cofactors and Vitamins

[Term]
id: IEV:0001509
name: Vitamin B6 metabolism
def: "The chemical reactions and pathways involving any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GO:0042816]
exact_synonym: "vitamin B6 metabolic process" []
xref_analog: GO:0042816
xref_analog: KEGG:map00750
is_a: IEV:0001555 ! Metabolism of Cofactors and Vitamins

[Term]
id: IEV:0001510
name: Nicotinate and nicotinamide metabolism
def: "Nicotinamide metabolism: The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms." [GO:0006769]
xref_analog: GO:0006769
xref_analog: GO:0046497
xref_analog: KEGG:map00760
is_a: IEV:0001554 ! Nucleotide Metabolism
is_a: IEV:0001555 ! Metabolism of Cofactors and Vitamins
is_a: IEV:0003813 ! Amide metabolism

[Term]
id: IEV:0001511
name: Pantothenate biosynthesis
def: "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GO:0015940]
exact_synonym: "pantothenate anabolism" []
exact_synonym: "pantothenate biosynthetic process" []
exact_synonym: "pantothenate formation" []
exact_synonym: "pantothenate synthesis" []
exact_synonym: "vitamin B5 biosynthesis" []
exact_synonym: "vitamin B5 biosynthetic process" []
xref_analog: GO:0015940
xref_analog: KEGG:map00770
is_a: IEV:0001555 ! Metabolism of Cofactors and Vitamins
is_a: IEV:0001557 ! Amino acid derivative metabolism

[Term]
id: IEV:0001512
name: Biotin metabolism
def: "The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GO:0006768]
exact_synonym: "biotin metabolic process" []
exact_synonym: "vitamin B7 metabolic process" []
exact_synonym: "vitamin B7 metabolism" []
exact_synonym: "vitamin H metabolic process" []
exact_synonym: "vitamin H metabolism" []
xref_analog: GO:0006768
xref_analog: KEGG:map00780
is_a: IEV:0001438 ! Sulfur metabolism
is_a: IEV:0001555 ! Metabolism of Cofactors and Vitamins
is_a: IEV:0003810 ! Carboxylic acid metabolism
is_a: IEV:0003813 ! Amide metabolism

[Term]
id: IEV:0001514
name: Folate metabolism
alt_id: IEV:0001513
def: "The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GO:0046655]
exact_synonym: "folate metabolic process" []
exact_synonym: "folic acid metabolic process" []
exact_synonym: "folic acid metabolism" []
exact_synonym: "vitamin B9 metabolic process" []
exact_synonym: "vitamin B9 metabolism" []
exact_synonym: "vitamin M metabolic process" []
exact_synonym: "vitamin M metabolism" []
xref_analog: GO:0046655
xref_analog: KEGG:map00670
xref_analog: KEGG:map00790
is_a: IEV:0001555 ! Metabolism of Cofactors and Vitamins
is_a: IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001515
name: Retinol metabolism
def: "The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GO:0042572]
exact_synonym: "retinol metabolic process" []
exact_synonym: "vitamin A1 alcohol metabolic process" []
exact_synonym: "vitamin A1 alcohol metabolism" []
exact_synonym: "vitamin A1 metabolic process" []
exact_synonym: "vitamin A1 metabolism" []
xref_analog: GO:0042572
xref_analog: KEGG:map00830
is_a: IEV:0001553 ! Lipid Metabolism
is_a: IEV:0001555 ! Metabolism of Cofactors and Vitamins

[Term]
id: IEV:0001516
name: Porphyrin and chlorophyll metabolism
def: "Porphyrin metabolism: The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.\nChlorophyll metabolism: The chemical reactions and pathways involving chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GO:0006778, GO:0015994]
xref_analog: GO:0006778
xref_analog: GO:0015994
xref_analog: KEGG:map00860
is_a: IEV:0001555 ! Metabolism of Cofactors and Vitamins

[Term]
id: IEV:0001517
name: Ubiquinone biosynthesis
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GO:0006744]
exact_synonym: "coenzyme Q biosynthesis" []
exact_synonym: "coenzyme Q biosynthetic process" []
exact_synonym: "ubiquinone anabolism" []
exact_synonym: "ubiquinone biosynthetic process" []
exact_synonym: "ubiquinone formation" []
exact_synonym: "ubiquinone synthesis" []
xref_analog: GO:0006744
xref_analog: KEGG:map00130
is_a: IEV:0001555 ! Metabolism of Cofactors and Vitamins

[Term]
id: IEV:0001518
name: Terpenoid biosynthesis
def: "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GO:0016114]
exact_synonym: "terpenoid anabolism" []
exact_synonym: "terpenoid biosynthetic process" []
exact_synonym: "terpenoid formation" []
exact_synonym: "terpenoid synthesis" []
xref_analog: GO:0016114
xref_analog: KEGG:map00900
is_a: IEV:0001553 ! Lipid Metabolism
is_a: IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001519
name: Monoterpenoid biosynthesis
def: "The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton." [GO:0016099]
exact_synonym: "monoterpenoid anabolism" []
exact_synonym: "monoterpenoid biosynthetic process" []
exact_synonym: "monoterpenoid formation" []
exact_synonym: "monoterpenoid synthesis" []
xref_analog: GO:0016099
xref_analog: KEGG:map00902
is_a: IEV:0001553 ! Lipid Metabolism
is_a: IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001520
name: Limonene and pinene degradation
def: "Limonene degradation: The chemical reactions and pathways resulting in the breakdown of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene. \nalpha-pinene degradation: The chemical reactions and pathways resulting in the breakdown of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature." [GO:0046249, GO:0046251]
xref_analog: GO:0046249
xref_analog: GO:0046251
xref_analog: KEGG:map00903
is_a: IEV:0001553 ! Lipid Metabolism
is_a: IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001521
name: Diterpenoid biosynthesis
def: "The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units." [GO:0016102]
exact_synonym: "diterpenoid anabolism" []
exact_synonym: "diterpenoid biosynthetic process" []
exact_synonym: "diterpenoid formation" []
exact_synonym: "diterpenoid synthesis" []
xref_analog: GO:0016102
xref_analog: KEGG:map00904
is_a: IEV:0001518 ! Terpenoid biosynthesis

[Term]
id: IEV:0001522
name: Indole and ipecac alkaloid biosynthesis
def: "Indole biosynthesis: The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [GO:0042432]
xref_analog: GO:0042432
xref_analog: KEGG:map00901
is_a: IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001523
name: Stilbene, coumarine and lignin biosynthesis
def: "Stilbene biosynthesis: The chemical reactions and pathways resulting in the formation of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA. \nCoumarin biosynthesis: The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids. Lignin biosynthesis: The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers." [GO:0009805, GO:0009809, GO:0009811]
xref_analog: GO:0009805
xref_analog: GO:0009809
xref_analog: GO:0009811
is_a: IEV:0001557 ! Amino acid derivative metabolism
is_a: IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001524
name: Flavonoid biosynthesis
def: "The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GO:0009813]
exact_synonym: "flavonoid anabolism" []
exact_synonym: "flavonoid biosynthetic process" []
exact_synonym: "flavonoid formation" []
exact_synonym: "flavonoid synthesis" []
xref_analog: GO:0009813
xref_analog: KEGG:map00941
is_a: IEV:0001557 ! Amino acid derivative metabolism
is_a: IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001525
name: Alkaloid biosynthesis
alt_id: IEV:0001526
def: "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases)." [GO:0009821]
exact_synonym: "alkaloid anabolism" []
exact_synonym: "alkaloid biosynthetic process" []
exact_synonym: "alkaloid formation" []
exact_synonym: "alkaloid synthesis" []
xref_analog: GO:0009821
xref_analog: KEGG:map00950
xref_analog: KEGG:map00960
xref_analog: KEGG:map01058
is_a: IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001527
name: Penicillins and cephalosporins biosynthesis
def: "Penicillin biosynthesis: The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Cephalosporin biosynthesis: The formation from simpler components of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [GO:0042318, GO:0043646]
xref_analog: GO:0042318
xref_analog: GO:0043646
xref_analog: KEGG:map00311
is_a: IEV:0001438 ! Sulfur metabolism
is_a: IEV:0001560 ! Biosynthesis of Secondary Metabolites
is_a: IEV:0003813 ! Amide metabolism

[Term]
id: IEV:0001528
name: beta-Lactam resistanse
xref_analog: KEGG:map00312
is_a: IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001529
name: Streptomycin biosynthesis
def: "The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GO:0019872]
exact_synonym: "streptomycin anabolism" []
exact_synonym: "streptomycin biosynthetic process" []
exact_synonym: "streptomycin formation" []
exact_synonym: "streptomycin synthesis" []
xref_analog: GO:0019872
xref_analog: KEGG:map00521
is_a: IEV:0001422 ! Carbohydrate Metabolism
is_a: IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001530
name: Tetracycline biosynthesis
def: "The formation from simpler components of tetracycline, a broad spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GO:0043644]
exact_synonym: "tetracyclin biosynthesis" []
exact_synonym: "tetracycline biosynthetic process" []
xref_analog: GO:0043644
xref_analog: KEGG:map00253
is_a: IEV:0001560 ! Biosynthesis of Secondary Metabolites
is_a: IEV:0003810 ! Carboxylic acid metabolism

[Term]
id: IEV:0001531
name: Clavulanic acid biosynthesis
def: "The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [GO:0033050]
exact_synonym: "clavulanic acid anabolism" []
exact_synonym: "clavulanic acid biosynthetic process" []
exact_synonym: "clavulanic acid formation" []
exact_synonym: "clavulanic acid synthesis" []
xref_analog: GO:0033050
xref_analog: KEGG:map00331
is_a: IEV:0001560 ! Biosynthesis of Secondary Metabolites
is_a: IEV:0003813 ! Amide metabolism

[Term]
id: IEV:0001532
name: Puromycin biosynthesis
def: "The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [GO:0043638]
exact_synonym: "puromycin biosynthetic process" []
xref_analog: GO:0043638
xref_analog: KEGG:map00231
is_a: IEV:0001560 ! Biosynthesis of Secondary Metabolites
is_a: IEV:0003814 ! Nucleobase, nucleoside, nucleotide and nucleic acid metabolism

[Term]
id: IEV:0001533
name: Novobiocin biosynthesis
def: "The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [GO:0043642]
exact_synonym: "novobiocin biosynthetic process" []
xref_analog: GO:0043642
xref_analog: KEGG:map00401
is_a: IEV:0001422 ! Carbohydrate Metabolism
is_a: IEV:0001557 ! Amino acid derivative metabolism
is_a: IEV:0001560 ! Biosynthesis of Secondary Metabolites
is_a: IEV:0003813 ! Amide metabolism

[Term]
id: IEV:0001534
name: Caprolactam degradation
def: "The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid." [GO:0019384]
exact_synonym: "caprolactam breakdown" []
exact_synonym: "caprolactam catabolic process" []
exact_synonym: "caprolactam catabolism" []
xref_analog: GO:0019384
xref_analog: KEGG:map00930
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism
is_a: IEV:0003813 ! Amide metabolism

[Term]
id: IEV:0001535
name: Biphenyl degradation
def: "The chemical reactions and pathways resulting in the breakdown of biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs)." [GO:0070980]
exact_synonym: "biphenyl breakdown" []
exact_synonym: "biphenyl catabolic process" []
exact_synonym: "biphenyl catabolism" []
xref_analog: GO:0070980
xref_analog: KEGG:map00621
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001536
name: Toluene and xylene degradation
def: "Toluene degradation: The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products.\nXylene degradation: The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GO:0042184, GO:0042203]
xref_analog: GO:0042184
xref_analog: GO:0042203
xref_analog: KEGG:map00622
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001537
name: gamma-Hexachlorocyclohexane degradation
xref_analog: GO:0018919
xref_analog: KEGG:map00361
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001538
name: 3-Chloroacrylic acid degradation
xref_analog: GO:0018888
xref_analog: KEGG:map00641
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001539
name: 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane degradation
def: "The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GO:0042188]
exact_synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane breakdown" []
exact_synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process" []
exact_synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolism" []
exact_synonym: "DDT catabolic process" []
exact_synonym: "DDT catabolism" []
xref_analog: GO:0042188
xref_analog: KEGG:map00351
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001540
name: 2,4-Dichlorobenzoate degradation
def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GO:0046298]
exact_synonym: "2,4-dichlorobenzoate breakdown" []
exact_synonym: "2,4-dichlorobenzoate catabolic process" []
exact_synonym: "2,4-dichlorobenzoate catabolism" []
xref_analog: GO:0046298
xref_analog: KEGG:map00623
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism
is_a: IEV:0003810 ! Carboxylic acid metabolism

[Term]
id: IEV:0001541
name: 1,2-Dichloroethane degradation
def: "The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GO:0019260]
exact_synonym: "1,2-dichloroethane breakdown" []
exact_synonym: "1,2-dichloroethane catabolic process" []
exact_synonym: "1,2-dichloroethane catabolism" []
xref_analog: GO:0019260
xref_analog: KEGG:map00631
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001542
name: Tetrachloroethene degradation
def: "The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines." [GO:0019337]
exact_synonym: "tetrachloroethene catabolic process" []
exact_synonym: "tetrachloroethene catabolism" []
exact_synonym: "tetrachloroethylene breakdown" []
exact_synonym: "tetrachloroethylene catabolic process" []
exact_synonym: "tetrachloroethylene catabolism" []
exact_synonym: "tetrachloroethylene degradation" []
xref_analog: GO:0019337
xref_analog: KEGG:map00625
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001543
name: Styrene degradation
def: "The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene." [GO:0042207]
exact_synonym: "styrene breakdown" []
exact_synonym: "styrene catabolic process" []
exact_synonym: "styrene catabolism" []
xref_analog: GO:0042207
xref_analog: KEGG:map00643
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001544
name: 1,4-Dichlorobenzene degradation
def: "The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring." [GO:0019261]
exact_synonym: "1,4-dichlorobenzene breakdown" []
exact_synonym: "1,4-dichlorobenzene catabolic process" []
exact_synonym: "1,4-dichlorobenzene catabolism" []
xref_analog: GO:0019261
xref_analog: KEGG:map00627
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001545
name: Nitrobenzene degradation
xref_analog: GO:0018916
xref_analog: KEGG:map00626
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001546
name: Ethylbenzene degradation
def: "The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen." [GO:0010130]
xref_analog: GO:0010130
xref_analog: KEGG:map00642
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001547
name: Fluorene degradation
def: "The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [GO:0019429]
exact_synonym: "fluorene breakdown" []
exact_synonym: "fluorene catabolic process" []
exact_synonym: "fluorene catabolism" []
xref_analog: GO:0019429
xref_analog: KEGG:map00628
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001548
name: Carbazole degradation
def: "The chemical reactions and pathways resulting in the breakdown of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GO:0046232]
exact_synonym: "carbazole breakdown" []
exact_synonym: "carbazole catabolic process" []
exact_synonym: "carbazole catabolism" []
xref_analog: GO:0046232
xref_analog: KEGG:map00629
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001549
name: Benzoate degradation via CoA ligation
def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway." [GO:0010128]
exact_synonym: "anaerobic benzoate breakdown" []
exact_synonym: "anaerobic benzoate catabolic process" []
exact_synonym: "anaerobic benzoate catabolism" []
exact_synonym: "anaerobic benzoate degradation" []
exact_synonym: "benzoate catabolic process via CoA ligation" []
xref_analog: GO:0010128
xref_analog: KEGG:map00632
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism
is_a: IEV:0003810 ! Carboxylic acid metabolism

[Term]
id: IEV:0001550
name: Benzoate degradation via hydroxylation
def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol." [GO:0043640]
exact_synonym: "benzoate breakdown via hydroxylation" []
exact_synonym: "benzoate catabolic process via hydroxylation" []
xref_analog: GO:0043640
xref_analog: KEGG:map00362
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism
is_a: IEV:0003810 ! Carboxylic acid metabolism

[Term]
id: IEV:0001551
name: Atrazine degradation
def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide." [GO:0019381]
exact_synonym: "atrazine breakdown" []
exact_synonym: "atrazine catabolic process" []
exact_synonym: "atrazine catabolism" []
xref_analog: GO:0019381
xref_analog: KEGG:map00791
is_a: IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001552
name: Energy Metabolism
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001553
name: Lipid Metabolism
def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GO:0006629]
exact_synonym: "lipid metabolic process" []
xref_analog: GO:0006629
xref_analog: KEGG:map01130
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001554
name: Nucleotide Metabolism
def: "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GO:0009117]
exact_synonym: "nucleotide metabolic process" []
xref_analog: GO:0009117
is_a: IEV:0003814 ! Nucleobase, nucleoside, nucleotide and nucleic acid metabolism

[Term]
id: IEV:0001555
name: Metabolism of Cofactors and Vitamins
def: "Cofactor metabolism: The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.\nVitamin metabolism: The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GO:0006766, GO:0051186]
xref_analog: GO:0006766
xref_analog: GO:0051186
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001556
name: Amino Acid Metabolism
def: "The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents." [GO:0006520]
exact_synonym: "amino acid metabolic process" []
xref_analog: GO:0006520
is_a: IEV:0003810 ! Carboxylic acid metabolism
is_a: IEV:0003812 ! Amino acid and derivative metabolism

[Term]
id: IEV:0001557
name: Amino acid derivative metabolism
def: "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents. " [GO:0006575]
xref_analog: GO:0006575
is_a: IEV:0003812 ! Amino acid and derivative metabolism

[Term]
id: IEV:0001558
name: Glycan Biosynthesis and Metabolism
def: "Glycan biosynthesis: The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages.\nGlycan metabolism: The chemical reactions and pathways involving polysaccharides, a polymer of more than 10 monosaccharide residues joined by glycosidic linkages." [GO:0000271, GO:0005976]
xref_analog: GO:0000271
xref_analog: GO:0005976
is_a: IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001559
name: Polyketide biosynthesis
def: "The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty-acid biosynthesis but without the intermediate reductive steps." [GO:0030639]
exact_synonym: "polyketide anabolism" []
exact_synonym: "polyketide biosynthetic process" []
exact_synonym: "polyketide formation" []
exact_synonym: "polyketide synthesis" []
xref_analog: GO:0030639
is_a: IEV:0003810 ! Carboxylic acid metabolism

[Term]
id: IEV:0001560
name: Biosynthesis of Secondary Metabolites
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001561
name: Xenobiotics Biodegradation and Metabolism
def: "Xenobiotic degradation: The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide. \nXenobiotic metabolism: The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GO:0006805, GO:0042178]
xref_analog: GO:0006805
xref_analog: GO:0042178
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001562
name: Osmotic pressure treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0001563
name: Humidity treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0001564
name: High osmotic pressure treatment
is_a: IEV:0001562 ! Osmotic pressure treatment

[Term]
id: IEV:0001565
name: Heat shock treatment
is_a: IEV:0000379 ! Heat treatment

[Term]
id: IEV:0001566
name: Anticancer drug medication
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0001567
name: Protein synthesis inhibitor medication
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0001568
name: Ultraviolet irradiation
is_a: IEV:0000373 ! Wavelength of light treatment

[Term]
id: IEV:0001569
name: Cyclohexemide medication
is_a: IEV:0001567 ! Protein synthesis inhibitor medication

[Term]
id: IEV:0001570
name: Proteasome inhibitor medication
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0001571
name: Transcription inhibitor medication
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0001572
name: DRB medication
is_a: IEV:0001571 ! Transcription inhibitor medication

[Term]
id: IEV:0001573
name: Hydrogen peroxide treatment
is_a: IEV:0000043 ! Inorganic chemical treatment

[Term]
id: IEV:0001574
name: Abscisic acid stimulus
is_a: IEV:0000294 ! Plant hormone medication

[Term]
id: IEV:0001575
name: Auxin stimulus
is_a: IEV:0000294 ! Plant hormone medication

[Term]
id: IEV:0001576
name: Sorbitol treatment
is_a: IEV:0000064 ! Organic chemical treatment
is_a: IEV:0001564 ! High osmotic pressure treatment

[Term]
id: IEV:0001577
name: Brassinosteroid stimulus
is_a: IEV:0000294 ! Plant hormone medication

[Term]
id: IEV:0001578
name: Cytokinin stimulus
is_a: IEV:0000294 ! Plant hormone medication

[Term]
id: IEV:0001579
name: Ethylene stimulus
is_a: IEV:0000294 ! Plant hormone medication

[Term]
id: IEV:0001580
name: Gibberellic acid stimulus
is_a: IEV:0000294 ! Plant hormone medication

[Term]
id: IEV:0001581
name: Carbohydrate treatment
is_a: IEV:0000064 ! Organic chemical treatment

[Term]
id: IEV:0001582
name: Hexose treatment
is_a: IEV:0001581 ! Carbohydrate treatment

[Term]
id: IEV:0001583
name: Sucrose treatment
is_a: IEV:0001581 ! Carbohydrate treatment

[Term]
id: IEV:0001584
name: Fructose treatment
is_a: IEV:0001581 ! Carbohydrate treatment

[Term]
id: IEV:0001585
name: Glucose treatment
is_a: IEV:0001581 ! Carbohydrate treatment

[Term]
id: IEV:0001586
name: Anisomycin medication
is_a: IEV:0001567 ! Protein synthesis inhibitor medication

[Term]
id: IEV:0001587
name: Puromycin medication
is_a: IEV:0001567 ! Protein synthesis inhibitor medication

[Term]
id: IEV:0001588
name: Actinomycin medication
is_a: IEV:0001571 ! Transcription inhibitor medication

[Term]
id: IEV:0001589
name: Src family activation signaling
xref_analog: PubMed:15034556
is_a: IEV:0000458 ! Protein activation/inactivation signaling

[Term]
id: IEV:0001590
name: Src family inactivation signaling
xref_analog: PubMed:11781344
is_a: IEV:0000458 ! Protein activation/inactivation signaling
is_a: IEV:0000559 ! Negative regulation of Src family activation signaling

[Term]
id: IEV:0001591
name: Phosphorylation of Lck by non-receptor kinase and inactive conformational change in cytosol
xref_analog: IMR:0000682
xref_analog: IMR:0100353
xref_analog: PubMed:15034556
is_a: IEV:0001612 ! Phosphorylation of Src family by non-receptor kinase and inactive conformational change in cytosol
relationship: part_of IEV:0001890 ! Lck inactivation signaling (through Csk)

[Term]
id: IEV:0001592
name: Dephosphorylation of Lck_p by PTP in cytosol
exact_synonym: "Dephosphorylation of Lck_p (autophosphorylated) by PTP in cytosol" []
xref_analog: IMR:0000273
xref_analog: IMR:0100353
xref_analog: PubMed:15034556
is_a: IEV:0001611 ! Dephosphorylation of Src family_p by PTP in cytosol
relationship: part_of IEV:0000513 ! Lck inactivation signaling (through PTP)

[Term]
id: IEV:0001593
name: Interaction in the inner space of the nuclear
def: "OBSOLETE: remap to 'Unknown interaction' IEV:0000922." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0001594
name: Dephosphorylation of Fyn_p by PTP in cytosol
exact_synonym: "Dephosphorylation of Fyn_p (autophosphorylated) by PTP in cytosol" []
xref_analog: IMR:0000273
xref_analog: IMR:0100352
xref_analog: PubMed:15034556
is_a: IEV:0001611 ! Dephosphorylation of Src family_p by PTP in cytosol
relationship: part_of IEV:0000558 ! Fyn inactivation signaling (through PTP)

[Term]
id: IEV:0001595
name: Protein involved in DNA fragmentation and chromatin condensation signaling
is_obsolete: true

[Term]
id: IEV:0001596
name: Phosphorylation of Fyn by non-receptor kinase and inactive conformational change in cytosol
xref_analog: IMR:0000682
xref_analog: IMR:0100352
xref_analog: PubMed:15034556
is_a: IEV:0001612 ! Phosphorylation of Src family by non-receptor kinase and inactive conformational change in cytosol
relationship: part_of IEV:0001891 ! Fyn inactivation signaling (through Csk)

[Term]
id: IEV:0001597
name: Phosphorylation of Src family by Csk and inactive conformational change in cytosol
xref_analog: IMR:0000211
xref_analog: PubMed:15034556
is_a: IEV:0001612 ! Phosphorylation of Src family by non-receptor kinase and inactive conformational change in cytosol

[Term]
id: IEV:0001598
name: Dephosphorylation of Fyn_p by PTP and active conformational change in cytosol
exact_synonym: "Dephosphorylation of Fyn_p (phosphorylated in the C-terminal site) by PTP and active conformational change in cytosol" []
xref_analog: IMR:0000273
xref_analog: IMR:0100352
xref_analog: PubMed:15034556
is_a: IEV:0001608 ! Dephosphorylation of Src family_p by PTP and active conformational change in cytosol
relationship: part_of IEV:0000535 ! Fyn activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001599
name: Dephosphorylation of Lck_p by PTP and active conformational change in cytosol
exact_synonym: "Dephosphorylation of Lck_p (phosphorylated in the C-terminal phosphorylation site) by PTP and active conformational change in cytosol" []
xref_analog: IMR:0000273
xref_analog: IMR:0100353
xref_analog: PubMed:15034556
is_a: IEV:0001608 ! Dephosphorylation of Src family_p by PTP and active conformational change in cytosol
relationship: part_of IEV:0000519 ! Lck activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001600
name: Dephosphorylation of Src_p by SHP-1 and active conformational change
exact_synonym: "Dephosphorylation of Src (phosphorylated in the C-terminal site) by SHP-1 and active conformational change" []
xref_analog: IMR:0000275
xref_analog: IMR:0100575
xref_analog: PubMed:15034556
xref_analog: PubMed:9261115
is_a: IEV:0001638 ! Dephosphorylation of Src_p by PTP and active conformational change in cytosol

[Term]
id: IEV:0001601
name: Dephosphorylation of Src_p by SHP-2 and active conformational change
exact_synonym: "Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP1D and active conformational change" []
xref_analog: IMR:0000276
xref_analog: IMR:0100575
xref_analog: PubMed:15034556
xref_analog: PubMed:7478513
is_a: IEV:0001638 ! Dephosphorylation of Src_p by PTP and active conformational change in cytosol

[Term]
id: IEV:0001602
name: EndoG mediated signaling
relationship: part_of IEV:0001017 ! DNA fragmentation during apoptosis
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0001603
name: CAD signaling
relationship: part_of IEV:0000938 ! Caspase cascade (not through mitochondria)
relationship: part_of IEV:0001017 ! DNA fragmentation during apoptosis

[Term]
id: IEV:0001604
name: Gene expression of apoptotic factor by p53
xref_analog: IMR:0100659
is_a: IEV:0001110 ! Gene expression by p53
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0001605
name: Nuclear import of EndoG
xref_analog: UniProt:Q14249
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001602 ! EndoG mediated signaling

[Term]
id: IEV:0001606
name: Src family activation signaling (through autophosphorylation and PTP)
xref_analog: IMR:0000273
is_a: IEV:0001589 ! Src family activation signaling

[Term]
id: IEV:0001607
name: Autophosphorylation of Src family and active conformational change in cytosol
xref_analog: IMR:0000211
xref_analog: PubMed:15034556
is_a: IEV:0000481 ! Autophosphorylation in cytosol
relationship: part_of IEV:0001606 ! Src family activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001608
name: Dephosphorylation of Src family_p by PTP and active conformational change in cytosol
exact_synonym: "Dephosphorylation of Src family (phosphorylated in the C-terminal site) by PTP and active conformational change in cytosol" []
xref_analog: IMR:0000211
xref_analog: IMR:0000273
xref_analog: PubMed:15034556
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0001606 ! Src family activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001609
name: Fyn activation signaling
is_a: IEV:0001589 ! Src family activation signaling

[Term]
id: IEV:0001610
name: Lck activation signaling
is_a: IEV:0001589 ! Src family activation signaling

[Term]
id: IEV:0001611
name: Dephosphorylation of Src family_p by PTP in cytosol
exact_synonym: "Dephosphorylation of Src family (autophosphorylated) by PTP in cytosol" []
xref_analog: IMR:0000211
xref_analog: IMR:0000273
xref_analog: PubMed:15034556
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0001590 ! Src family inactivation signaling

[Term]
id: IEV:0001612
name: Phosphorylation of Src family by non-receptor kinase and inactive conformational change in cytosol
xref_analog: IMR:0000211
xref_analog: IMR:0000682
xref_analog: PubMed:15034556
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001590 ! Src family inactivation signaling

[Term]
id: IEV:0001613
name: Regulation of Fyn activation signaling
is_a: IEV:0000520 ! Regulation of Src family activation signaling
relationship: regulates IEV:0001609 ! Fyn activation signaling

[Term]
id: IEV:0001614
name: Negative regulation of Fyn activation signaling
is_a: IEV:0000559 ! Negative regulation of Src family activation signaling
is_a: IEV:0001613 ! Regulation of Fyn activation signaling
relationship: negatively_regulates IEV:0001609 ! Fyn activation signaling

[Term]
id: IEV:0001615
name: Positive regulation of Fyn activation signaling
is_a: IEV:0000560 ! Positive regulation of Src family activation signaling
is_a: IEV:0001613 ! Regulation of Fyn activation signaling
relationship: positively_regulates IEV:0001609 ! Fyn activation signaling

[Term]
id: IEV:0001616
name: Regulation of Lck activation signaling
is_a: IEV:0000520 ! Regulation of Src family activation signaling
relationship: regulates IEV:0001610 ! Lck activation signaling

[Term]
id: IEV:0001617
name: Negative regulation of Lck activation signaling
is_a: IEV:0000559 ! Negative regulation of Src family activation signaling
is_a: IEV:0001616 ! Regulation of Lck activation signaling
relationship: negatively_regulates IEV:0001610 ! Lck activation signaling

[Term]
id: IEV:0001618
name: Positive regulation of Lck activation signaling
is_a: IEV:0000560 ! Positive regulation of Src family activation signaling
is_a: IEV:0001616 ! Regulation of Lck activation signaling
relationship: positively_regulates IEV:0001610 ! Lck activation signaling

[Term]
id: IEV:0001619
name: Regulation of Src activation signaling
is_a: IEV:0000520 ! Regulation of Src family activation signaling
relationship: regulates IEV:0001222 ! Src activation signaling

[Term]
id: IEV:0001620
name: Negative regulation of Src activation signaling
is_a: IEV:0001619 ! Regulation of Src activation signaling
relationship: negatively_regulates IEV:0001222 ! Src activation signaling

[Term]
id: IEV:0001621
name: Positive regulation of Src activation signaling
is_a: IEV:0001619 ! Regulation of Src activation signaling
relationship: positively_regulates IEV:0001222 ! Src activation signaling

[Term]
id: IEV:0001622
name: Regulation of Src family activation signaling (autophosphorylation and PTP)
xref_analog: IMR:0000273
is_a: IEV:0000520 ! Regulation of Src family activation signaling
relationship: regulates IEV:0001606 ! Src family activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001623
name: Negative regulation of Src family activation signaling (autophosphorylation and PTP)
xref_analog: IMR:0000273
is_a: IEV:0000559 ! Negative regulation of Src family activation signaling
is_a: IEV:0001622 ! Regulation of Src family activation signaling (autophosphorylation and PTP)
relationship: negatively_regulates IEV:0001606 ! Src family activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001624
name: Positive regulation of Src family activation signaling (autophosphorylation and PTP)
xref_analog: IMR:0000273
is_a: IEV:0000560 ! Positive regulation of Src family activation signaling
is_a: IEV:0001622 ! Regulation of Src family activation signaling (autophosphorylation and PTP)
relationship: positively_regulates IEV:0001606 ! Src family activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001625
name: Regulation of src activation signaling (through Estrogen receptor)
is_a: IEV:0001619 ! Regulation of Src activation signaling
relationship: regulates IEV:0001313 ! Src activation signaling (through Estrogen receptor)

[Term]
id: IEV:0001626
name: Negative regulation of src activation signaling (through Estrogen receptor)
is_a: IEV:0001620 ! Negative regulation of Src activation signaling
is_a: IEV:0001625 ! Regulation of src activation signaling (through Estrogen receptor)
relationship: negatively_regulates IEV:0001313 ! Src activation signaling (through Estrogen receptor)

[Term]
id: IEV:0001627
name: Positive regulation of src activation signaling (through Estrogen receptor)
is_a: IEV:0001621 ! Positive regulation of Src activation signaling
is_a: IEV:0001625 ! Regulation of src activation signaling (through Estrogen receptor)
relationship: positively_regulates IEV:0001313 ! Src activation signaling (through Estrogen receptor)

[Term]
id: IEV:0001628
name: Regulation of Fyn activation signaling (through autophosphorylation and PTP)
xref_analog: IMR:0000273
is_a: IEV:0001613 ! Regulation of Fyn activation signaling
relationship: regulates IEV:0000535 ! Fyn activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001629
name: Negative regulation of Fyn activation signaling (through autophosphorylation and PTP)
xref_analog: IMR:0000273
is_a: IEV:0001614 ! Negative regulation of Fyn activation signaling
is_a: IEV:0001628 ! Regulation of Fyn activation signaling (through autophosphorylation and PTP)
relationship: negatively_regulates IEV:0000535 ! Fyn activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001630
name: Positive regulation of Fyn activation signaling (autophosphorylation and PTP)
xref_analog: IMR:0000273
is_a: IEV:0001615 ! Positive regulation of Fyn activation signaling
is_a: IEV:0001628 ! Regulation of Fyn activation signaling (through autophosphorylation and PTP)
relationship: positively_regulates IEV:0000535 ! Fyn activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001631
name: Regulation of Lck activation signaling (autophosphorylation and PTP)
xref_analog: IMR:0000273
is_a: IEV:0001616 ! Regulation of Lck activation signaling
relationship: regulates IEV:0000519 ! Lck activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001632
name: Negative regulation of (dephosphorylation of Lck) Lck activation signaling (autophosphorylation and PTP)
xref_analog: IMR:0000273
is_a: IEV:0001617 ! Negative regulation of Lck activation signaling
is_a: IEV:0001896 ! Negative regulation of Lck activation signaling (autophosphorylation and PTP)

[Term]
id: IEV:0001633
name: Positive regulation of Lck activation signaling (autophosphorylation and PTP)
xref_analog: IMR:0000273
is_a: IEV:0001618 ! Positive regulation of Lck activation signaling
is_a: IEV:0001631 ! Regulation of Lck activation signaling (autophosphorylation and PTP)
relationship: positively_regulates IEV:0000519 ! Lck activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001634
name: Fyn inactivation signaling
is_a: IEV:0001590 ! Src family inactivation signaling

[Term]
id: IEV:0001635
name: Lck inactivation signaling
is_a: IEV:0001590 ! Src family inactivation signaling
is_a: IEV:0001617 ! Negative regulation of Lck activation signaling

[Term]
id: IEV:0001636
name: Src activation signaling (through autophosphorylation and PTP)
xref_analog: IMR:0000273
is_a: IEV:0001222 ! Src activation signaling
is_a: IEV:0001606 ! Src family activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001637
name: Autophosphorylation of Src and active conformational change in cytosol
def: "p416" [PubMed:11804588]
xref_analog: IMR:0100575
xref_analog: PubMed:11804588
xref_analog: PubMed:15034556
is_a: IEV:0001607 ! Autophosphorylation of Src family and active conformational change in cytosol
relationship: part_of IEV:0001636 ! Src activation signaling (through autophosphorylation and PTP)
relationship: part_of IEV:0002081 ! Rap1 activation signaling (through cAMP, PKA, Cbl and C3G)

[Term]
id: IEV:0001638
name: Dephosphorylation of Src_p by PTP and active conformational change in cytosol
exact_synonym: "Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP and active conformational change in cytosol" []
xref_analog: IMR:0000273
xref_analog: IMR:0100575
xref_analog: PubMed:15034556
is_a: IEV:0001608 ! Dephosphorylation of Src family_p by PTP and active conformational change in cytosol
relationship: part_of IEV:0001636 ! Src activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001639
name: Regulation of Src activation signaling (through autophosphorylation and PTP)
xref_analog: IMR:0000273
is_a: IEV:0001619 ! Regulation of Src activation signaling
relationship: regulates IEV:0001636 ! Src activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001640
name: Negative regulation of Src activation signaling (through autophosphorylation and PTP)
xref_analog: IMR:0000273
is_a: IEV:0001620 ! Negative regulation of Src activation signaling
is_a: IEV:0001639 ! Regulation of Src activation signaling (through autophosphorylation and PTP)
relationship: negatively_regulates IEV:0001636 ! Src activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001641
name: Positive regulation of Src activation signaling (through autophosphorylation and PTP)
xref_analog: IMR:0000273
is_a: IEV:0001621 ! Positive regulation of Src activation signaling
is_a: IEV:0001639 ! Regulation of Src activation signaling (through autophosphorylation and PTP)
relationship: positively_regulates IEV:0001636 ! Src activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001642
name: Src inactivation signaling
xref_analog: PubMed:15034556
is_a: IEV:0001590 ! Src family inactivation signaling

[Term]
id: IEV:0001643
name: Dephosphorylation of Src_p by PTP in cytosol
exact_synonym: "Dephosphorylation of Src (autophosphorylated) by PTP in cytosol" []
xref_analog: IMR:0000273
xref_analog: IMR:0100575
xref_analog: PubMed:15034556
is_a: IEV:0001611 ! Dephosphorylation of Src family_p by PTP in cytosol
is_a: IEV:0001892 ! Src inactivation signaling (through PTP)

[Term]
id: IEV:0001644
name: Phosphorylation of Src by non-receptor kinase and inactive conformational change in cytosol
xref_analog: IMR:0000682
xref_analog: IMR:0100575
xref_analog: PubMed:15034556
is_a: IEV:0001612 ! Phosphorylation of Src family by non-receptor kinase and inactive conformational change in cytosol
relationship: part_of IEV:0001893 ! Src inactivation signaling (through non-receptor kinase)

[Term]
id: IEV:0001645
name: Phosphorylation of Src by Csk and inactive conformational change in cytosol
xref_analog: IMR:0000212
xref_analog: IMR:0100575
xref_analog: PubMed:12480346
xref_analog: PubMed:15034556
is_a: IEV:0001597 ! Phosphorylation of Src family by Csk and inactive conformational change in cytosol
is_a: IEV:0001644 ! Phosphorylation of Src by non-receptor kinase and inactive conformational change in cytosol

[Term]
id: IEV:0001646
name: Dephosphorylation of Src_p by PTP alpha and active conformational change
exact_synonym: "Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP alpha and active conformational change" []
xref_analog: IMR:0100575
xref_analog: PubMed:15034556
xref_analog: UniProt:P18433
is_a: IEV:0001638 ! Dephosphorylation of Src_p by PTP and active conformational change in cytosol

[Term]
id: IEV:0001647
name: Dephosphorylation of Src_p by PTP lambda and active conformational change
exact_synonym: "Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP lambda and active conformational change" []
xref_analog: IMR:0100575
xref_analog: PubMed:15034556
xref_analog: UniProt:Q92729
is_a: IEV:0001638 ! Dephosphorylation of Src_p by PTP and active conformational change in cytosol

[Term]
id: IEV:0001648
name: Dephosphorylation of Src_p by PTP1B and active conformational change
exact_synonym: "Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP1B and active conformational change" []
xref_analog: IMR:0100575
xref_analog: PubMed:15034556
xref_analog: UniProt:P18031
is_a: IEV:0001638 ! Dephosphorylation of Src_p by PTP and active conformational change in cytosol

[Term]
id: IEV:0001649
name: Permeabilization of mitochondria and Translocation of EndoG from mitochondria to cytosol
xref_analog: UniProt:Q14249
is_a: IEV:0000985 ! Translocation from mitochondria to cytosol
relationship: part_of IEV:0001602 ! EndoG mediated signaling

[Term]
id: IEV:0001650
name: Gene expression of BAK by p53
xref_analog: IMR:0000452
xref_analog: IMR:0100659
is_a: IEV:0001604 ! Gene expression of apoptotic factor by p53

[Term]
id: IEV:0001651
name: Gene expression of Bid by p53
xref_analog: IMR:0100289
xref_analog: IMR:0100659
is_a: IEV:0001604 ! Gene expression of apoptotic factor by p53

[Term]
id: IEV:0001652
name: Gene expression of NOXA by p53
xref_analog: IMR:0001210
xref_analog: IMR:0100659
is_a: IEV:0001604 ! Gene expression of apoptotic factor by p53

[Term]
id: IEV:0001653
name: Gene expression of PUMA by p53
xref_analog: IMR:0001211
xref_analog: IMR:0100659
is_a: IEV:0001604 ! Gene expression of apoptotic factor by p53

[Term]
id: IEV:0001654
name: Nuclear export of mRNA (BAK)
xref_analog: IMR:0000452
is_a: IEV:0000909 ! Nuclear export of mRNA
relationship: part_of IEV:0001650 ! Gene expression of BAK by p53

[Term]
id: IEV:0001655
name: Nuclear export of mRNA (Bid)
xref_analog: IMR:0100289
is_a: IEV:0000909 ! Nuclear export of mRNA
relationship: part_of IEV:0001651 ! Gene expression of Bid by p53

[Term]
id: IEV:0001656
name: Nuclear export of mRNA (NOXA)
xref_analog: IMR:0001210
is_a: IEV:0000909 ! Nuclear export of mRNA
relationship: part_of IEV:0001652 ! Gene expression of NOXA by p53

[Term]
id: IEV:0001657
name: Nuclear export of mRNA (PUMA)
xref_analog: IMR:0001211
is_a: IEV:0000909 ! Nuclear export of mRNA
relationship: part_of IEV:0001653 ! Gene expression of PUMA by p53

[Term]
id: IEV:0001658
name: Transcription of BAK by p53 in nucleus
xref_analog: IMR:0000452
xref_analog: IMR:0100659
is_a: IEV:0001661 ! Transcription of apoptotic factor by p53 in nucleus
relationship: part_of IEV:0001650 ! Gene expression of BAK by p53

[Term]
id: IEV:0001659
name: Transcription of Bid by p53 in nucleus
xref_analog: IMR:0100289
xref_analog: IMR:0100659
is_a: IEV:0001661 ! Transcription of apoptotic factor by p53 in nucleus
relationship: part_of IEV:0001651 ! Gene expression of Bid by p53

[Term]
id: IEV:0001660
name: Translation of NOXA in cytosol
xref_analog: IMR:0001210
is_a: IEV:0001662 ! Translation of apoptotic factor in cytosol
relationship: part_of IEV:0001652 ! Gene expression of NOXA by p53

[Term]
id: IEV:0001661
name: Transcription of apoptotic factor by p53 in nucleus
xref_analog: IMR:0100659
is_a: IEV:0001144 ! Transcription by p53 in nucleus

[Term]
id: IEV:0001662
name: Translation of apoptotic factor in cytosol
is_a: IEV:0003550 ! Translation in cytosol

[Term]
id: IEV:0001663
name: Translation of BAK in cytosol
xref_analog: IMR:0000452
is_a: IEV:0001662 ! Translation of apoptotic factor in cytosol
relationship: part_of IEV:0001650 ! Gene expression of BAK by p53

[Term]
id: IEV:0001664
name: Translation of Bid in cytosol
xref_analog: IMR:0100289
is_a: IEV:0001662 ! Translation of apoptotic factor in cytosol
relationship: part_of IEV:0001651 ! Gene expression of Bid by p53

[Term]
id: IEV:0001665
name: Translation of PUMA in cytosol
xref_analog: IMR:0001211
is_a: IEV:0001662 ! Translation of apoptotic factor in cytosol
relationship: part_of IEV:0001653 ! Gene expression of PUMA by p53

[Term]
id: IEV:0001666
name: Permeabilization of mitochondria and Translocation of OMI from mitochondria to cytosol
xref_analog: UniProt:O43464
is_a: IEV:0000985 ! Translocation from mitochondria to cytosol
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0001667
name: Bcl-2/Bcl-xL inactivation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0001668
name: Relocation of free Bid to cytosol
xref_analog: IMR:0100289
relationship: part_of IEV:0000941 ! BID activation signaling

[Term]
id: IEV:0001669
name: Positive signal transduction regulation pathway
def: "Any process that activates or increases the frequency, rate or extent of a signaling pathway." [GO:0035468]
xref_analog: GO:0035468
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: positively_regulates IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0001670
name: Negative signal transduction regulation pathway
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway." [GO:0035467]
xref_analog: GO:0035467
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: negatively_regulates IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0001671
name: Negative regulation of PDGF receptor signaling pathway
is_a: IEV:0000835 ! Negative regulation of RTK signaling pathway
is_a: IEV:0001406 ! Regulation of PDGF signaling pathway
relationship: negatively_regulates IEV:0001257 ! PDGF receptor signaling pathway

[Term]
id: IEV:0001672
name: Positive regulation of PDGF signaling pathway
is_a: IEV:0000836 ! Positive regulation of RTK signaling pathway
is_a: IEV:0001406 ! Regulation of PDGF signaling pathway
relationship: positively_regulates IEV:0001257 ! PDGF receptor signaling pathway

[Term]
id: IEV:0001673
name: Negative regulation of Toll-like receptor pathway
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway." [GO:0034122]
exact_synonym: "negative regulation of TLR signaling pathway" []
xref_analog: GO:0034122
is_a: IEV:0001400 ! Regulation of Toll-like receptor pathway
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
relationship: negatively_regulates IEV:0000462 ! Toll-like receptor signaling pathway

[Term]
id: IEV:0001674
name: Positive regulation of Toll-like receptor pathway
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway." [GO:0034123]
exact_synonym: "positive regulation of TLR signaling pathway" []
xref_analog: GO:0034123
is_a: IEV:0001400 ! Regulation of Toll-like receptor pathway
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
relationship: positively_regulates IEV:0000462 ! Toll-like receptor signaling pathway

[Term]
id: IEV:0001675
name: Regulation of Wnt signaling pathway
def: "Any process that modulates the frequency, rate or extent of the activity of the Wnt receptor mediated signal transduction pathway." [GO:0030111]
xref_analog: GO:0030111
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001676
name: Negative regulation of Wnt signaling pathway
def: "Any process that stops, prevents or reduces the rate, frequency or extent of Wnt receptor signaling pathway activity." [GO:0030178]
xref_analog: GO:0030178
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
is_a: IEV:0001675 ! Regulation of Wnt signaling pathway
relationship: negatively_regulates IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001677
name: Positive regulation of Wnt signaling pathway
def: "Any process that activates or increases the rate, frequency or extent of Wnt receptor signaling pathway activity." [GO:0030177]
xref_analog: GO:0030177
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
is_a: IEV:0001675 ! Regulation of Wnt signaling pathway
relationship: positively_regulates IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001678
name: Caloric restriction
xref_analog: PubMed:15205477
is_a: IEV:0001679 ! Caloric treatment
relationship: part_of IEV:0001686 ! Caloric restriction - cell survival signaling

[Term]
id: IEV:0001679
name: Caloric treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0001680
name: Deacetylation of Ku70 by SIRT1 in nucleus
xref_analog: EC:3.5.1.-
xref_analog: IMR:0010335
xref_analog: PubMed:15205477
xref_analog: UniProt:Q96EB6
is_a: IEV:0001683 ! Deacetylation in nucleus
relationship: part_of IEV:0001686 ! Caloric restriction - cell survival signaling

[Term]
id: IEV:0001681
name: Deacetylation
def: "N6-acetyl-L-lysine or S-acetyl-L-cysteine are cleaved and return K or C residues." [MI:0197]
xref_analog: MI:0197
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0001682
name: Deacetylation in cytosol
is_a: IEV:0001681 ! Deacetylation

[Term]
id: IEV:0001683
name: Deacetylation in nucleus
is_a: IEV:0001681 ! Deacetylation

[Term]
id: IEV:0001684
name: Deacetylation in unidentified cellular location
is_a: IEV:0001681 ! Deacetylation

[Term]
id: IEV:0001685
name: Regulation of caloric restriction - cell survival signaling
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0001686 ! Caloric restriction - cell survival signaling

[Term]
id: IEV:0001686
name: Caloric restriction - cell survival signaling
is_a: IEV:0001842 ! Signaling pathway
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0001687
name: Regulation of IGF signaling pathway
def: "Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling." [GO:0043567]
exact_synonym: "regulation of IGF receptor signaling pathway" [GO:0043567]
exact_synonym: "regulation of insulin-like growth factor receptor signaling pathwa" [GO:0043567]
xref_analog: GO:0043567
is_a: IEV:0000834 ! Regulation of RTK signaling pathway
relationship: regulates IEV:0000454 ! IGF signaling pathway

[Term]
id: IEV:0001688
name: Negative regulation of IGF receptor signaling pathway
def: "Any process that stops, prevents or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling." [GO:0043569]
exact_synonym: "negative regulation of insulin-like growth factor receptor signaling pathway" [GO:0043569]
xref_analog: GO:0043569
is_a: IEV:0000835 ! Negative regulation of RTK signaling pathway
is_a: IEV:0001687 ! Regulation of IGF signaling pathway
relationship: negatively_regulates IEV:0000454 ! IGF signaling pathway

[Term]
id: IEV:0001689
name: Positive regulation of IGF signaling pathway
def: "Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling." [GO:0043568]
exact_synonym: "positive regulation of IGF receptor signaling pathway" [GO:0043568]
exact_synonym: "positive regulation of insulin-like growth factor receptor signaling pathway" [GO:0043568]
xref_analog: GO:0043568
is_a: IEV:0000836 ! Positive regulation of RTK signaling pathway
is_a: IEV:0001687 ! Regulation of IGF signaling pathway
relationship: positively_regulates IEV:0000454 ! IGF signaling pathway

[Term]
id: IEV:0001690
name: Negative regulation of caloric restriction - cell survival signaling
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
is_a: IEV:0001685 ! Regulation of caloric restriction - cell survival signaling
relationship: negatively_regulates IEV:0001686 ! Caloric restriction - cell survival signaling

[Term]
id: IEV:0001691
name: Positive regulation of caloric restriction - cell survival signaling
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
is_a: IEV:0001685 ! Regulation of caloric restriction - cell survival signaling
relationship: positively_regulates IEV:0001686 ! Caloric restriction - cell survival signaling

[Term]
id: IEV:0001692
name: Translocation of Bax from mitochondria membrane to cytosol
xref_analog: IMR:0000453
xref_analog: PubMed:15205477
is_a: IEV:0000175 ! Translocation from mitochondria membrane to cytosol
relationship: part_of IEV:0001686 ! Caloric restriction - cell survival signaling

[Term]
id: IEV:0001693
name: Endothelin receptor signaling
xref_analog: PubMed:11585834
is_a: IEV:0000661 ! GPCR signaling pathway
relationship: part_of IEV:0001822 ! Vasoconstriction
relationship: part_of IEV:0001824 ! Smooth muscle cell differentiation

[Term]
id: IEV:0001694
name: Binding of endothelin and endothelin receptor in extracellular
xref_analog: IMR:0100166
xref_analog: UniProt:P24530
xref_analog: UniProt:P25101
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001693 ! Endothelin receptor signaling

[Term]
id: IEV:0001695
name: Regulation of endothelin receptor signaling
exact_synonym: "Regulation of endothelin receptor signaling pathway" []
is_a: IEV:0000668 ! Regulation of heterotrimeric GPCR signaling pathway
relationship: regulates IEV:0001693 ! Endothelin receptor signaling

[Term]
id: IEV:0001696
name: Negative regulation of endothelin receptor signaling
exact_synonym: "Negative regulation of endothelin receptor signaling pathway" []
is_a: IEV:0000669 ! Negative regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0001695 ! Regulation of endothelin receptor signaling
relationship: negatively_regulates IEV:0001693 ! Endothelin receptor signaling

[Term]
id: IEV:0001697
name: Positive regulation of endothelin receptor signaling
exact_synonym: "Positive regulation of endothelin receptor signaling pathway" []
is_a: IEV:0000670 ! Positive regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0001695 ! Regulation of endothelin receptor signaling
relationship: positively_regulates IEV:0001693 ! Endothelin receptor signaling

[Term]
id: IEV:0001698
name: Binding of 14-3-3 and HDAC5/7 in cytosol and/or nucleus
xref_analog: IMR:0000456
xref_analog: IMR:0001171
xref_analog: IMR:0001173
xref_analog: PubMed:11509672
xref_analog: PubMed:11585834
xref_analog: PubMed:15166223
is_a: IEV:0001730 ! Binding in cytosol and/or nucleus
relationship: part_of IEV:0001866 ! HDAC nuclear export signaling

[Term]
id: IEV:0001699
name: AKT signaling
def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B, which occurs as a result of a single trigger reaction or compound." [GO:0043491]
exact_synonym: "AKT signaling cascade" [GO:0043491]
exact_synonym: "PKB signaling cascade" [GO:0043491]
exact_synonym: "protein kinase B signaling cascade" [GO:0043491]
xref_analog: GO:0043491
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0001700
name: Phosphorylation of HDAC5/7 by CaMK in cytosol and/or nucleus
xref_analog: IMR:0001171
xref_analog: IMR:0001173
xref_analog: IMR:0100543
xref_analog: PubMed:11509672
xref_analog: PubMed:11585834
xref_analog: PubMed:15166223
is_a: IEV:0001735 ! Phosphorylation in cytosol and/or nucleus
relationship: part_of IEV:0001866 ! HDAC nuclear export signaling

[Term]
id: IEV:0001701
name: Dephosphorylation of HDAC5/7 by protein phosphatase in cytosol
xref_analog: IMR:0000272
xref_analog: IMR:0001171
xref_analog: IMR:0001173
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0001865 ! HDAC nuclear import signaling

[Term]
id: IEV:0001702
name: Nuclear export of 14-3-3:HDAC5/7:Crm1
xref_analog: IMR:0000456
xref_analog: IMR:0001090
xref_analog: IMR:0001171
xref_analog: IMR:0001173
xref_analog: PubMed:11509672
xref_analog: PubMed:11585834
is_a: IEV:0000019 ! Nuclear export
relationship: part_of IEV:0001866 ! HDAC nuclear export signaling

[Term]
id: IEV:0001703
name: Binding of HDAC5/7 and MEF2 in inner space of nucleus
xref_analog: IMR:0001171
xref_analog: IMR:0001173
xref_analog: PubMed:11509672
xref_analog: PubMed:11585834
xref_analog: UniProt:Q02078
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001865 ! HDAC nuclear import signaling

[Term]
id: IEV:0001704
name: Dissociation of 14-3-3 and HDAC5/7 in cytosol
xref_analog: IMR:0000456
xref_analog: IMR:0001171
xref_analog: IMR:0001173
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0001865 ! HDAC nuclear import signaling

[Term]
id: IEV:0001705
name: Nuclear import of HDAC5/7
xref_analog: IMR:0001171
xref_analog: IMR:0001173
xref_analog: PubMed:11509672
xref_analog: PubMed:11585834
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001865 ! HDAC nuclear import signaling

[Term]
id: IEV:0001706
name: Complex formation of 14-3-3:HDAC5/7:Crm1 in inner space of nucleus
xref_analog: IMR:0000456
xref_analog: IMR:0001090
xref_analog: IMR:0001171
xref_analog: IMR:0001173
xref_analog: PubMed:11509672
xref_analog: PubMed:11585834
is_a: IEV:0001711 ! Binding of transcription factor and Crm1 in inner space of nucleus
relationship: part_of IEV:0001866 ! HDAC nuclear export signaling

[Term]
id: IEV:0001707
name: AKT(PKB)-caspase signaling
is_a: IEV:0001699 ! AKT signaling
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0001709
name: AKT(PKB)-FOXO signaling
exact_synonym: "AKT(PKB)-FKHR signaling" []
exact_synonym: "AKT(PKB)-FKHRL1 signaling" []
is_a: IEV:0001699 ! AKT signaling
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0000452 ! Insulin receptor signaling pathway (through IRS mediated signaling)
relationship: part_of IEV:0003671 ! Skeletal muscle atrophy

[Term]
id: IEV:0001710
name: Phosphorylation of FOXO3 by AKT in inner space of nucleus
exact_synonym: "Phosphorylation of FKHRL1 by AKT in inner space of nucleus" []
xref_analog: IMR:0000250
xref_analog: IMR:0002806
is_a: IEV:0003659 ! Phosphorylation of FOXO by AKT in inner space of nucleus

[Term]
id: IEV:0001711
name: Binding of transcription factor and Crm1 in inner space of nucleus
xref_analog: IMR:0000368
xref_analog: IMR:0001090
xref_analog: PubMed:11509672
is_a: IEV:0001041 ! Binding in inner space of nucleus

[Term]
id: IEV:0001712
name: Binding of Stat1 and Crm1 in inner space of nucleus
xref_analog: IMR:0000375
xref_analog: IMR:0001090
xref_analog: PubMed:11509672
is_a: IEV:0001711 ! Binding of transcription factor and Crm1 in inner space of nucleus

[Term]
id: IEV:0001713
name: Binding of NFAT and Crm1 in inner space of nucleus
xref_analog: IMR:0000421
xref_analog: IMR:0001090
xref_analog: PubMed:11509672
is_a: IEV:0001711 ! Binding of transcription factor and Crm1 in inner space of nucleus

[Term]
id: IEV:0001714
name: Complex formation of 14-3-3:HDAC5:Crm1 in inner space of nucleus
xref_analog: IMR:0000456
xref_analog: IMR:0001090
xref_analog: IMR:0001171
xref_analog: PubMed:11509672
is_a: IEV:0001706 ! Complex formation of 14-3-3:HDAC5/7:Crm1 in inner space of nucleus

[Term]
id: IEV:0001715
name: Complex formation of 14-3-3:HDAC7:Crm1 in inner space of nucleus
xref_analog: IMR:0000456
xref_analog: IMR:0001090
xref_analog: IMR:0001173
xref_analog: PubMed:11585834
is_a: IEV:0001706 ! Complex formation of 14-3-3:HDAC5/7:Crm1 in inner space of nucleus

[Term]
id: IEV:0001716
name: Nuclear export of 14-3-3:HDAC5:Crm1
xref_analog: IMR:0000456
xref_analog: IMR:0001090
xref_analog: IMR:0001171
xref_analog: PubMed:11509672
is_a: IEV:0001702 ! Nuclear export of 14-3-3:HDAC5/7:Crm1

[Term]
id: IEV:0001717
name: Nuclear export of 14-3-3:HDAC7:Crm1
xref_analog: IMR:0000456
xref_analog: IMR:0001090
xref_analog: IMR:0001173
xref_analog: PubMed:11585834
is_a: IEV:0001702 ! Nuclear export of 14-3-3:HDAC5/7:Crm1

[Term]
id: IEV:0001718
name: Binding of HDAC5 and MEF2 in inner space of nucleus
xref_analog: IMR:0001171
xref_analog: PubMed:11509672
xref_analog: UniProt:Q02078
is_a: IEV:0001703 ! Binding of HDAC5/7 and MEF2 in inner space of nucleus

[Term]
id: IEV:0001719
name: Nuclear import of HDAC5:importin alpha
xref_analog: PubMed:11509672
is_obsolete: true

[Term]
id: IEV:0001720
name: Binding of HDAC7 and MEF2 in inner space of nucleus
xref_analog: IMR:0001173
xref_analog: PubMed:11585834
xref_analog: UniProt:Q02078
is_a: IEV:0001703 ! Binding of HDAC5/7 and MEF2 in inner space of nucleus

[Term]
id: IEV:0001721
name: Dissociation of 14-3-3 and HDAC5 in cytosol
xref_analog: IMR:0000456
xref_analog: IMR:0001171
xref_analog: PubMed:11509672
is_a: IEV:0001704 ! Dissociation of 14-3-3 and HDAC5/7 in cytosol

[Term]
id: IEV:0001722
name: Dissociation of 14-3-3 and HDAC7 in cytosol
xref_analog: IMR:0000456
xref_analog: IMR:0001173
xref_analog: PubMed:11585834
is_a: IEV:0001704 ! Dissociation of 14-3-3 and HDAC5/7 in cytosol

[Term]
id: IEV:0001723
name: Dephosphorylation of HDAC7 by protein phosphatase in cytosol
xref_analog: IMR:0000272
xref_analog: IMR:0001173
xref_analog: PubMed:11585834
xref_analog: PubMed:15166223
is_a: IEV:0001701 ! Dephosphorylation of HDAC5/7 by protein phosphatase in cytosol

[Term]
id: IEV:0001724
name: Dephosphorylation of HDAC5 by protein phosphatase in cytosol
xref_analog: IMR:0000272
xref_analog: IMR:0001171
xref_analog: PubMed:11509672
is_a: IEV:0001701 ! Dephosphorylation of HDAC5/7 by protein phosphatase in cytosol

[Term]
id: IEV:0001725
name: Binding of TRAF2 and MAPKKK in cytosol
xref_analog: IMR:0000229
xref_analog: IMR:0100423
xref_analog: PubMed:10485710
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0001726
name: Binding of TRAF2 and NIK in cytosol
xref_analog: IMR:0000242
xref_analog: IMR:0100423
xref_analog: PubMed:10485710
is_a: IEV:0001725 ! Binding of TRAF2 and MAPKKK in cytosol

[Term]
id: IEV:0001727
name: AKT(PKB)-IKK signaling
is_a: IEV:0001699 ! AKT signaling

[Term]
id: IEV:0001728
name: Phosphorylation of IKK alpha by AKT(PKB)
xref_analog: IMR:0000250
relationship: part_of IEV:0001727 ! AKT(PKB)-IKK signaling

[Term]
id: IEV:0001729
name: Dephosphorylation in cytosol and/or nucleus
is_a: IEV:0000011 ! Dephosphorylation

[Term]
id: IEV:0001730
name: Binding in cytosol and/or nucleus
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0001731
name: Binding of 14-3-3 and HDAC5 in inner space of nucleus
def: "CaMK-mediated nuclear export of HDAC5 appears to require binding of 14-3-3 to Ser-259 and Ser-498 in its amino terminus. Indeed, substitution of these serines with alanines blocks both 14-3-3 binding and nuclear export of HDAC5. However, association with 14-3-3 alone is not sufficient to localize HDAC5 in the cytoplasm, since NES mutants of HDAC5 associate with 14-3-3 in a CaMK-dependent manner but remain in the nucleus." [PubMed:11509672]
xref_analog: IMR:0000456
xref_analog: IMR:0001171
xref_analog: PubMed:11509672
xref_analog: PubMed:15923258
is_a: IEV:0001041 ! Binding in inner space of nucleus
is_a: IEV:0001698 ! Binding of 14-3-3 and HDAC5/7 in cytosol and/or nucleus

[Term]
id: IEV:0001732
name: Binding of 14-3-3 and HDAC7 in cytosol and/or nucleus
xref_analog: IMR:0000456
xref_analog: IMR:0001173
xref_analog: PubMed:11585834
xref_analog: PubMed:15166223
is_a: IEV:0001698 ! Binding of 14-3-3 and HDAC5/7 in cytosol and/or nucleus

[Term]
id: IEV:0001733
name: Phosphorylation of HDAC5 by CaMK in inner space of nucleus
xref_analog: IMR:0001171
xref_analog: IMR:0100543
xref_analog: PubMed:11509672
is_a: IEV:0001082 ! Phosphorylation in inner space of nucleus
is_a: IEV:0001700 ! Phosphorylation of HDAC5/7 by CaMK in cytosol and/or nucleus

[Term]
id: IEV:0001734
name: Phosphorylation of HDAC7 by CaMKI in cytosol
xref_analog: IMR:0001173
xref_analog: IMR:0100543
xref_analog: PubMed:11585834
xref_analog: PubMed:15166223
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0001700 ! Phosphorylation of HDAC5/7 by CaMK in cytosol and/or nucleus

[Term]
id: IEV:0001735
name: Phosphorylation in cytosol and/or nucleus
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0001736
name: Binding of AKT and GSK3beta in cytosol
xref_analog: IMR:0000250
xref_analog: IMR:0100737
xref_analog: PubMed:11278246
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001737
name: Gene expression of beta-TrCP
xref_analog: IMR:0100471
is_a: IEV:0000182 ! Gene expression
relationship: part_of IEV:0001813 ! Negative feedback regulation of Wnt signaling pathway (through beta-TrCP)

[Term]
id: IEV:0001738
name: Binding of APC and beta catenin in cytosol
xref_analog: IMR:0000177
xref_analog: IMR:0000205
xref_analog: PubMed:8259519
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001739 ! Beta catenin degradation signaling

[Term]
id: IEV:0001739
name: Beta catenin degradation signaling
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [GO:0031146]
exact_synonym: "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process" []
exact_synonym: "SCF-dependent proteasomal ubiquitin-dependent protein degradation" []
xref_analog: GO:0031146
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
is_a: IEV:0001676 ! Negative regulation of Wnt signaling pathway
relationship: part_of IEV:0001813 ! Negative feedback regulation of Wnt signaling pathway (through beta-TrCP)

[Term]
id: IEV:0001741
name: Proteasome degradation of beta catenin by 26S proteasome in cytosol
xref_analog: IMR:0000177
xref_analog: IMR:0000310
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0001739 ! Beta catenin degradation signaling

[Term]
id: IEV:0001742
name: Phosphorylation of beta-catenin by GSK3beta in cytosol
xref_analog: IMR:0000177
xref_analog: IMR:0100737
is_a: IEV:0001970 ! Phosphorylation of beta-catenin by GSK-3 in cytosol
relationship: part_of IEV:0001739 ! Beta catenin degradation signaling

[Term]
id: IEV:0001743
name: Phosphorylation of GSK3beta by AKT in cytosol
xref_analog: IMR:0000250
xref_analog: IMR:0100737
xref_analog: PubMed:11278246
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0001745 ! AKT(PKB)-GSK3beta signaling

[Term]
id: IEV:0001744
name: GSK3beta inactivation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling
is_a: IEV:0001677 ! Positive regulation of Wnt signaling pathway

[Term]
id: IEV:0001745
name: AKT(PKB)-GSK3beta signaling
is_a: IEV:0001699 ! AKT signaling
is_a: IEV:0001744 ! GSK3beta inactivation signaling
relationship: part_of IEV:0000452 ! Insulin receptor signaling pathway (through IRS mediated signaling)

[Term]
id: IEV:0001746
name: Regulation of EPO signaling pathway
is_a: IEV:0000550 ! Regulation of JAK STAT pathway
relationship: regulates IEV:0000867 ! EPO signaling pathway

[Term]
id: IEV:0001747
name: Negative regulation of EPO signaling pathway
is_a: IEV:0000150 ! Negative regulation of JAK STAT pathway
is_a: IEV:0001746 ! Regulation of EPO signaling pathway
relationship: negatively_regulates IEV:0000867 ! EPO signaling pathway

[Term]
id: IEV:0001748
name: Positive regulation of EPO signaling pathway
is_a: IEV:0000551 ! Positive regulation of JAK STAT pathway
is_a: IEV:0001746 ! Regulation of EPO signaling pathway
relationship: positively_regulates IEV:0000867 ! EPO signaling pathway

[Term]
id: IEV:0001749
name: Regulation of Growth hormone signaling pathway (JAK2 STAT5)
is_a: IEV:0000550 ! Regulation of JAK STAT pathway
relationship: regulates IEV:0000133 ! Growth hormone signaling pathway (JAK2, STAT5)

[Term]
id: IEV:0001750
name: Negative regulation of Growth hormone signaling pathway (JAK2 STAT5)
is_a: IEV:0000150 ! Negative regulation of JAK STAT pathway
is_a: IEV:0001749 ! Regulation of Growth hormone signaling pathway (JAK2 STAT5)
relationship: negatively_regulates IEV:0000133 ! Growth hormone signaling pathway (JAK2, STAT5)

[Term]
id: IEV:0001751
name: Positive regulation of Growth hormone signaling pathway (JAK2 STAT5)
is_a: IEV:0000551 ! Positive regulation of JAK STAT pathway
is_a: IEV:0001749 ! Regulation of Growth hormone signaling pathway (JAK2 STAT5)
relationship: positively_regulates IEV:0000133 ! Growth hormone signaling pathway (JAK2, STAT5)

[Term]
id: IEV:0001752
name: Regulation of JAK STAT signaling (Angiotensin induced)
exact_synonym: "Regulation of JAK STAT signaling pathway (Angiotensin induced)" []
is_a: IEV:0000550 ! Regulation of JAK STAT pathway
relationship: regulates IEV:0000062 ! JAK STAT signaling (Angiotensin induced)

[Term]
id: IEV:0001753
name: Negative regulation of JAK STAT signaling (Angiotensin induced)
exact_synonym: "Negative regulation of JAK STAT signaling pathway (Angiotensin induced)" []
is_a: IEV:0000150 ! Negative regulation of JAK STAT pathway
is_a: IEV:0001752 ! Regulation of JAK STAT signaling (Angiotensin induced)
relationship: negatively_regulates IEV:0000062 ! JAK STAT signaling (Angiotensin induced)

[Term]
id: IEV:0001754
name: Positive regulation of JAK STAT signaling (Angiotensin induced)
exact_synonym: "Positive regulation of JAK STAT signaling pathway (Angiotensin induced)" []
is_a: IEV:0000551 ! Positive regulation of JAK STAT pathway
is_a: IEV:0001752 ! Regulation of JAK STAT signaling (Angiotensin induced)
relationship: positively_regulates IEV:0000062 ! JAK STAT signaling (Angiotensin induced)

[Term]
id: IEV:0001755
name: Regulation of TPO signaling pathway (through JAK STAT pathway)
is_a: IEV:0000550 ! Regulation of JAK STAT pathway
relationship: regulates IEV:0001233 ! TPO signaling pathway (JAK2, STAT3)

[Term]
id: IEV:0001756
name: Negative regulation of TPO signaling pathway (through JAK STAT pathway)
is_a: IEV:0000150 ! Negative regulation of JAK STAT pathway
is_a: IEV:0001755 ! Regulation of TPO signaling pathway (through JAK STAT pathway)
relationship: negatively_regulates IEV:0001233 ! TPO signaling pathway (JAK2, STAT3)

[Term]
id: IEV:0001757
name: Positive regulation of TPO signaling pathway (through JAK STAT pathway)
is_a: IEV:0000551 ! Positive regulation of JAK STAT pathway
is_a: IEV:0001755 ! Regulation of TPO signaling pathway (through JAK STAT pathway)
relationship: positively_regulates IEV:0001233 ! TPO signaling pathway (JAK2, STAT3)

[Term]
id: IEV:0001761
name: Sumoylation of Smad3 by PIAS4 in cytosol
xref_analog: IMR:0002926
xref_analog: IMR:0100312
xref_analog: PubMed:12815042
is_a: IEV:0001055 ! SUMOylation in cytosol
relationship: part_of IEV:0001762 ! Negative feedback regulation pathway of TGF beta superfamily signaling by (Smad3 sumoylation by PIAS)

[Term]
id: IEV:0001762
name: Negative feedback regulation pathway of TGF beta superfamily signaling by (Smad3 sumoylation by PIAS)
xref_analog: IMR:0002914
xref_analog: IMR:0100312
is_a: IEV:0000885 ! Negative feedback regulation pathway of TGF beta superfamily signaling

[Term]
id: IEV:0001763
name: Gene expression of PIAS4 (induced by TGF-beta)
def: "Hep3B cells" [PubMed:12815042]
xref_analog: IMR:0002926
xref_analog: PubMed:12815042
is_a: IEV:0000182 ! Gene expression
relationship: part_of IEV:0001762 ! Negative feedback regulation pathway of TGF beta superfamily signaling by (Smad3 sumoylation by PIAS)

[Term]
id: IEV:0001765
name: Sumoylation of STAT1 by PIAS in nucleus
xref_analog: IMR:0000375
xref_analog: IMR:0002914
xref_analog: PubMed:12855578
is_a: IEV:0001825 ! Sumoylation of STAT1/3/4 by PIAS in nucleus
relationship: part_of IEV:0001767 ! Negative regulation of JAK STAT pathway by (sumoylation of STAT by PIAS1/3)

[Term]
id: IEV:0001767
name: Negative regulation of JAK STAT pathway by (sumoylation of STAT by PIAS1/3)
xref_analog: IMR:0000374
xref_analog: IMR:0002915
is_a: IEV:0000150 ! Negative regulation of JAK STAT pathway

[Term]
id: IEV:0001769
name: Binding of Androgen and Androgen receptor in inner space of nucleus
xref_analog: IMR:0100035
xref_analog: UniProt:P10275
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001770
name: Binding of Androgen receptor and responsive element in inner space of nucleus
xref_analog: IGS:0000028
xref_analog: UniProt:P10275
is_a: IEV:0002098 ! Binding of transcription factor and responsive element in inner space of nucleus
relationship: part_of IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001771
name: Nuclear import of Androgen
xref_analog: IMR:0100035
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001772
name: Transcription by Androgen receptor in nucleus
xref_analog: UniProt:P10275
is_a: IEV:0003549 ! Transcription in nucleus
relationship: part_of IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001773
name: Translocation of Androgen from extracellular to cytosol
xref_analog: IMR:0100035
is_a: IEV:0001203 ! Translocation from extracellular to cytosol
relationship: part_of IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001774
name: Binding of Androgen receptor and Hsp90 in cytosol
xref_analog: UniProt:P10275
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001775
name: Nuclear import of Androgen receptor:Hsp90
xref_analog: UniProt:P10275
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001776
name: Regulation of Steroid receptor signaling
exact_synonym: "Regulation of Steroid receptor signaling pathway" []
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0001231 ! Steroid receptor signaling pathway

[Term]
id: IEV:0001777
name: Negative regulation of Steroid receptor signaling pathway
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
is_a: IEV:0001776 ! Regulation of Steroid receptor signaling
relationship: negatively_regulates IEV:0001231 ! Steroid receptor signaling pathway

[Term]
id: IEV:0001778
name: Positive regulation of Steroid receptor signaling pathway
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
is_a: IEV:0001776 ! Regulation of Steroid receptor signaling
relationship: positively_regulates IEV:0001231 ! Steroid receptor signaling pathway

[Term]
id: IEV:0001779
name: Regulation of Estrogen receptor signaling pathway
def: "Any process that modulates the frequency, rate or extent of the activity of an estrogen receptor signaling pathway." [GO:0033146]
xref_analog: GO:0033146
is_a: IEV:0001776 ! Regulation of Steroid receptor signaling
relationship: regulates IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001780
name: Regulation of Androgen receptor signaling pathway
is_a: IEV:0001776 ! Regulation of Steroid receptor signaling
relationship: regulates IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001781
name: Negative regulation of Androgen receptor signaling pathway
is_a: IEV:0001777 ! Negative regulation of Steroid receptor signaling pathway
is_a: IEV:0001780 ! Regulation of Androgen receptor signaling pathway
relationship: negatively_regulates IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001782
name: Positive regulation of Androgen receptor signaling pathway
is_a: IEV:0001778 ! Positive regulation of Steroid receptor signaling pathway
is_a: IEV:0001780 ! Regulation of Androgen receptor signaling pathway
relationship: positively_regulates IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001783
name: Negative regulation of Estrogen receptor signaling pathway
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an estrogen receptor signaling pathway." [GO:0033147]
xref_analog: GO:0033147
is_a: IEV:0001777 ! Negative regulation of Steroid receptor signaling pathway
is_a: IEV:0001779 ! Regulation of Estrogen receptor signaling pathway
relationship: negatively_regulates IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001784
name: Positive regulation of Estrogen receptor signaling pathway
def: "Any process that activates or increases the frequency, rate or extent of the activity of an estrogen receptor signaling pathway." [GO:0033148]
xref_analog: GO:0033148
is_a: IEV:0001778 ! Positive regulation of Steroid receptor signaling pathway
is_a: IEV:0001779 ! Regulation of Estrogen receptor signaling pathway
relationship: positively_regulates IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001785
name: Binding of Androgen receptor and PIAS4 in cytosol and/or nucleus
xref_analog: IMR:0002926
xref_analog: PubMed:14981544
xref_analog: UniProt:P10275
is_a: IEV:0001730 ! Binding in cytosol and/or nucleus
relationship: part_of IEV:0001786 ! Negative regulation of Androgen receptor signaling pathway by PIAS-mediated repression of Androgen receptor

[Term]
id: IEV:0001786
name: Negative regulation of Androgen receptor signaling pathway by PIAS-mediated repression of Androgen receptor
is_a: IEV:0001781 ! Negative regulation of Androgen receptor signaling pathway

[Term]
id: IEV:0001787
name: Sumoylation of Androgen receptor by PIAS4
xref_analog: IMR:0002926
xref_analog: PubMed:14981544
xref_analog: UniProt:P10275
is_a: IEV:0001054 ! SUMOylation in unidentified cellular location
relationship: part_of IEV:0001786 ! Negative regulation of Androgen receptor signaling pathway by PIAS-mediated repression of Androgen receptor

[Term]
id: IEV:0001788
name: Binding of Androgen receptor and HDAC in inner space of nucleus
xref_analog: IMR:0001166
xref_analog: PubMed:14981544
xref_analog: UniProt:P10275
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001786 ! Negative regulation of Androgen receptor signaling pathway by PIAS-mediated repression of Androgen receptor

[Term]
id: IEV:0001789
name: Homodimerization of Androgen receptor in inner space of nucleus
xref_analog: UniProt:P10275
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001790
name: Homodimerization of Estrogen receptor in inner space of nucleus
xref_analog: IMR:0000088
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001791
name: Regulation of calcineurin activation signaling
is_a: IEV:0001796 ! Regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0001303 ! Calcineurin activation signaling

[Term]
id: IEV:0001792
name: Negative regulation of calcineurin activation signaling
is_a: IEV:0001791 ! Regulation of calcineurin activation signaling
is_a: IEV:0001797 ! Negative regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: negatively_regulates IEV:0001303 ! Calcineurin activation signaling

[Term]
id: IEV:0001793
name: Positive regulation of calcineurin activation signaling
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
is_a: IEV:0001791 ! Regulation of calcineurin activation signaling
is_a: IEV:0001798 ! Positive regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: positively_regulates IEV:0001303 ! Calcineurin activation signaling

[Term]
id: IEV:0001794
name: Binding of calcineurin and FK506
xref_analog: IMR:0000278
xref_analog: KEGG:C01375
is_a: IEV:0000186 ! Binding in unidentified cellular location
relationship: part_of IEV:0001792 ! Negative regulation of calcineurin activation signaling

[Term]
id: IEV:0001795
name: Binding of calcineurin and CSK
xref_analog: IMR:0000212
xref_analog: IMR:0000278
is_a: IEV:0000186 ! Binding in unidentified cellular location
relationship: part_of IEV:0001792 ! Negative regulation of calcineurin activation signaling

[Term]
id: IEV:0001796
name: Regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
exact_synonym: "Regulation of CD4 T cell receptor signaling pathway (through PLC gamma, calcineurin and NF-AT)" []
is_a: IEV:0001374 ! Regulation of T cell receptor signaling pathway

[Term]
id: IEV:0001797
name: Negative regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
exact_synonym: "Negative regulation of CD4 T cell receptor signaling  pathway (through PLC gamma, calcineurin and NF-AT)" []
is_a: IEV:0001375 ! Negative regulation of T cell receptor signaling pathway
is_a: IEV:0001796 ! Regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0001798
name: Positive regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
exact_synonym: "Positive regulation of CD4 T cell receptor signaling pathway (through PLC gamma, calcineurin and NF-AT)" []
xref_analog: IMR:0000421
is_a: IEV:0001376 ! Positive regulation of T cell receptor signaling pathway
is_a: IEV:0001796 ! Regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0001799
name: Regulation of Bad activation signaling
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000406 ! Bad activation signaling

[Term]
id: IEV:0001800
name: Negative regulation of Bad activation signaling
is_a: IEV:0001799 ! Regulation of Bad activation signaling
relationship: negatively_regulates IEV:0000406 ! Bad activation signaling

[Term]
id: IEV:0001801
name: Positive regulation of Bad activation signaling
is_a: IEV:0001799 ! Regulation of Bad activation signaling
relationship: positively_regulates IEV:0000406 ! Bad activation signaling

[Term]
id: IEV:0001802
name: Binding of AKT and Hsp90 in cytosol
xref_analog: IMR:0000250
xref_analog: PubMed:10995457
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001861 ! Negative regulation of (dephosphorylation of AKT(PKB) in negative regulation of AKT(PKB) activation signaling)
relationship: part_of IEV:0001862 ! Positive regulation of (phosphorylation of AKT(PKB) in AKT(PKB) activation signaling

[Term]
id: IEV:0001803
name: Dephosphorylation of AKT(PKB) by PP2A
xref_analog: IMR:0000250
xref_analog: IMR:0000280
xref_analog: PubMed:10995457
relationship: part_of IEV:0001848 ! Negative regulation of (phosphorylation of AKT(PKB)) in AKT(PKB) activation signaling

[Term]
id: IEV:0001805
name: Binding of Naked and DSH in cytosol
xref_analog: IMR:0100755
xref_analog: UniProt:Q969F2
xref_analog: UniProt:Q969G9
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001806
name: Binding of Idax and DSH in cytosol
xref_analog: IMR:0100755
xref_analog: UniProt:Q9H2H0
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001807
name: TCF phosphorylation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling
is_a: IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001808
name: Binding of TAB1 and TAK1 in cytosol
xref_analog: IMR:0000232
xref_analog: IMR:0000441
xref_analog: PubMed:14687659
xref_analog: PubMed:15733830
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001807 ! TCF phosphorylation signaling
relationship: part_of IEV:0002339 ! TGF beta signaling pathway (through TAK1)

[Term]
id: IEV:0001809
name: Phosphorylation of NLK by TAK1 in cytosol
xref_analog: IMR:0000232
xref_analog: IMR:0001164
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001807 ! TCF phosphorylation signaling

[Term]
id: IEV:0001810
name: Phosphorylation of TCF by NLK in cytosol
xref_analog: IMR:0000418
xref_analog: IMR:0001164
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001807 ! TCF phosphorylation signaling

[Term]
id: IEV:0001811
name: Negative feedback regulation of Wnt signaling pathway
is_a: IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001812
name: Binding of beta catenin and beta-TrCP in cytosol
xref_analog: IMR:0000177
xref_analog: IMR:0100471
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001813 ! Negative feedback regulation of Wnt signaling pathway (through beta-TrCP)

[Term]
id: IEV:0001813
name: Negative feedback regulation of Wnt signaling pathway (through beta-TrCP)
is_a: IEV:0001811 ! Negative feedback regulation of Wnt signaling pathway

[Term]
id: IEV:0001814
name: Binding of SFRP and Wnt receptor in extracellular
xref_analog: IMR:0000983
xref_analog: PubMed:15549094
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001815
name: Binding of Wnt and LRP5/6 in extracellular
xref_analog: IMR:0000003
xref_analog: IMR:0002954
xref_analog: PubMed:15549094
is_a: IEV:0001816 ! Binding of Wnt and Wnt receptor in extracellular

[Term]
id: IEV:0001816
name: Binding of Wnt and Wnt receptor in extracellular
xref_analog: IMR:0000003
xref_analog: PubMed:15549094
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001817
name: Binding of WIF and Wnt receptor in extracellular
xref_analog: IMR:0000989
xref_analog: PubMed:15549094
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001818
name: Binding of Dkk and Wnt receptor in extracellular
xref_analog: IMR:0000991
xref_analog: PubMed:15549094
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001819
name: Complex formation of beta catenin, TCF/LEF, Legless, Pygopus, etc. in inner space of nucleus
xref_analog: IMR:0000177
xref_analog: IMR:0000418
xref_analog: IMR:0001178
xref_analog: IMR:0001179
xref_analog: PubMed:15549094
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001820
name: Blood circulation
def: "The flow of blood through the body of an animal, enabling the transport of O2 and nutrients to the tissues and the removal of waste products." [GO:0008015]
xref_analog: GO:0008015
is_a: IEV:0003658 ! Circulatory system process

[Term]
id: IEV:0001821
name: Regulation of blood vessel size
def: "Any process that modulates the size of blood vessels." [GO:0050880]
xref_analog: GO:0050880
relationship: part_of IEV:0001820 ! Blood circulation

[Term]
id: IEV:0001822
name: Vasoconstriction
def: "A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure." [GO:0042310]
exact_synonym: "Negative regulation of blood vessel size" [GO:0042310]
xref_analog: GO:0042310
is_a: IEV:0001821 ! Regulation of blood vessel size

[Term]
id: IEV:0001823
name: Muscle cell differentiation
def: "The process whereby a relatively unspecialized cell acquires specialized features of a muscle cell." [GO:0042692]
xref_analog: GO:0042692
is_a: IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0001824
name: Smooth muscle cell differentiation
def: "The process whereby a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [GO:0051145]
exact_synonym: "nonstriated muscle cell differentiation" [GO:0051145]
xref_analog: GO:0051145
is_a: IEV:0001823 ! Muscle cell differentiation

[Term]
id: IEV:0001825
name: Sumoylation of STAT1/3/4 by PIAS in nucleus
xref_analog: IMR:0000375
xref_analog: IMR:0000377
xref_analog: IMR:0000378
xref_analog: IMR:0002914
xref_analog: PubMed:14607831
is_a: IEV:0001831 ! Sumoylation of trans-activator by PIAS in nucleus
relationship: part_of IEV:0003695 ! Negative regulation of transcription in JAK STAT pathway

[Term]
id: IEV:0001826
name: Sumoylation of STAT1/3/4 by PIAS1/3 in nucleus
xref_analog: IMR:0000375
xref_analog: IMR:0000377
xref_analog: IMR:0000378
xref_analog: IMR:0002915
xref_analog: IMR:0002922
xref_analog: PubMed:14607831
is_a: IEV:0001825 ! Sumoylation of STAT1/3/4 by PIAS in nucleus

[Term]
id: IEV:0001827
name: Sumoylation of STAT1/3/4 by PIAS2/4 in nucleus
xref_analog: IMR:0000375
xref_analog: IMR:0000377
xref_analog: IMR:0000378
xref_analog: IMR:0002918
xref_analog: IMR:0002926
xref_analog: PubMed:14607831
is_a: IEV:0001825 ! Sumoylation of STAT1/3/4 by PIAS in nucleus

[Term]
id: IEV:0001828
name: SUMOylation in cytosol and/or nucleus
is_a: IEV:0000118 ! SUMOylation

[Term]
id: IEV:0001829
name: SUMOylation in nucleus
is_a: IEV:0001828 ! SUMOylation in cytosol and/or nucleus

[Term]
id: IEV:0001831
name: Sumoylation of trans-activator by PIAS in nucleus
xref_analog: IMR:0002914
xref_analog: PubMed:15021887
is_a: IEV:0001829 ! SUMOylation in nucleus
relationship: part_of IEV:0000148 ! Negative regulation of transcription by PIAS

[Term]
id: IEV:0001832
name: Binding of trans-activator and co-repressor in inner space of nucleus
xref_analog: PubMed:15021887
is_a: IEV:0001041 ! Binding in inner space of nucleus

[Term]
id: IEV:0001833
name: Regulation of transcription
def: "Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GO:0045449]
xref_analog: GO:0045449
is_a: IEV:0001835 ! Regulation of gene expression
relationship: regulates IEV:0000183 ! Transcription

[Term]
id: IEV:0001834
name: Positive regulation of transcription
def: "Any process that activates or increases the frequency, rate or extent of transcription." [GO:0045941]
exact_synonym: "up regulation of transcription" []
xref_analog: GO:0045941
is_a: IEV:0001833 ! Regulation of transcription
relationship: part_of IEV:0001836 ! Positive regulation of gene expression
relationship: positively_regulates IEV:0000183 ! Transcription

[Term]
id: IEV:0001835
name: Regulation of gene expression
def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GO:0010468]
xref_analog: GO:0010468
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000182 ! Gene expression

[Term]
id: IEV:0001836
name: Positive regulation of gene expression
def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GO:0010628]
xref_analog: GO:0010628
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
is_a: IEV:0001835 ! Regulation of gene expression
relationship: positively_regulates IEV:0000182 ! Gene expression

[Term]
id: IEV:0001837
name: Negative regulation of gene expression
def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GO:0010629]
xref_analog: GO:0010629
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
is_a: IEV:0001835 ! Regulation of gene expression
relationship: negatively_regulates IEV:0000182 ! Gene expression

[Term]
id: IEV:0001838
name: Negative regulation of transcription
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription." [GO:0016481]
exact_synonym: "down regulation of transcription" []
xref_analog: GO:0016481
is_a: IEV:0001833 ! Regulation of transcription
relationship: negatively_regulates IEV:0000183 ! Transcription
relationship: part_of IEV:0001837 ! Negative regulation of gene expression

[Term]
id: IEV:0001839
name: Negative regulation of translation
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GO:0017148]
exact_synonym: "down regulation of protein biosynthetic process" []
exact_synonym: "negative regulation of protein anabolism" []
exact_synonym: "negative regulation of protein biosynthesis" []
exact_synonym: "negative regulation of protein biosynthetic process" []
exact_synonym: "negative regulation of protein formation" []
exact_synonym: "negative regulation of protein synthesis" []
xref_analog: GO:0017148
is_a: IEV:0001841 ! Regulation of translation
relationship: negatively_regulates IEV:0000219 ! Translation
relationship: part_of IEV:0001837 ! Negative regulation of gene expression

[Term]
id: IEV:0001840
name: Positive regulation of translation
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GO:0045727]
exact_synonym: "positive regulation of protein anabolism" []
exact_synonym: "positive regulation of protein biosynthesis" []
exact_synonym: "positive regulation of protein biosynthetic process" []
exact_synonym: "positive regulation of protein formation" []
exact_synonym: "positive regulation of protein synthesis" []
exact_synonym: "up regulation of protein biosynthetic process" []
xref_analog: GO:0045727
is_a: IEV:0001841 ! Regulation of translation
relationship: part_of IEV:0001836 ! Positive regulation of gene expression
relationship: positively_regulates IEV:0000219 ! Translation

[Term]
id: IEV:0001841
name: Regulation of translation
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GO:0006417]
exact_synonym: "regulation of protein anabolism" []
exact_synonym: "regulation of protein biosynthesis" []
exact_synonym: "regulation of protein formation" []
exact_synonym: "regulation of protein synthesis" []
xref_analog: GO:0006417
is_a: IEV:0001835 ! Regulation of gene expression
relationship: regulates IEV:0000219 ! Translation

[Term]
id: IEV:0001842
name: Signaling pathway
def: "The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms." [GO:0023033]
xref_analog: GO:0023033
is_a: IEV:0000001 ! Pathway

[Term]
id: IEV:0001843
name: Negative regulation of (Phosphorylation of cytokine receptor) in JAK STAT pathway
xref_analog: IMR:0000095
is_a: IEV:0000150 ! Negative regulation of JAK STAT pathway

[Term]
id: IEV:0001844
name: Negative regulation of (Phosphorylation of JAK) in JAK STAT pathway
xref_analog: IMR:0000213
xref_analog: PubMed:14607831
is_a: IEV:0000150 ! Negative regulation of JAK STAT pathway

[Term]
id: IEV:0001845
name: Negative regulation of (Phosphorylation of STAT) in JAK STAT pathway
xref_analog: IMR:0000374
is_a: IEV:0000150 ! Negative regulation of JAK STAT pathway

[Term]
id: IEV:0001846
name: Negative regulation of (nuclear import of R-Smad:Smad4) in TGF beta super family signaling pathway
xref_analog: IMR:0000371
xref_analog: IMR:0100315
is_a: IEV:0000880 ! Negative regulation of TGF beta super family signaling pathway

[Term]
id: IEV:0001847
name: Positive regulation of (transcription by R-Smad:Smad4 ) in TGF beta super family signaling pathway by (Smad4 sumoylation by PIAS1)
xref_analog: IMR:0000371
xref_analog: IMR:0100315
is_a: IEV:0002190 ! Positive regulation of (transcription by R-Smad:Smad4 ) in TGF beta super family signaling pathway

[Term]
id: IEV:0001848
name: Negative regulation of (phosphorylation of AKT(PKB)) in AKT(PKB) activation signaling
is_a: IEV:0001486 ! Negative regulation of AKT(PKB) activation signaling

[Term]
id: IEV:0001849
name: Negative regulation of (dephosphorylation of AKT(PKB)) in negative regulation of AKT(PKB)-Bad signaling
is_obsolete: true

[Term]
id: IEV:0001850
name: Regulation of AKT(PKB)-Bad signaling
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000166 ! AKT(PKB)-Bad signaling

[Term]
id: IEV:0001851
name: Negative regulation of AKT(PKB)-Bad signaling
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
is_a: IEV:0001850 ! Regulation of AKT(PKB)-Bad signaling
relationship: negatively_regulates IEV:0000166 ! AKT(PKB)-Bad signaling

[Term]
id: IEV:0001852
name: Positive regulation of AKT(PKB)-Bad signaling
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
is_a: IEV:0001850 ! Regulation of AKT(PKB)-Bad signaling
relationship: positively_regulates IEV:0000166 ! AKT(PKB)-Bad signaling

[Term]
id: IEV:0001853
name: Positive regulation of (phosphorylation of Bad) in AKT(PKB)-Bad signaling
is_obsolete: true

[Term]
id: IEV:0001854
name: Binding of TGF beta and TGF-beta receptor II in extracellular
xref_analog: IMR:0000041
xref_analog: IMR:0000712
is_a: IEV:0003594 ! Binding of TGF beta superfamily and TGF beta superfamily receptor II in extracellular
relationship: part_of IEV:0002339 ! TGF beta signaling pathway (through TAK1)

[Term]
id: IEV:0001855
name: Binding of TGF beta:TGF beta receptor II and TGF beta receptor I in plasma membrane
xref_analog: IMR:0000041
xref_analog: IMR:0000710
xref_analog: IMR:0000712
is_a: IEV:0003593 ! Binding of TGF beta super family:Type II receptor and Type I receptor in plasma membrane
relationship: part_of IEV:0002339 ! TGF beta signaling pathway (through TAK1)

[Term]
id: IEV:0001856
name: Binding of BMP2 and BMP receptor I in extracellular
xref_analog: IMR:0001424
xref_analog: IMR:0001425
is_a: IEV:0002172 ! Binding of BMP2 and BMP receptor I/II in extracellular
relationship: part_of IEV:0002338 ! BMP2 signaling pathway(through TAK1)

[Term]
id: IEV:0001857
name: Negative regulation of (phosphorylation of Bad) in AKT(PKB)-Bad signaling
is_obsolete: true

[Term]
id: IEV:0001858
name: Negative regulation of (phosphorylation of PIP2) in AKT(PKB) activation signaling
xref_analog: IMR:0001350
is_a: IEV:0001486 ! Negative regulation of AKT(PKB) activation signaling

[Term]
id: IEV:0001859
name: Regulation of (negative regulation of AKT(PKB) activation signaling)
is_a: IEV:0001486 ! Negative regulation of AKT(PKB) activation signaling

[Term]
id: IEV:0001860
name: Negative regulation of (negative regulation of AKT(PKB) activation signaling)
is_a: IEV:0001859 ! Regulation of (negative regulation of AKT(PKB) activation signaling)

[Term]
id: IEV:0001861
name: Negative regulation of (dephosphorylation of AKT(PKB) in negative regulation of AKT(PKB) activation signaling)
is_a: IEV:0001860 ! Negative regulation of (negative regulation of AKT(PKB) activation signaling)

[Term]
id: IEV:0001862
name: Positive regulation of (phosphorylation of AKT(PKB) in AKT(PKB) activation signaling
is_a: IEV:0001487 ! Positive regulation of AKT(PKB) activation signaling

[Term]
id: IEV:0001863
name: Protein nuclear import/export signaling
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0001864
name: HDAC nuclear import/export signaling
is_a: IEV:0001863 ! Protein nuclear import/export signaling

[Term]
id: IEV:0001865
name: HDAC nuclear import signaling
is_a: IEV:0001875 ! Negative regulation of transcription in endothelin signaling by histone acetylation
relationship: part_of IEV:0001864 ! HDAC nuclear import/export signaling

[Term]
id: IEV:0001866
name: HDAC nuclear export signaling
relationship: part_of IEV:0001693 ! Endothelin receptor signaling
relationship: part_of IEV:0001864 ! HDAC nuclear import/export signaling

[Term]
id: IEV:0001867
name: Regulation of HDAC nuclear export signaling
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0001866 ! HDAC nuclear export signaling

[Term]
id: IEV:0001868
name: Positive regulation of HDAC nuclear export signaling
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
is_a: IEV:0001867 ! Regulation of HDAC nuclear export signaling
relationship: positively_regulates IEV:0001866 ! HDAC nuclear export signaling

[Term]
id: IEV:0001869
name: Negative regulation of HDAC nuclear export signaling
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
is_a: IEV:0001867 ! Regulation of HDAC nuclear export signaling
relationship: negatively_regulates IEV:0001866 ! HDAC nuclear export signaling

[Term]
id: IEV:0001870
name: Regulation of HDAC nuclear import signaling
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0001865 ! HDAC nuclear import signaling

[Term]
id: IEV:0001871
name: Negative regulation of HDAC nuclear import signaling
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
is_a: IEV:0001870 ! Regulation of HDAC nuclear import signaling
relationship: negatively_regulates IEV:0001865 ! HDAC nuclear import signaling

[Term]
id: IEV:0001872
name: Positive regulation of HDAC nuclear import signaling
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
is_a: IEV:0001870 ! Regulation of HDAC nuclear import signaling
relationship: positively_regulates IEV:0001865 ! HDAC nuclear import signaling

[Term]
id: IEV:0001873
name: Dissociation of HDAC5/7 and MEF2 in inner space of nucleus
xref_analog: IMR:0001171
xref_analog: IMR:0001173
xref_analog: UniProt:Q02078
is_a: IEV:0001046 ! Dissociation in inner space of nucleus
relationship: part_of IEV:0001866 ! HDAC nuclear export signaling

[Term]
id: IEV:0001874
name: Transcription by MEF2 in nucleus
xref_analog: UniProt:Q02078
is_a: IEV:0003549 ! Transcription in nucleus
relationship: part_of IEV:0001693 ! Endothelin receptor signaling

[Term]
id: IEV:0001875
name: Negative regulation of transcription in endothelin signaling by histone acetylation
is_a: IEV:0001696 ! Negative regulation of endothelin receptor signaling

[Term]
id: IEV:0001876
name: Deacetylation of histone by HDAC5/7 in nucleus
xref_analog: IMR:0001171
xref_analog: IMR:0001173
xref_analog: PubMed:11509672
xref_analog: PubMed:11585834
is_a: IEV:0001683 ! Deacetylation in nucleus
relationship: part_of IEV:0001865 ! HDAC nuclear import signaling

[Term]
id: IEV:0001877
name: Binding of HDAC5 and importin alpha in cytosol
xref_analog: IMR:0001171
xref_analog: IMR:0100202
xref_analog: PubMed:11509672
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001865 ! HDAC nuclear import signaling

[Term]
id: IEV:0001878
name: Heparan sulfate biosynthesis
xref_analog: KEGG:map00534
is_a: IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001879
name: Deacetylation of histone by HDAC5 in nucleus
xref_analog: IMR:0001171
xref_analog: PubMed:11509672
is_a: IEV:0001876 ! Deacetylation of histone by HDAC5/7 in nucleus

[Term]
id: IEV:0001880
name: Deacetylation of histone by HDAC7 in nucleus
xref_analog: IMR:0001173
xref_analog: PubMed:11585834
is_a: IEV:0001876 ! Deacetylation of histone by HDAC5/7 in nucleus

[Term]
id: IEV:0001881
name: Tryptophan biosynthesis
def: "The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [GO:0000162]
exact_synonym: "tryptophan anabolism" []
exact_synonym: "tryptophan biosynthetic process" []
exact_synonym: "tryptophan formation" []
exact_synonym: "tryptophan synthesis" []
xref_analog: GO:0000162
xref_analog: KEGG:map00400
is_a: IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0001882
name: Nuclear import of HDAC5
xref_analog: IMR:0001171
xref_analog: PubMed:11509672
is_a: IEV:0001705 ! Nuclear import of HDAC5/7

[Term]
id: IEV:0001883
name: Nuclear import of HDAC7
xref_analog: IMR:0001173
xref_analog: PubMed:11585834
is_a: IEV:0001705 ! Nuclear import of HDAC5/7

[Term]
id: IEV:0001884
name: Dissociation of HDAC7 and MEF2 in inner space of nucleus
xref_analog: IMR:0001173
xref_analog: UniProt:Q02078
is_a: IEV:0001873 ! Dissociation of HDAC5/7 and MEF2 in inner space of nucleus

[Term]
id: IEV:0001885
name: Dissociation of HDAC5 and MEF2 in inner space of nucleus
xref_analog: IMR:0001171
xref_analog: UniProt:Q02078
is_a: IEV:0001873 ! Dissociation of HDAC5/7 and MEF2 in inner space of nucleus

[Term]
id: IEV:0001886
name: Molecular interaction
alt_id: IEV:0000220
alt_id: IEV:0000922
narrow_synonym: "Unknown interaction" []
narrow_synonym: "Unknown process" []
is_a: IEV:0000071 ! Molecular event

[Term]
id: IEV:0001887
name: Phosphorylation of Fyn by Csk and inactive conformational change in cytosol
xref_analog: IMR:0000212
xref_analog: IMR:0100352
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0001596 ! Phosphorylation of Fyn by non-receptor kinase and inactive conformational change in cytosol
is_a: IEV:0001597 ! Phosphorylation of Src family by Csk and inactive conformational change in cytosol

[Term]
id: IEV:0001888
name: Negative regulation of (Autophosphorylation of Fyn) in Fyn activation signaling
xref_analog: IMR:0100352
is_a: IEV:0001629 ! Negative regulation of Fyn activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001889
name: Negative regulation of (dephosphorylation of Fyn) in Fyn activation signaling
xref_analog: IMR:0100352
is_a: IEV:0001629 ! Negative regulation of Fyn activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001890
name: Lck inactivation signaling (through Csk)
is_a: IEV:0001632 ! Negative regulation of (dephosphorylation of Lck) Lck activation signaling (autophosphorylation and PTP)

[Term]
id: IEV:0001891
name: Fyn inactivation signaling (through Csk)
is_a: IEV:0001634 ! Fyn inactivation signaling
is_a: IEV:0001889 ! Negative regulation of (dephosphorylation of Fyn) in Fyn activation signaling

[Term]
id: IEV:0001892
name: Src inactivation signaling (through PTP)
xref_analog: IMR:0000273
is_a: IEV:0001642 ! Src inactivation signaling

[Term]
id: IEV:0001893
name: Src inactivation signaling (through non-receptor kinase)
is_a: IEV:0001642 ! Src inactivation signaling

[Term]
id: IEV:0001894
name: Negative regulation of (phosphorylation of Lck) Lck activation signaling (autophosphorylation and PTP)
xref_analog: IMR:0000273
is_a: IEV:0001896 ! Negative regulation of Lck activation signaling (autophosphorylation and PTP)

[Term]
id: IEV:0001895
name: Phosphorylation of Lck by Csk and inactive conformational change in cytosol
xref_analog: IMR:0000212
xref_analog: IMR:0100353
is_a: IEV:0001591 ! Phosphorylation of Lck by non-receptor kinase and inactive conformational change in cytosol
is_a: IEV:0001597 ! Phosphorylation of Src family by Csk and inactive conformational change in cytosol

[Term]
id: IEV:0001896
name: Negative regulation of Lck activation signaling (autophosphorylation and PTP)
xref_analog: IMR:0000273
is_a: IEV:0001631 ! Regulation of Lck activation signaling (autophosphorylation and PTP)
relationship: negatively_regulates IEV:0000519 ! Lck activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001897
name: Binding of phosphatidylserine and PKC and active conformational change of PKC in plasma membrane
xref_analog: IMR:0000245
xref_analog: IMR:0001358
xref_analog: PubMed:7499357
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000779 ! PKC activation signaling

[Term]
id: IEV:0001898
name: Binding of phosphatidylserine and cPKC and active conformational change of cPKC in plasma membrane
xref_analog: IMR:0001358
xref_analog: IMR:0100486
xref_analog: PubMed:7499357
is_a: IEV:0001897 ! Binding of phosphatidylserine and PKC and active conformational change of PKC in plasma membrane
relationship: part_of IEV:0001392 ! cPKC activation signaling

[Term]
id: IEV:0001899
name: Binding of phosphatidylserine and PKC theta and active conformational change of PKC theta in plasma membrane
xref_analog: IMR:0001358
xref_analog: IMR:0100484
xref_analog: PubMed:7499357
is_a: IEV:0001897 ! Binding of phosphatidylserine and PKC and active conformational change of PKC in plasma membrane
relationship: part_of IEV:0001391 ! PKC theta activation signaling

[Term]
id: IEV:0001900
name: Regulation of cPKC activation signaling
is_a: IEV:0001909 ! Regulation of PKC activation signaling
relationship: regulates IEV:0001392 ! cPKC activation signaling

[Term]
id: IEV:0001901
name: Negative regulation of cPKC activation signaling
is_a: IEV:0001900 ! Regulation of cPKC activation signaling
is_a: IEV:0001911 ! Negative regulation of PKC activation signaling
relationship: negatively_regulates IEV:0001392 ! cPKC activation signaling

[Term]
id: IEV:0001902
name: Positive regulation of cPKC activation signaling
is_a: IEV:0001900 ! Regulation of cPKC activation signaling
is_a: IEV:0001910 ! Positive regulation of PKC activation signaling
relationship: positively_regulates IEV:0001392 ! cPKC activation signaling

[Term]
id: IEV:0001903
name: Negative regulation of (binding of calcium ion and cPKC) in cPKC activation signaling
xref_analog: IMR:0100031
is_a: IEV:0001901 ! Negative regulation of cPKC activation signaling

[Term]
id: IEV:0001904
name: Negative regulation of (binding of DAG and cPKC) in cPKC activation signaling
is_a: IEV:0001901 ! Negative regulation of cPKC activation signaling

[Term]
id: IEV:0001905
name: Negative regulation of (binding of phosphatidylserine and cPKC) in cPKC activation signaling
xref_analog: IMR:0001358
is_a: IEV:0001901 ! Negative regulation of cPKC activation signaling

[Term]
id: IEV:0001906
name: Dissociation of calcium ion and cPKC
xref_analog: IMR:0100031
xref_analog: IMR:0100486
relationship: part_of IEV:0001903 ! Negative regulation of (binding of calcium ion and cPKC) in cPKC activation signaling

[Term]
id: IEV:0001907
name: Dissociation of DAG and cPKC
xref_analog: IMR:0100027
xref_analog: IMR:0100486
relationship: part_of IEV:0001904 ! Negative regulation of (binding of DAG and cPKC) in cPKC activation signaling

[Term]
id: IEV:0001908
name: Dissociation of phosphatidylserine and cPKC in plasma membrane
xref_analog: IMR:0001358
xref_analog: IMR:0100486
xref_analog: PubMed:7499357
is_a: IEV:0001924 ! Dissociation of phosphatidylserine and PKC in plasma membrane
relationship: part_of IEV:0001905 ! Negative regulation of (binding of phosphatidylserine and cPKC) in cPKC activation signaling

[Term]
id: IEV:0001909
name: Regulation of PKC activation signaling
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000779 ! PKC activation signaling

[Term]
id: IEV:0001910
name: Positive regulation of PKC activation signaling
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
is_a: IEV:0001909 ! Regulation of PKC activation signaling
relationship: positively_regulates IEV:0000779 ! PKC activation signaling

[Term]
id: IEV:0001911
name: Negative regulation of PKC activation signaling
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
is_a: IEV:0001909 ! Regulation of PKC activation signaling
relationship: negatively_regulates IEV:0000779 ! PKC activation signaling

[Term]
id: IEV:0001912
name: Regulation of PKC theta activation signaling
is_a: IEV:0001909 ! Regulation of PKC activation signaling
relationship: regulates IEV:0001391 ! PKC theta activation signaling

[Term]
id: IEV:0001913
name: Negative regulation of PKC theta activation signaling
is_a: IEV:0001911 ! Negative regulation of PKC activation signaling
is_a: IEV:0001912 ! Regulation of PKC theta activation signaling
relationship: negatively_regulates IEV:0001391 ! PKC theta activation signaling

[Term]
id: IEV:0001914
name: Positive regulation of PKC theta activation signaling
is_a: IEV:0001910 ! Positive regulation of PKC activation signaling
is_a: IEV:0001912 ! Regulation of PKC theta activation signaling
relationship: positively_regulates IEV:0001391 ! PKC theta activation signaling

[Term]
id: IEV:0001915
name: Negative regulation of (binding of DAG and PKC theta) in PKC theta activation signaling
is_a: IEV:0001913 ! Negative regulation of PKC theta activation signaling

[Term]
id: IEV:0001916
name: Negative regulation of (binding of phosphatidylserine and PKC theta) in PKC theta activation signaling
xref_analog: IMR:0001358
is_a: IEV:0001913 ! Negative regulation of PKC theta activation signaling

[Term]
id: IEV:0001917
name: Dissociation of DAG and PKC theta
xref_analog: IMR:0100027
xref_analog: IMR:0100484
relationship: part_of IEV:0001915 ! Negative regulation of (binding of DAG and PKC theta) in PKC theta activation signaling

[Term]
id: IEV:0001918
name: Dissociation of phosphatidylserine and PKC theta in plasma membrane
xref_analog: IMR:0001358
xref_analog: IMR:0100484
is_a: IEV:0001924 ! Dissociation of phosphatidylserine and PKC in plasma membrane
relationship: part_of IEV:0001916 ! Negative regulation of (binding of phosphatidylserine and PKC theta) in PKC theta activation signaling

[Term]
id: IEV:0001919
name: Negative regulation of (binding of calcium ion and PKC) in PKC activation signaling
xref_analog: IMR:0100031
is_a: IEV:0001911 ! Negative regulation of PKC activation signaling

[Term]
id: IEV:0001920
name: Negative regulation of (binding of DAG and PKC) in PKC activation signaling
is_a: IEV:0001911 ! Negative regulation of PKC activation signaling

[Term]
id: IEV:0001921
name: Negative regulation of (binding of phosphatidylserine and PKC) in PKC activation signaling
xref_analog: IMR:0001358
is_a: IEV:0001911 ! Negative regulation of PKC activation signaling

[Term]
id: IEV:0001922
name: Dissociation of calcium ion and PKC
xref_analog: IMR:0000245
xref_analog: IMR:0100031
relationship: part_of IEV:0001919 ! Negative regulation of (binding of calcium ion and PKC) in PKC activation signaling

[Term]
id: IEV:0001923
name: Dissociation of DAG and PKC
xref_analog: IMR:0000245
xref_analog: IMR:0100027
relationship: part_of IEV:0001920 ! Negative regulation of (binding of DAG and PKC) in PKC activation signaling

[Term]
id: IEV:0001924
name: Dissociation of phosphatidylserine and PKC in plasma membrane
xref_analog: IMR:0000245
xref_analog: IMR:0001358
xref_analog: PubMed:7499357
is_a: IEV:0000665 ! Dissociation in plasma membrane
relationship: part_of IEV:0001921 ! Negative regulation of (binding of phosphatidylserine and PKC) in PKC activation signaling

[Term]
id: IEV:0001925
name: Regulation of PKA activation signaling
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0000780 ! PKA activation signaling

[Term]
id: IEV:0001926
name: Negative regulation of PKA activation signaling
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
is_a: IEV:0001925 ! Regulation of PKA activation signaling
relationship: negatively_regulates IEV:0000780 ! PKA activation signaling

[Term]
id: IEV:0001927
name: Positive regulation of PKA activation signaling
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
is_a: IEV:0001925 ! Regulation of PKA activation signaling
relationship: positively_regulates IEV:0000780 ! PKA activation signaling

[Term]
id: IEV:0001928
name: Negative feedback regulation of p53 degradation signaling
is_obsolete: true

[Term]
id: IEV:0001929
name: Binding of Mdm2 and p14ARF in inner space of nucleus
xref_analog: IMR:0100660
xref_analog: IMR:0701007
xref_analog: PubMed:15021897
is_a: IEV:0001934 ! Binding of Mdm2 and ARF in inner space of nucleus

[Term]
id: IEV:0001930
name: Ubiquitination of Mdm4 by Mdm2 in nucleus
xref_analog: IMR:0100660
xref_analog: UniProt:O15151
is_a: IEV:0000871 ! Ubiquitination in nucleus

[Term]
id: IEV:0001931
name: Proteasome degradation of Mdm4 in cytosol
xref_analog: UniProt:O15151
is_a: IEV:0000021 ! Proteasome degradation in cytosol

[Term]
id: IEV:0001932
name: Ubiquitination of p53 by ubiquitin ligase in nucleus
xref_analog: IMR:0000329
xref_analog: IMR:0100659
xref_analog: PubMed:15021897
is_a: IEV:0000871 ! Ubiquitination in nucleus
relationship: part_of IEV:0000868 ! p53 degradation signaling

[Term]
id: IEV:0001933
name: Binding of Mdm2 and Mdm4 in inner space of nucleus
xref_analog: IMR:0100660
xref_analog: PubMed:12860999
xref_analog: UniProt:O15151
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001124 ! Positive regulation of p53 degradation signaling

[Term]
id: IEV:0001934
name: Binding of Mdm2 and ARF in inner space of nucleus
xref_analog: IMR:0000447
xref_analog: IMR:0100660
xref_analog: PubMed:12860999
xref_analog: PubMed:15021897
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001123 ! Negative regulation of p53 degradation signaling

[Term]
id: IEV:0001935
name: Nuclear import of Mdm4
xref_analog: PubMed:12860999
xref_analog: UniProt:O15151
is_a: IEV:0000018 ! Nuclear import

[Term]
id: IEV:0001936
name: Palmitoylation of Wnt by Porcupine in ER
xref_analog: IMR:0000003
xref_analog: IMR:0000981
xref_analog: PubMed:15166250
xref_analog: PubMed:15473860
xref_analog: PubMed:8985181
is_a: IEV:0001937 ! Palmitoylation in ER
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001937
name: Palmitoylation in ER
is_a: IEV:0000918 ! Palmitoylation

[Term]
id: IEV:0001938
name: Translocation of Wnt from ER to extracellular space
xref_analog: IMR:0000003
xref_analog: PubMed:15473860
is_a: IEV:0001939 ! Translocation from ER to extracellular space
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001939
name: Translocation from ER to extracellular space
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0001940
name: Translocation of Arrow/LRP5/6 from ER to plasma membrane
xref_analog: IMR:0002951
xref_analog: PubMed:12581524
xref_analog: PubMed:15473860
is_a: IEV:0001941 ! Translocation from ER to plasma membrane
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001941
name: Translocation from ER to plasma membrane
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0001942
name: Translocation from cytosol to plasma membrane
alt_id: IEV:0002197
exact_synonym: "Translocation from cytosol to plasma membrane" []
is_a: IEV:0000009 ! Translocation
relationship: part_of IEV:0001167 ! Translocation from Golgi to plasma membrane

[Term]
id: IEV:0001943
name: Translocation from ER to cytosol
alt_id: IEV:0000275
exact_synonym: "Translocation from the ER to the cytosol" []
is_a: IEV:0000009 ! Translocation
relationship: part_of IEV:0002612 ! Translocation from ER to Golgi

[Term]
id: IEV:0001944
name: Translocation of LRP6 from ER to plasma membrane
xref_analog: IMR:0000970
is_a: IEV:0001940 ! Translocation of Arrow/LRP5/6 from ER to plasma membrane

[Term]
id: IEV:0001945
name: Translocation of Arrow/LRP5/6 from ER to cytosol
xref_analog: IMR:0002951
is_a: IEV:0001943 ! Translocation from ER to cytosol

[Term]
id: IEV:0001946
name: Translocation of Arrow/LRP5/6 from cytosol to plasma membrane
xref_analog: IMR:0002951
is_a: IEV:0001942 ! Translocation from cytosol to plasma membrane

[Term]
id: IEV:0001947
name: Translocation of LRP6 from cytosol to plasma membrane
xref_analog: IMR:0000970
is_a: IEV:0001946 ! Translocation of Arrow/LRP5/6 from cytosol to plasma membrane

[Term]
id: IEV:0001948
name: Translocation of LRP6 from ER to cytosol
xref_analog: IMR:0000970
is_a: IEV:0001945 ! Translocation of Arrow/LRP5/6 from ER to cytosol

[Term]
id: IEV:0001949
name: Binding of Wnt, Frizzled and Arrow/LRP5/6 in extracellular
xref_analog: IMR:0000003
xref_analog: IMR:0000055
xref_analog: IMR:0002951
xref_analog: PubMed:11029006
xref_analog: PubMed:11029007
xref_analog: PubMed:12205098
xref_analog: PubMed:15473860
xref_analog: PubMed:8717036
is_a: IEV:0001816 ! Binding of Wnt and Wnt receptor in extracellular

[Term]
id: IEV:0001950
name: Phosphorylation of Arrow/LRP5/6 in cytosol
xref_analog: IMR:0002951
xref_analog: PubMed:11029007
xref_analog: PubMed:14731402
xref_analog: PubMed:15473860
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001951
name: Binding of Arrow/LRP5/6 and Axin in cytosol
xref_analog: IMR:0000432
xref_analog: IMR:0002951
xref_analog: PubMed:11336703
xref_analog: PubMed:1236921
xref_analog: PubMed:14731402
xref_analog: PubMed:15473860
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001952
name: Binding of Dsh and Axin in cytosol
xref_analog: IMR:0000432
xref_analog: IMR:0100755
xref_analog: PubMed:10688669
xref_analog: PubMed:15473860
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001953
name: Binding of Dsh and GBP/Frat and GSK-3 in cytosol
xref_analog: IMR:0000257
xref_analog: IMR:0001247
xref_analog: IMR:0100755
xref_analog: PubMed:10428961
xref_analog: PubMed:10684251
xref_analog: PubMed:10882137
xref_analog: PubMed:15473860
xref_analog: PubMed:9635432
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001954
name: Complex formation of Axin, APC, GSK-3, Beta catenin and PP2A in cytosol
xref_analog: IMR:0000177
xref_analog: IMR:0000205
xref_analog: IMR:0000257
xref_analog: IMR:0000280
xref_analog: IMR:0000432
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001955
name: Dephosphorylation of beta-catenin by PP2A in cytosol
xref_analog: IMR:0000177
xref_analog: IMR:0000280
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001956
name: Binding of Pygopus, Legless and beta-catenin:TCF complex in inner space of nucleus
xref_analog: IMR:0000177
xref_analog: IMR:0000418
xref_analog: IMR:0001178
xref_analog: IMR:0001179
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0001819 ! Complex formation of beta catenin, TCF/LEF, Legless, Pygopus, etc. in inner space of nucleus

[Term]
id: IEV:0001957
name: Binding of CBP and beta-catenin in inner space of nucleus
xref_analog: IMR:0000177
xref_analog: IMR:0000426
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001958
name: Binding of Brg1 and beta-catenin:TCF complex in inner space of nucleus
xref_analog: IMR:0000177
xref_analog: IMR:0000418
xref_analog: IMR:0001951
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001959
name: Binding of Wnt and WIF in extracellular
xref_analog: IMR:0000003
xref_analog: IMR:0000989
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001960
name: Binding of Wnt and SFRP in extracellular
xref_analog: IMR:0000003
xref_analog: IMR:0000983
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001961
name: Binding of Dkk, Arrow/LRP5/6 and Kremen in extracellular
xref_analog: IMR:0000991
xref_analog: IMR:0000996
xref_analog: IMR:0002951
is_a: IEV:0001818 ! Binding of Dkk and Wnt receptor in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001962
name: Binding of Dkk1, LRP6 and Kremen2 in extracellular
xref_analog: IMR:0000970
xref_analog: IMR:0000992
xref_analog: IMR:0000998
is_a: IEV:0001961 ! Binding of Dkk, Arrow/LRP5/6 and Kremen in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001963
name: Binding of Dkk2, Arrow/LRP5/6 and Kremen2 in extracellular
xref_analog: IMR:0000993
xref_analog: IMR:0000998
xref_analog: IMR:0002951
is_a: IEV:0001961 ! Binding of Dkk, Arrow/LRP5/6 and Kremen in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001964
name: Binding of Wise and Arrow/LRP5/6 in extracellular
xref_analog: IMR:0001162
xref_analog: IMR:0002951
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001965
name: Internalization of Arrow/LRP5/6
xref_analog: IMR:0002951
is_a: IEV:0001505 ! Receptor internalization
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001966
name: Internalization of LRP6
xref_analog: IMR:0000970
is_a: IEV:0001965 ! Internalization of Arrow/LRP5/6
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001967
name: Complex formation of Axin, APC, GSK-3 and Beta catenin in cytosol
xref_analog: IMR:0000177
xref_analog: IMR:0000205
xref_analog: IMR:0000257
xref_analog: IMR:0000432
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001968
name: Complex formation of Axin, APC, GSK-3, CK1alpha and beta catenin in cytosol
xref_analog: IMR:0000177
xref_analog: IMR:0000205
xref_analog: IMR:0000257
xref_analog: IMR:0000432
xref_analog: IMR:0100810
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001969
name: Phosphorylation of beta-catenin by CK1alpha in cytosol
xref_analog: IMR:0000177
xref_analog: IMR:0100810
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001970
name: Phosphorylation of beta-catenin by GSK-3 in cytosol
xref_analog: IMR:0000177
xref_analog: IMR:0000257
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001971
name: Ubiquitination of beta-catenin by SCF ubiquitin ligase complex in cytosol
alt_id: IEV:0001740
exact_synonym: "Ubiquitination of beta catenin" []
xref_analog: IMR:0000177
xref_analog: IMR:0100470
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0001739 ! Beta catenin degradation signaling

[Term]
id: IEV:0001972
name: Binding of Chibby and beta-catenin in inner space of nucleus
xref_analog: IMR:0000177
xref_analog: IMR:0001159
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001973
name: Binding of ICAT and beta-catenin in inner space of nucleus
xref_analog: IMR:0000177
xref_analog: IMR:0001161
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001974
name: Phosphorylation of TCF by NLK in inner space of nucleus
xref_analog: IMR:0000418
xref_analog: IMR:0001164
is_a: IEV:0001082 ! Phosphorylation in inner space of nucleus
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001975
name: Binding of Groucho and TCF in inner space of nucleus
xref_analog: IMR:0000418
xref_analog: IMR:0100748
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001976
name: Nuclear export of TCF
xref_analog: IMR:0000418
is_a: IEV:0000019 ! Nuclear export
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001977
name: Binding of IRS and PI3K in cytosol
xref_analog: IMR:0000265
xref_analog: IMR:0000351
xref_analog: PubMed:11282018
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000452 ! Insulin receptor signaling pathway (through IRS mediated signaling)
relationship: part_of IEV:0001979 ! PI3K activation signaling (through IRS)

[Term]
id: IEV:0001978
name: PI3K activation signaling (through Estrogen receptor)
is_a: IEV:0001227 ! PI3K activation signaling

[Term]
id: IEV:0001979
name: PI3K activation signaling (through IRS)
is_a: IEV:0001227 ! PI3K activation signaling

[Term]
id: IEV:0001980
name: Dissociation of IRAK1_p and TRAF6 in cytosol
xref_analog: IMR:0000890
xref_analog: IMR:0100427
xref_analog: PubMed:12620219
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0001981
name: Binding of G alpha-GDP and G beta:G gamma in cytosol
xref_analog: IMR:0000316
xref_analog: IMR:0001357
xref_analog: IMR:0100018
xref_analog: PubMed:14734786
is_a: IEV:0002074 ! Binding of G alpha-GDP and effector in cytosol
relationship: part_of IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0001982
name: Binding of G alpha s-GDP and G beta:G gamma in cytosol
xref_analog: IMR:0001357
xref_analog: IMR:0100018
xref_analog: IMR:0100366
xref_analog: PubMed:14734786
is_a: IEV:0001981 ! Binding of G alpha-GDP and G beta:G gamma in cytosol
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)
relationship: part_of IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
relationship: part_of IEV:0002637 ! Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)

[Term]
id: IEV:0001983
name: Binding of GPCR and G alpha in cytosol
xref_analog: IMR:0000137
xref_analog: IMR:0000316
xref_analog: PubMed:14734786
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002012 ! G alpha GDP-GTP exchange signaling

[Term]
id: IEV:0001984
name: Binding of GPCR and G alpha s in cytosol
xref_analog: IMR:0000137
xref_analog: IMR:0100366
xref_analog: PubMed:14734786
is_a: IEV:0001983 ! Binding of GPCR and G alpha in cytosol
relationship: part_of IEV:0002003 ! G alpha s GDP-GTP exchange signaling

[Term]
id: IEV:0001985
name: Binding of G beta:G gamma and PI3K gamma
comment: Free Gbetagamma can directly bind the regulatory p101 of PI3K gamma, leading to PI3K activation.
xref_analog: IMR:0100018
xref_analog: IMR:0200776
xref_analog: PubMed:14734786
is_a: IEV:0000186 ! Binding in unidentified cellular location
relationship: part_of IEV:0001987 ! PI3K gamma activation singlaing

[Term]
id: IEV:0001987
name: PI3K gamma activation singlaing
is_a: IEV:0001227 ! PI3K activation signaling

[Term]
id: IEV:0001988
name: cAMP mediated signaling
def: "A series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GO:0019933]
exact_synonym: "3',5' cAMP-mediated signaling" []
exact_synonym: "3',5'-cAMP-mediated signaling" []
exact_synonym: "adenosine 3',5'-cyclophosphate-mediated signaling" []
exact_synonym: "cAMP signaling" []
exact_synonym: "cAMP-mediated signaling" []
exact_synonym: "cyclic AMP-mediated signaling" []
xref_analog: GO:0019933
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0001989
name: Epac activation signaling
comment: Epac:Rap guanine nucleotide exchange factor by cAMP.
is_a: IEV:0001988 ! cAMP mediated signaling

[Term]
id: IEV:0001990
name: Cyclic nucleotide-gated cannel activation signaling
is_a: IEV:0001988 ! cAMP mediated signaling

[Term]
id: IEV:0001991
name: Phosphorylation of PI3K by JAK3_p in cytosol
xref_analog: IMR:0000265
xref_analog: IMR:0100321
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000140 ! IL7 signaling (JAK1, JAK3, STAT5)

[Term]
id: IEV:0001992
name: Binding of G alpha s-GTP and effector in cytosol
xref_analog: IMR:0001354
xref_analog: IMR:0100366
is_a: IEV:0000666 ! Binding of G alpha-GTP and effector in cytosol
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)

[Term]
id: IEV:0001993
name: Binding of G alpha s-GTP and Src family in cytosol
xref_analog: IMR:0000211
xref_analog: IMR:0001354
xref_analog: IMR:0100366
xref_analog: PubMed:14734786
is_a: IEV:0001992 ! Binding of G alpha s-GTP and effector in cytosol

[Term]
id: IEV:0001994
name: Binding of G beta gamma and GRK2/3
xref_analog: PubMed:14734786
is_obsolete: true

[Term]
id: IEV:0001995
name: Binding of G beta gamma and calcium ion channel
is_obsolete: true

[Term]
id: IEV:0001996
name: Binding of G beta gamma and sodium ion channel
xref_analog: PubMed:14734786
is_obsolete: true

[Term]
id: IEV:0001997
name: Binding of G alpha i-GTP and effector in cytosol
xref_analog: IMR:0000319
xref_analog: IMR:0001354
is_a: IEV:0000666 ! Binding of G alpha-GTP and effector in cytosol
relationship: part_of IEV:0000692 ! Heterotrimeric GPCR signaling pathway (through G alpha i)

[Term]
id: IEV:0001998
name: Binding of G alpha o-GTP and effector in cytosol
xref_analog: IMR:0000320
xref_analog: IMR:0001354
is_a: IEV:0000666 ! Binding of G alpha-GTP and effector in cytosol
relationship: part_of IEV:0000773 ! Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o and PLCbeta)

[Term]
id: IEV:0001999
name: Binding of G alpha i-GTP and PLC beta
xref_analog: PubMed:14734786
is_obsolete: true

[Term]
id: IEV:0002000
name: Binding of G alpha 11-GTP and PLC beta in cytosol
xref_analog: IMR:0000286
xref_analog: IMR:0001354
xref_analog: IMR:0100375
xref_analog: PubMed:14734786
is_a: IEV:0002014 ! Binding of G alpha 11-GTP and effector in cytosol

[Term]
id: IEV:0002001
name: Binding of G alpha 12/13-GTP and RhoGEF in cytosol
xref_analog: IMR:0000324
xref_analog: IMR:0001354
xref_analog: IMR:0001954
xref_analog: PubMed:14734786
is_a: IEV:0003862 ! Binding of G alpha 12/13-GTP and effector in cytosol

[Term]
id: IEV:0002002
name: Negative regulation of (Binding of G alpha s-GTP and adenylate cyclase)
xref_analog: IMR:0000313
is_a: IEV:0000693 ! Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
is_a: IEV:0002006 ! Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)

[Term]
id: IEV:0002003
name: G alpha s GDP-GTP exchange signaling
exact_synonym: "G alpha s activation signaling" []
is_a: IEV:0002012 ! G alpha GDP-GTP exchange signaling
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)
relationship: part_of IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
relationship: part_of IEV:0002637 ! Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)

[Term]
id: IEV:0002004
name: Negative regulation of (G alpha s GDP-GTP exchange signaling)
is_a: IEV:0000693 ! Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
is_a: IEV:0002006 ! Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)

[Term]
id: IEV:0002005
name: Regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
is_a: IEV:0000668 ! Regulation of heterotrimeric GPCR signaling pathway
relationship: regulates IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)

[Term]
id: IEV:0002006
name: Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
is_a: IEV:0000669 ! Negative regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0002005 ! Regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
relationship: negatively_regulates IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)

[Term]
id: IEV:0002007
name: Positive regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
is_a: IEV:0000670 ! Positive regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0002005 ! Regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
relationship: positively_regulates IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)

[Term]
id: IEV:0002008
name: Regulation of G alpha s-GTP hydrolysis signaling
is_a: IEV:0003682 ! Regulation of G alpha-GTP hydrolysis signaling
relationship: regulates IEV:0000702 ! G alpha s-GTP hydrolysis signaling

[Term]
id: IEV:0002009
name: Negative regulation of G alpha s-GTP hydrolysis signaling
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
is_a: IEV:0002008 ! Regulation of G alpha s-GTP hydrolysis signaling
relationship: negatively_regulates IEV:0000702 ! G alpha s-GTP hydrolysis signaling

[Term]
id: IEV:0002010
name: Positive regulation of G alpha s-GTP hydrolysis signaling
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
is_a: IEV:0002008 ! Regulation of G alpha s-GTP hydrolysis signaling
relationship: positively_regulates IEV:0000702 ! G alpha s-GTP hydrolysis signaling

[Term]
id: IEV:0002011
name: Negative regulation of (Hydrolysis of GTP by G alpha s-GTP and RGS) (through G alpha s GDP-GTP exchange signaling)
xref_analog: IMR:0000431
is_a: IEV:0002009 ! Negative regulation of G alpha s-GTP hydrolysis signaling

[Term]
id: IEV:0002012
name: G alpha GDP-GTP exchange signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0002013
name: Binding of G alpha t-GTP and effector in cytosol
xref_analog: IMR:0000321
xref_analog: IMR:0001354
is_a: IEV:0000666 ! Binding of G alpha-GTP and effector in cytosol

[Term]
id: IEV:0002014
name: Binding of G alpha 11-GTP and effector in cytosol
xref_analog: IMR:0001354
xref_analog: IMR:0100375
is_a: IEV:0000666 ! Binding of G alpha-GTP and effector in cytosol

[Term]
id: IEV:0002015
name: Binding of G alpha 12/13-GTP and PLC beta in cytosol
xref_analog: IMR:0000286
xref_analog: IMR:0000324
xref_analog: IMR:0001354
is_a: IEV:0003862 ! Binding of G alpha 12/13-GTP and effector in cytosol

[Term]
id: IEV:0002016
name: Binding of G alpha q-GTP and effector in cytosol
xref_analog: IMR:0001354
xref_analog: IMR:0100378
is_a: IEV:0000666 ! Binding of G alpha-GTP and effector in cytosol

[Term]
id: IEV:0002017
name: G alpha i GDP-GTP exchange signaling
is_a: IEV:0002012 ! G alpha GDP-GTP exchange signaling
relationship: part_of IEV:0000692 ! Heterotrimeric GPCR signaling pathway (through G alpha i)

[Term]
id: IEV:0002018
name: Binding of GPCR and G alpha i in cytosol
xref_analog: IMR:0000137
xref_analog: IMR:0000319
xref_analog: PubMed:14734786
is_a: IEV:0001983 ! Binding of GPCR and G alpha in cytosol
relationship: part_of IEV:0002017 ! G alpha i GDP-GTP exchange signaling

[Term]
id: IEV:0002019
name: Binding of G alpha i-GDP and G beta:G gamma in cytosol
xref_analog: IMR:0000319
xref_analog: IMR:0001357
xref_analog: IMR:0100018
xref_analog: PubMed:14734786
is_a: IEV:0001981 ! Binding of G alpha-GDP and G beta:G gamma in cytosol

[Term]
id: IEV:0002020
name: Negative regulation of (Binding of G alpha i-GTP and adenylate cyclase)
xref_analog: IMR:0000313
is_a: IEV:0002026 ! Negative regulation of heteromeric GPCR signaling pathway (through G alpha i)

[Term]
id: IEV:0002021
name: Adenylate cyclase activation signaling
def: "Any process that initiates the activity of the inactive enzyme adenylate cyclase." [GO:0007190]
exact_synonym: "adenylate cyclase activation" []
xref_analog: GO:0007190
xref_analog: PubMed:14734786
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0000780 ! PKA activation signaling
relationship: part_of IEV:0002020 ! Negative regulation of (Binding of G alpha i-GTP and adenylate cyclase)

[Term]
id: IEV:0002022
name: Adenylate cyclase inactivation signaling
xref_analog: PubMed:14734786
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0000692 ! Heterotrimeric GPCR signaling pathway (through G alpha i)

[Term]
id: IEV:0002023
name: Positive regulation of G alpha i-GTP hydrolysis signaling
is_a: IEV:0002024 ! Regulation of G alpha i-GTP hydrolysis signaling
relationship: positively_regulates IEV:0000701 ! G alpha i-GTP hydrolysis signaling

[Term]
id: IEV:0002024
name: Regulation of G alpha i-GTP hydrolysis signaling
is_a: IEV:0003682 ! Regulation of G alpha-GTP hydrolysis signaling
relationship: regulates IEV:0000701 ! G alpha i-GTP hydrolysis signaling

[Term]
id: IEV:0002025
name: Positive regulation of heteromeric GPCR signaling pathway (through G alpha i and pertussis toxin)
is_a: IEV:0000670 ! Positive regulation of heterotrimeric GPCR signaling pathway

[Term]
id: IEV:0002026
name: Negative regulation of heteromeric GPCR signaling pathway (through G alpha i)
is_a: IEV:0000669 ! Negative regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000730 ! Regulation of heterotrimeric GPCR signaling pathway (through G alpha i)
relationship: negatively_regulates IEV:0000692 ! Heterotrimeric GPCR signaling pathway (through G alpha i)

[Term]
id: IEV:0002027
name: Negative regulation of (Binding of GPCR and G alpha i)
is_obsolete: true

[Term]
id: IEV:0002028
name: cAMP concentration elevation
is_a: IEV:0000771 ! Change in material concentration

[Term]
id: IEV:0002029
name: cAMP concentration decline
is_a: IEV:0000771 ! Change in material concentration

[Term]
id: IEV:0002030
name: Negative regulation of (Binding of GPCR ligand and GPCR)
xref_analog: IMR:0000137
is_a: IEV:0002026 ! Negative regulation of heteromeric GPCR signaling pathway (through G alpha i)

[Term]
id: IEV:0002031
name: G alpha q GDP-GTP exchange signaling
is_a: IEV:0002012 ! G alpha GDP-GTP exchange signaling
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
relationship: part_of IEV:0002633 ! Heterotrimeric GPCR signaling pathway (through Angiotensin and G alpha q)
relationship: part_of IEV:0002653 ! Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)

[Term]
id: IEV:0002032
name: Binding of G alpha q-GDP and G beta:G gamma in cytosol
xref_analog: IMR:0001357
xref_analog: IMR:0100018
xref_analog: IMR:0100378
xref_analog: PubMed:14734786
is_a: IEV:0001981 ! Binding of G alpha-GDP and G beta:G gamma in cytosol
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
relationship: part_of IEV:0002633 ! Heterotrimeric GPCR signaling pathway (through Angiotensin and G alpha q)
relationship: part_of IEV:0002653 ! Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)

[Term]
id: IEV:0002033
name: Negative regulation of G alpha i-GTP hydrolysis signaling
is_a: IEV:0002024 ! Regulation of G alpha i-GTP hydrolysis signaling
relationship: negatively_regulates IEV:0000701 ! G alpha i-GTP hydrolysis signaling

[Term]
id: IEV:0002034
name: Negative regulation of (Hydrolysis of GTP by G alpha i-GTP and RGS)
xref_analog: IMR:0000431
is_a: IEV:0002033 ! Negative regulation of G alpha i-GTP hydrolysis signaling

[Term]
id: IEV:0002035
name: Regulation of G alpha q-GTP hydrolysis signaling
is_a: IEV:0003682 ! Regulation of G alpha-GTP hydrolysis signaling
relationship: regulates IEV:0000754 ! G alpha q-GTP hydrolysis signaling

[Term]
id: IEV:0002036
name: Negative regulation of G alpha q-GTP hydrolysis signaling
is_a: IEV:0002035 ! Regulation of G alpha q-GTP hydrolysis signaling
relationship: negatively_regulates IEV:0000754 ! G alpha q-GTP hydrolysis signaling

[Term]
id: IEV:0002037
name: Negative regulation of (Hydrolysis of GTP by G alpha q-GTP and RGS)
xref_analog: IMR:0000431
xref_analog: IMR:0100378
is_a: IEV:0002036 ! Negative regulation of G alpha q-GTP hydrolysis signaling

[Term]
id: IEV:0002038
name: Positive regulation of G alpha q-GTP hydrolysis signaling
is_a: IEV:0002035 ! Regulation of G alpha q-GTP hydrolysis signaling
relationship: positively_regulates IEV:0000754 ! G alpha q-GTP hydrolysis signaling

[Term]
id: IEV:0002039
name: Regulation of G alpha t-GTP hydrolysis signaling
is_a: IEV:0003682 ! Regulation of G alpha-GTP hydrolysis signaling
relationship: regulates IEV:0000735 ! G alpha t-GTP hydrolysis signaling

[Term]
id: IEV:0002040
name: Positive regulation of G alpha t-GTP hydrolysis signaling
is_a: IEV:0002039 ! Regulation of G alpha t-GTP hydrolysis signaling
relationship: positively_regulates IEV:0000735 ! G alpha t-GTP hydrolysis signaling

[Term]
id: IEV:0002041
name: Negative regulation of G alpha t-GTP hydrolysis signaling
is_a: IEV:0002039 ! Regulation of G alpha t-GTP hydrolysis signaling
relationship: negatively_regulates IEV:0000735 ! G alpha t-GTP hydrolysis signaling

[Term]
id: IEV:0002042
name: Negative regulation of (Hydrolysis of GTP by G alpha t-GTP and RGS)
xref_analog: IMR:0000431
is_a: IEV:0002041 ! Negative regulation of G alpha t-GTP hydrolysis signaling

[Term]
id: IEV:0002043
name: G alpha t GDP-GTP exchange signaling
is_a: IEV:0002012 ! G alpha GDP-GTP exchange signaling

[Term]
id: IEV:0002044
name: Regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0003681 ! signal transduction regulation pathway
relationship: regulates IEV:0002012 ! G alpha GDP-GTP exchange signaling

[Term]
id: IEV:0002045
name: Regulation of G alpha s GDP-GTP exchange signaling
is_a: IEV:0002044 ! Regulation of G alpha GDP-GTP exchange signaling
relationship: regulates IEV:0002003 ! G alpha s GDP-GTP exchange signaling

[Term]
id: IEV:0002046
name: Negative regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
is_a: IEV:0002044 ! Regulation of G alpha GDP-GTP exchange signaling
relationship: negatively_regulates IEV:0002012 ! G alpha GDP-GTP exchange signaling

[Term]
id: IEV:0002047
name: Positive regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
is_a: IEV:0002044 ! Regulation of G alpha GDP-GTP exchange signaling
relationship: positively_regulates IEV:0002012 ! G alpha GDP-GTP exchange signaling

[Term]
id: IEV:0002048
name: Regulation of G alpha i GDP-GTP exchange signaling
is_a: IEV:0002044 ! Regulation of G alpha GDP-GTP exchange signaling
relationship: regulates IEV:0002017 ! G alpha i GDP-GTP exchange signaling

[Term]
id: IEV:0002049
name: Regulation of G alpha q GDP-GTP exchange signaling
is_a: IEV:0002044 ! Regulation of G alpha GDP-GTP exchange signaling
relationship: regulates IEV:0002031 ! G alpha q GDP-GTP exchange signaling

[Term]
id: IEV:0002050
name: Regulation of G alpha t GDP-GTP exchange signaling
is_a: IEV:0002044 ! Regulation of G alpha GDP-GTP exchange signaling
relationship: regulates IEV:0002043 ! G alpha t GDP-GTP exchange signaling

[Term]
id: IEV:0002051
name: Negative regulation of G alpha i GDP-GTP exchange signaling
is_a: IEV:0002046 ! Negative regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0002048 ! Regulation of G alpha i GDP-GTP exchange signaling
relationship: negatively_regulates IEV:0002017 ! G alpha i GDP-GTP exchange signaling

[Term]
id: IEV:0002052
name: Negative regulation of G alpha q GDP-GTP exchange signaling
is_a: IEV:0002046 ! Negative regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0002049 ! Regulation of G alpha q GDP-GTP exchange signaling
relationship: negatively_regulates IEV:0002031 ! G alpha q GDP-GTP exchange signaling

[Term]
id: IEV:0002053
name: Negative regulation of G alpha s GDP-GTP exchange signaling
is_a: IEV:0002045 ! Regulation of G alpha s GDP-GTP exchange signaling
is_a: IEV:0002046 ! Negative regulation of G alpha GDP-GTP exchange signaling
relationship: negatively_regulates IEV:0002003 ! G alpha s GDP-GTP exchange signaling

[Term]
id: IEV:0002054
name: Negative regulation of G alpha t GDP-GTP exchange signaling
is_a: IEV:0002046 ! Negative regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0002050 ! Regulation of G alpha t GDP-GTP exchange signaling
relationship: negatively_regulates IEV:0002043 ! G alpha t GDP-GTP exchange signaling

[Term]
id: IEV:0002055
name: Positive regulation of G alpha i GDP-GTP exchange signaling
is_a: IEV:0002047 ! Positive regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0002048 ! Regulation of G alpha i GDP-GTP exchange signaling
relationship: positively_regulates IEV:0002017 ! G alpha i GDP-GTP exchange signaling

[Term]
id: IEV:0002056
name: Positive regulation of G alpha q GDP-GTP exchange signaling
is_a: IEV:0002047 ! Positive regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0002049 ! Regulation of G alpha q GDP-GTP exchange signaling
relationship: positively_regulates IEV:0002031 ! G alpha q GDP-GTP exchange signaling

[Term]
id: IEV:0002057
name: Positive regulation of G alpha s GDP-GTP exchange signaling
is_a: IEV:0002045 ! Regulation of G alpha s GDP-GTP exchange signaling
is_a: IEV:0002047 ! Positive regulation of G alpha GDP-GTP exchange signaling
relationship: positively_regulates IEV:0002003 ! G alpha s GDP-GTP exchange signaling

[Term]
id: IEV:0002058
name: Positive regulation of G alpha t GDP-GTP exchange signaling
is_a: IEV:0002047 ! Positive regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0002050 ! Regulation of G alpha t GDP-GTP exchange signaling
relationship: positively_regulates IEV:0002043 ! G alpha t GDP-GTP exchange signaling

[Term]
id: IEV:0002059
name: Negative regulation of (GDP-GTP exchange of G alpha)
xref_analog: IMR:0001357
is_a: IEV:0002046 ! Negative regulation of G alpha GDP-GTP exchange signaling

[Term]
id: IEV:0002060
name: Negative regulation of (GDP-GTP exchange of G alpha i)
xref_analog: IMR:0001357
is_a: IEV:0002051 ! Negative regulation of G alpha i GDP-GTP exchange signaling

[Term]
id: IEV:0002061
name: Negative regulation of (GDP-GTP exchange of G alpha q)
xref_analog: IMR:0001357
xref_analog: IMR:0100378
is_a: IEV:0002052 ! Negative regulation of G alpha q GDP-GTP exchange signaling

[Term]
id: IEV:0002062
name: Negative regulation of (GDP-GTP exchange of G alpha s)
xref_analog: IMR:0001357
is_a: IEV:0002053 ! Negative regulation of G alpha s GDP-GTP exchange signaling

[Term]
id: IEV:0002063
name: Negative regulation of (GDP-GTP exchange of G alpha t)
xref_analog: IMR:0001357
is_a: IEV:0002054 ! Negative regulation of G alpha t GDP-GTP exchange signaling

[Term]
id: IEV:0002064
name: Binding of GPCR and G alpha q in cytosol
xref_analog: IMR:0000137
xref_analog: IMR:0100378
xref_analog: PubMed:14734786
is_a: IEV:0001983 ! Binding of GPCR and G alpha in cytosol
relationship: part_of IEV:0002031 ! G alpha q GDP-GTP exchange signaling

[Term]
id: IEV:0002065
name: Binding of GPCR and G alpha t in cytosol
xref_analog: IMR:0000137
xref_analog: IMR:0000321
xref_analog: PubMed:14734786
is_a: IEV:0001983 ! Binding of GPCR and G alpha in cytosol
relationship: part_of IEV:0002043 ! G alpha t GDP-GTP exchange signaling

[Term]
id: IEV:0002066
name: Negative regulation of (Hydrolysis of GTP by G alpha s-GTP and RGS) (through Adenylate cyclase activation signaling)
xref_analog: IMR:0000431
is_a: IEV:0002009 ! Negative regulation of G alpha s-GTP hydrolysis signaling

[Term]
id: IEV:0002067
name: Phosphorylation of MAPK by MEK in cytosol
xref_analog: IMR:0000224
xref_analog: IMR:0000259
is_a: IEV:0000478 ! Phosphorylation of MAPK by MAPKK in cytosol

[Term]
id: IEV:0002068
name: Activation of B-Raf by Rap1 in cytosol
xref_analog: IMR:0000675
xref_analog: IMR:0001504
xref_analog: PubMed:11752597
xref_analog: PubMed:9247123
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0002084 ! B-Raf activation signaling

[Term]
id: IEV:0002069
name: Binding of Rap1 and B-Raf in cytosol
xref_analog: IMR:0000675
xref_analog: IMR:0001504
xref_analog: PubMed:11752597
xref_analog: PubMed:9560161
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)

[Term]
id: IEV:0002070
name: Binding of Rap1 and Crk
xref_analog: PubMed:9560161
is_obsolete: true

[Term]
id: IEV:0002071
name: GDP-GTP exchange of Rap1 by Epac1 in cytosol
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: IMR:0001504
xref_analog: IMR:0001968
xref_analog: PubMed:11752597
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0002080 ! Rap1 activation signaling (through cAMP and Epac)

[Term]
id: IEV:0002072
name: Raf activation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling

[Term]
id: IEV:0002073
name: Activation of Epac by cAMP in cytosol
xref_analog: IMR:0001967
xref_analog: IMR:0100024
xref_analog: PubMed:9853756
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0002080 ! Rap1 activation signaling (through cAMP and Epac)

[Term]
id: IEV:0002074
name: Binding of G alpha-GDP and effector in cytosol
xref_analog: IMR:0000316
xref_analog: IMR:0001357
is_a: IEV:0000013 ! Binding in cytosol

[Term]
id: IEV:0002075
name: Binding of G alpha o -GDP and Rap1GAP1 in cytosol
xref_analog: IMR:0000320
xref_analog: IMR:0001357
xref_analog: PubMed:10419452
xref_analog: UniProt:P47736
is_a: IEV:0002074 ! Binding of G alpha-GDP and effector in cytosol

[Term]
id: IEV:0002076
name: Binding of G alpha i-GTP and Rap1GAP2 in cytosol
xref_analog: IMR:0000319
xref_analog: IMR:0001354
xref_analog: PubMed:10476970
xref_analog: UniProt:Q684P5
is_a: IEV:0001997 ! Binding of G alpha i-GTP and effector in cytosol
relationship: part_of IEV:0002085 ! Negative regulation of (GDP-GTP exchange of Rap1 by Epac1)

[Term]
id: IEV:0002077
name: Binding of G alpha z-GTP and effector in cytosol
xref_analog: IMR:0000322
xref_analog: IMR:0001354
is_a: IEV:0000666 ! Binding of G alpha-GTP and effector in cytosol

[Term]
id: IEV:0002078
name: Binding of G alpha z-GTP and Rap1GAP1 in cytosol
xref_analog: IMR:0000322
xref_analog: IMR:0001354
xref_analog: PubMed:10593970
xref_analog: UniProt:P47736
is_a: IEV:0002077 ! Binding of G alpha z-GTP and effector in cytosol

[Term]
id: IEV:0002079
name: Rap1 activation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0002084 ! B-Raf activation signaling

[Term]
id: IEV:0002080
name: Rap1 activation signaling (through cAMP and Epac)
xref_analog: PubMed:11752597
is_a: IEV:0002079 ! Rap1 activation signaling

[Term]
id: IEV:0002081
name: Rap1 activation signaling (through cAMP, PKA, Cbl and C3G)
xref_analog: PubMed:11804588
is_a: IEV:0002079 ! Rap1 activation signaling

[Term]
id: IEV:0002082
name: Phosphorylation of Src by PKA in cytosol
xref_analog: IMR:0000249
xref_analog: IMR:0100575
xref_analog: PubMed:11804588
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0002081 ! Rap1 activation signaling (through cAMP, PKA, Cbl and C3G)

[Term]
id: IEV:0002083
name: Phosphorylation of Cbl by Src in cytosol
xref_analog: IMR:0000356
xref_analog: IMR:0100575
xref_analog: PubMed:11804588
xref_analog: PubMed:15345216
xref_analog: PubMed:20584982
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0002081 ! Rap1 activation signaling (through cAMP, PKA, Cbl and C3G)

[Term]
id: IEV:0002084
name: B-Raf activation signaling
is_a: IEV:0002072 ! Raf activation signaling
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)

[Term]
id: IEV:0002085
name: Negative regulation of (GDP-GTP exchange of Rap1 by Epac1)
xref_analog: IMR:0001357
xref_analog: IMR:0001504
xref_analog: IMR:0001968
is_a: IEV:0000693 ! Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s)

[Term]
id: IEV:0002086
name: Phosphorylation of MAPKKK by non-receptor serine/threonine kinase in cytosol
xref_analog: IMR:0000229
xref_analog: IMR:0000681
is_a: IEV:0000025 ! Phosphorylation in cytosol

[Term]
id: IEV:0002087
name: Phosphorylation of Raf by PKC in cytosol
xref_analog: IMR:0000231
xref_analog: IMR:0000245
xref_analog: PubMed:8321321
is_a: IEV:0002086 ! Phosphorylation of MAPKKK by non-receptor serine/threonine kinase in cytosol
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
relationship: part_of IEV:0001362 ! Activation of Raf by PKC in cytosol
relationship: part_of IEV:0002653 ! Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)

[Term]
id: IEV:0002088
name: Phosphorylation of MEK1/2(MKK1/2) by B-Raf in cytosol
xref_analog: IMR:0000261
xref_analog: IMR:0000675
xref_analog: PubMed:11752597
is_a: IEV:0000820 ! Phosphorylation of MEK1/2(MKK1/2) by Raf in cytosol

[Term]
id: IEV:0002089
name: Rap1 inactivation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0002085 ! Negative regulation of (GDP-GTP exchange of Rap1 by Epac1)

[Term]
id: IEV:0002090
name: Hydrolysis of GTP by RapGAP in cytosol
xref_analog: IMR:0001354
is_a: IEV:0003828 ! Hydrolysis of GTP by small GTPase and GAP in cytosol
relationship: part_of IEV:0002089 ! Rap1 inactivation signaling

[Term]
id: IEV:0002091
name: Hydrolysis of GTP by Rap1GAP1 in cytosol
xref_analog: IMR:0001354
xref_analog: PubMed:11752597
xref_analog: UniProt:P47736
is_a: IEV:0002090 ! Hydrolysis of GTP by RapGAP in cytosol

[Term]
id: IEV:0002092
name: Hydrolysis of GTP by Rap1GAP2 in cytosol
xref_analog: IMR:0001354
xref_analog: PubMed:11752597
xref_analog: UniProt:Q684P5
is_a: IEV:0002090 ! Hydrolysis of GTP by RapGAP in cytosol

[Term]
id: IEV:0002093
name: Binding of Crk and Cbl in cytosol
xref_analog: IMR:0000335
xref_analog: IMR:0000356
xref_analog: PubMed:11804588
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002081 ! Rap1 activation signaling (through cAMP, PKA, Cbl and C3G)

[Term]
id: IEV:0002095
name: Phosphorylation of JNK by MKK_p in cytosol
def: "The initiation of the activity of the inactive enzyme JUN kinase by phosphorylation by a JUN kinase kinase (JNKK)." [GO:0007257]
exact_synonym: "activation of JNK activity" []
xref_analog: GO:0007257
xref_analog: IMR:0000225
xref_analog: IMR:0000259
is_a: IEV:0000478 ! Phosphorylation of MAPK by MAPKK in cytosol
relationship: part_of IEV:0000226 ! JNK cascade

[Term]
id: IEV:0002096
name: Dissociation of cytokine receptor and STAT in cytosol
xref_analog: IMR:0000095
xref_analog: IMR:0000374
xref_analog: PubMed:12039028
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0002097
name: Binding of AP-1 and responsive element in inner space of nucleus
xref_analog: IGS:0000028
xref_analog: IMR:0000414
is_a: IEV:0002098 ! Binding of transcription factor and responsive element in inner space of nucleus
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000225 ! Gene expression of cytokine by AP-1
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0002098
name: Binding of transcription factor and responsive element in inner space of nucleus
exact_synonym: "Binding of transcription factor and responsive element in inner space of nucleus" []
xref_analog: IGS:0000028
xref_analog: IMR:0000368
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000182 ! Gene expression

[Term]
id: IEV:0002099
name: Transcription of cytokine by AP-1 in nucleus
xref_analog: IMR:0000006
xref_analog: IMR:0000414
is_a: IEV:0003388 ! Transcription by AP-1 in nucleus
relationship: part_of IEV:0000225 ! Gene expression of cytokine by AP-1

[Term]
id: IEV:0002100
name: Binding of STAT dimer and GAS in inner space of nucleus
xref_analog: IGS:0000018
xref_analog: IMR:0000374
xref_analog: PubMed:12039028
is_a: IEV:0000049 ! Binding of STAT dimer and responsive element in inner space of nucleus

[Term]
id: IEV:0002101
name: Gene expression of SOCS by STAT dimer
alt_id: IEV:0000144
alt_id: IEV:0002234
exact_synonym: "Gene expression of CIS family" []
exact_synonym: "Gene expression of CIS by STAT dimer" []
xref_analog: IMR:0000374
xref_analog: IMR:0000460
xref_analog: PubMed:14607831
is_a: IEV:0002102 ! Gene expression by STAT dimer
relationship: part_of IEV:0000143 ! Negative feedback regulation of JAK STAT pathway by (binding of SOCS and JAK)
relationship: part_of IEV:0000151 ! Negative feedback regulation of JAK STAT pathway by (binding of SOCS and cytokine receptor)
relationship: part_of IEV:0002223 ! Negative feedback regulation of JAK STAT pathway by (cytokine receptor degradation signaling)

[Term]
id: IEV:0002102
name: Gene expression by STAT dimer
xref_analog: IMR:0000374
xref_analog: PubMed:14607831
is_a: IEV:0000233 ! Gene expression by transcriptional regulator
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0002103
name: Transcription of SOCS by STAT dimer in nucleus
alt_id: IEV:0002237
exact_synonym: "Transcription of CIS by STAT dimer in nucleus" []
xref_analog: IMR:0000374
xref_analog: IMR:0000460
xref_analog: PubMed:14607831
is_a: IEV:0000050 ! Transcription by STAT dimer in nucleus
relationship: part_of IEV:0002101 ! Gene expression of SOCS by STAT dimer

[Term]
id: IEV:0002104
name: Translation of SOCS in cytosol
alt_id: IEV:0002236
exact_synonym: "Translation of CIS in cytosol" []
xref_analog: IMR:0000460
xref_analog: PubMed:14607831
is_a: IEV:0003550 ! Translation in cytosol
relationship: part_of IEV:0002101 ! Gene expression of SOCS by STAT dimer

[Term]
id: IEV:0002105
name: Nuclear export of mRNA (SOCS)
alt_id: IEV:0002235
exact_synonym: "Nuclear export of mRNA (CIS)" []
xref_analog: IMR:0000460
xref_analog: PubMed:14607831
is_a: IEV:0000909 ! Nuclear export of mRNA
relationship: part_of IEV:0002101 ! Gene expression of SOCS by STAT dimer

[Term]
id: IEV:0002106
name: Phosphorylation of p38 by MKK_p in cytosol
xref_analog: IMR:0000226
xref_analog: IMR:0000259
is_a: IEV:0000478 ! Phosphorylation of MAPK by MAPKK in cytosol
relationship: part_of IEV:0000234 ! p38 cascade

[Term]
id: IEV:0002107
name: Binding of IFN alpha receptor and STAT2 in cytosol
xref_analog: IMR:0000135
xref_analog: IMR:0000376
xref_analog: PubMed:12040185
is_a: IEV:0000046 ! Binding of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0002263 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT2)

[Term]
id: IEV:0002108
name: Binding of IFN alpha receptor and STAT1 in cytosol
xref_analog: IMR:0000135
xref_analog: IMR:0000375
xref_analog: PubMed:15561601
is_a: IEV:0000046 ! Binding of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0002260 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1)
relationship: part_of IEV:0002261 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT3)

[Term]
id: IEV:0002109
name: Binding of IFN alpha receptor and STAT3 in cytosol
xref_analog: IMR:0000135
xref_analog: IMR:0000377
xref_analog: PubMed:15561601
is_a: IEV:0000046 ! Binding of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0002261 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT3)
relationship: part_of IEV:0002265 ! IFN alpha signaling pathway (JAK1, TYK2, STAT3)

[Term]
id: IEV:0002110
name: Binding of IFN gamma receptor and STAT1 in cytosol
xref_analog: IMR:0000136
xref_analog: IMR:0000375
xref_analog: PubMed:12040185
is_a: IEV:0000046 ! Binding of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0002264 ! IFN gamma signaling pathway (JAK1, JAK2, STAT1)

[Term]
id: IEV:0002111
name: Binding of IL-6 receptor and STAT3 in cytosol
xref_analog: IMR:0000104
xref_analog: IMR:0000377
xref_analog: PubMed:12040185
is_a: IEV:0000046 ! Binding of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0002259 ! IL6 signaling pathway (JAK1, JAK2, STAT3)

[Term]
id: IEV:0002112
name: Binding of IL-10 receptor and STAT3 in cytosol
xref_analog: IMR:0000377
xref_analog: IMR:0000608
xref_analog: PubMed:10433356
xref_analog: PubMed:12626585
is_a: IEV:0000046 ! Binding of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0000139 ! IL10 signaling (JAK1, TYK2, STAT3)

[Term]
id: IEV:0002113
name: Binding of IL-2 receptor and STAT5 in cytosol
xref_analog: IMR:0000097
xref_analog: IMR:0100733
xref_analog: PubMed:10920190
xref_analog: PubMed:11160217
is_a: IEV:0000046 ! Binding of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0000136 ! IL2 signaling (JAK1, JAK3, STAT5)

[Term]
id: IEV:0002114
name: Binding of IL-12 receptor and STAT4 in cytosol
xref_analog: IMR:0000378
xref_analog: IMR:0000602
xref_analog: PubMed:10415122
xref_analog: PubMed:12805384
is_a: IEV:0000046 ! Binding of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0000138 ! IL12 signaling pathway (JAK2, TYK2, STAT4)

[Term]
id: IEV:0002115
name: Nuclear import of ISGF3
exact_synonym: "Nuclear import of STAT1:STAT2:IRF9" []
xref_analog: IMR:0001422
xref_analog: PubMed:12040185
is_a: IEV:0000048 ! Nuclear import of STAT dimer
relationship: part_of IEV:0002263 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT2)

[Term]
id: IEV:0002116
name: Nuclear import of STAT1 homodimer
xref_analog: IMR:0000375
xref_analog: PubMed:12040185
is_a: IEV:0000048 ! Nuclear import of STAT dimer
relationship: part_of IEV:0000867 ! EPO signaling pathway
relationship: part_of IEV:0002260 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1)
relationship: part_of IEV:0002264 ! IFN gamma signaling pathway (JAK1, JAK2, STAT1)
relationship: part_of IEV:0003620 ! IL5 signaling pathway (JAK1, JAK2, STAT1, STAT5)

[Term]
id: IEV:0002117
name: Nuclear import of STAT3 homodimer
xref_analog: IMR:0000377
xref_analog: PubMed:10857556
xref_analog: PubMed:12040185
is_a: IEV:0000048 ! Nuclear import of STAT dimer
relationship: part_of IEV:0000139 ! IL10 signaling (JAK1, TYK2, STAT3)
relationship: part_of IEV:0000867 ! EPO signaling pathway
relationship: part_of IEV:0001233 ! TPO signaling pathway (JAK2, STAT3)
relationship: part_of IEV:0002259 ! IL6 signaling pathway (JAK1, JAK2, STAT3)
relationship: part_of IEV:0002262 ! LIF signaling pathway
relationship: part_of IEV:0002265 ! IFN alpha signaling pathway (JAK1, TYK2, STAT3)

[Term]
id: IEV:0002118
name: Nuclear import of STAT1:STAT3 heterodimer
xref_analog: IMR:0000375
xref_analog: IMR:0000377
xref_analog: PubMed:15561601
is_a: IEV:0000048 ! Nuclear import of STAT dimer
relationship: part_of IEV:0002261 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT3)

[Term]
id: IEV:0002119
name: Nuclear import of STAT5 homodimer
xref_analog: IMR:0100733
xref_analog: PubMed:11160217
xref_analog: PubMed:15561601
is_a: IEV:0000048 ! Nuclear import of STAT dimer
relationship: part_of IEV:0000135 ! IL3 signaling pathway (JAK1, JAK2, STAT5)
relationship: part_of IEV:0000136 ! IL2 signaling (JAK1, JAK3, STAT5)
relationship: part_of IEV:0000140 ! IL7 signaling (JAK1, JAK3, STAT5)
relationship: part_of IEV:0000867 ! EPO signaling pathway
relationship: part_of IEV:0003620 ! IL5 signaling pathway (JAK1, JAK2, STAT1, STAT5)

[Term]
id: IEV:0002120
name: Nuclear import of STAT4 homodimer
xref_analog: IMR:0000378
xref_analog: PubMed:12805384
xref_analog: PubMed:15004198
is_a: IEV:0000048 ! Nuclear import of STAT dimer
relationship: part_of IEV:0000138 ! IL12 signaling pathway (JAK2, TYK2, STAT4)

[Term]
id: IEV:0002121
name: Dimerization of STAT1 and STAT2 in cytosol
xref_analog: IMR:0000375
xref_analog: IMR:0000376
xref_analog: PubMed:11932384
is_a: IEV:0000047 ! Dimerization of STAT in cytosol
relationship: part_of IEV:0002263 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT2)

[Term]
id: IEV:0002122
name: Dimerization of STAT1 in cytosol
xref_analog: IMR:0000375
xref_analog: PubMed:12040185
xref_analog: PubMed:15561601
is_a: IEV:0000047 ! Dimerization of STAT in cytosol
relationship: part_of IEV:0000867 ! EPO signaling pathway
relationship: part_of IEV:0002260 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1)
relationship: part_of IEV:0002264 ! IFN gamma signaling pathway (JAK1, JAK2, STAT1)
relationship: part_of IEV:0003620 ! IL5 signaling pathway (JAK1, JAK2, STAT1, STAT5)

[Term]
id: IEV:0002123
name: Dimerization of STAT3 in cytosol
xref_analog: IMR:0000377
xref_analog: PubMed:10433356
xref_analog: PubMed:10857556
xref_analog: PubMed:12040185
is_a: IEV:0000047 ! Dimerization of STAT in cytosol
relationship: part_of IEV:0000139 ! IL10 signaling (JAK1, TYK2, STAT3)
relationship: part_of IEV:0000867 ! EPO signaling pathway
relationship: part_of IEV:0001233 ! TPO signaling pathway (JAK2, STAT3)
relationship: part_of IEV:0002259 ! IL6 signaling pathway (JAK1, JAK2, STAT3)
relationship: part_of IEV:0002262 ! LIF signaling pathway
relationship: part_of IEV:0002265 ! IFN alpha signaling pathway (JAK1, TYK2, STAT3)

[Term]
id: IEV:0002124
name: Dimerization of STAT1 and STAT3 in cytosol
xref_analog: IMR:0000375
xref_analog: IMR:0000377
xref_analog: PubMed:15561601
is_a: IEV:0000047 ! Dimerization of STAT in cytosol
relationship: part_of IEV:0002261 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT3)

[Term]
id: IEV:0002125
name: Dimerization of STAT5 in cytosol
xref_analog: IMR:0100733
xref_analog: PubMed:11160217
is_a: IEV:0000047 ! Dimerization of STAT in cytosol
relationship: part_of IEV:0000135 ! IL3 signaling pathway (JAK1, JAK2, STAT5)
relationship: part_of IEV:0000136 ! IL2 signaling (JAK1, JAK3, STAT5)
relationship: part_of IEV:0000867 ! EPO signaling pathway
relationship: part_of IEV:0003620 ! IL5 signaling pathway (JAK1, JAK2, STAT1, STAT5)

[Term]
id: IEV:0002126
name: Dimerization of STAT4 in cytosol
xref_analog: IMR:0000378
xref_analog: PubMed:15004198
is_a: IEV:0000047 ! Dimerization of STAT in cytosol
relationship: part_of IEV:0000138 ! IL12 signaling pathway (JAK2, TYK2, STAT4)

[Term]
id: IEV:0002127
name: Phosphorylation of STAT2 by JAK1_p and TYK2_p in cytosol
xref_analog: IMR:0000376
xref_analog: IMR:0100319
xref_analog: IMR:0100322
xref_analog: PubMed:12040185
is_a: IEV:0000446 ! Phosphorylation of STAT by JAK_p in cytosol
relationship: part_of IEV:0002263 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT2)

[Term]
id: IEV:0002128
name: Phosphorylation of STAT1 by JAK1_p and TYK2_p in cytosol
xref_analog: IMR:0000375
xref_analog: IMR:0100319
xref_analog: IMR:0100322
xref_analog: PubMed:12040185
xref_analog: PubMed:15561601
is_a: IEV:0000446 ! Phosphorylation of STAT by JAK_p in cytosol
relationship: part_of IEV:0002260 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1)
relationship: part_of IEV:0002261 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT3)
relationship: part_of IEV:0002263 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT2)

[Term]
id: IEV:0002129
name: Phosphorylation of STAT3 by JAK1_p and TYK2_p in cytosol
xref_analog: IMR:0000377
xref_analog: IMR:0100319
xref_analog: IMR:0100322
xref_analog: PubMed:10433356
xref_analog: PubMed:12626585
xref_analog: PubMed:15561601
is_a: IEV:0000446 ! Phosphorylation of STAT by JAK_p in cytosol
relationship: part_of IEV:0000139 ! IL10 signaling (JAK1, TYK2, STAT3)
relationship: part_of IEV:0002261 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT3)
relationship: part_of IEV:0002265 ! IFN alpha signaling pathway (JAK1, TYK2, STAT3)

[Term]
id: IEV:0002130
name: Phosphorylation of STAT3 by JAK1_p and JAK2_p in cytosol
xref_analog: IMR:0000377
xref_analog: IMR:0100319
xref_analog: IMR:0100320
xref_analog: PubMed:10857556
xref_analog: PubMed:12040185
xref_analog: PubMed:15504351
is_a: IEV:0000446 ! Phosphorylation of STAT by JAK_p in cytosol
relationship: part_of IEV:0002259 ! IL6 signaling pathway (JAK1, JAK2, STAT3)
relationship: part_of IEV:0002262 ! LIF signaling pathway

[Term]
id: IEV:0002131
name: Phosphorylation of STAT5 by JAK1_p and JAK3_p in cytosol
xref_analog: IMR:0100319
xref_analog: IMR:0100321
xref_analog: IMR:0100733
xref_analog: PubMed:111278301
is_a: IEV:0000446 ! Phosphorylation of STAT by JAK_p in cytosol
relationship: part_of IEV:0000136 ! IL2 signaling (JAK1, JAK3, STAT5)

[Term]
id: IEV:0002132
name: Phosphorylation of STAT4 by JAK2_p and TYK2_p in cytosol
xref_analog: IMR:0000378
xref_analog: IMR:0100320
xref_analog: IMR:0100322
xref_analog: PubMed:10415122
xref_analog: PubMed:12805384
is_a: IEV:0000446 ! Phosphorylation of STAT by JAK_p in cytosol
relationship: part_of IEV:0000138 ! IL12 signaling pathway (JAK2, TYK2, STAT4)
relationship: part_of IEV:0003595 ! IL23 signaling pathway (JAK2, TYK2, STAT3, STAT4)

[Term]
id: IEV:0002133
name: Binding of GAF and GAS element in inner space of nucleus
exact_synonym: "Binding of STAT1 homodimer and GAS element" []
xref_analog: IGS:0000018
xref_analog: IMR:0000375
xref_analog: PubMed:12040185
is_a: IEV:0002100 ! Binding of STAT dimer and GAS in inner space of nucleus
relationship: part_of IEV:0000867 ! EPO signaling pathway
relationship: part_of IEV:0002260 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1)
relationship: part_of IEV:0002264 ! IFN gamma signaling pathway (JAK1, JAK2, STAT1)
relationship: part_of IEV:0003620 ! IL5 signaling pathway (JAK1, JAK2, STAT1, STAT5)

[Term]
id: IEV:0002134
name: Binding of STAT3 homodimer and GAS element in inner space of nucleus
xref_analog: IGS:0000018
xref_analog: IMR:0000377
xref_analog: PubMed:10857556
xref_analog: PubMed:12040185
is_a: IEV:0002100 ! Binding of STAT dimer and GAS in inner space of nucleus
relationship: part_of IEV:0000139 ! IL10 signaling (JAK1, TYK2, STAT3)
relationship: part_of IEV:0000867 ! EPO signaling pathway
relationship: part_of IEV:0001233 ! TPO signaling pathway (JAK2, STAT3)
relationship: part_of IEV:0002259 ! IL6 signaling pathway (JAK1, JAK2, STAT3)
relationship: part_of IEV:0002262 ! LIF signaling pathway
relationship: part_of IEV:0002265 ! IFN alpha signaling pathway (JAK1, TYK2, STAT3)

[Term]
id: IEV:0002135
name: Binding of STAT3 homodimer and SIE element in inner space of nucleus
xref_analog: IGS:0000019
xref_analog: IMR:0000377
xref_analog: PubMed:10857556
xref_analog: PubMed:12040185
is_a: IEV:0000049 ! Binding of STAT dimer and responsive element in inner space of nucleus
relationship: part_of IEV:0000139 ! IL10 signaling (JAK1, TYK2, STAT3)
relationship: part_of IEV:0000867 ! EPO signaling pathway
relationship: part_of IEV:0001233 ! TPO signaling pathway (JAK2, STAT3)
relationship: part_of IEV:0002259 ! IL6 signaling pathway (JAK1, JAK2, STAT3)
relationship: part_of IEV:0002262 ! LIF signaling pathway
relationship: part_of IEV:0002265 ! IFN alpha signaling pathway (JAK1, TYK2, STAT3)

[Term]
id: IEV:0002136
name: Binding of STAT1:STAT3 heterodimer and responsive element in inner space of nucleus
xref_analog: IGS:0000028
xref_analog: IMR:0000375
xref_analog: IMR:0000377
xref_analog: PubMed:15561601
is_a: IEV:0000049 ! Binding of STAT dimer and responsive element in inner space of nucleus
relationship: part_of IEV:0002261 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT3)

[Term]
id: IEV:0002137
name: Binding of STAT5 homodimer and GAS element in inner space of nucleus
xref_analog: IGS:0000018
xref_analog: IMR:0100733
xref_analog: PubMed:15561601
is_a: IEV:0002100 ! Binding of STAT dimer and GAS in inner space of nucleus
relationship: part_of IEV:0000135 ! IL3 signaling pathway (JAK1, JAK2, STAT5)
relationship: part_of IEV:0000136 ! IL2 signaling (JAK1, JAK3, STAT5)
relationship: part_of IEV:0000867 ! EPO signaling pathway
relationship: part_of IEV:0003620 ! IL5 signaling pathway (JAK1, JAK2, STAT1, STAT5)

[Term]
id: IEV:0002138
name: Binding of ISGF3 and ISRE in inner space of nucleus
exact_synonym: "Binding of STAT1:STAT2:IRF9 and ISRE" []
xref_analog: IGS:0000021
xref_analog: IMR:0001422
xref_analog: PubMed:12040185
is_a: IEV:0000049 ! Binding of STAT dimer and responsive element in inner space of nucleus
relationship: part_of IEV:0002263 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT2)

[Term]
id: IEV:0002139
name: Binding of STAT4 homodimer and GAS element in inner space of nucleus
xref_analog: IGS:0000018
xref_analog: IMR:0000378
xref_analog: PubMed:15004198
xref_analog: PubMed:9144409
is_a: IEV:0002100 ! Binding of STAT dimer and GAS in inner space of nucleus
relationship: part_of IEV:0000138 ! IL12 signaling pathway (JAK2, TYK2, STAT4)

[Term]
id: IEV:0002140
name: Phosphorylation of IFN alpha receptor by JAK1 and TYK2 in cytosol
xref_analog: IMR:0000135
xref_analog: IMR:0100319
xref_analog: IMR:0100322
xref_analog: PubMed:12040185
xref_analog: PubMed:15561601
xref_analog: PubMed:9287210
is_a: IEV:0000053 ! Phosphorylation of cytokine receptor by Jak in cytosol
relationship: part_of IEV:0002260 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1)
relationship: part_of IEV:0002261 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT3)
relationship: part_of IEV:0002263 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT2)
relationship: part_of IEV:0002265 ! IFN alpha signaling pathway (JAK1, TYK2, STAT3)

[Term]
id: IEV:0002141
name: Phosphorylation of IFN gamma receptor by JAK1 and JAK2 in cytosol
xref_analog: IMR:0000136
xref_analog: IMR:0100319
xref_analog: IMR:0100320
xref_analog: PubMed:12040185
is_a: IEV:0000053 ! Phosphorylation of cytokine receptor by Jak in cytosol
relationship: part_of IEV:0002264 ! IFN gamma signaling pathway (JAK1, JAK2, STAT1)

[Term]
id: IEV:0002142
name: Phosphorylation of IL-6 receptor by JAK1 and JAK2 in cytosol
xref_analog: IMR:0000104
xref_analog: IMR:0100319
xref_analog: IMR:0100320
xref_analog: PubMed:15504351
is_a: IEV:0000053 ! Phosphorylation of cytokine receptor by Jak in cytosol
relationship: part_of IEV:0002259 ! IL6 signaling pathway (JAK1, JAK2, STAT3)

[Term]
id: IEV:0002143
name: Phosphorylation of IL-10 receptor by JAK1 and TYK2 in cytosol
xref_analog: IMR:0000608
xref_analog: IMR:0100319
xref_analog: IMR:0100322
xref_analog: PubMed:12626585
is_a: IEV:0000053 ! Phosphorylation of cytokine receptor by Jak in cytosol
relationship: part_of IEV:0000139 ! IL10 signaling (JAK1, TYK2, STAT3)

[Term]
id: IEV:0002144
name: Phosphorylation of IL-2 receptor by JAK1 and JAK3 in cytosol
xref_analog: IMR:0000097
xref_analog: IMR:0100319
xref_analog: IMR:0100321
xref_analog: PubMed:10920190
xref_analog: PubMed:11160217
is_a: IEV:0000053 ! Phosphorylation of cytokine receptor by Jak in cytosol
relationship: part_of IEV:0000136 ! IL2 signaling (JAK1, JAK3, STAT5)

[Term]
id: IEV:0002145
name: Phosphorylation of IL-12 receptor by JAK2 and TYK2 in cytosol
xref_analog: IMR:0000602
xref_analog: IMR:0100320
xref_analog: IMR:0100322
xref_analog: PubMed:10415122
xref_analog: PubMed:12805384
is_a: IEV:0000053 ! Phosphorylation of cytokine receptor by Jak in cytosol
relationship: part_of IEV:0000138 ! IL12 signaling pathway (JAK2, TYK2, STAT4)

[Term]
id: IEV:0002146
name: Binding of IFN alpha receptor and JAK1 and TYK2 in cytosol
xref_analog: IMR:0000135
xref_analog: IMR:0100319
xref_analog: IMR:0100322
xref_analog: PubMed:12040185
is_a: IEV:0000051 ! Binding of cytokine receptor and JAK in cytosol
relationship: part_of IEV:0002260 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1)
relationship: part_of IEV:0002261 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT3)
relationship: part_of IEV:0002263 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT2)
relationship: part_of IEV:0002265 ! IFN alpha signaling pathway (JAK1, TYK2, STAT3)

[Term]
id: IEV:0002147
name: Binding of IFN gamma receptor and JAK1 and JAK2 in cytosol
xref_analog: IMR:0000136
xref_analog: IMR:0100319
xref_analog: IMR:0100320
xref_analog: PubMed:12040185
is_a: IEV:0000051 ! Binding of cytokine receptor and JAK in cytosol
relationship: part_of IEV:0002264 ! IFN gamma signaling pathway (JAK1, JAK2, STAT1)

[Term]
id: IEV:0002148
name: Binding of IL-6 receptor and JAK1 and JAK2 in cytosol
xref_analog: IMR:0000104
xref_analog: IMR:0100319
xref_analog: IMR:0100320
xref_analog: PubMed:12040185
is_a: IEV:0000051 ! Binding of cytokine receptor and JAK in cytosol
relationship: part_of IEV:0002259 ! IL6 signaling pathway (JAK1, JAK2, STAT3)

[Term]
id: IEV:0002149
name: Binding of IL-10 receptor and JAK1 and TYK2 in cytosol
xref_analog: IMR:0000608
xref_analog: IMR:0100319
xref_analog: IMR:0100322
xref_analog: PubMed:12626585
is_a: IEV:0000051 ! Binding of cytokine receptor and JAK in cytosol
relationship: part_of IEV:0000139 ! IL10 signaling (JAK1, TYK2, STAT3)

[Term]
id: IEV:0002150
name: Binding of IL-2 receptor and JAK1 and JAK3 in cytosol
xref_analog: IMR:0000097
xref_analog: IMR:0100319
xref_analog: IMR:0100321
xref_analog: PubMed:10920190
xref_analog: PubMed:8700888
is_a: IEV:0000051 ! Binding of cytokine receptor and JAK in cytosol
relationship: part_of IEV:0000136 ! IL2 signaling (JAK1, JAK3, STAT5)

[Term]
id: IEV:0002151
name: Binding of IL-12 receptor and JAK2 and TYK2 in cytosol
xref_analog: IMR:0000602
xref_analog: IMR:0100320
xref_analog: IMR:0100322
xref_analog: PubMed:12805384
is_a: IEV:0000051 ! Binding of cytokine receptor and JAK in cytosol
relationship: part_of IEV:0000138 ! IL12 signaling pathway (JAK2, TYK2, STAT4)

[Term]
id: IEV:0002152
name: Binding of IFN alpha and IFN alpha receptor and conformational change of receptors in plasma membrane
xref_analog: IMR:0000135
xref_analog: IMR:0100386
xref_analog: PubMed:12040185
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors in plasma membrane
relationship: part_of IEV:0002260 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1)
relationship: part_of IEV:0002261 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT3)
relationship: part_of IEV:0002263 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT2)
relationship: part_of IEV:0002265 ! IFN alpha signaling pathway (JAK1, TYK2, STAT3)

[Term]
id: IEV:0002153
name: Binding of IFN gamma and IFN gamma receptor and conformational change of receptors in plasma membrane
xref_analog: IMR:0000136
xref_analog: IMR:0100390
xref_analog: PubMed:12040185
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors in plasma membrane
relationship: part_of IEV:0002264 ! IFN gamma signaling pathway (JAK1, JAK2, STAT1)

[Term]
id: IEV:0002154
name: Binding of IL-6 and IL-6 receptor and conformational change of receptors in plasma membrane
xref_analog: IMR:0000010
xref_analog: IMR:0000104
xref_analog: PubMed:12040185
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors in plasma membrane
relationship: part_of IEV:0002259 ! IL6 signaling pathway (JAK1, JAK2, STAT3)

[Term]
id: IEV:0002155
name: Binding of LIF receptor and STAT3 in cytosol
xref_analog: IMR:0000130
xref_analog: IMR:0000377
xref_analog: PubMed:10857556
is_a: IEV:0000046 ! Binding of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0002262 ! LIF signaling pathway

[Term]
id: IEV:0002156
name: Phosphorylation of LIF receptor by JAK1 and JAK2 in cytosol
xref_analog: IMR:0000130
xref_analog: IMR:0100319
xref_analog: IMR:0100320
xref_analog: PubMed:10857556
xref_analog: PubMed:12040185
is_a: IEV:0000053 ! Phosphorylation of cytokine receptor by Jak in cytosol
relationship: part_of IEV:0002262 ! LIF signaling pathway

[Term]
id: IEV:0002157
name: Binding of LIF receptor and JAK1 and JAK2 in cytosol
xref_analog: IMR:0000130
xref_analog: IMR:0100319
xref_analog: IMR:0100320
xref_analog: PubMed:10586060
xref_analog: PubMed:10857556
is_a: IEV:0000051 ! Binding of cytokine receptor and JAK in cytosol
relationship: part_of IEV:0002262 ! LIF signaling pathway

[Term]
id: IEV:0002158
name: Autophosphorylation of TYK2 in cytosol
xref_analog: IMR:0100322
xref_analog: PubMed:10433356
xref_analog: PubMed:12040185
xref_analog: PubMed:12626585
xref_analog: PubMed:15561601
xref_analog: PubMed:9287210
is_a: IEV:0000052 ! Autophosphorylation of Jak in cytosol

[Term]
id: IEV:0002159
name: Autophosphorylation of JAK2 in cytosol
def: "The process of introducing a phosphoric group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GO:0042977]
xref_analog: IMR:0100320
xref_analog: PubMed:10857556
xref_analog: PubMed:12040185
xref_analog: PubMed:15561601
xref_analog: PubMed:9287210
xref_analog: PubMed:9351438
is_a: IEV:0000052 ! Autophosphorylation of Jak in cytosol
relationship: part_of IEV:0001233 ! TPO signaling pathway (JAK2, STAT3)

[Term]
id: IEV:0002160
name: Autophosphorylation of JAK1 in cytosol
xref_analog: IMR:0100319
xref_analog: PubMed:10433356
xref_analog: PubMed:10857556
xref_analog: PubMed:10920190
xref_analog: PubMed:12039028
xref_analog: PubMed:12040185
xref_analog: PubMed:15561601
xref_analog: PubMed:9287210
xref_analog: PubMed:9351438
is_a: IEV:0000052 ! Autophosphorylation of Jak in cytosol

[Term]
id: IEV:0002161
name: Autophosphorylation of JAK3 in cytosol
xref_analog: IMR:0100321
xref_analog: PubMed:10920190
xref_analog: PubMed:11160217
xref_analog: PubMed:12039028
xref_analog: PubMed:9287210
is_a: IEV:0000052 ! Autophosphorylation of Jak in cytosol

[Term]
id: IEV:0002162
name: Dissociation of IFN alpha receptor and STAT1 in cytosol
xref_analog: IMR:0000135
xref_analog: IMR:0000375
xref_analog: PubMed:15561601
is_a: IEV:0002096 ! Dissociation of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0002260 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1)
relationship: part_of IEV:0002261 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT3)

[Term]
id: IEV:0002163
name: Dissociation of IFN alpha receptor and STAT3 in cytosol
xref_analog: IMR:0000135
xref_analog: IMR:0000377
xref_analog: PubMed:15561601
is_a: IEV:0002096 ! Dissociation of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0002261 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT3)
relationship: part_of IEV:0002265 ! IFN alpha signaling pathway (JAK1, TYK2, STAT3)

[Term]
id: IEV:0002164
name: Dissociation of IFN gamma receptor and STAT1 in cytosol
xref_analog: IMR:0000136
xref_analog: IMR:0000375
xref_analog: PubMed:12040185
is_a: IEV:0002096 ! Dissociation of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0002264 ! IFN gamma signaling pathway (JAK1, JAK2, STAT1)

[Term]
id: IEV:0002165
name: Dissociation of IL-6 receptor and STAT3 in cytosol
xref_analog: IMR:0000104
xref_analog: IMR:0000377
xref_analog: PubMed:15504351
is_a: IEV:0002096 ! Dissociation of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0002259 ! IL6 signaling pathway (JAK1, JAK2, STAT3)

[Term]
id: IEV:0002166
name: Dissociation of IL-10 receptor and STAT3 in cytosol
xref_analog: IMR:0000377
xref_analog: IMR:0000608
xref_analog: PubMed:15561601
is_a: IEV:0002096 ! Dissociation of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0000139 ! IL10 signaling (JAK1, TYK2, STAT3)

[Term]
id: IEV:0002167
name: Dissociation of IL-2 receptor and STAT5 in cytosol
xref_analog: IMR:0000097
xref_analog: IMR:0100733
xref_analog: PubMed:11160217
xref_analog: PubMed:12039028
is_a: IEV:0002096 ! Dissociation of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0000136 ! IL2 signaling (JAK1, JAK3, STAT5)

[Term]
id: IEV:0002168
name: Dissociation of IL-12 receptor and STAT4 in cytosol
xref_analog: IMR:0000378
xref_analog: IMR:0000602
xref_analog: PubMed:12039028
xref_analog: PubMed:12040185
xref_analog: PubMed:15004198
is_a: IEV:0002096 ! Dissociation of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0000138 ! IL12 signaling pathway (JAK2, TYK2, STAT4)

[Term]
id: IEV:0002169
name: Binding of STAT1 and STAT2_p in cytosol
xref_analog: IMR:0000375
xref_analog: IMR:0000376
xref_analog: PubMed:12040185
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002263 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT2)

[Term]
id: IEV:0002170
name: Binding of STAT1:STAT2 heterodimer and IRF9 in cytosol
xref_analog: IMR:0000375
xref_analog: IMR:0000376
xref_analog: IMR:0000395
xref_analog: PubMed:11932384
xref_analog: PubMed:12040185
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002263 ! IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT2)

[Term]
id: IEV:0002171
name: Binding of LIF and LIF receptor and conformational change of receptors in plasma membrane
xref_analog: IMR:0000019
xref_analog: IMR:0000130
xref_analog: PubMed:10857556
xref_analog: PubMed:12487370
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors in plasma membrane
relationship: part_of IEV:0002262 ! LIF signaling pathway

[Term]
id: IEV:0002172
name: Binding of BMP2 and BMP receptor I/II in extracellular
xref_analog: IMR:0000702
xref_analog: IMR:0001424
xref_analog: IMR:0001425
is_a: IEV:0003573 ! Binding of BMP and BMP receptor I/II in extracellular

[Term]
id: IEV:0002173
name: Nuclear import of Smad1:Smad4
xref_analog: IMR:0100310
xref_analog: IMR:0100315
is_a: IEV:0000158 ! Nuclear import of R-Smad:Smad4

[Term]
id: IEV:0002174
name: Complex formation of Smad1 and Smad4 in cytosol
xref_analog: IMR:0100310
xref_analog: IMR:0100315
is_a: IEV:0000159 ! Complex formation of R-Smad and Smad4 in cytosol

[Term]
id: IEV:0002175
name: Binding of STAT3:p300:Smad1:Smad4 complex and GFAP promoter in inner space of nucleus
xref_analog: IMR:0000377
xref_analog: IMR:0001405
xref_analog: IMR:0100310
xref_analog: IMR:0100315
xref_analog: UniProt:P14136
is_a: IEV:0000156 ! Binding of R-Smad:Smad4 complex, Coactivator and responsive element in inner space of nucleus

[Term]
id: IEV:0002176
name: Dissociation of LIF receptor and STAT3 in cytosol
xref_analog: IMR:0000130
xref_analog: IMR:0000377
xref_analog: PubMed:10857556
is_a: IEV:0002096 ! Dissociation of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0002262 ! LIF signaling pathway

[Term]
id: IEV:0002177
name: Phosphorylation of BMPR1 by BMPR2 in cytosol
xref_analog: IMR:0000702
xref_analog: IMR:0001425
is_a: IEV:0003583 ! Phosphorylation of TGF beta superfamily receptor I by TGF beta superfamily receptor II in cytosol
relationship: part_of IEV:0000863 ! BMP signaling pathway
relationship: part_of IEV:0002337 ! BMP2 signaling pathway(through Smad)
relationship: part_of IEV:0002338 ! BMP2 signaling pathway(through TAK1)

[Term]
id: IEV:0002178
name: Binding of STAT3 and p300 and Smad1 in inner space of nucleus
xref_analog: IMR:0000377
xref_analog: IMR:0001405
xref_analog: IMR:0100310
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000044 ! JAK STAT pathway
relationship: part_of IEV:0002337 ! BMP2 signaling pathway(through Smad)

[Term]
id: IEV:0002179
name: Translocation of TRAF6 to cytosol
xref_analog: IMR:0100427
is_a: IEV:0000508 ! Translocation from plasma membrane to cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0002180
name: TGF beta receptor complex degradation signaling
xref_analog: PubMed:11278251
relationship: part_of IEV:0000905 ! Negative feedback regulation pathway of TGF beta superfamily signaling by (TGF receptor degradation by smurf)

[Term]
id: IEV:0002181
name: Complex formation of Smad7 and smurf1 in cytosol
xref_analog: IMR:0100318
xref_analog: IMR:0100513
xref_analog: PubMed:11278251
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002180 ! TGF beta receptor complex degradation signaling

[Term]
id: IEV:0002182
name: Binding of Smad7:smurf1 and TGF beta receptor complex in cytosol
xref_analog: IMR:0000092
xref_analog: IMR:0100318
xref_analog: IMR:0100513
xref_analog: PubMed:11278251
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002180 ! TGF beta receptor complex degradation signaling

[Term]
id: IEV:0002183
name: Proteasome degradation of TGF beta receptor complex by 26S proteasome in plasma membrane
xref_analog: IMR:0000092
xref_analog: IMR:0000310
xref_analog: PubMed:11278251
is_a: IEV:0000206 ! Proteasome degradation in plasma membrane
relationship: part_of IEV:0002180 ! TGF beta receptor complex degradation signaling

[Term]
id: IEV:0002184
name: Dissociation of Smad7:smurf1 and TGF beta receptor complex_Ub in cytosol
xref_analog: IMR:0000092
xref_analog: IMR:0100318
xref_analog: IMR:0100513
xref_analog: PubMed:11278251
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0002180 ! TGF beta receptor complex degradation signaling

[Term]
id: IEV:0002185
name: Ubiquitination of TGF beta receptor complex by smurf1 in cytosol
xref_analog: IMR:0000092
xref_analog: IMR:0100513
xref_analog: PubMed:11278251
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0002180 ! TGF beta receptor complex degradation signaling

[Term]
id: IEV:0002186
name: Negative regulation of (transcription by R-Smad:Smad4) in TGF beta super family signaling pathway
xref_analog: IMR:0000371
xref_analog: IMR:0100315
is_a: IEV:0000880 ! Negative regulation of TGF beta super family signaling pathway

[Term]
id: IEV:0002187
name: Binding of R-Smad:Smad4 complex, Corepressor, HDAC and responsive element in inner space of nucleus
xref_analog: IGS:0000028
xref_analog: IMR:0000371
xref_analog: IMR:0000427
xref_analog: IMR:0001166
xref_analog: IMR:0100315
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0002186 ! Negative regulation of (transcription by R-Smad:Smad4) in TGF beta super family signaling pathway

[Term]
id: IEV:0002188
name: SnoN degradation signaling
xref_analog: PubMed:11389444
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
is_a: IEV:0002190 ! Positive regulation of (transcription by R-Smad:Smad4 ) in TGF beta super family signaling pathway

[Term]
id: IEV:0002189
name: Binding of Smad2, smurf2 and SnoN
xref_analog: IMR:0002129
xref_analog: IMR:0100311
xref_analog: IMR:0100514
xref_analog: PubMed:11389444
is_a: IEV:0000186 ! Binding in unidentified cellular location
relationship: part_of IEV:0002188 ! SnoN degradation signaling

[Term]
id: IEV:0002190
name: Positive regulation of (transcription by R-Smad:Smad4 ) in TGF beta super family signaling pathway
xref_analog: IMR:0000371
xref_analog: IMR:0100315
is_a: IEV:0000881 ! Positive regulation of TGF beta super family signaling pathway

[Term]
id: IEV:0002191
name: Ubiquitination of SnoN by smurf2
xref_analog: IMR:0002129
xref_analog: IMR:0100514
xref_analog: PubMed:11389444
is_a: IEV:0000204 ! Ubiquitination in unidentified cellular location
relationship: part_of IEV:0002188 ! SnoN degradation signaling

[Term]
id: IEV:0002192
name: Proteasome degradation of SnoN_ub by 26S proteasome
xref_analog: IMR:0000310
xref_analog: IMR:0002129
xref_analog: PubMed:11389444
is_a: IEV:0000039 ! Proteasome degradation in unidentified cellular location
relationship: part_of IEV:0002188 ! SnoN degradation signaling

[Term]
id: IEV:0002193
name: Phosphorylation of Smad1 by MAPK in cytosol
xref_analog: IMR:0000224
xref_analog: IMR:0100310
xref_analog: PubMed:11752591
is_a: IEV:0000888 ! Phosphorylation of R-Smad:Smad4 by MAPK in cytosol

[Term]
id: IEV:0002194
name: Binding of LAT and Grb2 in cytosol
xref_analog: IMR:0000340
xref_analog: IMR:0000348
xref_analog: PubMed:15220003
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)

[Term]
id: IEV:0002195
name: Binding of RasGRP and DAG in cytosol
xref_analog: IMR:0100027
xref_analog: IMR:0100349
xref_analog: PubMed:15221855
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002199 ! Raf activation signaling (through RasGRP)

[Term]
id: IEV:0002196
name: Regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
exact_synonym: "Regulation of CD4 T cell receptor signaling pathway (through Ras Vav, Rac and JNK cascade)" []
is_a: IEV:0001374 ! Regulation of T cell receptor signaling pathway
relationship: regulates IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0002198
name: Negative regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
exact_synonym: "Negative regulation of CD4 T cell receptor signaling pathway (through Ras Vav, Rac and JNK cascade)" []
is_a: IEV:0001375 ! Negative regulation of T cell receptor signaling pathway
is_a: IEV:0002196 ! Regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
relationship: negatively_regulates IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0002199
name: Raf activation signaling (through RasGRP)
is_a: IEV:0002072 ! Raf activation signaling
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)

[Term]
id: IEV:0002200
name: GDP-GTP exchange of Ras by RasGRP in cytosol
xref_analog: IMR:0000290
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: IMR:0100349
xref_analog: PubMed:15221855
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0002199 ! Raf activation signaling (through RasGRP)

[Term]
id: IEV:0002201
name: Positive regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
exact_synonym: "Positive regulation of CD4 T cell receptor signaling pathway (through Ras Vav, Rac and JNK cascade)" []
is_a: IEV:0001376 ! Positive regulation of T cell receptor signaling pathway
is_a: IEV:0002196 ! Regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
relationship: positively_regulates IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0002202
name: Activation of PKC theta by Rac in cytosol
xref_analog: IMR:0000297
xref_analog: IMR:0100484
xref_analog: PubMed:11094261
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0001391 ! PKC theta activation signaling

[Term]
id: IEV:0002203
name: Phosphorylation of MKK4(SEK1) by PKC theta in cytosol
xref_analog: IMR:0100454
xref_analog: IMR:0100484
xref_analog: PubMed:11094621
is_a: IEV:0000227 ! Phosphorylation of MKK4/7 by MAPKKK in cytosol

[Term]
id: IEV:0002204
name: Phosphorylation of JNK by MKK4(SEK1)_p in cytosol
xref_analog: IMR:0000225
xref_analog: IMR:0100454
xref_analog: PubMed:11094261
is_a: IEV:0000228 ! Phosphorylation of JNK by MKK4/7_p in cytosol

[Term]
id: IEV:0002205
name: Nuclear transport of AP-1
xref_analog: IMR:0000414
xref_analog: PubMed:7546397
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0002206
name: Gene expression of IL2 by AP-1
xref_analog: IMR:0000008
xref_analog: IMR:0000414
xref_analog: PubMed:7546397
is_a: IEV:0000225 ! Gene expression of cytokine by AP-1
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0002207
name: Nuclear export of mRNA (IL2)
xref_analog: IMR:0000008
is_a: IEV:0002210 ! Nuclear export of mRNA (cytokine)
relationship: part_of IEV:0002206 ! Gene expression of IL2 by AP-1

[Term]
id: IEV:0002208
name: Transcription of IL2 by AP-1 in nucleus
xref_analog: IMR:0000008
xref_analog: IMR:0000414
xref_analog: PubMed:7546397
is_a: IEV:0002099 ! Transcription of cytokine by AP-1 in nucleus
relationship: part_of IEV:0002206 ! Gene expression of IL2 by AP-1

[Term]
id: IEV:0002209
name: Translation of IL2 in cytosol
xref_analog: IMR:0000008
xref_analog: PubMed:7546397
is_a: IEV:0002211 ! Translation of cytokine in cytosol
relationship: part_of IEV:0002206 ! Gene expression of IL2 by AP-1

[Term]
id: IEV:0002210
name: Nuclear export of mRNA (cytokine)
xref_analog: IMR:0000006
is_a: IEV:0000909 ! Nuclear export of mRNA
relationship: part_of IEV:0000225 ! Gene expression of cytokine by AP-1

[Term]
id: IEV:0002211
name: Translation of cytokine in cytosol
xref_analog: IMR:0000006
is_a: IEV:0003550 ! Translation in cytosol
relationship: part_of IEV:0000225 ! Gene expression of cytokine by AP-1

[Term]
id: IEV:0002212
name: Chilling temperature treatment
is_a: IEV:0000378 ! Low temperature treatment

[Term]
id: IEV:0002213
name: Thermoperiodism
is_a: IEV:0000371 ! Temperature treatment

[Term]
id: IEV:0002214
name: Cell division within the secondary xylem
relationship: part_of IEV:0001339 ! Wood development

[Term]
id: IEV:0002215
name: Cell division within the vascular cambium
relationship: part_of IEV:0001339 ! Wood development

[Term]
id: IEV:0002216
name: Cell wall organization and biosynthesis
relationship: part_of IEV:0001339 ! Wood development

[Term]
id: IEV:0002217
name: Cellulose biosynthesis
def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GO:0030244]
exact_synonym: "cellulose anabolism" []
exact_synonym: "cellulose biosynthetic process" []
exact_synonym: "cellulose formation" []
exact_synonym: "cellulose synthesis" []
xref_analog: GO:0030244
relationship: part_of IEV:0002216 ! Cell wall organization and biosynthesis

[Term]
id: IEV:0002218
name: Hemicellulose biosynthesis
relationship: part_of IEV:0002216 ! Cell wall organization and biosynthesis

[Term]
id: IEV:0002219
name: Cytokine receptor degradation signaling
xref_analog: PubMed:15541651
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
relationship: part_of IEV:0002223 ! Negative feedback regulation of JAK STAT pathway by (cytokine receptor degradation signaling)

[Term]
id: IEV:0002220
name: Ubiquitination of cytokine receptor by SOCS3 in cytosol
xref_analog: IMR:0000095
xref_analog: IMR:0100839
xref_analog: PubMed:15541651
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0002219 ! Cytokine receptor degradation signaling

[Term]
id: IEV:0002221
name: Binding of SOCS3 and cytokine receptor in cytosol
xref_analog: IMR:0000095
xref_analog: IMR:0100839
xref_analog: PubMed:14607831
xref_analog: PubMed:15541651
is_a: IEV:0000152 ! Binding of SOCS and Cytokine receptor in cytosol
relationship: part_of IEV:0002219 ! Cytokine receptor degradation signaling

[Term]
id: IEV:0002222
name: Proteasome degradation of cytokine receptor by 26S proteasome in cytosol
xref_analog: IMR:0000095
xref_analog: IMR:0000310
xref_analog: PubMed:15541651
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0002219 ! Cytokine receptor degradation signaling

[Term]
id: IEV:0002223
name: Negative feedback regulation of JAK STAT pathway by (cytokine receptor degradation signaling)
is_a: IEV:0002228 ! Negative feedback regulation of JAK STAT pathway

[Term]
id: IEV:0002224
name: Gene expression of SOCS3 by STAT dimer
xref_analog: IMR:0000374
xref_analog: IMR:0100839
is_a: IEV:0002101 ! Gene expression of SOCS by STAT dimer

[Term]
id: IEV:0002225
name: Transcription of SOCS3 by STAT dimer in nucleus
xref_analog: IMR:0000374
xref_analog: IMR:0100839
xref_analog: PubMed:14607831
is_a: IEV:0002103 ! Transcription of SOCS by STAT dimer in nucleus
relationship: part_of IEV:0002224 ! Gene expression of SOCS3 by STAT dimer

[Term]
id: IEV:0002226
name: Nuclear export of mRNA (SOCS3)
xref_analog: IMR:0100839
xref_analog: PubMed:14607831
is_a: IEV:0002105 ! Nuclear export of mRNA (SOCS)
relationship: part_of IEV:0002224 ! Gene expression of SOCS3 by STAT dimer

[Term]
id: IEV:0002227
name: Translation of SOCS3 in cytosol
xref_analog: IMR:0100839
xref_analog: PubMed:14607831
is_a: IEV:0002104 ! Translation of SOCS in cytosol
relationship: part_of IEV:0002224 ! Gene expression of SOCS3 by STAT dimer

[Term]
id: IEV:0002228
name: Negative feedback regulation of JAK STAT pathway
is_a: IEV:0000150 ! Negative regulation of JAK STAT pathway

[Term]
id: IEV:0002229
name: Negative feedback regulation of JAK STAT pathway by (JAK degradation signaling)
is_a: IEV:0002228 ! Negative feedback regulation of JAK STAT pathway

[Term]
id: IEV:0002230
name: JAK degradation signaling
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
relationship: part_of IEV:0002229 ! Negative feedback regulation of JAK STAT pathway by (JAK degradation signaling)

[Term]
id: IEV:0002231
name: Binding of SOCS1 and JAK in cytosol
xref_analog: IMR:0000213
xref_analog: IMR:0100837
is_a: IEV:0000132 ! Binding of SOCS and JAK in cytosol
relationship: part_of IEV:0002230 ! JAK degradation signaling

[Term]
id: IEV:0002232
name: Ubiquitination of JAK by SOCS1
xref_analog: IMR:0000213
xref_analog: IMR:0100837
relationship: part_of IEV:0002230 ! JAK degradation signaling

[Term]
id: IEV:0002233
name: Proteasome degradation of JAK by 26S proteasome
xref_analog: IMR:0000213
xref_analog: IMR:0000310
relationship: part_of IEV:0002230 ! JAK degradation signaling

[Term]
id: IEV:0002238
name: Gene expression of SOCS1 by STAT dimer
xref_analog: IMR:0000374
xref_analog: IMR:0100837
xref_analog: PubMed:14607831
is_a: IEV:0002101 ! Gene expression of SOCS by STAT dimer
relationship: part_of IEV:0002229 ! Negative feedback regulation of JAK STAT pathway by (JAK degradation signaling)

[Term]
id: IEV:0002239
name: Nuclear export of mRNA (SOCS1)
xref_analog: IMR:0100837
xref_analog: PubMed:14607831
is_a: IEV:0002105 ! Nuclear export of mRNA (SOCS)
relationship: part_of IEV:0002238 ! Gene expression of SOCS1 by STAT dimer

[Term]
id: IEV:0002240
name: Transcription of SOCS1 by STAT dimer in nucleus
xref_analog: IMR:0000374
xref_analog: IMR:0100837
xref_analog: PubMed:14607831
is_a: IEV:0002103 ! Transcription of SOCS by STAT dimer in nucleus
relationship: part_of IEV:0002238 ! Gene expression of SOCS1 by STAT dimer

[Term]
id: IEV:0002241
name: Translation of SOCS1 in cytosol
xref_analog: IMR:0100837
xref_analog: PubMed:14607831
is_a: IEV:0002104 ! Translation of SOCS in cytosol
relationship: part_of IEV:0002238 ! Gene expression of SOCS1 by STAT dimer

[Term]
id: IEV:0002242
name: Dephosphorylation of JAK by SHP-1 in cytosol
xref_analog: IMR:0000213
xref_analog: IMR:0000275
xref_analog: PubMed:14607831
is_a: IEV:0000146 ! Dephosphorylation of Jak by PTP in cytosol

[Term]
id: IEV:0002243
name: Dephosphorylation of cytokine receptor by SHP-1 in cytosol
xref_analog: IMR:0000095
xref_analog: IMR:0000275
is_a: IEV:0000147 ! Dephosphorylation of cytokine receptor by PTP in cytosol

[Term]
id: IEV:0002244
name: Dephosphorylation of STAT5 by SHP-1 in cytosol
xref_analog: IMR:0000275
xref_analog: IMR:0100733
xref_analog: PubMed:10617656
is_a: IEV:0000149 ! Dephosphorylation of STAT dimer by PTP in cytosol

[Term]
id: IEV:0002245
name: Negative regulation of (Dimerization of STAT) in JAK STAT pathway
xref_analog: IMR:0000374
xref_analog: PubMed:10617656
is_a: IEV:0000150 ! Negative regulation of JAK STAT pathway

[Term]
id: IEV:0002246
name: Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway
xref_analog: IMR:0000374
xref_analog: IMR:0000460
is_a: IEV:0000551 ! Positive regulation of JAK STAT pathway

[Term]
id: IEV:0002247
name: Phosphorylation of STAT dimer by serine kinase in cytosol and/or nucleus
xref_analog: IMR:0000223
xref_analog: IMR:0000374
xref_analog: PubMed:9153303
is_a: IEV:0001735 ! Phosphorylation in cytosol and/or nucleus
relationship: part_of IEV:0002246 ! Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway

[Term]
id: IEV:0002248
name: Regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)
exact_synonym: "Regulation of CD4 T cell receptor signaling pathway (through Ras and Erk cascade)" []
is_a: IEV:0001374 ! Regulation of T cell receptor signaling pathway
relationship: regulates IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)

[Term]
id: IEV:0002249
name: Negative regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)
exact_synonym: "Negative regulation of CD4 T cell receptor signaling pathway (through Ras and Erk cascade)" []
is_a: IEV:0001375 ! Negative regulation of T cell receptor signaling pathway
is_a: IEV:0002248 ! Regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)
relationship: negatively_regulates IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)

[Term]
id: IEV:0002250
name: Positive regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)
exact_synonym: "Positive regulation of CD4 T cell receptor signaling pathway (through Ras and Erk cascade)" []
is_a: IEV:0001376 ! Positive regulation of T cell receptor signaling pathway
is_a: IEV:0002248 ! Regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)
relationship: positively_regulates IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)

[Term]
id: IEV:0002251
name: Negative regulation of (Phosphorylation of ZAP-70 by Lck_PY)
xref_analog: IMR:0000221
xref_analog: IMR:0100353
is_a: IEV:0000512 ! Negative regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0002198 ! Negative regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
is_a: IEV:0002249 ! Negative regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)

[Term]
id: IEV:0002252
name: Negative regulation of (Phosphorylation of PIP2 by PI3K)
xref_analog: IMR:0000265
xref_analog: IMR:0001350
is_a: IEV:0000512 ! Negative regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0002198 ! Negative regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
is_a: IEV:0002249 ! Negative regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)

[Term]
id: IEV:0002253
name: Negative regulation of (Phosphorylation of LAT by ZAP-70)
xref_analog: IMR:0000221
is_a: IEV:0000512 ! Negative regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0002198 ! Negative regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
is_a: IEV:0002249 ! Negative regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)

[Term]
id: IEV:0002254
name: Negative regulation of (Phosphorylation of Vav by ZAP-70)
xref_analog: IMR:0000221
is_a: IEV:0000512 ! Negative regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0002198 ! Negative regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
is_a: IEV:0002249 ! Negative regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)

[Term]
id: IEV:0002255
name: Negative regulation of (Lck activation signaling)
is_a: IEV:0000512 ! Negative regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0002198 ! Negative regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
is_a: IEV:0002249 ! Negative regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)

[Term]
id: IEV:0002256
name: Negative regulation of (Fyn activation signaling)
is_a: IEV:0000512 ! Negative regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0002198 ! Negative regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
is_a: IEV:0002249 ! Negative regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)

[Term]
id: IEV:0002257
name: Negative regulation of (Phosphorylation of Vav by Syk)
xref_analog: IMR:0000222
is_a: IEV:0000512 ! Negative regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0002198 ! Negative regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)
is_a: IEV:0002249 ! Negative regulation of CD4 T cell receptor signaling (through Ras and Erk cascade)

[Term]
id: IEV:0002258
name: Actin filament reorganization during cell cycle
def: "Rearrangement of the spatial distribution of actin filaments and associated proteins that accompanies progression of the cell cycle." [GO:0030037]
xref_analog: GO:0030037
xref_analog: PubMed:15313367
is_a: IEV:0001324 ! Actin filament organization

[Term]
id: IEV:0002259
name: IL6 signaling pathway (JAK1, JAK2, STAT3)
xref_analog: PubMed:12773095
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0002260
name: IFN alpha signaling pathway (JAK1, TYK2, STAT1)
xref_analog: PubMed:15561601
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0002261
name: IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT3)
xref_analog: PubMed:15561601
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0002262
name: LIF signaling pathway
def: "The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands." [GO:0048861]
exact_synonym: "leukemia inhibitory factor signaling pathway" []
xref_analog: GO:0048861
xref_analog: PubMed:10857556
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0002263
name: IFN alpha signaling pathway (JAK1, TYK2, STAT1, STAT2)
xref_analog: PubMed:12041185
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0002264
name: IFN gamma signaling pathway (JAK1, JAK2, STAT1)
xref_analog: PubMed:12040185
is_a: IEV:0000044 ! JAK STAT pathway
relationship: part_of IEV:0003874 ! Th1 cell proliferation

[Term]
id: IEV:0002265
name: IFN alpha signaling pathway (JAK1, TYK2, STAT3)
xref_analog: PubMed:15561601
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0002266
name: TGF beta super family signaling pathway (through JNK cascade)
xref_analog: PubMed:15733830
is_a: IEV:0000090 ! TGF beta super family signaling pathway
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0002267
name: Wnt signaling pathway (Xenopus)
def: "OBSOLETE: remap to 'Wnt signaling pathway' IEV:0000027." [XX:<new dbxref>]
xref_analog: PubMed:15473860
is_obsolete: true

[Term]
id: IEV:0002268
name: Wnt signaling pathway (Mammalia)
def: "OBSOLETE: remap to 'Wnt signaling pathway' IEV:0000027." [XX:<new dbxref>]
xref_analog: PubMed:15473860
is_obsolete: true

[Term]
id: IEV:0002269
name: Wnt signaling pathway (Drosophila)
def: "OBSOLETE: remap to 'Wnt signaling pathway' IEV:0000027." [XX:<new dbxref>]
xref_analog: PubMed:15473860
is_obsolete: true

[Term]
id: IEV:0002270
name: C. elegans endoderm induction Wnt signaling pathway
def: "OBSOLETE: remap to 'Endoderm induction Wnt signaling pathway' IEV:0003455." [XX:<new dbxref>]
xref_analog: PubMed:12210516
is_obsolete: true

[Term]
id: IEV:0002271
name: Phosphorylation of STAT1 by JAK1_p and JAK2_p in cytosol
xref_analog: IMR:0000375
xref_analog: IMR:0100319
xref_analog: IMR:0100320
xref_analog: PubMed:12040185
is_a: IEV:0000446 ! Phosphorylation of STAT by JAK_p in cytosol
relationship: part_of IEV:0002264 ! IFN gamma signaling pathway (JAK1, JAK2, STAT1)

[Term]
id: IEV:0002272
name: Binding of beta-catenin, TCF and Smad4 in inner space of nucleus
xref_analog: IMR:0000177
xref_analog: IMR:0000418
xref_analog: IMR:0100315
xref_analog: PubMed:10693808
xref_analog: PubMed:10890911
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0002273
name: Dissociation of Groucho and TCF in inner space of nucleus
xref_analog: IMR:0000418
xref_analog: IMR:0100748
xref_analog: PubMed:15473860
is_a: IEV:0001046 ! Dissociation in inner space of nucleus
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0002274
name: Binding of beta-catenin:TCF:Smad4 and responsive element in inner space of nucleus
xref_analog: IGS:0000028
xref_analog: IMR:0000177
xref_analog: IMR:0000418
xref_analog: IMR:0100315
xref_analog: PubMed:10693808
xref_analog: PubMed:10890911
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0002275
name: Transcription of Xtwn gene in nucleus
xref_analog: IMR:0001829
xref_analog: PubMed:10693808
xref_analog: PubMed:10890911
is_a: IEV:0002284 ! Transcription by beta-catenin:TCF complex and Smad4 in nucleus

[Term]
id: IEV:0002276
name: Transcription of Siamois gene in nucleus
xref_analog: IMR:0001830
xref_analog: PubMed:15473860
is_a: IEV:0002282 ! Transcription by beta-catenin:TCF complex in nucleus

[Term]
id: IEV:0002278
name: Binding of Wnt and HSPG in extracellular
xref_analog: IMR:0000003
xref_analog: IMR:0001125
xref_analog: PubMed:15473860
xref_analog: PubMed:2158444
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0002279
name: Binding of wingless and Dally in extracellular
xref_analog: IMR:0002958
xref_analog: IMR:0100761
xref_analog: PubMed:10421371
xref_analog: PubMed:10978892
xref_analog: PubMed:15473860
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0002278 ! Binding of Wnt and HSPG in extracellular

[Term]
id: IEV:0002280
name: Gene expression by beta-catenin:TCF complex
alt_id: IEV:0002277
exact_synonym: "Gene expression by beta-catenin TCF complex" []
exact_synonym: "Gene expression in response to beta-catenin TCF complex" []
xref_analog: IMR:0000177
xref_analog: IMR:0000418
is_a: IEV:0000233 ! Gene expression by transcriptional regulator
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0002282
name: Transcription by beta-catenin:TCF complex in nucleus
alt_id: IEV:0000037
exact_synonym: "Transcription in response to beta-catenin TCF complex" []
exact_synonym: "Transcription in response to beta-catenin TCF complex (Xenopus laevis)" []
narrow_synonym: "Transcription by beta-catenin TCF complex (C. elegans)" []
narrow_synonym: "Transcription by beta-catenin TCF complex (Drosophila)" []
narrow_synonym: "Transcription by beta-catenin TCF complex (Mammals)" []
narrow_synonym: "Transcription by beta-catenin TCF complex (Xenopus)" []
xref_analog: IMR:0000177
xref_analog: IMR:0000418
xref_analog: PubMed:15473860
is_a: IEV:0003549 ! Transcription in nucleus
relationship: part_of IEV:0002280 ! Gene expression by beta-catenin:TCF complex

[Term]
id: IEV:0002283
name: Gene expression by beta-catenin:TCF complex and Smad4
xref_analog: IMR:0000177
xref_analog: IMR:0000418
xref_analog: IMR:0100315
is_a: IEV:0000233 ! Gene expression by transcriptional regulator
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0002284
name: Transcription by beta-catenin:TCF complex and Smad4 in nucleus
narrow_synonym: "Transcription by beta-catenin TCF complex and Smad4 (Mammals)" []
narrow_synonym: "Transcription by beta-catenin TCF complex and Smad4 (Xenopus)" []
xref_analog: IMR:0000177
xref_analog: IMR:0000418
xref_analog: IMR:0100315
is_a: IEV:0003549 ! Transcription in nucleus
relationship: part_of IEV:0002283 ! Gene expression by beta-catenin:TCF complex and Smad4

[Term]
id: IEV:0002285
name: Transcription by beta-catenin TCF complex and Smad4 (Xenopus)
def: "OBSOLETE: remap to 'Transcription by beta-catenin TCF complex and Smad4' IEV:0002284." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002286
name: Transcription by beta-catenin TCF complex (Mammals)
def: "OBSOLETE: remap to 'Transcription by beta-catenin TCF complex' IEV:0002282." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002287
name: Transcription by beta-catenin TCF complex (Drosophila)
def: "OBSOLETE: remap to 'Transcription by beta-catenin TCF complex' IEV:0002282." [XX:<new dbxref>]
xref_analog: PubMed:15473860
is_obsolete: true

[Term]
id: IEV:0002288
name: Transcription by beta-catenin TCF complex and Smad4 (Mammals)
def: "OBSOLETE: remap to 'Transcription by beta-catenin TCF complex and Smad4' IEV:0002284." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002289
name: Transcription by beta-catenin TCF complex (Xenopus)
def: "OBSOLETE: remap to 'Transcription by beta-catenin TCF complex' IEV:0002282." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002290
name: Regulation of B cell receptor signaling (through IKK-NF-kappaB cascade)
exact_synonym: "Regulation of B cell receptor signaling pathway (through IKK-NF-kappaB cascade)" []
is_a: IEV:0001273 ! Regulation of B cell receptor signaling
relationship: regulates IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0002291
name: Negative regulation of B cell receptor signaling (through IKK-NF-kappaB cascade)
is_a: IEV:0001274 ! Negative regulation of B cell receptor signaling
is_a: IEV:0002290 ! Regulation of B cell receptor signaling (through IKK-NF-kappaB cascade)
relationship: negatively_regulates IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0002292
name: Positive regulation of B cell receptor signaling (through IKK-NF-kappaB cascade)
exact_synonym: "Positive regulation of B cell receptor signaling pathway (through IKK-NF-kappaB cascade)" []
is_a: IEV:0001275 ! Positive regulation of B cell receptor signaling
is_a: IEV:0002290 ! Regulation of B cell receptor signaling (through IKK-NF-kappaB cascade)
relationship: positively_regulates IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0002293
name: Binding of IL-4 receptor and JAK1 and JAK3 in cytosol
xref_analog: IMR:0000107
xref_analog: IMR:0100319
xref_analog: IMR:0100321
is_a: IEV:0000051 ! Binding of cytokine receptor and JAK in cytosol
relationship: part_of IEV:0000134 ! IL4 signaling pathway (JAK1, JAK3, STAT6)

[Term]
id: IEV:0002294
name: Phosphorylation of IL-4 receptor by JAK1 and JAK3 in cytosol
xref_analog: IMR:0000107
xref_analog: IMR:0100319
xref_analog: IMR:0100321
is_a: IEV:0000053 ! Phosphorylation of cytokine receptor by Jak in cytosol
relationship: part_of IEV:0000134 ! IL4 signaling pathway (JAK1, JAK3, STAT6)

[Term]
id: IEV:0002295
name: Binding of IL-4 receptor and STAT6 in cytosol
xref_analog: IMR:0000107
xref_analog: IMR:0000381
is_a: IEV:0000046 ! Binding of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0000134 ! IL4 signaling pathway (JAK1, JAK3, STAT6)
relationship: part_of IEV:0003609 ! IL13 signaling pathway (JAK1, TYK2, STAT6)

[Term]
id: IEV:0002296
name: Phosphorylation of STAT6 by JAK1_p and JAK3_p in cytosol
xref_analog: IMR:0000381
xref_analog: IMR:0100319
xref_analog: IMR:0100321
is_a: IEV:0000446 ! Phosphorylation of STAT by JAK_p in cytosol
relationship: part_of IEV:0000134 ! IL4 signaling pathway (JAK1, JAK3, STAT6)

[Term]
id: IEV:0002297
name: Dissociation of IL-4 receptor and STAT6 in cytosol
xref_analog: IMR:0000107
xref_analog: IMR:0000381
is_a: IEV:0002096 ! Dissociation of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0000134 ! IL4 signaling pathway (JAK1, JAK3, STAT6)
relationship: part_of IEV:0003609 ! IL13 signaling pathway (JAK1, TYK2, STAT6)

[Term]
id: IEV:0002298
name: Dimerization of STAT6 in cytosol
xref_analog: IMR:0000381
is_a: IEV:0000047 ! Dimerization of STAT in cytosol
relationship: part_of IEV:0000134 ! IL4 signaling pathway (JAK1, JAK3, STAT6)
relationship: part_of IEV:0003609 ! IL13 signaling pathway (JAK1, TYK2, STAT6)

[Term]
id: IEV:0002299
name: Nuclear import of STAT6 homodimer
xref_analog: IMR:0000381
is_a: IEV:0000048 ! Nuclear import of STAT dimer
relationship: part_of IEV:0000134 ! IL4 signaling pathway (JAK1, JAK3, STAT6)
relationship: part_of IEV:0003609 ! IL13 signaling pathway (JAK1, TYK2, STAT6)

[Term]
id: IEV:0002300
name: Binding of STAT6 homodimer and promoter in inner space of nucleus
xref_analog: IGS:0000029
xref_analog: IMR:0000381
is_a: IEV:0000049 ! Binding of STAT dimer and responsive element in inner space of nucleus
relationship: part_of IEV:0000134 ! IL4 signaling pathway (JAK1, JAK3, STAT6)
relationship: part_of IEV:0003609 ! IL13 signaling pathway (JAK1, TYK2, STAT6)

[Term]
id: IEV:0002301
name: Dephosphorylation of STAT6 by SHP-1 in cytosol
xref_analog: IMR:0000275
xref_analog: IMR:0000381
is_a: IEV:0000149 ! Dephosphorylation of STAT dimer by PTP in cytosol

[Term]
id: IEV:0002302
name: Syk activation signaling
xref_analog: PubMed:12461567
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0002303
name: Lyn activation signaling
xref_analog: PubMed:12461567
is_a: IEV:0001589 ! Src family activation signaling
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0002304
name: Phosphorylation of Ig alpha by Lyn in cytosol
xref_analog: IMR:0000211
xref_analog: IMR:0100541
xref_analog: PubMed:12461567
is_a: IEV:0001279 ! Phosphorylation of Ig alpha:beta by non-receptor tyrosine kinase in cytosol

[Term]
id: IEV:0002305
name: Phosphorylation of Ig beta by Lyn in cytosol
xref_analog: IMR:0000211
xref_analog: IMR:0100542
xref_analog: PubMed:12461567
is_a: IEV:0001279 ! Phosphorylation of Ig alpha:beta by non-receptor tyrosine kinase in cytosol

[Term]
id: IEV:0002306
name: Binding of Ig beta and Syk in cytosol
xref_analog: IMR:0000222
xref_analog: IMR:0100542
xref_analog: ISBN:081533642X
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0002307
name: Phosphorylation of BLNK by Syk in cytosol
xref_analog: IMR:0000222
xref_analog: IMR:0000353
xref_analog: PubMed:152119998
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0002308
name: Phosphorylation of PLC gamma2 by Syk in cytosol
xref_analog: IMR:0000222
xref_analog: IMR:0000733
xref_analog: PubMed:12461567
is_a: IEV:0000530 ! Phosphorylation of PLC gamma by Syk in cytosol

[Term]
id: IEV:0002309
name: Phosphorylation of PLC gamma2 by Btk in cytosol
xref_analog: IMR:0000215
xref_analog: IMR:0000733
xref_analog: PubMed:12461567
is_a: IEV:0001290 ! Phosphorylation of PLC gamma by Btk in cytosol

[Term]
id: IEV:0002310
name: Binding of BLNK, BTK, PLC gamma2, Vav and PIP3 in cytosol
xref_analog: IMR:0000215
xref_analog: IMR:0000353
xref_analog: IMR:0000434
xref_analog: IMR:0000733
xref_analog: IMR:0001352
xref_analog: PubMed:12461567
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0002311
name: Binding of BLNK and PLC gamma2 in cytosol
xref_analog: IMR:0000353
xref_analog: IMR:0000733
xref_analog: PubMed:12461567
is_a: IEV:0001286 ! Binding of BLNK and PLC gamma in cytosol
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0002310 ! Binding of BLNK, BTK, PLC gamma2, Vav and PIP3 in cytosol

[Term]
id: IEV:0002312
name: Binding of PLC gamma2, BAM32 and PIP3 in cytosol
xref_analog: IMR:0000733
xref_analog: IMR:0001352
xref_analog: IMR:0002136
xref_analog: PubMed:12461567
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0002313
name: Binding of Btk and PIP3 in cytosol
xref_analog: IMR:0000215
xref_analog: IMR:0001352
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002310 ! Binding of BLNK, BTK, PLC gamma2, Vav and PIP3 in cytosol

[Term]
id: IEV:0002314
name: Binding of BAM32 and PIP3 in cytosol
xref_analog: IMR:0001352
xref_analog: IMR:0002136
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0002315
name: Binding of PLC gamma2 and PIP3 in cytosol
xref_analog: IMR:0000733
xref_analog: IMR:0001352
is_a: IEV:0000469 ! Binding of PLC gamma and PIP3 in cytosol
relationship: part_of IEV:0002310 ! Binding of BLNK, BTK, PLC gamma2, Vav and PIP3 in cytosol

[Term]
id: IEV:0002316
name: Binding of CD19 and PI3K in cytosol
xref_analog: IMR:0000265
xref_analog: IMR:0001964
xref_analog: PubMed:12461567
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0002317
name: Activation of IKK complex by PKCs in cytosol
xref_analog: IMR:0000243
xref_analog: IMR:0000245
xref_analog: PubMed:12461567
is_a: IEV:0000020 ! Activation in cytosol
is_a: IEV:0001379 ! IKK activation signaling

[Term]
id: IEV:0002318
name: Activation of IKK complex by PKC beta in cytosol
xref_analog: IMR:0000243
xref_analog: IMR:0001146
xref_analog: PubMed:12461567
is_a: IEV:0002317 ! Activation of IKK complex by PKCs in cytosol

[Term]
id: IEV:0002319
name: Binding of GH receptor and JAK2 in cytosol
xref_analog: IMR:0100320
xref_analog: IMR:0100735
is_a: IEV:0000051 ! Binding of cytokine receptor and JAK in cytosol
relationship: part_of IEV:0000133 ! Growth hormone signaling pathway (JAK2, STAT5)

[Term]
id: IEV:0002320
name: Phosphorylation of GH receptor by JAK2 in cytosol
xref_analog: IMR:0100320
xref_analog: IMR:0100735
is_a: IEV:0000053 ! Phosphorylation of cytokine receptor by Jak in cytosol
relationship: part_of IEV:0000133 ! Growth hormone signaling pathway (JAK2, STAT5)

[Term]
id: IEV:0002321
name: Binding of GH receptor and STAT5 in cytosol
xref_analog: IMR:0100733
xref_analog: IMR:0100735
is_a: IEV:0000046 ! Binding of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0000133 ! Growth hormone signaling pathway (JAK2, STAT5)

[Term]
id: IEV:0002322
name: Phosphorylation of STAT5 by JAK2_p in cytosol
xref_analog: IMR:0100320
xref_analog: IMR:0100733
is_a: IEV:0000446 ! Phosphorylation of STAT by JAK_p in cytosol
relationship: part_of IEV:0000133 ! Growth hormone signaling pathway (JAK2, STAT5)
relationship: part_of IEV:0000135 ! IL3 signaling pathway (JAK1, JAK2, STAT5)
relationship: part_of IEV:0000867 ! EPO signaling pathway
relationship: part_of IEV:0003620 ! IL5 signaling pathway (JAK1, JAK2, STAT1, STAT5)

[Term]
id: IEV:0002323
name: Dissociation of GH receptor and STAT5 in cytosol
xref_analog: IMR:0100733
xref_analog: IMR:0100735
is_a: IEV:0002096 ! Dissociation of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0000133 ! Growth hormone signaling pathway (JAK2, STAT5)

[Term]
id: IEV:0002324
name: Binding of GH and GH receptor and conformational change of receptors in plasma membrane
xref_analog: IMR:0100102
xref_analog: IMR:0100735
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors in plasma membrane
relationship: part_of IEV:0000133 ! Growth hormone signaling pathway (JAK2, STAT5)

[Term]
id: IEV:0002325
name: Dephosphorylation of GHR_p by SHP-2 in cytosol
xref_analog: IMR:0000276
xref_analog: IMR:0100735
is_a: IEV:0000147 ! Dephosphorylation of cytokine receptor by PTP in cytosol
is_a: IEV:0001750 ! Negative regulation of Growth hormone signaling pathway (JAK2 STAT5)

[Term]
id: IEV:0002326
name: Binding of IL3 receptor and JAK2 in cytosol
xref_analog: IMR:0000109
xref_analog: IMR:0100320
is_a: IEV:0000051 ! Binding of cytokine receptor and JAK in cytosol
relationship: part_of IEV:0000135 ! IL3 signaling pathway (JAK1, JAK2, STAT5)

[Term]
id: IEV:0002327
name: Phosphorylation of IL-3 receptor by JAK2 in cytosol
xref_analog: IMR:0000109
xref_analog: IMR:0100320
is_a: IEV:0000053 ! Phosphorylation of cytokine receptor by Jak in cytosol
relationship: part_of IEV:0000135 ! IL3 signaling pathway (JAK1, JAK2, STAT5)

[Term]
id: IEV:0002328
name: Binding of IL-3 receptor and STAT5 in cytosol
xref_analog: IMR:0000109
xref_analog: IMR:0100733
is_a: IEV:0000046 ! Binding of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0000135 ! IL3 signaling pathway (JAK1, JAK2, STAT5)

[Term]
id: IEV:0002329
name: Dissociation of IL-3 receptor and STAT5 in cytosol
xref_analog: IMR:0000109
xref_analog: IMR:0100733
is_a: IEV:0002096 ! Dissociation of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0000135 ! IL3 signaling pathway (JAK1, JAK2, STAT5)

[Term]
id: IEV:0002330
name: Binding of IL-7 receptor and JAK1 and JAK3 in cytosol
xref_analog: IMR:0000111
xref_analog: IMR:0100319
xref_analog: IMR:0100321
is_a: IEV:0000051 ! Binding of cytokine receptor and JAK in cytosol
relationship: part_of IEV:0000140 ! IL7 signaling (JAK1, JAK3, STAT5)

[Term]
id: IEV:0002331
name: Phosphorylation of IL-7 receptor by JAK1 and JAK3 in cytosol
xref_analog: IMR:0000111
xref_analog: IMR:0100319
xref_analog: IMR:0100321
is_a: IEV:0000053 ! Phosphorylation of cytokine receptor by Jak in cytosol
relationship: part_of IEV:0000140 ! IL7 signaling (JAK1, JAK3, STAT5)

[Term]
id: IEV:0002332
name: Binding of IL-7 receptor and STAT5 in cytosol
xref_analog: IMR:0000111
xref_analog: IMR:0100733
is_a: IEV:0000046 ! Binding of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0000140 ! IL7 signaling (JAK1, JAK3, STAT5)

[Term]
id: IEV:0002333
name: Dissociation of IL-7 receptor and STAT5 in cytosol
xref_analog: IMR:0000111
xref_analog: IMR:0100733
is_a: IEV:0002096 ! Dissociation of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0000140 ! IL7 signaling (JAK1, JAK3, STAT5)

[Term]
id: IEV:0002334
name: Binding of IL-7 and IL-7 receptor and conformational change of receptors in plasma membrane
alt_id: IEV:0001346
def: "Combining with interleukin-7 to initiate a change in cell activity." [XX:<new dbxref>]
exact_synonym: "Binding of IL7 and IL7 receptor and conformational change of receptors in plasma membrane" []
xref_analog: GO:0005139
xref_analog: GO:0019982
xref_analog: IMR:0000111
xref_analog: IMR:0000586
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors in plasma membrane
relationship: part_of IEV:0000140 ! IL7 signaling (JAK1, JAK3, STAT5)

[Term]
id: IEV:0002335
name: Binding of IL-7 R and PI3K in cytosol
xref_analog: IMR:0000111
xref_analog: IMR:0000265
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000140 ! IL7 signaling (JAK1, JAK3, STAT5)

[Term]
id: IEV:0002336
name: Phosphorylation of PI3K by JAK1_p in cytosol
xref_analog: IMR:0000265
xref_analog: IMR:0100319
is_a: IEV:0000025 ! Phosphorylation in cytosol

[Term]
id: IEV:0002337
name: BMP2 signaling pathway(through Smad)
is_a: IEV:0000863 ! BMP signaling pathway
relationship: part_of IEV:0002500 ! Ventral mesoderm specification

[Term]
id: IEV:0002338
name: BMP2 signaling pathway(through TAK1)
is_a: IEV:0000863 ! BMP signaling pathway

[Term]
id: IEV:0002339
name: TGF beta signaling pathway (through TAK1)
is_a: IEV:0000864 ! TGF beta signaling pathway

[Term]
id: IEV:0002340
name: Drosophila Toll-like receptor signaling
def: "OBSOLETE: remap to 'Toll receptor signaling' IEV:0003490." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002341
name: Binding of PGRP-SA and GNBP1 [Drosophila]
def: "OBSOLETE: remap to 'Binding of PGRP-SA and GNBP1' IEV:0003496." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002342
name: Binding of PGRP-SA:GNBP1 and PGN [Drosophila]
def: "OBSOLETE: remap to 'Binding of PGRP-SA:GNBP1 and PGN' IEV:0003497." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002343
name: Binding of PGRP-SD and PGN [Drosophila]
def: "OBSOLETE: remap to 'Binding of PGRP-SD and PGN' IEV:0003498." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002344
name: Binding of GNBP3 and beta1-3 glucan [Drosophila]
def: "OBSOLETE: remap to 'Binding of GNBP3 and beta1-3 glucan' IEV:0003494." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002345
name: Activation of serine protease [Drosophila]
def: "OBSOLETE: remap to 'Activation of serine protease' IEV:0003491." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002346
name: Activation of PSH by GNBP3 [Drosophila]
def: "OBSOLETE: remap to 'Activation of PSH by GNBP3' IEV:0003492." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002347
name: Activation of Spaetzle by serine protease [Drosophila]
def: "OBSOLETE: remap to 'Activation of Spaetzle by serine protease' IEV:0003504." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002348
name: Activation of Spaetzle by PSH [Drosophila]
def: "OBSOLETE: remap to 'Activation of Spaetzle by PSH' IEV:0003503." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002349
name: Binding of Toll and Spaetzle [Drosophila]
def: "OBSOLETE: remap to 'Binding of Toll and Spaetzle' IEV:0003500." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002350
name: Dimerization of Toll by Spaetzle [Drosophila]
def: "OBSOLETE: remap to 'Dimerization of Toll by Spaetzle' IEV:0003529." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002351
name: Binding of Toll and dMyD88:Tube [Drosophila]
def: "OBSOLETE: remap to 'Binding of Toll and MyD88:Tube' IEV:0003499." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002352
name: Binding of Toll:dMyD88:Tube and Pelle [Drosophila]
def: "OBSOLETE: remap to 'Binding of Toll:MyD88:Tube and Pelle' IEV:0003501." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002353
name: Autophosphorylation of Pelle [Drosophila]
def: "OBSOLETE: remap to 'Autophosphorylation of Pelle' IEV:0003493." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002354
name: Dissociation of Toll:dMyD88:Tube and Pelle [Drosophila]
def: "OBSOLETE: remap to 'Dissociation of Toll:MyD88:Tube and Pelle' IEV:0003530." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002355
name: Phosphorylation of dTRAF2 by Pelle_p [Drosophila]
def: "OBSOLETE: remap to 'Phosphorylation of TRAF2 by Pelle_p' IEV:0003540." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002356
name: Binding of dTRAF2 and Ref(2):DaPKC [Drosophila]
def: "OBSOLETE: remap to 'Binding of TRAF2 and Ref(2):DaPKC' IEV:0003495." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002357
name: Nuclear import of dTRAF2:Ref(2)P:DaPKC [Drosophila]
def: "OBSOLETE: remap to 'Nuclear import of TRAF2:Ref(2)P:DaPKC' IEV:0003539." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002358
name: Phosphorylation of Cactus [Drosophila]
def: "OBSOLETE: remap to 'Phosphorylation of Cactus' IEV:0003522." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002359
name: Dissociation of Cactus_p and DIF [Drosophila]
def: "OBSOLETE: remap to 'Dissociation of Cactus_p and DIF' IEV:0003510." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002360
name: Dissociation of Cactus_p and Dorsal:DIF [Drosophila]
def: "OBSOLETE: remap to 'Dissociation of Cactus_p and Dorsal:DIF' IEV:0003524." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002361
name: Nuclear import of DIF [Drosophila]
def: "OBSOLETE: remap to 'Nuclear import of DIF' IEV:0003521." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002362
name: Nuclear import of Dorsal [Drosophila]
def: "OBSOLETE: remap to 'Nuclear import of Dorsal' IEV:0003538." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002363
name: Nuclear import of Dorsal:DIF [Drosophila]
def: "OBSOLETE: remap to 'Nuclear import of Dorsal:DIF' IEV:0003528." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002364
name: Activation of DIF [Drosophila]
def: "OBSOLETE: remap to 'Activation of DIF' IEV:0003509." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002365
name: Activation of Dorsal [Drosophila]
def: "OBSOLETE: remap to 'Activation of Dorsal' IEV:0003531." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002366
name: Activation of DIF:Dorsal [Drosophila]
def: "OBSOLETE: remap to 'Activation of DIF:Dorsal' IEV:0003523." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002367
name: Binding of DIF and NF-kappaB binding sequence [Drosophila]
def: "OBSOLETE: remap to 'Binding of DIF and NF-kappaB binding sequence' IEV:0003512." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002368
name: Binding of Dorsal and NF-kappaB binding sequence [Drosophila]
def: "OBSOLETE: remap to 'Binding of Dorsal and NF-kappaB binding sequence' IEV:0003534." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002369
name: Binding of DIF:Dorsal and NF-kappaB binding sequence [Drosophila]
def: "OBSOLETE: remap to 'Binding of DIF:Dorsal and NF-kappaB binding sequence' IEV:0003526." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002370
name: Transcription of antimicrobial peptide by DIF [Drosophila]
def: "OBSOLETE: remap to 'Transcription of antimicrobial peptide by DIF' IEV:0003517." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002371
name: Transcription of antimicrobial peptide by Dorsal [Drosophila]
def: "OBSOLETE: remap to 'Transcription of antimicrobial peptide by Dorsal' IEV:0003537." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002372
name: Transcription of antimicrobial peptide by DIF:Dorsal [Drosophila]
def: "OBSOLETE: remap to 'Transcription of antimicrobial peptide by DIF:Dorsal' IEV:0003527." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002373
name: DIF signaling [Drosophila]
def: "OBSOLETE: remap to 'DIF signaling' IEV:0003506." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002374
name: Dorsal signaling [Drosophila]
def: "OBSOLETE: remap to 'Dorsal signaling' IEV:0003507." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002375
name: DIF:Dorsal signaling [Drosophila]
def: "OBSOLETE: remap to 'DIF:Dorsal signaling' IEV:0003508." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002376
name: Expression of antimicrobial peptide by Relish [Drosophila]
def: "OBSOLETE: remap to 'Expression of antimicrobial peptide by Relish' IEV:0003464." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002377
name: Expression of drosomycin by Relish [Drosophila]
def: "OBSOLETE: remap to 'Expression of drosomycin by Relish' IEV:0003475." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002378
name: Expression of cecropin by Relish [Drosophila]
def: "OBSOLETE: remap to 'Expression of cecropin by Relish' IEV:0002644." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002379
name: Expression of diptericin by Relish [Drosophila]
def: "OBSOLETE: remap to 'Expression of diptericin by Relish' IEV:0003472." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002380
name: Drosophila IMD pathway [Drosophila]
def: "OBSOLETE: remap to 'IMD signaling pathway' IEV:0003456." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002381
name: Binding of PGRP-LC and PGN [Drosophila]
def: "OBSOLETE: remap to 'Binding of PGRP-LC and PGN' IEV:0003465." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002382
name: Binding of PGRP-LC and LPS [Drosophila]
def: "OBSOLETE: remap to 'Binding of PGRP-LC and LPS' IEV:0003457." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002383
name: Binding of PGRP-LE and PGN [Drosophila]
def: "OBSOLETE: remap to 'Binding of PGRP-LE and PGN' IEV:0003466." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002384
name: Binding of PGRP-LC and IMD [Drosophila]
def: "OBSOLETE: remap to 'Binding of PGRP-LC and IMD' IEV:0003461." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002385
name: Binding of IMD and dFADD [Drosophila]
def: "OBSOLETE: remap to 'Binding of IMD and FADD' IEV:0003463." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002386
name: Binding of dFADD and Dredd [Drosophila]
def: "OBSOLETE: remap to 'Binding of FADD and caspase8' IEV:0003458." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002387
name: Binding of Dnr-1 and Dredd [Drosophila]
def: "OBSOLETE: remap to 'Binding of Dnr-1 and caspase8' IEV:0003462." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002388
name: Activation of TAK1 by IMD [Drosophila]
def: "OBSOLETE: remap to 'Activation of TAK1 by IMD' IEV:0003459." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002389
name: Phosphorylation of DmIKK by TAK1 [Drosophila]
def: "OBSOLETE: remap to 'Phosphorylation of IKK complex by TAK1' IEV:0000784." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002390
name: Phosphorylation of Relish by IKK [Drosophila]
def: "OBSOLETE: remap to 'Phosphorylation of Relish by IKK' IEV:0003469." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002391
name: Cleavage and activation of Relish by Dredd [Drosophila]
def: "OBSOLETE: remap to 'Cleavage and activation of Relish by caspase8' IEV:0003467." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002392
name: Nuclear import of Relish [Drosophila]
def: "OBSOLETE: remap to 'Nuclear import of Relish' IEV:0003471." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002393
name: Binding of Relish and NF-kappaB binding sequence [Drosophila]
def: "OBSOLETE: remap to 'Binding of Relish and NF-kappaB binding sequence' IEV:0003468." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002394
name: Transcription of antimicrobial peptide by Relish [Drosophila]
def: "OBSOLETE: remap to 'Transcription of antimicrobial peptide by Relish' IEV:0003478." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002395
name: Expression of drosocin by Relish [Drosophila]
def: "OBSOLETE: remap to 'Expression of drosocin by Relish' IEV:0003473." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002396
name: Expression of attacin by Relish [Drosophila]
def: "OBSOLETE: remap to 'Expression of attacin by Relish' IEV:0003474." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002397
name: Expression of defensin by DIF:Relish [Drosophila]
def: "OBSOLETE: remap to 'Expression of defensin by DIF:Relish' IEV:0003477." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002398
name: Dissociation of Cactus_p and Dorsal [Drosophila]
def: "OBSOLETE: remap to 'Dissociation of Cactus_p and Dorsal' IEV:0003532." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002399
name: Transacetylation
def: "Reaction, that can affect K,C,A,D,E,Q,G,I,K,M,P,S,T,Y,V residues." [MI:0192]
xref_analog: EC:2.3.1.12
xref_analog: EC:2.3.1.29
xref_analog: EC:2.3.1.4
xref_analog: EC:2.3.1.57
xref_analog: EC:2.3.1.87
xref_analog: EC:2.3.1.9
xref_analog: MI:0192
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0002400
name: Binding of Angiotensin II and AT1R in extracellular
xref_analog: IMR:0001721
xref_analog: IMR:0100150
is_a: IEV:0000662 ! Binding of GPCR ligand and GPCR in extracellular
relationship: part_of IEV:0002633 ! Heterotrimeric GPCR signaling pathway (through Angiotensin and G alpha q)

[Term]
id: IEV:0002401
name: Binding of AT1R and G alpha q in cytosol
xref_analog: IMR:0001721
xref_analog: IMR:0100378
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002633 ! Heterotrimeric GPCR signaling pathway (through Angiotensin and G alpha q)

[Term]
id: IEV:0002402
name: Dissociation of AT1R, G alpha s-GTP and G beta:G gamma in cytosol
xref_analog: IMR:0001354
xref_analog: IMR:0001721
xref_analog: IMR:0100018
xref_analog: IMR:0100366
is_a: IEV:0000721 ! Dissociation of G alpha s-GTP and G beta:G gamma in cytosol
relationship: part_of IEV:0002633 ! Heterotrimeric GPCR signaling pathway (through Angiotensin and G alpha q)

[Term]
id: IEV:0002403
name: Binding of G alpha q-GTP and PLC in cytosol
xref_analog: IMR:0000284
xref_analog: IMR:0001354
xref_analog: IMR:0100378
is_a: IEV:0002016 ! Binding of G alpha q-GTP and effector in cytosol

[Term]
id: IEV:0002404
name: Binding of Glutamate and Group I mGlu receptor in extracellular
xref_analog: IMR:0001729
xref_analog: IMR:0100119
is_a: IEV:0000662 ! Binding of GPCR ligand and GPCR in extracellular
relationship: part_of IEV:0002653 ! Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)

[Term]
id: IEV:0002405
name: Binding of Group I mGlu receptor and G alpha q in cytosol
xref_analog: IMR:0001729
xref_analog: IMR:0100378
is_a: IEV:0002064 ! Binding of GPCR and G alpha q in cytosol

[Term]
id: IEV:0002406
name: Dissociation of Group I mGlu receptor, G alpha q-GTP and G beta:G gamma in cytosol
xref_analog: IMR:0001354
xref_analog: IMR:0001729
xref_analog: IMR:0100018
xref_analog: IMR:0100378
is_a: IEV:0000749 ! Dissociation of G alpha q-GTP and G beta:G gamma in cytosol
relationship: part_of IEV:0002653 ! Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)

[Term]
id: IEV:0002407
name: Dissociation of NF-kappaB and I-kappaB [mammals]
def: "OBSOLETE: remap to 'Dissociation of NF-kappaB and I-kappaB' IEV:0000215." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002408
name: TNFR1 signaling pathway
xref_analog: REACT:1432.1
is_a: IEV:0000465 ! TNFR signaling pathway

[Term]
id: IEV:0002409
name: TNFR2 signaling pathway
is_a: IEV:0000465 ! TNFR signaling pathway

[Term]
id: IEV:0002410
name: Phosphorylation of I-kappaB_p by IKK complex_p [mammals]
def: "OBSOLETE: remap to 'Phosphorylation of I-kappaB_p by IKK complex_p in cytosol' IEV:0000213." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002411
name: Binding of TRAF6:TAK1:TAB1:TAB2 complex and ubiquitin ligase in cytosol
xref_analog: IMR:0000232
xref_analog: IMR:0000329
xref_analog: IMR:0000441
xref_analog: IMR:0000893
xref_analog: IMR:0100427
xref_analog: PubMed:12620219
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0002412
name: Phosphorylation of p38 by KDR_p in cytosol
xref_analog: IMR:0000066
xref_analog: IMR:0000226
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0002632 ! VEGF receptor signaling pathway

[Term]
id: IEV:0002413
name: Phosphorylation of MAPKAPK2/3 by p38_p in cytosol
xref_analog: IMR:0000226
xref_analog: IMR:0001689
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0002632 ! VEGF receptor signaling pathway

[Term]
id: IEV:0002414
name: Phosphorylation of HSP27 by MAPKAPK2/3_p in cytosol
xref_analog: IMR:0001689
xref_analog: IMR:0001692
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0002632 ! VEGF receptor signaling pathway

[Term]
id: IEV:0002415
name: Phosphorylation of Akt by protein kinase in cytosol
xref_analog: IMR:0000209
xref_analog: IMR:0000250
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001484 ! AKT(PKB) activation signaling

[Term]
id: IEV:0002416
name: Binding of Dopamine and D1-like receptor in extracellular
xref_analog: IMR:0001761
xref_analog: IMR:0100113
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0002637 ! Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)

[Term]
id: IEV:0002417
name: Binding of D1-like receptor and G alpha s in cytosol
xref_analog: IMR:0001761
xref_analog: IMR:0100366
is_a: IEV:0001984 ! Binding of GPCR and G alpha s in cytosol

[Term]
id: IEV:0002418
name: Dissociation of D1-like receptor, G alpha s-GTP and G beta:G gamma in cytosol
xref_analog: IMR:0001354
xref_analog: IMR:0001761
xref_analog: IMR:0100018
xref_analog: IMR:0100366
is_a: IEV:0000721 ! Dissociation of G alpha s-GTP and G beta:G gamma in cytosol
relationship: part_of IEV:0002637 ! Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)

[Term]
id: IEV:0002419
name: Binding of G alpha s-GTP and adenylate cyclase type V in cytosol
xref_analog: IMR:0000722
xref_analog: IMR:0001354
xref_analog: IMR:0100366
is_a: IEV:0000686 ! Binding of G alpha s-GTP and adenylate cyclase in cytosol

[Term]
id: IEV:0002420
name: Hydrolysis of ATP to cAMP by adenylate cyclase type V in cytosol
xref_analog: IMR:0000722
xref_analog: IMR:0001351
xref_analog: IMR:0100024
is_a: IEV:0000687 ! Hydrolysis of ATP to cAMP by adenylate cyclase in cytosol

[Term]
id: IEV:0002421
name: Phosphorylation of CREB by PKA in cytosol
xref_analog: IMR:0000249
xref_analog: IMR:0000420
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0002637 ! Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)

[Term]
id: IEV:0002422
name: Activation of PP2A by PKA in cytosol
xref_analog: IMR:0000249
xref_analog: IMR:0000280
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0002637 ! Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)

[Term]
id: IEV:0002423
name: Phosphorylation of DARPP-32 by PKA in cytosol
xref_analog: IMR:0000249
xref_analog: IMR:0001763
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0002637 ! Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)

[Term]
id: IEV:0002424
name: Dephosphorylation of NMDA glutamate receptor by PP1 in cytosol
xref_analog: IMR:0000083
xref_analog: IMR:0000279
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0002637 ! Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)

[Term]
id: IEV:0002425
name: Dephosphorylation of L-type Ca2+ channel_p by PP1 in cytosol
xref_analog: IMR:0000279
xref_analog: IMR:0000749
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0002637 ! Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)

[Term]
id: IEV:0002426
name: Phosphorylation of L-type Ca2+ channel by PKA in cytosol
xref_analog: IMR:0000249
xref_analog: IMR:0000749
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0002637 ! Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)

[Term]
id: IEV:0002427
name: Phosphorylation of NMDA glutamate receptor by PKA in cytosol
xref_analog: IMR:0000083
xref_analog: IMR:0000249
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0002637 ! Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)

[Term]
id: IEV:0002428
name: Phosphorylation of DARPP-32 by CDK5 in cytosol
xref_analog: IMR:0001763
xref_analog: IMR:0100601
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0002637 ! Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)

[Term]
id: IEV:0002429
name: Dephosphorylation of DARPP-32_p by PP2A in cytosol
xref_analog: IMR:0000280
xref_analog: IMR:0001763
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0002637 ! Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)

[Term]
id: IEV:0002430
name: Binding of TGF beta receptor I and XIAP in cytosol
xref_analog: IMR:0000710
xref_analog: IMR:0100331
xref_analog: PubMed:14687659
xref_analog: PubMed:15733830
is_a: IEV:0000013 ! Binding in cytosol

[Term]
id: IEV:0002431
name: Binding of XIAP and TAB1 in cytosol
xref_analog: IMR:0000441
xref_analog: IMR:0100331
xref_analog: PubMed:14687659
xref_analog: PubMed:15733830
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002339 ! TGF beta signaling pathway (through TAK1)

[Term]
id: IEV:0002432
name: Activation of TAK1 by TAB1 in cytosol
xref_analog: IMR:0000232
xref_analog: IMR:0000441
xref_analog: PubMed:14687659
xref_analog: PubMed:15733830
is_a: IEV:0000282 ! Activation of TAK1 in cytosol
relationship: part_of IEV:0002339 ! TGF beta signaling pathway (through TAK1)

[Term]
id: IEV:0002433
name: Phosphorylation of MKK4 by MEKK1 in cytosol
xref_analog: IMR:0100222
xref_analog: IMR:0100454
xref_analog: ISBN:4320055608
xref_analog: ISBN:4897060729
xref_analog: ISBN:4897065739
is_a: IEV:0000227 ! Phosphorylation of MKK4/7 by MAPKKK in cytosol
is_a: IEV:0003390 ! Phosphorylation of MKK by MEKK1 in cytosol

[Term]
id: IEV:0002434
name: Phosphorylation of JNK1 by MKK4_p in cytosol
xref_analog: IMR:0000683
xref_analog: IMR:0100454
xref_analog: ISBN:4320055608
xref_analog: ISBN:4897060729
xref_analog: ISBN:4897065739
is_a: IEV:0002204 ! Phosphorylation of JNK by MKK4(SEK1)_p in cytosol

[Term]
id: IEV:0002435
name: Nuclear import of JNK1_p
xref_analog: IMR:0000683
xref_analog: ISBN:4320055608
xref_analog: ISBN:4897060729
xref_analog: ISBN:4897065739
is_a: IEV:0000229 ! Nuclear import of JNK_p

[Term]
id: IEV:0002436
name: Phosphorylation of c-Jun by JNK1_p in inner space of nucleus
xref_analog: IMR:0000683
xref_analog: IMR:0000817
xref_analog: ISBN:4320055608
xref_analog: ISBN:4897060729
xref_analog: ISBN:4897065739
is_a: IEV:0000230 ! Phosphorylation of c-Jun by JNK_p in inner space of nucleus

[Term]
id: IEV:0002437
name: PKC delta activation signaling
is_a: IEV:0000779 ! PKC activation signaling

[Term]
id: IEV:0002438
name: Activation of PKC delta by DAG in cytosol
xref_analog: IMR:0001148
xref_analog: IMR:0100027
is_a: IEV:0002484 ! Activation of PKC by DAG in cytosol
relationship: part_of IEV:0000866 ! NGF receptor signaling pathway
relationship: part_of IEV:0002626 ! FGF receptor signaling pathway

[Term]
id: IEV:0002440
name: Binding of EGF and EGFR in extracellular
xref_analog: IMR:0000081
xref_analog: IMR:0100279
is_a: IEV:0000842 ! Binding of RTK-ligand and RTK in extracellular
relationship: part_of IEV:0000865 ! EGF receptor signaling pathway

[Term]
id: IEV:0002441
name: Dimerization of EGFR in plasma membrane
xref_analog: IMR:0000081
is_a: IEV:0000846 ! Dimerization of RTK in plasma membrane
relationship: part_of IEV:0000865 ! EGF receptor signaling pathway

[Term]
id: IEV:0002442
name: Autophosphorylation of EGFR in plasma membrane
xref_analog: IMR:0000081
is_a: IEV:0000843 ! Autophosphorylation of RTK in plasma membrane
relationship: part_of IEV:0000865 ! EGF receptor signaling pathway

[Term]
id: IEV:0002444
name: Phosphorylation of Shc by EGFR_p in cytosol
xref_analog: IMR:0000081
xref_analog: IMR:0000347
is_a: IEV:0002631 ! Phosphorylation of Shc by RTK in cytosol
relationship: part_of IEV:0000865 ! EGF receptor signaling pathway

[Term]
id: IEV:0002446
name: Binding of Sos and Ras in cytosol
xref_analog: IMR:0000290
xref_analog: IMR:0000435
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000602 ! Raf activation signaling (through Grb2 and Sos)
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0002447
name: Activation of Raf1 by Ras-GTP in cytosol
xref_analog: IMR:0000290
xref_analog: IMR:0001354
xref_analog: IMR:0100355
is_a: IEV:0000608 ! Activation of Raf by Ras-GTP in cytosol

[Term]
id: IEV:0002448
name: Activation of MEKK1 by Ras-GTP in cytosol
xref_analog: IMR:0000290
xref_analog: IMR:0001354
xref_analog: IMR:0100222
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000865 ! EGF receptor signaling pathway
relationship: part_of IEV:0001257 ! PDGF receptor signaling pathway

[Term]
id: IEV:0002449
name: Phosphorylation of MEK1/2(MKK1/2) by Raf1 in cytosol
xref_analog: IMR:0000261
xref_analog: IMR:0100355
is_a: IEV:0000820 ! Phosphorylation of MEK1/2(MKK1/2) by Raf in cytosol

[Term]
id: IEV:0002450
name: Phosphorylation of ERK1/2 by MEK1/2(MKK1/2)_p in cytosol
xref_analog: IMR:0000227
xref_analog: IMR:0000261
is_a: IEV:0000476 ! Phosphorylation of ERK by MEK1/2(MKK1/2)_p in cytosol

[Term]
id: IEV:0002451
name: Phosphorylation of Shc by PDGF Receptor_p in cytosol
xref_analog: IMR:0000068
xref_analog: IMR:0000347
is_a: IEV:0002631 ! Phosphorylation of Shc by RTK in cytosol
relationship: part_of IEV:0001257 ! PDGF receptor signaling pathway

[Term]
id: IEV:0002453
name: Binding of HGF and Met in extracellular
xref_analog: IMR:0000033
xref_analog: IMR:0000071
is_a: IEV:0000842 ! Binding of RTK-ligand and RTK in extracellular
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0002454
name: Dimerization of Met in plasma membrane
xref_analog: IMR:0000071
is_a: IEV:0000846 ! Dimerization of RTK in plasma membrane
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0002455
name: Autophosphorylation of Met in plasma membrane
xref_analog: IMR:0000071
is_a: IEV:0000843 ! Autophosphorylation of RTK in plasma membrane
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0002456
name: Binding of Met_p and Src in cytosol
xref_analog: IMR:0000071
xref_analog: IMR:0100575
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0002457
name: Binding of Met_p and Gab1 in cytosol
xref_analog: IMR:0000071
xref_analog: IMR:0001410
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0002458
name: Binding of Met_p and Grb2 in cytosol
alt_id: IEV:0002468
exact_synonym: "Binding of (HGF:Met_p) and (Grb2:Sos)" []
xref_analog: IMR:0000071
xref_analog: IMR:0000340
is_a: IEV:0000844 ! Binding of RTK and Grb2 in cytosol
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0002459
name: Binding of Gab1 and Grb2 in cytosol
xref_analog: IMR:0000340
xref_analog: IMR:0001410
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002626 ! FGF receptor signaling pathway
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0002460
name: Binding of Gab1 and PLC gamma in cytosol
xref_analog: IMR:0000285
xref_analog: IMR:0001410
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0002461
name: Binding of Gab1 and SHP-2 in cytosol
xref_analog: IMR:0000276
xref_analog: IMR:0001410
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0002463
name: Binding of Gab1 and Crk in cytosol
xref_analog: IMR:0000335
xref_analog: IMR:0001410
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0002464
name: Binding of Crk and Dock180 in cytosol
xref_analog: IMR:0000335
xref_analog: IMR:0001468
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0002465
name: Binding of Dock180 and Rac in cytosol
xref_analog: IMR:0000297
xref_analog: IMR:0001468
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0002466
name: Binding of C3G and Rap1 in cytosol
xref_analog: IMR:0000436
xref_analog: IMR:0001504
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0002469
name: Phosphorylation of Shc by Met_p in cytosol
xref_analog: IMR:0000071
xref_analog: IMR:0000347
is_a: IEV:0002631 ! Phosphorylation of Shc by RTK in cytosol
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0002470
name: Binding of NGF and TRK in extracellular
xref_analog: IMR:0000072
xref_analog: IMR:0100407
is_a: IEV:0000842 ! Binding of RTK-ligand and RTK in extracellular
relationship: part_of IEV:0000866 ! NGF receptor signaling pathway

[Term]
id: IEV:0002471
name: Dimerization of TRK in plasma membrane
xref_analog: IMR:0000072
is_a: IEV:0000846 ! Dimerization of RTK in plasma membrane
relationship: part_of IEV:0000866 ! NGF receptor signaling pathway

[Term]
id: IEV:0002472
name: Autophosphorylation of TRK in plasma membrane
xref_analog: IMR:0000072
is_a: IEV:0000843 ! Autophosphorylation of RTK in plasma membrane
relationship: part_of IEV:0000866 ! NGF receptor signaling pathway

[Term]
id: IEV:0002474
name: Phosphorylation of Shc by TRK_p in cytosol
xref_analog: IMR:0000072
xref_analog: IMR:0000347
is_a: IEV:0002631 ! Phosphorylation of Shc by RTK in cytosol
relationship: part_of IEV:0000866 ! NGF receptor signaling pathway

[Term]
id: IEV:0002476
name: Binding of TRK_p and PLC gamma in cytosol
xref_analog: IMR:0000072
xref_analog: IMR:0000285
is_a: IEV:0000283 ! Binding of RTK and PLC gamma in cytosol
relationship: part_of IEV:0000866 ! NGF receptor signaling pathway

[Term]
id: IEV:0002477
name: Phosphorylation of PLC gamma by TRK_p in cytosol
xref_analog: IMR:0000072
xref_analog: IMR:0000285
is_a: IEV:0003816 ! Phosphorylation of PLC gamma by receptor tyrosine kinase in cytosol
relationship: part_of IEV:0000866 ! NGF receptor signaling pathway

[Term]
id: IEV:0002478
name: Binding of VEGF and KDR in extracellular
xref_analog: IMR:0000031
xref_analog: IMR:0000066
is_a: IEV:0000842 ! Binding of RTK-ligand and RTK in extracellular
relationship: part_of IEV:0002632 ! VEGF receptor signaling pathway

[Term]
id: IEV:0002479
name: Dimerization of KDR in plasma membrane
xref_analog: IMR:0000066
is_a: IEV:0000846 ! Dimerization of RTK in plasma membrane
relationship: part_of IEV:0002632 ! VEGF receptor signaling pathway

[Term]
id: IEV:0002480
name: Autophosphorylation of KDR in plasma membrane
xref_analog: IMR:0000066
is_a: IEV:0000843 ! Autophosphorylation of RTK in plasma membrane
relationship: part_of IEV:0002632 ! VEGF receptor signaling pathway

[Term]
id: IEV:0002481
name: Binding of KDR_p and PI3K in cytosol
xref_analog: IMR:0000066
xref_analog: IMR:0000265
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002632 ! VEGF receptor signaling pathway

[Term]
id: IEV:0002482
name: Binding of KDR_p and VRAP in cytosol
xref_analog: IMR:0000066
xref_analog: IMR:0001652
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002632 ! VEGF receptor signaling pathway

[Term]
id: IEV:0002483
name: Binding of KDR_p and PLC gamma in cytosol
xref_analog: IMR:0000066
xref_analog: IMR:0000285
is_a: IEV:0000283 ! Binding of RTK and PLC gamma in cytosol
relationship: part_of IEV:0002632 ! VEGF receptor signaling pathway

[Term]
id: IEV:0002484
name: Activation of PKC by DAG in cytosol
xref_analog: IMR:0000245
xref_analog: IMR:0100027
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0002632 ! VEGF receptor signaling pathway

[Term]
id: IEV:0002485
name: Activation of Raf-1 by PKC in cytosol
exact_synonym: "Activation of c-Raf1 by PKC" []
xref_analog: IMR:0000245
xref_analog: IMR:0100355
is_a: IEV:0001362 ! Activation of Raf by PKC in cytosol
relationship: part_of IEV:0002632 ! VEGF receptor signaling pathway

[Term]
id: IEV:0002486
name: Binding of FGF and FGFR in extracellular
xref_analog: IMR:0000049
xref_analog: IMR:0000080
is_a: IEV:0000842 ! Binding of RTK-ligand and RTK in extracellular
relationship: part_of IEV:0002626 ! FGF receptor signaling pathway

[Term]
id: IEV:0002487
name: Dimerization of FGFR in plasma membrane
xref_analog: IMR:0000080
is_a: IEV:0000846 ! Dimerization of RTK in plasma membrane
relationship: part_of IEV:0002626 ! FGF receptor signaling pathway

[Term]
id: IEV:0002488
name: Autophosphorylation of FGFR in plasma membrane
xref_analog: IMR:0000080
is_a: IEV:0000843 ! Autophosphorylation of RTK in plasma membrane
relationship: part_of IEV:0002626 ! FGF receptor signaling pathway

[Term]
id: IEV:0002489
name: Binding of FGFR_p and PLC gamma in cytosol
xref_analog: IMR:0000080
xref_analog: IMR:0000285
is_a: IEV:0000283 ! Binding of RTK and PLC gamma in cytosol
relationship: part_of IEV:0002626 ! FGF receptor signaling pathway

[Term]
id: IEV:0002490
name: Binding of FGFR_p and FRS2 in cytosol
xref_analog: IMR:0000080
xref_analog: IMR:0001836
is_a: IEV:0003824 ! Binding of FGFR and adaptor protein in cytosol

[Term]
id: IEV:0002491
name: Phosphorylation of FRS2 by FGFR_p in cytosol
xref_analog: IMR:0000080
xref_analog: IMR:0001836
is_a: IEV:0003825 ! Phosphorylation of adaptor protein by FGFR in cytosol

[Term]
id: IEV:0002492
name: Binding of Grb2 and FRS2_p in cytosol
xref_analog: IMR:0000340
xref_analog: IMR:0001836
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002626 ! FGF receptor signaling pathway
relationship: part_of IEV:0003405 ! FGFR1 signaling pathway

[Term]
id: IEV:0002493
name: Phosphorylation of Gab1 by FRS2 in cytosol
xref_analog: IMR:0001410
xref_analog: IMR:0001836
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0002626 ! FGF receptor signaling pathway

[Term]
id: IEV:0002494
name: Binding of Gab1_p and PI3K in cytosol
alt_id: IEV:0002462
exact_synonym: "Binding of Gab1 and PI3K" []
xref_analog: IMR:0000265
xref_analog: IMR:0001410
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002626 ! FGF receptor signaling pathway
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0002495
name: Binding of Ras and PI3K in cytosol
xref_analog: IMR:0000265
xref_analog: IMR:0000290
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002626 ! FGF receptor signaling pathway

[Term]
id: IEV:0002496
name: Binding of Ci/Gli and Slmb/beta-TrCP in cytosol
xref_analog: IMR:0001372
xref_analog: IMR:0100471
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002596 ! Ci/Gli processing signaling

[Term]
id: IEV:0002497
name: Binding of BMP2:BMP receptor I and BMP receptor II in plasma membrane
xref_analog: IMR:0000702
xref_analog: IMR:0001424
xref_analog: IMR:0001425
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0002338 ! BMP2 signaling pathway(through TAK1)

[Term]
id: IEV:0002498
name: Binding of BMP receptor I and XIAP in cytosol
xref_analog: IMR:0001425
xref_analog: IMR:0100331
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002338 ! BMP2 signaling pathway(through TAK1)

[Term]
id: IEV:0002499
name: Binding of Smad6 and TAK1 in cytosol
xref_analog: IMR:0000232
xref_analog: IMR:0100317
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002505 ! Negative regulation of BMP2 signaling pathway (through TAK1)

[Term]
id: IEV:0002500
name: Ventral mesoderm specification
relationship: part_of IEV:0002538 ! Mesoderm morphogenesis

[Term]
id: IEV:0002501
name: Regulation of BMP2 signaling pathway (through Smad)
is_a: IEV:0000882 ! Regulation of BMP signaling pathway
relationship: regulates IEV:0002337 ! BMP2 signaling pathway(through Smad)

[Term]
id: IEV:0002502
name: Negative regulation of BMP2 signaling pathway (through Smad)
is_a: IEV:0000883 ! Negative regulation of BMP signaling pathway
is_a: IEV:0002501 ! Regulation of BMP2 signaling pathway (through Smad)
relationship: negatively_regulates IEV:0002337 ! BMP2 signaling pathway(through Smad)

[Term]
id: IEV:0002503
name: Positive regulation of BMP2 signaling pathway (through Smad)
is_a: IEV:0000884 ! Positive regulation of BMP signaling pathway
is_a: IEV:0002501 ! Regulation of BMP2 signaling pathway (through Smad)
relationship: positively_regulates IEV:0002337 ! BMP2 signaling pathway(through Smad)

[Term]
id: IEV:0002504
name: Regulation of BMP2 signaling pathway (through TAK1)
is_a: IEV:0000882 ! Regulation of BMP signaling pathway
relationship: regulates IEV:0002338 ! BMP2 signaling pathway(through TAK1)

[Term]
id: IEV:0002505
name: Negative regulation of BMP2 signaling pathway (through TAK1)
is_a: IEV:0000883 ! Negative regulation of BMP signaling pathway
is_a: IEV:0002504 ! Regulation of BMP2 signaling pathway (through TAK1)
relationship: negatively_regulates IEV:0002338 ! BMP2 signaling pathway(through TAK1)

[Term]
id: IEV:0002506
name: Positive regulation of BMP2 signaling pathway (through TAK1)
is_a: IEV:0000884 ! Positive regulation of BMP signaling pathway
is_a: IEV:0002504 ! Regulation of BMP2 signaling pathway (through TAK1)
relationship: positively_regulates IEV:0002338 ! BMP2 signaling pathway(through TAK1)

[Term]
id: IEV:0002507
name: Binding of BMP receptor II and BAMBI in cytosol
xref_analog: IMR:0000702
xref_analog: IMR:0001831
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002502 ! Negative regulation of BMP2 signaling pathway (through Smad)

[Term]
id: IEV:0002508
name: Binding of BMP receptor I and Smad7 in cytosol
xref_analog: IMR:0001425
xref_analog: IMR:0100318
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002502 ! Negative regulation of BMP2 signaling pathway (through Smad)

[Term]
id: IEV:0002509
name: Binding of BMP receptor I and Smad6 in cytosol
xref_analog: IMR:0001425
xref_analog: IMR:0100317
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002502 ! Negative regulation of BMP2 signaling pathway (through Smad)

[Term]
id: IEV:0002510
name: Binding of Smad1_p and Smad6 in cytosol
xref_analog: IMR:0100310
xref_analog: IMR:0100317
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002502 ! Negative regulation of BMP2 signaling pathway (through Smad)

[Term]
id: IEV:0002511
name: Binding of DIF:Relish and NF-kappaB binding sequence [Drosophila]
def: "OBSOLETE: remap to 'Binding of DIF:Relish and NF-kappaB binding sequence' IEV:0003460." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002512
name: Transcription of defensin by DIF:Relish [Drosophila]
def: "OBSOLETE: remap to 'Transcription of defensin by DIF:Relish' IEV:0003481." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002513
name: Regulation of Drosophila Toll receptor signaling
def: "OBSOLETE: remap to 'Regulation of Toll receptor signaling' IEV:0003569." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002514
name: Negative regulation of Toll receptor signaling
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the Tl signaling pathway." [GO:0045751]
exact_synonym: "down regulation of Toll signaling pathway" []
exact_synonym: "negative regulation of Tl signaling pathway" []
exact_synonym: "Negative regulation of Toll receptor signaling pathway" []
xref_analog: GO:0045751
is_a: IEV:0003569 ! Regulation of Toll receptor signaling
relationship: negatively_regulates IEV:0003490 ! Toll receptor signaling

[Term]
id: IEV:0002515
name: Positive regulation of Toll receptor signaling
def: "Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway." [GO:0045752]
exact_synonym: "positive regulation of Tl signaling pathway" []
exact_synonym: "Positive regulation of Toll receptor signaling pathway" []
exact_synonym: "up regulation of Toll signaling pathway" []
xref_analog: GO:0045752
is_a: IEV:0001669 ! Positive signal transduction regulation pathway
is_a: IEV:0003569 ! Regulation of Toll receptor signaling
relationship: positively_regulates IEV:0003490 ! Toll receptor signaling

[Term]
id: IEV:0002516
name: Negative regulation of (Activation of PSH by GNBP3)
is_a: IEV:0001670 ! Negative signal transduction regulation pathway
is_a: IEV:0002514 ! Negative regulation of Toll receptor signaling

[Term]
id: IEV:0002517
name: Binding of PSH and NEC in extracellular
xref_analog: IMR:0001796
xref_analog: IMR:0001797
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0002516 ! Negative regulation of (Activation of PSH by GNBP3)

[Term]
id: IEV:0002518
name: Proteasome degradation of Cactus_p by 26S proteasome in cytosol
xref_analog: IMR:0000310
xref_analog: IMR:0001805
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0003506 ! DIF signaling
relationship: part_of IEV:0003507 ! Dorsal signaling
relationship: part_of IEV:0003508 ! DIF:Dorsal signaling

[Term]
id: IEV:0002519
name: Cellular defense (Activated blood cell)
def: "A defense response that is mediated by cells." [GO:0006968]
exact_synonym: "cellular defense response" [GO:0006968]
xref_analog: GO:0006968
is_a: IEV:0001337 ! Response to stress

[Term]
id: IEV:0002520
name: Phosphorylation of Smad1 by BMP receptor I_p in cytosol
xref_analog: IMR:0001425
xref_analog: IMR:0100310
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0002337 ! BMP2 signaling pathway(through Smad)

[Term]
id: IEV:0002521
name: Binding of Smad1_p:Smad4 and OAZ in inner space of nucleus
xref_analog: IMR:0001948
xref_analog: IMR:0100310
xref_analog: IMR:0100315
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0002337 ! BMP2 signaling pathway(through Smad)

[Term]
id: IEV:0002522
name: Binding of Smad1:Smad4:OAZ complex and BRE in inner space of nucleus
xref_analog: IMR:0001948
xref_analog: IMR:0100310
xref_analog: IMR:0100315
is_a: IEV:0000156 ! Binding of R-Smad:Smad4 complex, Coactivator and responsive element in inner space of nucleus
relationship: part_of IEV:0002337 ! BMP2 signaling pathway(through Smad)

[Term]
id: IEV:0002523
name: Clustering of integrins in plasma membrane
xref_analog: IMR:0000172
xref_analog: PubMed:10446041
xref_analog: PubMed:15179030
is_a: IEV:0002525 ! Clustering in plasma membrane
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)

[Term]
id: IEV:0002524
name: Clustering
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0002525
name: Clustering in plasma membrane
is_a: IEV:0002524 ! Clustering

[Term]
id: IEV:0002526
name: Complex formation of integrin complex, caveolin-1, Fyn and Shc
xref_analog: IMR:0000172
xref_analog: IMR:0000347
xref_analog: IMR:0001647
xref_analog: IMR:0100352
is_a: IEV:0002529 ! Complex formation of integrin complex, caveolin, Fyn and Shc

[Term]
id: IEV:0002527
name: Binding of integrin alpha and caveolin-1 in plasma membrane
xref_analog: IMR:0000173
xref_analog: IMR:0001647
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0002526 ! Complex formation of integrin complex, caveolin-1, Fyn and Shc

[Term]
id: IEV:0002528
name: Binding of caveolin-1 and Fyn in plasma membrane
xref_analog: IMR:0001647
xref_analog: IMR:0100352
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0002526 ! Complex formation of integrin complex, caveolin-1, Fyn and Shc

[Term]
id: IEV:0002529
name: Complex formation of integrin complex, caveolin, Fyn and Shc
xref_analog: IMR:0000172
xref_analog: IMR:0000347
xref_analog: IMR:0000515
xref_analog: IMR:0100352
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)

[Term]
id: IEV:0002530
name: GDP-GTP exchange of Rac1 by RhoGEF in cytosol
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: IMR:0001501
xref_analog: IMR:0001954
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)
relationship: part_of IEV:0001200 ! Integrin signaling pathway (through PI3K, Vav and Rac)

[Term]
id: IEV:0002531
name: GDP-GTP exchange of Cdc42 by RhoGEF in cytosol
xref_analog: IMR:0000699
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: IMR:0001954
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0000124 ! Integrin signaling pathway

[Term]
id: IEV:0002532
name: GDP-GTP exchange of RhoA by RhoGEF in cytosol
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: IMR:0001953
xref_analog: IMR:0001954
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0002533
name: Transcription of cyclin D1 gene in nucleus
xref_analog: IMR:0100615
is_a: IEV:0003549 ! Transcription in nucleus
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac and JNK cascade)

[Term]
id: IEV:0002534
name: Filopodium formation
def: "The assembly of a filopodium, a very long microspike extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or by the growth cone of a developing nerve cell axon." [GO:0046847]
exact_synonym: "filopodia biosynthesis" []
exact_synonym: "filopodia formation" []
xref_analog: GO:0046847
is_a: IEV:0001320 ! Cellular component organization

[Term]
id: IEV:0002535
name: Cell fate determination
def: "Process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GO:0001709]
xref_analog: GO:0001709
relationship: part_of IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0002536
name: Mesodermal cell fate determination
def: "Process by which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GO:0007500]
exact_synonym: "mesoderm cell fate determination" [GO:0007500]
xref_analog: GO:0007500
is_a: IEV:0002535 ! Cell fate determination
relationship: part_of IEV:0000397 ! Embryonic development
relationship: part_of IEV:0000447 ! Anatomical structure morphogenesis
relationship: part_of IEV:0002538 ! Mesoderm morphogenesis

[Term]
id: IEV:0002537
name: Mesoderm development
def: "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GO:0007498]
xref_analog: GO:0007498
is_a: IEV:0003796 ! Tissue development

[Term]
id: IEV:0002538
name: Mesoderm morphogenesis
xref_analog: GO:0048332
relationship: part_of IEV:0002537 ! Mesoderm development

[Term]
id: IEV:0002539
name: Wnt secretory pathway
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0002540
name: Endoderm development
def: "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GO:0007492]
xref_analog: GO:0007492
is_a: IEV:0003796 ! Tissue development

[Term]
id: IEV:0002541
name: Endodermal cell fate determination
def: "Process by which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GO:0007493]
exact_synonym: "endoderm cell fate determination" [GO:0007493]
xref_analog: GO:0007493
is_a: IEV:0002535 ! Cell fate determination
relationship: part_of IEV:0002540 ! Endoderm development

[Term]
id: IEV:0002542
name: Signaling with Wnt
xref_analog: REACT:11045.1
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0002543
name: Signaling without Wnt
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0002544
name: Stabilization and accumulation of cytoplasmic beta-catenin in cytosol
xref_analog: IMR:0000177
is_a: IEV:0002546 ! Accumulation in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0002545
name: Accumulation
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0002546
name: Accumulation in cytosol
is_a: IEV:0002545 ! Accumulation

[Term]
id: IEV:0002547
name: Transcription of Ubx gene in nucleus
xref_analog: IMR:0001978
is_a: IEV:0002282 ! Transcription by beta-catenin:TCF complex in nucleus

[Term]
id: IEV:0002548
name: Transcription of Engrailed gene in nucleus
xref_analog: IMR:0001979
is_a: IEV:0002282 ! Transcription by beta-catenin:TCF complex in nucleus

[Term]
id: IEV:0002549
name: Wnt signaling pathway (C. elegans)
def: "OBSOLETE: remap to 'Wnt signaling pathway' IEV:0000027." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002550
name: Transcription of end-1 gene in nucleus
xref_analog: IMR:0001977
is_a: IEV:0002282 ! Transcription by beta-catenin:TCF complex in nucleus

[Term]
id: IEV:0002551
name: Transcription by beta-catenin TCF complex (C. elegans)
def: "OBSOLETE: remap to 'Transcription by beta-catenin TCF complex' IEV:0002282." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002552
name: Activation of NLK by TAK1 in cytosol
xref_analog: IMR:0000232
xref_analog: IMR:0001164
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0002553
name: Activation of APR-1 in cytosol
xref_analog: IMR:0001197
is_a: IEV:0002554 ! Activation of APC in cytosol

[Term]
id: IEV:0002554
name: Activation of APC in cytosol
xref_analog: IMR:0000205
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0002555
name: Activation of GSK3beta in cytosol
xref_analog: IMR:0100737
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0002556
name: Activation of SGG-1 in cytosol
xref_analog: IMR:0001246
is_a: IEV:0002555 ! Activation of GSK3beta in cytosol

[Term]
id: IEV:0002557
name: Binding of Notch1 and Delta1 in extracellular
xref_analog: IMR:0100714
xref_analog: IMR:0100720
is_a: IEV:0001181 ! Binding of Notch and Delta in extracellular

[Term]
id: IEV:0002558
name: Binding of Notch and Serrate/Jagged in extracellular
xref_analog: IMR:0001919
xref_analog: IMR:0100712
is_a: IEV:0001168 ! Binding of Notch and DSL ligand in extracellular

[Term]
id: IEV:0002559
name: Glycosylation of Notch by Fringe in cytosol
xref_analog: IMR:0001852
xref_analog: IMR:0100712
is_a: IEV:0002561 ! Glycosylation in cytosol
relationship: part_of IEV:0001180 ! Positive regulation of Notch signaling pathway

[Term]
id: IEV:0002560
name: Glycosylation
def: "The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer. Reaction that can affect Ser, Thr, Cys, Arg, and Asn residues. This reaction is known to be reversible in the case of Asn substrate." [MI:0559]
xref_analog: EC:2.4.-.-
xref_analog: MI:0559
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0002561
name: Glycosylation in cytosol
is_a: IEV:0002560 ! Glycosylation

[Term]
id: IEV:0002562
name: Binding of Notch (ICN) and Numb in cytosol
xref_analog: IMR:0001955
xref_analog: IMR:0100712
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001179 ! Negative regulation of Notch signaling pathway

[Term]
id: IEV:0002563
name: Ubiquitination of Notch by Su(dx)/Itch in cytosol
xref_analog: IMR:0001943
xref_analog: IMR:0100712
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0001179 ! Negative regulation of Notch signaling pathway

[Term]
id: IEV:0002564
name: Notch degradation signaling
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
relationship: part_of IEV:0001179 ! Negative regulation of Notch signaling pathway

[Term]
id: IEV:0002565
name: Phosphorylation of Notch (NIC) in cytosol
xref_analog: IMR:0100712
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0002564 ! Notch degradation signaling

[Term]
id: IEV:0002566
name: Ubiquitination of Notch (NIC) by SCF ubiquitin ligase complex including sel-10 in cytosol
xref_analog: IMR:0001931
xref_analog: IMR:0100470
xref_analog: IMR:0100712
is_a: IEV:0000026 ! Ubiquitination in cytosol
is_a: IEV:0002564 ! Notch degradation signaling

[Term]
id: IEV:0002567
name: Proteasome degradation of Notch (NIC) by 26S proteasome in cytosol
xref_analog: IMR:0000310
xref_analog: IMR:0100712
is_a: IEV:0000021 ! Proteasome degradation in cytosol
is_a: IEV:0002564 ! Notch degradation signaling

[Term]
id: IEV:0002568
name: Notch secretory pathway
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0002569
name: Transcription of HES gene in nucleus
xref_analog: IMR:0001980
is_a: IEV:0001177 ! Transcription by CSL:Notch (NIC) in nucleus

[Term]
id: IEV:0002570
name: Hedgehog signaling pathway
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GO:0007224]
exact_synonym: "hh signaling pathway" [GO:0007224]
exact_synonym: "smoothened signaling pathway" [GO:0007224]
xref_analog: GO:0007224
xref_analog: KEGG:hsa04340
is_a: IEV:0001842 ! Signaling pathway

[Term]
id: IEV:0002571
name: Cleavage
def: "Covalent bond breakage in a molecule leading to the formation of smaller molecules." [MI:0194]
xref_analog: MI:0194
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0002572
name: Autocleavage
is_a: IEV:0002571 ! Cleavage

[Term]
id: IEV:0002573
name: Cholesterol modification
is_a: IEV:0002681 ! lipid addition

[Term]
id: IEV:0002574
name: Cholesterol modification in ER
is_a: IEV:0002573 ! Cholesterol modification

[Term]
id: IEV:0002575
name: Autocleavage in ER
is_a: IEV:0002572 ! Autocleavage

[Term]
id: IEV:0002576
name: Secretory pathway of Hedgehog
relationship: part_of IEV:0002570 ! Hedgehog signaling pathway

[Term]
id: IEV:0002579
name: Palmitoylation of hedgehog in ER
xref_analog: IMR:0000004
is_a: IEV:0001937 ! Palmitoylation in ER
relationship: part_of IEV:0002576 ! Secretory pathway of Hedgehog

[Term]
id: IEV:0002580
name: Translocation of hedgehog from ER to plasma membrane
xref_analog: IMR:0000004
is_a: IEV:0001941 ! Translocation from ER to plasma membrane
relationship: part_of IEV:0002576 ! Secretory pathway of Hedgehog

[Term]
id: IEV:0002581
name: Intercellular transport
def: "The movement of substances between cells in a multicellular organism." [GO:0010496]
exact_synonym: "Cell-to-cell movement" []
xref_analog: GO:0010496
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0002582
name: cell-to-cell movement of Hedgehog
xref_analog: IMR:0000004
is_a: IEV:0002581 ! Intercellular transport
relationship: part_of IEV:0002570 ! Hedgehog signaling pathway

[Term]
id: IEV:0002583
name: Translocation of HSPG from Golgi to plasma membrane
xref_analog: IMR:0001125
is_a: IEV:0001167 ! Translocation from Golgi to plasma membrane
relationship: part_of IEV:0002570 ! Hedgehog signaling pathway

[Term]
id: IEV:0002584
name: Translocation of Dlp/Dally from Golgi to plasma membrane
xref_analog: IMR:0002958
is_a: IEV:0002583 ! Translocation of HSPG from Golgi to plasma membrane

[Term]
id: IEV:0002585
name: Glycosylation of HSPG by Exostosin in cytosol
xref_analog: IMR:0001125
xref_analog: IMR:0001396
is_a: IEV:0002561 ! Glycosylation in cytosol
relationship: part_of IEV:0002570 ! Hedgehog signaling pathway

[Term]
id: IEV:0002586
name: Glycosylation of Dlp/Dally by Tout-velu in cytosol
xref_analog: IMR:0001392
xref_analog: IMR:0002958
is_a: IEV:0002585 ! Glycosylation of HSPG by Exostosin in cytosol

[Term]
id: IEV:0002587
name: Activation of Smo
xref_analog: IMR:0100802
is_a: IEV:0000038 ! Activation in unidentified cellular location
relationship: part_of IEV:0002570 ! Hedgehog signaling pathway

[Term]
id: IEV:0002588
name: Inactivation of Smo by Ptc in plasma membrane
xref_analog: IMR:0000141
xref_analog: IMR:0100802
is_a: IEV:0003548 ! Inactivation in plasma membrane
relationship: part_of IEV:0002570 ! Hedgehog signaling pathway

[Term]
id: IEV:0002589
name: Inactivation of Ptc by Hedgehog in extracellular
xref_analog: IMR:0000004
xref_analog: IMR:0000141
is_a: IEV:0000245 ! Inactivation in extracellular
relationship: part_of IEV:0002570 ! Hedgehog signaling pathway

[Term]
id: IEV:0002590
name: Binding of Ptc and Smo in plasma membrane
xref_analog: IMR:0000141
xref_analog: IMR:0100802
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0002588 ! Inactivation of Smo by Ptc in plasma membrane

[Term]
id: IEV:0002591
name: Binding of Hedgehog and Ptc in extracellular
xref_analog: IMR:0000004
xref_analog: IMR:0000141
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0002589 ! Inactivation of Ptc by Hedgehog in extracellular

[Term]
id: IEV:0002592
name: Binding of Smo and Cos2:Fu:Ci/Gli in cytosol
xref_analog: IMR:0001372
xref_analog: IMR:0100802
xref_analog: IMR:0100806
xref_analog: IMR:0100807
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002570 ! Hedgehog signaling pathway

[Term]
id: IEV:0002594
name: Binding of Sufu and Ci/Gli in cytosol
xref_analog: IMR:0001372
xref_analog: IMR:0003011
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002570 ! Hedgehog signaling pathway

[Term]
id: IEV:0002595
name: Binding of Ci/Gli, Fu and Cos2 in cytosol
xref_analog: IMR:0001372
xref_analog: IMR:0100806
xref_analog: IMR:0100807
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002596 ! Ci/Gli processing signaling

[Term]
id: IEV:0002596
name: Ci/Gli processing signaling
relationship: part_of IEV:0002570 ! Hedgehog signaling pathway

[Term]
id: IEV:0002597
name: Phosphorylation of Ci/Gli by PKA in cytosol
xref_analog: IMR:0000249
xref_analog: IMR:0001372
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0002596 ! Ci/Gli processing signaling

[Term]
id: IEV:0002598
name: Phosphorylation of Ci/Gli by CK1 in cytosol
xref_analog: IMR:0001372
xref_analog: IMR:0100809
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0002596 ! Ci/Gli processing signaling

[Term]
id: IEV:0002599
name: Cell fate commitment
def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GO:0045165]
xref_analog: GO:0045165
relationship: part_of IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0002600
name: Phosphorylation of Ci/Gli by GSK3 in cytosol
xref_analog: IMR:0000257
xref_analog: IMR:0001372
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0002596 ! Ci/Gli processing signaling

[Term]
id: IEV:0002601
name: Cleavage in cytosol
is_a: IEV:0002571 ! Cleavage

[Term]
id: IEV:0002602
name: Cleavage of Ci/Gli in cytosol
xref_analog: IMR:0001372
is_a: IEV:0002601 ! Cleavage in cytosol
relationship: part_of IEV:0002596 ! Ci/Gli processing signaling

[Term]
id: IEV:0002603
name: Nuclear import of Ci/Gli
xref_analog: IMR:0001372
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0002570 ! Hedgehog signaling pathway

[Term]
id: IEV:0002604
name: Nuclear import of Ci/GliR
xref_analog: IMR:0001372
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0002570 ! Hedgehog signaling pathway

[Term]
id: IEV:0002605
name: Transcription of Hh target gene in nucleus
xref_analog: IMR:0000004
is_a: IEV:0003549 ! Transcription in nucleus
relationship: part_of IEV:0003778 ! Gene expression by Ci/Gli

[Term]
id: IEV:0002606
name: Transcription of ptc gene in nucleus
xref_analog: IMR:0000141
is_a: IEV:0002605 ! Transcription of Hh target gene in nucleus

[Term]
id: IEV:0002607
name: Transcription of dpp gene in nucleus
xref_analog: IMR:0001981
is_a: IEV:0002605 ! Transcription of Hh target gene in nucleus

[Term]
id: IEV:0002608
name: Cell-cell signaling involved in cell fate commitment
def: "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate." [GO:0045168]
xref_analog: GO:0045168
is_a: IEV:0002611 ! Cell-cell signaling
relationship: part_of IEV:0002599 ! Cell fate commitment

[Term]
id: IEV:0002609
name: Induction
def: "Signaling at short range between cells or tissues of different ancestry and developmental potential that results in one cell or tissue effecting a developmental change in the other." [GO:0031128]
xref_analog: GO:0031128
is_a: IEV:0002608 ! Cell-cell signaling involved in cell fate commitment

[Term]
id: IEV:0002610
name: Lateral inhibition
def: "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GO:0046331]
xref_analog: GO:0046331
is_a: IEV:0002608 ! Cell-cell signaling involved in cell fate commitment

[Term]
id: IEV:0002611
name: Cell-cell signaling
def: "Any process that mediates the transfer of information from one cell to another." [GO:0007267]
xref_analog: GO:0007267
is_a: IEV:0001319 ! Cell communication

[Term]
id: IEV:0002612
name: Translocation from ER to Golgi
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0002613
name: Translocation from Golgi to cytosol
relationship: part_of IEV:0001167 ! Translocation from Golgi to plasma membrane

[Term]
id: IEV:0002614
name: Translocation from cytosol to Golgi
is_a: IEV:0000009 ! Translocation
relationship: part_of IEV:0002612 ! Translocation from ER to Golgi

[Term]
id: IEV:0002615
name: Translocation of Arrow/LRP5/6 from ER to Golgi
xref_analog: IMR:0002951
is_a: IEV:0002612 ! Translocation from ER to Golgi

[Term]
id: IEV:0002616
name: Translocation of LRP6 from ER to Golgi
xref_analog: IMR:0000970
is_a: IEV:0002615 ! Translocation of Arrow/LRP5/6 from ER to Golgi

[Term]
id: IEV:0002617
name: Translocation of Arrow/LRP5/6 from Golgi to plasma membrane
xref_analog: IMR:0002951
is_a: IEV:0001167 ! Translocation from Golgi to plasma membrane

[Term]
id: IEV:0002618
name: Translocation of LRP6 from Golgi to plasma membrane
xref_analog: IMR:0000970
is_a: IEV:0002617 ! Translocation of Arrow/LRP5/6 from Golgi to plasma membrane

[Term]
id: IEV:0002619
name: Binding of Notch and Serrate in extracellular
xref_analog: IMR:0001909
xref_analog: IMR:0100712
is_a: IEV:0002558 ! Binding of Notch and Serrate/Jagged in extracellular

[Term]
id: IEV:0002620
name: Binding of Notch (ICN) and Deltex in cytosol
xref_analog: IMR:0001935
xref_analog: IMR:0100712
is_a: IEV:0000013 ! Binding in cytosol

[Term]
id: IEV:0002621
name: Binding of Notch (ICN):CSL and Nrarp in inner space of nucleus
xref_analog: IMR:0001959
xref_analog: IMR:0100712
xref_analog: IMR:0100723
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001179 ! Negative regulation of Notch signaling pathway

[Term]
id: IEV:0002622
name: Dissociation of Axin, APC, GSK3beta and beta-catenin
def: "OBSOLETE: remap to 'Dissociation of Axin, APC, GSK3beta and beta-catenin in cytosol' IEV:0003870." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002623
name: Binding of EGFR and Grb2 in cytosol
alt_id: IEV:0002445
exact_synonym: "Binding of (GRB2:SOS) and (EGF:EGFR_p)" []
xref_analog: IMR:0000081
xref_analog: IMR:0000340
is_a: IEV:0000844 ! Binding of RTK and Grb2 in cytosol
relationship: part_of IEV:0000865 ! EGF receptor signaling pathway

[Term]
id: IEV:0002624
name: Binding of EGFR and Shc in cytosol
alt_id: IEV:0002443
exact_synonym: "Binding of SHC and (EGF:EGFR_p)" []
xref_analog: IMR:0000081
xref_analog: IMR:0000347
is_a: IEV:0000845 ! Binding of RTK and Shc in cytosol
relationship: part_of IEV:0000865 ! EGF receptor signaling pathway

[Term]
id: IEV:0002625
name: Nuclear import of ERK1/2_p
xref_analog: IMR:0000227
is_a: IEV:0000466 ! Nuclear import of ERK_p

[Term]
id: IEV:0002626
name: FGF receptor signaling pathway
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GO:0008543]
exact_synonym: "FGF signaling pathway" [GO:0008543]
exact_synonym: "FGFR signaling pathway" [GO:0008543]
exact_synonym: "fibroblast growth factor receptor signaling pathway" [GO:0008543]
xref_analog: GO:0008543
is_a: IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0003790 ! Mesoderm migration
relationship: part_of IEV:0003791 ! Open tracheal system development

[Term]
id: IEV:0002627
name: HGF receptor signaling pathway
def: "The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands." [GO:0048012]
exact_synonym: "hepatocyte growth factor receptor signaling pathway" [GO:0048012]
exact_synonym: "HGF signaling pathway" []
exact_synonym: "HGFR signaling pathway" [GO:0048012]
xref_analog: GO:0048012
is_a: IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000105 ! Cell adhesion
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0002628
name: Binding of Met_p and Shc in cytosol
alt_id: IEV:0002467
exact_synonym: "Binding of (HGF:Met_p) and Shc" []
xref_analog: IMR:0000071
xref_analog: IMR:0000347
is_a: IEV:0000845 ! Binding of RTK and Shc in cytosol
relationship: part_of IEV:0002627 ! HGF receptor signaling pathway

[Term]
id: IEV:0002629
name: Binding of TRK and Shc in cytosol
alt_id: IEV:0002473
exact_synonym: "Binding of SHC and (NGF:TRK_p)" []
xref_analog: IMR:0000072
xref_analog: IMR:0000347
is_a: IEV:0000845 ! Binding of RTK and Shc in cytosol
relationship: part_of IEV:0000866 ! NGF receptor signaling pathway

[Term]
id: IEV:0002630
name: Binding of TRK and Grb2 in cytosol
alt_id: IEV:0002475
exact_synonym: "Binding of (NGF:TRK_p) and (GRB2:SOS)" []
xref_analog: IMR:0000072
xref_analog: IMR:0000340
is_a: IEV:0000844 ! Binding of RTK and Grb2 in cytosol
relationship: part_of IEV:0000866 ! NGF receptor signaling pathway

[Term]
id: IEV:0002631
name: Phosphorylation of Shc by RTK in cytosol
xref_analog: IMR:0000063
xref_analog: IMR:0000347
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000830 ! RTK signaling pathway

[Term]
id: IEV:0002632
name: VEGF receptor signaling pathway
def: "The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands." [GO:0048010]
exact_synonym: "vascular endothelial growth factor receptor signaling pathway" [GO:0048010]
exact_synonym: "VEGF signaling pathway" [GO:0048010]
xref_analog: GO:0048010
xref_analog: KEGG:hsa04370
is_a: IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000104 ! Cell migration
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0002258 ! Actin filament reorganization during cell cycle

[Term]
id: IEV:0002633
name: Heterotrimeric GPCR signaling pathway (through Angiotensin and G alpha q)
is_a: IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)

[Term]
id: IEV:0002634
name: Heterotrimeric GPCR signaling pathway (through G alpha q)
is_a: IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0002635
name: Heterotrimeric GPCR signaling pathway (through G alpha o)
is_a: IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0002636
name: Heterotrimeric GPCR signaling pathway (through G alpha t)
is_a: IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0002637
name: Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)
is_a: IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)

[Term]
id: IEV:0002638
name: Translation of antimicrobial protein in cytosol
xref_analog: IMR:0001815
is_a: IEV:0003550 ! Translation in cytosol
relationship: part_of IEV:0003464 ! Expression of antimicrobial peptide by Relish
relationship: part_of IEV:0003511 ! Expression of antimicrobial peptide by DIF
relationship: part_of IEV:0003525 ! Expression of antimicrobial peptide by DIF:Dorsal
relationship: part_of IEV:0003533 ! Expression of antimicrobial peptide by Dorsal

[Term]
id: IEV:0002639
name: Translation of Defensin [Drosophila]
def: "OBSOLETE: remap to 'Translation of Defensin' IEV:0003487." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002640
name: Transcription of drosocin by Relish [Drosophila]
def: "OBSOLETE: remap to 'Transcription of drosocin by Relish' IEV:0003482." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002641
name: Translation of drosocin [Drosophila]
def: "OBSOLETE: remap to 'Translation of drosocin' IEV:0003488." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002642
name: Transcription of attacin by Relish [Drosophila]
def: "OBSOLETE: remap to 'Transcription of attacin by Relish' IEV:0003476." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002643
name: Translation of attacin [Drosophila]
def: "OBSOLETE: remap to 'Translation of attacin' IEV:0003485." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002644
name: Expression of cecropin by Relish
narrow_synonym: "Expression of cecropin by Relish [Drosophila]" []
xref_analog: IMR:0001814
xref_analog: IMR:0001819
is_a: IEV:0003464 ! Expression of antimicrobial peptide by Relish

[Term]
id: IEV:0002645
name: Transcription of cecropin by Relish [Drosophila]
def: "OBSOLETE: remap to 'Transcription of cecropin by Relish' IEV:0003480." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002646
name: Translation of cecropin [Drosophila]
def: "OBSOLETE: remap to 'Translation of cecropin' IEV:0003486." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002647
name: Transcription of diptericin by Relish [Drosophila]
def: "OBSOLETE: remap to 'Transcription of diptericin by Relish' IEV:0003483." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002648
name: Translation of diptericin [Drosophila]
def: "OBSOLETE: remap to 'Translation of diptericin' IEV:0003489." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002649
name: Transcription of drosomycin by Relish [Drosophila]
def: "OBSOLETE: remap to 'Transcription of drosomycin by Relish' IEV:0003479." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002650
name: Translation of drosomycin [Drosophila]
def: "OBSOLETE: remap to 'Translation of drosomycin' IEV:0003484." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002651
name: Activation of protein kinase by Pelle in cytosol
xref_analog: IMR:0000209
xref_analog: IMR:0001802
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0003490 ! Toll receptor signaling

[Term]
id: IEV:0002652
name: Activation in nucleus
is_a: IEV:0000008 ! Activation

[Term]
id: IEV:0002653
name: Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)
is_a: IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)

[Term]
id: IEV:0002654
name: Transcription of antimicrobial peptide [Drosophila]
def: "OBSOLETE: remap to 'Transcription of antimicrobial peptide' IEV:0003518." [XX:<new dbxref>]
is_obsolete: true

[Term]
id: IEV:0002655
name: Binding of TPO receptor and JAK2 in cytosol
xref_analog: IMR:0000126
xref_analog: IMR:0100320
is_a: IEV:0000051 ! Binding of cytokine receptor and JAK in cytosol
relationship: part_of IEV:0001233 ! TPO signaling pathway (JAK2, STAT3)

[Term]
id: IEV:0002656
name: Binding of TPO and TPO receptor and conformational change of receptors in plasma membrane
xref_analog: IMR:0000015
xref_analog: IMR:0000126
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors in plasma membrane
relationship: part_of IEV:0001233 ! TPO signaling pathway (JAK2, STAT3)

[Term]
id: IEV:0002657
name: Phosphorylation of TPO receptor by JAK2 in cytosol
xref_analog: IMR:0000126
xref_analog: IMR:0100320
is_a: IEV:0000053 ! Phosphorylation of cytokine receptor by Jak in cytosol
relationship: part_of IEV:0001233 ! TPO signaling pathway (JAK2, STAT3)

[Term]
id: IEV:0002658
name: Binding of TPO receptor and STAT3 in cytosol
xref_analog: IMR:0000126
xref_analog: IMR:0000377
is_a: IEV:0000046 ! Binding of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0001233 ! TPO signaling pathway (JAK2, STAT3)

[Term]
id: IEV:0002659
name: Phosphorylation of STAT3 by JAK2_p in cytosol
xref_analog: IMR:0000377
xref_analog: IMR:0100320
is_a: IEV:0000446 ! Phosphorylation of STAT by JAK_p in cytosol
relationship: part_of IEV:0000867 ! EPO signaling pathway
relationship: part_of IEV:0001233 ! TPO signaling pathway (JAK2, STAT3)

[Term]
id: IEV:0002660
name: Dissociation of TPO receptor and STAT3 in cytosol
xref_analog: IMR:0000126
xref_analog: IMR:0000377
is_a: IEV:0002096 ! Dissociation of cytokine receptor and STAT in cytosol
relationship: part_of IEV:0001233 ! TPO signaling pathway (JAK2, STAT3)

[Term]
id: IEV:0002661
name: Covalent binding
def: "Interaction leading to the formation of covalent bond within an autocatalytic molecule or between partners." [MI:0195]
xref_analog: MI:0195
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0002662
name: Colocalization
def: "co-occurrence of interactors in a limited subcellular location or similar distribution in various regions of a cell." [MI:0403]
xref_analog: MI:0403
xref_analog: PubMed:14755292
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0002663
name: Disulfide binding
def: "Covalent bond mediated by 2 sulfur atoms." [MI:0408]
xref_analog: MI:0408
is_a: IEV:0002661 ! Covalent binding

[Term]
id: IEV:0002664
name: Transglutamination
def: "Gln-Lys cross-link catalyzed by a transglutaminase." [MI:0556]
xref_analog: MI:0566
is_a: IEV:0000913 ! Transference
is_a: IEV:0002661 ! Covalent binding

[Term]
id: IEV:0002665
name: DNA cleavage
def: "Covalent bond breakage of a DNA molecule leading to the formation of smaller fragements." [MI:0572]
xref_analog: MI:0572
is_a: IEV:0003607 ! nucleic acid cleavage

[Term]
id: IEV:0002666
name: lipid cleavage
def: "Cleavage of a lipid group covalently bound to a protein residue." [MI:0212]
xref_analog: MI:0212
is_a: IEV:0002571 ! Cleavage

[Term]
id: IEV:0002667
name: Defarnesylation
def: "S-farnesyl-L-cysteined is cleaved and returns a C residue." [MI:0198]
xref_analog: MI:0198
is_a: IEV:0002666 ! lipid cleavage

[Term]
id: IEV:0002668
name: Degeranylation
def: "S-geranylgeranyl-L-cysteine is cleaved and returns a C residue." [MI:0200]
xref_analog: MI:0200
is_a: IEV:0002666 ! lipid cleavage

[Term]
id: IEV:0002669
name: Demyristoylation
def: "N6-myristoyl-L-lysine is cleaved and returns a K residue." [MI:0201]
xref_analog: MI:0201
is_a: IEV:0002666 ! lipid cleavage

[Term]
id: IEV:0002670
name: Depalmitoylation
def: "S-palmitoyl-L-cysteine, N6-palmitoyl-L-lysine, O-palmitoyl-L-threonine or O-palmitoyl-L-serine are cleaved and return C,K,T or S residues." [MI:0202]
xref_analog: MI:0202
is_a: IEV:0002666 ! lipid cleavage

[Term]
id: IEV:0002671
name: mRNA cleavage
def: "Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [MI:0571]
xref_analog: MI:0571
is_a: IEV:0003606 ! RNA cleavage

[Term]
id: IEV:0002672
name: Protein cleavage
def: "Covalent modification of a polypeptide occuring during its maturation or its proteolytic degradation." [MI:0570]
xref_analog: MI:0570
is_a: IEV:0002571 ! Cleavage

[Term]
id: IEV:0002673
name: Deglycosylation
def: "Reaction catalyzed by PNGase, a deglycosylating enzyme that promotes the hydrolysis of the beta-aspartylglycosylamine bond of aspargine-linked glycopeptides and glycoproteins." [MI:0558]
xref_analog: MI:0558
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0002674
name: Formylation
def: "Reaction that can affect K or G residues." [MI:0207]
xref_analog: EC:2.1.2.2
xref_analog: EC:2.1.2.3
xref_analog: EC:2.1.2.9
xref_analog: MI:0207
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0002675
name: Amidation
def: "Irreversible reaction that can affect A,R,N,D,C,Q,E,G,H,I,L,K,M,F,P,S,T,W,Y or V residues." [MI:0193]
xref_analog: EC:6.3.1.-
xref_analog: MI:0193
is_a: IEV:0000912 ! Ligation

[Term]
id: IEV:0002676
name: Deformylation
def: "N6-formyl-L-lysine is cleaved and returns a K residue." [MI:0199]
xref_analog: MI:0199
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0002677
name: Neddylation
def: "Reversible reaction that create a covalent bond between a Glycine residue of an ubiquitine like NEDD8 protein and a lysine residue of the target." [MI:0567]
xref_analog: MI:0567
is_a: IEV:0000912 ! Ligation

[Term]
id: IEV:0002678
name: Deneddylation
def: "Cleavage of the G-K bond and release of the NEDD8 ubiquitin like proteins. Deneddylation, which removes the NEDD8 moiety, requires the isopeptidase activity of the COP9 signalosome." [MI:0569]
xref_analog: MI:0569
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0002679
name: Desumoylation
def: "Cleavage of the G-K bond and release of the SUMO ubiquitin like proteins." [MI:0568]
xref_analog: MI:0568
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0002680
name: Deubiquitination
def: "Cleavage of the G-K bond and release of ubiquitin or ubiquitin like proteins." [MI:0204]
xref_analog: MI:0204
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0002681
name: lipid addition
def: "Covalent or non covalent binding of lipid group on a protein residue." [MI:0211]
xref_analog: MI:0211
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0002682
name: genetic interaction
def: "Functional relationship among genes revealed by the phenotype of cells carrying combined mutations of those genes." [MI:0208]
xref_analog: MI:0208
xref_analog: PubMed:14755292
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0002683
name: suppression
def: "A supressed gene mutation cause of an altered phenotype that is reverted to wild type phenotype when cell also carry a suppressor gene with a specific mutation or altered expression level.\nOBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796." [MI:0261]
xref_analog: MI:0261
is_obsolete: true

[Term]
id: IEV:0002684
name: suppression expression alteration
def: "An altered expression is the suppressor of a phenotype.\nOBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'expression level alteration' MI:0803. " [MI:0265]
xref_analog: MI:0265
is_obsolete: true

[Term]
id: IEV:0002685
name: suppression overexpression
def: "Overexpression is the suppressor of a phenotpe.\nOBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'over expressed' MI:0506. " [MI:0266]
xref_analog: MI:0266
is_obsolete: true

[Term]
id: IEV:0002686
name: suppression underexpression
def: "Underexpression is the suppressor of a phenotype.\nOBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'under expressed' MI:0223. " [MI:0268]
xref_analog: MI:0268
is_obsolete: true

[Term]
id: IEV:0002687
name: suppression mutation
def: "a given (suppressed) mutation phenotype is reverted by a supressor gene mutation.\nOBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'mutated gene' MI:0804. " [MI:0262]
xref_analog: MI:0262
is_obsolete: true

[Term]
id: IEV:0002688
name: suppression knockout
def: "Knocked out gene is the suppressor of a phenotype.\nOBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'knock out' MI:0788. " [MI:0263]
xref_analog: MI:0263
is_obsolete: true

[Term]
id: IEV:0002689
name: suppression partial alteration
def: "A mutation is the partial suppressor of a mutant phenotype.\nOBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'knock down' MI:0789. " [MI:0264]
xref_analog: MI:0264
is_obsolete: true

[Term]
id: IEV:0002690
name: synthetic phenotype
def: "Two  silent mutations  show an altered phenotype when  they co-occur on the same cell.\nOBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794." [MI:0269]
xref_analog: MI:0269
is_obsolete: true

[Term]
id: IEV:0002691
name: synthetic lethal
def: "Death phenotype observed on cells carrying combination of  two independently silent  mutations.\nOBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description (lethal FBcv:0000351)" [MI:0219]
xref_analog: MI:0219
is_obsolete: true

[Term]
id: IEV:0002692
name: synthetic growth effect
def: "Two silent mutations  show  altered growth effect  when  they co-occur on the same cell. \nOBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description ( FBcv:0000427 'cell growth defective')" [MI:0273]
xref_analog: MI:0273
is_obsolete: true

[Term]
id: IEV:0002693
name: conditional synthetic lethal
def: "Two silent mutations  show a conditional synthetic lethal phenotype when  they co-occur on the same cell. \nOBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description (lethal FBcv:0000351)" [MI:0270]
xref_analog: MI:0270
is_obsolete: true

[Term]
id: IEV:0002694
name: suppression scalable
def: "Level of over/underexpression scales the 'extend' of a phenotype.\nOBSOLETE: remap to CV intraction type 'suppressive interaction' MI:0796 and genetic experimental form 'expression level alteration' MI:0803. " [MI:0267]
xref_analog: MI:0267
is_obsolete: true

[Term]
id: IEV:0002695
name: conditional synthetic lethal nutrition-sensitivity
def: "Two silent mutations  show a nutrition sensitive lethal phenotype  when  they co-occur on the same cell.\nOBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description." [MI:0600]
xref_analog: MI:0600
is_obsolete: true

[Term]
id: IEV:0002696
name: conditional synthetic lethal temperature-sensitivity
def: "Two silent mutations  show a temperature sensitive lethal phenotype  when  they co-occur on the same cell.\nOBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description (FBcv:0000310 'temperature conditional')" [MI:0271]
xref_analog: MI:0271
is_obsolete: true

[Term]
id: IEV:0002697
name: synthetic growth defect
def: "Two silent mutations  show growth defect  when  they co-occur on the same cell. \nOBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description ( FBcv:0000427 'cell growth defective')" [MI:0274]
xref_analog: MI:0274
is_obsolete: true

[Term]
id: IEV:0002698
name: synthetic growth increase
def: "Two silent mutations  show growth increase  when  they co-occur on the same cell. \nOBSOLETE: remap to CV intraction type 'synthetic interaction' MI:0794 and external CV for phenotype description ( FBcv:0000427 'cell growth defective')" [MI:0275]
xref_analog: MI:0275
is_obsolete: true

[Term]
id: IEV:0002699
name: Nervous System Malformation
def: "Structural abnormalities of the central or peripheral nervous system resulting primarily from defects of embryogenesis." [MeSH:D009421]
xref_analog: MeSH:D009421
is_a: IEV:0002701 ! Nervous System Disease

[Term]
id: IEV:0002700
name: Neural Tube Defect
def: "Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure." [MeSH:D009436]
xref_analog: MeSH:D009436
is_a: IEV:0002699 ! Nervous System Malformation

[Term]
id: IEV:0002701
name: Nervous System Disease
def: "Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle." [MeSH:D009422]
xref_analog: MeSH:D009422
is_a: IEV:0000075 ! Disease

[Term]
id: IEV:0002702
name: Spinal Dysraphism
def: "Congenital defects of closure of one or more vertebral arches, which may be associated with malformations of the spinal cord, nerve roots, congenital fibrous bands, lipomas, and congenital cysts. These malformations range from mild (e.g., SPINA BIFIDA OCCULTA) to severe, including rachischisis where there is complete failure of neural tube and spinal cord fusion, resulting in exposure of the spinal cord at the surface. Spinal dysraphism includes all forms of spina bifida. The open form is called SPINA BIFIDA CYSTICA and the closed form is SPINA BIFIDA OCCULTA." [MeSH:D016135]
xref_analog: MeSH:D016135
xref_analog: PubMed:15555669
is_a: IEV:0002700 ! Neural Tube Defect

[Term]
id: IEV:0002703
name: Phosphorylation of MKK4 by MEKK4 in cytosol
xref_analog: IMR:0100454
xref_analog: PubMed:15731347
xref_analog: UniProt:Q9Y6R4
is_a: IEV:0000227 ! Phosphorylation of MKK4/7 by MAPKKK in cytosol
relationship: part_of IEV:0002707 ! Neural tube formation

[Term]
id: IEV:0002704
name: Morphogenesis of embryonic epithelium
def: "The process by which the anatomical structures of embryonic epithelia are generated and organized. Morphogenesis pertains to the creation of form." [GO:0016331]
xref_analog: GO:0016331
is_a: IEV:0000574 ! Embryonic morphogenesis
is_a: IEV:0002706 ! Morphogenesis of an epithelium

[Term]
id: IEV:0002705
name: Embryonic epithelial tube formation
def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GO:0001838]
xref_analog: GO:0001838
is_a: IEV:0002704 ! Morphogenesis of embryonic epithelium
relationship: part_of IEV:0002711 ! Tube morphogenesis

[Term]
id: IEV:0002706
name: Morphogenesis of an epithelium
def: "The process by which the anatomical structures of epithelia are generated and organized. Morphogenesis pertains to the creation of form. An epithelium is a sheet of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GO:0002009]
xref_analog: GO:0002009
is_a: IEV:0000447 ! Anatomical structure morphogenesis

[Term]
id: IEV:0002707
name: Neural tube formation
def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GO:0001841]
exact_synonym: "neural tube morphogenesis" []
exact_synonym: "neurulation" [GO:0001841]
xref_analog: GO:0001841
is_a: IEV:0002705 ! Embryonic epithelial tube formation
relationship: part_of IEV:0002710 ! Nervous system development

[Term]
id: IEV:0002708
name: Neural tube closure
def: "The last step in the formation of the neural tube, where the paired neural folds are brought together at the dorsal midline." [GO:0001843]
xref_analog: GO:0001843
is_a: IEV:0002704 ! Morphogenesis of embryonic epithelium
relationship: part_of IEV:0002707 ! Neural tube formation

[Term]
id: IEV:0002709
name: Neural plate morphogenesis
def: "The process by which the anatomical structures of the neural plate are generated and organized. Morphogenesis pertains to the creation of form. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GO:0001839]
xref_analog: GO:0001839
is_a: IEV:0002704 ! Morphogenesis of embryonic epithelium

[Term]
id: IEV:0002710
name: Nervous system development
def: "The origin and formation of nervous tissue." [GO:0007399]
exact_synonym: "neurite formation" [GO:0007399]
exact_synonym: "neurite growth" [GO:0007399]
xref_analog: GO:0007399
is_a: IEV:0003794 ! System development

[Term]
id: IEV:0002711
name: Tube morphogenesis
def: "The process by which the anatomical structures of a tube are generated and organized. Morphogenesis pertains to the creation of form. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GO:0035239]
xref_analog: GO:0035239
is_a: IEV:0000447 ! Anatomical structure morphogenesis
relationship: part_of IEV:0002713 ! Tube development

[Term]
id: IEV:0002712
name: Organ development
def: "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GO:0048513]
exact_synonym: "development of an organ" [GO:0048513]
exact_synonym: "organogenesis" [GO:0048513]
xref_analog: GO:0048513
is_a: IEV:0003795 ! Anatomical structure development
relationship: part_of IEV:0003794 ! System development

[Term]
id: IEV:0002713
name: Tube development
def: "The process whose specific outcome is the progression of a tube over time, from its intial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [GO:0035295]
xref_analog: GO:0035295
is_a: IEV:0003795 ! Anatomical structure development
relationship: part_of IEV:0003745 ! Multicellular organismal development

[Term]
id: IEV:0002714
name: Toll-like receptor signaling pathway (through JNK cascade)
relationship: part_of IEV:0000462 ! Toll-like receptor signaling pathway

[Term]
id: IEV:0002715
name: Binding of ECSIT and MEKK1 in cytosol
xref_analog: IMR:0100222
xref_analog: IMR:0100539
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0002716
name: Binding of TRAF6 and ECSIT in cytosol
xref_analog: IMR:0100427
xref_analog: IMR:0100539
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0002717
name: Binding of cytokine receptor and Grb2 in cytosol
xref_analog: IMR:0000095
xref_analog: IMR:0000340
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0002718
name: Dephosphorylation of STAT5 by SHP-2 in cytosol
xref_analog: IMR:0000276
xref_analog: IMR:0100733
is_a: IEV:0000149 ! Dephosphorylation of STAT dimer by PTP in cytosol

[Term]
id: IEV:0002719
name: Phosphorylation of STAT3 dimer by serine kinase in cytosol and/or nucleus
xref_analog: IMR:0000223
xref_analog: IMR:0000377
is_a: IEV:0002247 ! Phosphorylation of STAT dimer by serine kinase in cytosol and/or nucleus

[Term]
id: IEV:0002720
name: nonenzymatic reaction
def: "The reaction direction shown, that is, A + B <==> C + D versus C + D <==> A + B, is in accordance with the direction of the reaction within a pathway.\nThis reaction occurs spontaneously -- no enzyme is required." [EcoCyc:]
is_a: IEV:0000221 ! Metabolic reaction

[Term]
id: IEV:0002721
name: enzymatic reaction
def: "Terms aiming to represent biochemical reactions referring to their resulting product modifications." [MI:0414]
xref_analog: MI:0414
is_a: IEV:0000221 ! Metabolic reaction

[Term]
id: IEV:0002722
name: Alcohol + NAD+ = Aldehyde + NADH + H+( EC:1.1.1.1 )
comment: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+( EC:1.1.1.1 )
xref_analog: EC:1.1.1.1
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200521
xref_analog: KEGG:C00069
xref_analog: KEGG:C00071
xref_analog: KEGG:R07326
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0002723
name: Secondary alcohol + NADP+ = Ketone + NADPH + H+( EC:1.1.1.184 )
xref_analog: EC:1.1.1.184
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200463
xref_analog: KEGG:C01450
xref_analog: KEGG:C01612
xref_analog: KEGG:R03557
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0002724
name: Alditol + NADP+ = Aldose + NADPH + H+( EC:1.1.1.21 )
xref_analog: EC:1.1.1.21
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200463
xref_analog: KEGG:C00717
xref_analog: KEGG:C01370
xref_analog: KEGG:R02820
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0002725
name: (3S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+( EC:1.1.1.35 )
xref_analog: EC:1.1.1.35
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200521
xref_analog: KEGG:C00264
xref_analog: KEGG:C00640
xref_analog: KEGG:R01778
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0002726
name: procollagen L-proline + 2-Oxo-glutaric acid + O2 = procollagen trans-4-hydroxy-L-proline + Succinic acid + CO2( EC:1.14.11.2 )
xref_analog: EC:1.14.11.2
xref_analog: IMR:0200119
xref_analog: IMR:0200217
xref_analog: IMR:0200324
xref_analog: IMR:0200480
xref_analog: KEGG:C01078
xref_analog: KEGG:C04398
xref_analog: KEGG:R03219
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0002727
name: Alkane + Reduced flavoprotein + O2 = ROH + Oxidized flavoprotein + H2O( EC:1.14.14.1 )
xref_analog: EC:1.14.14.1
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200450
xref_analog: IMR:0200519
xref_analog: KEGG:C01335
xref_analog: KEGG:C01371
xref_analog: KEGG:R04122
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0002728
name: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin( EC:1.17.4.1 )
xref_analog: EC:1.17.4.1
xref_analog: IMR:0200108
xref_analog: IMR:0200133
xref_analog: IMR:0200357
xref_analog: KEGG:C03723
xref_analog: KEGG:C04232
xref_analog: KEGG:R04294
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0002729
name: Aldehyde + NAD+ + H2O = Carboxylate + NADH + H+( EC:1.2.1.3 )
xref_analog: EC:1.2.1.3
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: IMR:0200521
xref_analog: KEGG:C00060
xref_analog: KEGG:C00071
xref_analog: KEGG:R00538
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0002730
name: Aldehyde + NADP+ + H2O = Carboxylate + NADPH + H+( EC:1.2.1.5 )
xref_analog: EC:1.2.1.5
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200357
xref_analog: IMR:0200463
xref_analog: KEGG:C00060
xref_analog: KEGG:C00071
xref_analog: KEGG:R00634
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0002731
name: Aldehyde + H2O + O2 = Carboxylate + H2O2( EC:1.2.3.1 )
xref_analog: EC:1.2.3.1
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200487
xref_analog: KEGG:C00060
xref_analog: KEGG:C00071
xref_analog: KEGG:R00635
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0002732
name: Acyl-CoA + Acceptor = 2,3-dehydroacyl-CoA + Reduced acceptor( EC:1.3.99.3 )
xref_analog: EC:1.3.99.3
xref_analog: IMR:0200065
xref_analog: IMR:0200224
xref_analog: IMR:0200300
xref_analog: KEGG:C00605
xref_analog: KEGG:R00392
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0002733
name: D-amino acid + H2O + O2 = 2-oxo acid + NH3 + H2O2( EC:1.4.3.3 )
xref_analog: EC:1.4.3.3
xref_analog: IMR:0200075
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200487
xref_analog: KEGG:C00161
xref_analog: KEGG:C00405
xref_analog: KEGG:R01340
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0002734
name: Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.4 )
xref_analog: EC:1.4.3.4
xref_analog: IMR:0200075
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200487
xref_analog: KEGG:C00071
xref_analog: KEGG:C00375
xref_analog: KEGG:R01853
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0002735
name: Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.21 )
xref_analog: EC:1.4.3.21
xref_analog: IMR:0200075
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200487
xref_analog: KEGG:C00071
xref_analog: KEGG:C00375
xref_analog: KEGG:R01853
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0002736
name: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+( EC:1.8.1.4 )
xref_analog: EC:1.8.1.4
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200521
xref_analog: KEGG:C16237
xref_analog: KEGG:C16832
xref_analog: KEGG:R08550
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0002737
name: S-adenosyl-L-methionine + Amine = S-adenosyl-L-homocysteine + Methylated amine( EC:2.1.1.49 )
xref_analog: EC:2.1.1.49
xref_analog: IMR:0200054
xref_analog: IMR:0200151
xref_analog: KEGG:C00706
xref_analog: KEGG:C02436
xref_analog: KEGG:R02808
is_a: IEV:0000433 ! Transmethylation

[Term]
id: IEV:0002739
name: Acyl-CoA + Acetyl-CoA = CoA + 3-Oxoacyl-CoA( EC:2.3.1.16 )
xref_analog: EC:2.3.1.16
xref_analog: IMR:0200065
xref_analog: IMR:0200354
xref_analog: IMR:0200414
xref_analog: KEGG:C00264
xref_analog: KEGG:R00391
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0002741
name: (5-L-glutamyl)-peptide + Amino acid = peptide + 5-L-glutamyl amino acid( EC:2.3.2.2 )
xref_analog: EC:2.3.2.2
xref_analog: IMR:0001695
xref_analog: KEGG:C00012
xref_analog: KEGG:C03193
xref_analog: KEGG:C03363
xref_analog: KEGG:R04159
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0002742
name: purine nucleoside + Orthophosphate = purine + D-ribose 1-phosphate( EC:2.4.2.1 )
comment: general reaction
xref_analog: EC:2.4.2.1
xref_analog: IMR:0200102
xref_analog: KEGG:C00620
xref_analog: KEGG:C15586
xref_analog: KEGG:C15587
xref_analog: KEGG:R08368
is_a: IEV:0002560 ! Glycosylation

[Term]
id: IEV:0002743
name: Phosphoenol-pyruvic acid + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + Orthophosphate( EC:2.5.1.57 )
xref_analog: EC:2.5.1.57
xref_analog: IMR:0200102
xref_analog: IMR:0200223
xref_analog: IMR:0200357
xref_analog: KEGG:C00686
xref_analog: KEGG:C01200
xref_analog: KEGG:R02769
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0002744
name: ATP + D-hexose = ADP + D-hexose 6-phosphate( EC:2.7.1.1 )
xref_analog: EC:2.7.1.1
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: KEGG:C00738
xref_analog: KEGG:C02965
xref_analog: KEGG:R02848
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0002745
name: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate( EC:2.7.1.60 )
xref_analog: EC:2.7.1.60
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: KEGG:C00625
xref_analog: KEGG:C00686
xref_analog: KEGG:R02650
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0002746
name: Nucleoside triphosphate + deoxycytidine = Nucleoside diphosphate + dCMP( EC:2.7.1.74 )
xref_analog: EC:2.7.1.74
xref_analog: IMR:0200005
xref_analog: IMR:0200390
xref_analog: IMR:0200499
xref_analog: KEGG:C00454
xref_analog: KEGG:R02321
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0002747
name: Nucleoside triphosphate + AMP = Nucleoside diphosphate + ADP( EC:2.7.4.10 )
xref_analog: EC:2.7.4.10
xref_analog: IMR:0001360
xref_analog: IMR:0200083
xref_analog: IMR:0200499
xref_analog: KEGG:C00454
xref_analog: KEGG:R00333
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0002748
name: CTP + N-acylneuraminate = Pyrophosphate + CMP-N-acylneuraminate( EC:2.7.7.43 )
xref_analog: EC:2.7.7.43
xref_analog: IMR:0200202
xref_analog: IMR:0200280
xref_analog: KEGG:C00591
xref_analog: KEGG:C01064
xref_analog: KEGG:R02599
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0002749
name: Succinyl-CoA + 3-oxo acid = succinate + 3-oxoacyl-CoA( EC:2.8.3.5 )
xref_analog: EC:2.8.3.5
xref_analog: IMR:0200037
xref_analog: IMR:0200119
xref_analog: KEGG:C00264
xref_analog: KEGG:C01656
xref_analog: KEGG:R01780
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0002750
name: myo-inositol phosphate + H2O = myo-inositol + Orthophosphate( EC:3.1.3.25 )
xref_analog: EC:3.1.3.25
xref_analog: IMR:0200102
xref_analog: IMR:0200177
xref_analog: IMR:0200357
xref_analog: KEGG:C15585
xref_analog: KEGG:R07343
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0002751
name: 5'-ribonucleotide + H2O = ribonucleoside + phosphate( EC:3.1.3.5 )
xref_analog: EC:3.1.3.5
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: KEGG:C00911
xref_analog: KEGG:C02520
xref_analog: KEGG:R07297
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0002752
name: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate( EC:3.1.4.17 )
xref_analog: EC:3.1.4.17
xref_analog: IMR:0200357
xref_analog: KEGG:C01117
xref_analog: KEGG:C04212
xref_analog: KEGG:R03259
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0002753
name: Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides( EC:3.2.1.23 )
xref_analog: EC:3.2.1.23
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0002754
name: N-acyl-L-aspartate + H2O = Carboxylate + L-Aspartic acid( EC:3.5.1.15 )
xref_analog: EC:3.5.1.15
xref_analog: IMR:0200357
xref_analog: IMR:0200459
xref_analog: KEGG:C00060
xref_analog: KEGG:C02715
xref_analog: KEGG:R00546
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0002755
name: Nucleoside triphosphate + H2O = Nucleotide + diphosphate( EC:3.6.1.19 )
xref_analog: EC:3.6.1.19
xref_analog: IMR:0001349
xref_analog: IMR:0200280
xref_analog: IMR:0200357
xref_analog: IMR:0200499
xref_analog: KEGG:R01532
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0002756
name: nucleoside diphosphate + H2O = nucleotide + Orthophosphate( EC:3.6.1.6 )
xref_analog: EC:3.6.1.6
xref_analog: IMR:0001349
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: KEGG:C00454
xref_analog: KEGG:R00329
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0002757
name: Acylphosphate + H2O = Carboxylate + phosphate( EC:3.6.1.7 )
xref_analog: EC:3.6.1.7
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: KEGG:C00060
xref_analog: KEGG:C02133
xref_analog: KEGG:R00539
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0002758
name: dinucleotide + H2O = 2 mononucleotide( EC:3.6.1.9 )
xref_analog: EC:3.6.1.9
xref_analog: IMR:0200357
xref_analog: KEGG:C01910
xref_analog: KEGG:C02171
xref_analog: KEGG:R00056
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0002759
name: (3S)-3-hydroxyacyl-CoA = trans-2,3-Dehydroacyl-CoA + H2O( EC:4.2.1.17 )
xref_analog: EC:4.2.1.17
xref_analog: IMR:0200357
xref_analog: KEGG:C00640
xref_analog: KEGG:C00658
xref_analog: KEGG:R02685
is_a: IEV:0000917 ! Lyase process

[Term]
id: IEV:0002760
name: N-acyl-D-glucosamine = N-acyl-D-mannosamine( EC:5.1.3.8 )
xref_analog: EC:5.1.3.8
xref_analog: KEGG:C00625
xref_analog: KEGG:C03000
xref_analog: KEGG:R02652
is_a: IEV:0000915 ! Isomerization

[Term]
id: IEV:0002761
name: Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine( EC:3.4.13.20 )
xref_analog: EC:3.4.13.20
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0002762
name: Pyruvic acid + Enzyme N6-(lipoyl)lysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2( EC:1.2.4.1 )
comment: pyruvate + [dihydrolipoyllysine-residue acetyltransferase]lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2( EC:1.2.4.1 )
xref_analog: EC:1.2.4.1
xref_analog: IMR:0200324
xref_analog: IMR:0200331
xref_analog: KEGG:C15972
xref_analog: KEGG:C16255
xref_analog: KEGG:R01699
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001424 ! Pyruvate metabolism

[Term]
id: IEV:0002763
name: 2-Oxo-glutaric acid + Enzyme N6-(lipoyl)lysine = [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2( EC:1.2.4.2 )
comment: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2( EC:1.2.4.2 )
xref_analog: EC:1.2.4.2
xref_analog: IMR:0200324
xref_analog: IMR:0200480
xref_analog: KEGG:C15972
xref_analog: KEGG:C16254
xref_analog: KEGG:R01700
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001415 ! Citrate cycle (TCA cycle)

[Term]
id: IEV:0002764
name: ATP + Uridine => ADP + UMP( EC:2.7.1.48 )
xref_analog: EC:2.7.1.48
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200021
xref_analog: IMR:0200409
xref_analog: KEGG:map00240
xref_analog: KEGG:R00964
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002765
name: ATP + D-Ribose 5-phosphate = AMP + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.7.6.1 )
comment: ATP + D-Ribose 5-phosphate = AMP + D-5-Phospho-ribosyl 1-diphosphate( EC:2.7.6.1 )
xref_analog: EC:2.7.6.1
xref_analog: IMR:0001351
xref_analog: IMR:0200060
xref_analog: IMR:0200083
xref_analog: IMR:0200179
xref_analog: KEGG:map00030
xref_analog: KEGG:map00230
xref_analog: KEGG:R01049
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001414 ! Pentose phosphate pathway
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002766
name: 2-Oxo-glutaric acid + beta-Alanine = L-Glutamic acid + Malonate semialdehyde( EC:2.6.1.19 )
xref_analog: EC:2.6.1.19
xref_analog: IMR:0100119
xref_analog: IMR:0200438
xref_analog: IMR:0200480
xref_analog: IMR:0200520
xref_analog: KEGG:map00410
xref_analog: KEGG:map00640
xref_analog: KEGG:R00908
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001426 ! Propanoate metabolism

[Term]
id: IEV:0002767
name: L-Arginine + Glycine = L-Ornithine + Guanidino-acetic acid( EC:2.1.4.1 )
xref_analog: EC:2.1.4.1
xref_analog: IMR:0100118
xref_analog: IMR:0200342
xref_analog: IMR:0200413
xref_analog: IMR:0200428
xref_analog: KEGG:map00260
xref_analog: KEGG:map00330
xref_analog: KEGG:R00565
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0002768
name: L-Arginino-succinic acid = L-Arginine + Fumaric acid( EC:4.3.2.1 )
xref_analog: EC:4.3.2.1
xref_analog: IMR:0200186
xref_analog: IMR:0200391
xref_analog: IMR:0200428
xref_analog: KEGG:map00250
xref_analog: KEGG:map00330
xref_analog: KEGG:R01086
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001410 ! Alanine and aspartate metabolism
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0002769
name: ATP + D-Ribose => ADP + D-Ribose 5-phosphate( EC:2.7.1.15 )
xref_analog: EC:2.7.1.15
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200060
xref_analog: IMR:0200130
xref_analog: KEGG:map00030
xref_analog: KEGG:R01051
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001414 ! Pentose phosphate pathway

[Term]
id: IEV:0002770
name: NAD+ + D-Sorbitol = NADH + D-Fructose + H+( EC:1.1.1.14 )
comment: NAD+ + D-Sorbitol = NADH + D-Fructose( EC:1.1.1.14 )
xref_analog: EC:1.1.1.14
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200462
xref_analog: IMR:0200474
xref_analog: IMR:0200521
xref_analog: KEGG:map00051
xref_analog: KEGG:R00875
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001417 ! Fructose and mannose metabolism

[Term]
id: IEV:0002771
name: 2 Farnesyl diphosphate => Presqualene diphosphate + Pyrophosphate( EC:2.5.1.21 )
comment: subsequently IEV:0003222
xref_analog: EC:2.5.1.21
xref_analog: IMR:0200097
xref_analog: IMR:0200273
xref_analog: IMR:0200280
xref_analog: KEGG:map00100
xref_analog: KEGG:R00702
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0003169 ! 2 Farnesyl diphosphate + NADPH + H+ => NADP+ + Squalene + 2 Pyrophosphate( EC:2.5.1.21 )

[Term]
id: IEV:0002772
name: Deoxy-uridine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Uracil( EC:2.4.2.4 )
xref_analog: EC:2.4.2.4
xref_analog: IMR:0200048
xref_analog: IMR:0200102
xref_analog: IMR:0200103
xref_analog: IMR:0200234
xref_analog: KEGG:map00240
xref_analog: KEGG:R02484
is_a: IEV:0002560 ! Glycosylation
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002773
name: NADPH + Leukotriene B4 + O2 + H+ => NADP+ + 20-OH-Leukotriene B4 + H2O( EC:1.14.13.30 )
comment: NADPH + Leucotriene B4 + O2 => NADP+ + 20-OH-Leukotriene B4 + H2O( EC:1.14.13.30 )
xref_analog: EC:1.14.13.30
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200217
xref_analog: IMR:0200323
xref_analog: IMR:0200357
xref_analog: IMR:0200376
xref_analog: IMR:0200463
xref_analog: KEGG:map00590
xref_analog: KEGG:R03866
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001449 ! Arachidonic acid metabolism

[Term]
id: IEV:0002774
name: NAD+ + (R)-Lactic acid = NADH + Pyruvic acid + H+( EC:1.1.1.28 )
comment: NAD+ + (R)-Lactic acid = NADH + Pyruvic acid( EC:1.1.1.28 )
xref_analog: EC:1.1.1.28
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200313
xref_analog: IMR:0200331
xref_analog: IMR:0200521
xref_analog: KEGG:map00620
xref_analog: KEGG:R00704
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001424 ! Pyruvate metabolism

[Term]
id: IEV:0002775
name: Propanoyl-CoA + Electron-transferring flavoprotein = Propenoyl-CoA + Reduced electron-transferring flavoprotein( EC:1.3.99.3 )
comment: Propanoyl-CoA + Acceptor = Propenoyl-CoA + Reduced acceptor( EC:1.3.99.3 )
xref_analog: EC:1.3.99.3
xref_analog: IMR:0200441
xref_analog: IMR:0200484
xref_analog: KEGG:C04253
xref_analog: KEGG:C04570
xref_analog: KEGG:map00640
xref_analog: KEGG:R04432
is_a: IEV:0002732 ! Acyl-CoA + Acceptor = 2,3-dehydroacyl-CoA + Reduced acceptor( EC:1.3.99.3 )
relationship: part_of IEV:0001426 ! Propanoate metabolism

[Term]
id: IEV:0002776
name: ATP + dGDP = ADP + dGTP( EC:2.7.4.6 )
xref_analog: EC:2.7.4.6
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200286
xref_analog: IMR:0200365
xref_analog: KEGG:map00230
xref_analog: KEGG:R01857
is_a: IEV:0002907 ! ATP + Nucleoside diphosphate = ADP + Nucleoside triphosphate( EC:2.7.4.6 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002777
name: D-Mannose 6-phosphate = beta-D-Fructose 6-phosphate( EC:5.3.1.8 )
comment: D-Mannose 6-phosphate = D-Fructose 6-phosphate( EC:5.3.1.8 )
xref_analog: EC:5.3.1.8
xref_analog: IMR:0200053
xref_analog: KEGG:C05345
xref_analog: KEGG:map00051
xref_analog: KEGG:map00520
xref_analog: KEGG:R01819
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001417 ! Fructose and mannose metabolism

[Term]
id: IEV:0002778
name: NADP+ + 10-Formyl-tetrahydro-folic acid + H2O => NADPH + Tetrahydrofolate + CO2 + H+( EC:1.5.1.6 )
comment: NADP+ + 10-Formyl-tetrahydro-folic acid + H2O => NADPH + L-Tetrahydro-folic acid + CO2( EC:1.5.1.6 )
xref_analog: EC:1.5.1.6
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200324
xref_analog: IMR:0200330
xref_analog: IMR:0200347
xref_analog: IMR:0200357
xref_analog: IMR:0200463
xref_analog: KEGG:map00670
xref_analog: KEGG:R00941
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0002779
name: NAD+ + N4-Acetylaminobutanal + H2O => NADH + N4-Acetyl-amino-butanoic acid + H+( EC:1.2.1.3 )
comment: NAD+ + N4-Acetyl-amino-butyraldehyde + H2O => NADH + N4-Acetyl-amino-butanoic acid( EC:1.2.1.3 )
xref_analog: EC:1.2.1.3
xref_analog: IMR:0002041
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: IMR:0200421
xref_analog: IMR:0200521
xref_analog: KEGG:map00330
xref_analog: KEGG:R05050
is_a: IEV:0002729 ! Aldehyde + NAD+ + H2O = Carboxylate + NADH + H+( EC:1.2.1.3 )
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0002780
name: dGMP + H2O => Deoxy-guanosine + Orthophosphate( EC:3.1.3.5 )
xref_analog: EC:3.1.3.5
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: IMR:0200495
xref_analog: IMR:0200505
xref_analog: KEGG:map00230
xref_analog: KEGG:R01968
is_a: IEV:0002751 ! 5'-ribonucleotide + H2O = ribonucleoside + phosphate( EC:3.1.3.5 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002781
name: ATP + 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate => ADP + 1-Phosphatidyl-1D-myo-inositol 3,4,5-triphosphate( EC:2.7.1.153 )
xref_analog: EC:2.7.1.153
xref_analog: IMR:0001350
xref_analog: IMR:0001351
xref_analog: IMR:0001352
xref_analog: IMR:0001360
xref_analog: KEGG:map00562
xref_analog: KEGG:map04070
xref_analog: KEGG:R04545
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0002782
name: S-Adenosyl-L-methionine + L-Adrenaline => S-Adenosyl-L-homocysteine + L-Metanephrine( EC:2.1.1.6 )
xref_analog: EC:2.1.1.6
xref_analog: IMR:0100114
xref_analog: IMR:0200054
xref_analog: IMR:0200080
xref_analog: IMR:0200151
xref_analog: KEGG:map00350
xref_analog: KEGG:R02920
is_a: IEV:0000433 ! Transmethylation
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0002783
name: ATP + Propanoyl-CoA + HCO3- => ADP + (S)-Methyl-malonyl-CoA + Orthophosphate( EC:6.4.1.3 )
comment: ATP + Propanoyl-CoA + CO2 + H2O => ADP + (S)-Methyl-malonyl-CoA + Orthophosphate( EC:6.4.1.3 )
xref_analog: EC:6.4.1.3
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200016
xref_analog: IMR:0200102
xref_analog: IMR:0200484
xref_analog: KEGG:C00288
xref_analog: KEGG:map00280
xref_analog: KEGG:map00640
xref_analog: KEGG:R01859
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001426 ! Propanoate metabolism

[Term]
id: IEV:0002784
name: 2-Oxo-glutaric acid + L-Cysteine-sulfinic acid = L-Glutamic acid + 3-Sulfinyl-pyruvic acid( EC:2.6.1.1 )
xref_analog: EC:2.6.1.1
xref_analog: IMR:0100119
xref_analog: IMR:0200170
xref_analog: IMR:0200402
xref_analog: IMR:0200480
xref_analog: KEGG:map00270
xref_analog: KEGG:R02619
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001466 ! Methionine and Cysteine metabolism

[Term]
id: IEV:0002786
name: ATP + UDP = ADP + UTP( EC:2.7.4.6 )
xref_analog: EC:2.7.4.6
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200199
xref_analog: IMR:0200206
xref_analog: KEGG:map00240
xref_analog: KEGG:R00156
is_a: IEV:0002907 ! ATP + Nucleoside diphosphate = ADP + Nucleoside triphosphate( EC:2.7.4.6 )
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002787
name: Acetyl-CoA + Enzyme N6-(dihydrolipoyl)lysine = CoA + S-acetyldihydrolipoyllysine( EC:2.3.1.12 )
alt_id: IEV:0003313
comment: Acetyl-CoA + Dihydro-lipoamide = CoA + 6-S-Acetyl-dihydro-lipoamide( EC:2.3.1.12 )
exact_synonym: "Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine( EC:2.3.1.12 )" []
xref_analog: EC:2.3.1.12
xref_analog: IMR:0200354
xref_analog: IMR:0200414
xref_analog: KEGG:C15973
xref_analog: KEGG:C16255
xref_analog: KEGG:map00010
xref_analog: KEGG:map00020
xref_analog: KEGG:map00620
xref_analog: KEGG:R02569
is_a: IEV:0002399 ! Transacetylation
relationship: part_of IEV:0001424 ! Pyruvate metabolism

[Term]
id: IEV:0002788
name: L-Kynurenine + H2O => Anthranilic acid + L-Alanine( EC:3.7.1.3 )
xref_analog: EC:3.7.1.3
xref_analog: IMR:0200251
xref_analog: IMR:0200301
xref_analog: IMR:0200312
xref_analog: IMR:0200357
xref_analog: KEGG:map00380
xref_analog: KEGG:R00987
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0002789
name: ATP + 1-Phosphatidyl-1D-myo-inositol => ADP + 1-Phosphatidyl-1D-myo-inositol 4-phosphate( EC:2.7.1.67 )
xref_analog: EC:2.7.1.67
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200469
xref_analog: IMR:0200496
xref_analog: KEGG:map00562
xref_analog: KEGG:map04070
xref_analog: KEGG:R03361
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0002790
name: Phenyl-ethylamine + H2O + O2 => Phenyl-acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
xref_analog: EC:1.4.3.4
xref_analog: IMR:0200075
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200418
xref_analog: IMR:0200487
xref_analog: IMR:0200516
xref_analog: KEGG:map00360
xref_analog: KEGG:R02613
is_a: IEV:0002734 ! Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.4 )
relationship: part_of IEV:0001461 ! Phenylalanine metabolism

[Term]
id: IEV:0002791
name: Orotidine 5'-phosphate + Pyrophosphate = Orotic acid + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.10 )
comment: 5'-Orotidylic acid + Pyrophosphate = Orotic acid + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.10 )
xref_analog: EC:2.4.2.10
xref_analog: IMR:0200087
xref_analog: IMR:0200179
xref_analog: IMR:0200265
xref_analog: IMR:0200280
xref_analog: KEGG:map00240
xref_analog: KEGG:R01870
is_a: IEV:0002560 ! Glycosylation
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002792
name: NADP+ + (S)-Malic acid = NADPH + Pyruvic acid + CO2 + H+( EC:1.1.1.40 )
comment: NAD+ + (S)-Malic acid = NADH + Pyruvic acid + CO2( EC:1.1.1.40 )
xref_analog: EC:1.1.1.40
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200278
xref_analog: IMR:0200324
xref_analog: IMR:0200331
xref_analog: IMR:0200463
xref_analog: KEGG:map00620
xref_analog: KEGG:map00710
xref_analog: KEGG:R00216
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001424 ! Pyruvate metabolism

[Term]
id: IEV:0002793
name: NAD+ + Phenyl-acetaldehyde + H2O = NADH + Phenyl-acetic acid + H+( EC:1.2.1.5 )
comment: NAD+ + Phenyl-acetaldehyde + H2O = NADH + Phenyl-acetic acid( EC:1.2.1.5 )
xref_analog: EC:1.2.1.5
xref_analog: IMR:0200030
xref_analog: IMR:0200193
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: IMR:0200418
xref_analog: IMR:0200521
xref_analog: KEGG:map00360
xref_analog: KEGG:map00643
xref_analog: KEGG:R02536
is_a: IEV:0002730 ! Aldehyde + NADP+ + H2O = Carboxylate + NADPH + H+( EC:1.2.1.5 )
relationship: part_of IEV:0001461 ! Phenylalanine metabolism

[Term]
id: IEV:0002794
name: ATP + 1D-myo-inositol 1,4,5-trisphosphate => ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate( EC:2.7.1.151 )
xref_analog: EC:2.7.1.151
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0100028
xref_analog: IMR:0200243
xref_analog: KEGG:map00562
xref_analog: KEGG:R05800
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0002795
name: Succinyl-CoA + Acetoacetic acid = Succinic acid + Acetoacetyl-CoA( EC:2.8.3.5 )
xref_analog: EC:2.8.3.5
xref_analog: IMR:0200037
xref_analog: IMR:0200064
xref_analog: IMR:0200119
xref_analog: IMR:0200410
xref_analog: KEGG:map00072
xref_analog: KEGG:map00280
xref_analog: KEGG:map00650
xref_analog: KEGG:R00410
is_a: IEV:0002749 ! Succinyl-CoA + 3-oxo acid = succinate + 3-oxoacyl-CoA( EC:2.8.3.5 )
relationship: part_of IEV:0001427 ! Butanoate metabolism
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0002796
name: Tetrahydrofolate + L-Serine = 5,10-Methylene-tetrahydro-folic acid + Glycine + H2O( EC:2.1.2.1 )
comment: L-Tetrahydro-folic acid + L-Serine = 5,10-Methylene-tetrahydro-folic acid + Glycine + H2O( EC:2.1.2.1 )
xref_analog: EC:2.1.2.1
xref_analog: IMR:0100118
xref_analog: IMR:0200330
xref_analog: IMR:0200357
xref_analog: IMR:0200453
xref_analog: IMR:0200517
xref_analog: KEGG:map00260
xref_analog: KEGG:map00670
xref_analog: KEGG:R00945
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0002797
name: XTP + H2O => XMP + Pyrophosphate( EC:3.6.1.19 )
xref_analog: EC:3.6.1.19
xref_analog: IMR:0200165
xref_analog: IMR:0200280
xref_analog: IMR:0200357
xref_analog: IMR:0200425
xref_analog: KEGG:map00230
xref_analog: KEGG:R02720
is_a: IEV:0002755 ! Nucleoside triphosphate + H2O = Nucleotide + diphosphate( EC:3.6.1.19 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002798
name: 10-Formyl-tetrahydro-folic acid + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide => Tetrahydrofolate + 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide( EC:2.1.2.3 )
comment: 10-Formyl-tetrahydro-folic acid + 5'-Phospho-ribosyl-4-carboxamido-5-amino-imidazole => L-Tetrahydro-folic acid + 5'-Phospho-ribosyl-4-carboxamido-5-formamido-imidazole( EC:2.1.2.3 )
xref_analog: EC:2.1.2.3
xref_analog: IMR:0200284
xref_analog: IMR:0200330
xref_analog: IMR:0200347
xref_analog: IMR:0200452
xref_analog: KEGG:map00230
xref_analog: KEGG:map00670
xref_analog: KEGG:R04560
is_a: IEV:0002674 ! Formylation
relationship: part_of IEV:0001450 ! Purine metabolism
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0002799
name: NAD+ + Dihydro-lipoylprotein = NADH + Lipoylprotein + H+( EC:1.8.1.4 )
comment: NAD+ + Dihydro-lipoylprotein = NADH + Lipoylprotein( EC:1.8.1.4 )
xref_analog: EC:1.8.1.4
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200336
xref_analog: IMR:0200367
xref_analog: IMR:0200521
xref_analog: KEGG:map00260
xref_analog: KEGG:R03815
is_a: IEV:0002736 ! protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+( EC:1.8.1.4 )
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism

[Term]
id: IEV:0002800
name: ATP + Pyruvic acid + HCO3- = ADP + Oxaloacetic acid + Orthophosphate( EC:6.4.1.1 )
comment: ATP + Pyruvic acid + CO2 + H2O = ADP + Oxaloacetic acid + Orthophosphate( EC:6.4.1.1 )
xref_analog: EC:6.4.1.1
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200102
xref_analog: IMR:0200331
xref_analog: IMR:0200339
xref_analog: KEGG:C00288
xref_analog: KEGG:map00020
xref_analog: KEGG:map00620
xref_analog: KEGG:R00344
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001415 ! Citrate cycle (TCA cycle)

[Term]
id: IEV:0002801
name: Citric acid = cis-Aconitic acid + H2O( EC:4.2.1.3 )
xref_analog: EC:4.2.1.3
xref_analog: IMR:0200271
xref_analog: IMR:0200357
xref_analog: IMR:0200473
xref_analog: KEGG:map00020
xref_analog: KEGG:map00630
xref_analog: KEGG:map00720
xref_analog: KEGG:R01325
relationship: part_of IEV:0003326 ! Citric acid = Isocitric acid( EC:4.2.1.3 )

[Term]
id: IEV:0002802
name: D-Glucosamine 6-phosphate + H2O = D-Fructose 6-phosphate + NH3( EC:3.5.99.6 )
xref_analog: EC:3.5.99.6
xref_analog: IMR:0200075
xref_analog: IMR:0200228
xref_analog: IMR:0200261
xref_analog: IMR:0200357
xref_analog: KEGG:map00520
xref_analog: KEGG:R00765
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001421 ! Aminosugars metabolism

[Term]
id: IEV:0002803
name: Hydroxy-methylbilane => Uroporphyrinogen III + H2O( EC:4.2.1.75 )
xref_analog: EC:4.2.1.75
xref_analog: IMR:0200002
xref_analog: IMR:0200315
xref_analog: IMR:0200357
xref_analog: KEGG:map00860
xref_analog: KEGG:R03165
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001516 ! Porphyrin and chlorophyll metabolism

[Term]
id: IEV:0002804
name: TPP + 2-Oxo-glutaric acid = 3-Carboxy-1-hydroxypropyl-ThPP + CO2( EC:1.2.4.2 )
comment: subsequently IEV:0003057
xref_analog: EC:1.2.4.2
xref_analog: IMR:0002042
xref_analog: IMR:0200324
xref_analog: IMR:0200378
xref_analog: IMR:0200480
xref_analog: KEGG:map00020
xref_analog: KEGG:R00621
relationship: part_of IEV:0002763 ! 2-Oxo-glutaric acid + Enzyme N6-(lipoyl)lysine = [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2( EC:1.2.4.2 )

[Term]
id: IEV:0002805
name: S-Adenosyl-L-methionine + 3,4-Dihydroxy-phenyl-acetic acid => S-Adenosyl-L-homocysteine + Homovanillic acid( EC:2.1.1.6 )
xref_analog: EC:2.1.1.6
xref_analog: IMR:0200026
xref_analog: IMR:0200054
xref_analog: IMR:0200151
xref_analog: IMR:0200269
xref_analog: KEGG:map00350
xref_analog: KEGG:R03304
is_a: IEV:0000433 ! Transmethylation
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0002806
name: ATP + D-Glycerate 3-phosphate = ADP + 1,3-Bisphospho-D-glyceric acid( EC:2.7.2.3 )
xref_analog: EC:2.7.2.3
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200320
xref_analog: IMR:0200362
xref_analog: KEGG:map00010
xref_analog: KEGG:map00710
xref_analog: KEGG:R01512
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001413 ! Glycolysis and Gluconeogenesis

[Term]
id: IEV:0002807
name: L-Aspartic acid + Carbamoyl phosphate => N-Carbamoyl-L-aspartic acid + Orthophosphate( EC:2.1.3.2 )
xref_analog: EC:2.1.3.2
xref_analog: IMR:0200077
xref_analog: IMR:0200102
xref_analog: IMR:0200109
xref_analog: IMR:0200459
xref_analog: KEGG:map00240
xref_analog: KEGG:map00250
xref_analog: KEGG:R01397
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001410 ! Alanine and aspartate metabolism
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002808
name: Prostaglandin H2 = Prostaglandin I2( EC:5.3.99.4 )
xref_analog: EC:5.3.99.4
xref_analog: IMR:0200253
xref_analog: IMR:0200281
xref_analog: KEGG:map00590
xref_analog: KEGG:R02267
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001449 ! Arachidonic acid metabolism

[Term]
id: IEV:0002809
name: NADP+ + 5,6-Dihydro-uracil = NADPH + Uracil + H+( EC:1.3.1.2 )
comment: NADP+ + 5,6-Dihydro-uracil = NADPH + Uracil( EC:1.3.1.2 )
xref_analog: EC:1.3.1.2
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200234
xref_analog: IMR:0200363
xref_analog: IMR:0200463
xref_analog: KEGG:map00240
xref_analog: KEGG:R00978
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002811
name: Nicotinamide D-ribonucleotide + ATP = NAD+ + Pyrophosphate( EC:2.7.7.1 )
xref_analog: EC:2.7.7.1
xref_analog: IMR:0001351
xref_analog: IMR:0200166
xref_analog: IMR:0200248
xref_analog: IMR:0200280
xref_analog: KEGG:map00760
xref_analog: KEGG:R00137
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001510 ! Nicotinate and nicotinamide metabolism

[Term]
id: IEV:0002812
name: Pyridoxine + O2 => Pyridoxal + H2O2( EC:1.4.3.5 )
xref_analog: EC:1.4.3.5
xref_analog: IMR:0200217
xref_analog: IMR:0200344
xref_analog: IMR:0200487
xref_analog: IMR:0200504
xref_analog: KEGG:map00750
xref_analog: KEGG:R01711
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001509 ! Vitamin B6 metabolism

[Term]
id: IEV:0002813
name: NAD+ + 3,4-Dihydroxy-phenyl-ethyleneglycol = NADH + 3,4-Dihydroxy-mandelaldehyde + H+( EC:1.1.1.1 )
comment: NAD+ + 3,4-Dihydroxy-phenyl-ethyleneglycol = NADH + 3,4-Dihydroxy-mandelaldehyde( EC:1.1.1.1 )
xref_analog: EC:1.1.1.1
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200289
xref_analog: IMR:0200442
xref_analog: IMR:0200521
xref_analog: KEGG:map00350
xref_analog: KEGG:R04880
is_a: IEV:0002722 ! Alcohol + NAD+ = Aldehyde + NADH + H+( EC:1.1.1.1 )
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0002814
name: ATP + IDP = ADP + ITP( EC:2.7.4.6 )
xref_analog: EC:2.7.4.6
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200074
xref_analog: IMR:0200511
xref_analog: KEGG:map00230
xref_analog: KEGG:R00722
is_a: IEV:0002907 ! ATP + Nucleoside diphosphate = ADP + Nucleoside triphosphate( EC:2.7.4.6 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002815
name: NAD+ + 4-Amino-butyraldehyde + H2O => NADH + 4-Amino-butanoic acid + H+( EC:1.2.1.19 )
comment: NAD+ + 4-Amino-butyraldehyde + H2O => NADH + 4-Amino-butanoic acid( EC:1.2.1.19 )
xref_analog: EC:1.2.1.19
xref_analog: IMR:0100117
xref_analog: IMR:0200030
xref_analog: IMR:0200142
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: IMR:0200521
xref_analog: KEGG:map00330
xref_analog: KEGG:map00410
xref_analog: KEGG:R02549
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001458 ! Arginine and proline metabolism
relationship: part_of IEV:0001465 ! beta-Alanine metabolism

[Term]
id: IEV:0002816
name: 5-Formimino-tetrahydro-folic acid + L-Glutamic acid = Tetrahydrofolate + N-Formimino-L-glutamic acid( EC:2.1.2.5 )
comment: 5-Formimino-tetrahydro-folic acid + L-Glutamic acid = L-Tetrahydro-folic acid + N-Formimino-L-glutamic acid( EC:2.1.2.5 )
xref_analog: EC:2.1.2.5
xref_analog: IMR:0100119
xref_analog: IMR:0200211
xref_analog: IMR:0200330
xref_analog: IMR:0200443
xref_analog: KEGG:map00340
xref_analog: KEGG:map00670
xref_analog: KEGG:R02287
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001459 ! Histidine metabolism
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0002817
name: L-2-Amino-adipic acid + 2-Oxo-glutaric acid = 2-Oxo-adipic acid + L-Glutamic acid( EC:2.6.1.39 )
xref_analog: EC:2.6.1.39
xref_analog: IMR:0100119
xref_analog: IMR:0200011
xref_analog: IMR:0200322
xref_analog: IMR:0200480
xref_analog: KEGG:map00300
xref_analog: KEGG:map00310
xref_analog: KEGG:R01939
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001457 ! Lysine degradation

[Term]
id: IEV:0002818
name: NAD+ + Succinate semialdehyde + H2O = NADH + Succinic acid + H+( EC:1.2.1.24 )
comment: NAD+ + Succinate semialdehyde + H2O = NADH + Succinic acid( EC:1.2.1.24 )
xref_analog: EC:1.2.1.24
xref_analog: IMR:0200030
xref_analog: IMR:0200119
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: IMR:0200454
xref_analog: IMR:0200521
xref_analog: KEGG:map00250
xref_analog: KEGG:map00350
xref_analog: KEGG:map00650
xref_analog: KEGG:R00713
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001411 ! Glutamate metabolism

[Term]
id: IEV:0002819
name: L-Glutamate 5-semialdehyde => (S)-1-Pyrroline-5-carboxylic acid + H2O( nonenzymatic )
comment: subsequently IEV:0003288
xref_analog: IMR:0200205
xref_analog: IMR:0200236
xref_analog: IMR:0200357
xref_analog: KEGG:map00330
xref_analog: KEGG:R03314
is_a: IEV:0002720 ! nonenzymatic reaction
relationship: part_of IEV:0003199 ! NAD+ + (S)-1-Pyrroline-5-carboxylic acid + 2 H2O => NADH + L-Glutamic acid + H+( EC:1.5.1.12 )

[Term]
id: IEV:0002820
name: (S)-Malic acid = Fumaric acid + H2O( EC:4.2.1.2 )
xref_analog: EC:4.2.1.2
xref_analog: IMR:0200186
xref_analog: IMR:0200278
xref_analog: IMR:0200357
xref_analog: KEGG:map00020
xref_analog: KEGG:map00720
xref_analog: KEGG:R01082
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001415 ! Citrate cycle (TCA cycle)

[Term]
id: IEV:0002821
name: NAD+ + (R)-3-Hydroxy-butanoic acid = NADH + Acetoacetic acid + H+( EC:1.1.1.30 )
comment: NAD+ + (R)-3-Hydroxy-butanoic acid = NADH + Acetoacetic acid( EC:1.1.1.30 )
xref_analog: EC:1.1.1.30
xref_analog: IMR:0200030
xref_analog: IMR:0200064
xref_analog: IMR:0200218
xref_analog: IMR:0200248
xref_analog: IMR:0200521
xref_analog: KEGG:map00072
xref_analog: KEGG:map00650
xref_analog: KEGG:R01361
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001427 ! Butanoate metabolism

[Term]
id: IEV:0002822
name: Adenosine + H2O => Inosine + NH3( EC:3.5.4.4 )
xref_analog: EC:3.5.4.4
xref_analog: IMR:0100126
xref_analog: IMR:0200075
xref_analog: IMR:0200194
xref_analog: IMR:0200357
xref_analog: KEGG:map00230
xref_analog: KEGG:R01560
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002823
name: Acetyl-CoA + Glycine = CoA + L-2-Amino-3-oxo-butanoic acid( EC:2.3.1.29 )
xref_analog: EC:2.3.1.29
xref_analog: IMR:0100118
xref_analog: IMR:0200354
xref_analog: IMR:0200414
xref_analog: KEGG:C03508
xref_analog: KEGG:map00260
xref_analog: KEGG:R00371
is_a: IEV:0002399 ! Transacetylation
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism

[Term]
id: IEV:0002824
name: L-Alanine + 2-Oxo-glutaric acid = Pyruvic acid + L-Glutamic acid( EC:2.6.1.2 )
xref_analog: EC:2.6.1.2
xref_analog: IMR:0100119
xref_analog: IMR:0200251
xref_analog: IMR:0200331
xref_analog: IMR:0200480
xref_analog: KEGG:map00250
xref_analog: KEGG:map00710
xref_analog: KEGG:R00258
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001410 ! Alanine and aspartate metabolism
relationship: part_of IEV:0001411 ! Glutamate metabolism

[Term]
id: IEV:0002825
name: ADP + Phosphoenol-pyruvic acid => ATP + Pyruvic acid( EC:2.7.1.40 )
xref_analog: EC:2.7.1.40
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200223
xref_analog: IMR:0200331
xref_analog: KEGG:map00010
xref_analog: KEGG:map00230
xref_analog: KEGG:map00620
xref_analog: KEGG:map00710
xref_analog: KEGG:R00200
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001413 ! Glycolysis and Gluconeogenesis
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002826
name: Prostaglandin H2 => Prostaglandin E2( EC:5.3.99.3 )
xref_analog: EC:5.3.99.3
xref_analog: IMR:0200146
xref_analog: IMR:0200253
xref_analog: KEGG:map00590
xref_analog: KEGG:R02265
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001449 ! Arachidonic acid metabolism

[Term]
id: IEV:0002827
name: NAD+ + (S)-3-Hydroxy-butanoyl-CoA = NADH + Acetoacetyl-CoA + H+( EC:1.1.1.35 )
comment: NAD+ + (S)-3-Hydroxy-butanoyl-CoA = NADH + Acetoacetyl-CoA( EC:1.1.1.35 )
xref_analog: EC:1.1.1.35
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200395
xref_analog: IMR:0200410
xref_analog: IMR:0200521
xref_analog: KEGG:map00071
xref_analog: KEGG:map00310
xref_analog: KEGG:map00380
xref_analog: KEGG:map00650
xref_analog: KEGG:R01975
is_a: IEV:0002725 ! (3S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+( EC:1.1.1.35 )
relationship: part_of IEV:0001427 ! Butanoate metabolism
relationship: part_of IEV:0001457 ! Lysine degradation
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0002828
name: 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + Pyrophosphate = 5-Amino-4-imidazole-carboxyamide + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.7 )
comment: 5'-Phospho-ribosyl-4-carboxamido-5-amino-imidazole + Pyrophosphate = 5-Amino-4-imidazole-carboxyamide + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.7 )
xref_analog: EC:2.4.2.7
xref_analog: IMR:0200179
xref_analog: IMR:0200280
xref_analog: IMR:0200284
xref_analog: IMR:0200291
xref_analog: KEGG:map00230
xref_analog: KEGG:R04378
is_a: IEV:0002560 ! Glycosylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002829
name: ATP + D-Fructose => ADP + beta-D-Fructose 6-phosphate( EC:2.7.1.1 )
comment: ATP + D-Fructose => ADP + D-Fructose 6-phosphate( EC:2.7.1.1 )
xref_analog: EC:2.7.1.1
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200474
xref_analog: KEGG:C05345
xref_analog: KEGG:map00051
xref_analog: KEGG:R00867
is_a: IEV:0002744 ! ATP + D-hexose = ADP + D-hexose 6-phosphate( EC:2.7.1.1 )
relationship: part_of IEV:0001417 ! Fructose and mannose metabolism

[Term]
id: IEV:0002830
name: 5,6-Dihydro-uracil + H2O = 3-Ureidopropionate( EC:3.5.2.2 )
comment: 5,6-Dihydro-uracil + H2O = Ureido-propanoic acid( EC:3.5.2.2 )
xref_analog: EC:3.5.2.2
xref_analog: IMR:0200276
xref_analog: IMR:0200357
xref_analog: IMR:0200363
xref_analog: KEGG:map00240
xref_analog: KEGG:map00410
xref_analog: KEGG:map00770
xref_analog: KEGG:R02269
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002831
name: ATP + NAD+ => ADP + NADP+( EC:2.7.1.23 )
xref_analog: EC:2.7.1.23
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200067
xref_analog: IMR:0200248
xref_analog: KEGG:map00760
xref_analog: KEGG:R00104
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001510 ! Nicotinate and nicotinamide metabolism

[Term]
id: IEV:0002832
name: Coproporphyrinogen III + O2 => Protoporphyrinogen IX + 2 CO2 + 2 H2O( EC:1.3.3.3 )
comment: Coproporphyrinogen III => Protoporphyrinogen IX + 2 CO2( EC:1.3.3.3 ):multi-step reaction
xref_analog: EC:1.3.3.3
xref_analog: IMR:0200217
xref_analog: IMR:0200258
xref_analog: IMR:0200324
xref_analog: IMR:0200357
xref_analog: IMR:0200523
xref_analog: KEGG:map00860
xref_analog: KEGG:R03220
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001516 ! Porphyrin and chlorophyll metabolism

[Term]
id: IEV:0002833
name: 3-Methyl-butanoyl-CoA + FAD = 3-Methylbut-2-enoyl-CoA + FADH2( EC:1.3.99.3 )
comment: 3-Methyl-butanoyl-CoA + Acceptor = 3-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.3 )
xref_analog: EC:1.3.99.3
xref_analog: IMR:0200158
xref_analog: IMR:0200298
xref_analog: KEGG:C00016
xref_analog: KEGG:C01352
xref_analog: KEGG:map00280
xref_analog: KEGG:R04095
is_a: IEV:0002732 ! Acyl-CoA + Acceptor = 2,3-dehydroacyl-CoA + Reduced acceptor( EC:1.3.99.3 )
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0002834
name: 2-Oxo-glutaric acid + L-erythro-4-Hydroxy-glutamic acid = L-Glutamic acid + D-4-Hydroxy-2-oxo-glutaric acid( EC:2.6.1.1 )
xref_analog: EC:2.6.1.1
xref_analog: IMR:0100119
xref_analog: IMR:0200091
xref_analog: IMR:0200480
xref_analog: KEGG:C05946
xref_analog: KEGG:map00330
xref_analog: KEGG:R05052
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0002835
name: D-Glycerate 2-phosphate = Phosphoenol-pyruvic acid + H2O( EC:4.2.1.11 )
xref_analog: EC:4.2.1.11
xref_analog: IMR:0200223
xref_analog: IMR:0200357
xref_analog: IMR:0200405
xref_analog: KEGG:map00010
xref_analog: KEGG:R00658
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001413 ! Glycolysis and Gluconeogenesis

[Term]
id: IEV:0002836
name: S-Adenosyl-L-homocysteine + H2O => Adenosine + L-Homocysteine( EC:3.3.1.1 )
xref_analog: EC:3.3.1.1
xref_analog: IMR:0100126
xref_analog: IMR:0200039
xref_analog: IMR:0200151
xref_analog: IMR:0200357
xref_analog: KEGG:map00270
xref_analog: KEGG:R00192
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001466 ! Methionine and Cysteine metabolism

[Term]
id: IEV:0002837
name: NADP+ + Cholesterol = NADPH + 7-Dehydro-cholesterol + H+( EC:1.3.1.21 )
comment: NADP+ + Cholesterol = NADPH + 7-Dehydro-cholesterol( EC:1.3.1.21 )
xref_analog: EC:1.3.1.21
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200463
xref_analog: IMR:0200486
xref_analog: IMR:0200510
xref_analog: KEGG:map00100
xref_analog: KEGG:R01456
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001443 ! Steroid biosynthesis

[Term]
id: IEV:0002838
name: NAD+ + Enzyme N6-(dihydrolipoyl)lysine = NADH + Enzyme N6-(lipoyl)lysine + H+( EC:1.8.1.4 )
comment: NAD+ + Dihydro-lipoamide = NADH + Lipoamide( EC:1.8.1.4 )
xref_analog: EC:1.8.1.4
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200521
xref_analog: KEGG:C15972
xref_analog: KEGG:C15973
xref_analog: KEGG:map00010
xref_analog: KEGG:map00020
xref_analog: KEGG:map00280
xref_analog: KEGG:map00620
xref_analog: KEGG:R07618
is_a: IEV:0002736 ! protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+( EC:1.8.1.4 )
relationship: part_of IEV:0001415 ! Citrate cycle (TCA cycle)
relationship: part_of IEV:0001424 ! Pyruvate metabolism

[Term]
id: IEV:0002839
name: Allantoic acid + H2O => (-)-Ureidoglycolate + Urea( EC:3.5.3.4 )
comment: Allantoic acid + H2O => Ureido-glycolic acid + Urea( EC:3.5.3.4 )
xref_analog: EC:3.5.3.4
xref_analog: IMR:0200093
xref_analog: IMR:0200111
xref_analog: IMR:0200357
xref_analog: IMR:0200437
xref_analog: KEGG:map00230
xref_analog: KEGG:R02422
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002840
name: UDP-D-glucose + alpha-D-Galactose 1-phosphate = D-Glucose 1-phosphate + UDP-D-galactose( EC:2.7.7.12 )
comment: UDP-D-glucose + D-Galactose 1-phosphate = D-Glucose 1-phosphate + UDP-D-galactose( EC:2.7.7.12 )
xref_analog: EC:2.7.7.12
xref_analog: IMR:0200190
xref_analog: IMR:0200227
xref_analog: IMR:0200283
xref_analog: IMR:0200304
xref_analog: KEGG:map00052
xref_analog: KEGG:map00520
xref_analog: KEGG:R00955
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001418 ! Galactose metabolism

[Term]
id: IEV:0002841
name: 1D-myo-Inositol 4-phosphate + H2O => myo-Inositol + Orthophosphate( EC:3.1.3.25 )
xref_analog: EC:3.1.3.25
xref_analog: IMR:0200102
xref_analog: IMR:0200177
xref_analog: IMR:0200357
xref_analog: IMR:0200419
xref_analog: KEGG:map00562
xref_analog: KEGG:map04070
xref_analog: KEGG:R01186
is_a: IEV:0002750 ! myo-inositol phosphate + H2O = myo-inositol + Orthophosphate( EC:3.1.3.25 )
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0002842
name: 2-Oxo-glutaric acid + L-Cysteine = DL-Glutamic acid + 3-Mercapto-pyruvic acid( EC:2.6.1.1 )
comment: 2-Oxo-glutaric acid + L-Cysteine = L-Glutamic acid + 3-Mercapto-pyruvic acid( EC:2.6.1.1 )
xref_analog: EC:2.6.1.1
xref_analog: IMR:0200007
xref_analog: IMR:0200467
xref_analog: IMR:0200480
xref_analog: KEGG:C00302
xref_analog: KEGG:map00270
xref_analog: KEGG:R00896
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001466 ! Methionine and Cysteine metabolism

[Term]
id: IEV:0002843
name: NAD+ + (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA = NADH + 2-Methyl-3-acetoacetyl-CoA + H+( EC:1.1.1.35 )
comment: NAD+ + (S)-3-Hydroxy-2-methyl-butanoyl-CoA = NADH + 2-Methyl-3-acetoacetyl-CoA( EC:1.1.1.35 )
xref_analog: EC:1.1.1.35
xref_analog: IMR:0200030
xref_analog: IMR:0200207
xref_analog: IMR:0200248
xref_analog: IMR:0200288
xref_analog: IMR:0200521
xref_analog: KEGG:map00280
xref_analog: KEGG:R04203
is_a: IEV:0002725 ! (3S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+( EC:1.1.1.35 )
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0002844
name: Glutaryl-CoA + Acceptor => Crotonoyl-CoA + CO2 + Reduced acceptor( EC:1.3.99.7 )
xref_analog: EC:1.3.99.7
xref_analog: IMR:0200121
xref_analog: IMR:0200224
xref_analog: IMR:0200256
xref_analog: IMR:0200300
xref_analog: IMR:0200324
xref_analog: KEGG:map00310
xref_analog: KEGG:map00380
xref_analog: KEGG:R02488
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001457 ! Lysine degradation
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0002845
name: ATP + dTMP = ADP + dTDP( EC:2.7.4.9 )
xref_analog: EC:2.7.4.9
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200187
xref_analog: IMR:0200338
xref_analog: KEGG:map00240
xref_analog: KEGG:R02094
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002846
name: D-Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate = D-Ribose 5-phosphate + D-Xylulose 5-phosphate( EC:2.2.1.1 )
xref_analog: EC:2.2.1.1
xref_analog: IMR:0200058
xref_analog: IMR:0200060
xref_analog: IMR:0200141
xref_analog: IMR:0200169
xref_analog: KEGG:map00030
xref_analog: KEGG:map00710
xref_analog: KEGG:R01641
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001414 ! Pentose phosphate pathway

[Term]
id: IEV:0002847
name: 2-Oxo-glutaric acid + L-Cysteic acid = L-Glutamic acid + 3-Sulfo-pyruvic acid( EC:2.6.1.1 )
xref_analog: EC:2.6.1.1
xref_analog: IMR:0100119
xref_analog: IMR:0200397
xref_analog: IMR:0200417
xref_analog: IMR:0200480
xref_analog: KEGG:map00270
xref_analog: KEGG:R02433
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001466 ! Methionine and Cysteine metabolism

[Term]
id: IEV:0002848
name: NAD+ + Methylimidazole acetaldehyde + H2O = NADH + Methylimidazoleacetic acid + H+( EC:1.2.1.5 )
comment: NAD+ + 3-Methyl-imidazole acetaldehyde + H2O = NADH + 3-Methyl-imidazole-acetic acid( EC:1.2.1.5 )
xref_analog: EC:1.2.1.5
xref_analog: IMR:0200030
xref_analog: IMR:0200114
xref_analog: IMR:0200248
xref_analog: IMR:0200325
xref_analog: IMR:0200357
xref_analog: IMR:0200521
xref_analog: KEGG:map00340
xref_analog: KEGG:R04996
is_a: IEV:0002730 ! Aldehyde + NADP+ + H2O = Carboxylate + NADPH + H+( EC:1.2.1.5 )
relationship: part_of IEV:0001459 ! Histidine metabolism

[Term]
id: IEV:0002849
name: 5,6-Dihydro-thymine + H2O = 3-Ureidoisobutyrate( EC:3.5.2.2 )
comment: 5,6-Dihydro-thymine + H2O = 3-Ureido-2-methyl-propanoic acid( EC:3.5.2.2 )
xref_analog: EC:3.5.2.2
xref_analog: IMR:0200132
xref_analog: IMR:0200343
xref_analog: IMR:0200357
xref_analog: KEGG:map00240
xref_analog: KEGG:R03055
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002850
name: NAD+ + (S)-3-Hydroxyisobutyrate = NADH + (S)-Methyl-malonate semialdehyde + H+( EC:1.1.1.35 )
comment: NAD+ + (S)-3-Hydroxy-2-methyl-propanoic acid = NADH + (S)-Methyl-malonate semialdehyde( EC:1.1.1.35 )
xref_analog: EC:1.1.1.35
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200297
xref_analog: IMR:0200385
xref_analog: IMR:0200521
xref_analog: KEGG:map00280
xref_analog: KEGG:R05066
is_a: IEV:0002725 ! (3S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+( EC:1.1.1.35 )
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0002851
name: NADP+ + beta-D-Glucose = NADPH + D-Glucono-1,5-lactone + H+( EC:1.1.1.47 )
comment: NADP+ + D-Glucose = NADPH + D-Glucono-1,5-lactone( EC:1.1.1.47 )
xref_analog: EC:1.1.1.47
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200242
xref_analog: IMR:0200463
xref_analog: KEGG:C00221
xref_analog: KEGG:map00030
xref_analog: KEGG:R01521
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001414 ! Pentose phosphate pathway

[Term]
id: IEV:0002852
name: NADP+ + 5,6-Dihydro-thymine = NADPH + Thymine + H+( EC:1.3.1.2 )
comment: NADP+ + 5,6-Dihydro-thymine = NADPH + Thymine( EC:1.3.1.2 )
xref_analog: EC:1.3.1.2
xref_analog: IMR:0200030
xref_analog: IMR:0200036
xref_analog: IMR:0200067
xref_analog: IMR:0200343
xref_analog: IMR:0200463
xref_analog: KEGG:map00240
xref_analog: KEGG:R01415
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002853
name: D-Glycerate 2-phosphate = D-Glycerate 3-phosphate( EC:5.4.2.1 )
xref_analog: EC:5.4.2.1
xref_analog: IMR:0200320
xref_analog: IMR:0200405
xref_analog: KEGG:map00010
xref_analog: KEGG:R01518
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001413 ! Glycolysis and Gluconeogenesis

[Term]
id: IEV:0002854
name: GTP + Oxaloacetic acid = GDP + Phosphoenol-pyruvic acid + CO2( EC:4.1.1.32 )
xref_analog: EC:4.1.1.32
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: IMR:0200223
xref_analog: IMR:0200324
xref_analog: IMR:0200339
xref_analog: KEGG:map00010
xref_analog: KEGG:map00020
xref_analog: KEGG:map00620
xref_analog: KEGG:R00431
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001415 ! Citrate cycle (TCA cycle)

[Term]
id: IEV:0002855
name: D-Ribose 5-phosphate = D-Ribulose 5-phosphate( EC:5.3.1.6 )
xref_analog: EC:5.3.1.6
xref_analog: IMR:0200060
xref_analog: IMR:0200061
xref_analog: KEGG:map00030
xref_analog: KEGG:map00710
xref_analog: KEGG:R01056
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001414 ! Pentose phosphate pathway

[Term]
id: IEV:0002856
name: (R)-Methyl-malonyl-CoA = (S)-Methyl-malonyl-CoA( EC:5.1.99.1 )
xref_analog: EC:5.1.99.1
xref_analog: IMR:0200016
xref_analog: IMR:0200515
xref_analog: KEGG:map00280
xref_analog: KEGG:map00640
xref_analog: KEGG:R02765
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001426 ! Propanoate metabolism

[Term]
id: IEV:0002857
name: Prostaglandin H2 => Thromboxane A2( EC:5.3.99.5 )
xref_analog: EC:5.3.99.5
xref_analog: IMR:0200253
xref_analog: IMR:0200489
xref_analog: KEGG:map00590
xref_analog: KEGG:R02268
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001449 ! Arachidonic acid metabolism

[Term]
id: IEV:0002858
name: NAD+ + 4-Trimethyl-ammonio-butanal + H2O = NADH + 4-Trimethyl-ammonio-butanoic acid + H+( EC:1.2.1.3 )
comment: NAD+ + 4-Trimethyl-ammonio-butanal + H2O = NADH + 4-Trimethyl-ammonio-butanoic acid( EC:1.2.1.3 )
xref_analog: EC:1.2.1.3
xref_analog: IMR:0200030
xref_analog: IMR:0200070
xref_analog: IMR:0200168
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: IMR:0200521
xref_analog: KEGG:map00310
xref_analog: KEGG:R03283
is_a: IEV:0002729 ! Aldehyde + NAD+ + H2O = Carboxylate + NADH + H+( EC:1.2.1.3 )
relationship: part_of IEV:0001457 ! Lysine degradation

[Term]
id: IEV:0002859
name: 4-Maleyl-acetoacetic acid => 4-Fumaryl-acetoacetic acid( EC:5.2.1.2 )
xref_analog: EC:5.2.1.2
xref_analog: IMR:0200245
xref_analog: IMR:0200507
xref_analog: KEGG:map00350
xref_analog: KEGG:map00643
xref_analog: KEGG:R03181
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0002860
name: N-Ribosyl-nicotinamide + Orthophosphate = Nicotinamide + D-Ribose 1-phosphate( EC:2.4.2.1 )
xref_analog: EC:2.4.2.1
xref_analog: IMR:0200025
xref_analog: IMR:0200102
xref_analog: IMR:0200479
xref_analog: KEGG:C00620
xref_analog: KEGG:map00760
xref_analog: KEGG:R02294
is_a: IEV:0002742 ! purine nucleoside + Orthophosphate = purine + D-ribose 1-phosphate( EC:2.4.2.1 )
relationship: part_of IEV:0001510 ! Nicotinate and nicotinamide metabolism

[Term]
id: IEV:0002861
name: ATP + L-Glutamic acid + NH3 = ADP + L-Glutamine + Orthophosphate( EC:6.3.1.2 )
xref_analog: EC:6.3.1.2
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0100119
xref_analog: IMR:0200075
xref_analog: IMR:0200102
xref_analog: IMR:0200448
xref_analog: KEGG:map00250
xref_analog: KEGG:map00330
xref_analog: KEGG:map00910
xref_analog: KEGG:R00253
is_a: IEV:0002675 ! Amidation
relationship: part_of IEV:0001411 ! Glutamate metabolism

[Term]
id: IEV:0002862
name: 5-Methyl-tetrahydro-folic acid + L-Homocysteine => Tetrahydrofolate + L-Methionine( EC:2.1.1.13 )
comment: 5-Methyl-tetrahydro-folic acid + L-Homocysteine => L-Tetrahydro-folic acid + L-Methionine( EC:2.1.1.13 )
xref_analog: EC:2.1.1.13
xref_analog: IMR:0200039
xref_analog: IMR:0200330
xref_analog: IMR:0200408
xref_analog: IMR:0200488
xref_analog: KEGG:map00270
xref_analog: KEGG:map00670
xref_analog: KEGG:R00946
is_a: IEV:0000433 ! Transmethylation
relationship: part_of IEV:0001466 ! Methionine and Cysteine metabolism
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0002863
name: ATP + L-Methionine + tRNA(Met) => AMP + L-Methionyl-tRNA(Met) + Pyrophosphate( EC:6.1.1.10 )
xref_analog: EC:6.1.1.10
xref_analog: IMR:0001351
xref_analog: IMR:0200034
xref_analog: IMR:0200083
xref_analog: IMR:0200280
xref_analog: IMR:0200355
xref_analog: IMR:0200488
xref_analog: KEGG:map00970
xref_analog: KEGG:R03659
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001466 ! Methionine and Cysteine metabolism

[Term]
id: IEV:0002864
name: AMP + Pyrophosphate = Adenine + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.7 )
comment: AMP + Pyrophosphate = Adenine + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.7 )
xref_analog: EC:2.4.2.7
xref_analog: IMR:0200083
xref_analog: IMR:0200179
xref_analog: IMR:0200280
xref_analog: IMR:0200350
xref_analog: KEGG:map00230
xref_analog: KEGG:R00190
is_a: IEV:0002560 ! Glycosylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002865
name: L-Serine => Pyruvic acid + NH3( EC:4.3.1.17 )
xref_analog: EC:4.3.1.17
xref_analog: IMR:0200075
xref_analog: IMR:0200331
xref_analog: IMR:0200453
xref_analog: KEGG:map00260
xref_analog: KEGG:R00220
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism

[Term]
id: IEV:0002866
name: NADPH + 6,7-Dihydro-biopterin + H+ => NADP+ + Tetrahydrobiopterin( EC:1.5.1.34 )
comment: NADPH + 6,7-Dihydro-biopterin => NADP+ + 5,6,7,8-Tetrahydro-biopterin( EC:1.5.1.34 )
xref_analog: EC:1.5.1.34
xref_analog: IMR:0200030
xref_analog: IMR:0200045
xref_analog: IMR:0200067
xref_analog: IMR:0200209
xref_analog: IMR:0200463
xref_analog: KEGG:map00790
xref_analog: KEGG:R01794
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0002867
name: ATP + dGMP = ADP + dGDP( EC:2.7.4.8 )
xref_analog: EC:2.7.4.8
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200365
xref_analog: IMR:0200505
xref_analog: KEGG:map00230
xref_analog: KEGG:R02090
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002868
name: Melatonin + O2 + Reduced flavoprotein => 6-Hydroxy-melatonin + H2O + Oxidized flavoprotein( EC:1.14.14.1 )
xref_analog: EC:1.14.14.1
xref_analog: IMR:0100069
xref_analog: IMR:0200041
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200450
xref_analog: IMR:0200519
xref_analog: KEGG:map00380
xref_analog: KEGG:R03629
is_a: IEV:0002727 ! Alkane + Reduced flavoprotein + O2 = ROH + Oxidized flavoprotein + H2O( EC:1.14.14.1 )
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0002869
name: IMP + Pyrophosphate = Hypoxanthine + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.8 )
comment: IMP + Pyrophosphate = Hypoxanthine + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.8 )
xref_analog: EC:2.4.2.8
xref_analog: IMR:0200173
xref_analog: IMR:0200179
xref_analog: IMR:0200221
xref_analog: IMR:0200280
xref_analog: KEGG:map00230
xref_analog: KEGG:R01132
is_a: IEV:0002560 ! Glycosylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002870
name: 2,5-Dihydroxy-phenyl-acetic acid + O2 => 4-Maleyl-acetoacetic acid( EC:1.13.11.5 )
xref_analog: EC:1.13.11.5
xref_analog: IMR:0200217
xref_analog: IMR:0200245
xref_analog: IMR:0200254
xref_analog: KEGG:map00350
xref_analog: KEGG:map00643
xref_analog: KEGG:R02519
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0002871
name: NADPH + Folic acid + H+ => NADP+ + 7,8-Dihydro-folic acid( EC:1.5.1.3 )
comment: NADPH + Folic acid => NADP+ + 7,8-Dihydro-folic acid( EC:1.5.1.3 )
xref_analog: EC:1.5.1.3
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200185
xref_analog: IMR:0200356
xref_analog: IMR:0200463
xref_analog: KEGG:map00670
xref_analog: KEGG:map00790
xref_analog: KEGG:R02236
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0002872
name: 3-Hydroxy-propanoyl-CoA = Propenoyl-CoA + H2O( EC:4.2.1.17 )
xref_analog: EC:4.2.1.17
xref_analog: IMR:0200200
xref_analog: IMR:0200357
xref_analog: IMR:0200441
xref_analog: KEGG:map00410
xref_analog: KEGG:map00640
xref_analog: KEGG:R03045
is_a: IEV:0002759 ! (3S)-3-hydroxyacyl-CoA = trans-2,3-Dehydroacyl-CoA + H2O( EC:4.2.1.17 )
relationship: part_of IEV:0001426 ! Propanoate metabolism

[Term]
id: IEV:0002873
name: Farnesyl diphosphate + Isopentenyl diphosphate = Geranyl-geranyl diphosphate + Pyrophosphate( EC:2.5.1.29 )
xref_analog: EC:2.5.1.29
xref_analog: IMR:0200097
xref_analog: IMR:0200280
xref_analog: IMR:0200287
xref_analog: IMR:0200316
xref_analog: KEGG:map00900
xref_analog: KEGG:R02061
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001443 ! Steroid biosynthesis

[Term]
id: IEV:0002874
name: NAD+ + (S)-Lactic acid = NADH + Pyruvic acid + H+( EC:1.1.1.27 )
comment: NAD+ + (S)-Lactic acid = NADH + Pyruvic acid( EC:1.1.1.27 )
xref_analog: EC:1.1.1.27
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200270
xref_analog: IMR:0200331
xref_analog: IMR:0200521
xref_analog: KEGG:map00010
xref_analog: KEGG:map00620
xref_analog: KEGG:R00703
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001424 ! Pyruvate metabolism

[Term]
id: IEV:0002875
name: Dimethylallyl diphosphate = Isopentenyl diphosphate( EC:5.3.3.2 )
xref_analog: EC:5.3.3.2
xref_analog: IMR:0200094
xref_analog: IMR:0200287
xref_analog: KEGG:map00900
xref_analog: KEGG:R01123
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001443 ! Steroid biosynthesis

[Term]
id: IEV:0002876
name: Guanine + H2O => Xanthine + NH3( EC:3.5.4.3 )
xref_analog: EC:3.5.4.3
xref_analog: IMR:0200075
xref_analog: IMR:0200319
xref_analog: IMR:0200357
xref_analog: IMR:0200439
xref_analog: KEGG:map00230
xref_analog: KEGG:R01676
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002877
name: ITP + H2O => IDP + Orthophosphate( EC:3.6.1.5 )
xref_analog: EC:3.6.1.5
xref_analog: IMR:0200074
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: IMR:0200511
xref_analog: KEGG:map00230
xref_analog: KEGG:R00719
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002878
name: L-Glutamine + D-Fructose 6-phosphate = L-Glutamic acid + D-Glucosamine 6-phosphate( EC:2.6.1.16 )
xref_analog: EC:2.6.1.16
xref_analog: IMR:0100119
xref_analog: IMR:0200228
xref_analog: IMR:0200261
xref_analog: IMR:0200448
xref_analog: KEGG:map00250
xref_analog: KEGG:map00520
xref_analog: KEGG:R00768
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001421 ! Aminosugars metabolism

[Term]
id: IEV:0002879
name: ATP + UMP = ADP + UDP( EC:2.7.4.14 )
xref_analog: EC:2.7.4.14
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200206
xref_analog: IMR:0200409
xref_analog: KEGG:map00240
xref_analog: KEGG:R00158
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002880
name: XMP + Pyrophosphate = Xanthine + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.8 )
comment: XMP + Pyrophosphate = Xanthine + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.8 )
xref_analog: EC:2.4.2.8
xref_analog: IMR:0200165
xref_analog: IMR:0200179
xref_analog: IMR:0200280
xref_analog: IMR:0200439
xref_analog: KEGG:map00230
xref_analog: KEGG:R02142
is_a: IEV:0002560 ! Glycosylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002881
name: D-Fructose 2,6-bisphosphate + H2O => beta-D-Fructose 6-phosphate + Orthophosphate( EC:3.1.3.46 )
comment: D-Fructose 2,6-bisphosphate + H2O => D-Fructose 6-phosphate + Orthophosphate( EC:3.1.3.46 )
xref_analog: EC:3.1.3.46
xref_analog: IMR:0200102
xref_analog: IMR:0200263
xref_analog: IMR:0200357
xref_analog: KEGG:C05345
xref_analog: KEGG:map00051
xref_analog: KEGG:R02731
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001417 ! Fructose and mannose metabolism

[Term]
id: IEV:0002882
name: (S)-Dihydro-orotic acid + O2 = Orotic acid + H2O2( EC:1.3.3.1 )
xref_analog: EC:1.3.3.1
xref_analog: IMR:0200217
xref_analog: IMR:0200265
xref_analog: IMR:0200393
xref_analog: IMR:0200487
xref_analog: KEGG:map00240
xref_analog: KEGG:R01867
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002883
name: ATP + 2-Deoxy-D-ribose => ADP + 2-Deoxy-D-ribose 5-phosphate( EC:2.7.1.15 )
xref_analog: EC:2.7.1.15
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200147
xref_analog: IMR:0200449
xref_analog: KEGG:map00030
xref_analog: KEGG:R02750
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001414 ! Pentose phosphate pathway

[Term]
id: IEV:0002884
name: 2-Methyl-propanoyl-CoA + Acceptor = 2-Methylprop-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.3 )
xref_analog: EC:1.3.99.3
xref_analog: IMR:0200164
xref_analog: IMR:0200174
xref_analog: IMR:0200224
xref_analog: IMR:0200300
xref_analog: KEGG:map00280
xref_analog: KEGG:R02661
is_a: IEV:0002732 ! Acyl-CoA + Acceptor = 2,3-dehydroacyl-CoA + Reduced acceptor( EC:1.3.99.3 )
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0002885
name: dUMP + 5,10-Methylene-tetrahydro-folic acid => dTMP + 7,8-Dihydro-folic acid( EC:2.1.1.45 )
xref_analog: EC:2.1.1.45
xref_analog: IMR:0200008
xref_analog: IMR:0200185
xref_analog: IMR:0200187
xref_analog: IMR:0200517
xref_analog: KEGG:map00240
xref_analog: KEGG:map00670
xref_analog: KEGG:R02101
is_a: IEV:0000433 ! Transmethylation
relationship: part_of IEV:0001451 ! Pyrimidine metabolism
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0002886
name: Nicotinamide D-ribonucleotide + H2O => N-Ribosyl-nicotinamide + Orthophosphate( EC:3.1.3.5 )
xref_analog: EC:3.1.3.5
xref_analog: IMR:0200102
xref_analog: IMR:0200166
xref_analog: IMR:0200357
xref_analog: IMR:0200479
xref_analog: KEGG:map00760
xref_analog: KEGG:R02323
is_a: IEV:0002751 ! 5'-ribonucleotide + H2O = ribonucleoside + phosphate( EC:3.1.3.5 )
relationship: part_of IEV:0001510 ! Nicotinate and nicotinamide metabolism

[Term]
id: IEV:0002887
name: L-Tryptophan + Tetrahydrobiopterin + O2 => 5-Hydroxy-L-tryptophan + 6,7-Dihydro-biopterin + H2O( EC:1.14.16.4 )
xref_analog: EC:1.14.16.4
xref_analog: IMR:0200045
xref_analog: IMR:0200112
xref_analog: IMR:0200209
xref_analog: IMR:0200217
xref_analog: IMR:0200307
xref_analog: IMR:0200357
xref_analog: KEGG:map00380
xref_analog: KEGG:R01814
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0002888
name: GMP + Pyrophosphate = Guanine + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.7 )
comment: GMP + Pyrophosphate = Guanine + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.7 )
xref_analog: EC:2.4.2.7
xref_analog: IMR:0200179
xref_analog: IMR:0200280
xref_analog: IMR:0200292
xref_analog: IMR:0200319
xref_analog: KEGG:map00230
xref_analog: KEGG:R01229
is_a: IEV:0002560 ! Glycosylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002889
name: ATP + dAMP = ADP + dADP( EC:2.7.4.3 )
xref_analog: EC:2.7.4.3
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200160
xref_analog: IMR:0200237
xref_analog: KEGG:map00230
xref_analog: KEGG:R01547
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002890
name: 5,10-Methenyl-tetrahydro-folic acid + H2O = 10-Formyl-tetrahydro-folic acid + H+( EC:3.5.4.9 )
comment: 5,10-Methenyl-tetrahydro-folic acid + H2O = 10-Formyl-tetrahydro-folic acid( EC:3.5.4.9 )
xref_analog: EC:3.5.4.9
xref_analog: IMR:0200030
xref_analog: IMR:0200159
xref_analog: IMR:0200347
xref_analog: IMR:0200357
xref_analog: KEGG:map00630
xref_analog: KEGG:map00670
xref_analog: KEGG:R01655
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0002892
name: (S)-3-Hydroxy-butanoyl-CoA = Crotonoyl-CoA + H2O( EC:4.2.1.17 )
xref_analog: EC:4.2.1.17
xref_analog: IMR:0200121
xref_analog: IMR:0200357
xref_analog: IMR:0200395
xref_analog: KEGG:map00071
xref_analog: KEGG:map00310
xref_analog: KEGG:map00380
xref_analog: KEGG:map00632
xref_analog: KEGG:map00650
xref_analog: KEGG:R03026
is_a: IEV:0002759 ! (3S)-3-hydroxyacyl-CoA = trans-2,3-Dehydroacyl-CoA + H2O( EC:4.2.1.17 )
relationship: part_of IEV:0001427 ! Butanoate metabolism
relationship: part_of IEV:0001457 ! Lysine degradation
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0002893
name: Acetyl-CoA + Oxaloacetic acid + H2O => CoA + Citric acid( EC:2.3.3.1 )
xref_analog: EC:2.3.3.1
xref_analog: IMR:0200339
xref_analog: IMR:0200354
xref_analog: IMR:0200357
xref_analog: IMR:0200414
xref_analog: IMR:0200473
xref_analog: KEGG:map00020
xref_analog: KEGG:map00630
xref_analog: KEGG:R00351
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001415 ! Citrate cycle (TCA cycle)

[Term]
id: IEV:0002894
name: L-Cystathionine + H2O => L-Cysteine + 2-Oxo-butanoic acid + NH3( EC:4.4.1.1 )
xref_analog: EC:4.4.1.1
xref_analog: IMR:0200075
xref_analog: IMR:0200127
xref_analog: IMR:0200220
xref_analog: IMR:0200357
xref_analog: IMR:0200467
xref_analog: KEGG:map00260
xref_analog: KEGG:map00270
xref_analog: KEGG:map00910
xref_analog: KEGG:R01001
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism
relationship: part_of IEV:0001466 ! Methionine and Cysteine metabolism

[Term]
id: IEV:0002895
name: ADP-ribose + H2O => AMP + D-Ribose 5-phosphate( EC:3.6.1.13 )
comment: ADP-5-ribose + H2O => AMP + D-Ribose 5-phosphate( EC:3.6.1.13 )
xref_analog: EC:3.6.1.13
xref_analog: IMR:0200060
xref_analog: IMR:0200083
xref_analog: IMR:0200134
xref_analog: IMR:0200357
xref_analog: KEGG:map00230
xref_analog: KEGG:R01054
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002896
name: ATP + Glycine + tRNA(Gly) => AMP + Glycyl-tRNA(Gly) + Pyrophosphate( EC:6.1.1.14 )
xref_analog: EC:6.1.1.14
xref_analog: IMR:0001351
xref_analog: IMR:0100118
xref_analog: IMR:0200083
xref_analog: IMR:0200215
xref_analog: IMR:0200280
xref_analog: IMR:0200433
xref_analog: KEGG:map00970
xref_analog: KEGG:R03654
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism

[Term]
id: IEV:0002897
name: Deoxy-adenosine + H2O => Deoxy-inosine + NH3( EC:3.5.4.4 )
xref_analog: EC:3.5.4.4
xref_analog: IMR:0200075
xref_analog: IMR:0200197
xref_analog: IMR:0200226
xref_analog: IMR:0200357
xref_analog: KEGG:map00230
xref_analog: KEGG:R02556
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002898
name: ATP + XMP + L-Glutamine + H2O => AMP + GMP + L-Glutamic acid + Pyrophosphate( EC:6.3.5.2 )
xref_analog: EC:6.3.5.2
xref_analog: IMR:0001351
xref_analog: IMR:0100119
xref_analog: IMR:0200083
xref_analog: IMR:0200165
xref_analog: IMR:0200280
xref_analog: IMR:0200292
xref_analog: IMR:0200357
xref_analog: IMR:0200448
xref_analog: KEGG:map00230
xref_analog: KEGG:R01231
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002899
name: Tyramine + H2O + O2 => 4-Hydroxy-phenyl-acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
xref_analog: EC:1.4.3.4
xref_analog: IMR:0100124
xref_analog: IMR:0200040
xref_analog: IMR:0200075
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200487
xref_analog: KEGG:map00350
xref_analog: KEGG:R02382
is_a: IEV:0002734 ! Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.4 )
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0002900
name: 2 NADPH + 6-Pyruvoyltetrahydropterin + 2 H+ => 2 NADP+ + Tetrahydrobiopterin( EC:1.1.1.153 )
comment: 2 NADPH + 6-Pyruvoyl-5,6,7,8-tetrahydro-pterin => 2 NADP+ + 5,6,7,8-Tetrahydro-biopterin( EC:1.1.1.153 ):multi-step reaction
xref_analog: EC:1.1.1.153
xref_analog: IMR:0200030
xref_analog: IMR:0200063
xref_analog: IMR:0200067
xref_analog: IMR:0200209
xref_analog: IMR:0200463
xref_analog: KEGG:R08208
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0002901
name: (S)-3-Hydroxy-3-methyl-glutaryl-CoA + CoA => Acetyl-CoA + Acetoacetyl-CoA + H2O( EC:2.3.3.10 )
xref_analog: EC:2.3.3.10
xref_analog: IMR:0200033
xref_analog: IMR:0200354
xref_analog: IMR:0200357
xref_analog: IMR:0200410
xref_analog: IMR:0200414
xref_analog: KEGG:map00072
xref_analog: KEGG:map00280
xref_analog: KEGG:map00650
xref_analog: KEGG:map00900
xref_analog: KEGG:R01978
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001427 ! Butanoate metabolism
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0002902
name: 2 3-Hydroxy-anthranilic acid + 4 O2 = Cinnavalininate + 2 O2.- + 2 H2O2 + 2 H+( EC:1.11.1.6 )
comment: 2 3-Hydroxy-anthranilic acid => Cinnavalininic acid( EC:1.11.1.6 ):\nnon-enzymatic\nmulti-step reaction\nthis reaction is hastened by superoxide dismutase (ec 1.15.1.1) and\ncatalase (ec 1.11.1.6)
xref_analog: EC:1.11.1.6
xref_analog: IMR:0200030
xref_analog: IMR:0200217
xref_analog: IMR:0200381
xref_analog: IMR:0200400
xref_analog: IMR:0200487
xref_analog: KEGG:C00704
xref_analog: KEGG:map00380
xref_analog: KEGG:R02670
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0002903
name: Lipoylprotein + Glycine => S-Aminomethyl-dihydro-lipoylprotein + CO2( EC:1.4.4.2 )
xref_analog: EC:1.4.4.2
xref_analog: IMR:0100118
xref_analog: IMR:0200324
xref_analog: IMR:0200336
xref_analog: IMR:0200377
xref_analog: KEGG:map00260
xref_analog: KEGG:R03425
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism

[Term]
id: IEV:0002904
name: CMP + H2O => Cytidine + Orthophosphate( EC:3.1.3.5 )
xref_analog: EC:3.1.3.5
xref_analog: IMR:0200102
xref_analog: IMR:0200161
xref_analog: IMR:0200357
xref_analog: IMR:0200494
xref_analog: KEGG:map00240
xref_analog: KEGG:R00511
is_a: IEV:0002751 ! 5'-ribonucleotide + H2O = ribonucleoside + phosphate( EC:3.1.3.5 )
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002905
name: 2-Amino-3-carboxy-muconate semialdehyde => 2,3-Pyridine-dicarboxylic acid + H2O( nonenzymatic )
xref_analog: IMR:0200192
xref_analog: IMR:0200357
xref_analog: IMR:0200460
xref_analog: KEGG:R04293
is_a: IEV:0002720 ! nonenzymatic reaction
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0002906
name: NAD+ + Acetaldehyde + H2O = NADH + Acetic acid + H+( EC:1.2.1.3 )
comment: NAD+ + Acetaldehyde + H2O = NADH + Acetic acid( EC:1.2.1.3 )
xref_analog: EC:1.2.1.3
xref_analog: IMR:0200030
xref_analog: IMR:0200208
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: IMR:0200373
xref_analog: IMR:0200521
xref_analog: KEGG:map00010
xref_analog: KEGG:map00620
xref_analog: KEGG:R00710
is_a: IEV:0002729 ! Aldehyde + NAD+ + H2O = Carboxylate + NADH + H+( EC:1.2.1.3 )
relationship: part_of IEV:0001424 ! Pyruvate metabolism

[Term]
id: IEV:0002907
name: ATP + Nucleoside diphosphate = ADP + Nucleoside triphosphate( EC:2.7.4.6 )
comment: general reaction
xref_analog: EC:2.7.4.6
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200499
xref_analog: KEGG:C00454
xref_analog: KEGG:R00331
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0002908
name: 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O =>  1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate + Orthophosphate ( EC:3.1.3.67 )
xref_analog: EC:3.1.3.67
xref_analog: IMR:0001350
xref_analog: IMR:0001352
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: KEGG:map00562
xref_analog: KEGG:map04070
xref_analog: KEGG:R04513
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0002909
name: beta-D-Fructose 1,6-bisphosphate = Dihydroxy-acetone phosphate + D-Glyceraldehyde 3-phosphate( EC:4.1.2.13 )
comment: D-Fructose 1,6-bisphosphate = Dihydroxy-acetone phosphate + D-Glyceraldehyde 3-phosphate( EC:4.1.2.13 )
xref_analog: EC:4.1.2.13
xref_analog: IMR:0200058
xref_analog: IMR:0200100
xref_analog: KEGG:C05378
xref_analog: KEGG:map00010
xref_analog: KEGG:map00030
xref_analog: KEGG:map00051
xref_analog: KEGG:R01070
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001413 ! Glycolysis and Gluconeogenesis
relationship: part_of IEV:0001414 ! Pentose phosphate pathway

[Term]
id: IEV:0002910
name: Succinyl-CoA + Enzyme N6-(dihydrolipoyl)lysine = CoA + [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine( EC:2.3.1.61 )
alt_id: IEV:0002740
comment: Succinyl-CoA + Dihydro-lipoamide = CoA + S-Succinyl-dihydro-lipoamide( EC:2.3.1.61 )
exact_synonym: "Succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine( EC:2.3.1.61 )" []
xref_analog: EC:2.3.1.61
xref_analog: IMR:0200037
xref_analog: IMR:0200354
xref_analog: KEGG:C15973
xref_analog: KEGG:C16254
xref_analog: KEGG:map00020
xref_analog: KEGG:R02570
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001415 ! Citrate cycle (TCA cycle)

[Term]
id: IEV:0002911
name: NAD+ + (S)-Malic acid = NADH + Pyruvic acid + CO2 + H+( EC:1.1.1.38 )
comment: NAD+ + (S)-Malic acid = NADH + Pyruvic acid + CO2( EC:1.1.1.38 )
xref_analog: EC:1.1.1.38
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200278
xref_analog: IMR:0200324
xref_analog: IMR:0200331
xref_analog: IMR:0200521
xref_analog: KEGG:map00620
xref_analog: KEGG:map00710
xref_analog: KEGG:R00214
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001424 ! Pyruvate metabolism

[Term]
id: IEV:0002912
name: (S)-2-Methylbutanoyl-CoA + Acceptor = 2-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.3 )
comment: 2-Methyl-butanoyl-CoA + Acceptor = 2-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.3 )
xref_analog: EC:1.3.99.3
xref_analog: IMR:0200224
xref_analog: IMR:0200300
xref_analog: IMR:0200465
xref_analog: KEGG:C15980
xref_analog: KEGG:map00280
xref_analog: KEGG:R03172
is_a: IEV:0002732 ! Acyl-CoA + Acceptor = 2,3-dehydroacyl-CoA + Reduced acceptor( EC:1.3.99.3 )
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0002913
name: ATP + L-Alanine + tRNA(Ala) => AMP + L-Alanyl-tRNA(Ala) + Pyrophosphate( EC:6.1.1.7 )
xref_analog: EC:6.1.1.7
xref_analog: IMR:0001351
xref_analog: IMR:0200083
xref_analog: IMR:0200095
xref_analog: IMR:0200244
xref_analog: IMR:0200251
xref_analog: IMR:0200280
xref_analog: KEGG:map00970
xref_analog: KEGG:R03038
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001410 ! Alanine and aspartate metabolism

[Term]
id: IEV:0002914
name: 2-Amino-3-carboxy-muconate semialdehyde => 2-Amino-muconate semialdehyde + CO2( EC:4.1.1.45 )
xref_analog: EC:4.1.1.45
xref_analog: IMR:0200192
xref_analog: IMR:0200324
xref_analog: IMR:0200424
xref_analog: KEGG:map00380
xref_analog: KEGG:R04323
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0002915
name: L-Serine => 2-Amino-acrylic acid + H2O( EC:4.3.1.17 )
xref_analog: EC:4.3.1.17
xref_analog: IMR:0200090
xref_analog: IMR:0200357
xref_analog: IMR:0200453
xref_analog: KEGG:map00270
xref_analog: KEGG:R00590
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism

[Term]
id: IEV:0002917
name: 5-Hydroxy-L-tryptophan => Serotonin + CO2( EC:4.1.1.28 )
xref_analog: EC:4.1.1.28
xref_analog: IMR:0100123
xref_analog: IMR:0200112
xref_analog: IMR:0200324
xref_analog: KEGG:map00380
xref_analog: KEGG:R02701
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0002918
name: 5(S)-HPETE => Leukotriene A4 + H2O( EC:1.13.11.34 )
comment: 5-HPETE => Leucotriene A4 + H2O( EC:1.13.11.34 )
xref_analog: EC:1.13.11.34
xref_analog: IMR:0200275
xref_analog: IMR:0200357
xref_analog: IMR:0200461
xref_analog: KEGG:map00590
xref_analog: KEGG:R03058
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0003851 ! Arachidonic acid + O2 = Leukotriene A4 + H2O( EC:1.13.11.34 )

[Term]
id: IEV:0002919
name: 1D-myo-Inositol 1-phosphate + H2O => myo-Inositol + Orthophosphate( EC:3.1.3.25 )
xref_analog: EC:3.1.3.25
xref_analog: IMR:0200102
xref_analog: IMR:0200177
xref_analog: IMR:0200357
xref_analog: IMR:0200476
xref_analog: KEGG:map00562
xref_analog: KEGG:map04070
xref_analog: KEGG:R01185
is_a: IEV:0002750 ! myo-inositol phosphate + H2O = myo-inositol + Orthophosphate( EC:3.1.3.25 )
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0002920
name: 2-Oxo-glutaric acid + L-Ornithine = L-Glutamic acid + L-Glutamate 5-semialdehyde( EC:2.6.1.13 )
comment: 2-Oxo-glutaric acid + N2-Succinyl-L-ornithine = L-Glutamic acid + N2-Succinyl-L-glutamate 5-semialdehyde( EC:2.6.1.13 )
xref_analog: EC:2.6.1.13
xref_analog: IMR:0100119
xref_analog: IMR:0200205
xref_analog: IMR:0200342
xref_analog: IMR:0200480
xref_analog: KEGG:map00330
xref_analog: KEGG:R00667
is_a: IEV:0002951 ! 2-Oxo acid + L-Ornithine = L-Amino acid + L-Glutamate 5-semialdehyde( EC:2.6.1.13 )
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0002921
name: S-Adenosyl-L-methionine + 3,4-Dihydroxy-mandelic acid => S-Adenosyl-L-homocysteine + 3-Methoxy-4-hydroxy-mandelic acid( EC:2.1.1.6 )
xref_analog: EC:2.1.1.6
xref_analog: IMR:0200054
xref_analog: IMR:0200068
xref_analog: IMR:0200151
xref_analog: IMR:0200152
xref_analog: KEGG:map00350
xref_analog: KEGG:R04887
is_a: IEV:0000433 ! Transmethylation
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0002922
name: Adenylo-succinic acid = AMP + Fumaric acid( EC:4.3.2.2 )
xref_analog: EC:4.3.2.2
xref_analog: IMR:0200083
xref_analog: IMR:0200115
xref_analog: IMR:0200186
xref_analog: KEGG:map00230
xref_analog: KEGG:map00250
xref_analog: KEGG:R01083
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001410 ! Alanine and aspartate metabolism
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002923
name: 5'-Phospho-ribosyl-4-(N-succino-carboxamide)-5-amino-imidazole = 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + Fumaric acid( EC:4.3.2.2 )
comment: 5'-Phospho-ribosyl-4-(N-succino-carboxamide)-5-amino-imidazole = 5'-Phospho-ribosyl-4-carboxamido-5-amino-imidazole + Fumaric acid( EC:4.3.2.2 )
xref_analog: EC:4.3.2.2
xref_analog: IMR:0200186
xref_analog: IMR:0200213
xref_analog: IMR:0200284
xref_analog: KEGG:map00230
xref_analog: KEGG:R04559
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002924
name: 3-Hydroxy-L-kynurenine + H2O => 3-Hydroxy-anthranilic acid + L-Alanine( EC:3.7.1.3 )
xref_analog: EC:3.7.1.3
xref_analog: IMR:0200066
xref_analog: IMR:0200251
xref_analog: IMR:0200357
xref_analog: IMR:0200400
xref_analog: KEGG:map00380
xref_analog: KEGG:R02668
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0002925
name: UTP + AMP = UDP + ADP( EC:2.7.4.10 )
xref_analog: EC:2.7.4.10
xref_analog: IMR:0001360
xref_analog: IMR:0200083
xref_analog: IMR:0200199
xref_analog: IMR:0200206
xref_analog: KEGG:map00240
xref_analog: KEGG:R00157
is_a: IEV:0002747 ! Nucleoside triphosphate + AMP = Nucleoside diphosphate + ADP( EC:2.7.4.10 )
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002926
name: Arachidonic acid + O2 => 15(S)-HPETE( EC:1.13.11.33 )
comment: Arachidonic acid + O2 => 15-HPETE( EC:1.13.11.33 )
xref_analog: EC:1.13.11.33
xref_analog: IMR:0200212
xref_analog: IMR:0200217
xref_analog: IMR:0200351
xref_analog: KEGG:map00590
xref_analog: KEGG:R01593
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001449 ! Arachidonic acid metabolism

[Term]
id: IEV:0002927
name: 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O => 1-Phosphatidyl-1D-myo-inositol 4 phosphate + Orthophosphate( EC:3.1.3.36 )
xref_analog: EC:3.1.3.36
xref_analog: IMR:0001350
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: IMR:0200496
xref_analog: KEGG:map00562
xref_analog: KEGG:map04070
xref_analog: KEGG:R04404
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0002928
name: NAD+ + (S)-Malic acid = NADH + Oxaloacetic acid + H+( EC:1.1.1.37 )
comment: NAD+ + (S)-Malic acid = NADH + Oxaloacetic acid( EC:1.1.1.37 )
xref_analog: EC:1.1.1.37
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200278
xref_analog: IMR:0200339
xref_analog: IMR:0200521
xref_analog: KEGG:map00020
xref_analog: KEGG:map00620
xref_analog: KEGG:map00630
xref_analog: KEGG:map00710
xref_analog: KEGG:map00720
xref_analog: KEGG:R00342
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001415 ! Citrate cycle (TCA cycle)

[Term]
id: IEV:0002929
name: ATP + Deoxy-cytidine => ADP + dCMP( EC:2.7.1.74 )
xref_analog: EC:2.7.1.74
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200005
xref_analog: IMR:0200390
xref_analog: KEGG:map00240
xref_analog: KEGG:R01666
is_a: IEV:0002746 ! Nucleoside triphosphate + deoxycytidine = Nucleoside diphosphate + dCMP( EC:2.7.1.74 )
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002930
name: L-Homocysteine + Betaine => L-Methionine + N,N-Dimethyl-glycine( EC:2.1.1.5 )
xref_analog: EC:2.1.1.5
xref_analog: IMR:0200039
xref_analog: IMR:0200047
xref_analog: IMR:0200233
xref_analog: IMR:0200488
xref_analog: KEGG:map00260
xref_analog: KEGG:map00270
xref_analog: KEGG:R02821
is_a: IEV:0000433 ! Transmethylation
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism
relationship: part_of IEV:0001466 ! Methionine and Cysteine metabolism

[Term]
id: IEV:0002931
name: L-Arginine + H2O => L-Ornithine + Urea( EC:3.5.3.1 )
xref_analog: EC:3.5.3.1
xref_analog: IMR:0200111
xref_analog: IMR:0200342
xref_analog: IMR:0200357
xref_analog: IMR:0200428
xref_analog: KEGG:map00330
xref_analog: KEGG:R00551
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0002932
name: beta-D-Glucose 6-phosphate = beta-D-Fructose 6-phosphate( EC:5.3.1.9 )
comment: D-Glucose 6-phosphate = D-Fructose 6-phosphate( EC:5.3.1.9 )
xref_analog: EC:5.3.1.9
xref_analog: KEGG:C01172
xref_analog: KEGG:C05345
xref_analog: KEGG:map00010
xref_analog: KEGG:R03321
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001413 ! Glycolysis and Gluconeogenesis

[Term]
id: IEV:0002933
name: (S)-2-Methylbutanoyl-CoA + Acceptor = 2-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.2 )
comment: 2-Methyl-butanoyl-CoA + Acceptor = 2-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.2 )
xref_analog: EC:1.3.99.2
xref_analog: IMR:0200224
xref_analog: IMR:0200300
xref_analog: IMR:0200465
xref_analog: KEGG:C15980
xref_analog: KEGG:map00280
xref_analog: KEGG:R03172
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0002934
name: NAD+ + L-Saccharopine + H2O = NADH + L-2-Amino-adipate 6-semialdehyde + L-Glutamic acid + H+( EC:1.5.1.9 )
comment: NAD+ + L-Saccharopine + H2O = NADH + L-2-Amino-adipate 6-semialdehyde + L-Glutamic acid( EC:1.5.1.9 )
xref_analog: EC:1.5.1.9
xref_analog: IMR:0100119
xref_analog: IMR:0200030
xref_analog: IMR:0200155
xref_analog: IMR:0200248
xref_analog: IMR:0200294
xref_analog: IMR:0200357
xref_analog: IMR:0200521
xref_analog: KEGG:map00310
xref_analog: KEGG:R02313
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001457 ! Lysine degradation

[Term]
id: IEV:0002935
name: Squalene + O2 + NADPH + H+ => (S)-2,3-Epoxy-squalene + H2O + NADP+( EC:1.14.99.7 )
comment: Squalene + O2 + Reduced acceptor => (S)-2,3-Epoxy-squalene + H2O + Acceptor( EC:1.14.99.7 )
xref_analog: EC:1.14.99.7
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200463
xref_analog: IMR:0200481
xref_analog: IMR:0200509
xref_analog: KEGG:map00100
xref_analog: KEGG:R02874
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001443 ! Steroid biosynthesis

[Term]
id: IEV:0002936
name: GTP => 3',5'-Cyclic GMP + Pyrophosphate( EC:4.6.1.2 )
xref_analog: EC:4.6.1.2
xref_analog: IMR:0001354
xref_analog: IMR:0100025
xref_analog: IMR:0200280
xref_analog: KEGG:map00230
xref_analog: KEGG:R00434
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002937
name: D-Ribose 1-phosphate = D-Ribose 5-phosphate( EC:5.4.2.2 )
xref_analog: EC:5.4.2.2
xref_analog: IMR:0200060
xref_analog: KEGG:C00620
xref_analog: KEGG:map00030
xref_analog: KEGG:map00230
xref_analog: KEGG:R01057
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001414 ! Pentose phosphate pathway

[Term]
id: IEV:0002938
name: myo-Inositol + O2 => D-Glucuronic acid + H2O( EC:1.13.99.1 )
xref_analog: EC:1.13.99.1
xref_analog: IMR:0200015
xref_analog: IMR:0200177
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: KEGG:map00053
xref_analog: KEGG:map00562
xref_analog: KEGG:R01184
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0002939
name: 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine => 4-Trimethyl-ammonio-butanal + Glycine( EC:4.1.2.- )
comment: 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine => 4-Trimethyl-ammonio-butanal + Glycine( EC:2.1.2.1 )
xref_analog: EC:4.1.2.-
xref_analog: IMR:0100118
xref_analog: IMR:0200070
xref_analog: IMR:0200493
xref_analog: KEGG:map00310
xref_analog: KEGG:R03284
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001457 ! Lysine degradation

[Term]
id: IEV:0002940
name: ATP + dCMP = ADP + dCDP( EC:2.7.4.14 )
xref_analog: EC:2.7.4.14
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200005
xref_analog: IMR:0200078
xref_analog: KEGG:map00240
xref_analog: KEGG:R01665
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002941
name: Deoxy-inosine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Hypoxanthine( EC:2.4.2.4 )
xref_analog: EC:2.4.2.4
xref_analog: IMR:0200048
xref_analog: IMR:0200102
xref_analog: IMR:0200173
xref_analog: IMR:0200197
xref_analog: KEGG:map00230
xref_analog: KEGG:R02748
is_a: IEV:0002560 ! Glycosylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002942
name: CoA + ATP + Succinic acid = Succinyl-CoA + ADP + Orthophosphate( EC:6.2.1.5 )
xref_analog: EC:6.2.1.5
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200037
xref_analog: IMR:0200102
xref_analog: IMR:0200119
xref_analog: IMR:0200354
xref_analog: KEGG:map00020
xref_analog: KEGG:map00640
xref_analog: KEGG:map00720
xref_analog: KEGG:R00405
is_a: IEV:0000394 ! CoA ligation
relationship: part_of IEV:0001415 ! Citrate cycle (TCA cycle)

[Term]
id: IEV:0002943
name: ATP + L-Tryptophan + tRNA(Trp) => AMP + L-Tryptophanyl-tRNA(Trp) + Pyrophosphate( EC:6.1.1.2 )
xref_analog: EC:6.1.1.2
xref_analog: IMR:0001351
xref_analog: IMR:0200083
xref_analog: IMR:0200260
xref_analog: IMR:0200280
xref_analog: IMR:0200306
xref_analog: IMR:0200307
xref_analog: KEGG:map00380
xref_analog: KEGG:map00970
xref_analog: KEGG:R03664
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0002944
name: 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate = 5'-Phospho-ribosyl-5-amino-imidazole + CO2( EC:4.1.1.21 )
comment: 5'-Phospho-ribosyl-5-amino-imidazole-4-carboxylic acid = 5'-Phospho-ribosyl-5-amino-imidazole + CO2( EC:4.1.1.21 )
xref_analog: EC:4.1.1.21
xref_analog: IMR:0200324
xref_analog: IMR:0200422
xref_analog: IMR:0200513
xref_analog: KEGG:map00230
xref_analog: KEGG:R04209
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002945
name: Choloyl-CoA + Taurine = CoA + Taurocholic acid( EC:2.3.1.65 )
xref_analog: EC:2.3.1.65
xref_analog: IMR:0100120
xref_analog: IMR:0200004
xref_analog: IMR:0200138
xref_analog: IMR:0200354
xref_analog: KEGG:map00120
xref_analog: KEGG:map00430
xref_analog: KEGG:R03720
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001466 ! Methionine and Cysteine metabolism

[Term]
id: IEV:0002946
name: NAD+ + L-Glutamic acid + H2O = NADH + 2-Oxo-glutaric acid + NH3 + H+( EC:1.4.1.3 )
comment: NAD+ + L-Glutamic acid + H2O = NADH + 2-Oxo-glutaric acid + NH3( EC:1.4.1.3 )
xref_analog: EC:1.4.1.3
xref_analog: IMR:0100119
xref_analog: IMR:0200030
xref_analog: IMR:0200075
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: IMR:0200480
xref_analog: IMR:0200521
xref_analog: KEGG:map00250
xref_analog: KEGG:map00330
xref_analog: KEGG:map00471
xref_analog: KEGG:map00910
xref_analog: KEGG:R00243
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001411 ! Glutamate metabolism
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0002947
name: D-Fructose 1-phosphate = Dihydroxy-acetone phosphate + D-Glyceraldehyde( EC:4.1.2.13 )
xref_analog: EC:4.1.2.13
xref_analog: IMR:0200100
xref_analog: IMR:0200120
xref_analog: IMR:0200167
xref_analog: KEGG:map00051
xref_analog: KEGG:R02568
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001417 ! Fructose and mannose metabolism

[Term]
id: IEV:0002948
name: D-Glucose 1-phosphate = alpha-D-Glucose 6-phosphate( EC:5.4.2.2 )
comment: D-Glucose 1-phosphate = D-Glucose 6-phosphate( EC:5.4.2.2 )
xref_analog: EC:5.4.2.2
xref_analog: IMR:0200190
xref_analog: KEGG:C00668
xref_analog: KEGG:map00010
xref_analog: KEGG:map00052
xref_analog: KEGG:map00500
xref_analog: KEGG:map00520
xref_analog: KEGG:R00959
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001413 ! Glycolysis and Gluconeogenesis

[Term]
id: IEV:0002949
name: NAD+ + 3-Methoxy-4-hydroxy-phenyl-glycolaldehyde + H2O = NADH + 3-Methoxy-4-hydroxy-mandelic acid + H+( EC:1.2.1.5 )
comment: NAD+ + 3-Methoxy-4-hydroxy-phenyl-glycolaldehyde + H2O = NADH + 3-Methoxy-4-hydroxy-mandelic acid( EC:1.2.1.5 )
xref_analog: EC:1.2.1.5
xref_analog: IMR:0200030
xref_analog: IMR:0200152
xref_analog: IMR:0200171
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: IMR:0200521
xref_analog: KEGG:map00350
xref_analog: KEGG:R04891
is_a: IEV:0002730 ! Aldehyde + NADP+ + H2O = Carboxylate + NADPH + H+( EC:1.2.1.5 )
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0002950
name: 1D-myo-Inositol 1,4-bisphosphate + H2O => 1D-myo-Inositol 4-phosphate + Orthophosphate( EC:3.1.3.57 )
xref_analog: EC:3.1.3.57
xref_analog: IMR:0100698
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: IMR:0200419
xref_analog: KEGG:map00562
xref_analog: KEGG:map04070
xref_analog: KEGG:R03393
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0002951
name: 2-Oxo acid + L-Ornithine = L-Amino acid + L-Glutamate 5-semialdehyde( EC:2.6.1.13 )
xref_analog: EC:2.6.1.13
xref_analog: IMR:0200205
xref_analog: IMR:0200342
xref_analog: KEGG:C00151
xref_analog: KEGG:C00161
xref_analog: KEGG:R01343
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0002952
name: L-Normetanephrine + H2O + O2 => 3-Methoxy-4-hydroxy-phenyl-glycolaldehyde + NH3 + H2O2( EC:1.4.3.4 )
xref_analog: EC:1.4.3.4
xref_analog: IMR:0200075
xref_analog: IMR:0200171
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200388
xref_analog: IMR:0200487
xref_analog: KEGG:map00350
xref_analog: KEGG:R04893
is_a: IEV:0002734 ! Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.4 )
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0002953
name: ATP + CDP = ADP + CTP( EC:2.7.4.6 )
xref_analog: EC:2.7.4.6
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200202
xref_analog: IMR:0200468
xref_analog: KEGG:map00240
xref_analog: KEGG:R00570
is_a: IEV:0002907 ! ATP + Nucleoside diphosphate = ADP + Nucleoside triphosphate( EC:2.7.4.6 )
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002954
name: (S)-3-Hydroxy-3-methyl-glutaryl-CoA = 3-Methyl-glutaconyl-CoA + H2O( EC:4.2.1.18 )
xref_analog: EC:4.2.1.18
xref_analog: IMR:0200033
xref_analog: IMR:0200069
xref_analog: IMR:0200357
xref_analog: KEGG:map00280
xref_analog: KEGG:R02085
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0002955
name: 4-Fumaryl-acetoacetic acid + H2O => Fumaric acid + Acetoacetic acid( EC:3.7.1.2 )
xref_analog: EC:3.7.1.2
xref_analog: IMR:0200064
xref_analog: IMR:0200186
xref_analog: IMR:0200357
xref_analog: IMR:0200507
xref_analog: KEGG:map00350
xref_analog: KEGG:map00643
xref_analog: KEGG:R01364
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0002956
name: beta-D-Fructose 1,6-bisphosphate + H2O => beta-D-Fructose 6-phosphate + Orthophosphate( EC:3.1.3.11 )
comment: D-Fructose 1,6-bisphosphate + H2O => D-Fructose 6-phosphate + Orthophosphate( EC:3.1.3.11 )
xref_analog: EC:3.1.3.11
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: KEGG:C05345
xref_analog: KEGG:C05378
xref_analog: KEGG:map00010
xref_analog: KEGG:map00030
xref_analog: KEGG:map00051
xref_analog: KEGG:R04780
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001413 ! Glycolysis and Gluconeogenesis
relationship: part_of IEV:0001414 ! Pentose phosphate pathway

[Term]
id: IEV:0002957
name: N-Acetyl-D-glucosamine = N-Acetyl-D-mannosamine( EC:5.1.3.8 )
xref_analog: EC:5.1.3.8
xref_analog: IMR:0200282
xref_analog: IMR:0200374
xref_analog: KEGG:map00520
xref_analog: KEGG:R01207
is_a: IEV:0002760 ! N-acyl-D-glucosamine = N-acyl-D-mannosamine( EC:5.1.3.8 )
relationship: part_of IEV:0001421 ! Aminosugars metabolism

[Term]
id: IEV:0002958
name: GDP + H2O => GMP + Orthophosphate( EC:3.6.1.5 )
xref_analog: EC:3.6.1.5
xref_analog: IMR:0001357
xref_analog: IMR:0200102
xref_analog: IMR:0200292
xref_analog: IMR:0200357
xref_analog: KEGG:map00230
xref_analog: KEGG:R00328
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002959
name: IDP + H2O => IMP + Orthophosphate( EC:3.6.1.6 )
xref_analog: EC:3.6.1.6
xref_analog: IMR:0200102
xref_analog: IMR:0200221
xref_analog: IMR:0200357
xref_analog: IMR:0200511
xref_analog: KEGG:map00230
xref_analog: KEGG:R00961
is_a: IEV:0002756 ! nucleoside diphosphate + H2O = nucleotide + Orthophosphate( EC:3.6.1.6 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002960
name: ATP + Sulfuric acid => Adenosine-5'-phospho-sulfate + Pyrophosphate( EC:2.7.7.4 )
xref_analog: EC:2.7.7.4
xref_analog: IMR:0001351
xref_analog: IMR:0200032
xref_analog: IMR:0200232
xref_analog: IMR:0200280
xref_analog: KEGG:map00230
xref_analog: KEGG:R00529
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002961
name: UTP + N-Acetyl-alpha-D-glucosamine 1-phosphate = Pyrophosphate + UDP-N-acetyl-D-glucosamine( EC:2.7.7.23 )
comment: UTP + N-Acetyl-D-glucosamine 1-phosphate = Pyrophosphate + UDP-N-acetyl-D-glucosamine( EC:2.7.7.23 )
xref_analog: EC:2.7.7.23
xref_analog: IMR:0200199
xref_analog: IMR:0200247
xref_analog: IMR:0200280
xref_analog: KEGG:C04501
xref_analog: KEGG:map00520
xref_analog: KEGG:R00416
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001421 ! Aminosugars metabolism

[Term]
id: IEV:0002962
name: 2 Acetyl-CoA = CoA + Acetoacetyl-CoA( EC:2.3.1.9 )
xref_analog: EC:2.3.1.9
xref_analog: IMR:0200354
xref_analog: IMR:0200410
xref_analog: IMR:0200414
xref_analog: KEGG:map00071
xref_analog: KEGG:map00072
xref_analog: KEGG:map00280
xref_analog: KEGG:map00310
xref_analog: KEGG:map00380
xref_analog: KEGG:map00620
xref_analog: KEGG:map00632
xref_analog: KEGG:map00640
xref_analog: KEGG:map00650
xref_analog: KEGG:map00900
xref_analog: KEGG:R00238
is_a: IEV:0002399 ! Transacetylation
relationship: part_of IEV:0001427 ! Butanoate metabolism
relationship: part_of IEV:0001457 ! Lysine degradation
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0002963
name: Malonyl-CoA = Acetyl-CoA + CO2( EC:4.1.1.9 )
xref_analog: EC:4.1.1.9
xref_analog: IMR:0200324
xref_analog: IMR:0200414
xref_analog: IMR:0200464
xref_analog: KEGG:map00410
xref_analog: KEGG:map00640
xref_analog: KEGG:R00233
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001424 ! Pyruvate metabolism

[Term]
id: IEV:0002964
name: GTP + IMP + L-Aspartic acid => GDP + Adenylo-succinic acid + Orthophosphate( EC:6.3.4.4 )
xref_analog: EC:6.3.4.4
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: IMR:0200102
xref_analog: IMR:0200115
xref_analog: IMR:0200221
xref_analog: IMR:0200459
xref_analog: KEGG:map00230
xref_analog: KEGG:map00250
xref_analog: KEGG:R01135
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001410 ! Alanine and aspartate metabolism
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002965
name: ADP + Reduced thioredoxin => dADP + H2O + Oxidized thioredoxin( EC:1.17.4.1 )
xref_analog: EC:1.17.4.1
xref_analog: IMR:0001360
xref_analog: IMR:0200108
xref_analog: IMR:0200133
xref_analog: IMR:0200237
xref_analog: IMR:0200357
xref_analog: KEGG:map00230
xref_analog: KEGG:R02017
is_a: IEV:0002728 ! 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin( EC:1.17.4.1 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002966
name: ATP + dUMP = ADP + dUDP( EC:2.7.4.9 )
xref_analog: EC:2.7.4.9
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200008
xref_analog: IMR:0200098
xref_analog: KEGG:map00240
xref_analog: KEGG:R02098
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002967
name: Thymidine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Thymine( EC:2.4.2.4 )
xref_analog: EC:2.4.2.4
xref_analog: IMR:0200036
xref_analog: IMR:0200048
xref_analog: IMR:0200102
xref_analog: IMR:0200384
xref_analog: KEGG:map00240
xref_analog: KEGG:R01570
is_a: IEV:0002560 ! Glycosylation
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002968
name: Arachidonic acid + O2 => 5(S)-HPETE( EC:1.13.11.34 )
comment: Arachidonic acid + O2 => 5-HPETE( EC:1.13.11.34 ):subsequently IEV:0002918
xref_analog: EC:1.13.11.34
xref_analog: IMR:0200212
xref_analog: IMR:0200217
xref_analog: IMR:0200275
xref_analog: KEGG:map00590
xref_analog: KEGG:R01595
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0003851 ! Arachidonic acid + O2 = Leukotriene A4 + H2O( EC:1.13.11.34 )

[Term]
id: IEV:0002969
name: ITP + H2O => IMP + Pyrophosphate( EC:3.6.1.19 )
xref_analog: EC:3.6.1.19
xref_analog: IMR:0200074
xref_analog: IMR:0200221
xref_analog: IMR:0200280
xref_analog: IMR:0200357
xref_analog: KEGG:map00230
xref_analog: KEGG:R00720
is_a: IEV:0002755 ! Nucleoside triphosphate + H2O = Nucleotide + diphosphate( EC:3.6.1.19 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002970
name: Deoxy-cytidine + H2O => Deoxy-uridine + NH3( EC:3.5.4.5 )
xref_analog: EC:3.5.4.5
xref_analog: IMR:0200075
xref_analog: IMR:0200103
xref_analog: IMR:0200357
xref_analog: IMR:0200390
xref_analog: KEGG:map00240
xref_analog: KEGG:R02485
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002971
name: 3-Ureidopropionate + H2O => beta-Alanine + CO2 + NH3( EC:3.5.1.6 )
comment: Ureido-propanoic acid + H2O => beta-Alanine + CO2 + NH3( EC:3.5.1.6 )
xref_analog: EC:3.5.1.6
xref_analog: IMR:0200075
xref_analog: IMR:0200276
xref_analog: IMR:0200324
xref_analog: IMR:0200357
xref_analog: IMR:0200438
xref_analog: KEGG:map00240
xref_analog: KEGG:map00410
xref_analog: KEGG:map00770
xref_analog: KEGG:R00905
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002972
name: ATP + L-Fucose = ADP + L-Fucose 1-phosphate( EC:2.7.1.52 )
xref_analog: EC:2.7.1.52
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200101
xref_analog: IMR:0200303
xref_analog: KEGG:map00051
xref_analog: KEGG:map00520
xref_analog: KEGG:R03161
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001417 ! Fructose and mannose metabolism

[Term]
id: IEV:0002973
name: 5-Phospho-alpha-D-ribose 1-diphosphate + 2,3-Pyridine-dicarboxylic acid => Nicotinate D-ribonucleotide + Pyrophosphate + CO2( EC:2.4.2.19 )
comment: D-5-Phospho-ribosyl 1-diphosphate + 2,3-Pyridine-dicarboxylic acid => Nicotinate D-ribonucleotide + Pyrophosphate + CO2( EC:2.4.2.19 )
xref_analog: EC:2.4.2.19
xref_analog: IMR:0200179
xref_analog: IMR:0200262
xref_analog: IMR:0200280
xref_analog: IMR:0200324
xref_analog: IMR:0200460
xref_analog: KEGG:map00760
xref_analog: KEGG:R03348
is_a: IEV:0002560 ! Glycosylation
relationship: part_of IEV:0001510 ! Nicotinate and nicotinamide metabolism

[Term]
id: IEV:0002974
name: S-Adenosyl-L-methionine + Guanidino-acetic acid => S-Adenosyl-L-homocysteine + Creatine( EC:2.1.1.2 )
xref_analog: EC:2.1.1.2
xref_analog: IMR:0200054
xref_analog: IMR:0200144
xref_analog: IMR:0200151
xref_analog: IMR:0200413
xref_analog: KEGG:map00260
xref_analog: KEGG:map00330
xref_analog: KEGG:R01883
is_a: IEV:0000433 ! Transmethylation
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0002975
name: 5-Hydroxy-kynurenine => 5-Hydroxy-kynurenamine + CO2( EC:4.1.1.28 )
xref_analog: EC:4.1.1.28
xref_analog: IMR:0200324
xref_analog: IMR:0200491
xref_analog: IMR:0200500
xref_analog: KEGG:map00380
xref_analog: KEGG:R04909
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0002976
name: NADP+ + GDP-L-fucose = NADPH + GDP-4-dehydro-6-deoxy-D-mannose + H+( EC:1.1.1.271 )
comment: NADP+ + GDP-L-fucose = NADPH + GDP-4-dehydro-6-deoxy-D-mannose( EC:1.1.1.271 )
xref_analog: EC:1.1.1.271
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200150
xref_analog: IMR:0200463
xref_analog: IMR:0200472
xref_analog: KEGG:map00051
xref_analog: KEGG:map00520
xref_analog: KEGG:R05692
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001417 ! Fructose and mannose metabolism

[Term]
id: IEV:0002977
name: NADPH + L-Lysine + 2-Oxo-glutaric acid + H+ => NADP+ + L-Saccharopine + H2O( EC:1.5.1.8 )
comment: NADPH + L-Lysine + 2-Oxo-glutaric acid => NADP+ + L-Saccharopine + H2O( EC:1.5.1.8 )
xref_analog: EC:1.5.1.8
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200140
xref_analog: IMR:0200155
xref_analog: IMR:0200357
xref_analog: IMR:0200463
xref_analog: IMR:0200480
xref_analog: KEGG:map00300
xref_analog: KEGG:map00310
xref_analog: KEGG:R00716
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001457 ! Lysine degradation

[Term]
id: IEV:0002978
name: ATP + dIDP = ADP + dITP( EC:2.7.4.6 )
xref_analog: EC:2.7.4.6
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200073
xref_analog: IMR:0200122
xref_analog: KEGG:map00230
xref_analog: KEGG:R03530
is_a: IEV:0002907 ! ATP + Nucleoside diphosphate = ADP + Nucleoside triphosphate( EC:2.7.4.6 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002979
name: alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate( EC:3.1.3.9 )
comment: D-Glucose 6-phosphate + H2O => D-Glucose + Orthophosphate( EC:3.1.3.9 )
xref_analog: EC:3.1.3.9
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: KEGG:C00267
xref_analog: KEGG:C00668
xref_analog: KEGG:map00010
xref_analog: KEGG:map00052
xref_analog: KEGG:map00500
xref_analog: KEGG:R01788
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001413 ! Glycolysis and Gluconeogenesis

[Term]
id: IEV:0002980
name: L-Cysteine-sulfinic acid => Hypotaurine + CO2( EC:4.1.1.29 )
xref_analog: EC:4.1.1.29
xref_analog: IMR:0200305
xref_analog: IMR:0200324
xref_analog: IMR:0200402
xref_analog: KEGG:map00430
xref_analog: KEGG:R02466
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001466 ! Methionine and Cysteine metabolism

[Term]
id: IEV:0002981
name: L-Serine + Pyruvic acid = Hydroxy-pyruvic acid + L-Alanine( EC:2.6.1.51 )
xref_analog: EC:2.6.1.51
xref_analog: IMR:0200251
xref_analog: IMR:0200331
xref_analog: IMR:0200453
xref_analog: IMR:0200470
xref_analog: KEGG:map00260
xref_analog: KEGG:R00585
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism

[Term]
id: IEV:0002982
name: Pyridoxamine + O2 + H2O => Pyridoxal + H2O2 + NH3( EC:1.4.3.5 )
xref_analog: EC:1.4.3.5
xref_analog: IMR:0200075
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200382
xref_analog: IMR:0200487
xref_analog: IMR:0200504
xref_analog: KEGG:map00750
xref_analog: KEGG:R01710
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001509 ! Vitamin B6 metabolism

[Term]
id: IEV:0002983
name: D-Mannose 1-phosphate = D-Mannose 6-phosphate( EC:5.4.2.8 )
xref_analog: EC:5.4.2.8
xref_analog: IMR:0200053
xref_analog: IMR:0200327
xref_analog: KEGG:map00051
xref_analog: KEGG:map00520
xref_analog: KEGG:R01818
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001417 ! Fructose and mannose metabolism

[Term]
id: IEV:0002984
name: Nicotinate D-ribonucleotide + ATP = Deamido-NAD+ + Pyrophosphate( EC:2.7.7.1 )
xref_analog: EC:2.7.7.1
xref_analog: IMR:0001351
xref_analog: IMR:0200082
xref_analog: IMR:0200262
xref_analog: IMR:0200280
xref_analog: KEGG:map00760
xref_analog: KEGG:R03005
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001510 ! Nicotinate and nicotinamide metabolism

[Term]
id: IEV:0002985
name: NAD+ + D-Glycerate 3-phosphate = NADH + 3-Phospho-hydroxy-pyruvic acid + H+( EC:1.1.1.95 )
comment: NAD+ + D-Glycerate 3-phosphate = NADH + 3-Phospho-hydroxy-pyruvic acid( EC:1.1.1.95 )
xref_analog: EC:1.1.1.95
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200320
xref_analog: IMR:0200329
xref_analog: IMR:0200521
xref_analog: KEGG:map00260
xref_analog: KEGG:R01513
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism

[Term]
id: IEV:0002986
name: N-Acetyl-D-mannosamine + Phosphoenol-pyruvic acid + H2O => N-Acetyl-neuraminic acid + Orthophosphate( EC:2.5.1.56 )
xref_analog: EC:2.5.1.56
xref_analog: IMR:0200020
xref_analog: IMR:0200102
xref_analog: IMR:0200223
xref_analog: IMR:0200282
xref_analog: IMR:0200357
xref_analog: KEGG:map00520
xref_analog: KEGG:R01804
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001421 ! Aminosugars metabolism

[Term]
id: IEV:0002987
name: NAD+ + 5-Hydroxy-indole-acetaldehyde + H2O => NADH + 5-Hydroxy-indole-acetic acid + H+( EC:1.2.1.3 )
comment: NAD+ + 5-Hydroxy-indole-acetaldehyde + H2O => NADH + 5-Hydroxy-indole-acetic acid( EC:1.2.1.3 )
xref_analog: EC:1.2.1.3
xref_analog: IMR:0200030
xref_analog: IMR:0200052
xref_analog: IMR:0200248
xref_analog: IMR:0200353
xref_analog: IMR:0200357
xref_analog: IMR:0200521
xref_analog: KEGG:map00380
xref_analog: KEGG:R04903
is_a: IEV:0002729 ! Aldehyde + NAD+ + H2O = Carboxylate + NADH + H+( EC:1.2.1.3 )
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0002988
name: Adenosine + Orthophosphate = Adenine + D-Ribose 1-phosphate( EC:2.4.2.1 )
xref_analog: EC:2.4.2.1
xref_analog: IMR:0100126
xref_analog: IMR:0200102
xref_analog: IMR:0200350
xref_analog: KEGG:C00620
xref_analog: KEGG:map00230
xref_analog: KEGG:R01561
is_a: IEV:0002742 ! purine nucleoside + Orthophosphate = purine + D-ribose 1-phosphate( EC:2.4.2.1 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0002989
name: beta-D-Fructose 6-phosphate + D-Glyceraldehyde 3-phosphate = D-Erythrose 4-phosphate + D-Xylulose 5-phosphate( EC:2.2.1.1 )
comment: D-Fructose 6-phosphate + D-Glyceraldehyde 3-phosphate = D-Erythrose 4-phosphate + D-Xylulose 5-phosphate( EC:2.2.1.1 )
xref_analog: EC:2.2.1.1
xref_analog: IMR:0200012
xref_analog: IMR:0200058
xref_analog: IMR:0200169
xref_analog: KEGG:C05345
xref_analog: KEGG:map00030
xref_analog: KEGG:R01830
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001414 ! Pentose phosphate pathway

[Term]
id: IEV:0002990
name: GDP + D-Mannose 1-phosphate => GDP-D-mannose + Orthophosphate( EC:2.7.7.22 )
xref_analog: EC:2.7.7.22
xref_analog: IMR:0001357
xref_analog: IMR:0200102
xref_analog: IMR:0200327
xref_analog: IMR:0200451
xref_analog: KEGG:map00051
xref_analog: KEGG:map00520
xref_analog: KEGG:R00883
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001417 ! Fructose and mannose metabolism

[Term]
id: IEV:0002991
name: NAD+ + 2-Propyn-1-al + H2O = NADH + Propiolic acid + H+( EC:1.2.1.3 )
comment: NAD+ + 2-Propyn-1-al + H2O = NADH + Propiolic acid( EC:1.2.1.3 )
xref_analog: EC:1.2.1.3
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: IMR:0200371
xref_analog: IMR:0200503
xref_analog: IMR:0200521
xref_analog: KEGG:map00640
xref_analog: KEGG:R02940
is_a: IEV:0002729 ! Aldehyde + NAD+ + H2O = Carboxylate + NADH + H+( EC:1.2.1.3 )
relationship: part_of IEV:0001426 ! Propanoate metabolism

[Term]
id: IEV:0002992
name: ATP + dTDP = ADP + dTTP( EC:2.7.4.6 )
xref_analog: EC:2.7.4.6
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200084
xref_analog: IMR:0200338
xref_analog: KEGG:map00240
xref_analog: KEGG:R02093
is_a: IEV:0002907 ! ATP + Nucleoside diphosphate = ADP + Nucleoside triphosphate( EC:2.7.4.6 )
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002993
name: dCMP + H2O => dUMP + NH3( EC:3.5.4.12 )
xref_analog: EC:3.5.4.12
xref_analog: IMR:0200005
xref_analog: IMR:0200008
xref_analog: IMR:0200075
xref_analog: IMR:0200357
xref_analog: KEGG:map00240
xref_analog: KEGG:R01663
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0002994
name: cis-Aconitic acid + H2O = Isocitric acid( EC:4.2.1.3 )
xref_analog: EC:4.2.1.3
xref_analog: IMR:0200023
xref_analog: IMR:0200271
xref_analog: IMR:0200357
xref_analog: KEGG:map00020
xref_analog: KEGG:map00630
xref_analog: KEGG:map00720
xref_analog: KEGG:R01900
relationship: part_of IEV:0003326 ! Citric acid = Isocitric acid( EC:4.2.1.3 )

[Term]
id: IEV:0002995
name: 2-Oxo-glutaric acid + 4-Amino-butanoic acid = L-Glutamic acid + Succinate semialdehyde( EC:2.6.1.19 )
xref_analog: EC:2.6.1.19
xref_analog: IMR:0100117
xref_analog: IMR:0100119
xref_analog: IMR:0200454
xref_analog: IMR:0200480
xref_analog: KEGG:map00250
xref_analog: KEGG:map00650
xref_analog: KEGG:R01648
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001411 ! Glutamate metabolism

[Term]
id: IEV:0002996
name: ATP + L-Arginine + tRNA(Arg) => AMP + L-Arginyl-tRNA(Arg) + Pyrophosphate( EC:6.1.1.19 )
xref_analog: EC:6.1.1.19
xref_analog: IMR:0001351
xref_analog: IMR:0200072
xref_analog: IMR:0200083
xref_analog: IMR:0200280
xref_analog: IMR:0200366
xref_analog: IMR:0200428
xref_analog: KEGG:map00970
xref_analog: KEGG:R03646
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0002997
name: L-Alanine + Glyoxylic acid = Pyruvic acid + Glycine( EC:2.6.1.44 )
xref_analog: EC:2.6.1.44
xref_analog: IMR:0100118
xref_analog: IMR:0200184
xref_analog: IMR:0200251
xref_analog: IMR:0200331
xref_analog: KEGG:map00250
xref_analog: KEGG:R00369
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001410 ! Alanine and aspartate metabolism

[Term]
id: IEV:0002998
name: 2-Oxo-glutaric acid + L-Valine = L-Glutamic acid + 3-Methyl-2-oxo-butanoic acid( EC:2.6.1.42 )
xref_analog: EC:2.6.1.42
xref_analog: IMR:0100119
xref_analog: IMR:0200088
xref_analog: IMR:0200480
xref_analog: IMR:0200501
xref_analog: KEGG:map00280
xref_analog: KEGG:map00290
xref_analog: KEGG:map00770
xref_analog: KEGG:map00966
xref_analog: KEGG:R01214
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0002999
name: (R)-S-Lactoyl-glutathione = Glutathione + Methyl-glyoxal( EC:4.4.1.5 )
xref_analog: EC:4.4.1.5
xref_analog: IMR:0002043
xref_analog: IMR:0200318
xref_analog: IMR:0200471
xref_analog: KEGG:map00620
xref_analog: KEGG:R02530
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001424 ! Pyruvate metabolism

[Term]
id: IEV:0003000
name: L-Glutamine + H2O = L-Glutamic acid + NH3( EC:3.5.1.2 )
xref_analog: EC:3.5.1.2
xref_analog: IMR:0100119
xref_analog: IMR:0200075
xref_analog: IMR:0200357
xref_analog: IMR:0200448
xref_analog: KEGG:map00250
xref_analog: KEGG:map00330
xref_analog: KEGG:map00471
xref_analog: KEGG:map00910
xref_analog: KEGG:R00256
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001411 ! Glutamate metabolism

[Term]
id: IEV:0003001
name: NAD+ + L-4-Hydroxy-glutamate semialdehyde + H2O => NADH + L-erythro-4-Hydroxy-glutamic acid + H+( EC:1.5.1.12 )
comment: NAD+ + L-4-Hydroxy-glutamate semialdehyde + H2O => NADH + L-erythro-4-Hydroxy-glutamic acid( EC:1.5.1.12 )
xref_analog: EC:1.5.1.12
xref_analog: IMR:0200030
xref_analog: IMR:0200091
xref_analog: IMR:0200248
xref_analog: IMR:0200340
xref_analog: IMR:0200357
xref_analog: IMR:0200521
xref_analog: KEGG:map00330
xref_analog: KEGG:R05051
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0003002
name: ATP + L-Cysteine + tRNA(Cys) => AMP + L-Cysteinyl-tRNA(Cys) + Pyrophosphate( EC:6.1.1.16 )
xref_analog: EC:6.1.1.16
xref_analog: IMR:0001351
xref_analog: IMR:0200014
xref_analog: IMR:0200044
xref_analog: IMR:0200083
xref_analog: IMR:0200280
xref_analog: IMR:0200467
xref_analog: KEGG:map00970
xref_analog: KEGG:R03650
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001466 ! Methionine and Cysteine metabolism

[Term]
id: IEV:0003003
name: 3-Hydroxyisovaleryl-CoA = 3-Methylbut-2-enoyl-CoA + H2O( EC:4.2.1.17 )
comment: 3-Hydroxy-isopentyl-CoA = 3-Methylbut-2-enoyl-CoA + H2O( EC:4.2.1.17 )
xref_analog: EC:4.2.1.17
xref_analog: IMR:0200298
xref_analog: IMR:0200357
xref_analog: KEGG:C05998
xref_analog: KEGG:map00280
xref_analog: KEGG:R04137
is_a: IEV:0002759 ! (3S)-3-hydroxyacyl-CoA = trans-2,3-Dehydroacyl-CoA + H2O( EC:4.2.1.17 )
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0003004
name: 2-Oxo-glutaric acid + L-Aspartic acid = L-Glutamic acid + Oxaloacetic acid( EC:2.6.1.1 )
xref_analog: EC:2.6.1.1
xref_analog: IMR:0100119
xref_analog: IMR:0200339
xref_analog: IMR:0200459
xref_analog: IMR:0200480
xref_analog: KEGG:map00250
xref_analog: KEGG:map00710
xref_analog: KEGG:R00355
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001410 ! Alanine and aspartate metabolism

[Term]
id: IEV:0003005
name: 3',5'-Cyclic AMP + H2O => AMP( EC:3.1.4.17 )
xref_analog: EC:3.1.4.17
xref_analog: IMR:0100024
xref_analog: IMR:0200083
xref_analog: IMR:0200357
xref_analog: KEGG:map00230
xref_analog: KEGG:R00191
is_a: IEV:0002752 ! nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate( EC:3.1.4.17 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003006
name: L-Proline + 2-Oxo-glutaric acid + O2 => trans-4-Hydroxy-L-proline + Succinic acid + CO2( EC:1.14.11.2 )
xref_analog: EC:1.14.11.2
xref_analog: IMR:0200119
xref_analog: IMR:0200183
xref_analog: IMR:0200217
xref_analog: IMR:0200299
xref_analog: IMR:0200324
xref_analog: IMR:0200480
xref_analog: KEGG:map00330
xref_analog: KEGG:R01252
is_a: IEV:0002726 ! procollagen L-proline + 2-Oxo-glutaric acid + O2 = procollagen trans-4-hydroxy-L-proline + Succinic acid + CO2( EC:1.14.11.2 )
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0003007
name: GTP + L-Fucose 1-phosphate = GDP-L-fucose + Pyrophosphate( EC:2.7.7.30 )
xref_analog: EC:2.7.7.30
xref_analog: IMR:0001354
xref_analog: IMR:0200101
xref_analog: IMR:0200150
xref_analog: IMR:0200280
xref_analog: KEGG:map00051
xref_analog: KEGG:map00520
xref_analog: KEGG:R01951
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001417 ! Fructose and mannose metabolism

[Term]
id: IEV:0003008
name: ATP + AMP = 2 ADP( EC:2.7.4.3 )
xref_analog: EC:2.7.4.3
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200083
xref_analog: KEGG:map00230
xref_analog: KEGG:R00127
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003009
name: NADPH + Prostaglandin D2 + H+ => NADP+ + 11-epi-Prostaglandin F2alpha( EC:1.1.1.188 )
comment: NADPH + Prostaglandin D2 => NADP+ + 11-epi-Prostaglandin F2alpha( EC:1.1.1.188 )
xref_analog: EC:1.1.1.188
xref_analog: IMR:0200030
xref_analog: IMR:0200046
xref_analog: IMR:0200067
xref_analog: IMR:0200457
xref_analog: IMR:0200463
xref_analog: KEGG:map00590
xref_analog: KEGG:R02799
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001449 ! Arachidonic acid metabolism

[Term]
id: IEV:0003010
name: ATP + dCDP = ADP + dCTP( EC:2.7.4.6 )
xref_analog: EC:2.7.4.6
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200078
xref_analog: IMR:0200235
xref_analog: KEGG:map00240
xref_analog: KEGG:R02326
is_a: IEV:0002907 ! ATP + Nucleoside diphosphate = ADP + Nucleoside triphosphate( EC:2.7.4.6 )
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003011
name: Inosine + Orthophosphate = Hypoxanthine + D-Ribose 1-phosphate( EC:2.4.2.1 )
xref_analog: EC:2.4.2.1
xref_analog: IMR:0200102
xref_analog: IMR:0200173
xref_analog: IMR:0200194
xref_analog: KEGG:C00620
xref_analog: KEGG:map00230
xref_analog: KEGG:R01863
is_a: IEV:0002742 ! purine nucleoside + Orthophosphate = purine + D-ribose 1-phosphate( EC:2.4.2.1 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003012
name: D-Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate = D-Erythrose 4-phosphate + beta-D-Fructose 6-phosphate( EC:2.2.1.2 )
comment: D-Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate = D-Erythrose 4-phosphate + D-Fructose 6-phosphate( EC:2.2.1.2 )
xref_analog: EC:2.2.1.2
xref_analog: IMR:0200012
xref_analog: IMR:0200058
xref_analog: IMR:0200141
xref_analog: KEGG:C05345
xref_analog: KEGG:map00030
xref_analog: KEGG:R01827
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001414 ! Pentose phosphate pathway

[Term]
id: IEV:0003013
name: L-Tyrosine => Tyramine + CO2( EC:4.1.1.28 )
xref_analog: EC:4.1.1.28
xref_analog: IMR:0100124
xref_analog: IMR:0200240
xref_analog: IMR:0200324
xref_analog: KEGG:map00350
xref_analog: KEGG:map00950
xref_analog: KEGG:R00736
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0003014
name: Cytidine + H2O => Uridine + NH3( EC:3.5.4.5 )
xref_analog: EC:3.5.4.5
xref_analog: IMR:0200021
xref_analog: IMR:0200075
xref_analog: IMR:0200161
xref_analog: IMR:0200357
xref_analog: KEGG:map00240
xref_analog: KEGG:R01878
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003015
name: ATP + H2O => ADP + Orthophosphate( EC:3.6.1.5 )
xref_analog: EC:3.6.1.5
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: KEGG:map00230
xref_analog: KEGG:R00086
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003016
name: Nicotinamide D-ribonucleotide + Pyrophosphate = Nicotinamide + 5-Phospho-alpha-D-ribose 1-diphosphate( EC:2.4.2.12 )
comment: Nicotinamide D-ribonucleotide + Pyrophosphate = Nicotinamide + D-5-Phospho-ribosyl 1-diphosphate( EC:2.4.2.12 )
xref_analog: EC:2.4.2.12
xref_analog: IMR:0200025
xref_analog: IMR:0200166
xref_analog: IMR:0200179
xref_analog: IMR:0200280
xref_analog: KEGG:map00760
xref_analog: KEGG:R01271
is_a: IEV:0002560 ! Glycosylation
relationship: part_of IEV:0001510 ! Nicotinate and nicotinamide metabolism

[Term]
id: IEV:0003017
name: ATP + 1-Phosphatidyl-1D-myo-inositol 5-phosphate => ADP + 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate( EC:2.7.1.149 )
xref_analog: EC:2.7.1.149
xref_analog: IMR:0001350
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200149
xref_analog: KEGG:map00562
xref_analog: KEGG:map04070
xref_analog: KEGG:R05803
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0003018
name: Deoxy-adenosine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Adenine( EC:2.4.2.1 )
comment: Deoxy-adenosine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Adenine( EC:2.4.2.4 )
xref_analog: EC:2.4.2.1
xref_analog: IMR:0200048
xref_analog: IMR:0200102
xref_analog: IMR:0200226
xref_analog: IMR:0200350
xref_analog: KEGG:map00230
xref_analog: KEGG:R02557
is_a: IEV:0002560 ! Glycosylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003019
name: (S)-3-Hydroxy-3-methyl-glutaryl-CoA = Acetyl-CoA + Acetoacetic acid( EC:4.1.3.4 )
xref_analog: EC:4.1.3.4
xref_analog: IMR:0200033
xref_analog: IMR:0200064
xref_analog: IMR:0200414
xref_analog: KEGG:map00072
xref_analog: KEGG:map00280
xref_analog: KEGG:map00650
xref_analog: KEGG:R01360
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001427 ! Butanoate metabolism
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0003020
name: S-Adenosyl-L-methionine + L-Noradrenaline => S-Adenosyl-L-homocysteine + L-Adrenaline( EC:2.1.1.28 )
xref_analog: EC:2.1.1.28
xref_analog: IMR:0100114
xref_analog: IMR:0100115
xref_analog: IMR:0200054
xref_analog: IMR:0200151
xref_analog: KEGG:map00350
xref_analog: KEGG:R02533
is_a: IEV:0000433 ! Transmethylation
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0003021
name: NAD+ + CoA + (S)-Methyl-malonate semialdehyde => NADH + Propanoyl-CoA + CO2 + H+( EC:1.2.1.27 )
comment: NAD+ + CoA + (S)-Methyl-malonate semialdehyde => NADH + Propanoyl-CoA + CO2( EC:1.2.1.27 )
xref_analog: EC:1.2.1.27
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200297
xref_analog: IMR:0200324
xref_analog: IMR:0200354
xref_analog: IMR:0200484
xref_analog: IMR:0200521
xref_analog: KEGG:map00280
xref_analog: KEGG:map00640
xref_analog: KEGG:R00935
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001426 ! Propanoate metabolism

[Term]
id: IEV:0003022
name: NADH + L-1-Pyrroline-3-hydroxy-5-carboxylic acid + H+ = NAD+ + trans-4-Hydroxy-L-proline( EC:1.5.1.2 )
alt_id: IEV:0003030
comment: IEV:0003022: NADH + L-1-Pyrroline-3-hydroxy-5-carboxylic acid = NAD+ + trans-4-Hydroxy-L-proline( EC:1.5.1.2 )\n--------------------\nIEV:0003030: NAD+ + trans-4-Hydroxy-L-proline => NADH + L-1-Pyrroline-3-hydroxy-5-carboxylic acid( EC:1.5.1.12 )
xref_analog: EC:1.5.1.2
xref_analog: IMR:0200030
xref_analog: IMR:0200225
xref_analog: IMR:0200248
xref_analog: IMR:0200299
xref_analog: IMR:0200521
xref_analog: KEGG:map00330
xref_analog: KEGG:R03291
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0003023
name: N6-Acetyl-L-lysine + 2-Oxo-glutaric acid = 6-Acetamido-2-oxo-hexanoic acid + L-Glutamic acid( EC:2.6.1.65 )
comment: N6-Acetyl-L-lysine + 2-Oxo-glutaric acid = 6-Acetamido-2-oxo-hexanoic acid + L-Glutamic acid( EC:2.6.1.39 )
xref_analog: EC:2.6.1.65
xref_analog: IMR:0100119
xref_analog: IMR:0200143
xref_analog: IMR:0200214
xref_analog: IMR:0200480
xref_analog: KEGG:map00310
xref_analog: KEGG:R04029
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001457 ! Lysine degradation

[Term]
id: IEV:0003024
name: Deoxy-guanosine + Orthophosphate = 2-Deoxy-D-ribose 1-phosphate + Guanine( EC:2.4.2.4 )
xref_analog: EC:2.4.2.4
xref_analog: IMR:0200048
xref_analog: IMR:0200102
xref_analog: IMR:0200319
xref_analog: IMR:0200495
xref_analog: KEGG:map00230
xref_analog: KEGG:R01969
is_a: IEV:0002560 ! Glycosylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003025
name: Xanthosine + Orthophosphate = Xanthine + D-Ribose 1-phosphate( EC:2.4.2.1 )
xref_analog: EC:2.4.2.1
xref_analog: IMR:0200102
xref_analog: IMR:0200426
xref_analog: IMR:0200439
xref_analog: KEGG:C00620
xref_analog: KEGG:map00230
xref_analog: KEGG:R02297
is_a: IEV:0002742 ! purine nucleoside + Orthophosphate = purine + D-ribose 1-phosphate( EC:2.4.2.1 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003026
name: ATP + Deoxy-uridine => ADP + dUMP( EC:2.7.1.21 )
xref_analog: EC:2.7.1.21
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200008
xref_analog: IMR:0200103
xref_analog: KEGG:map00240
xref_analog: KEGG:R02099
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003027
name: CoA + GTP + Succinic acid = Succinyl-CoA + GDP + Orthophosphate( EC:6.2.1.4 )
xref_analog: EC:6.2.1.4
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: IMR:0200037
xref_analog: IMR:0200102
xref_analog: IMR:0200119
xref_analog: IMR:0200354
xref_analog: KEGG:map00020
xref_analog: KEGG:map00640
xref_analog: KEGG:R00432
is_a: IEV:0000394 ! CoA ligation
relationship: part_of IEV:0001415 ! Citrate cycle (TCA cycle)

[Term]
id: IEV:0003028
name: ATP + D-Glucosamine => ADP + D-Glucosamine 6-phosphate( EC:2.7.1.1 )
xref_analog: EC:2.7.1.1
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200228
xref_analog: IMR:0200485
xref_analog: KEGG:map00520
xref_analog: KEGG:R01961
is_a: IEV:0002744 ! ATP + D-hexose = ADP + D-hexose 6-phosphate( EC:2.7.1.1 )
relationship: part_of IEV:0001421 ! Aminosugars metabolism

[Term]
id: IEV:0003029
name: ATP + Cytidine => ADP + CMP( EC:2.7.1.48 )
xref_analog: EC:2.7.1.48
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200161
xref_analog: IMR:0200494
xref_analog: KEGG:map00240
xref_analog: KEGG:R00513
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003031
name: GMP + H2O => Guanosine + Orthophosphate( EC:3.1.3.5 )
xref_analog: EC:3.1.3.5
xref_analog: IMR:0200102
xref_analog: IMR:0200292
xref_analog: IMR:0200357
xref_analog: IMR:0200445
xref_analog: KEGG:map00230
xref_analog: KEGG:R01227
is_a: IEV:0002751 ! 5'-ribonucleotide + H2O = ribonucleoside + phosphate( EC:3.1.3.5 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003032
name: 2 NADPH + (S)-3-Hydroxy-3-methyl-glutaryl-CoA + 2 H+ => 2 NADP+ + CoA + (R)-Mevalonic acid( EC:1.1.1.34 )
comment: 2 NADPH + (S)-3-Hydroxy-3-methyl-glutaryl-CoA => 2 NADP+ + CoA + (R)-Mevalonic acid( EC:1.1.1.34 )
xref_analog: EC:1.1.1.34
xref_analog: IMR:0200030
xref_analog: IMR:0200033
xref_analog: IMR:0200067
xref_analog: IMR:0200118
xref_analog: IMR:0200354
xref_analog: IMR:0200463
xref_analog: KEGG:map00900
xref_analog: KEGG:R02082
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001443 ! Steroid biosynthesis

[Term]
id: IEV:0003033
name: UDP-D-glucose = UDP-D-galactose( EC:5.1.3.2 )
xref_analog: EC:5.1.3.2
xref_analog: IMR:0200227
xref_analog: IMR:0200283
xref_analog: KEGG:map00052
xref_analog: KEGG:map00520
xref_analog: KEGG:R00291
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001418 ! Galactose metabolism

[Term]
id: IEV:0003034
name: GDP + Reduced thioredoxin => dGDP + H2O + Oxidized thioredoxin( EC:1.17.4.1 )
xref_analog: EC:1.17.4.1
xref_analog: IMR:0001357
xref_analog: IMR:0200108
xref_analog: IMR:0200133
xref_analog: IMR:0200357
xref_analog: IMR:0200365
xref_analog: KEGG:map00230
xref_analog: KEGG:R02019
is_a: IEV:0002728 ! 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin( EC:1.17.4.1 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003035
name: ATP + L-Asparagine + tRNA(Asn) => AMP + L-Asparaginyl-tRNA(Asn) + Pyrophosphate( EC:6.1.1.22 )
xref_analog: EC:6.1.1.22
xref_analog: IMR:0001351
xref_analog: IMR:0200083
xref_analog: IMR:0200105
xref_analog: IMR:0200113
xref_analog: IMR:0200280
xref_analog: IMR:0200328
xref_analog: KEGG:map00970
xref_analog: KEGG:R03648
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001410 ! Alanine and aspartate metabolism

[Term]
id: IEV:0003036
name: D-Glyceraldehyde 3-phosphate = Dihydroxy-acetone phosphate( EC:5.3.1.1 )
xref_analog: EC:5.3.1.1
xref_analog: IMR:0200058
xref_analog: IMR:0200100
xref_analog: KEGG:map00010
xref_analog: KEGG:map00051
xref_analog: KEGG:map00562
xref_analog: KEGG:map00710
xref_analog: KEGG:R01015
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001417 ! Fructose and mannose metabolism

[Term]
id: IEV:0003037
name: Lactose + H2O => alpha-D-Glucose + D-Galactose( EC:3.2.1.23 )
comment: Lactose + H2O => D-Glucose + D-Galactose( EC:3.2.1.23 )
xref_analog: EC:3.2.1.23
xref_analog: IMR:0200123
xref_analog: IMR:0200277
xref_analog: IMR:0200357
xref_analog: KEGG:C00267
xref_analog: KEGG:map00052
xref_analog: KEGG:R01678
is_a: IEV:0002753 ! Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides( EC:3.2.1.23 )
relationship: part_of IEV:0001418 ! Galactose metabolism

[Term]
id: IEV:0003038
name: ATP + L-Glutamine + tRNA(Gln) => AMP + Glutaminyl-tRNA + Pyrophosphate( EC:6.1.1.18 )
xref_analog: EC:6.1.1.18
xref_analog: IMR:0001351
xref_analog: IMR:0200083
xref_analog: IMR:0200117
xref_analog: IMR:0200280
xref_analog: IMR:0200448
xref_analog: IMR:0200506
xref_analog: KEGG:map00970
xref_analog: KEGG:R03652
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001411 ! Glutamate metabolism

[Term]
id: IEV:0003039
name: ATP + 3-Methylbut-2-enoyl-CoA + HCO3- => ADP + 3-Methyl-glutaconyl-CoA + Orthophosphate( EC:6.4.1.4 )
comment: ATP + 3-Methylbut-2-enoyl-CoA + CO2 + H2O => ADP + 3-Methyl-glutaconyl-CoA + Orthophosphate( EC:6.4.1.4 )
xref_analog: EC:6.4.1.4
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200069
xref_analog: IMR:0200102
xref_analog: IMR:0200298
xref_analog: KEGG:C00288
xref_analog: KEGG:map00280
xref_analog: KEGG:R04138
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0003040
name: ATP + 5'-Phospho-ribosyl-N-formyl-glycinamidine => ADP + 5'-Phospho-ribosyl-5-amino-imidazole + Orthophosphate( EC:6.3.3.1 )
xref_analog: EC:6.3.3.1
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200102
xref_analog: IMR:0200398
xref_analog: IMR:0200513
xref_analog: KEGG:map00230
xref_analog: KEGG:R04208
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003041
name: 2-Oxo-glutaric acid + L-Leucine = L-Glutamic acid + 4-Methyl-2-oxo-pentanoic acid( EC:2.6.1.42 )
xref_analog: EC:2.6.1.42
xref_analog: IMR:0100119
xref_analog: IMR:0200370
xref_analog: IMR:0200480
xref_analog: IMR:0200492
xref_analog: KEGG:map00280
xref_analog: KEGG:map00290
xref_analog: KEGG:map00966
xref_analog: KEGG:R01090
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0003042
name: UTP + H2O => UMP + Pyrophosphate( EC:3.6.1.19 )
xref_analog: EC:3.6.1.19
xref_analog: IMR:0200199
xref_analog: IMR:0200280
xref_analog: IMR:0200357
xref_analog: IMR:0200409
xref_analog: KEGG:map00240
xref_analog: KEGG:R00662
is_a: IEV:0002755 ! Nucleoside triphosphate + H2O = Nucleotide + diphosphate( EC:3.6.1.19 )
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003043
name: ATP + (R)-5-Diphosphomevalonate => ADP + Isopentenyl diphosphate + Orthophosphate + CO2( EC:4.1.1.33 )
comment: ATP + (R)-Mevalonic acid 5-diphosphate => ADP + Isopentenyl diphosphate + Orthophosphate + CO2( EC:4.1.1.33 )
xref_analog: EC:4.1.1.33
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200102
xref_analog: IMR:0200287
xref_analog: IMR:0200324
xref_analog: IMR:0200431
xref_analog: KEGG:map00900
xref_analog: KEGG:R01121
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001443 ! Steroid biosynthesis

[Term]
id: IEV:0003044
name: S-Adenosyl-L-methionine + Histamine => S-Adenosyl-L-homocysteine + N-Methyl-histamine( EC:2.1.1.8 )
xref_analog: EC:2.1.1.8
xref_analog: IMR:0100125
xref_analog: IMR:0200054
xref_analog: IMR:0200151
xref_analog: IMR:0200401
xref_analog: KEGG:map00340
xref_analog: KEGG:R02155
is_a: IEV:0000433 ! Transmethylation
relationship: part_of IEV:0001459 ! Histidine metabolism

[Term]
id: IEV:0003045
name: 2-Oxo-glutaric acid + L-Phenylalanine = L-Glutamic acid + Phenyl-pyruvic acid( EC:2.6.1.5 )
xref_analog: EC:2.6.1.5
xref_analog: IMR:0100119
xref_analog: IMR:0200274
xref_analog: IMR:0200380
xref_analog: IMR:0200480
xref_analog: KEGG:map00360
xref_analog: KEGG:map00400
xref_analog: KEGG:R00694
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001461 ! Phenylalanine metabolism

[Term]
id: IEV:0003046
name: S-Adenosyl-L-methionine + 5-Hydroxy-indole-acetic acid => S-Adenosyl-L-homocysteine + 5-Methoxy-indole-acetic acid( EC:2.1.1.4 )
xref_analog: EC:2.1.1.4
xref_analog: IMR:0200052
xref_analog: IMR:0200054
xref_analog: IMR:0200151
xref_analog: IMR:0200201
xref_analog: KEGG:map00380
xref_analog: KEGG:R04905
is_a: IEV:0000433 ! Transmethylation
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0003047
name: Phenyl-ethylamine + O2 + H2O => Phenyl-acetaldehyde + H2O2 + NH3( EC:1.4.3.21 )
comment: Phenyl-ethylamine + O2 + H2O => Phenyl-acetaldehyde + H2O2 + NH3( EC:1.4.3.6 )
xref_analog: EC:1.4.3.21
xref_analog: IMR:0200075
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200418
xref_analog: IMR:0200487
xref_analog: IMR:0200516
xref_analog: KEGG:map00360
xref_analog: KEGG:R02613
is_a: IEV:0002735 ! Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.21 )
relationship: part_of IEV:0001461 ! Phenylalanine metabolism

[Term]
id: IEV:0003048
name: CoA + ATP + Butanoic acid => Butanoyl-CoA + AMP + Pyrophosphate( EC:6.2.1.2 )
xref_analog: EC:6.2.1.2
xref_analog: IMR:0001351
xref_analog: IMR:0200083
xref_analog: IMR:0200195
xref_analog: IMR:0200280
xref_analog: IMR:0200308
xref_analog: IMR:0200354
xref_analog: KEGG:map00650
xref_analog: KEGG:R01176
is_a: IEV:0000394 ! CoA ligation
relationship: part_of IEV:0001427 ! Butanoate metabolism

[Term]
id: IEV:0003049
name: Leukotriene C4 + Amino acid => Leukotriene D4 + 5-L-Glutamyl amino acid( EC:2.3.2.2 )
comment: Lucotriene C4 + H2O => Leucotriene D4 + L-Glutamic acid( EC:2.3.2.2 )
xref_analog: EC:2.3.2.2
xref_analog: IMR:0001695
xref_analog: IMR:0200432
xref_analog: IMR:0200458
xref_analog: KEGG:C03363
xref_analog: KEGG:map00590
xref_analog: KEGG:R03867
is_a: IEV:0002741 ! (5-L-glutamyl)-peptide + Amino acid = peptide + 5-L-glutamyl amino acid( EC:2.3.2.2 )
relationship: part_of IEV:0001449 ! Arachidonic acid metabolism

[Term]
id: IEV:0003050
name: ATP + Creatine = ADP + N-Phospho-creatine( EC:2.7.3.2 )
xref_analog: EC:2.7.3.2
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200144
xref_analog: IMR:0200204
xref_analog: KEGG:map00330
xref_analog: KEGG:R01881
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0003051
name: NAD+ + 4-Trimethyl-ammonio-butanal + H2O = NADH + 4-Trimethyl-ammonio-butanoic acid + H+( EC:1.2.1.47 )
comment: NAD+ + 4-Trimethyl-ammonio-butanal + H2O = NADH + 4-Trimethyl-ammonio-butanoic acid( EC:1.2.1.47 )
xref_analog: EC:1.2.1.47
xref_analog: IMR:0200030
xref_analog: IMR:0200070
xref_analog: IMR:0200168
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: IMR:0200521
xref_analog: KEGG:map00310
xref_analog: KEGG:R03283
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001457 ! Lysine degradation

[Term]
id: IEV:0003052
name: NAD+ + 4-Hydroxy-phenyl-acetaldehyde + H2O = NADH + 4-Hydroxy-phenyl-acetic acid + H+( EC:1.2.1.5 )
comment: NAD+ + 4-Hydroxy-phenyl-acetaldehyde + H2O = NADH + 4-Hydroxy-phenyl-acetic acid( EC:1.2.1.5 )
xref_analog: EC:1.2.1.5
xref_analog: IMR:0200030
xref_analog: IMR:0200040
xref_analog: IMR:0200216
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: IMR:0200521
xref_analog: KEGG:map00350
xref_analog: KEGG:R02695
is_a: IEV:0002730 ! Aldehyde + NADP+ + H2O = Carboxylate + NADPH + H+( EC:1.2.1.5 )
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0003053
name: CDP + Reduced thioredoxin => dCDP + H2O + Oxidized thioredoxin( EC:1.17.4.1 )
xref_analog: EC:1.17.4.1
xref_analog: IMR:0200078
xref_analog: IMR:0200108
xref_analog: IMR:0200133
xref_analog: IMR:0200357
xref_analog: IMR:0200468
xref_analog: KEGG:map00240
xref_analog: KEGG:R02024
is_a: IEV:0002728 ! 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin( EC:1.17.4.1 )
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003054
name: Dihydro-lipoylprotein + 5,10-Methylene-tetrahydro-folic acid + NH3 => S-Aminomethyl-dihydro-lipoylprotein + Tetrahydrofolate( EC:2.1.2.10 )
alt_id: IEV:0002738
comment: Dihydro-lipoylprotein + 5,10-Methylene-tetrahydro-folic acid + NH3 => S-Aminomethyl-dihydro-lipoylprotein + L-Tetrahydro-folic acid( EC:2.1.2.10 )
exact_synonym: "S-aminomethyldihydrolipoyllysine + tetrahydrofolate = dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3( EC:2.1.2.10 )" []
xref_analog: EC:2.1.2.10
xref_analog: IMR:0200075
xref_analog: IMR:0200330
xref_analog: IMR:0200367
xref_analog: IMR:0200377
xref_analog: IMR:0200517
xref_analog: KEGG:map00260
xref_analog: KEGG:map00670
xref_analog: KEGG:R04125
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0003055
name: CDP + H2O => CMP + Orthophosphate( EC:3.6.1.5 )
xref_analog: EC:3.6.1.5
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: IMR:0200468
xref_analog: IMR:0200494
xref_analog: KEGG:map00240
xref_analog: KEGG:R00514
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003056
name: NAD+ + 5,10-Methylene-tetrahydro-folic acid = NADH + 5,10-Methenyl-tetrahydro-folic acid( EC:1.5.1.15 )
xref_analog: EC:1.5.1.15
xref_analog: IMR:0200159
xref_analog: IMR:0200248
xref_analog: IMR:0200517
xref_analog: IMR:0200521
xref_analog: KEGG:map00670
xref_analog: KEGG:R01218
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0003057
name: 3-Carboxy-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine = TPP + [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine( EC:1.2.4.2 )
comment: 3-Carboxy-1-hydroxypropyl-ThPP + Lipoamide = TPP + S-Succinyl-dihydro-lipoamide( EC:1.2.4.2 )
xref_analog: EC:1.2.4.2
xref_analog: IMR:0002042
xref_analog: IMR:0200378
xref_analog: KEGG:C15972
xref_analog: KEGG:C16254
xref_analog: KEGG:map00020
xref_analog: KEGG:R03316
relationship: part_of IEV:0002763 ! 2-Oxo-glutaric acid + Enzyme N6-(lipoyl)lysine = [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2( EC:1.2.4.2 )

[Term]
id: IEV:0003058
name: Leukotriene A4 + Glutathione => Leukotriene C4( EC:4.4.1.20 )
xref_analog: EC:4.4.1.20
xref_analog: IMR:0200318
xref_analog: IMR:0200458
xref_analog: IMR:0200461
xref_analog: KEGG:map00590
xref_analog: KEGG:R03059
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001449 ! Arachidonic acid metabolism

[Term]
id: IEV:0003059
name: Uridine + Orthophosphate = Uracil + D-Ribose 1-phosphate( EC:2.4.2.3 )
xref_analog: EC:2.4.2.3
xref_analog: IMR:0200021
xref_analog: IMR:0200102
xref_analog: IMR:0200234
xref_analog: KEGG:C00620
xref_analog: KEGG:map00240
xref_analog: KEGG:R01876
is_a: IEV:0002560 ! Glycosylation
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003060
name: NADP+ + D-Sorbitol = NADPH + alpha-D-Glucose + H+( EC:1.1.1.21 )
comment: NADP+ + D-Sorbitol = NADPH + alpha-D-Glucose( EC:1.1.1.21 )
xref_analog: EC:1.1.1.21
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200462
xref_analog: IMR:0200463
xref_analog: KEGG:C00267
xref_analog: KEGG:map00051
xref_analog: KEGG:R01787
is_a: IEV:0002724 ! Alditol + NADP+ = Aldose + NADPH + H+( EC:1.1.1.21 )
relationship: part_of IEV:0001417 ! Fructose and mannose metabolism

[Term]
id: IEV:0003061
name: L-Tryptophan => Tryptamine + CO2( EC:4.1.1.28 )
xref_analog: EC:4.1.1.28
xref_analog: IMR:0200128
xref_analog: IMR:0200307
xref_analog: IMR:0200324
xref_analog: KEGG:map00380
xref_analog: KEGG:map00901
xref_analog: KEGG:R00685
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0003062
name: Guanosine + Orthophosphate = Guanine + D-Ribose 1-phosphate( EC:2.4.2.1 )
xref_analog: EC:2.4.2.1
xref_analog: IMR:0200102
xref_analog: IMR:0200319
xref_analog: IMR:0200445
xref_analog: KEGG:C00620
xref_analog: KEGG:map00230
xref_analog: KEGG:R02147
is_a: IEV:0002742 ! purine nucleoside + Orthophosphate = purine + D-ribose 1-phosphate( EC:2.4.2.1 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003063
name: NADP+ + 2 Glutathione = NADPH + Glutathione disulfide + H+( EC:1.8.1.7 )
comment: NADP+ + 2 Glutathione = NADPH + Glutathione disulfide( EC:1.8.1.7 )
xref_analog: EC:1.8.1.7
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200318
xref_analog: IMR:0200364
xref_analog: IMR:0200463
xref_analog: KEGG:map00480
xref_analog: KEGG:R00115
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001411 ! Glutamate metabolism

[Term]
id: IEV:0003064
name: Tyramine + O2 + NADH + H+ => Dopamine + NAD+ + H2O( EC:1.14.18.1 )
comment: Tyramine + O2 => Dopamine + H2O( EC:1.14.18.1 )
xref_analog: EC:1.14.18.1
xref_analog: IMR:0100113
xref_analog: IMR:0100124
xref_analog: IMR:0200030
xref_analog: IMR:0200217
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: IMR:0200521
xref_analog: KEGG:map00950
xref_analog: KEGG:R02383
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0003065
name: ATP + (R)-Mevalonic acid 5-phosphate => ADP + (R)-5-Diphosphomevalonate( EC:2.7.4.2 )
comment: ATP + (R)-Mevalonic acid 5-phosphate => ADP + (R)-Mevalonic acid 5-diphosphate( EC:2.7.4.2 )
xref_analog: EC:2.7.4.2
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200139
xref_analog: IMR:0200431
xref_analog: KEGG:map00900
xref_analog: KEGG:R03245
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001443 ! Steroid biosynthesis

[Term]
id: IEV:0003066
name: NADP+ + 6-Phospho-D-gluconic acid => NADPH + D-Ribulose 5-phosphate + CO2 + H+( EC:1.1.1.44 )
comment: NADP+ + 6-Phospho-D-gluconic acid => NADPH + D-Ribulose 5-phosphate + CO2( EC:1.1.1.44 )
xref_analog: EC:1.1.1.44
xref_analog: IMR:0200030
xref_analog: IMR:0200059
xref_analog: IMR:0200061
xref_analog: IMR:0200067
xref_analog: IMR:0200324
xref_analog: IMR:0200463
xref_analog: KEGG:map00030
xref_analog: KEGG:map00480
xref_analog: KEGG:R01528
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001414 ! Pentose phosphate pathway

[Term]
id: IEV:0003067
name: Succinic acid + Ubiquinone = Fumaric acid + Ubiquinol( EC:1.3.5.1 )
xref_analog: EC:1.3.5.1
xref_analog: IMR:0200119
xref_analog: IMR:0200186
xref_analog: IMR:0200466
xref_analog: IMR:0200483
xref_analog: KEGG:map00020
xref_analog: KEGG:R02164
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001415 ! Citrate cycle (TCA cycle)

[Term]
id: IEV:0003068
name: GDP-D-mannose => GDP-4-dehydro-6-deoxy-D-mannose + H2O( EC:4.2.1.47 )
xref_analog: EC:4.2.1.47
xref_analog: IMR:0200357
xref_analog: IMR:0200451
xref_analog: IMR:0200472
xref_analog: KEGG:map00051
xref_analog: KEGG:map00520
xref_analog: KEGG:R00888
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001417 ! Fructose and mannose metabolism

[Term]
id: IEV:0003069
name: Arachidonic acid + O2 => 12(S)-HPETE( EC:1.13.11.31 )
comment: Arachidonic acid + O2 => 12-HPETE( EC:1.13.11.31 )
xref_analog: EC:1.13.11.31
xref_analog: IMR:0200027
xref_analog: IMR:0200212
xref_analog: IMR:0200217
xref_analog: KEGG:map00590
xref_analog: KEGG:R01596
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001449 ! Arachidonic acid metabolism

[Term]
id: IEV:0003070
name: 3',5'-Cyclic GMP + H2O => GMP( EC:3.1.4.17 )
xref_analog: EC:3.1.4.17
xref_analog: IMR:0100025
xref_analog: IMR:0200292
xref_analog: IMR:0200357
xref_analog: KEGG:map00230
xref_analog: KEGG:R01234
is_a: IEV:0002752 ! nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate( EC:3.1.4.17 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003071
name: Amino-acetone + O2 + H2O => Methyl-glyoxal + H2O2 + NH3( EC:1.4.3.21 )
comment: Amino-acetone + O2 + H2O => Methyl-glyoxal + H2O2 + NH3( EC:1.4.3.6 )
xref_analog: EC:1.4.3.21
xref_analog: IMR:0200075
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200360
xref_analog: IMR:0200471
xref_analog: IMR:0200487
xref_analog: KEGG:map00260
xref_analog: KEGG:R02529
is_a: IEV:0002735 ! Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.21 )
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism

[Term]
id: IEV:0003072
name: 4 Porphobilinogen + H2O => Hydroxy-methylbilane + 4 NH3( EC:2.5.1.61 )
comment: multi-step reaction
xref_analog: EC:2.5.1.61
xref_analog: IMR:0200002
xref_analog: IMR:0200075
xref_analog: IMR:0200357
xref_analog: IMR:0200436
xref_analog: KEGG:map00860
xref_analog: KEGG:R00084
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001516 ! Porphyrin and chlorophyll metabolism

[Term]
id: IEV:0003073
name: NAD+ + 3-Methoxy-4-hydroxy-phenyl-acetaldehyde + H2O = NADH + Homovanillic acid + H+( EC:1.2.1.5 )
comment: NAD+ + 3-Methoxy-4-hydroxy-phenyl-acetaldehyde + H2O = NADH + Homovanillic acid( EC:1.2.1.5 )
xref_analog: EC:1.2.1.5
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200269
xref_analog: IMR:0200357
xref_analog: IMR:0200383
xref_analog: IMR:0200521
xref_analog: KEGG:map00350
xref_analog: KEGG:R04888
is_a: IEV:0002730 ! Aldehyde + NADP+ + H2O = Carboxylate + NADPH + H+( EC:1.2.1.5 )
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0003074
name: NADH + 1,3-Bisphospho-D-glyceric acid + H+ = NAD+ + D-Glyceraldehyde 3-phosphate + Orthophosphate( EC:1.2.1.12 )
comment: NADH + 1,3-Bisphospho-D-glyceric acid = NAD+ + D-Glyceraldehyde 3-phosphate + Orthophosphate( EC:1.2.1.12 )
xref_analog: EC:1.2.1.12
xref_analog: IMR:0200030
xref_analog: IMR:0200058
xref_analog: IMR:0200102
xref_analog: IMR:0200248
xref_analog: IMR:0200362
xref_analog: IMR:0200521
xref_analog: KEGG:map00010
xref_analog: KEGG:R01061
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001413 ! Glycolysis and Gluconeogenesis

[Term]
id: IEV:0003075
name: L-Glutamine + 5-Phospho-alpha-D-ribose 1-diphosphate + H2O => L-Glutamic acid + 5-Phospho-ribosyl-1-amine + Pyrophosphate( EC:2.4.2.14 )
comment: L-Glutamine + D-5-Phospho-ribosyl 1-diphosphate + H2O => L-Glutamic acid + 5-Phospho-ribosyl-1-amine + Pyrophosphate( EC:2.4.2.14 )
xref_analog: EC:2.4.2.14
xref_analog: IMR:0100119
xref_analog: IMR:0200179
xref_analog: IMR:0200280
xref_analog: IMR:0200357
xref_analog: IMR:0200420
xref_analog: IMR:0200448
xref_analog: KEGG:map00230
xref_analog: KEGG:map00250
xref_analog: KEGG:R01072
is_a: IEV:0002560 ! Glycosylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003076
name: L-Noradrenaline + H2O + O2 => 3,4-Dihydroxy-mandelaldehyde + NH3 + H2O2( EC:1.4.3.4 )
xref_analog: EC:1.4.3.4
xref_analog: IMR:0100115
xref_analog: IMR:0200075
xref_analog: IMR:0200217
xref_analog: IMR:0200289
xref_analog: IMR:0200357
xref_analog: IMR:0200487
xref_analog: KEGG:map00350
xref_analog: KEGG:R02532
is_a: IEV:0002734 ! Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.4 )
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0003077
name: Acetyl-CoA + D-Glucosamine 6-phosphate => CoA + N-Acetyl-D-glucosamine 6-phosphate( EC:2.3.1.4 )
xref_analog: EC:2.3.1.4
xref_analog: IMR:0200228
xref_analog: IMR:0200259
xref_analog: IMR:0200354
xref_analog: IMR:0200414
xref_analog: KEGG:map00520
xref_analog: KEGG:R02058
is_a: IEV:0002399 ! Transacetylation
relationship: part_of IEV:0001421 ! Aminosugars metabolism

[Term]
id: IEV:0003078
name: 3-Ureidoisobutyrate + H2O => 3-Aminoisobutyric acid + CO2 + NH3( EC:3.5.1.6 )
comment: 3-Ureido-2-methyl-propanoic acid + H2O => (S)-3-Amino-2-methyl-propanoic acid + CO2 + NH3( EC:3.5.1.6 )
xref_analog: EC:3.5.1.6
xref_analog: IMR:0200075
xref_analog: IMR:0200132
xref_analog: IMR:0200324
xref_analog: IMR:0200357
xref_analog: KEGG:C05145
xref_analog: KEGG:map00240
xref_analog: KEGG:R04666
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003079
name: Acyl-CoA + Cholesterol = CoA + Cholesterol ester( EC:2.3.1.26 )
xref_analog: EC:2.3.1.26
xref_analog: IMR:0200050
xref_analog: IMR:0200065
xref_analog: IMR:0200354
xref_analog: IMR:0200486
xref_analog: KEGG:map00100
xref_analog: KEGG:R01461
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001443 ! Steroid biosynthesis

[Term]
id: IEV:0003080
name: (S)-Dihydro-orotic acid + H2O = N-Carbamoyl-L-aspartic acid( EC:3.5.2.3 )
xref_analog: EC:3.5.2.3
xref_analog: IMR:0200077
xref_analog: IMR:0200357
xref_analog: IMR:0200393
xref_analog: KEGG:map00240
xref_analog: KEGG:R01993
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003081
name: GTP + H2O => 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydro-pteridine triphosphate + Formic acid( EC:3.5.4.16 )
comment: four-step reaction
xref_analog: EC:3.5.4.16
xref_analog: IMR:0001354
xref_analog: IMR:0200110
xref_analog: IMR:0200357
xref_analog: IMR:0200406
xref_analog: KEGG:R00424
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0003082
name: L-Dopa => Dopamine + CO2( EC:4.1.1.28 )
xref_analog: EC:4.1.1.28
xref_analog: IMR:0100113
xref_analog: IMR:0200290
xref_analog: IMR:0200324
xref_analog: KEGG:map00350
xref_analog: KEGG:map00950
xref_analog: KEGG:map00965
xref_analog: KEGG:R02080
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0003083
name: Acetyl-CoA + Serotonin => CoA + N-Acetyl-serotonin( EC:2.3.1.87 )
xref_analog: EC:2.3.1.87
xref_analog: IMR:0100123
xref_analog: IMR:0200180
xref_analog: IMR:0200354
xref_analog: IMR:0200414
xref_analog: KEGG:map00380
xref_analog: KEGG:R02911
is_a: IEV:0003315 ! Acetyl-CoA + 2-arylethylamine = CoA + N-acetyl-2-arylethylamine( EC:2.3.1.87 )
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0003084
name: NAD+ + H2O => Nicotinamide D-ribonucleotide + AMP( EC:3.6.1.9 )
xref_analog: EC:3.6.1.9
xref_analog: IMR:0200083
xref_analog: IMR:0200166
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: KEGG:map00760
xref_analog: KEGG:R00103
is_a: IEV:0002758 ! dinucleotide + H2O = 2 mononucleotide( EC:3.6.1.9 )
relationship: part_of IEV:0001510 ! Nicotinate and nicotinamide metabolism

[Term]
id: IEV:0003085
name: 2-Oxo-glutaric acid + L-Tyrosine = L-Glutamic acid + 4-Hydroxy-phenyl-pyruvic acid( EC:2.6.1.5 )
xref_analog: EC:2.6.1.5
xref_analog: IMR:0100119
xref_analog: IMR:0200240
xref_analog: IMR:0200341
xref_analog: IMR:0200480
xref_analog: KEGG:map00130
xref_analog: KEGG:map00350
xref_analog: KEGG:map00400
xref_analog: KEGG:map00401
xref_analog: KEGG:map00950
xref_analog: KEGG:R00734
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0003086
name: UTP + D-Glucose 1-phosphate = Pyrophosphate + UDP-D-glucose( EC:2.7.7.9 )
xref_analog: EC:2.7.7.9
xref_analog: IMR:0200190
xref_analog: IMR:0200199
xref_analog: IMR:0200280
xref_analog: IMR:0200283
xref_analog: KEGG:map00040
xref_analog: KEGG:map00052
xref_analog: KEGG:map00500
xref_analog: KEGG:map00520
xref_analog: KEGG:R00289
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001418 ! Galactose metabolism

[Term]
id: IEV:0003087
name: Glycine + Succinyl-CoA =>  CO2 + 5-Amino-4-oxo-pentanoic acid + CoA( EC:2.3.1.37 )
xref_analog: EC:2.3.1.37
xref_analog: IMR:0100118
xref_analog: IMR:0200037
xref_analog: IMR:0200264
xref_analog: IMR:0200324
xref_analog: IMR:0200354
xref_analog: KEGG:map00260
xref_analog: KEGG:R00830
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism

[Term]
id: IEV:0003088
name: CoA + 2-Methyl-3-acetoacetyl-CoA => Acetyl-CoA + Propanoyl-CoA( EC:2.3.1.16 )
xref_analog: EC:2.3.1.16
xref_analog: IMR:0200288
xref_analog: IMR:0200354
xref_analog: IMR:0200414
xref_analog: IMR:0200484
xref_analog: KEGG:map00280
xref_analog: KEGG:R00927
is_a: IEV:0002739 ! Acyl-CoA + Acetyl-CoA = CoA + 3-Oxoacyl-CoA( EC:2.3.1.16 )
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0003089
name: (R)-S-Lactoyl-glutathione + H2O => Glutathione + (R)-Lactic acid( EC:3.1.2.6 )
xref_analog: EC:3.1.2.6
xref_analog: IMR:0002043
xref_analog: IMR:0200313
xref_analog: IMR:0200318
xref_analog: IMR:0200357
xref_analog: KEGG:map00620
xref_analog: KEGG:R01736
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001424 ! Pyruvate metabolism

[Term]
id: IEV:0003090
name: L-Aspartic acid => beta-Alanine + CO2( EC:4.1.1.15 )
xref_analog: EC:4.1.1.15
xref_analog: IMR:0200324
xref_analog: IMR:0200438
xref_analog: IMR:0200459
xref_analog: KEGG:map00410
xref_analog: KEGG:map00770
xref_analog: KEGG:R00489
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001410 ! Alanine and aspartate metabolism

[Term]
id: IEV:0003091
name: Prostaglandin G2 + Reduced acceptor => Prostaglandin H2 + H2O + Acceptor( EC:1.14.99.1 )
xref_analog: EC:1.14.99.1
xref_analog: IMR:0200224
xref_analog: IMR:0200253
xref_analog: IMR:0200300
xref_analog: IMR:0200357
xref_analog: IMR:0200497
xref_analog: KEGG:map00590
xref_analog: KEGG:R00073
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0003852 ! Arachidonic acid + Reduced acceptor + 2 O2 = Prostaglandin H2 + Acceptor + H2O( EC:1.14.99.1 )

[Term]
id: IEV:0003092
name: Nicotinate D-ribonucleotide + H2O => Nicotinate D-ribonucleoside + Orthophosphate( EC:3.1.3.5 )
xref_analog: EC:3.1.3.5
xref_analog: IMR:0200102
xref_analog: IMR:0200104
xref_analog: IMR:0200262
xref_analog: IMR:0200357
xref_analog: KEGG:map00760
xref_analog: KEGG:R03346
is_a: IEV:0002751 ! 5'-ribonucleotide + H2O = ribonucleoside + phosphate( EC:3.1.3.5 )
relationship: part_of IEV:0001510 ! Nicotinate and nicotinamide metabolism

[Term]
id: IEV:0003093
name: ATP + gamma-L-Glutamyl-L-cysteine + Glycine => ADP + Glutathione + Orthophosphate( EC:6.3.2.3 )
comment: ATP + 5-L-Glutamyl-cysteine + Glycine => ADP + Glutathione + Orthophosphate( EC:6.3.2.3 )
xref_analog: EC:6.3.2.3
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0100118
xref_analog: IMR:0200102
xref_analog: IMR:0200318
xref_analog: IMR:0200423
xref_analog: KEGG:map00480
xref_analog: KEGG:R00497
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001411 ! Glutamate metabolism

[Term]
id: IEV:0003094
name: L-Cysteine + O2 => L-Cysteine-sulfinic acid( EC:1.13.11.20 )
xref_analog: EC:1.13.11.20
xref_analog: IMR:0200217
xref_analog: IMR:0200402
xref_analog: IMR:0200467
xref_analog: KEGG:map00270
xref_analog: KEGG:map00430
xref_analog: KEGG:R00893
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001466 ! Methionine and Cysteine metabolism

[Term]
id: IEV:0003095
name: 3-Hydroxy-anthranilic acid + O2 => 2-Amino-3-carboxy-muconate semialdehyde( EC:1.13.11.6 )
xref_analog: EC:1.13.11.6
xref_analog: IMR:0200192
xref_analog: IMR:0200217
xref_analog: IMR:0200400
xref_analog: KEGG:map00380
xref_analog: KEGG:R02665
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0003096
name: S-Adenosylmethioninamine + Spermidine => 5'-Methylthio-adenosine + Spermine( EC:2.5.1.22 )
comment: S-Adenosyl-L-methioninamine + Spermidine => 5'-Methylthio-adenosine + Spermine( EC:2.5.1.22 )
xref_analog: EC:2.5.1.22
xref_analog: IMR:0200092
xref_analog: IMR:0200153
xref_analog: IMR:0200175
xref_analog: IMR:0200285
xref_analog: KEGG:map00270
xref_analog: KEGG:map00330
xref_analog: KEGG:map00410
xref_analog: KEGG:map00480
xref_analog: KEGG:R02869
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0003097
name: CoA + ATP + Acetic acid => Acetyl-CoA + AMP + Pyrophosphate( EC:6.2.1.1 )
comment: two-step reaction
xref_analog: EC:6.2.1.1
xref_analog: IMR:0001351
xref_analog: IMR:0200083
xref_analog: IMR:0200208
xref_analog: IMR:0200280
xref_analog: IMR:0200354
xref_analog: IMR:0200414
xref_analog: KEGG:map00010
xref_analog: KEGG:map00720
xref_analog: KEGG:R00235
is_a: IEV:0000394 ! CoA ligation
relationship: part_of IEV:0001424 ! Pyruvate metabolism

[Term]
id: IEV:0003098
name: NADPH + Prostaglandin E2 + H+ => NADP+ + Prostaglandin F2alpha( EC:1.1.1.189 )
comment: NADPH + Prostaglandin E2 => NADP+ + Prostaglandin F2alpha( EC:1.1.1.189 )
xref_analog: EC:1.1.1.189
xref_analog: IMR:0200030
xref_analog: IMR:0200051
xref_analog: IMR:0200067
xref_analog: IMR:0200146
xref_analog: IMR:0200463
xref_analog: KEGG:map00590
xref_analog: KEGG:R02581
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001449 ! Arachidonic acid metabolism

[Term]
id: IEV:0003099
name: 1D-myo-Inositol 3,4-bisphosphate + H2O => 1D-myo-Inositol 3-phosphate + Orthophosphate( EC:3.1.3.66 )
xref_analog: EC:3.1.3.66
xref_analog: IMR:0200102
xref_analog: IMR:0200334
xref_analog: IMR:0200349
xref_analog: IMR:0200357
xref_analog: KEGG:map00562
xref_analog: KEGG:map04070
xref_analog: KEGG:R04372
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0003100
name: (R)-Methyl-malonyl-CoA = Succinyl-CoA( EC:5.4.99.2 )
xref_analog: EC:5.4.99.2
xref_analog: IMR:0200037
xref_analog: IMR:0200515
xref_analog: KEGG:map00280
xref_analog: KEGG:map00640
xref_analog: KEGG:R00833
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001426 ! Propanoate metabolism

[Term]
id: IEV:0003101
name: Uroporphyrinogen I => Coproporphyrinogen I + 4 CO2( EC:4.1.1.37 )
xref_analog: EC:4.1.1.37
xref_analog: IMR:0200131
xref_analog: IMR:0200324
xref_analog: IMR:0200522
xref_analog: KEGG:map00860
xref_analog: KEGG:R04972
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001516 ! Porphyrin and chlorophyll metabolism

[Term]
id: IEV:0003102
name: L-Ornithine => Putrescine + CO2( EC:4.1.1.17 )
xref_analog: EC:4.1.1.17
xref_analog: IMR:0200028
xref_analog: IMR:0200324
xref_analog: IMR:0200342
xref_analog: KEGG:map00330
xref_analog: KEGG:map00480
xref_analog: KEGG:R00670
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0003103
name: S-Adenosyl-L-methionine + Tryptamine => S-Adenosyl-L-homocysteine + N-Methyl-tryptamine( EC:2.1.1.49 )
xref_analog: EC:2.1.1.49
xref_analog: IMR:0200054
xref_analog: IMR:0200128
xref_analog: IMR:0200151
xref_analog: IMR:0200310
xref_analog: KEGG:map00380
xref_analog: KEGG:R02174
is_a: IEV:0002737 ! S-adenosyl-L-methionine + Amine = S-adenosyl-L-homocysteine + Methylated amine( EC:2.1.1.49 )
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0003104
name: N-Acetyl-L-aspartic acid + H2O => L-Aspartic acid + Acetic acid( EC:3.5.1.15 )
xref_analog: EC:3.5.1.15
xref_analog: IMR:0200208
xref_analog: IMR:0200357
xref_analog: IMR:0200459
xref_analog: IMR:0200478
xref_analog: KEGG:map00250
xref_analog: KEGG:R00488
is_a: IEV:0002754 ! N-acyl-L-aspartate + H2O = Carboxylate + L-Aspartic acid( EC:3.5.1.15 )
relationship: part_of IEV:0001410 ! Alanine and aspartate metabolism

[Term]
id: IEV:0003105
name: Histamine + O2 + H2O => Imidazole-4-acetaldehyde + NH3 + H2O2( EC:1.4.3.22 )
comment: Histamine + O2 + H2O => Imidazole-4-acetaldehyde + NH3 + H2O2( EC:1.4.3.6 )
xref_analog: EC:1.4.3.22
xref_analog: IMR:0100125
xref_analog: IMR:0200075
xref_analog: IMR:0200217
xref_analog: IMR:0200352
xref_analog: IMR:0200357
xref_analog: IMR:0200487
xref_analog: KEGG:map00340
xref_analog: KEGG:R02150
is_a: IEV:0002735 ! Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.21 )
relationship: part_of IEV:0001459 ! Histidine metabolism

[Term]
id: IEV:0003106
name: N-Acetyl-alpha-D-glucosamine 1-phosphate = N-Acetyl-D-glucosamine 6-phosphate( EC:5.4.2.3 )
comment: N-Acetyl-D-glucosamine 1-phosphate = N-Acetyl-D-glucosamine 6-phosphate( EC:5.4.2.3 )
xref_analog: EC:5.4.2.3
xref_analog: IMR:0200259
xref_analog: KEGG:C04501
xref_analog: KEGG:map00520
xref_analog: KEGG:R08193
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001421 ! Aminosugars metabolism

[Term]
id: IEV:0003107
name: NADP+ + Hydroxy-acetone = NADPH + Methyl-glyoxal + H+( EC:1.1.1.- )
comment: NAD+ + Hydroxy-acetone = NADH + Methyl-glyoxal( EC:1.1.1.- )
xref_analog: EC:1.1.1.-
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200136
xref_analog: IMR:0200463
xref_analog: IMR:0200471
xref_analog: KEGG:map00260
xref_analog: KEGG:R02528
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism

[Term]
id: IEV:0003108
name: 1D-myo-Inositol 1,4,5-trisphosphate + H2O => 1D-myo-Inositol 1,4-bisphosphate + Orthophosphate( EC:3.1.3.56 )
xref_analog: EC:3.1.3.56
xref_analog: IMR:0100028
xref_analog: IMR:0100698
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: KEGG:map00562
xref_analog: KEGG:map04070
xref_analog: KEGG:R03394
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0003109
name: L-Cysteic acid => Taurine + CO2( EC:4.1.1.15 )
xref_analog: EC:4.1.1.15
xref_analog: IMR:0100120
xref_analog: IMR:0200324
xref_analog: IMR:0200417
xref_analog: KEGG:map00430
xref_analog: KEGG:R01682
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001466 ! Methionine and Cysteine metabolism

[Term]
id: IEV:0003110
name: ATP + beta-D-Fructose 6-phosphate => ADP + beta-D-Fructose 1,6-bisphosphate( EC:2.7.1.11 )
comment: ATP + D-Fructose 6-phosphate => ADP + D-Fructose 1,6-bisphosphate( EC:2.7.1.11 )
xref_analog: EC:2.7.1.11
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: KEGG:C05345
xref_analog: KEGG:C05378
xref_analog: KEGG:map00010
xref_analog: KEGG:map00030
xref_analog: KEGG:map00051
xref_analog: KEGG:R04779
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001413 ! Glycolysis and Gluconeogenesis
relationship: part_of IEV:0001414 ! Pentose phosphate pathway

[Term]
id: IEV:0003111
name: 2 Protoporphyrinogen IX + 3 O2 => 2 Protoporphyrin IX + 6 H2O( EC:1.3.3.4 )
comment: Protoporphyrinogen IX + 1.5 O2 => Protoporphyrin IX + 3 H2O( EC:1.3.3.4 ):multi-step reaction
xref_analog: EC:1.3.3.4
xref_analog: IMR:0200089
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200523
xref_analog: KEGG:map00860
xref_analog: KEGG:R03222
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001516 ! Porphyrin and chlorophyll metabolism

[Term]
id: IEV:0003112
name: ATP + L-Glutamic acid + tRNA(Glu) => AMP + L-Glutamyl-tRNA(Glu) + Pyrophosphate( EC:6.1.1.17 )
xref_analog: EC:6.1.1.17
xref_analog: IMR:0001351
xref_analog: IMR:0100119
xref_analog: IMR:0200083
xref_analog: IMR:0200125
xref_analog: IMR:0200231
xref_analog: IMR:0200280
xref_analog: KEGG:map00860
xref_analog: KEGG:map00970
xref_analog: KEGG:R05578
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001411 ! Glutamate metabolism

[Term]
id: IEV:0003113
name: GDP + Phosphoenol-pyruvic acid => GTP + Pyruvic acid( EC:2.7.1.40 )
xref_analog: EC:2.7.1.40
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: IMR:0200223
xref_analog: IMR:0200331
xref_analog: KEGG:map00230
xref_analog: KEGG:R00430
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003114
name: NAD+ + Indole-3-acetaldehyde + H2O => NADH + Indole-3-acetic acid + H+( EC:1.2.1.3 )
comment: NAD+ + Indole-3-acetaldehyde + H2O => NADH + Indole-3-acetic acid( EC:1.2.1.3 )
xref_analog: EC:1.2.1.3
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: IMR:0200389
xref_analog: IMR:0200416
xref_analog: IMR:0200521
xref_analog: KEGG:map00380
xref_analog: KEGG:R02678
is_a: IEV:0002729 ! Aldehyde + NAD+ + H2O = Carboxylate + NADH + H+( EC:1.2.1.3 )
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0003115
name: P1,P4-Bis(5'-guanosyl) tetraphosphate + H2O => GTP + GMP( EC:3.6.1.17 )
xref_analog: EC:3.6.1.17
xref_analog: IMR:0001354
xref_analog: IMR:0200043
xref_analog: IMR:0200292
xref_analog: IMR:0200357
xref_analog: KEGG:map00230
xref_analog: KEGG:R01232
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003116
name: L-Phenylalanine => Phenyl-ethylamine + CO2( EC:4.1.1.28 )
xref_analog: EC:4.1.1.28
xref_analog: IMR:0200274
xref_analog: IMR:0200324
xref_analog: IMR:0200516
xref_analog: KEGG:map00360
xref_analog: KEGG:R00699
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001461 ! Phenylalanine metabolism

[Term]
id: IEV:0003117
name: ATP + CMP = ADP + CDP( EC:2.7.4.14 )
xref_analog: EC:2.7.4.14
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200468
xref_analog: IMR:0200494
xref_analog: KEGG:map00240
xref_analog: KEGG:R00512
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003118
name: ATP + D-Galactose => ADP + alpha-D-Galactose 1-phosphate( EC:2.7.1.6 )
comment: ATP + D-Galactose => ADP + D-Galactose 1-phosphate( EC:2.7.1.6 )
xref_analog: EC:2.7.1.6
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200123
xref_analog: IMR:0200304
xref_analog: KEGG:map00052
xref_analog: KEGG:map00520
xref_analog: KEGG:R01092
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001418 ! Galactose metabolism

[Term]
id: IEV:0003119
name: CoA + ATP + Acetoacetic acid => Acetoacetyl-CoA + AMP + Pyrophosphate( EC:6.2.1.16 )
xref_analog: EC:6.2.1.16
xref_analog: IMR:0001351
xref_analog: IMR:0200064
xref_analog: IMR:0200083
xref_analog: IMR:0200280
xref_analog: IMR:0200354
xref_analog: IMR:0200410
xref_analog: KEGG:map00650
xref_analog: KEGG:R01357
is_a: IEV:0000394 ! CoA ligation
relationship: part_of IEV:0001427 ! Butanoate metabolism

[Term]
id: IEV:0003120
name: UDP + H2O => UMP + Orthophosphate( EC:3.6.1.5 )
xref_analog: EC:3.6.1.5
xref_analog: IMR:0200102
xref_analog: IMR:0200206
xref_analog: IMR:0200357
xref_analog: IMR:0200409
xref_analog: KEGG:map00240
xref_analog: KEGG:R00155
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003121
name: NAD+ + 3,4-Dihydroxy-mandelaldehyde + H2O = NADH + 3,4-Dihydroxy-mandelic acid + H+( EC:1.2.1.5 )
comment: NAD+ + 3,4-Dihydroxy-mandelaldehyde + H2O = NADH + 3,4-Dihydroxy-mandelic acid( EC:1.2.1.5 )
xref_analog: EC:1.2.1.5
xref_analog: IMR:0200030
xref_analog: IMR:0200068
xref_analog: IMR:0200248
xref_analog: IMR:0200289
xref_analog: IMR:0200357
xref_analog: IMR:0200521
xref_analog: KEGG:map00350
xref_analog: KEGG:R04882
is_a: IEV:0002730 ! Aldehyde + NADP+ + H2O = Carboxylate + NADPH + H+( EC:1.2.1.5 )
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0003122
name: Galactan + H2O => 2 D-Galactose( EC:3.2.1.23 )
comment: notice: Galactan + H2O <=> D-Galactose + Galactan( EC:3.2.1.23 )
xref_analog: EC:3.2.1.23
xref_analog: IMR:0200085
xref_analog: IMR:0200123
xref_analog: IMR:0200357
xref_analog: KEGG:map00052
xref_analog: KEGG:R01105
is_a: IEV:0002753 ! Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides( EC:3.2.1.23 )
relationship: part_of IEV:0001418 ! Galactose metabolism

[Term]
id: IEV:0003123
name: D-Glucose 6-phosphate => D-myo-Inositol 3-phosphate( EC:5.5.1.4 )
comment: D-Glucose 6-phosphate => D-myo-Inositol 1-phosphate( EC:5.5.1.4 )
xref_analog: EC:5.5.1.4
xref_analog: IMR:0200349
xref_analog: IMR:0200430
xref_analog: KEGG:map00521
xref_analog: KEGG:map00562
xref_analog: KEGG:R07324
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0003124
name: N-Acetyl-putrescine + H2O + O2 => N4-Acetylaminobutanal + NH3 + H2O2( EC:1.4.3.4 )
comment: N-Acetyl-putrescine + H2O + O2 => N4-Acetyl-amino-butyraldehyde + NH3 + H2O2( EC:1.4.3.4 )
xref_analog: EC:1.4.3.4
xref_analog: IMR:0200075
xref_analog: IMR:0200217
xref_analog: IMR:0200333
xref_analog: IMR:0200357
xref_analog: IMR:0200421
xref_analog: IMR:0200487
xref_analog: KEGG:map00330
xref_analog: KEGG:R04025
is_a: IEV:0002734 ! Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.4 )
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0003125
name: NAD+ + 2-Hydroxy-butanoic acid = NADH + 2-Oxo-butanoic acid + H+( EC:1.1.1.27 )
comment: NAD+ + 2-Hydroxy-butanoic acid = NADH + 2-Oxo-butanoic acid( EC:1.1.1.27 )
xref_analog: EC:1.1.1.27
xref_analog: IMR:0200030
xref_analog: IMR:0200127
xref_analog: IMR:0200219
xref_analog: IMR:0200248
xref_analog: IMR:0200521
xref_analog: KEGG:map00640
xref_analog: KEGG:R01000
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001426 ! Propanoate metabolism

[Term]
id: IEV:0003126
name: 5-Hydroxy-N-formyl-kynurenine + H2O => 5-Hydroxy-kynurenine + Formic acid( EC:3.5.1.9 )
xref_analog: EC:3.5.1.9
xref_analog: IMR:0200110
xref_analog: IMR:0200357
xref_analog: IMR:0200411
xref_analog: IMR:0200491
xref_analog: KEGG:map00380
xref_analog: KEGG:R04911
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0003127
name: ATP + dADP = ADP + dATP( EC:2.7.4.6 )
xref_analog: EC:2.7.4.6
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200129
xref_analog: IMR:0200237
xref_analog: KEGG:map00230
xref_analog: KEGG:R01137
is_a: IEV:0002907 ! ATP + Nucleoside diphosphate = ADP + Nucleoside triphosphate( EC:2.7.4.6 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003128
name: L-Cystine + H2O => Thiocysteine + Pyruvic acid + NH3( EC:4.4.1.1 )
xref_analog: EC:4.4.1.1
xref_analog: IMR:0200075
xref_analog: IMR:0200331
xref_analog: IMR:0200357
xref_analog: IMR:0200440
xref_analog: IMR:0200475
xref_analog: KEGG:map00270
xref_analog: KEGG:R02408
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001466 ! Methionine and Cysteine metabolism

[Term]
id: IEV:0003129
name: S-Adenosyl-L-methionine + Phosphatidyl-ethanolamine => S-Adenosyl-L-homocysteine + Phosphatidyl-N-methyl-ethanolamine( EC:2.1.1.17 )
xref_analog: EC:2.1.1.17
xref_analog: IMR:0200054
xref_analog: IMR:0200151
xref_analog: IMR:0200317
xref_analog: IMR:0200361
xref_analog: KEGG:map00564
xref_analog: KEGG:R02056
is_a: IEV:0000433 ! Transmethylation
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism

[Term]
id: IEV:0003130
name: Orotidine 5'-phosphate => UMP + CO2( EC:4.1.1.23 )
comment: 5'-Orotidylic acid => UMP + CO2( EC:4.1.1.23 )
xref_analog: EC:4.1.1.23
xref_analog: IMR:0200087
xref_analog: IMR:0200324
xref_analog: IMR:0200409
xref_analog: KEGG:map00240
xref_analog: KEGG:R00965
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003131
name: Nicotinate D-ribonucleoside + Orthophosphate = Nicotinic acid + D-Ribose 1-phosphate( EC:2.4.2.1 )
xref_analog: EC:2.4.2.1
xref_analog: IMR:0200102
xref_analog: IMR:0200104
xref_analog: IMR:0200415
xref_analog: KEGG:C00620
xref_analog: KEGG:map00760
xref_analog: KEGG:R02295
is_a: IEV:0002742 ! purine nucleoside + Orthophosphate = purine + D-ribose 1-phosphate( EC:2.4.2.1 )
relationship: part_of IEV:0001510 ! Nicotinate and nicotinamide metabolism

[Term]
id: IEV:0003132
name: CTP + N-Glycolyl-neuraminic acid => Pyrophosphate + CMP-N-glycolyl-neuraminic acid( EC:2.7.7.43 )
xref_analog: EC:2.7.7.43
xref_analog: IMR:0200024
xref_analog: IMR:0200172
xref_analog: IMR:0200202
xref_analog: IMR:0200280
xref_analog: KEGG:map00520
xref_analog: KEGG:R04215
is_a: IEV:0002748 ! CTP + N-acylneuraminate = Pyrophosphate + CMP-N-acylneuraminate( EC:2.7.7.43 )
relationship: part_of IEV:0001421 ! Aminosugars metabolism

[Term]
id: IEV:0003133
name: Tryptamine + O2 + H2O => Indole-3-acetaldehyde + H2O2 + NH3( EC:1.4.3.22 )
comment: Tryptamine + O2 + H2O => Indole-3-acetaldehyde + H2O2 + NH3( EC:1.4.3.6 )
xref_analog: EC:1.4.3.22
xref_analog: IMR:0200075
xref_analog: IMR:0200128
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200416
xref_analog: IMR:0200487
xref_analog: KEGG:map00380
xref_analog: KEGG:R02173
is_a: IEV:0002735 ! Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.21 )
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0003134
name: XMP + H2O => Xanthosine + Orthophosphate( EC:3.1.3.5 )
xref_analog: EC:3.1.3.5
xref_analog: IMR:0200102
xref_analog: IMR:0200165
xref_analog: IMR:0200357
xref_analog: IMR:0200426
xref_analog: KEGG:map00230
xref_analog: KEGG:R02719
is_a: IEV:0002751 ! 5'-ribonucleotide + H2O = ribonucleoside + phosphate( EC:3.1.3.5 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003135
name: ATP + GDP = ADP + GTP( EC:2.7.4.6 )
xref_analog: EC:2.7.4.6
xref_analog: IMR:0001351
xref_analog: IMR:0001354
xref_analog: IMR:0001357
xref_analog: IMR:0001360
xref_analog: KEGG:map00230
xref_analog: KEGG:R00330
is_a: IEV:0002907 ! ATP + Nucleoside diphosphate = ADP + Nucleoside triphosphate( EC:2.7.4.6 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003136
name: Isopentenyl diphosphate + Geranyl diphosphate => Farnesyl diphosphate + Pyrophosphate( EC:2.5.1.10 )
xref_analog: EC:2.5.1.10
xref_analog: IMR:0200097
xref_analog: IMR:0200280
xref_analog: IMR:0200287
xref_analog: IMR:0200399
xref_analog: KEGG:map00900
xref_analog: KEGG:R02003
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001443 ! Steroid biosynthesis

[Term]
id: IEV:0003137
name: (S)-3-Hydroxyisobutyryl-CoA = 2-Methylprop-2-enoyl-CoA + H2O( EC:4.2.1.17 )
comment: (S)-3-Hydroxy-2-methyl-propanoyl-CoA = 2-Methylprop-2-enoyl-CoA + H2O( EC:4.2.1.17 )
xref_analog: EC:4.2.1.17
xref_analog: IMR:0200164
xref_analog: IMR:0200357
xref_analog: IMR:0200434
xref_analog: KEGG:map00280
xref_analog: KEGG:R04224
is_a: IEV:0002759 ! (3S)-3-hydroxyacyl-CoA = trans-2,3-Dehydroacyl-CoA + H2O( EC:4.2.1.17 )
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0003138
name: Tyramine + O2 + H2O => 4-Hydroxy-phenyl-acetaldehyde + H2O2 + NH3( EC:1.4.3.21 )
comment: Tyramine + O2 + H2O => 4-Hydroxy-phenyl-acetaldehyde + H2O2 + NH3( EC:1.4.3.6 )
xref_analog: EC:1.4.3.21
xref_analog: IMR:0100124
xref_analog: IMR:0200040
xref_analog: IMR:0200075
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200487
xref_analog: KEGG:map00350
xref_analog: KEGG:R02382
is_a: IEV:0002735 ! Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.21 )
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0003139
name: 2 ATP + L-Glutamine + HCO3- + H2O = 2 ADP + L-Glutamic acid + Carbamoyl phosphate + Orthophosphate( EC:6.3.5.5 )
comment: ATP + L-Glutamine + CO2 + 2 H2O => ADP + L-Glutamic acid + Carbamic acid + Orthophosphate( EC:6.3.5.5 ): two-step reaction.
xref_analog: EC:6.3.5.5
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0100119
xref_analog: IMR:0200102
xref_analog: IMR:0200109
xref_analog: IMR:0200357
xref_analog: IMR:0200448
xref_analog: KEGG:C00288
xref_analog: KEGG:map00240
xref_analog: KEGG:map00250
xref_analog: KEGG:R00575
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001411 ! Glutamate metabolism

[Term]
id: IEV:0003140
name: 4-Trimethyl-ammonio-butanoic acid + 2-Oxo-glutaric acid + O2 => Carnitine + Succinic acid + CO2( EC:1.14.11.1 )
xref_analog: EC:1.14.11.1
xref_analog: IMR:0200035
xref_analog: IMR:0200119
xref_analog: IMR:0200168
xref_analog: IMR:0200217
xref_analog: IMR:0200324
xref_analog: IMR:0200480
xref_analog: KEGG:map00310
xref_analog: KEGG:R02397
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001457 ! Lysine degradation

[Term]
id: IEV:0003141
name: S-Adenosyl-L-methionine + N-Acetyl-serotonin => S-Adenosyl-L-homocysteine + Melatonin( EC:2.1.1.4 )
xref_analog: EC:2.1.1.4
xref_analog: IMR:0100069
xref_analog: IMR:0200054
xref_analog: IMR:0200151
xref_analog: IMR:0200180
xref_analog: KEGG:map00380
xref_analog: KEGG:R03130
is_a: IEV:0000433 ! Transmethylation
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0003142
name: ATP + beta-D-Fructose 6-phosphate => ADP + D-Fructose 2,6-bisphosphate( EC:2.7.1.105 )
comment: ATP + D-Fructose 6-phosphate => ADP + D-Fructose 2,6-bisphosphate( EC:2.7.1.105 )
xref_analog: EC:2.7.1.105
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200263
xref_analog: KEGG:C05345
xref_analog: KEGG:map00051
xref_analog: KEGG:R02732
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001417 ! Fructose and mannose metabolism

[Term]
id: IEV:0003143
name: L-Histidine => Histamine + CO2( EC:4.1.1.22 )
xref_analog: EC:4.1.1.22
xref_analog: IMR:0100125
xref_analog: IMR:0200137
xref_analog: IMR:0200324
xref_analog: KEGG:map00340
xref_analog: KEGG:R01167
is_a: IEV:0001067 ! Decarboxylation
relationship: part_of IEV:0001459 ! Histidine metabolism

[Term]
id: IEV:0003144
name: dADP + Phosphoenol-pyruvic acid => dATP + Pyruvic acid( EC:2.7.1.40 )
xref_analog: EC:2.7.1.40
xref_analog: IMR:0200129
xref_analog: IMR:0200223
xref_analog: IMR:0200237
xref_analog: IMR:0200331
xref_analog: KEGG:map00230
xref_analog: KEGG:R01138
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003145
name: Butanoyl-CoA + NAD+ = Crotonoyl-CoA + NADH + H+( EC:1.3.99.2 )
comment: Butanoyl-CoA + Acceptor = Crotonoyl-CoA + Reduced acceptor( EC:1.3.99.2 )
xref_analog: EC:1.3.99.2
xref_analog: IMR:0200030
xref_analog: IMR:0200121
xref_analog: IMR:0200195
xref_analog: IMR:0200248
xref_analog: IMR:0200521
xref_analog: KEGG:map00650
xref_analog: KEGG:R01171
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001427 ! Butanoate metabolism

[Term]
id: IEV:0003146
name: NAD+ + Isocitric acid = NADH + 2-Oxo-glutaric acid + CO2 + H+( EC:1.1.1.41 )
comment: NAD+ + Isocitric acid = NADH + 2-Oxo-glutaric acid + CO2( EC:1.1.1.41 )
xref_analog: EC:1.1.1.41
xref_analog: IMR:0200023
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200324
xref_analog: IMR:0200480
xref_analog: IMR:0200521
xref_analog: KEGG:map00020
xref_analog: KEGG:R00709
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001415 ! Citrate cycle (TCA cycle)

[Term]
id: IEV:0003147
name: Dopamine + H2O + O2 => 3,4-Dihydroxy-phenyl-acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
xref_analog: EC:1.4.3.4
xref_analog: IMR:0100113
xref_analog: IMR:0200075
xref_analog: IMR:0200217
xref_analog: IMR:0200346
xref_analog: IMR:0200357
xref_analog: IMR:0200487
xref_analog: KEGG:map00350
xref_analog: KEGG:map00950
xref_analog: KEGG:R04300
is_a: IEV:0002734 ! Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.4 )
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0003148
name: 5-Hydroxy-indole-acetic acid => 5-Hydroxy-indole-acetylglycine( EC:6.3.2.- )
comment: ATP + 5-Hydroxy-indole-acetic acid + Glycine => ADP + 5-Hydroxy-indole-acetylglycine + Orthophosphate( EC:6.3.2.- )
xref_analog: EC:6.3.2.-
xref_analog: IMR:0200010
xref_analog: IMR:0200052
xref_analog: KEGG:map00380
xref_analog: KEGG:R04906
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0003149
name: NADPH + 5alpha-Cholest-7-en-3beta-ol + O2 + H+ => NADP+ + 7-Dehydro-cholesterol + 2 H2O( EC:1.14.21.6 )
comment: NADPH + 5-cholest-7-en-3-ol + O2 => NADP+ + 7-Dehydro-cholesterol + H2O2( EC:1.14.21.6 )
xref_analog: EC:1.14.21.6
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200217
xref_analog: IMR:0200296
xref_analog: IMR:0200357
xref_analog: IMR:0200463
xref_analog: IMR:0200510
xref_analog: KEGG:map00100
xref_analog: KEGG:R07215
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001443 ! Steroid biosynthesis

[Term]
id: IEV:0003150
name: UMP + H2O => Uridine + Orthophosphate( EC:3.1.3.5 )
xref_analog: EC:3.1.3.5
xref_analog: IMR:0200021
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: IMR:0200409
xref_analog: KEGG:map00240
xref_analog: KEGG:R00963
is_a: IEV:0002751 ! 5'-ribonucleotide + H2O = ribonucleoside + phosphate( EC:3.1.3.5 )
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003151
name: ATP + L-Threonine + tRNA(Thr) => AMP + L-Threonyl-tRNA(Thr) + Pyrophosphate( EC:6.1.1.3 )
xref_analog: EC:6.1.1.3
xref_analog: IMR:0001351
xref_analog: IMR:0200083
xref_analog: IMR:0200154
xref_analog: IMR:0200280
xref_analog: IMR:0200444
xref_analog: IMR:0200502
xref_analog: KEGG:map00970
xref_analog: KEGG:R03663
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism

[Term]
id: IEV:0003152
name: (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA = 2-Methylbut-2-enoyl-CoA + H2O( EC:4.2.1.17 )
comment: (S)-3-Hydroxy-2-methyl-butanoyl-CoA = 2-Methylbut-2-enoyl-CoA + H2O( EC:4.2.1.17 )
xref_analog: EC:4.2.1.17
xref_analog: IMR:0200207
xref_analog: IMR:0200357
xref_analog: IMR:0200465
xref_analog: KEGG:map00280
xref_analog: KEGG:R04204
is_a: IEV:0002759 ! (3S)-3-hydroxyacyl-CoA = trans-2,3-Dehydroacyl-CoA + H2O( EC:4.2.1.17 )
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0003153
name: NAD+ + 3,4-Dihydroxy-phenyl-acetaldehyde + H2O = NADH + 3,4-Dihydroxy-phenyl-acetic acid + H+( EC:1.2.1.5 )
comment: NAD+ + 3,4-Dihydroxy-phenyl-acetaldehyde + H2O = NADH + 3,4-Dihydroxy-phenyl-acetic acid( EC:1.2.1.5 )
xref_analog: EC:1.2.1.5
xref_analog: IMR:0200026
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200346
xref_analog: IMR:0200357
xref_analog: IMR:0200521
xref_analog: KEGG:map00350
xref_analog: KEGG:R03300
is_a: IEV:0002730 ! Aldehyde + NADP+ + H2O = Carboxylate + NADPH + H+( EC:1.2.1.5 )
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0003154
name: Acetyl phosphate + H2O = Acetic acid + Orthophosphate( EC:3.6.1.7 )
xref_analog: EC:3.6.1.7
xref_analog: IMR:0200102
xref_analog: IMR:0200208
xref_analog: IMR:0200266
xref_analog: IMR:0200357
xref_analog: KEGG:map00620
xref_analog: KEGG:R00317
is_a: IEV:0002757 ! Acylphosphate + H2O = Carboxylate + phosphate( EC:3.6.1.7 )
relationship: part_of IEV:0001424 ! Pyruvate metabolism

[Term]
id: IEV:0003155
name: ATP + Deamido-NAD+ + L-Glutamine + H2O => AMP + NAD+ + L-Glutamic acid + Pyrophosphate( EC:6.3.5.1 )
xref_analog: EC:6.3.5.1
xref_analog: IMR:0001351
xref_analog: IMR:0100119
xref_analog: IMR:0200082
xref_analog: IMR:0200083
xref_analog: IMR:0200248
xref_analog: IMR:0200280
xref_analog: IMR:0200357
xref_analog: IMR:0200448
xref_analog: KEGG:map00760
xref_analog: KEGG:R00257
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001510 ! Nicotinate and nicotinamide metabolism

[Term]
id: IEV:0003156
name: ATP + Pyridoxine => ADP + Pyridoxine 5'-phosphate( EC:2.7.1.35 )
xref_analog: EC:2.7.1.35
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200344
xref_analog: IMR:0200429
xref_analog: KEGG:map00750
xref_analog: KEGG:R01909
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001509 ! Vitamin B6 metabolism

[Term]
id: IEV:0003157
name: AMP + H2O => Adenosine + Orthophosphate( EC:3.1.3.5 )
xref_analog: EC:3.1.3.5
xref_analog: IMR:0100126
xref_analog: IMR:0200083
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: KEGG:map00230
xref_analog: KEGG:R00183
is_a: IEV:0002751 ! 5'-ribonucleotide + H2O = ribonucleoside + phosphate( EC:3.1.3.5 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003158
name: NADH + (S)-1-Pyrroline-5-carboxylic acid + H+ = NAD+ + L-Proline( EC:1.5.1.2 )
comment: NADH + (S)-1-Pyrroline-5-carboxylic acid = NAD+ + L-Proline( EC:1.5.1.2 )
xref_analog: EC:1.5.1.2
xref_analog: IMR:0200030
xref_analog: IMR:0200183
xref_analog: IMR:0200236
xref_analog: IMR:0200248
xref_analog: IMR:0200521
xref_analog: KEGG:map00330
xref_analog: KEGG:R01248
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0003159
name: Tryptamine + H2O + O2 => Indole-3-acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
xref_analog: EC:1.4.3.4
xref_analog: IMR:0200075
xref_analog: IMR:0200128
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200416
xref_analog: IMR:0200487
xref_analog: KEGG:map00380
xref_analog: KEGG:R02173
is_a: IEV:0002734 ! Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.4 )
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0003160
name: 2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine => TPP + [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine( EC:1.2.4.1 )
comment: 2-(Hydroxyethyl)-thiamine diphosphate + Lipoamide => TPP + 6-S-Acetyl-dihydro-lipoamide( EC:1.2.4.1 )
xref_analog: EC:1.2.4.1
xref_analog: IMR:0200055
xref_analog: IMR:0200378
xref_analog: KEGG:C15972
xref_analog: KEGG:C16255
xref_analog: KEGG:map00010
xref_analog: KEGG:map00020
xref_analog: KEGG:map00620
xref_analog: KEGG:R03270
relationship: part_of IEV:0002762 ! Pyruvic acid + Enzyme N6-(lipoyl)lysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2( EC:1.2.4.1 )

[Term]
id: IEV:0003161
name: S-Adenosyl-L-methionine + Serotonin => S-Adenosyl-L-homocysteine + N-Methyl-serotonin( EC:2.1.1.49 )
xref_analog: EC:2.1.1.49
xref_analog: IMR:0100123
xref_analog: IMR:0200054
xref_analog: IMR:0200151
xref_analog: IMR:0200386
xref_analog: KEGG:map00380
xref_analog: KEGG:R02910
is_a: IEV:0002737 ! S-adenosyl-L-methionine + Amine = S-adenosyl-L-homocysteine + Methylated amine( EC:2.1.1.49 )
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0003162
name: 2-Oxo-glutaric acid + L-Isoleucine = L-Glutamic acid + (S)-3-Methyl-2-oxopentanoic acid( EC:2.6.1.42 )
comment: 2-Oxo-glutaric acid + L-Isoleucine = L-Glutamic acid + (R)-2-Oxo-3-methyl-pentanoic acid( EC:2.6.1.42 )
xref_analog: EC:2.6.1.42
xref_analog: IMR:0100119
xref_analog: IMR:0200272
xref_analog: IMR:0200480
xref_analog: KEGG:C00671
xref_analog: KEGG:map00280
xref_analog: KEGG:map00290
xref_analog: KEGG:map00966
xref_analog: KEGG:R02199
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0003163
name: 2-Oxo-glutaric acid + L-O-Phospho-serine = L-Glutamic acid + 3-Phospho-hydroxy-pyruvic acid( EC:2.6.1.52 )
xref_analog: EC:2.6.1.52
xref_analog: IMR:0100119
xref_analog: IMR:0200329
xref_analog: IMR:0200427
xref_analog: IMR:0200480
xref_analog: KEGG:map00260
xref_analog: KEGG:R04173
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism

[Term]
id: IEV:0003164
name: ATP + CoA + Citric acid = ADP + Acetyl-CoA + Oxaloacetic acid + Orthophosphate( EC:2.3.3.8 )
comment: multi-step reaction
xref_analog: EC:2.3.3.8
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200102
xref_analog: IMR:0200339
xref_analog: IMR:0200354
xref_analog: IMR:0200414
xref_analog: IMR:0200473
xref_analog: KEGG:map00020
xref_analog: KEGG:map00720
xref_analog: KEGG:R00352
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001415 ! Citrate cycle (TCA cycle)

[Term]
id: IEV:0003165
name: UDP-D-galactose + D-Glucose => UDP + Lactose( EC:2.4.1.22 )
xref_analog: EC:2.4.1.22
xref_analog: IMR:0200042
xref_analog: IMR:0200206
xref_analog: IMR:0200227
xref_analog: IMR:0200277
xref_analog: KEGG:map00052
xref_analog: KEGG:R00503
is_a: IEV:0002560 ! Glycosylation
relationship: part_of IEV:0001418 ! Galactose metabolism

[Term]
id: IEV:0003166
name: NAD+ + L-2-Amino-adipate 6-semialdehyde + H2O = NADH + L-2-Amino-adipic acid + H+( EC:1.2.1.31 )
comment: NAD+ + L-2-Amino-adipate 6-semialdehyde + H2O = NADH + L-2-Amino-adipic acid( EC:1.2.1.31 )
xref_analog: EC:1.2.1.31
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200294
xref_analog: IMR:0200322
xref_analog: IMR:0200357
xref_analog: IMR:0200521
xref_analog: KEGG:map00310
xref_analog: KEGG:R03102
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001457 ! Lysine degradation

[Term]
id: IEV:0003167
name: ATP + L-Proline + tRNA(Pro) => AMP + L-Prolyl-tRNA(Pro) + Pyrophosphate( EC:6.1.1.15 )
xref_analog: EC:6.1.1.15
xref_analog: IMR:0001351
xref_analog: IMR:0200001
xref_analog: IMR:0200083
xref_analog: IMR:0200183
xref_analog: IMR:0200280
xref_analog: IMR:0200359
xref_analog: KEGG:map00970
xref_analog: KEGG:R03661
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0003168
name: ATP + Adenosine => ADP + AMP( EC:2.7.1.20 )
xref_analog: EC:2.7.1.20
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0100126
xref_analog: IMR:0200083
xref_analog: KEGG:map00230
xref_analog: KEGG:R00185
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003169
name: 2 Farnesyl diphosphate + NADPH + H+ => NADP+ + Squalene + 2 Pyrophosphate( EC:2.5.1.21 )
comment: 2 Farnesyl diphosphate + NADPH => NADP+ + Squalene + 2 Pyrophosphate( EC:2.5.1.21 ):two-step reaction
xref_analog: EC:2.5.1.21
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200097
xref_analog: IMR:0200280
xref_analog: IMR:0200463
xref_analog: IMR:0200481
xref_analog: KEGG:R06223
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001443 ! Steroid biosynthesis

[Term]
id: IEV:0003170
name: NAD+ + 3-Mercapto-lactic acid = NADH + 3-Mercapto-pyruvic acid + H+( EC:1.1.1.27 )
comment: NAD+ + 3-Mercapto-lactic acid = NADH + 3-Mercapto-pyruvic acid( EC:1.1.1.27 )
xref_analog: EC:1.1.1.27
xref_analog: IMR:0200007
xref_analog: IMR:0200030
xref_analog: IMR:0200248
xref_analog: IMR:0200498
xref_analog: IMR:0200521
xref_analog: KEGG:map00270
xref_analog: KEGG:R03104
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001466 ! Methionine and Cysteine metabolism

[Term]
id: IEV:0003171
name: UDP-N-acetyl-D-glucosamine + H2O => UDP + N-acetyl-D-mannosamine( EC:5.1.3.14 )
xref_analog: EC:5.1.3.14
xref_analog: IMR:0200206
xref_analog: IMR:0200247
xref_analog: IMR:0200282
xref_analog: IMR:0200357
xref_analog: KEGG:map00520
xref_analog: KEGG:R00414
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001421 ! Aminosugars metabolism

[Term]
id: IEV:0003172
name: NADPH + Cholesterol + O2 + H+ = NADP+ + 7alpha-Hydroxycholesterol + H2O( EC:1.14.13.17 )
comment: NADPH + Cholesterol + O2 = NADP+ + 7-Hydroxy-cholesterol + H2O( EC:1.14.13.17 )
xref_analog: EC:1.14.13.17
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200404
xref_analog: IMR:0200463
xref_analog: IMR:0200486
xref_analog: KEGG:map00120
xref_analog: KEGG:R01463
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001443 ! Steroid biosynthesis

[Term]
id: IEV:0003173
name: Putrescine + O2 + H2O => 4-Amino-butyraldehyde + H2O2 + NH3( EC:1.4.3.22 )
comment: Putrescine + O2 + H2O => 4-Amino-butyraldehyde + H2O2 + NH3( EC:1.4.3.6 )
xref_analog: EC:1.4.3.22
xref_analog: IMR:0200028
xref_analog: IMR:0200075
xref_analog: IMR:0200142
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200487
xref_analog: KEGG:map00330
xref_analog: KEGG:R01151
is_a: IEV:0002735 ! Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.21 )
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0003175
name: ATP + L-Glutamine + L-Aspartic acid + H2O => AMP + L-Glutamic acid + L-Asparagine + Pyrophosphate( EC:6.3.5.4 )
xref_analog: EC:6.3.5.4
xref_analog: IMR:0001351
xref_analog: IMR:0100119
xref_analog: IMR:0200083
xref_analog: IMR:0200113
xref_analog: IMR:0200280
xref_analog: IMR:0200357
xref_analog: IMR:0200448
xref_analog: IMR:0200459
xref_analog: KEGG:map00250
xref_analog: KEGG:map00910
xref_analog: KEGG:R00578
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001410 ! Alanine and aspartate metabolism

[Term]
id: IEV:0003176
name: NADPH + GMP + H+ => NADP+ + IMP + NH3( EC:1.7.1.7 )
comment: NADPH + GMP => NADP+ + IMP + NH3( EC:1.7.1.7 )
xref_analog: EC:1.7.1.7
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200075
xref_analog: IMR:0200221
xref_analog: IMR:0200292
xref_analog: IMR:0200463
xref_analog: KEGG:map00230
xref_analog: KEGG:R01134
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003177
name: Acetyl-CoA + Putrescine => CoA + N-Acetyl-putrescine( EC:2.3.1.57 )
xref_analog: EC:2.3.1.57
xref_analog: IMR:0200028
xref_analog: IMR:0200333
xref_analog: IMR:0200354
xref_analog: IMR:0200414
xref_analog: KEGG:map00330
xref_analog: KEGG:R01154
is_a: IEV:0003314 ! Acetyl-CoA + alkane-alpha,omega-diamine = CoA + N-acetyldiamine( EC:2.3.1.57 )
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0003178
name: 5-Formimino-tetrahydro-folic acid + H+ = 5,10-Methenyl-tetrahydro-folic acid + NH3( EC:4.3.1.4 )
comment: 5-Formimino-tetrahydro-folic acid = 5,10-Methenyl-tetrahydro-folic acid + NH3( EC:4.3.1.4 )
xref_analog: EC:4.3.1.4
xref_analog: IMR:0200030
xref_analog: IMR:0200075
xref_analog: IMR:0200159
xref_analog: IMR:0200443
xref_analog: KEGG:map00670
xref_analog: KEGG:R02302
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0003179
name: ATP + GMP = ADP + GDP( EC:2.7.4.8 )
xref_analog: EC:2.7.4.8
xref_analog: IMR:0001351
xref_analog: IMR:0001357
xref_analog: IMR:0001360
xref_analog: IMR:0200292
xref_analog: KEGG:map00230
xref_analog: KEGG:R00332
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003180
name: 1D-myo-Inositol 3-phosphate + H2O => myo-Inositol + Orthophosphate( EC:3.1.3.25 )
xref_analog: EC:3.1.3.25
xref_analog: IMR:0200102
xref_analog: IMR:0200177
xref_analog: IMR:0200349
xref_analog: IMR:0200357
xref_analog: KEGG:map00521
xref_analog: KEGG:map00562
xref_analog: KEGG:map04070
xref_analog: KEGG:R01187
is_a: IEV:0002750 ! myo-inositol phosphate + H2O = myo-inositol + Orthophosphate( EC:3.1.3.25 )
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0003181
name: TPP + Pyruvic acid => 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2( EC:1.2.4.1 )
comment: TPP + Pyruvic acid => 2-(Hydroxyethyl)-thiamine diphosphate + CO2( EC:1.2.4.1 ):subsequently IEV:0003160
xref_analog: EC:1.2.4.1
xref_analog: IMR:0200055
xref_analog: IMR:0200324
xref_analog: IMR:0200331
xref_analog: IMR:0200378
xref_analog: KEGG:map00010
xref_analog: KEGG:map00020
xref_analog: KEGG:map00290
xref_analog: KEGG:map00620
xref_analog: KEGG:map00650
xref_analog: KEGG:R00014
relationship: part_of IEV:0002762 ! Pyruvic acid + Enzyme N6-(lipoyl)lysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2( EC:1.2.4.1 )

[Term]
id: IEV:0003182
name: D-Glucono-1,5-lactone 6-phosphate + H2O => 6-Phospho-D-gluconic acid( EC:3.1.1.31 )
comment: D-6-Phospho-glucono 1,5-lactone + H2O => 6-Phospho-D-gluconic acid( EC:3.1.1.31 )
xref_analog: EC:3.1.1.31
xref_analog: IMR:0200059
xref_analog: IMR:0200357
xref_analog: IMR:0200508
xref_analog: KEGG:map00030
xref_analog: KEGG:R02035
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001414 ! Pentose phosphate pathway

[Term]
id: IEV:0003183
name: ATP + 5'-Phospho-ribosyl-N-formyl-glycinamide + L-Glutamine + H2O => ADP + 5'-Phospho-ribosyl-N-formyl-glycinamidine + L-Glutamic acid + Orthophosphate( EC:6.3.5.3 )
xref_analog: EC:6.3.5.3
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0100119
xref_analog: IMR:0200022
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: IMR:0200398
xref_analog: IMR:0200448
xref_analog: KEGG:map00230
xref_analog: KEGG:R04463
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003184
name: 5-Hydroxy-L-Tryptophan + O2 => 5-Hydroxy-N-formyl-kynurenine( EC:1.13.11.52 )
comment: 5-Hydroxy-L-Tryptophan + O2 => 5-Hydroxy-N-formyl-kynurenine( EC:1.13.11.42 )
xref_analog: EC:1.13.11.52
xref_analog: IMR:0200112
xref_analog: IMR:0200217
xref_analog: IMR:0200411
xref_analog: KEGG:map00380
xref_analog: KEGG:R02702
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0003185
name: 2 5-Amino-4-oxo-pentanoic acid => Porphobilinogen + 2 H2O( EC:4.2.1.24 )
xref_analog: EC:4.2.1.24
xref_analog: IMR:0200264
xref_analog: IMR:0200357
xref_analog: IMR:0200436
xref_analog: KEGG:map00860
xref_analog: KEGG:R00036
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001516 ! Porphyrin and chlorophyll metabolism

[Term]
id: IEV:0003186
name: IMP + H2O = 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide( EC:3.5.4.10 )
comment: IMP + H2O = 5'-Phospho-ribosyl-4-carboxamido-5-formamido-imidazole( EC:3.5.4.10 )
xref_analog: EC:3.5.4.10
xref_analog: IMR:0200221
xref_analog: IMR:0200357
xref_analog: IMR:0200452
xref_analog: KEGG:map00230
xref_analog: KEGG:R01127
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003187
name: dUTP + H2O => dUMP + Pyrophosphate( EC:3.6.1.19 )
xref_analog: EC:3.6.1.19
xref_analog: IMR:0200008
xref_analog: IMR:0200056
xref_analog: IMR:0200280
xref_analog: IMR:0200357
xref_analog: KEGG:map00240
xref_analog: KEGG:R02100
is_a: IEV:0002755 ! Nucleoside triphosphate + H2O = Nucleotide + diphosphate( EC:3.6.1.19 )
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003188
name: ATP + L-Glutamic acid + L-Cysteine => ADP + gamma-L-Glutamyl-L-cysteine + Orthophosphate( EC:6.3.2.2 )
comment: ATP + L-Glutamic acid + L-Cysteine => ADP + 5-L-Glutamyl-cysteine + Orthophosphate( EC:6.3.2.2 )
xref_analog: EC:6.3.2.2
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0100119
xref_analog: IMR:0200102
xref_analog: IMR:0200423
xref_analog: IMR:0200467
xref_analog: KEGG:map00480
xref_analog: KEGG:R00894
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001411 ! Glutamate metabolism

[Term]
id: IEV:0003189
name: ATP + dUDP = ADP + dUTP( EC:2.7.4.6 )
xref_analog: EC:2.7.4.6
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200056
xref_analog: IMR:0200098
xref_analog: KEGG:map00240
xref_analog: KEGG:R02331
is_a: IEV:0002907 ! ATP + Nucleoside diphosphate = ADP + Nucleoside triphosphate( EC:2.7.4.6 )
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003190
name: N6,N6,N6-Trimethyl-L-lysine + 2-Oxo-glutaric acid + O2 => 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine + Succinic acid + CO2( EC:1.14.11.8 )
xref_analog: EC:1.14.11.8
xref_analog: IMR:0200119
xref_analog: IMR:0200217
xref_analog: IMR:0200324
xref_analog: IMR:0200326
xref_analog: IMR:0200480
xref_analog: IMR:0200493
xref_analog: KEGG:map00310
xref_analog: KEGG:R03451
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001457 ! Lysine degradation

[Term]
id: IEV:0003191
name: ATP + Tetrahydrofolate + L-Glutamic acid => ADP + Tetrahydrofolyl-[Glu] + Orthophosphate( EC:6.3.2.17 )
comment: ATP + L-Tetrahydro-folic acid + L-Glutamic acid => ADP + Tetrahydrofolyl-[Glu] + Orthophosphate( EC:6.3.2.17 )
xref_analog: EC:6.3.2.17
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0100119
xref_analog: IMR:0200102
xref_analog: IMR:0200157
xref_analog: IMR:0200330
xref_analog: KEGG:map00790
xref_analog: KEGG:R00942
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0003192
name: 1D-myo-Inositol 1,3,4,5-tetrakisphosphate + H2O => 1D-myo-Inositol 1,3,4-trisphosphate + Orthophosphate( EC:3.1.3.56 )
xref_analog: EC:3.1.3.56
xref_analog: IMR:0100029
xref_analog: IMR:0200102
xref_analog: IMR:0200124
xref_analog: IMR:0200357
xref_analog: KEGG:map00562
xref_analog: KEGG:map04070
xref_analog: KEGG:R03430
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0003193
name: UTP + H2O => UDP + Orthophosphate( EC:3.6.1.5 )
xref_analog: EC:3.6.1.5
xref_analog: IMR:0200102
xref_analog: IMR:0200199
xref_analog: IMR:0200206
xref_analog: IMR:0200357
xref_analog: KEGG:map00240
xref_analog: KEGG:R00159
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003194
name: ATP + D-Fructose => ADP + D-Fructose 1-phosphate( EC:2.7.1.3 )
xref_analog: EC:2.7.1.3
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200120
xref_analog: IMR:0200474
xref_analog: KEGG:map00051
xref_analog: KEGG:R00866
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001417 ! Fructose and mannose metabolism

[Term]
id: IEV:0003195
name: Pyridoxine 5'-phosphate + O2 => Pyridoxal 5'-phosphate + H2O2( EC:1.4.3.5 )
xref_analog: EC:1.4.3.5
xref_analog: IMR:0200217
xref_analog: IMR:0200229
xref_analog: IMR:0200429
xref_analog: IMR:0200487
xref_analog: KEGG:map00750
xref_analog: KEGG:R00278
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001509 ! Vitamin B6 metabolism

[Term]
id: IEV:0003196
name: NADPH + L-Kynurenine + O2 + H+ => NADP+ + 3-Hydroxy-L-kynurenine + H2O( EC:1.14.13.9 )
comment: NADPH + L-Kynurenine + O2 => NADP+ + 3-Hydroxy-L-kynurenine + H2O( EC:1.14.13.9 )
xref_analog: EC:1.14.13.9
xref_analog: IMR:0200030
xref_analog: IMR:0200066
xref_analog: IMR:0200067
xref_analog: IMR:0200217
xref_analog: IMR:0200301
xref_analog: IMR:0200357
xref_analog: IMR:0200463
xref_analog: KEGG:map00380
xref_analog: KEGG:R01960
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0003197
name: L-Tyrosine + Tetrahydrobiopterin + O2 => L-Dopa + 6,7-Dihydro-biopterin + H2O( EC:1.14.16.2 )
xref_analog: EC:1.14.16.2
xref_analog: IMR:0200045
xref_analog: IMR:0200209
xref_analog: IMR:0200217
xref_analog: IMR:0200240
xref_analog: IMR:0200290
xref_analog: IMR:0200357
xref_analog: KEGG:map00350
xref_analog: KEGG:R01815
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0003198
name: ATP + 5-Phospho-ribosyl-1-amine + Glycine => ADP + 5'-Phospho-ribosyl-glycinamide + Orthophosphate( EC:6.3.4.13 )
xref_analog: EC:6.3.4.13
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0100118
xref_analog: IMR:0200102
xref_analog: IMR:0200252
xref_analog: IMR:0200420
xref_analog: KEGG:map00230
xref_analog: KEGG:R04144
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003199
name: NAD+ + (S)-1-Pyrroline-5-carboxylic acid + 2 H2O => NADH + L-Glutamic acid + H+( EC:1.5.1.12 )
comment: NAD+ + (S)-1-Pyrroline-5-carboxylic acid + 2 H2O => NADH + L-Glutamic acid( EC:1.5.1.12 ):two-step reaction
xref_analog: EC:1.5.1.12
xref_analog: IMR:0100119
xref_analog: IMR:0200030
xref_analog: IMR:0200236
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: IMR:0200521
xref_analog: KEGG:map00250
xref_analog: KEGG:map00330
xref_analog: KEGG:R00707
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0003200
name: dTMP + H2O => Thymidine + Orthophosphate( EC:3.1.3.5 )
xref_analog: EC:3.1.3.5
xref_analog: IMR:0200102
xref_analog: IMR:0200187
xref_analog: IMR:0200357
xref_analog: IMR:0200384
xref_analog: KEGG:map00240
xref_analog: KEGG:R01569
is_a: IEV:0002751 ! 5'-ribonucleotide + H2O = ribonucleoside + phosphate( EC:3.1.3.5 )
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003201
name: N-Formyl-L-aspartic acid + H2O => L-Aspartic acid + Formic acid( EC:3.5.1.15 )
xref_analog: EC:3.5.1.15
xref_analog: IMR:0200049
xref_analog: IMR:0200110
xref_analog: IMR:0200357
xref_analog: IMR:0200459
xref_analog: KEGG:map00340
xref_analog: KEGG:map00630
xref_analog: KEGG:R00526
is_a: IEV:0002754 ! N-acyl-L-aspartate + H2O = Carboxylate + L-Aspartic acid( EC:3.5.1.15 )
relationship: part_of IEV:0001410 ! Alanine and aspartate metabolism

[Term]
id: IEV:0003202
name: ATP + 1-Phosphatidyl-1D-myo-inositol => ADP + 1-Phosphatidyl-1D-myo-inositol 3-phosphate( EC:2.7.1.137 )
xref_analog: EC:2.7.1.137
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200387
xref_analog: IMR:0200469
xref_analog: KEGG:map00562
xref_analog: KEGG:map04070
xref_analog: KEGG:R03362
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0003203
name: ATP + Pyridoxal => ADP + Pyridoxal 5'-phosphate( EC:2.7.1.35 )
xref_analog: EC:2.7.1.35
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200229
xref_analog: IMR:0200504
xref_analog: KEGG:map00750
xref_analog: KEGG:R00174
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001509 ! Vitamin B6 metabolism

[Term]
id: IEV:0003204
name: NAD+ + N-Succinyl-L-glutamate 5-semialdehyde + H2O => NADH + N-Succinyl-L-glutamic acid + H+( EC:1.2.1.71 )
comment: NAD+ + N2-Succinyl-L-glutamate 5-semialdehyde + H2O => NADH + N2-Succinyl-L-glutamic acid( EC:1.5.1.12 )
xref_analog: EC:1.2.1.71
xref_analog: IMR:0200030
xref_analog: IMR:0200222
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: IMR:0200369
xref_analog: IMR:0200521
xref_analog: KEGG:map00330
xref_analog: KEGG:R05049
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0003205
name: GTP => 3',5'-Cyclic GMP + Pyrophosphate( EC:4.6.1.1 )
xref_analog: EC:4.6.1.1
xref_analog: IMR:0001354
xref_analog: IMR:0100025
xref_analog: IMR:0200280
xref_analog: KEGG:map00230
xref_analog: KEGG:R00434
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003206
name: Sarcosine + O2 + H2O => Glycine + Formaldehyde + H2O2( EC:1.5.3.1 )
xref_analog: EC:1.5.3.1
xref_analog: IMR:0100118
xref_analog: IMR:0200017
xref_analog: IMR:0200189
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200487
xref_analog: KEGG:map00260
xref_analog: KEGG:R00610
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism

[Term]
id: IEV:0003207
name: L-O-Phospho-serine + H2O => L-Serine + Orthophosphate( EC:3.1.3.3 )
xref_analog: EC:3.1.3.3
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: IMR:0200427
xref_analog: IMR:0200453
xref_analog: KEGG:map00260
xref_analog: KEGG:R00582
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism

[Term]
id: IEV:0003208
name: NADP+ + 5-Methyl-tetrahydro-folic acid => NADPH + 5,10-Methylene-tetrahydro-folic acid + H+( EC:1.5.1.20 )
comment: NADP+ + 5-Methyl-tetrahydro-folic acid => NADPH + 5,10-Methylene-tetrahydro-folic acid( EC:1.5.1.20 )
xref_analog: EC:1.5.1.20
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200408
xref_analog: IMR:0200463
xref_analog: IMR:0200517
xref_analog: KEGG:map00670
xref_analog: KEGG:map00680
xref_analog: KEGG:R01224
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0003209
name: L-Ornithine + Carbamoyl phosphate => L-Citrulline + Orthophosphate( EC:2.1.3.3 )
xref_analog: EC:2.1.3.3
xref_analog: IMR:0200019
xref_analog: IMR:0200102
xref_analog: IMR:0200109
xref_analog: IMR:0200342
xref_analog: KEGG:map00330
xref_analog: KEGG:R01398
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0003210
name: ATP + Adenosine-5'-phospho-sulfate => ADP + 3'-Phospho-adenosine-5'-phospho-sulfate( EC:2.7.1.25 )
xref_analog: EC:2.7.1.25
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200032
xref_analog: IMR:0200079
xref_analog: KEGG:map00230
xref_analog: KEGG:map00920
xref_analog: KEGG:R00509
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003211
name: Leukotriene A4 + H2O => Leukotriene B4( EC:3.3.2.6 )
xref_analog: EC:3.3.2.6
xref_analog: IMR:0200357
xref_analog: IMR:0200376
xref_analog: IMR:0200461
xref_analog: KEGG:map00590
xref_analog: KEGG:R03057
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001449 ! Arachidonic acid metabolism

[Term]
id: IEV:0003212
name: NAD+ + IMP + H2O => NADH + XMP + H+( EC:1.1.1.205 )
comment: NAD+ + IMP + H2O => NADH + XMP( EC:1.1.1.205 )
xref_analog: EC:1.1.1.205
xref_analog: IMR:0200030
xref_analog: IMR:0200165
xref_analog: IMR:0200221
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: IMR:0200521
xref_analog: KEGG:map00230
xref_analog: KEGG:R01130
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003213
name: ATP + N-Acetyl-D-mannosamine => ADP + N-Acetyl-D-mannosamine 6-phosphate( EC:2.7.1.60 )
xref_analog: EC:2.7.1.60
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200282
xref_analog: IMR:0200518
xref_analog: KEGG:map00520
xref_analog: KEGG:R02705
is_a: IEV:0002745 ! ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate( EC:2.7.1.60 )
relationship: part_of IEV:0001421 ! Aminosugars metabolism

[Term]
id: IEV:0003214
name: 3 NADPH + 2 L-Arginine + 4 O2 + 3 H+ = 3 NADP+ + 2 L-Citrulline + 2 Nitric oxide + 4 H2O( EC:1.14.13.39 )
comment: NADPH + L-Arginine + O2 = NADP+ + L-Citrulline + NO( EC:1.14.13.39 ):multi-step reaction
xref_analog: EC:1.14.13.39
xref_analog: IMR:0100128
xref_analog: IMR:0200019
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200217
xref_analog: IMR:0200357
xref_analog: IMR:0200428
xref_analog: IMR:0200463
xref_analog: KEGG:map00330
xref_analog: KEGG:R00557
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0003215
name: 3-Methyl-butanoyl-CoA + FAD => 3-Methylbut-2-enoyl-CoA + FADH2( EC:1.3.99.10 )
comment: 3-Methyl-butanoyl-CoA + Acceptor => 3-Methylbut-2-enoyl-CoA + Reduced acceptor( EC:1.3.99.10 )
xref_analog: EC:1.3.99.10
xref_analog: IMR:0200158
xref_analog: IMR:0200298
xref_analog: KEGG:C00016
xref_analog: KEGG:C01352
xref_analog: KEGG:map00280
xref_analog: KEGG:R04095
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001454 ! Valine, leucine and isoleucine degradation

[Term]
id: IEV:0003216
name: 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate + H2O => D-myo-Inositol 1,4,5-trisphosphate + 1,2-Diacyl-sn-glycerol( EC:3.1.4.11 )
comment: 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate + H2O => D-myo-Inositol 1,4,5-trisphosphate + D-1,2-Diacyl-glycerol( EC:3.1.4.11 )
xref_analog: EC:3.1.4.11
xref_analog: IMR:0001350
xref_analog: IMR:0100028
xref_analog: IMR:0200076
xref_analog: IMR:0200357
xref_analog: KEGG:mao04070
xref_analog: KEGG:map00562
xref_analog: KEGG:R03435
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0003217
name: CoA + ATP + Propanoic acid => Propanoyl-CoA + AMP + Pyrophosphate( EC:6.2.1.1 )
comment: two-step reaction:R01354, R00926
xref_analog: EC:6.2.1.1
xref_analog: IMR:0001351
xref_analog: IMR:0200081
xref_analog: IMR:0200083
xref_analog: IMR:0200280
xref_analog: IMR:0200354
xref_analog: IMR:0200484
xref_analog: KEGG:R00925
is_a: IEV:0000394 ! CoA ligation
relationship: part_of IEV:0001426 ! Propanoate metabolism

[Term]
id: IEV:0003218
name: Protoporphyrin IX + Fe2+ = Protoheme + 2 H+( EC:4.99.1.1 )
comment: Protoporphyrin IX + Iron = Protoheme + 2 H+( EC:4.99.1.1 )
xref_analog: EC:4.99.1.1
xref_analog: IMR:0200030
xref_analog: IMR:0200089
xref_analog: IMR:0200348
xref_analog: KEGG:C14818
xref_analog: KEGG:map00860
xref_analog: KEGG:R00310
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001516 ! Porphyrin and chlorophyll metabolism

[Term]
id: IEV:0003219
name: ATP + H2O => ADP + Orthophosphate( EC:3.6.1.3 )
xref_analog: EC:3.6.1.3
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200102
xref_analog: IMR:0200357
xref_analog: KEGG:map00230
xref_analog: KEGG:R00086
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003220
name: NAD+ + H2O => Nicotinamide + ADP-ribose( EC:3.2.2.5 )
comment: NAD+ + H2O => Nicotinamide + ADP-5-ribose( EC:3.2.2.5 )
xref_analog: EC:3.2.2.5
xref_analog: IMR:0200025
xref_analog: IMR:0200134
xref_analog: IMR:0200248
xref_analog: IMR:0200357
xref_analog: KEGG:map00760
xref_analog: KEGG:R00102
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001510 ! Nicotinate and nicotinamide metabolism

[Term]
id: IEV:0003221
name: (S)-2,3-Epoxy-squalene = Lanosterol( EC:5.4.99.7 )
xref_analog: EC:5.4.99.7
xref_analog: IMR:0200096
xref_analog: IMR:0200509
xref_analog: KEGG:map00100
xref_analog: KEGG:R03199
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001443 ! Steroid biosynthesis

[Term]
id: IEV:0003222
name: NADPH + Presqualene diphosphate + H+ => NADP+ + Squalene + Pyrophosphate( EC:2.5.1.21 )
comment: NADPH + Presqualene diphosphate => NADP+ + Squalene + Pyrophosphate( EC:2.5.1.21 )
xref_analog: EC:2.5.1.21
xref_analog: IMR:0200030
xref_analog: IMR:0200067
xref_analog: IMR:0200273
xref_analog: IMR:0200280
xref_analog: IMR:0200463
xref_analog: IMR:0200481
xref_analog: KEGG:map00100
xref_analog: KEGG:R02872
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0003169 ! 2 Farnesyl diphosphate + NADPH + H+ => NADP+ + Squalene + 2 Pyrophosphate( EC:2.5.1.21 )

[Term]
id: IEV:0003223
name: N,N-Dimethyl-glycine + H2O + Acceptor => Sarcosine + Formaldehyde + Reduced acceptor( EC:1.5.99.2 )
xref_analog: EC:1.5.99.2
xref_analog: IMR:0200017
xref_analog: IMR:0200047
xref_analog: IMR:0200189
xref_analog: IMR:0200224
xref_analog: IMR:0200300
xref_analog: IMR:0200357
xref_analog: KEGG:map00260
xref_analog: KEGG:R01565
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001412 ! Glycine, serine and threonine metabolism

[Term]
id: IEV:0003224
name: AMP + H2O => IMP + NH3( EC:3.5.4.6 )
xref_analog: EC:3.5.4.6
xref_analog: IMR:0200075
xref_analog: IMR:0200083
xref_analog: IMR:0200221
xref_analog: IMR:0200357
xref_analog: KEGG:map00230
xref_analog: KEGG:R00181
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003225
name: 2 ATP + CO2 + NH3 + H2O => 2 ADP + Carbamoyl phosphate + Orthophosphate( EC:6.3.4.16 )
xref_analog: EC:6.3.4.16
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200075
xref_analog: IMR:0200102
xref_analog: IMR:0200109
xref_analog: IMR:0200324
xref_analog: IMR:0200357
xref_analog: KEGG:map00250
xref_analog: KEGG:map00330
xref_analog: KEGG:map00910
xref_analog: KEGG:R00149
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001411 ! Glutamate metabolism

[Term]
id: IEV:0003226
name: N-Methyl-histamine + H2O + O2 => Methylimidazole acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
comment: N-Methyl-histamine + H2O + O2 => 3-Methyl-imidazole acetaldehyde + NH3 + H2O2( EC:1.4.3.4 )
xref_analog: EC:1.4.3.4
xref_analog: IMR:0200075
xref_analog: IMR:0200217
xref_analog: IMR:0200325
xref_analog: IMR:0200357
xref_analog: IMR:0200401
xref_analog: IMR:0200487
xref_analog: KEGG:map00340
xref_analog: KEGG:R04674
is_a: IEV:0002734 ! Primary amine + H2O + O2 = Aldehyde + NH3 + H2O2( EC:1.4.3.4 )
relationship: part_of IEV:0001459 ! Histidine metabolism

[Term]
id: IEV:0003227
name: ATP + 1-Phosphatidyl-1D-myo-inositol 4-phosphate => ADP + 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate( EC:2.7.1.68 )
xref_analog: EC:2.7.1.68
xref_analog: IMR:0001350
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200496
xref_analog: KEGG:map00562
xref_analog: KEGG:map04070
xref_analog: KEGG:R03469
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001430 ! Inositol phosphate metabolism

[Term]
id: IEV:0003228
name: Arachidonic acid + 2 O2 => Prostaglandin G2( EC:1.14.99.1 )
comment: Arachidonic acid + 2 O2 + Reduced acceptor => Prostaglandin G2 + Acceptor( EC:1.14.99.1 ):subsequently IEV:0003091
xref_analog: EC:1.14.99.1
xref_analog: IMR:0200212
xref_analog: IMR:0200217
xref_analog: IMR:0200497
xref_analog: KEGG:map00590
xref_analog: KEGG:R01590
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0003852 ! Arachidonic acid + Reduced acceptor + 2 O2 = Prostaglandin H2 + Acceptor + H2O( EC:1.14.99.1 )

[Term]
id: IEV:0003229
name: Prostaglandin H2 => Prostaglandin D2( EC:5.3.99.2 )
xref_analog: EC:5.3.99.2
xref_analog: IMR:0200253
xref_analog: IMR:0200457
xref_analog: KEGG:map00590
xref_analog: KEGG:R02266
is_a: IEV:0000915 ! Isomerization
relationship: part_of IEV:0001449 ! Arachidonic acid metabolism

[Term]
id: IEV:0003230
name: L-Cysteine + H2O => Pyruvic acid + Hydrogen sulfide + NH3( EC:4.4.1.1 )
xref_analog: EC:4.4.1.1
xref_analog: IMR:0200075
xref_analog: IMR:0200331
xref_analog: IMR:0200357
xref_analog: IMR:0200467
xref_analog: IMR:0200514
xref_analog: KEGG:map00270
xref_analog: KEGG:R00782
is_a: IEV:0000917 ! Lyase process
relationship: part_of IEV:0001466 ! Methionine and Cysteine metabolism

[Term]
id: IEV:0003232
name: dGDP + Phosphoenol-pyruvic acid => dGTP + Pyruvic acid( EC:2.7.1.40 )
xref_analog: EC:2.7.1.40
xref_analog: IMR:0200223
xref_analog: IMR:0200286
xref_analog: IMR:0200331
xref_analog: IMR:0200365
xref_analog: KEGG:map00230
xref_analog: KEGG:R01858
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003233
name: NADPH + Prostaglandin E2 + H+ => NADP+ + Prostaglandin F2alpha( EC:1.1.1.184 )
comment: NADPH + Prostaglandin E2 => NADP+ + Prostaglandin F2alpha( EC:1.1.1.184 )
xref_analog: EC:1.1.1.184
xref_analog: IMR:0200030
xref_analog: IMR:0200051
xref_analog: IMR:0200067
xref_analog: IMR:0200146
xref_analog: IMR:0200463
xref_analog: KEGG:map00590
xref_analog: KEGG:R02581
is_a: IEV:0002723 ! Secondary alcohol + NADP+ = Ketone + NADPH + H+( EC:1.1.1.184 )
relationship: part_of IEV:0001449 ! Arachidonic acid metabolism

[Term]
id: IEV:0003234
name: ATP + UTP + NH3 => ADP + CTP + Orthophosphate( EC:6.3.4.2 )
xref_analog: EC:6.3.4.2
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200075
xref_analog: IMR:0200102
xref_analog: IMR:0200199
xref_analog: IMR:0200202
xref_analog: KEGG:map00240
xref_analog: KEGG:R00571
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003235
name: dUTP + H2O => dUMP + Pyrophosphate( EC:3.6.1.23 )
xref_analog: EC:3.6.1.23
xref_analog: IMR:0200008
xref_analog: IMR:0200056
xref_analog: IMR:0200280
xref_analog: IMR:0200357
xref_analog: KEGG:map00240
xref_analog: KEGG:R02100
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003236
name: L-Tryptophan + O2 => N-Formyl-L-kynurenine( EC:1.13.11.11 )
xref_analog: EC:1.13.11.11
xref_analog: IMR:0200038
xref_analog: IMR:0200217
xref_analog: IMR:0200307
xref_analog: KEGG:map00380
xref_analog: KEGG:R00678
is_a: IEV:0000914 ! Oxidation/Reduction
relationship: part_of IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0003237
name: ATP + L-Aspartic acid + L-Citrulline => AMP + Pyrophosphate + L-Arginino-succinic acid( EC:6.3.4.5 )
xref_analog: EC:6.3.4.5
xref_analog: IMR:0001351
xref_analog: IMR:0200019
xref_analog: IMR:0200083
xref_analog: IMR:0200280
xref_analog: IMR:0200391
xref_analog: IMR:0200459
xref_analog: KEGG:map00250
xref_analog: KEGG:map00330
xref_analog: KEGG:R01954
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001410 ! Alanine and aspartate metabolism
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0003238
name: dGTP + H2O => dGMP + Pyrophosphate( EC:3.6.1.19 )
xref_analog: EC:3.6.1.19
xref_analog: IMR:0200280
xref_analog: IMR:0200286
xref_analog: IMR:0200357
xref_analog: IMR:0200505
xref_analog: KEGG:map00230
xref_analog: KEGG:R01855
is_a: IEV:0002755 ! Nucleoside triphosphate + H2O = Nucleotide + diphosphate( EC:3.6.1.19 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003239
name: dITP + H2O => dIMP + Pyrophosphate( EC:3.6.1.19 )
xref_analog: EC:3.6.1.19
xref_analog: IMR:0200122
xref_analog: IMR:0200280
xref_analog: IMR:0200357
xref_analog: IMR:0200446
xref_analog: KEGG:map00230
xref_analog: KEGG:R03531
is_a: IEV:0002755 ! Nucleoside triphosphate + H2O = Nucleotide + diphosphate( EC:3.6.1.19 )
relationship: part_of IEV:0001450 ! Purine metabolism

[Term]
id: IEV:0003240
name: ATP + Tetrahydrofolate + Formic acid => ADP + 10-Formyl-tetrahydro-folic acid + Orthophosphate( EC:6.3.4.3 )
comment: ATP + L-Tetrahydro-folic acid + Formic acid => ADP + 10-Formyl-tetrahydro-folic acid + Orthophosphate( EC:6.3.4.3 )
xref_analog: EC:6.3.4.3
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200102
xref_analog: IMR:0200110
xref_analog: IMR:0200330
xref_analog: IMR:0200347
xref_analog: KEGG:map00630
xref_analog: KEGG:map00670
xref_analog: KEGG:R00943
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0003241
name: dTDP + H2O => dTMP + Orthophosphate( EC:3.6.1.5 )
xref_analog: EC:3.6.1.5
xref_analog: IMR:0200102
xref_analog: IMR:0200187
xref_analog: IMR:0200338
xref_analog: IMR:0200357
xref_analog: KEGG:map00240
xref_analog: KEGG:R02092
is_a: IEV:0000184 ! Hydrolysis
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003242
name: ATP + 7,8-Dihydro-pteroic acid + L-Glutamic acid => ADP + 7,8-Dihydro-folic acid + Orthophosphate( EC:6.3.2.17 )
xref_analog: EC:6.3.2.17
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0100119
xref_analog: IMR:0200102
xref_analog: IMR:0200176
xref_analog: IMR:0200185
xref_analog: KEGG:map00790
xref_analog: KEGG:R02237
is_a: IEV:0000912 ! Ligation
relationship: part_of IEV:0001514 ! Folate metabolism

[Term]
id: IEV:0003243
name: S-Adenosylmethioninamine + Putrescine => 5'-Methylthio-adenosine + Spermidine( EC:2.5.1.16 )
comment: S-Adenosyl-L-methioninamine + Putrescine => 5'-Methylthio-adenosine + Spermidine( EC:2.5.1.16 )
xref_analog: EC:2.5.1.16
xref_analog: IMR:0200028
xref_analog: IMR:0200153
xref_analog: IMR:0200175
xref_analog: IMR:0200285
xref_analog: KEGG:map00270
xref_analog: KEGG:map00330
xref_analog: KEGG:map00480
xref_analog: KEGG:R01920
is_a: IEV:0000913 ! Transference
relationship: part_of IEV:0001458 ! Arginine and proline metabolism

[Term]
id: IEV:0003244
name: ATP + Pyridoxamine => ADP + Pyridoxamine 5'-phosphate( EC:2.7.1.35 )
xref_analog: EC:2.7.1.35
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200309
xref_analog: IMR:0200382
xref_analog: KEGG:map00750
xref_analog: KEGG:R02493
is_a: IEV:0000005 ! Phosphorylation
relationship: part_of IEV:0001509 ! Vitamin B6 metabolism

[Term]
id: IEV:0003245
name: ATP + D-Mannose => ADP + D-Mannose 6-phosphate( EC:2.7.1.1 )
xref_analog: EC:2.7.1.1
xref_analog: IMR:0001351
xref_analog: IMR:0001360
xref_analog: IMR:0200053
xref_analog: IMR:0200230
xref_analog: KEGG:map00051
xref_analog: KEGG:map00520
xref_analog: KEGG:R01326
is_a: IEV:0002744 ! ATP + D-hexose = ADP + D-hexose 6-phosphate( EC:2.7.1.1 )
relationship: part_of IEV:0001417 ! Fructose and mannose metabolism

[Term]
id: IEV:0003246
name: Pyridoxal + O2 + H2O => 4-Pyridoxic acid + H2O2( EC:1.2.3.1 )
xref_analog: EC:1.2.3.1
xref_analog: IMR:0200217
xref_analog: IMR:0200267
xref_analog: IMR:0200357
xref_analog: IMR:0200487
xref_analog: IMR:0200504
xref_analog: KEGG:map00750
xref_analog: KEGG:R01709
is_a: IEV:0002731 ! Aldehyde + H2O + O2 = Carboxylate + H2O2( EC:1.2.3.1 )
relationship: part_of IEV:0001509 ! Vitamin B6 metabolism

[Term]
id: IEV:0003247
name: UDP + Reduced thioredoxin => dUDP + H2O + Oxidized thioredoxin( EC:1.17.4.1 )
xref_analog: EC:1.17.4.1
xref_analog: IMR:0200098
xref_analog: IMR:0200108
xref_analog: IMR:0200133
xref_analog: IMR:0200206
xref_analog: IMR:0200357
xref_analog: KEGG:map00240
xref_analog: KEGG:R02018
is_a: IEV:0002728 ! 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin( EC:1.17.4.1 )
relationship: part_of IEV:0001451 ! Pyrimidine metabolism

[Term]
id: IEV:0003248
name: NADP+ + beta-D-Glucose 6-phosphate => NADPH + D-Glucono-1,5-lactone 6-phosphate + H+( EC:1.1.1.49 )
comment: NADP+ + D-Glucose 6-phosphate => NADPH + D-6-Phospho-glucono 1,5-lactone( EC:1.1.1.49 )
xref_analog: EC:1.1.1.49
xref_