format-version: 1.0
date: 03:10:2007 16:20
saved-by: sakainoriko
auto-generated-by: OBO-Edit 1.002
default-namespace: event
remark: version: 1.62

[Term]
id: IEV:0000000
name: Event

[Term]
id: IEV:0000001
name: Pathway
is_a: IEV:0000071 ! Molecular event

[Term]
id: IEV:0000002
name: Cell differentiation
def: "The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GO:0030154]
xref_analog: GO:0030154
is_a: IEV:0000069 ! Cellular event
relationship: part_of IEV:0000083 ! Development

[Term]
id: IEV:0000003
name: Biological event
is_a: IEV:0000000 ! Event

[Term]
id: IEV:0000004
name: Binding
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000005
name: Phosphorylation
def: "Reversible reaction that can affect D,C,H,S,T,Y,R residues." [MI:0217]
xref_analog: EC:2.7
xref_analog: GO:0016310
xref_analog: MI:0217
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0000006
name: Dissociation
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000007
name: Unknown inactivation
is_a: IEV:0000220 ! Unknown process

[Term]
id: IEV:0000008
name: Unknown activation
is_a: IEV:0000220 ! Unknown process

[Term]
id: IEV:0000009
name: Translocation
def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells." [GO:0006810]
related_synonym: "transport" []
xref_analog: GO:0006810
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000010
name: Proteasome degradation
def: "Cleavage of peptide bonds with very broad specificity" [EC:3.4.25.1]
xref_analog: EC:3.4.25.1
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0000011
name: Dephosphorylation
def: "Phosphoresidues are cleaved and return D,C,H,S,T,Y or R residues." [MI:0203]
xref_analog: MI:0203
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0000012
name: Ubiquitination
def: "Reversible reaction that create a covalent bond between a C-terminus G of ubiquitin and a K residue of the target." [MI:0220]
xref_analog: EC:6.3.2.19
xref_analog: MI:0220
is_a: IEV:0000912 ! Ligation

[Term]
id: IEV:0000013
name: Binding in cytosol
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0000014
name: Binding in plasma membrane
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0000015
name: Binding in nucleus
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0000016
name: Binding in extracellular
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0000017
name: Binding in nuclear membrane
is_a: IEV:0000015 ! Binding in nucleus

[Term]
id: IEV:0000018
name: Nuclear import
def: "The directed movement of substances into the nucleus." [GO:0051170]
related_synonym: "import into nucleus" []
related_synonym: "nucleus import" []
related_synonym: "substance nuclear import" []
xref_analog: GO:0051170
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000019
name: Nuclear export
def: "The directed movement of substances out of the nucleus." [GO:0051168]
related_synonym: "export from nucleus" []
related_synonym: "nucleus export" []
related_synonym: "substance nuclear export" []
xref_analog: GO:0051168
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000020
name: Activation in cytosol
is_a: IEV:0000008 ! Unknown activation

[Term]
id: IEV:0000021
name: Proteasome degradation in cytosol
is_a: IEV:0000010 ! Proteasome degradation

[Term]
id: IEV:0000022
name: Dephosphorylation in cytosol
is_a: IEV:0000011 ! Dephosphorylation

[Term]
id: IEV:0000023
name: Dissociation in cytosol
is_a: IEV:0000006 ! Dissociation

[Term]
id: IEV:0000024
name: Inactivation in cytosol
is_a: IEV:0000007 ! Unknown inactivation

[Term]
id: IEV:0000025
name: Phosphorylation in cytosol
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0000026
name: Ubiquitination in cytosol
is_a: IEV:0000012 ! Ubiquitination

[Term]
id: IEV:0000027
name: Wnt signaling pathway
def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell." [GO:0016055]
related_synonym: "Wnt receptor signaling pathway" [GO:0016055]
xref_analog: GO:0016055
xref_analog: KEGG:hsa04310
xref_analog: PubMed:15473860
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000091 ! Cell growth
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0002536 ! Mesodermal cell fate determination
relationship: part_of IEV:0002541 ! Endodermal cell fate determination

[Term]
id: IEV:0000028
name: Chemical treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0000029
name: Binding of Frizzled and DSH
xref_analog: PubMed:14636582
xref_analog: PubMed:15473860
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0002267 ! Wnt signaling pathway (Xenopus)
relationship: part_of IEV:0002268 ! Wnt signaling pathway (Mammalia)
relationship: part_of IEV:0002269 ! Wnt signaling pathway (Drosophila)

[Term]
id: IEV:0000030
name: Phosphorylation of DSH by CK
xref_analog: PubMed:10517632
xref_analog: PubMed:10656974
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0002267 ! Wnt signaling pathway (Xenopus)
relationship: part_of IEV:0002268 ! Wnt signaling pathway (Mammalia)

[Term]
id: IEV:0000031
name: Inactivation of GSK3beta by DSH_p
is_a: IEV:0000024 ! Inactivation in cytosol
is_a: IEV:0001744 ! GSK3beta inactivation signaling
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0000032
name: Complex formation of Axin, APC, GKS3beta, CK1alpha and beta catenin
xref_analog: PubMed:15549094
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0000033
name: Binding in the mitochondria membrane
is_a: IEV:0001036 ! Binding in mitochondria

[Term]
id: IEV:0000034
name: Nuclear import of beta catenin
xref_analog: PubMed:15473860
xref_analog: PubMed:15549094
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0002267 ! Wnt signaling pathway (Xenopus)
relationship: part_of IEV:0002268 ! Wnt signaling pathway (Mammalia)
relationship: part_of IEV:0002269 ! Wnt signaling pathway (Drosophila)

[Term]
id: IEV:0000035
name: Binding of beta-catenin and TCF
xref_analog: PubMed:12210516
xref_analog: PubMed:15473860
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001819 ! Complex formation of beta catenin, TCF/LEF, Legs, Pygonus, etc.
relationship: part_of IEV:0002267 ! Wnt signaling pathway (Xenopus)
relationship: part_of IEV:0002268 ! Wnt signaling pathway (Mammalia)
relationship: part_of IEV:0002269 ! Wnt signaling pathway (Drosophila)
relationship: part_of IEV:0002270 ! C. elegans endoderm induction Wnt signaling pathway

[Term]
id: IEV:0000036
name: Binding of TCF/LEF and responsive element
xref_analog: PubMed:14755243
xref_analog: PubMed:15292219
xref_analog: PubMed:15473860
xref_analog: PubMed:15549094
is_a: IEV:0002098 ! Binding of transcriptional factor and responsive element
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0002267 ! Wnt signaling pathway (Xenopus)
relationship: part_of IEV:0002268 ! Wnt signaling pathway (Mammalia)
relationship: part_of IEV:0002269 ! Wnt signaling pathway (Drosophila)

[Term]
id: IEV:0000038
name: Activation in unidentified cellular location
is_a: IEV:0000008 ! Unknown activation

[Term]
id: IEV:0000039
name: Proteasome degradation in unidentified cellular location
is_a: IEV:0000010 ! Proteasome degradation

[Term]
id: IEV:0000040
name: Dephosphorylation in unidentified cellular location
is_a: IEV:0000011 ! Dephosphorylation

[Term]
id: IEV:0000041
name: Dissociation of Axin, APC, GKS3beta, CK1alpha and beta-catenin
xref_analog: PubMed:15473860
xref_analog: PubMed:15549094
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0002267 ! Wnt signaling pathway (Xenopus)
relationship: part_of IEV:0002268 ! Wnt signaling pathway (Mammalia)
relationship: part_of IEV:0002269 ! Wnt signaling pathway (Drosophila)

[Term]
id: IEV:0000042
name: Binding of Wnt and Frizzled
xref_analog: PubMed:15473860
xref_analog: PubMed:15549094
xref_analog: PubMed:9288750
is_a: IEV:0001816 ! Binding of Wnt and Wnt receptor
relationship: part_of IEV:0002270 ! C. elegans endoderm induction Wnt signaling pathway

[Term]
id: IEV:0000043
name: Inorganic chemical treatment
is_a: IEV:0000028 ! Chemical treatment

[Term]
id: IEV:0000044
name: JAK STAT pathway
alt_id: IEV:0000137
def: "The processes by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes." [GO:0007259]
xref_analog: GO:0007259
xref_analog: KEGG:hsa04630
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000077 ! Cell cycle
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000099 ! Tumorigenesis
relationship: part_of IEV:0000448 ! Hematopoiesis

[Term]
id: IEV:0000045
name: Binding of cytokine and cytokine receptors and conformational change of receptors
xref_analog: PubMed:9974393
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000046
name: Binding of cytokine receptor and STAT
xref_analog: PubMed:15541651
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000047
name: Dimerization of STAT
def: "The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GO:0007261]
related_synonym: "JAK-induced STAT protein dimerization" []
related_synonym: "STAT dimerization" []
xref_analog: GO:0007261
xref_analog: PubMed:12039028
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000048
name: Nuclear import of STAT dimer
def: "The transport of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GO:0007262]
related_synonym: "STAT protein nuclear translocation" []
xref_analog: GO:0007262
xref_analog: PubMed:12039028
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000049
name: Binding of STAT dimer and responsive element
xref_analog: PubMed:12039028
is_a: IEV:0002098 ! Binding of transcriptional factor and responsive element
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000050
name: Transcription by STAT dimer
xref_analog: PubMed:12039028
xref_analog: PubMed:14607831
is_a: IEV:0000183 ! Transcription
relationship: part_of IEV:0002102 ! Gene expression by STAT dimer

[Term]
id: IEV:0000051
name: Binding of cytokine receptor and JAK
xref_analog: PubMed:12039028
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000052
name: Autophosphorylation of Jak
def: "The process of introducing a phosphoric group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GO:0042976]
related_synonym: "activation of JAK protein" []
related_synonym: "positive regulation of JAK protein activity by tyrosine phosphorylation" []
xref_analog: GO:0042976
xref_analog: PubMed:9974393
is_a: IEV:0000481 ! Autophosphorylation in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000053
name: Phosphorylation of cytokine receptor by Jak
xref_analog: PubMed:15541651
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000054
name: Bad inactivation signaling
related_synonym: "Bad inactivation signaling" []
related_synonym: "Bad phosphorylation signaling" []
is_a: IEV:0001030 ! Apoptotic factor inactivation signaling
is_a: IEV:0001800 ! Negative regulation of Bad activation signaling
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000055
name: PKA-Bad signaling
is_a: IEV:0000054 ! Bad inactivation signaling

[Term]
id: IEV:0000056
name: RSK-Bad signaling
is_a: IEV:0000054 ! Bad inactivation signaling
relationship: part_of IEV:0000126 ! Insulin receptor signaling pathway (through ERK cascade)
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000057
name: Activation of mTOR by AKT
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000112 ! AKT(PKB)-mTOR signaling

[Term]
id: IEV:0000059
name: TGF beta super family signaling pathway (through p38 cascade)
is_a: IEV:0000090 ! TGF beta super family signaling pathway
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0000060
name: Grb2-Sos-Ras-PI3K signaling
is_a: IEV:0001258 ! Ras mediated signaling
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000061
name: Phosphorylation of 4EBP by mTOR
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000112 ! AKT(PKB)-mTOR signaling

[Term]
id: IEV:0000062
name: JNK signaling (Angiotensin induced)
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000063
name: IL1 signaling (through IKK-NF-kappaB cascade)
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000110 ! IL1 signaling pathway
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000064
name: Organic chemical treatment
is_a: IEV:0000028 ! Chemical treatment

[Term]
id: IEV:0000065
name: PLC beta signaling
is_a: IEV:0000471 ! PLC signaling
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
relationship: part_of IEV:0000773 ! Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o and PLCbeta)
relationship: part_of IEV:0002633 ! Heterotrimeric GPCR signaling pathway (through Angiotensin and G alpha q)
relationship: part_of IEV:0002653 ! Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)

[Term]
id: IEV:0000066
name: CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000460 ! T cell receptor signaling pathway

[Term]
id: IEV:0000067
name: Activation of p70S6K by mTOR
relationship: part_of IEV:0000112 ! AKT(PKB)-mTOR signaling

[Term]
id: IEV:0000068
name: Translocation of Notch (NIC) from plasma membrane to cytosol
xref_analog: PubMed:14985712
is_a: IEV:0000508 ! Translocation from plasma membrane to cytosol
relationship: part_of IEV:0001171 ! Nuclear import of Notch (NIC) from the plasma membrane

[Term]
id: IEV:0000069
name: Cellular event
alt_id: IEV:0001318
def: "Processes that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GO:0009987]
related_synonym: "Cellular physiological event" []
related_synonym: "Cellular physiological process" [GO:0050875]
xref_analog: GO:0009987
xref_analog: GO:0050875
is_a: IEV:0000003 ! Biological event

[Term]
id: IEV:0000070
name: Apoptosis (Inhibition of cell survival)
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposition of phosphatidylserine." [GO:0006915]
xref_analog: GO:0006915
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000101 ! Programmed cell death

[Term]
id: IEV:0000071
name: Molecular event
is_a: IEV:0000003 ! Biological event

[Term]
id: IEV:0000072
name: Dormancy
def: "The process by which a dormant state is induced, maintained and broken. Dormancy is characterized by a suspension of physiological activity." [GO:0022611]
xref_analog: GO:0022611
is_a: IEV:0001330 ! Physiological event

[Term]
id: IEV:0000073
name: Bud dormancy
is_a: IEV:0000072 ! Dormancy

[Term]
id: IEV:0000074
name: Seed dormancy
def: "The process by which a dormant state is induced and maintained in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated once dormancy is broken." [GO:0010162]
xref_analog: GO:0010162
is_a: IEV:0000072 ! Dormancy
relationship: part_of IEV:0001329 ! Seed development

[Term]
id: IEV:0000075
name: Disease
is_a: IEV:0000082 ! Organism event

[Term]
id: IEV:0000076
name: Cell proliferation
def: "The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population." [GO:0008283]
xref_analog: GO:0008283
is_a: IEV:0001317 ! Cell growth and/or maintenance

[Term]
id: IEV:0000077
name: Cell cycle
def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GO:0007049]
xref_analog: GO:0007049
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0000078
name: Cell cycle arrest
relationship: part_of IEV:0000077 ! Cell cycle

[Term]
id: IEV:0000079
name: Cytokinesis
def: "The processes resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components." [GO:0000910]
xref_analog: GO:0000910
is_a: IEV:0003382 ! Cell division
relationship: part_of IEV:0000102 ! M phase

[Term]
id: IEV:0000080
name: Transdifferentiation
is_a: IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0000081
name: Epithelial to mesenchymal transdifferentiation
is_a: IEV:0000080 ! Transdifferentiation

[Term]
id: IEV:0000082
name: Organism event
is_a: IEV:0000003 ! Biological event

[Term]
id: IEV:0000083
name: Development
def: "Biological processes specifically aimed at the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GO:0007275]
related_synonym: "multicellular organismal development" [GO:0007275]
xref_analog: GO:0007275
is_a: IEV:0000082 ! Organism event

[Term]
id: IEV:0000084
name: Adipocyte differentiation
def: "The process whereby a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [GO:0045444]
related_synonym: "adipocyte cell differentiation" [GO:0045444]
related_synonym: "adipose cell differentiation" [GO:0045444]
related_synonym: "fat cell differentiation" [GO:0045444]
xref_analog: GO:0045444
is_a: IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0000085
name: Myoblast differentiation
def: "The process whereby a relatively unspecialized cell acquires specialized features of a myoblast, a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 	\n  " [GO:0045445]
xref_analog: GO:0045445
is_a: IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0000086
name: Osteoblast differentiation
def: "Differentiation of the osteoblast; which is the mesodermal cell that gives rise to bone." [GO:0001649]
xref_analog: GO:0001649
is_a: IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0000087
name: Inhibition of Adipocyte differentiation
def: "Any process that stops, prevents or reduces the rate, frequency or extent of adipocyte differentiation." [GO:0045599]
related_synonym: "negative regulation of fat cell differentiation" [GO:0045599]
xref_analog: GO:0045599
is_a: IEV:0000084 ! Adipocyte differentiation

[Term]
id: IEV:0000088
name: Negative regulation of of myoblast differentiation
def: "Any process that stops, prevents or reduces the rate, frequency or extent of myoblast differentiation." [GO:0045662]
xref_analog: GO:0045662
is_a: IEV:0000085 ! Myoblast differentiation

[Term]
id: IEV:0000089
name: Negative regulation of osteoblast differentiation
def: "Any process that stops, prevents or reduces the rate, frequency or extent of osteoblast differentiation." [GO:0045668]
xref_analog: GO:0045668
is_a: IEV:0000086 ! Osteoblast differentiation

[Term]
id: IEV:0000090
name: TGF beta super family signaling pathway
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000081 ! Epithelial to mesenchymal transdifferentiation
relationship: part_of IEV:0000091 ! Cell growth
relationship: part_of IEV:0000092 ! Cytoskeleton organization and biogenesis
relationship: part_of IEV:0000093 ! Lamellipodium biogenesis
relationship: part_of IEV:0000094 ! Membrane ruffling
relationship: part_of IEV:0000095 ! Stress fiber formation
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000099 ! Tumorigenesis
relationship: part_of IEV:0000578 ! Tissue regeneration

[Term]
id: IEV:0000091
name: Cell growth
def: "The process by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GO:0016049]
xref_analog: GO:0016049
is_a: IEV:0001317 ! Cell growth and/or maintenance

[Term]
id: IEV:0000092
name: Cytoskeleton organization and biogenesis
def: "The assembly and arrangement of cytoskeletal structures." [GO:0007010]
xref_analog: GO:0007010
is_a: IEV:0001322 ! Organelle organization and biogenesis

[Term]
id: IEV:0000093
name: Lamellipodium biogenesis
def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GO:0030032]
xref_analog: GO:0030032
is_a: IEV:0001325 ! Cellular morphogenesis

[Term]
id: IEV:0000094
name: Membrane ruffling
is_a: IEV:0001325 ! Cellular morphogenesis

[Term]
id: IEV:0000095
name: Stress fiber formation
def: "Assembly of a stress fiber, the bundle of microfilaments and other proteins found in fibroblasts." [GO:0043149]
xref_analog: GO:0043149
is_a: IEV:0001324 ! Actin filament organization

[Term]
id: IEV:0000096
name: Ecodormancy
relationship: part_of IEV:0000073 ! Bud dormancy

[Term]
id: IEV:0000097
name: Cell death
def: "The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GO:0008219]
xref_analog: GO:0008219
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0000098
name: Immune response
def: "Any process involved in the immunological reaction of an organism to an immunogenic stimulus." [GO:0006955]
xref_analog: GO:0006955
is_a: IEV:0001332 ! Response to stimulus

[Term]
id: IEV:0000099
name: Tumorigenesis
related_synonym: "oncogenesis" [GO:0007048]
xref_analog: GO:0007048
is_a: IEV:0000082 ! Organism event

[Term]
id: IEV:0000101
name: Programmed cell death
def: "Cell death resulting from activation of endogenous cellular processes." [GO:0012501]
xref_analog: GO:0012501
is_a: IEV:0000097 ! Cell death

[Term]
id: IEV:0000102
name: M phase
def: "Progression through M phase, the part of the cell cycle comprising nuclear division and cytokinesis." [GO:0000279]
xref_analog: GO:0000279
relationship: part_of IEV:0000077 ! Cell cycle

[Term]
id: IEV:0000103
name: Cell motility
def: "Any process involved in the controlled movement of a cell." [GO:0006928]
xref_analog: GO:0006928
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0000104
name: Cell migration
def: "The orderly movement of cells from one site to another, often during the development of a multicellular organism." [GO:0016477]
xref_analog: GO:0016477
is_a: IEV:0000103 ! Cell motility

[Term]
id: IEV:0000105
name: Cell adhesion
def: "The attachment of a cell, either to another cell or to the extracellular matrix, via cell adhesion molecules." [GO:0007155]
xref_analog: GO:0007155
xref_analog: KEGG:hsa04510
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0000106
name: Behavior
def: "The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GO:0007610]
xref_analog: GO:0007610
is_a: IEV:0000082 ! Organism event
is_a: IEV:0001332 ! Response to stimulus

[Term]
id: IEV:0000107
name: B cell receptor signaling pathway
def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell." [GO:0050853]
related_synonym: "B lymphocyte receptor signaling pathway" [GO:0050853]
related_synonym: "B-cell receptor signaling pathway" [GO:0050853]
related_synonym: "B-lymphocyte receptor signaling pathway" [GO:0050853]
xref_analog: GO:0050853
xref_analog: KEGG:hsa04662
xref_analog: PubMed:14632637
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000098 ! Immune response

[Term]
id: IEV:0000108
name: Toll-like receptor signaling pathway (p38 cascade)
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000462 ! Toll-like receptor signaling pathway

[Term]
id: IEV:0000109
name: Negative regulation of BAD inactivation signaling
related_synonym: "Negative regulation of BAD phosphorylation signaling" []
is_obsolete: true

[Term]
id: IEV:0000110
name: IL1 signaling pathway
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000111
name: Skeletal muscle hypertrophy
is_a: IEV:0000576 ! Organ morphogenesis

[Term]
id: IEV:0000112
name: AKT(PKB)-mTOR signaling
xref_analog: KEGG:hsa04150
is_a: IEV:0001699 ! AKT signaling
relationship: part_of IEV:0000111 ! Skeletal muscle hypertrophy

[Term]
id: IEV:0000113
name: TNFR1 signaling pathway (through NF-kappaB cascade)
alt_id: IEV:0000119
related_synonym: "TNFR2 Signaling Pathway" []
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0002408 ! TNFR1 signaling pathway

[Term]
id: IEV:0000114
name: TNFR1 signaling pathway (through caspase cascade)
related_synonym: "TNF signaling" []
xref_analog: GO:0008624
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0002408 ! TNFR1 signaling pathway

[Term]
id: IEV:0000115
name: ERK cascade
xref_analog: PubMed:14734786
is_a: IEV:0000445 ! MAPKKK cascade
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000091 ! Cell growth
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000126 ! Insulin receptor signaling pathway (through ERK cascade)
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000865 ! EGF signaling pathway
relationship: part_of IEV:0000866 ! NGF signaling pathway
relationship: part_of IEV:0001234 ! TPO signaling pathway (through Sos, Ras and Erk cascade)
relationship: part_of IEV:0001257 ! PDGF signaling pathway
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0002626 ! FGF signaling pathway
relationship: part_of IEV:0002627 ! HGF signaling pathway
relationship: part_of IEV:0002632 ! VEGF signaling pathway
relationship: part_of IEV:0002653 ! Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)
relationship: part_of IEV:0003328 ! FGF8 signaling pathway(Xenopus)
relationship: part_of IEV:0003329 ! FGF8 signaling pathway(Mouse)

[Term]
id: IEV:0000116
name: Negative feedback regulation of Ras-Raf-MAPK signaling by Sprouty (Drosophila)
is_a: IEV:0000449 ! Negative regulation of Ras-Raf-MAPK signaling by spred (Drosophila)

[Term]
id: IEV:0000117
name: Negative feedback regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
is_a: IEV:0000449 ! Negative regulation of Ras-Raf-MAPK signaling by spred (Drosophila)

[Term]
id: IEV:0000118
name: SUMOylation
def: "Reversible reaction that create a covalent bond between a C-terminus G of an ubiquitine like  sumo protein and a K residue of the target." [MI:0566]
xref_analog: MI:0566
is_a: IEV:0000912 ! Ligation

[Term]
id: IEV:0000120
name: TPO signaling pathway
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000122
name: Proteasome mediated protein degradation signaling
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GO:0043161]
related_synonym: "proteasomal pathway" []
related_synonym: "proteasomal ubiquitin-dependent protein breakdown" []
related_synonym: "proteasomal ubiquitin-dependent protein catabolic process" []
related_synonym: "proteasomal ubiquitin-dependent protein catabolism" []
related_synonym: "proteasomal ubiquitin-dependent protein degradation" []
xref_analog: GO:0043161
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000123
name: PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0001257 ! PDGF signaling pathway

[Term]
id: IEV:0000124
name: Integrin signaling pathway
def: "Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands." [GO:0007229]
xref_analog: GO:0007229
xref_analog: KEGG:hsa04510
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0002534 ! Filopodium formation

[Term]
id: IEV:0000125
name: Glutamate receptor signaling pathway
def: "The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor. " [GO:0007215]
related_synonym: "glutamate signaling pathway" []
xref_analog: GO:0007215
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000126
name: Insulin receptor signaling pathway (through ERK cascade)
is_a: IEV:0000487 ! Insulin receptor signaling pathway
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000127
name: Integrin signaling pathway (through ERK cascade)
xref_analog: KEGG:hsa04510
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000092 ! Cytoskeleton organization and biogenesis
relationship: part_of IEV:0000095 ! Stress fiber formation
relationship: part_of IEV:0000104 ! Cell migration
relationship: part_of IEV:0000124 ! Integrin signaling pathway
relationship: part_of IEV:0000397 ! Embryonic development

[Term]
id: IEV:0000128
name: Caspase Cascade
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0000129
name: Oligomerization of Bax
related_synonym: "Oligomerization of BAX at the mitochondrial membrane" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000167 ! Bax activation signaling

[Term]
id: IEV:0000130
name: Cyclin E degradation signaling
xref_analog: GO:0008054
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
is_a: IEV:0000391 ! Negative regulation of G1-S-phase transition pathway

[Term]
id: IEV:0000131
name: Phosphorylation of Bad by RSK
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000056 ! RSK-Bad signaling

[Term]
id: IEV:0000132
name: Binding of CIS and JAK
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000143 ! Negative feedback regulation of JAK STAT pathway by  (binding of CIS and JAK)

[Term]
id: IEV:0000133
name: Growth hormone signaling pathway (JAK2, STAT5)
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000134
name: IL4 signaling pathway (JAK1, JAK3, STAT6)
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000135
name: IL3 signaling pathway (JAK1, JAK2, STAT5)
is_a: IEV:0000044 ! JAK STAT pathway
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000136
name: IL2 signaling (JAK1, JAK3, STAT5)
xref_analog: PubMed:8700888
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000138
name: IL12 signaling pathway (JAK2, TYK2, STAT4)
xref_analog: PubMed:10415122
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000139
name: IL10 signaling (JAK1, TYK2, STAT3)
xref_analog: PubMed:10433356
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000140
name: IL7 signaling (JAK1, JAK3, STAT5)
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000141
name: Flower development
def: "The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem." [GO:0009908]
related_synonym: "Flowering" []
xref_analog: GO:0009908
is_a: IEV:0000083 ! Development
is_a: IEV:0000575 ! Post-embryonic morphogenesis

[Term]
id: IEV:0000142
name: Growth
def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GO:0040007]
xref_analog: GO:0040007
is_a: IEV:0000083 ! Development

[Term]
id: IEV:0000143
name: Negative feedback regulation of JAK STAT pathway by  (binding of CIS and JAK)
is_a: IEV:0002228 ! Negative feedback regulation of JAK STAT pathway

[Term]
id: IEV:0000145
name: Regulation pathway
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000146
name: Dephosphorylation of Jak by PTP
relationship: part_of IEV:0001844 ! Negative regulation of (Phosphorylation of JAK) in JAK STAT pathway

[Term]
id: IEV:0000147
name: Dephosphorylation of cytokine receptor by PTP
relationship: part_of IEV:0001843 ! Negative regulation of (Phosphorylation of cytokine receptor) in JAK STAT pathway

[Term]
id: IEV:0000148
name: Negative regulation of translation by PIAS
xref_analog: PubMed:15021887
is_a: IEV:0001838 ! Negative regulation of transcription

[Term]
id: IEV:0000149
name: Dephosphorylation of STAT dimer by PTP
relationship: part_of IEV:0001845 ! Negative regulation of (Phosphorylation of STAT) in JAK STAT pathway
relationship: part_of IEV:0002245 ! Negative regulation of (Dimerization of STAT) in JAK STAT pathway

[Term]
id: IEV:0000150
name: Negative regulation of JAK STAT pathway
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GO:0046426]
xref_analog: GO:0046426
is_a: IEV:0000550 ! Regulation of JAK STAT pathway
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000151
name: Negative feedback regulation of JAK STAT pathway by (binding of CIS and cytokine receptor)
is_a: IEV:0002228 ! Negative feedback regulation of JAK STAT pathway

[Term]
id: IEV:0000152
name: Binding of CIS and Cytokine receptor
relationship: part_of IEV:0000151 ! Negative feedback regulation of JAK STAT pathway by (binding of CIS and cytokine receptor)

[Term]
id: IEV:0000153
name: Cell survival (Inhibition of apoptosis)
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0000154
name: Binding of TGF beta and TGF beta superfamily receptor
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000155
name: Transcription by R-smad:smad4
is_a: IEV:0001145 ! Transcription by Smad complex
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000156
name: Binding of R-smad:smad4 complex Coactivator and responsive element
is_a: IEV:0002098 ! Binding of transcriptional factor and responsive element
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000157
name: Phosphorylation of R-smad by TGF beta receptor I
xref_analog: GO:0007182
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000158
name: Nuclear import of R-smad:smad4
xref_analog: GO:0007184
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000159
name: Complex formation of R-smad and Smad4
xref_analog: GO:0007183
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000160
name: Phosphorylation of TGF-b receptor I by TGF beta receptor II
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway
relationship: part_of IEV:0002339 ! TGF beta signaling pathway (through TAK1)

[Term]
id: IEV:0000161
name: Fas signaling pathway (through caspase cascade)
related_synonym: "FasL/ CD95L signaling" []
xref_analog: GO:0008624
is_a: IEV:0001397 ! Fas signaling pathway
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0000162
name: Estrogen receptor signaling pathway
def: "Any series of molecular signals generated as a consequence of an estrogen binding to its receptor." [GO:0030520]
xref_analog: GO:0030520
is_a: IEV:0001231 ! Steroid receptor signaling pathway
relationship: part_of IEV:0000077 ! Cell cycle

[Term]
id: IEV:0000163
name: fMLP signaling pathway
is_a: IEV:0000661 ! GPCR signaling pathway
relationship: part_of IEV:0000098 ! Immune response

[Term]
id: IEV:0000164
name: Notch signaling pathway
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell." [GO:0007219]
related_synonym: "N signaling pathway" [GO:0007219]
xref_analog: GO:0007219
xref_analog: KEGG:hsa04330
xref_analog: PubMed:14985712
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000091 ! Cell growth
relationship: part_of IEV:0000397 ! Embryonic development
relationship: part_of IEV:0002609 ! Induction
relationship: part_of IEV:0002610 ! Lateral inhibition

[Term]
id: IEV:0000165
name: p53 signaling pathway (through p21)
is_a: IEV:0000391 ! Negative regulation of G1-S-phase transition pathway
is_a: IEV:0001096 ! Negative regulation of S phase
is_a: IEV:0001103 ! p53 signaling pathway
relationship: part_of IEV:0000077 ! Cell cycle
relationship: part_of IEV:0000872 ! DNA repair
relationship: part_of IEV:0001106 ! G1 phase

[Term]
id: IEV:0000166
name: AKT(PKB)-Bad signaling
related_synonym: "PI3K-AKT(PKB)-Bad signaling" []
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000054 ! Bad inactivation signaling
is_a: IEV:0001699 ! AKT signaling
relationship: part_of IEV:0000135 ! IL3 signaling pathway (JAK1, JAK2, STAT5)
relationship: part_of IEV:0000140 ! IL7 signaling (JAK1, JAK3, STAT5)
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0000452 ! Insulin receptor signaling pathway (through AKT-Bad signaling)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000866 ! NGF signaling pathway
relationship: part_of IEV:0000867 ! EPO signaling pathway
relationship: part_of IEV:0001262 ! Rho-PI5K signaling
relationship: part_of IEV:0002632 ! VEGF signaling pathway

[Term]
id: IEV:0000167
name: Bax activation signaling
related_synonym: "Activation, translocation and oligomerization of BAX" []
related_synonym: "Bax dimerization signaling" []
xref_analog: GO:0008633
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0000168
name: Endodormancy
relationship: part_of IEV:0000073 ! Bud dormancy

[Term]
id: IEV:0000169
name: Oxidation in unidentified cellular location
is_a: IEV:0000382 ! Oxidation

[Term]
id: IEV:0000170
name: Binding of Bad and Bcl-2/Bcl-xL
related_synonym: "BAD displaces tBID from BCL-2 sequestration" []
is_a: IEV:0000033 ! Binding in the mitochondria membrane
relationship: part_of IEV:0001667 ! Bcl-2/Bcl-xL inactivation signaling

[Term]
id: IEV:0000171
name: Oxidation in cytosol
is_a: IEV:0000382 ! Oxidation

[Term]
id: IEV:0000172
name: Paradormancy
relationship: part_of IEV:0000073 ! Bud dormancy

[Term]
id: IEV:0000173
name: Negative regulation of Fas signaling pathway
is_a: IEV:0000544 ! Regulation of Fas signaling pathway
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000174
name: Binding outside the mitochondria membrane
is_a: IEV:0000013 ! Binding in cytosol
is_a: IEV:0000033 ! Binding in the mitochondria membrane

[Term]
id: IEV:0000175
name: Translocation from mitochondria membrane to cytosol
is_a: IEV:0000985 ! Translocation from mitochondria to cytosol

[Term]
id: IEV:0000176
name: Permeabilization of mitochondria and Translocation of Cyt c from mitochondria to cytosol
related_synonym: "Release of Cytochrome c from mitochondria" []
is_a: IEV:0000984 ! Permeabilization of mitochondria and Translocation of cytochrome c/SMAC from mitochondria to cytosol
is_a: IEV:0000985 ! Translocation from mitochondria to cytosol

[Term]
id: IEV:0000177
name: Negative regulation of Caspase cascade (through mitochondria)
is_a: IEV:0001018 ! Regulation of Caspase cascade (through mitochondria)
is_a: IEV:0001019 ! Negative regulation of Caspase cascade

[Term]
id: IEV:0000178
name: Binding of Cyt c and Apaf1
related_synonym: "Cytochrome C Binds to Apaf-1" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000989 ! Apoptosome formation

[Term]
id: IEV:0000179
name: Binding of Cyt c and Bcl-2/Bcl-xL
relationship: part_of IEV:0000177 ! Negative regulation of Caspase cascade (through mitochondria)

[Term]
id: IEV:0000180
name: Phosphorylation of Bcl-2
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000181
name: Internalization of TGF beta receptor
is_a: IEV:0001505 ! Receptor internalization

[Term]
id: IEV:0000182
name: Gene expression
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000183
name: Transcription
def: "The synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GO:0006350]
xref_analog: GO:0006350
is_a: IEV:0001886 ! Molecular interaction
relationship: part_of IEV:0000182 ! Gene expression

[Term]
id: IEV:0000184
name: Hydrolysis
def: "EC.3 catalyzed process" [XX:<new dbxref>]
related_synonym: "lyase activity" []
xref_analog: EC:3
xref_analog: GO:0016829
is_a: IEV:0002721 ! enzymatic reaction

[Term]
id: IEV:0000185
name: Environmental event
is_a: IEV:0000000 ! Event

[Term]
id: IEV:0000186
name: Binding in unidentified cellular location
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0000187
name: Phosphorylation in unidentified cellular location
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0000188
name: Negative regulation of NF-kappaB signaling (cytoplasmic sequestering)
is_a: IEV:0000552 ! Regulation of NF-kappaB signaling (cytoplasmic sequestering)
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000189
name: Binding of NF-kappaB and specific modules
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000188 ! Negative regulation of NF-kappaB signaling (cytoplasmic sequestering)

[Term]
id: IEV:0000190
name: Induction of (Para) dormancy
relationship: part_of IEV:0000172 ! Paradormancy

[Term]
id: IEV:0000191
name: Binding of IL1 and IL1R complex
def: "Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response." [GO:0004908]
xref_analog: GO:0004909
xref_analog: GO:0005150
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000192
name: Binding of MyD88 and IRAK1
is_a: IEV:0000242 ! Binding of MyD88 and IRAK
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000193
name: Binding of IL-1R complex and Tollip
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000194
name: Binding of MyD88 and IRAK4
is_a: IEV:0000242 ! Binding of MyD88 and IRAK
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000195
name: Binding of IL1-R complex and MyD88
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000196
name: Binding of Tollip and IRAK1
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000197
name: Phosphorylation of IRAK1 by IRAK4
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000198
name: Phosphorylation in plasma membrane
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0000199
name: GDP-GTP exchange in plasma membrane
is_a: IEV:0000223 ! GDP-GTP exchange

[Term]
id: IEV:0000200
name: Binding of IRAK1_p and TRAF6
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000201
name: Binding of IRAK1:TRAF6 and TAK1:TAB1:TAB2
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000202
name: Ubiquitination of TRAF6
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000203
name: Lyase process in cytosol
is_a: IEV:0000917 ! Lyase process

[Term]
id: IEV:0000204
name: Ubiquitination in unidentified cellular location
is_a: IEV:0000012 ! Ubiquitination

[Term]
id: IEV:0000205
name: Ubiquitination of IRAK1_p
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000206
name: Proteasome degradation in plasma membrane
is_a: IEV:0000010 ! Proteasome degradation

[Term]
id: IEV:0000207
name: Proteasome degradation of IRAK1_p
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000208
name: IKK-NF-kappaB cascade
def: "A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase." [GO:0007249]
related_synonym: "Activation of NF-kappaB by PKC" []
related_synonym: "I-kappaB kinase/NF-kappaB cascade" [GO:0007249]
related_synonym: "NF-kappaB activation" [PubMed:14632637]
related_synonym: "NIK-I-kappaB/NF-kappaB cascade" [GO:0007249]
xref_analog: GO:0007249
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
xref_analog: PubMed:15134788
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000209
name: Phosphorylation of NIK by TAK1
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000210
name: Proteasome degradation of I-kappaB
xref_analog: PubMed:15134788
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000211
name: Release of (eco) dormancy
relationship: part_of IEV:0000096 ! Ecodormancy

[Term]
id: IEV:0000212
name: Ubiquitination of I-kappaB_p
xref_analog: PubMed:15134788
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000213
name: Phosphorylation of I-kappaB_p by IKK complex_p
xref_analog: GO:0007252
xref_analog: PubMed:15134788
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000214
name: Binding of NF-kappaB and I-kappaB
xref_analog: GO:0007253
xref_analog: PubMed:15134788
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000215
name: Dissociation of NF-kappaB and I-kappaB
xref_analog: GO:0008588
xref_analog: PubMed:15134788
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000216
name: Nuclear import of NF-kappaB
def: "The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GO:0042348]
related_synonym: "NF-kappaB import into nucleus" []
related_synonym: "NF-kappaB protein-nucleus import" []
related_synonym: "NF-kappaB transport from cytoplasm to nucleus" []
related_synonym: "NF-kappaB-nucleus import" []
xref_analog: GO:0042348
xref_analog: PubMed:15134788
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000217
name: Binding of NF-kappaB and responsive element
xref_analog: PubMed:11973130
is_a: IEV:0002098 ! Binding of transcriptional factor and responsive element
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000783 ! Gene expression by NF-kappaB
relationship: part_of IEV:0002376 ! Expression of antimicrobial peptide by Relish  [Drosophila]
relationship: part_of IEV:0002377 ! Expression of drosomycin by Relish  [Drosophila]
relationship: part_of IEV:0002378 ! Expression of cecropin by Relish [Drosophila]
relationship: part_of IEV:0002379 ! Expression of diptericin by Relish  [Drosophila]
relationship: part_of IEV:0002395 ! Expression of drosocin by Relish  [Drosophila]
relationship: part_of IEV:0002396 ! Expression of attacin by Relish  [Drosophila]
relationship: part_of IEV:0002397 ! Expression of defensin by DIF:Relish  [Drosophila]
relationship: part_of IEV:0003364 ! Expression of antimicrobial peptide by DIF  [Drosophila]
relationship: part_of IEV:0003365 ! Expression of cecropin by DIF  [Drosophila]
relationship: part_of IEV:0003366 ! Expression of drosomycin by DIF  [Drosophila]
relationship: part_of IEV:0003367 ! Expression of diptericin by DIF  [Drosophila]
relationship: part_of IEV:0003368 ! Expression of antimicrobial peptide by DIF:Dorsal  [Drosophila]
relationship: part_of IEV:0003369 ! Expression of antimicrobial peptide by Dorsal  [Drosophila]
relationship: part_of IEV:0003370 ! Expression of drosomycin by Dorsal  [Drosophila]
relationship: part_of IEV:0003420 ! Gene expression of c-FLIP by NF-kappaB

[Term]
id: IEV:0000218
name: Gene expression of cytokine by NF-kappaB
is_a: IEV:0000783 ! Gene expression by NF-kappaB
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000219
name: Translation
def: "The chemical reactions and pathways resulting in the formation of a protein. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GO:0006412]
xref_analog: GO:0006412
is_a: IEV:0001886 ! Molecular interaction
relationship: part_of IEV:0000182 ! Gene expression

[Term]
id: IEV:0000220
name: Unknown process
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000221
name: Metabolic reaction
is_a: IEV:0001886 ! Molecular interaction

[Term]
id: IEV:0000222
name: Myristoylation
def: "Reaction that can affect K or G residues." [MI:0214]
xref_analog: MI:0214
is_a: IEV:0002681 ! lipid addition

[Term]
id: IEV:0000223
name: GDP-GTP exchange
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0000224
name: IL-1 signaling (through JNK cascade)
is_a: IEV:0000110 ! IL1 signaling pathway
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000225
name: Gene expression of cytokine by AP-1
is_a: IEV:0003387 ! Gene expression by AP-1

[Term]
id: IEV:0000226
name: JNK cascade
def: "A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress." [GO:0007254]
xref_analog: GO:0007254
is_a: IEV:0000445 ! MAPKKK cascade
relationship: part_of IEV:0000062 ! JNK signaling (Angiotensin induced)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
relationship: part_of IEV:0000455 ! TNFR1 signaling pathway (through JNK cascade)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)
relationship: part_of IEV:0000865 ! EGF signaling pathway
relationship: part_of IEV:0001257 ! PDGF signaling pathway
relationship: part_of IEV:0002339 ! TGF beta signaling pathway (through TAK1)
relationship: part_of IEV:0002380 ! Drosophila IMD pathway [Drosophila]
relationship: part_of IEV:0002714 ! Toll-like receptor signaling pathway (through JNK cascade)

[Term]
id: IEV:0000227
name: Phosphorylation of MKK4/7 by MAPKKK
def: "The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity in response to phosphorylation by a member of the JUN kinase kinase kinase (JNKKK) family, or another upstream kinase. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress." [GO:0007256]
related_synonym: "activation of JNKK activity" [GO:0007256]
xref_analog: GO:0007256
is_a: IEV:0000474 ! Phosphorylation of MAPKK by MAPKKK
relationship: part_of IEV:0000226 ! JNK cascade

[Term]
id: IEV:0000228
name: Phosphorylation of JNK by MKK4/7_p
xref_analog: GO:0007257
is_a: IEV:0002095 ! Phosphorylation of JNK by MKK_p
relationship: part_of IEV:0000161 ! Fas signaling pathway (through caspase cascade)

[Term]
id: IEV:0000229
name: Nuclear import of JNK_p
is_a: IEV:0000480 ! Nuclear import of MAPK (through MAPKKK cascade)
relationship: part_of IEV:0000226 ! JNK cascade

[Term]
id: IEV:0000230
name: Phosphorylation of c-Jun by JNK_p
def: "The process of introducing a phosphoric group into a JUN protein." [GO:0007258]
xref_analog: GO:0007258
is_a: IEV:0001082 ! Phosphorylation in the inner space of the nuclear
is_a: IEV:0003403 ! Phosphorylation of transcriptional regulator by JNK_p

[Term]
id: IEV:0000231
name: Phosphorylation in nucleus
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0000232
name: IL-1 signaling (through p38 cascade)
is_a: IEV:0000110 ! IL1 signaling pathway
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000233
name: Gene expression by transcriptional regulator
is_a: IEV:0000182 ! Gene expression
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0000234
name: p38 cascade
is_a: IEV:0000445 ! MAPKKK cascade
relationship: part_of IEV:0000108 ! Toll-like receptor signaling pathway (p38 cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)
relationship: part_of IEV:0002339 ! TGF beta signaling pathway (through TAK1)

[Term]
id: IEV:0000235
name: Phosphorylation of p38 by MKK3/6_p
is_a: IEV:0002106 ! Phosphorylation of p38 by MKK_p

[Term]
id: IEV:0000236
name: Phosphorylation of MKK3/6 by MAPKKK
is_a: IEV:0000474 ! Phosphorylation of MAPKK by MAPKKK
relationship: part_of IEV:0000234 ! p38 cascade

[Term]
id: IEV:0000237
name: Nuclear import of p38_p
is_a: IEV:0000480 ! Nuclear import of MAPK (through MAPKKK cascade)
relationship: part_of IEV:0000234 ! p38 cascade

[Term]
id: IEV:0000238
name: Phosphorylation of transcriptional regulator by p38_p
is_a: IEV:0000479 ! Phosphorylation of transcriptional regulator by MAPK_p
is_a: IEV:0001082 ! Phosphorylation in the inner space of the nuclear
relationship: part_of IEV:0000234 ! p38 cascade

[Term]
id: IEV:0000239
name: Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000098 ! Immune response
relationship: part_of IEV:0000462 ! Toll-like receptor signaling pathway

[Term]
id: IEV:0000240
name: Binding of LPS and TLR4:MD-2:CD14
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000241
name: Binding of TLR4:MD-2:CD14 and MyD88
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000242
name: Binding of MyD88 and IRAK
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000243
name: Activation of IRAK
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000244
name: Activation in plasma membrane
is_a: IEV:0000008 ! Unknown activation

[Term]
id: IEV:0000245
name: Inactivation in extracellular
is_a: IEV:0000007 ! Unknown inactivation

[Term]
id: IEV:0000246
name: Inactivation in unidentified cellular location
is_a: IEV:0000007 ! Unknown inactivation

[Term]
id: IEV:0000247
name: Binding of activated IRAK and TRAF6
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000248
name: Binding of TRAF6 and TAB1:TAB2:TAK1
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000249
name: Reduction in cytosol
is_a: IEV:0000916 ! Reduction

[Term]
id: IEV:0000250
name: Phosphorylation of IKK complex by MAPKKK
xref_analog: GO:0007250
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0001379 ! IKK activation signaling
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0000251
name: Binding of TNF homotrimer and TNFR1
related_synonym: "TNF Binds TNF-R1" []
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000114 ! TNFR1 signaling pathway (through caspase cascade)
relationship: part_of IEV:0000455 ! TNFR1 signaling pathway (through JNK cascade)

[Term]
id: IEV:0000253
name: Trimerization of TNFR1
related_synonym: "TNFR1 trimerization" []
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000114 ! TNFR1 signaling pathway (through caspase cascade)
relationship: part_of IEV:0000455 ! TNFR1 signaling pathway (through JNK cascade)

[Term]
id: IEV:0000254
name: Binding of TNFR1 trimer and TRADD
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000932 ! Binding of TNFR1, TRADD, TRAF2 and RIP

[Term]
id: IEV:0000255
name: Binding of TRADD and TRAF2
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000932 ! Binding of TNFR1, TRADD, TRAF2 and RIP

[Term]
id: IEV:0000256
name: Activation of RIP by TRAF2
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000257
name: Activation of MEKK3 by RIP
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)

[Term]
id: IEV:0000258
name: Complex formation of TCR-CD3
related_synonym: "TCR-CD3 complex formation" []
xref_analog: PubMed:15343367
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000259
name: Binding of antigen, TCR-CD3 complex and CD4
xref_analog: PubMed:15343367
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
relationship: part_of IEV:0001479 ! CD28 signaling

[Term]
id: IEV:0000260
name: Binding of TCR-CD3 complex and Lck
is_a: IEV:0001252 ! Binding of TCR-CD3 complex and non-receptor tyrosine kinase

[Term]
id: IEV:0000262
name: Binding of TCR-CD3 complex and Fyn
is_a: IEV:0001252 ! Binding of TCR-CD3 complex and non-receptor tyrosine kinase

[Term]
id: IEV:0000263
name: Phosphorylation of LAT by ZAP-70_p
xref_analog: PubMed:15343367
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000264
name: Phosphorylation of Vav by non-receptor tyrosine kinase
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000265
name: Phosphorylation of Vav by PI3K
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000266
name: Phosphorylation of ZAP-70 by autophosphorylated Lck
xref_analog: PubMed:12040176
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0000573 ! Phosphorylation of ZAP-70 by non-receptor tyrosine kinase

[Term]
id: IEV:0000267
name: Binding of LAT_p and PLC gamma
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000268
name: Hydrolysis of PIP2 by PLC gamma to generate DAG and IP3
is_a: IEV:0000472 ! Hydrolysis of PIP2 by PLC to generate DAG and IP3
relationship: part_of IEV:0000467 ! PLC gamma signaling
relationship: part_of IEV:0002626 ! FGF signaling pathway
relationship: part_of IEV:0002632 ! VEGF signaling pathway

[Term]
id: IEV:0000269
name: Hydrolysis in plasma membrane
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0000270
name: Binding of DAG and PKC and active conformational change of PKC
xref_analog: PubMed:7499357
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000779 ! PKC activation signaling
relationship: part_of IEV:0002484 ! Activation of PKC by DAG

[Term]
id: IEV:0000272
name: Binding of IP3 and IP3R and IP3R opening
is_a: IEV:0000770 ! Channel opening/closing in the ER membrane
is_a: IEV:0001037 ! Binding outside the ER membrane
relationship: part_of IEV:0000772 ! Cytosolic calcium ion concentration elevation (through IP3 receptor)

[Term]
id: IEV:0000273
name: Binding in the ER membrane
is_a: IEV:0001035 ! Binding in ER

[Term]
id: IEV:0000274
name: Calcium ion transport from ER to cytosol through calcium  ion channel
is_a: IEV:0000739 ! Ion transport through ion channel
is_a: IEV:0001943 ! Translocation from ER to cytosol
relationship: part_of IEV:0000772 ! Cytosolic calcium ion concentration elevation (through IP3 receptor)

[Term]
id: IEV:0000276
name: Heterotrimeric GPCR signaling pathway (through PACAP, G alpha s and adenylate cyclase, cAMP and PKA)
is_a: IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)

[Term]
id: IEV:0000277
name: Trimerization of MALT1:MAGUK:BCL10
xref_analog: PubMed:11973130
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0000278
name: Binding of CD28 and CD80/CD86
xref_analog: ISBN:081533642X
xref_analog: PubMed:15343367
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001479 ! CD28 signaling

[Term]
id: IEV:0000279
name: Reduction in unidentified cellular location
is_a: IEV:0000916 ! Reduction

[Term]
id: IEV:0000280
name: CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000460 ! T cell receptor signaling pathway

[Term]
id: IEV:0000281
name: CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000460 ! T cell receptor signaling pathway
relationship: part_of IEV:0002258 ! Actin filament reorganization during cell cycle

[Term]
id: IEV:0000282
name: Activation of TAK1
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000283
name: Binding of RTK and PLC gamma
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000830 ! RTK signaling pathway

[Term]
id: IEV:0000284
name: Binding of PLC and PIP3
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000471 ! PLC signaling

[Term]
id: IEV:0000286
name: Phosphorylation of PLC gamma by non-receptor tyrosine kinase
alt_id: IEV:0000285
related_synonym: "Phosphorylation of PLC gamma by syk" []
xref_analog: PubMed:14993283
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000467 ! PLC gamma signaling

[Term]
id: IEV:0000287
name: Negative regulation of PLC gamma signaling (through LAT)
is_a: IEV:0000554 ! Regulation of PLC gamma signaling
is_a: IEV:0001408 ! Negative regulation of PLC signaling
is_a: IEV:0001797 ! Negative regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0000288
name: Phosphorylation of PIP2 by PI3K
is_a: IEV:0000198 ! Phosphorylation in plasma membrane
is_a: IEV:0000624 ! Phosphorylation outside the mitochondria membrane
relationship: part_of IEV:0000287 ! Negative regulation of PLC gamma signaling (through LAT)
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001484 ! AKT(PKB) activation signaling
relationship: part_of IEV:0002252 ! Negative regulation of (Phosphorylation of PIP2 by PI3K)

[Term]
id: IEV:0000289
name: Binding of LAT_p and Grads
xref_analog: PubMed:15343367
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000291
name: Activation of IKK complex by PKC theta
def: "The Physical Association of Protein Kinase Ctheta with a Lipid Raft-Associated Inhibitor of kB Factor Kinase (IKK) Complex Plays a Role in the Activation of the NF-kB Cascade by TCR and CD28" [PubMed:11120819]
related_synonym: "Activation of NF-kappaB by PKC" []
related_synonym: "NF-kappaB activation" [PubMed:14632637]
xref_analog: PubMed:11120819
xref_analog: PubMed:11973130
is_a: IEV:0002317 ! Activation of IKK complex by PKCs

[Term]
id: IEV:0000292
name: Medication
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0000293
name: Medium condition
is_a: IEV:0000185 ! Environmental event

[Term]
id: IEV:0000294
name: Plant hormone medication
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0000295
name: KBM (medium)
is_a: IEV:0000316 ! Epidermal keratinocyto medium

[Term]
id: IEV:0000296
name: KBM-2 (medium)
is_a: IEV:0000316 ! Epidermal keratinocyto medium

[Term]
id: IEV:0000297
name: MEGM (medium)
is_a: IEV:0000353 ! Mammary epithelial cell medium

[Term]
id: IEV:0000298
name: MEBM (medium)
is_a: IEV:0000353 ! Mammary epithelial cell medium

[Term]
id: IEV:0000299
name: BEBM (medium)
is_a: IEV:0000352 ! Human bronchial epithelial cell medium

[Term]
id: IEV:0000300
name: SABM (medium)
is_a: IEV:0000352 ! Human bronchial epithelial cell medium

[Term]
id: IEV:0000301
name: PrEGM (medium)
is_a: IEV:0000354 ! Human prostate epithelial cell medium

[Term]
id: IEV:0000302
name: PrEBM (medium)
is_a: IEV:0000354 ! Human prostate epithelial cell medium

[Term]
id: IEV:0000303
name: ES medium
is_a: IEV:0000345 ! waiting (medium)

[Term]
id: IEV:0000304
name: DMEM (medium)
is_a: IEV:0000311 ! ES cell medium

[Term]
id: IEV:0000305
name: 199 medium
is_a: IEV:0000341 ! Chicken aortic smooth muscle cell medium
is_a: IEV:0000342 ! Fibroblast medium

[Term]
id: IEV:0000306
name: Animal cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000307
name: KGM-2 (medium)
is_a: IEV:0000316 ! Epidermal keratinocyto medium

[Term]
id: IEV:0000308
name: Rat cell medium
is_a: IEV:0000306 ! Animal cell medium

[Term]
id: IEV:0000309
name: Mouse cell medium
is_a: IEV:0000306 ! Animal cell medium

[Term]
id: IEV:0000310
name: Neuronal cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000311
name: ES cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000312
name: HeLa medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000313
name: BME medium
is_a: IEV:0000312 ! HeLa medium
is_a: IEV:0000314 ! Mouse L-cell medium

[Term]
id: IEV:0000314
name: Mouse L-cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000315
name: Hepatocyte medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000316
name: Epidermal keratinocyto medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000317
name: Macrophage medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000318
name: Amniocyte medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000319
name: Peripheral blood medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000320
name: Bone marrow medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000321
name: Human hematopoietic cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000322
name: Lymphocyte medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000323
name: CHO medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000324
name: DG44 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000325
name: 293 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000326
name: COS-7 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000327
name: MDCK medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000328
name: VERO medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000329
name: BHK-21 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000330
name: PK-15 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000331
name: CV-1 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000332
name: WI-38 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000333
name: Hybridoma cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000334
name: HEp2 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000335
name: A549 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000336
name: BSC-1 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000337
name: Ham's F-10 medium
is_a: IEV:0000323 ! CHO medium
is_a: IEV:0000333 ! Hybridoma cell medium
is_a: IEV:0000338 ! Myeloma medium

[Term]
id: IEV:0000338
name: Myeloma medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000339
name: Ham's F-12 medium
is_a: IEV:0000323 ! CHO medium
is_a: IEV:0000333 ! Hybridoma cell medium
is_a: IEV:0000338 ! Myeloma medium

[Term]
id: IEV:0000340
name: IMDM (medium)
is_a: IEV:0000322 ! Lymphocyte medium
is_a: IEV:0000333 ! Hybridoma cell medium

[Term]
id: IEV:0000341
name: Chicken aortic smooth muscle cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000342
name: Fibroblast medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000343
name: All-purpose medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000344
name: MEM (medium)
is_a: IEV:0000343 ! All-purpose medium

[Term]
id: IEV:0000345
name: waiting (medium)
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000346
name: Alpha MEM (medium)
is_a: IEV:0000333 ! Hybridoma cell medium

[Term]
id: IEV:0000347
name: RPMI 1640 medium
is_a: IEV:0000345 ! waiting (medium)

[Term]
id: IEV:0000348
name: Jurkat cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000349
name: HL60 medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000350
name: Waymouth's medium
is_a: IEV:0000314 ! Mouse L-cell medium

[Term]
id: IEV:0000351
name: Mesenchymal cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000352
name: Human bronchial epithelial cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000353
name: Mammary epithelial cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000354
name: Human prostate epithelial cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000355
name: SAGM (medium)
is_a: IEV:0000352 ! Human bronchial epithelial cell medium

[Term]
id: IEV:0000356
name: BEGM (medium)
is_a: IEV:0000352 ! Human bronchial epithelial cell medium

[Term]
id: IEV:0000357
name: KGM (medium)
is_a: IEV:0000316 ! Epidermal keratinocyto medium

[Term]
id: IEV:0000358
name: Fisher medium
is_a: IEV:0000345 ! waiting (medium)

[Term]
id: IEV:0000359
name: Leibovitz's L-15 medium
is_a: IEV:0000345 ! waiting (medium)

[Term]
id: IEV:0000360
name: NCTC135 medium
is_a: IEV:0000345 ! waiting (medium)

[Term]
id: IEV:0000361
name: Williams's medium
is_a: IEV:0000345 ! waiting (medium)

[Term]
id: IEV:0000362
name: Human vascular smooth muscle medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000363
name: Human vascular endothelial cell medium
is_a: IEV:0000293 ! Medium condition

[Term]
id: IEV:0000364
name: McCoy's medium
is_a: IEV:0000345 ! waiting (medium)

[Term]
id: IEV:0000365
name: Cambium dormancy
is_a: IEV:0000072 ! Dormancy

[Term]
id: IEV:0000366
name: Cell cycle regulation pathway
xref_analog: KEGG:hsa04110
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000077 ! Cell cycle

[Term]
id: IEV:0000367
name: G1-S-phase transition process [Plant]
is_a: IEV:0001070 ! G1-S-phase transition pathway
relationship: part_of IEV:0000211 ! Release of (eco) dormancy

[Term]
id: IEV:0000368
name: G2-M-phase transition pathway
def: "Progression from G2 phase to M phase of the mitotic cell cycle." [GO:0000086]
xref_analog: GO:0000086
xref_analog: KEGG:hsa04110
is_a: IEV:0000366 ! Cell cycle regulation pathway

[Term]
id: IEV:0000369
name: Binding of Cdk A and cyclin D
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000367 ! G1-S-phase transition process [Plant]

[Term]
id: IEV:0000370
name: Phosphorylation of Cdk A by CAK
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000367 ! G1-S-phase transition process [Plant]

[Term]
id: IEV:0000371
name: Temperature treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0000372
name: Radiation treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0000373
name: Wavelength of light treatment
is_a: IEV:0000372 ! Radiation treatment

[Term]
id: IEV:0000374
name: Photoperiod treatment
is_a: IEV:0000372 ! Radiation treatment

[Term]
id: IEV:0000375
name: Freeze treatment
is_a: IEV:0000378 ! Low temperature treatment

[Term]
id: IEV:0000376
name: Cold temperature treatment
is_a: IEV:0000378 ! Low temperature treatment

[Term]
id: IEV:0000377
name: High temperature treatment
is_a: IEV:0000371 ! Temperature treatment

[Term]
id: IEV:0000378
name: Low temperature treatment
is_a: IEV:0000371 ! Temperature treatment

[Term]
id: IEV:0000379
name: Heat treatment
is_a: IEV:0000371 ! Temperature treatment

[Term]
id: IEV:0000380
name: Physical stimulus treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0000381
name: Gravity treatment
is_a: IEV:0000380 ! Physical stimulus treatment

[Term]
id: IEV:0000382
name: Oxidation
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0000383
name: Contact pressure treatment
is_a: IEV:0000380 ! Physical stimulus treatment

[Term]
id: IEV:0000384
name: Magnetic force treatment
is_a: IEV:0000380 ! Physical stimulus treatment

[Term]
id: IEV:0000385
name: Electricity treatment
is_a: IEV:0000380 ! Physical stimulus treatment

[Term]
id: IEV:0000386
name: FK506 medication
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0000387
name: Treatment
is_a: IEV:0000185 ! Environmental event

[Term]
id: IEV:0000388
name: Nuclear import of Cdk A_Tp:cyclin D
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000367 ! G1-S-phase transition process [Plant]

[Term]
id: IEV:0000389
name: Phosphorylation of RB by Cdk A_Tp
is_a: IEV:0001082 ! Phosphorylation in the inner space of the nuclear
relationship: part_of IEV:0000367 ! G1-S-phase transition process [Plant]

[Term]
id: IEV:0000390
name: Dissociation of E2F and RB_p
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000367 ! G1-S-phase transition process [Plant]
relationship: part_of IEV:0001070 ! G1-S-phase transition pathway
relationship: part_of IEV:0001095 ! S phase pathway

[Term]
id: IEV:0000391
name: Negative regulation of G1-S-phase transition pathway
is_a: IEV:0000546 ! Regulation of G1-S-phase transition pathway
is_a: IEV:0001404 ! Negative regulation of cell cycle regulation

[Term]
id: IEV:0000392
name: Ubiquitination of Cyclin D
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0001084 ! Cyclin D degradation signaling

[Term]
id: IEV:0000393
name: DNA replication
def: "The process whereby new strands of DNA are synthesized. The template for replication can either be DNA or RNA." [GO:0006260]
xref_analog: GO:0006260
relationship: part_of IEV:0000077 ! Cell cycle

[Term]
id: IEV:0000394
name: CoA ligation
xref_analog: EC:6.2.1
is_a: IEV:0000912 ! Ligation

[Term]
id: IEV:0000396
name: Lignin biosynthesis
def: "The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers." [GO:0009809]
related_synonym: "lignin anabolism" []
related_synonym: "lignin biosynthetic process" []
related_synonym: "lignin formation" []
related_synonym: "lignin synthesis" []
xref_analog: GO:0009809
is_a: IEV:0000818 ! Metabolic pathway
relationship: part_of IEV:0002216 ! Cell wall organization and biosynthesis

[Term]
id: IEV:0000397
name: Embryonic development
def: "Processes aimed at the progression of an embryo from zygote formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific and may be somewhat arbitrary. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GO:0009790]
xref_analog: GO:0009790
is_a: IEV:0000083 ! Development

[Term]
id: IEV:0000398
name: Post embryonic development
def: "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GO:0009791]
xref_analog: GO:0009791
is_a: IEV:0000083 ! Development

[Term]
id: IEV:0000400
name: Binding of c-AMP and PKA regulatory subunits and active conformational change
alt_id: IEV:0000781
related_synonym: "Dissociation of PKA catalytic subunit and regulatory subunit" []
xref_analog: PubMed:15023366
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000780 ! PKA activation signaling

[Term]
id: IEV:0000401
name: Phosphorylation of Bad by PKA
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000055 ! PKA-Bad signaling

[Term]
id: IEV:0000402
name: Phosphorylation of caspase9 by AKT
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)
relationship: part_of IEV:0001707 ! AKT(PKB)-caspase signaling

[Term]
id: IEV:0000403
name: Phosphorylation of Bad by AKT_p
related_synonym: "Akt1 phosphorylates BAD protein" []
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0000624 ! Phosphorylation outside the mitochondria membrane
relationship: part_of IEV:0000166 ! AKT(PKB)-Bad signaling

[Term]
id: IEV:0000404
name: Binding of Bad_p and 14-3-3
related_synonym: "Sequesteration of BAD protein by 14-3-3" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000055 ! PKA-Bad signaling
relationship: part_of IEV:0000056 ! RSK-Bad signaling
relationship: part_of IEV:0000166 ! AKT(PKB)-Bad signaling

[Term]
id: IEV:0000405
name: Translocation of Bad_p from mitochondria membrane to cytosol
is_a: IEV:0000175 ! Translocation from mitochondria membrane to cytosol
relationship: part_of IEV:0000055 ! PKA-Bad signaling
relationship: part_of IEV:0000056 ! RSK-Bad signaling
relationship: part_of IEV:0000166 ! AKT(PKB)-Bad signaling

[Term]
id: IEV:0000406
name: Bad activation signaling
related_synonym: "Activation of BAD and translocation to mitochondria" []
related_synonym: "Bad dephosphorylation signaling" []
xref_analog: GO:0008633
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0001667 ! Bcl-2/Bcl-xL inactivation signaling

[Term]
id: IEV:0000407
name: Oxidation of ferulate
is_a: IEV:0000171 ! Oxidation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000408
name: Phosphorylation of AKT by PDK1
is_a: IEV:0000624 ! Phosphorylation outside the mitochondria membrane
is_a: IEV:0002415 ! Phosphorylation of Akt by protein kinase

[Term]
id: IEV:0000409
name: Removement of survival factor
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0000411
name: Translocation of Bad from the cytosol to the mitochondria membrane
related_synonym: "Translocation of activated BAD protein to mitochondria" []
xref_analog: GO:0001844
is_a: IEV:0000412 ! Translocation from cytosol to mitochondria membrane
relationship: part_of IEV:0001667 ! Bcl-2/Bcl-xL inactivation signaling

[Term]
id: IEV:0000412
name: Translocation from cytosol to mitochondria membrane
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000413
name: Dephosphorylation of Bad_p by calcineurin
related_synonym: "Activation of BAD by calcineurin" []
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0000406 ! Bad activation signaling

[Term]
id: IEV:0000414
name: Dephosphorylation in plasma membrane
is_a: IEV:0000011 ! Dephosphorylation

[Term]
id: IEV:0000415
name: Oxidation of 4-coumarate
is_a: IEV:0000171 ! Oxidation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000416
name: Peroxidation of 4-Coumaryl alcohol to Lignin (grasses)
is_a: IEV:0000171 ! Oxidation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000417
name: Translocation of Coniferyl alcohol to cell wall
is_a: IEV:0000429 ! Translocation from cytosol to cell wall
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000418
name: Translocation of 4-Coumaryl alcohol to cell wall
is_a: IEV:0000429 ! Translocation from cytosol to cell wall
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000419
name: O-methyltransferase of caffeoyl-CoA by CCR
is_a: IEV:0000435 ! Transmethylation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000420
name: Hydroxylation of trans-cinnamate by C4H
is_a: IEV:0000438 ! Hydroxylation in the cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000421
name: Peroxidation of sinapyl alcohol to Lignin (angiosperm and grasses)
is_a: IEV:0000171 ! Oxidation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000422
name: CoA ligation of caffeic acid by 4CL
is_a: IEV:0000430 ! CoA ligation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000423
name: CoA ligation of 4-coumarate by 4CL
is_a: IEV:0000430 ! CoA ligation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000424
name: CoA ligation of ferulate by 4CL
is_a: IEV:0000430 ! CoA ligation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000425
name: O-methyl-transfer of caffeic acid by OMT
is_a: IEV:0000435 ! Transmethylation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000426
name: CoA ligation of 5-Hydroxyferulate by 4CL
is_a: IEV:0000430 ! CoA ligation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000427
name: Peroxidation of coniferyl alcohol to Lignin (gymnosperm, angiosperm and grasses)
is_a: IEV:0000171 ! Oxidation in cytosol
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000428
name: Translocation of sinapyl alcohol to cell wall
is_a: IEV:0000429 ! Translocation from cytosol to cell wall
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0000429
name: Translocation from cytosol to cell wall
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000430
name: CoA ligation in cytosol
is_a: IEV:0000394 ! CoA ligation

[Term]
id: IEV:0000431
name: CoA ligation inside plasma membrane
is_a: IEV:0000430 ! CoA ligation in cytosol

[Term]
id: IEV:0000432
name: CoA ligation in unidentified cellular location
is_a: IEV:0000394 ! CoA ligation

[Term]
id: IEV:0000433
name: Transmethylation
def: "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer.Irreversible reaction that can affect A,G,M,F,P,C,R,N,Q,E,H,or K residues. " [MI:0213]
xref_analog: EC:2.1.1
xref_analog: MI:0213
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0000434
name: Transmethylation in unidentified cellular location
is_a: IEV:0000433 ! Transmethylation

[Term]
id: IEV:0000435
name: Transmethylation in cytosol
is_a: IEV:0000433 ! Transmethylation

[Term]
id: IEV:0000436
name: Isoprenylation in cytosol
is_a: IEV:0000921 ! Isoprenylation

[Term]
id: IEV:0000437
name: Hydroxylation
def: "Irreversible reaction that can affect K,P,Y  or R residues." [MI:0210]
xref_analog: MI:0210
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0000438
name: Hydroxylation in the cytosol
is_a: IEV:0000437 ! Hydroxylation

[Term]
id: IEV:0000439
name: Hydroxylation in the unidentified cellular location
is_a: IEV:0000437 ! Hydroxylation

[Term]
id: IEV:0000440
name: Farnesylation in cytosol
is_a: IEV:0000919 ! Farnesylation

[Term]
id: IEV:0000441
name: Lignin biosynthesis (angiosperm)
is_a: IEV:0000396 ! Lignin biosynthesis

[Term]
id: IEV:0000442
name: Lignin biosynthesis (gymnosperm)
is_a: IEV:0000396 ! Lignin biosynthesis

[Term]
id: IEV:0000443
name: Lignin biosynthesis (grasses)
is_a: IEV:0000396 ! Lignin biosynthesis

[Term]
id: IEV:0000444
name: Translocation of Bax from the cytosol to the mitochondria membrane
related_synonym: "Translocation of activated BAX to the mitochondria" []
xref_analog: GO:0001844
is_a: IEV:0000412 ! Translocation from cytosol to mitochondria membrane
relationship: part_of IEV:0000167 ! Bax activation signaling

[Term]
id: IEV:0000445
name: MAPKKK cascade
def: "Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways." [GO:0000165]
related_synonym: "MAP kinase cascade" [GO:0000165]
related_synonym: "MAP kinase kinase kinase cascade" [GO:0000165]
related_synonym: "MAPK cascade" []
xref_analog: GO:0000165
xref_analog: KEGG:hsa04010
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000446
name: Phosphorylation of STAT by JAK_p
xref_analog: GO:0007260
xref_analog: PubMed:12039028
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000447
name: Morphogenesis
def: "Developmental processes by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GO:0009653]
related_synonym: "anatomical structure morphogenesis" [GO:0009653]
xref_analog: GO:0009653
is_a: IEV:0000083 ! Development

[Term]
id: IEV:0000448
name: Hematopoiesis
def: "The process of blood cell formation. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GO:0030097]
related_synonym: "Haemopoiesis" []
related_synonym: "Hemopoiesis" []
xref_analog: GO:0030097
is_a: IEV:0000576 ! Organ morphogenesis

[Term]
id: IEV:0000449
name: Negative regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
is_a: IEV:0000556 ! Regulation of Ras-Raf-MAPK signaling by spred [Drosophila]
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000452
name: Insulin receptor signaling pathway (through AKT-Bad signaling)
is_a: IEV:0000487 ! Insulin receptor signaling pathway
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000453
name: Phosphorylation of p53 by ATM
is_a: IEV:0001082 ! Phosphorylation in the inner space of the nuclear
relationship: part_of IEV:0000165 ! p53 signaling pathway (through p21)
relationship: part_of IEV:0001107 ! p53 signaling pathway (through GADD45)
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0000454
name: IGF signaling pathway
def: "The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands." [GO:0048009]
related_synonym: "IGF receptor signaling pathway" [GO:0048009]
related_synonym: "insulin-like growth factor receptor signaling pathway" [GO:0048009]
xref_analog: GO:0048009
xref_analog: PubMed:15205477
is_a: IEV:0000830 ! RTK signaling pathway
is_a: IEV:0001690 ! Negative regulation of caloric restriction - cell survival signaling

[Term]
id: IEV:0000455
name: TNFR1 signaling pathway (through JNK cascade)
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0002408 ! TNFR1 signaling pathway

[Term]
id: IEV:0000456
name: Binding of TRAF2 and ASK1
is_a: IEV:0001725 ! Binding of TRAF2 and MAPKKK
relationship: part_of IEV:0000455 ! TNFR1 signaling pathway (through JNK cascade)

[Term]
id: IEV:0000457
name: Binding of TRADD and FADD
related_synonym: "TRADD:TRAF2:RIP1 complex binds FADD" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000114 ! TNFR1 signaling pathway (through caspase cascade)

[Term]
id: IEV:0000458
name: Protein activation/inactivation signaling
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000459
name: Autophosphorylation in unidentified cellular location
is_a: IEV:0000490 ! Autophosphorylation

[Term]
id: IEV:0000460
name: T cell receptor signaling pathway
def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell." [GO:0050852]
related_synonym: "T lymphocyte receptor signaling pathway" [GO:0050852]
related_synonym: "T-cell receptor signaling pathway" [GO:0050852]
related_synonym: "T-lymphocyte receptor signaling pathway" [GO:0050852]
xref_analog: GO:0050852
xref_analog: KEGG:hsa04660
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000098 ! Immune response

[Term]
id: IEV:0000461
name: Regulation of p53 signaling pathway
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000165 ! p53 signaling pathway (through p21)
relationship: part_of IEV:0001103 ! p53 signaling pathway
relationship: part_of IEV:0001107 ! p53 signaling pathway (through GADD45)
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0000462
name: Toll-like receptor signaling pathway
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GO:0002224]
comment: Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses.
related_synonym: "TLR signaling pathway" [GO:0002224]
xref_analog: GO:0002224
xref_analog: KEGG:hsa04620
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000463
name: Negative regulation of p53 signaling pathway
is_a: IEV:0000461 ! Regulation of p53 signaling pathway
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000464
name: Positive regulation of p53 signaling pathway
is_a: IEV:0000461 ! Regulation of p53 signaling pathway
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000465
name: TNFR signaling pathway
related_synonym: "Death Receptor Signalling" []
related_synonym: "Extrinsic Pathway for Apoptosis" []
related_synonym: "induction of apoptosis by extracellular signals" []
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000466
name: Nuclear import of ERK_p
is_a: IEV:0000480 ! Nuclear import of MAPK (through MAPKKK cascade)
relationship: part_of IEV:0000115 ! ERK cascade

[Term]
id: IEV:0000467
name: PLC gamma signaling
alt_id: IEV:0000058
alt_id: IEV:0000271
alt_id: IEV:0000468
related_synonym: "PLC gamma signaling (through BLNK)" []
related_synonym: "PLC gamma signaling (through LAT)" []
related_synonym: "PLC gamma signaling (through RTK)" []
is_a: IEV:0000471 ! PLC signaling
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
relationship: part_of IEV:0000482 ! CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000469
name: Binding of PLC gamma and PIP3
def: "activation of PLC gamma, PLC gamma_SH2 or PH domain" [XX:<new dbxref>]
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000467 ! PLC gamma signaling

[Term]
id: IEV:0000470
name: Binding of PLC beta and PIP3
is_a: IEV:0000013 ! Binding in cytosol

[Term]
id: IEV:0000471
name: PLC signaling
related_synonym: "phospholipase C signaling" []
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000472
name: Hydrolysis of PIP2 by PLC to generate DAG and IP3
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000471 ! PLC signaling

[Term]
id: IEV:0000473
name: Hydrolysis of PIP2 by PLC beta to generate DAG and IP3
is_a: IEV:0000472 ! Hydrolysis of PIP2 by PLC to generate DAG and IP3
relationship: part_of IEV:0000065 ! PLC beta signaling

[Term]
id: IEV:0000474
name: Phosphorylation of MAPKK by MAPKKK
alt_id: IEV:0002094
def: "The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK. " [GO:0000186]
related_synonym: "activation of MAPKK activity" [GO:0000186]
related_synonym: "Phosphorylation of MKK by MAPKKK" []
xref_analog: GO:0000186
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000445 ! MAPKKK cascade

[Term]
id: IEV:0000475
name: Phosphorylation of MEK1/2(MKK1/2) by MAPKKK
is_a: IEV:0000474 ! Phosphorylation of MAPKK by MAPKKK
relationship: part_of IEV:0000115 ! ERK cascade

[Term]
id: IEV:0000476
name: Phosphorylation of ERK by MEK1/2(MKK1/2)_p
xref_analog: PubMed:14734786
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0002067 ! Phosphorylation of MAPK by MEK

[Term]
id: IEV:0000477
name: Phosphorylation of transcriptional regulator by ERK_p
is_a: IEV:0000479 ! Phosphorylation of transcriptional regulator by MAPK_p
is_a: IEV:0001082 ! Phosphorylation in the inner space of the nuclear
relationship: part_of IEV:0000115 ! ERK cascade

[Term]
id: IEV:0000478
name: Phosphorylation of MAPK by MAPKK
def: "The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK." [GO:0000187]
related_synonym: "activation of MAP kinase" []
related_synonym: "activation of MAPK activity" []
xref_analog: GO:0000187
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000445 ! MAPKKK cascade

[Term]
id: IEV:0000479
name: Phosphorylation of transcriptional regulator by MAPK_p
is_a: IEV:0001082 ! Phosphorylation in the inner space of the nuclear
relationship: part_of IEV:0000445 ! MAPKKK cascade

[Term]
id: IEV:0000480
name: Nuclear import of MAPK (through MAPKKK cascade)
def: "The directed movement of a MAP kinase to the nucleus upon activation." [GO:0000189]
related_synonym: "nuclear translocation of MAPK" []
xref_analog: GO:0000189
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000445 ! MAPKKK cascade

[Term]
id: IEV:0000481
name: Autophosphorylation in cytosol
is_a: IEV:0000490 ! Autophosphorylation

[Term]
id: IEV:0000482
name: CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000460 ! T cell receptor signaling pathway

[Term]
id: IEV:0000483
name: Binding of calcium ion and PKC and active conformational change of PKC
xref_analog: PubMed:7499357
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000779 ! PKC activation signaling

[Term]
id: IEV:0000484
name: Binding of DAG, calcium ion and PKC and active conformational change of PKC
xref_analog: PubMed:7499357
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000779 ! PKC activation signaling

[Term]
id: IEV:0000485
name: Transcription of IL-2
xref_analog: PubMed:11973130
is_a: IEV:0000183 ! Transcription
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000486
name: Autophosphorylation in plasma membrane
is_a: IEV:0000490 ! Autophosphorylation

[Term]
id: IEV:0000487
name: Insulin receptor signaling pathway
def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GO:0008286]
related_synonym: "Insulin receptor mediated signalling" []
xref_analog: GO:0008286
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000488
name: Binding of insulin and insulin receptor
related_synonym: "Insulin binding" []
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000489
name: Autophosphorylation of insulin receptor
xref_analog: GO:0004714
is_a: IEV:0000481 ! Autophosphorylation in cytosol
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000490
name: Autophosphorylation
xref_analog: GO:0046777
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0000491
name: Binding of insulin receptor and Shc
related_synonym: "Binding of SHC to insulin receptor" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000492
name: Phosphorylation of Shc by insulin receptor
related_synonym: "Phosphorylation of SHC" []
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000493
name: Dissociation of Shc and insulin receptor
related_synonym: "Dissociation of SHC-P from insulin receptor" []
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000494
name: Binding of IRS and insulin receptor
related_synonym: "Binding of IRS to insulin receptor" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000495
name: Phosphorylation of IRS by insulin receptor
related_synonym: "Phosphorylation of IRS" []
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000496
name: Dissociation of IRS and insulin receptor
related_synonym: "Dissociation of IRS-P from insulin receptor" []
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000497
name: Internalisation of the insulin receptor
is_a: IEV:0000508 ! Translocation from plasma membrane to cytosol
is_a: IEV:0001505 ! Receptor internalization
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000498
name: Insulin receptor recycling
is_a: IEV:0001255 ! Receptor recycling
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000499
name: Influx of hydrogen ion into the lumen of the endosome by proton pump
related_synonym: "Endosome acidification" []
is_a: IEV:0000504 ! Translocation from cytosol into lumen of endosome
relationship: part_of IEV:0000498 ! Insulin receptor recycling

[Term]
id: IEV:0000500
name: Dissociation of insulin and insulin receptor
related_synonym: "Dissociation of insulin from insulin receptor" []
is_a: IEV:0000506 ! Dissociation in extracellular
relationship: part_of IEV:0000498 ! Insulin receptor recycling

[Term]
id: IEV:0000501
name: Negative regulation of insulin signaling pathway
def: "Any process that stops, prevents or reduces the frequency, rate or extent of insulin receptor signaling." [GO:0046627]
xref_analog: GO:0046627
is_a: IEV:0000548 ! Regulation of insulin receptor signaling pathway
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000502
name: Dephosphorylation of Insulin receptor by PTP
related_synonym: "Insulin receptor de-phosphorylation" []
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0000498 ! Insulin receptor recycling
relationship: part_of IEV:0000501 ! Negative regulation of insulin signaling pathway

[Term]
id: IEV:0000503
name: Translocation of insulin receptor from the endosome to plasma membrane
related_synonym: "Re-integration of insulin receptor into plasma membrane" []
is_a: IEV:0000505 ! Translocation from endosome to plasma membrane
relationship: part_of IEV:0000498 ! Insulin receptor recycling

[Term]
id: IEV:0000504
name: Translocation from cytosol into lumen of endosome
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000505
name: Translocation from endosome to plasma membrane
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000506
name: Dissociation in extracellular
is_a: IEV:0000006 ! Dissociation

[Term]
id: IEV:0000507
name: Dissociation in unidentified cellular location
is_a: IEV:0000006 ! Dissociation

[Term]
id: IEV:0000508
name: Translocation from plasma membrane to cytosol
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000509
name: Dephosphorylation of Lck_p (phosphorylated in the C-terminal phosphorylation site) by CD45 and active conformational change
xref_analog: PubMed:11781344
xref_analog: PubMed:12040176
is_a: IEV:0001599 ! Dephosphorylation of Lck_p (phosphorylated in the C-terminal phosphorylation site) by PTP and active conformational change

[Term]
id: IEV:0000510
name: Autophosphorylation of Lck and active conformational change
xref_analog: PubMed:11781344
xref_analog: PubMed:15034556
is_a: IEV:0001607 ! Autophosphorylation of Src family and active conformational change
relationship: part_of IEV:0000519 ! Lck activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0000511
name: Binding of CD4 and Lck
xref_analog: PubMed:15343367
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0001479 ! CD28 signaling

[Term]
id: IEV:0000512
name: Negative regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0000542 ! Regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0001375 ! Negative regulation of T cell receptor signaling pathway

[Term]
id: IEV:0000513
name: Lck inactivation signaling (through PTP)
xref_analog: PubMed:11781344
xref_analog: PubMed:12040176
xref_analog: PubMed:15034556
is_a: IEV:0001620 ! Negative regulation of Src activation signaling
is_a: IEV:0001635 ! Lck inactivation signaling
is_a: IEV:0001894 ! Negative regulation of (phosphorylation of Lck) Lck activation signaling (autophosphorylation and PTP)
is_a: IEV:0002255 ! Negative regulation of (Lck activation signaling)

[Term]
id: IEV:0000514
name: Phosphorylation of PAG/Cbp by (autophosphorylated) Fyn
xref_analog: PubMed:11781344
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000513 ! Lck inactivation signaling (through PTP)
relationship: part_of IEV:0001890 ! Lck inactivation signaling (through Csk)

[Term]
id: IEV:0000515
name: Binding of PAG/Cbp_p and Csk
xref_analog: PubMed:11781344
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000513 ! Lck inactivation signaling (through PTP)
relationship: part_of IEV:0001890 ! Lck inactivation signaling (through Csk)

[Term]
id: IEV:0000516
name: Binding of Csk and PEP
xref_analog: PubMed:11781344
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000513 ! Lck inactivation signaling (through PTP)
relationship: part_of IEV:0001890 ! Lck inactivation signaling (through Csk)

[Term]
id: IEV:0000517
name: DNA fragmentation by EndoG
is_a: IEV:0001051 ! Hydrolysis in the inner space of the nuclear
relationship: part_of IEV:0001602 ! EndoG mediated signaling

[Term]
id: IEV:0000518
name: Dephosphorylation of Lck_p (autophosphorylated) by PEP
xref_analog: PubMed:11781344
is_a: IEV:0001592 ! Dephosphorylation of Lck_p (autophosphorylated) by PTP

[Term]
id: IEV:0000519
name: Lck activation signaling (through autophosphorylation and PTP)
xref_analog: PubMed:11781344
xref_analog: PubMed:12040176
xref_analog: PubMed:15034556
is_a: IEV:0001606 ! Src family activation signaling (through autophosphorylation and PTP)
is_a: IEV:0001610 ! Lck activation signaling
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000520
name: Regulation of Src family activation signaling
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0001589 ! Src family activation signaling

[Term]
id: IEV:0000521
name: Binding of MHC II and antigen
xref_analog: PubMed:15343367
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000522
name: Phosphorylation of CD3 zeta by Lck (autophosphorylated)
xref_analog: PubMed:12040176
is_a: IEV:0001253 ! Phosphorylation of CD3 zeta by non-receptor tyrosine kinase

[Term]
id: IEV:0000523
name: Phosphorylation of CD3 zeta by Fyn (autophosphorylated)
is_a: IEV:0001253 ! Phosphorylation of CD3 zeta by non-receptor tyrosine kinase

[Term]
id: IEV:0000524
name: Binding of CD3 zeta and ZAP-70
alt_id: IEV:0000261
related_synonym: "Binding of TCR-CD3 complex and Zap-70" []
xref_analog: PubMed:15343367
is_a: IEV:0000013 ! Binding in cytosol
is_a: IEV:0001252 ! Binding of TCR-CD3 complex and non-receptor tyrosine kinase
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
relationship: part_of IEV:0001479 ! CD28 signaling

[Term]
id: IEV:0000525
name: Phosphorylation of ZAP-70 by autophosphorylated Fyn
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0000573 ! Phosphorylation of ZAP-70 by non-receptor tyrosine kinase

[Term]
id: IEV:0000526
name: Dephosphorylation of ZAP-70_p by SHIP-1
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0002251 ! Negative regulation of (Phosphorylation of ZAP-70 by Lck_PY)

[Term]
id: IEV:0000527
name: Phosphorylation of SLP-76 by ZAP-70_p
alt_id: IEV:0000290
related_synonym: "Phosphorylation of SLP-76 by Zap-70" []
xref_analog: PubMed:15343367
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000528
name: Binding of Gads and SLP-76
xref_analog: PubMed:15343367
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000529
name: Phosphorylation of PLC gamma1 by Itk
def: "T-cell" [XX:<new dbxref>]
xref_analog: PubMed:11752630
is_a: IEV:0000286 ! Phosphorylation of PLC gamma by non-receptor tyrosine kinase

[Term]
id: IEV:0000530
name: Phosphorylation of PLC gamma by Syk
xref_analog: PubMed:14632637
is_a: IEV:0000286 ! Phosphorylation of PLC gamma by non-receptor tyrosine kinase

[Term]
id: IEV:0000531
name: Binding of SLP-76 and Itk
xref_analog: PubMed:12040176
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000532
name: Phosphorylation of PI by PI4K
is_a: IEV:0000198 ! Phosphorylation in plasma membrane
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000533
name: Phosphorylation of PIP by PI5K
is_a: IEV:0000198 ! Phosphorylation in plasma membrane
relationship: part_of IEV:0001262 ! Rho-PI5K signaling

[Term]
id: IEV:0000534
name: Binding of PIP2 and actin-binding protein
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000535
name: Fyn activation signaling (through autophosphorylation and PTP)
xref_analog: PubMed:15034556
is_a: IEV:0001606 ! Src family activation signaling (through autophosphorylation and PTP)
is_a: IEV:0001609 ! Fyn activation signaling
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000536
name: Autophosphorylation of Fyn and active conformational change
xref_analog: PubMed:15034556
is_a: IEV:0001607 ! Autophosphorylation of Src family and active conformational change
relationship: part_of IEV:0000535 ! Fyn activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0000537
name: Interaction in nucleus
is_a: IEV:0000922 ! Unknown interaction

[Term]
id: IEV:0000538
name: Regulation of BAD inactivation signaling
related_synonym: "Regulation of BAD phosphorylation signaling" []
is_obsolete: true

[Term]
id: IEV:0000539
name: Regulation of Caspase cascade
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000128 ! Caspase Cascade

[Term]
id: IEV:0000540
name: Positive regulation of BAD inactivation signaling
related_synonym: "Positive regulation of BAD phosphorylation signaling" []
is_obsolete: true

[Term]
id: IEV:0000541
name: Positive regulation of Caspase cascade (through mitochondria)
is_a: IEV:0001018 ! Regulation of Caspase cascade (through mitochondria)
is_a: IEV:0001020 ! Positive regulation of Caspase cascade

[Term]
id: IEV:0000542
name: Regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0001374 ! Regulation of T cell receptor signaling pathway
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000543
name: Positive regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0000542 ! Regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0001376 ! Positive regulation of T cell receptor signaling pathway

[Term]
id: IEV:0000544
name: Regulation of Fas signaling pathway
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0001397 ! Fas signaling pathway

[Term]
id: IEV:0000545
name: Positive regulation of Fas signaling pathway
is_a: IEV:0000544 ! Regulation of Fas signaling pathway
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000546
name: Regulation of G1-S-phase transition pathway
is_a: IEV:0001403 ! Regulation of cell cycle regulation
relationship: part_of IEV:0001070 ! G1-S-phase transition pathway

[Term]
id: IEV:0000547
name: Positive regulation of G1-S-phase transition pathway
is_a: IEV:0000546 ! Regulation of G1-S-phase transition pathway
is_a: IEV:0001405 ! Positive regulation of cell cycle regulation

[Term]
id: IEV:0000548
name: Regulation of insulin receptor signaling pathway
def: "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GO:0046626]
xref_analog: GO:0046626
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway

[Term]
id: IEV:0000549
name: Positive regulation of insulin receptor signaling pathway
def: "Any process that increases the frequency, rate or extent of insulin receptor signaling." [GO:0046628]
xref_analog: GO:0046628
is_a: IEV:0000548 ! Regulation of insulin receptor signaling pathway
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000550
name: Regulation of JAK STAT pathway
def: "Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GO:0046425]
xref_analog: GO:0046425
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000551
name: Positive regulation of JAK STAT pathway
def: "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GO:0046427]
xref_analog: GO:0046427
is_a: IEV:0000550 ! Regulation of JAK STAT pathway
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000552
name: Regulation of NF-kappaB signaling (cytoplasmic sequestering)
is_a: IEV:0000145 ! Regulation pathway

[Term]
id: IEV:0000553
name: Positive regulation of NF-kappaB signaling (cytoplasmic sequestering)
is_a: IEV:0000552 ! Regulation of NF-kappaB signaling (cytoplasmic sequestering)
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000554
name: Regulation of PLC gamma signaling
is_a: IEV:0001407 ! Regulation of PLC signaling
is_a: IEV:0001796 ! Regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0000467 ! PLC gamma signaling

[Term]
id: IEV:0000555
name: Positive regulation of PLC gamma signaling (through LAT)
is_a: IEV:0000554 ! Regulation of PLC gamma signaling
is_a: IEV:0001409 ! Positive regulation of PLC signaling
is_a: IEV:0001798 ! Positive regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0000556
name: Regulation of Ras-Raf-MAPK signaling by spred [Drosophila]
is_a: IEV:0000145 ! Regulation pathway

[Term]
id: IEV:0000557
name: Positive regulation of Ras-Raf-MAPK signaling by spred (Drosophila)
is_a: IEV:0000556 ! Regulation of Ras-Raf-MAPK signaling by spred [Drosophila]
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000558
name: Fyn inactivation signaling (through PTP)
xref_analog: PubMed:11781344
xref_analog: PubMed:15034556
is_a: IEV:0001634 ! Fyn inactivation signaling
is_a: IEV:0001888 ! Negative regulation of (Autophosphorylation of Fyn) in Fyn activation signaling
is_a: IEV:0002256 ! Negative regulation of (Fyn activation signaling)

[Term]
id: IEV:0000559
name: Negative regulation of Src family activation signaling
is_a: IEV:0000520 ! Regulation of Src family activation signaling
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000560
name: Positive regulation of Src family activation signaling
is_a: IEV:0000520 ! Regulation of Src family activation signaling
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000561
name: ZAP-70 and CD3 degradation signaling
xref_analog: PubMed:11724969
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
is_a: IEV:0002253 ! Negative regulation of (Phosphorylation of LAT by ZAP-70)
is_a: IEV:0002254 ! Negative regulation of (Phosphorylation of Vav by ZAP-70)

[Term]
id: IEV:0000562
name: Ubiquitination of ZAP-70 by c-Cbl
xref_analog: PubMed:11724969
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000561 ! ZAP-70 and CD3 degradation signaling

[Term]
id: IEV:0000563
name: Ubiquitination of CD3_p by c-Cbl
xref_analog: PubMed:11724969
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000561 ! ZAP-70 and CD3 degradation signaling

[Term]
id: IEV:0000564
name: Proteasome degradation of ZAP-70 by 26 proteasome
xref_analog: PubMed:11724969
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000561 ! ZAP-70 and CD3 degradation signaling

[Term]
id: IEV:0000565
name: Proteasome degradation of CD3 by 26S proteasome
xref_analog: PubMed:11724969
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000561 ! ZAP-70 and CD3 degradation signaling

[Term]
id: IEV:0000566
name: Syk degradation signaling
xref_analog: PubMed:12024036
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
is_a: IEV:0002257 ! Negative regulation of (Phosphorylation of Vav by Syk)

[Term]
id: IEV:0000567
name: Ubiquitination of Syk by c-Cbl
xref_analog: PubMed:12024036
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000566 ! Syk degradation signaling

[Term]
id: IEV:0000568
name: Proteasome degradation of Syk by 26S proteasome
xref_analog: PubMed:12024036
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000566 ! Syk degradation signaling

[Term]
id: IEV:0000569
name: Lck degradation signaling
xref_analog: PubMed:11904433
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
is_a: IEV:0002255 ! Negative regulation of (Lck activation signaling)

[Term]
id: IEV:0000570
name: Ubiquitination of Lck by c-Cbl
xref_analog: PubMed:11904433
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000569 ! Lck degradation signaling

[Term]
id: IEV:0000571
name: Proteasome degradation of Lck by 26S proteasome
xref_analog: PubMed:11904433
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000569 ! Lck degradation signaling

[Term]
id: IEV:0000572
name: Binding of PACAP and PACAP receptor
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000276 ! Heterotrimeric GPCR signaling pathway (through PACAP, G alpha s and adenylate cyclase, cAMP and PKA)

[Term]
id: IEV:0000573
name: Phosphorylation of ZAP-70 by non-receptor tyrosine kinase
xref_analog: PubMed:12040176
xref_analog: PubMed:15343367
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000574
name: Embryonic morphogenesis
def: "The developmental processes by which defined structures within an embryo are generated." [GO:0048598]
xref_analog: GO:0048598
is_a: IEV:0000447 ! Morphogenesis
relationship: part_of IEV:0000397 ! Embryonic development

[Term]
id: IEV:0000575
name: Post-embryonic morphogenesis
def: "Processes aimed at the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GO:0009791]
xref_analog: GO:0009791
is_a: IEV:0000447 ! Morphogenesis
relationship: part_of IEV:0000398 ! Post embryonic development

[Term]
id: IEV:0000576
name: Organ morphogenesis
def: "Morphogenesis of a tissue or tissues that function together to perform a specific function. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GO:0009887]
related_synonym: "histogenesis and organogenesis" [GO:0009887]
xref_analog: GO:0009887
is_a: IEV:0000447 ! Morphogenesis
relationship: part_of IEV:0002712 ! Organ development

[Term]
id: IEV:0000577
name: Flower morphogenesis
def: "The process by which the anatomical structures of the flower are generated and organized. Morphogenesis pertains to the creation of form.\nComment: None" [GO:0048439]
xref_analog: GO:0048439
is_a: IEV:0000141 ! Flower development

[Term]
id: IEV:0000578
name: Tissue regeneration
alt_id: IEV:0000100
def: "The regrowth of lost or destroyed tissues." [GO:0042246]
related_synonym: "Tissue repair" []
xref_analog: GO:0042246
is_a: IEV:0000142 ! Growth
relationship: part_of IEV:0001342 ! Wound healing

[Term]
id: IEV:0000579
name: Binding of extracellular matrix and Integrin complex
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)

[Term]
id: IEV:0000580
name: Binding of extracellular matrix protein and integrin complex
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)

[Term]
id: IEV:0000581
name: Complex formation of integrin complex and caveolin
related_synonym: "Integrin complex and caveolin complex formation" []
is_a: IEV:0002529 ! Complex formation of integrin complex, caveolin, Fyn and Shc
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)

[Term]
id: IEV:0000582
name: Binding of integrin complex and talin
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein

[Term]
id: IEV:0000583
name: Complex formation of integrin-dependent membrane-skeletal protein
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)

[Term]
id: IEV:0000584
name: Binding of integrin complex and FAK
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein

[Term]
id: IEV:0000585
name: Binding of Integrin complex and tensin
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein

[Term]
id: IEV:0000586
name: Binding of FAK and paxillin
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein

[Term]
id: IEV:0000587
name: Binding of FAK and p130Cas
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein

[Term]
id: IEV:0000588
name: Binding of alpha-actinin and F actin
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein

[Term]
id: IEV:0000589
name: Binding of tensin and F actin
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein

[Term]
id: IEV:0000590
name: Binding of vinculin and F actin
xref_analog: PubMed:8632828
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein

[Term]
id: IEV:0000591
name: Binding of talin and F actin
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein

[Term]
id: IEV:0000592
name: Binding of alpha-actinin and zyxin
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein

[Term]
id: IEV:0000593
name: Autophosphorylation of FAK
is_a: IEV:0000481 ! Autophosphorylation in cytosol
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)

[Term]
id: IEV:0000594
name: Phosphorylation of FAK by Src family
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)

[Term]
id: IEV:0000595
name: Phosphorylation of p130Cas by Src family
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)

[Term]
id: IEV:0000596
name: Phosphorylation of paxillin by Src family
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)

[Term]
id: IEV:0000597
name: Binding of FAK and Src family
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein

[Term]
id: IEV:0000598
name: Binding of p130Cas and Crk
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein

[Term]
id: IEV:0000599
name: Binding of FAK and Grb2
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein

[Term]
id: IEV:0000600
name: Binding of Fyn and Shc
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein
relationship: part_of IEV:0002526 ! Complex formation of integrin complex, caveolin-1, Fyn and Shc

[Term]
id: IEV:0000601
name: Phosphorylation of Shc by Fyn
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)

[Term]
id: IEV:0000602
name: Raf activation signaling (through Grb2 and Sos)
related_synonym: "Grb2-Sos-Ras-Raf signaling" []
is_a: IEV:0001258 ! Ras mediated signaling
is_a: IEV:0002072 ! Raf activation signaling
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000865 ! EGF signaling pathway
relationship: part_of IEV:0000866 ! NGF signaling pathway
relationship: part_of IEV:0001257 ! PDGF signaling pathway
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0002626 ! FGF signaling pathway
relationship: part_of IEV:0002627 ! HGF signaling pathway
relationship: part_of IEV:0003328 ! FGF8 signaling pathway(Xenopus)
relationship: part_of IEV:0003329 ! FGF8 signaling pathway(Mouse)

[Term]
id: IEV:0000603
name: Binding of Grb2 and Sos
xref_analog: PubMed:15220003
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000060 ! Grb2-Sos-Ras-PI3K signaling
relationship: part_of IEV:0000602 ! Raf activation signaling (through Grb2 and Sos)
relationship: part_of IEV:0000848 ! RalGDS activation signaling (through Grb2 and Sos)

[Term]
id: IEV:0000604
name: GDP-GTP exchange of Ras by Sos
xref_analog: PubMed:15220003
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0000060 ! Grb2-Sos-Ras-PI3K signaling
relationship: part_of IEV:0000602 ! Raf activation signaling (through Grb2 and Sos)
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000848 ! RalGDS activation signaling (through Grb2 and Sos)

[Term]
id: IEV:0000605
name: GDP-GTP exchange in cytosol
is_a: IEV:0000223 ! GDP-GTP exchange

[Term]
id: IEV:0000606
name: GDP-GTP exchange in unidentified cellular location
is_a: IEV:0000223 ! GDP-GTP exchange

[Term]
id: IEV:0000607
name: Transference in cytosol
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0000608
name: Activation of Raf by Ras-GTP
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000602 ! Raf activation signaling (through Grb2 and Sos)
relationship: part_of IEV:0002199 ! Raf activation signaling (through RasGRP)

[Term]
id: IEV:0000609
name: Binding of Ras-GTP and PI3K
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000060 ! Grb2-Sos-Ras-PI3K signaling

[Term]
id: IEV:0000610
name: Regulation of integrin signaling pathway
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000124 ! Integrin signaling pathway

[Term]
id: IEV:0000611
name: Negative regulation of integrin signaling pathway (through PI3K)
is_a: IEV:0000610 ! Regulation of integrin signaling pathway
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000612
name: Positive regulation of integrin signaling pathway
is_a: IEV:0000610 ! Regulation of integrin signaling pathway
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000613
name: Dephosphorylation of FAK by PTEN
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0000611 ! Negative regulation of integrin signaling pathway (through PI3K)

[Term]
id: IEV:0000614
name: Binding of Shc_p and Grb2
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
relationship: part_of IEV:0000865 ! EGF signaling pathway
relationship: part_of IEV:0000866 ! NGF signaling pathway
relationship: part_of IEV:0001257 ! PDGF signaling pathway
relationship: part_of IEV:0002627 ! HGF signaling pathway

[Term]
id: IEV:0000615
name: Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)
xref_analog: KEGG:hsa04510
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000104 ! Cell migration
relationship: part_of IEV:0000124 ! Integrin signaling pathway
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0001317 ! Cell growth and/or maintenance

[Term]
id: IEV:0000616
name: Integrin signaling pathway (through Rho)
xref_analog: KEGG:hsa04510
xref_analog: KEGG:hsa04810
xref_analog: KEGG:mmu04810
xref_analog: KEGG:rnohsa04810
relationship: part_of IEV:0000091 ! Cell growth
relationship: part_of IEV:0000095 ! Stress fiber formation
relationship: part_of IEV:0000104 ! Cell migration
relationship: part_of IEV:0000105 ! Cell adhesion
relationship: part_of IEV:0000124 ! Integrin signaling pathway
relationship: part_of IEV:0000578 ! Tissue regeneration
relationship: part_of IEV:0000637 ! Actin polymerization and/or depolymerization
relationship: part_of IEV:0001199 ! Actomyosin structure organization and biogenesis

[Term]
id: IEV:0000617
name: Phosphorylation of ERK by FAK
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)

[Term]
id: IEV:0000618
name: Integrin signaling pathway (through Rac, Rap1 and JNK cascade)
xref_analog: KEGG:hsa04510
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0000124 ! Integrin signaling pathway
relationship: part_of IEV:0001317 ! Cell growth and/or maintenance

[Term]
id: IEV:0000619
name: Activation of MLCK by ERK_p
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000127 ! Integrin signaling pathway (through ERK cascade)

[Term]
id: IEV:0000620
name: Binding of integrin complex and Ilk
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein

[Term]
id: IEV:0000621
name: Binding of FAK and PI3K
def: "PI3K approaching to the plasma membrane" [XX:<new dbxref>]
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000615 ! Integrin signaling pathway (through PI3K-AKT (PKB)-Bad signaling)

[Term]
id: IEV:0000622
name: Binding of PIP3 and AKT
is_a: IEV:0000013 ! Binding in cytosol
is_a: IEV:0000174 ! Binding outside the mitochondria membrane
relationship: part_of IEV:0001484 ! AKT(PKB) activation signaling

[Term]
id: IEV:0000623
name: Phosphorylation of AKT by IlK
is_a: IEV:0002415 ! Phosphorylation of Akt by protein kinase

[Term]
id: IEV:0000624
name: Phosphorylation outside the mitochondria membrane
is_a: IEV:0000025 ! Phosphorylation in cytosol

[Term]
id: IEV:0000625
name: Binding of PIP3 and PDK1
is_a: IEV:0000013 ! Binding in cytosol
is_a: IEV:0000174 ! Binding outside the mitochondria membrane
relationship: part_of IEV:0001484 ! AKT(PKB) activation signaling

[Term]
id: IEV:0000626
name: Phosphorylation of Vav by Syk
xref_analog: PubMed:9843681
is_a: IEV:0000264 ! Phosphorylation of Vav by non-receptor tyrosine kinase
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0000627
name: GDP-GTP exchange of Rac by Vav
xref_analog: PubMed:12818159
xref_analog: PubMed:15343367
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)

[Term]
id: IEV:0000628
name: Activation of PAK by Rac
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)
relationship: part_of IEV:0000659 ! Rac/Cdc42-PAK-MLCK signaling

[Term]
id: IEV:0000629
name: Phosphorylation of MAPKKK by PAK
is_a: IEV:0000633 ! Phosphorylation of MAPKKK by MAPKKKK
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)

[Term]
id: IEV:0000630
name: Binding of Crk and C3G
xref_analog: PubMed:11804588
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)
relationship: part_of IEV:0002081 ! Rap1 activation signaling (through cAMP, PKA, Cbl and C3G)
relationship: part_of IEV:0002627 ! HGF signaling pathway

[Term]
id: IEV:0000631
name: GDP-GTP exchange of Rap1 by C3G
xref_analog: PubMed:9560161
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)
relationship: part_of IEV:0002081 ! Rap1 activation signaling (through cAMP, PKA, Cbl and C3G)
relationship: part_of IEV:0002627 ! HGF signaling pathway

[Term]
id: IEV:0000632
name: Activation of MAPKKKK by Rap1
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)

[Term]
id: IEV:0000633
name: Phosphorylation of MAPKKK by MAPKKKK
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase." [GO:0000185]
related_synonym: "activation of MAP kinase kinase kinase" []
related_synonym: "activation of MAPKKK activity" []
xref_analog: GO:0000185
xref_analog: GO:0042655
is_a: IEV:0002086 ! Phosphorylation of MAPKKK by non-receptor serine/threonine kinase
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)

[Term]
id: IEV:0000634
name: GDP-GTP exchange of Rac by Dock180
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)
relationship: part_of IEV:0002627 ! HGF signaling pathway

[Term]
id: IEV:0000635
name: Complex formation of RhoG, Elmo and Dock180
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000618 ! Integrin signaling pathway (through Rac, Rap1 and JNK cascade)

[Term]
id: IEV:0000636
name: Binding of PIP2 and gelsolin
is_a: IEV:0000534 ! Binding of PIP2 and actin-binding protein

[Term]
id: IEV:0000637
name: Actin polymerization and/or depolymerization
def: "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GO:0008154]
xref_analog: GO:0008154
is_a: IEV:0000092 ! Cytoskeleton organization and biogenesis

[Term]
id: IEV:0000638
name: Actin filament depolymerization
def: "Disassembly of actin filaments by the removal of actin monomers from a filament." [GO:0030042]
related_synonym: "Actin depolymerization" []
xref_analog: GO:0030042
is_a: IEV:0000637 ! Actin polymerization and/or depolymerization

[Term]
id: IEV:0000639
name: Actin filament polymerization
def: "Assembly of actin filaments by the addition of actin monomers to a filament." [GO:0030041]
related_synonym: "Actin polymerization" []
xref_analog: GO:0030041
is_a: IEV:0000637 ! Actin polymerization and/or depolymerization

[Term]
id: IEV:0000640
name: Binding of PIP2 and profilin
is_a: IEV:0000534 ! Binding of PIP2 and actin-binding protein

[Term]
id: IEV:0000641
name: Binding of PIP2 and cofilin
is_a: IEV:0000534 ! Binding of PIP2 and actin-binding protein

[Term]
id: IEV:0000642
name: Binding of PIP2 and actinin
is_a: IEV:0000534 ! Binding of PIP2 and actin-binding protein

[Term]
id: IEV:0000643
name: Binding of PIP2 and vinculin
xref_analog: PubMed:8632828
is_a: IEV:0000534 ! Binding of PIP2 and actin-binding protein

[Term]
id: IEV:0000644
name: Binding of vinculin and talin
xref_analog: PubMed:8632828
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000583 ! Complex formation of integrin-dependent membrane-skeletal protein

[Term]
id: IEV:0000645
name: Binding of PIP2 and ERM
is_a: IEV:0000534 ! Binding of PIP2 and actin-binding protein

[Term]
id: IEV:0000646
name: Activation of ERM by PIP2
xref_analog: PubMed:12045227
xref_analog: PubMed:8858161
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000647
name: Activation of PI5K by Rho
xref_analog: PubMed:7954816
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0001262 ! Rho-PI5K signaling

[Term]
id: IEV:0000648
name: Y-27632 medication
def: "Inhibitor of p160ROCK" [XX:<new dbxref>]
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0000649
name: Activation of p160ROCK by Rho
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0001261 ! Rho-p160-myosin phosphatase signaling

[Term]
id: IEV:0000650
name: Phosphorylation of myosin phosphatase by p160ROCK
def: "Inactivation of myosin phosphatase" [XX:<new dbxref>]
xref_analog: PubMed:8662509
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001261 ! Rho-p160-myosin phosphatase signaling

[Term]
id: IEV:0000651
name: Phosphorylation of MLC by MLCK
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000652
name: Phosphorylation of LIM-kinase by p160ROCK
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000653
name: Phosphorylation of cofilin by LIM-kinase
xref_analog: PubMed:9655398
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000654
name: Phosphorylation of MLCK by ERK
xref_analog: PubMed:9128257
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000655
name: Regulation of Integrin signaling pathway (through Rho)
is_a: IEV:0000610 ! Regulation of integrin signaling pathway
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000656
name: Negative regulation of Integrin signaling pathway (through Rho)
is_a: IEV:0000611 ! Negative regulation of integrin signaling pathway (through PI3K)
is_a: IEV:0000655 ! Regulation of Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000657
name: Positive regulation of Integrin signaling pathway (through Rho)
is_a: IEV:0000612 ! Positive regulation of integrin signaling pathway
is_a: IEV:0000655 ! Regulation of Integrin signaling pathway (through Rho)

[Term]
id: IEV:0000658
name: Phosphorylation of MLCK by PAK
xref_analog: PubMed:10092231
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000659 ! Rac/Cdc42-PAK-MLCK signaling

[Term]
id: IEV:0000659
name: Rac/Cdc42-PAK-MLCK signaling
xref_analog: KEGG:hsa04510
xref_analog: KEGG:hsa04810
xref_analog: KEGG:mmu04810
xref_analog: KEGG:rno04810
is_a: IEV:0000656 ! Negative regulation of Integrin signaling pathway (through Rho)
is_a: IEV:0001259 ! Rac mediated signaling
relationship: part_of IEV:0000095 ! Stress fiber formation

[Term]
id: IEV:0000660
name: Activation of PAK by Cdc42
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000659 ! Rac/Cdc42-PAK-MLCK signaling

[Term]
id: IEV:0000661
name: GPCR signaling pathway
def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GO:0007186]
related_synonym: "G-protein coupled receptor protein signaling pathway" []
xref_analog: GO:0007186
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000662
name: Binding of GPCR ligand and GPCR
xref_analog: PubMed:14734786
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000661 ! GPCR signaling pathway
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)

[Term]
id: IEV:0000663
name: GDP-GTP exchange of G alpha
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0002012 ! G alpha GDP-GTP exchange signaling

[Term]
id: IEV:0000664
name: Dissociation of G alpha-GTP and G beta:G gamma
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0000665
name: Dissociation in plasma membrane
is_a: IEV:0000006 ! Dissociation

[Term]
id: IEV:0000666
name: Binding of G alpha-GTP and effector
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0000667
name: Binding of G beta gamma and effector
xref_analog: PubMed:14734786
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000661 ! GPCR signaling pathway
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)
relationship: part_of IEV:0000692 ! Heterotrimeric GPCR signaling pathway (through G alpha i)
relationship: part_of IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)

[Term]
id: IEV:0000668
name: Regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0000669
name: Negative regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000668 ! Regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000670
name: Positive regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000668 ! Regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000671
name: G alpha-GTP hydrolysis signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling
is_a: IEV:0000669 ! Negative regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000672
name: Hydrolysis of GTP by G alpha-GTP
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000671 ! G alpha-GTP hydrolysis signaling
relationship: part_of IEV:0002059 ! Negative regulation of (GDP-GTP exchange of G alpha)

[Term]
id: IEV:0000673
name: Hydrolysis in unidentified cellular location
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0000674
name: Binding of G alpha-GTP and RGS
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000671 ! G alpha-GTP hydrolysis signaling

[Term]
id: IEV:0000675
name: Dissociation of G alpha-GDP and target protein
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000671 ! G alpha-GTP hydrolysis signaling

[Term]
id: IEV:0000676
name: Small GTPase mediated signaling
def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GO:0007264]
related_synonym: "small GTPase mediated signal transduction" [GO:0007264]
xref_analog: GO:0007264
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000677
name: GDP-GTP exchange of small GTPase by GEF
is_obsolete: true

[Term]
id: IEV:0000678
name: Binding of small GTPase-GTP and target protein
is_obsolete: true

[Term]
id: IEV:0000679
name: Binding of small GTPase-GTP and GAP
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000684 ! Small GTPase hydrolysis signaling

[Term]
id: IEV:0000680
name: Hydrolysis of GTP by small GTPase
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000684 ! Small GTPase hydrolysis signaling

[Term]
id: IEV:0000681
name: Regulation of small GTPase mediated signaling
def: "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GO:0051056]
related_synonym: "regulation of small GTPase mediated signal transduction" [GO:0051056]
xref_analog: GO:0051056
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000676 ! Small GTPase mediated signaling

[Term]
id: IEV:0000682
name: Positive regulation of small GTPase mediated signaling
def: "Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction." [GO:0051057]
related_synonym: "positive regulation of small GTPase mediated signal transduction" [GO:0051057]
xref_analog: GO:0051057
is_a: IEV:0000681 ! Regulation of small GTPase mediated signaling
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000683
name: Negative regulation of small GTPase mediated signaling
def: "Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase mediated signal transduction." [GO:0051058]
related_synonym: "negative regulation of small GTPase mediated signal transduction" [GO:0051058]
xref_analog: GO:0051058
is_a: IEV:0000681 ! Regulation of small GTPase mediated signaling
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000684
name: Small GTPase hydrolysis signaling
is_a: IEV:0000683 ! Negative regulation of small GTPase mediated signaling
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000685
name: Hydrolysis in cytosol
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0000686
name: Binding of G alpha s-GTP and adenylate cyclase
comment: Inactivation of ACs
xref_analog: PubMed:14734786
is_a: IEV:0001992 ! Binding of G alpha s-GTP and effector
relationship: part_of IEV:0000276 ! Heterotrimeric GPCR signaling pathway (through PACAP, G alpha s and adenylate cyclase, cAMP and PKA)
relationship: part_of IEV:0002020 ! Negative regulation of (Binding of G alpha i-GTP and adenylate cyclase)
relationship: part_of IEV:0002021 ! Adenylate cyclase activation signaling
relationship: part_of IEV:0002028 ! cAMP concentration elevation

[Term]
id: IEV:0000687
name: Hydrolysis of ATP to cAMP by adenylate cyclase
def: "The formation from simpler components of cyclic AMP, adenosine 3',5'-phosphate." [GO:0006171]
xref_analog: GO:0006171
xref_analog: PubMed:7814360
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000780 ! PKA activation signaling
relationship: part_of IEV:0002028 ! cAMP concentration elevation

[Term]
id: IEV:0000688
name: Dissociation of G alpha s-GDP and adenylate cyclase
xref_analog: PubMed:11604548
is_a: IEV:0000675 ! Dissociation of G alpha-GDP and target protein
relationship: part_of IEV:0000702 ! G alpha s-GTP hydrolysis signaling

[Term]
id: IEV:0000689
name: Binding of G alpha i-GTP and adenylate cyclase
xref_analog: PubMed:14734786
is_a: IEV:0001997 ! Binding of G alpha i-GTP and effector
relationship: part_of IEV:0002002 ! Negative regulation of (Binding of G alpha s-GTP and adenylate cyclase)
relationship: part_of IEV:0002022 ! Adenylate cyclase inactivation signaling

[Term]
id: IEV:0000690
name: Dissociation of G alpha i-GDP and adenylate cyclase
is_a: IEV:0000675 ! Dissociation of G alpha-GDP and target protein

[Term]
id: IEV:0000691
name: Heterotrimeric GPCR signaling pathway (through G alpha s)
xref_analog: GO:0007189
xref_analog: PubMed:14734786
is_a: IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0000692
name: Heterotrimeric GPCR signaling pathway (through G alpha i)
alt_id: IEV:0000716
related_synonym: "Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin)" []
is_a: IEV:0000661 ! GPCR signaling pathway
relationship: part_of IEV:0000717 ! Whooping cough

[Term]
id: IEV:0000693
name: Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
is_a: IEV:0000669 ! Negative regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000731 ! Regulation of heterotrimeric GPCR signaling pathway (through G alpha s)

[Term]
id: IEV:0000694
name: Negative regulation of (G alpha i GDP-GTP exchange signaling)
is_a: IEV:0000669 ! Negative regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0002026 ! Negative regulation of heteromeric GPCR signaling pathway (through G alpha i)

[Term]
id: IEV:0000695
name: Positive regulation of heterotrimeric GPCR signaling pathway (through G alpha i)
is_a: IEV:0000670 ! Positive regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000730 ! Regulation of heterotrimeric GPCR signaling pathway (through G alpha i)

[Term]
id: IEV:0000696
name: Positive regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
is_a: IEV:0000670 ! Positive regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000731 ! Regulation of heterotrimeric GPCR signaling pathway (through G alpha s)

[Term]
id: IEV:0000697
name: Binding of G alpha i-GTP and RGS
xref_analog: PubMed:8774883
is_a: IEV:0000674 ! Binding of G alpha-GTP and RGS
relationship: part_of IEV:0000701 ! G alpha i-GTP hydrolysis signaling

[Term]
id: IEV:0000698
name: Hydrolysis of GTP by G alpha i-GTP and RGS
xref_analog: PubMed:8774883
is_a: IEV:0000672 ! Hydrolysis of GTP by G alpha-GTP
relationship: part_of IEV:0000701 ! G alpha i-GTP hydrolysis signaling
relationship: part_of IEV:0002060 ! Negative regulation of (GDP-GTP exchange of G alpha i)

[Term]
id: IEV:0000699
name: Binding of G alpha s-GTP and RGS
xref_analog: PubMed:11604548
is_a: IEV:0000674 ! Binding of G alpha-GTP and RGS
relationship: part_of IEV:0000702 ! G alpha s-GTP hydrolysis signaling

[Term]
id: IEV:0000700
name: Hydrolysis of GTP by G alpha s-GTP and RGS
xref_analog: PubMed:11604548
is_a: IEV:0000672 ! Hydrolysis of GTP by G alpha-GTP
relationship: part_of IEV:0000702 ! G alpha s-GTP hydrolysis signaling
relationship: part_of IEV:0002062 ! Negative regulation of (GDP-GTP exchange of G alpha s)

[Term]
id: IEV:0000701
name: G alpha i-GTP hydrolysis signaling
xref_analog: PubMed:8774883
is_a: IEV:0000671 ! G alpha-GTP hydrolysis signaling

[Term]
id: IEV:0000702
name: G alpha s-GTP hydrolysis signaling
related_synonym: "G alpha s inactivation signaling" []
xref_analog: PubMed:11604548
is_a: IEV:0000671 ! G alpha-GTP hydrolysis signaling
relationship: part_of IEV:0000694 ! Negative regulation of (G alpha i GDP-GTP exchange signaling)
relationship: part_of IEV:0002004 ! Negative regulation of (G alpha s GDP-GTP exchange signaling)

[Term]
id: IEV:0000703
name: Ras-GTP hydrolysis signaling
is_a: IEV:0000684 ! Small GTPase hydrolysis signaling
is_a: IEV:0000704 ! Negative regulation of Ras mediated signaling
is_a: IEV:0000822 ! Negative regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
is_a: IEV:0000840 ! Negative regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
is_a: IEV:0000854 ! Negative regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
is_a: IEV:0000861 ! Negative regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000704
name: Negative regulation of Ras mediated signaling
def: "Any process that stops, prevents or reduces the rate, frequency or extent of Ras protein signal transduction." [GO:0046580]
related_synonym: "negative regulation of Ras protein signal transduction" [GO:0046580]
xref_analog: GO:0046580
is_a: IEV:0000683 ! Negative regulation of small GTPase mediated signaling
is_a: IEV:0001401 ! Regulation of Ras mediated signaling

[Term]
id: IEV:0000705
name: Hydrolysis of GTP by Ras
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000703 ! Ras-GTP hydrolysis signaling

[Term]
id: IEV:0000706
name: Binding of small Ras-GTP and GAP
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000703 ! Ras-GTP hydrolysis signaling

[Term]
id: IEV:0000707
name: Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
is_a: IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)
relationship: part_of IEV:0000715 ! Diarrhea

[Term]
id: IEV:0000708
name: ADP-ribosylation of G alpha s by cholera toxin
is_a: IEV:0000710 ! ADP ribosylation in cytosol
relationship: part_of IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)

[Term]
id: IEV:0000709
name: ADP ribosylation
def: "Reaction that can affect Arg, Cys, Glu, Arg and Asn residues." [MI:0557]
xref_analog: EC:2.4.5.30
xref_analog: EC:2.4.5.31
xref_analog: EC:2.4.5.36
xref_analog: EC:2.4.5.37
xref_analog: MI:0557
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0000710
name: ADP ribosylation in cytosol
is_a: IEV:0000709 ! ADP ribosylation

[Term]
id: IEV:0000711
name: ADP ribosylation in plasma membrane
is_a: IEV:0000709 ! ADP ribosylation

[Term]
id: IEV:0000712
name: Transference in unidentified cellular location
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0000713
name: Binding of G alpha s-GTP-ADPrib and adenylate cyclase
is_a: IEV:0000686 ! Binding of G alpha s-GTP and adenylate cyclase
relationship: part_of IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
relationship: part_of IEV:0002066 ! Negative regulation of (Hydrolysis of GTP by G alpha s-GTP and RGS) (through Adenylate cyclase activation signaling)

[Term]
id: IEV:0000714
name: Clinical presentation
is_a: IEV:0000075 ! Disease

[Term]
id: IEV:0000715
name: Diarrhea
def: "An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight." [MeSH:D003967]
xref_analog: MeSH:D003967
is_a: IEV:0000714 ! Clinical presentation

[Term]
id: IEV:0000717
name: Whooping cough
def: "A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath." [MeSH:D014917]
xref_analog: MeSH:D014917
is_a: IEV:0000075 ! Disease

[Term]
id: IEV:0000718
name: ADP ribosylation of G alpha i by pertussis toxin
xref_analog: PubMed:9032437
is_a: IEV:0000710 ! ADP ribosylation in cytosol
relationship: part_of IEV:0002030 ! Negative regulation of (Binding of GPCR ligand and GPCR)

[Term]
id: IEV:0000719
name: Dissociation of G alpha i-GTP and G beta:G gamma
is_a: IEV:0000664 ! Dissociation of G alpha-GTP and G beta:G gamma
relationship: part_of IEV:0000692 ! Heterotrimeric GPCR signaling pathway (through G alpha i)
relationship: part_of IEV:0000701 ! G alpha i-GTP hydrolysis signaling

[Term]
id: IEV:0000720
name: GDP-GTP exchange of G alpha i
xref_analog: PubMed:14734786
is_a: IEV:0000663 ! GDP-GTP exchange of G alpha
relationship: part_of IEV:0002017 ! G alpha i GDP-GTP exchange signaling
relationship: part_of IEV:0002034 ! Negative regulation of (Hydrolysis of GTP by G alpha i-GTP and RGS)

[Term]
id: IEV:0000721
name: Dissociation of G alpha s-GTP and G beta:G gamma
xref_analog: PubMed:14734786
is_a: IEV:0000664 ! Dissociation of G alpha-GTP and G beta:G gamma
relationship: part_of IEV:0000276 ! Heterotrimeric GPCR signaling pathway (through PACAP, G alpha s and adenylate cyclase, cAMP and PKA)
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)
relationship: part_of IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)

[Term]
id: IEV:0000722
name: GDP-GTP exchange of G alpha s
xref_analog: PubMed:14734786
is_a: IEV:0000663 ! GDP-GTP exchange of G alpha
relationship: part_of IEV:0000276 ! Heterotrimeric GPCR signaling pathway (through PACAP, G alpha s and adenylate cyclase, cAMP and PKA)
relationship: part_of IEV:0002003 ! G alpha s GDP-GTP exchange signaling
relationship: part_of IEV:0002011 ! Negative regulation of (Hydrolysis of GTP by G alpha s-GTP and RGS) (through G alpha s GDP-GTP exchange signaling)

[Term]
id: IEV:0000723
name: Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)
alt_id: IEV:0000121
def: "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon." [GO:0016056]
related_synonym: "rhodopsin mediated signaling" []
related_synonym: "Visual Signal Transduction" []
xref_analog: GO:0016056
xref_analog: GO:0030265
is_a: IEV:0002636 ! Heterotrimeric GPCR signaling pathway (through G alpha t)

[Term]
id: IEV:0000724
name: Activation of rhodopsin by photon
is_a: IEV:0000725 ! Activation in extracellular
relationship: part_of IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)

[Term]
id: IEV:0000725
name: Activation in extracellular
is_a: IEV:0000008 ! Unknown activation

[Term]
id: IEV:0000726
name: GDP-GTP exchange of G alpha t
xref_analog: PubMed:14734786
is_a: IEV:0000663 ! GDP-GTP exchange of G alpha
relationship: part_of IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)
relationship: part_of IEV:0002042 ! Negative regulation of (Hydrolysis of GTP by G alpha t-GTP and RGS)
relationship: part_of IEV:0002043 ! G alpha t GDP-GTP exchange signaling

[Term]
id: IEV:0000727
name: Dissociation of G alpha t-GTP and G beta:G gamma
is_a: IEV:0000664 ! Dissociation of G alpha-GTP and G beta:G gamma
relationship: part_of IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)

[Term]
id: IEV:0000728
name: Binding of G alpha t-GTP and cGMP PDE
is_a: IEV:0002013 ! Binding of G alpha t-GTP and effector
relationship: part_of IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)

[Term]
id: IEV:0000729
name: Hydrolysis of cGMP to GMP by cGMP PDE
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)

[Term]
id: IEV:0000730
name: Regulation of heterotrimeric GPCR signaling pathway (through G alpha i)
is_a: IEV:0000668 ! Regulation of heterotrimeric GPCR signaling pathway
relationship: part_of IEV:0000692 ! Heterotrimeric GPCR signaling pathway (through G alpha i)

[Term]
id: IEV:0000731
name: Regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
is_a: IEV:0000668 ! Regulation of heterotrimeric GPCR signaling pathway
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)

[Term]
id: IEV:0000732
name: Regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)
is_a: IEV:0000668 ! Regulation of heterotrimeric GPCR signaling pathway
relationship: part_of IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)

[Term]
id: IEV:0000733
name: Negative regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)
is_a: IEV:0000669 ! Negative regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000732 ! Regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)

[Term]
id: IEV:0000734
name: Positive regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)
is_a: IEV:0000670 ! Positive regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000732 ! Regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)

[Term]
id: IEV:0000735
name: G alpha t-GTP hydrolysis signaling
is_a: IEV:0000671 ! G alpha-GTP hydrolysis signaling
is_a: IEV:0000733 ! Negative regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)

[Term]
id: IEV:0000736
name: Binding of G alpha t-GTP and RGS
is_a: IEV:0000674 ! Binding of G alpha-GTP and RGS
relationship: part_of IEV:0000735 ! G alpha t-GTP hydrolysis signaling

[Term]
id: IEV:0000737
name: Dissociation of G alpha t-GDP and cGMP PDE
is_a: IEV:0000675 ! Dissociation of G alpha-GDP and target protein
relationship: part_of IEV:0000735 ! G alpha t-GTP hydrolysis signaling

[Term]
id: IEV:0000738
name: Hydrolysis of GTP by G alpha t-GTP and RGS
is_a: IEV:0000672 ! Hydrolysis of GTP by G alpha-GTP
relationship: part_of IEV:0000735 ! G alpha t-GTP hydrolysis signaling
relationship: part_of IEV:0002063 ! Negative regulation of (GDP-GTP exchange of G alpha t)

[Term]
id: IEV:0000739
name: Ion transport through ion channel
def: "The directed movement of charged atoms or small charged molecules into, out of, within or between cells. " [GO:0006811]
related_synonym: "ion transport" []
xref_analog: GO:0006811
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000740
name: Cation ion transport from extracellular to cytosol  through cation channel
is_a: IEV:0000733 ! Negative regulation of heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and PDE)
is_a: IEV:0000739 ! Ion transport through ion channel
is_a: IEV:0001943 ! Translocation from ER to cytosol
relationship: part_of IEV:0000759 ! Rod dark adaptation signaling

[Term]
id: IEV:0000741
name: GDP-GTP exchange of G alpha q
xref_analog: PubMed:14734786
is_a: IEV:0000663 ! GDP-GTP exchange of G alpha
relationship: part_of IEV:0002031 ! G alpha q GDP-GTP exchange signaling
relationship: part_of IEV:0002037 ! Negative regulation of (Hydrolysis of GTP by G alpha q-GTP and RGS)

[Term]
id: IEV:0000742
name: Visual perception
def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GO:0007601]
xref_analog: GO:0007601
is_a: IEV:0000744 ! Neurological process

[Term]
id: IEV:0000743
name: Changes in polarization state of photoreceptor cell membrane
def: "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon." [GO:0016057]
xref_analog: GO:0016057
is_a: IEV:0001239 ! Changes in polarization state of the membrane

[Term]
id: IEV:0000744
name: Neurological process
def: "The processes pertaining to the functions of the nervous system of an organism." [GO:0050877]
related_synonym: "Neurophysiological process" [GO:0050877]
xref_analog: GO:0050877
is_a: IEV:0001327 ! Multicellular organismal process

[Term]
id: IEV:0000745
name: Neurotransmitter secretion
def: "The regulated release of neurotransmitter into the synaptic cleft." [GO:0007269]
xref_analog: GO:0007269
is_a: IEV:0000744 ! Neurological process

[Term]
id: IEV:0000746
name: Adaptation of rhodopsin mediated signaling
def: "Process by which the visual system can modulate its sensitivity and response to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation." [GO:0016062]
xref_analog: GO:0016062
is_a: IEV:0000744 ! Neurological process

[Term]
id: IEV:0000747
name: Deactivation of rhodopsin mediated signaling
def: "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [GO:0016059]
xref_analog: GO:0016059
is_a: IEV:0000744 ! Neurological process

[Term]
id: IEV:0000748
name: Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
xref_analog: GO:0007200
is_a: IEV:0002634 ! Heterotrimeric GPCR signaling pathway (through G alpha q)

[Term]
id: IEV:0000749
name: Dissociation of G alpha q-GTP and G beta:G gamma
xref_analog: GO:0007201
is_a: IEV:0000664 ! Dissociation of G alpha-GTP and G beta:G gamma
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)

[Term]
id: IEV:0000750
name: Binding of G alpha q-GTP and PLC beta
xref_analog: PubMed:14734786
is_a: IEV:0002403 ! Binding of G alpha q-GTP and PLC
relationship: part_of IEV:0000065 ! PLC beta signaling

[Term]
id: IEV:0000751
name: Regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
is_a: IEV:0000668 ! Regulation of heterotrimeric GPCR signaling pathway
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)

[Term]
id: IEV:0000752
name: Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
is_a: IEV:0000669 ! Negative regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000751 ! Regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)

[Term]
id: IEV:0000753
name: Positive regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
is_a: IEV:0000670 ! Positive regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000751 ! Regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)

[Term]
id: IEV:0000754
name: G alpha q-GTP hydrolysis signaling
is_a: IEV:0000671 ! G alpha-GTP hydrolysis signaling
is_a: IEV:0000752 ! Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)

[Term]
id: IEV:0000755
name: Binding of G alpha q-GTP and RGS
is_a: IEV:0000674 ! Binding of G alpha-GTP and RGS
relationship: part_of IEV:0000754 ! G alpha q-GTP hydrolysis signaling

[Term]
id: IEV:0000756
name: Dissociation of G alpha q-GDP and PLC beta
is_a: IEV:0000675 ! Dissociation of G alpha-GDP and target protein
relationship: part_of IEV:0000754 ! G alpha q-GTP hydrolysis signaling

[Term]
id: IEV:0000757
name: Hydrolysis of GTP by G alpha q-GTP and RGS
is_a: IEV:0000672 ! Hydrolysis of GTP by G alpha-GTP
relationship: part_of IEV:0000754 ! G alpha q-GTP hydrolysis signaling
relationship: part_of IEV:0002061 ! Negative regulation of (GDP-GTP exchange of G alpha q)

[Term]
id: IEV:0000758
name: Rod dark adaptation
is_a: IEV:0000744 ! Neurological process

[Term]
id: IEV:0000759
name: Rod dark adaptation signaling
is_a: IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0000760
name: Inactivation of Rhodopsin
is_a: IEV:0000245 ! Inactivation in extracellular
relationship: part_of IEV:0000759 ! Rod dark adaptation signaling

[Term]
id: IEV:0000761
name: Nuclear import of Notch (NIC) from the cytosol
xref_analog: PubMed:14985712
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001171 ! Nuclear import of Notch (NIC) from the plasma membrane

[Term]
id: IEV:0000762
name: Channel opening/closing in the plasma membrane
is_a: IEV:0000767 ! Channel opening/closing

[Term]
id: IEV:0000763
name: Binding of cGMP and cGMP activated cation ion channel and the channel opening
is_a: IEV:0000013 ! Binding in cytosol
is_a: IEV:0000762 ! Channel opening/closing in the plasma membrane
relationship: part_of IEV:0000759 ! Rod dark adaptation signaling

[Term]
id: IEV:0000764
name: Dissociation of cGMP and cGMP activated cation ion channel and the channel closing
is_a: IEV:0000023 ! Dissociation in cytosol
is_a: IEV:0000762 ! Channel opening/closing in the plasma membrane
relationship: part_of IEV:0001249 ! Cytosolic cation ion concentration decline (through cGMP activated cation ion channel)

[Term]
id: IEV:0000765
name: Dissociation of IP3 and IP3R and IP3R closing
is_a: IEV:0000770 ! Channel opening/closing in the ER membrane
is_a: IEV:0001032 ! Dissociation outside the ER membrane

[Term]
id: IEV:0000766
name: Binding of G alpha t-GDP and G beta:G gamma
is_a: IEV:0001981 ! Binding of G alpha and G beta:G gamma
relationship: part_of IEV:0000759 ! Rod dark adaptation signaling

[Term]
id: IEV:0000767
name: Channel opening/closing
is_a: IEV:0000071 ! Molecular event

[Term]
id: IEV:0000768
name: Hyper polarization state of photoreceptor cell membrane
is_a: IEV:0000743 ! Changes in polarization state of photoreceptor cell membrane
relationship: part_of IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)

[Term]
id: IEV:0000769
name: Depolarization state of photoreceptor cell membrane
is_a: IEV:0000743 ! Changes in polarization state of photoreceptor cell membrane
relationship: part_of IEV:0000759 ! Rod dark adaptation signaling

[Term]
id: IEV:0000770
name: Channel opening/closing in the ER membrane
is_a: IEV:0000767 ! Channel opening/closing

[Term]
id: IEV:0000771
name: Change in material concentration
is_a: IEV:0000071 ! Molecular event

[Term]
id: IEV:0000772
name: Cytosolic calcium ion concentration elevation (through IP3 receptor)
def: "Any process that increases the concentration of calcium ions in the cytosol during the process of G-protein signaling coupled to IP3 second messenger." [GO:0051482]
related_synonym: "elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" []
related_synonym: "elevation of cytosolic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" []
xref_analog: GO:0051482
is_a: IEV:0001246 ! Cytosolic calcium ion concentration elevation
relationship: part_of IEV:0000065 ! PLC beta signaling
relationship: part_of IEV:0000467 ! PLC gamma signaling
relationship: part_of IEV:0000471 ! PLC signaling
relationship: part_of IEV:0000759 ! Rod dark adaptation signaling
relationship: part_of IEV:0002632 ! VEGF signaling pathway

[Term]
id: IEV:0000773
name: Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o and PLCbeta)
is_a: IEV:0002635 ! Heterotrimeric GPCR signaling pathway (through G alpha o)

[Term]
id: IEV:0000774
name: Circadian rhythm
alt_id: IEV:0001334
def: "The specific actions or reactions of an organism that recur with a regularity of approximately 24 hours." [GO:0007623]
related_synonym: "Response to circadian rhythm" []
xref_analog: GO:0007623
xref_analog: GO:0050895
xref_analog: KEGG:hsa04710
xref_analog: KEGG:mmu04710
xref_analog: KEGG:rno04710
is_a: IEV:0001328 ! Rhythmic behavior

[Term]
id: IEV:0000775
name: Binding of melatonin and melatonin receptor
comment: @part_of@ Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o, PLCbeta and circadian rhythm)
xref_analog: GO:0001664
xref_analog: GO:0008502
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000773 ! Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o and PLCbeta)

[Term]
id: IEV:0000776
name: GDP-GTP exchange of G alpha o
xref_analog: PubMed:14734786
is_a: IEV:0000663 ! GDP-GTP exchange of G alpha
relationship: part_of IEV:0000773 ! Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o and PLCbeta)

[Term]
id: IEV:0000777
name: Dissociation of G alpha o-GTP and G beta:G gamma
is_a: IEV:0000664 ! Dissociation of G alpha-GTP and G beta:G gamma
relationship: part_of IEV:0000773 ! Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o and PLCbeta)

[Term]
id: IEV:0000778
name: Binding of G alpha o-GTP and PLC beta
xref_analog: PubMed:14734786
is_a: IEV:0001998 ! Binding of G alpha o-GTP and effector

[Term]
id: IEV:0000779
name: PKC activation signaling
def: "The series of molecular signals that results in the upregulation of protein kinase C activity in response to the signal." [GO:0007205]
related_synonym: "PKC activation" [GO:0007205]
related_synonym: "protein kinase C activation" [GO:0007205]
xref_analog: GO:0007205
is_a: IEV:0000458 ! Protein activation/inactivation signaling
is_a: IEV:0001302 ! Calcium ion dependent protein activation signaling
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
relationship: part_of IEV:0000773 ! Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o and PLCbeta)
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0002633 ! Heterotrimeric GPCR signaling pathway (through Angiotensin and G alpha q)
relationship: part_of IEV:0002653 ! Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)

[Term]
id: IEV:0000780
name: PKA activation signaling
xref_analog: PubMed:14734786
is_a: IEV:0000458 ! Protein activation/inactivation signaling
is_a: IEV:0001988 ! cAMP mediated signaling
relationship: part_of IEV:0000055 ! PKA-Bad signaling
relationship: part_of IEV:0000276 ! Heterotrimeric GPCR signaling pathway (through PACAP, G alpha s and adenylate cyclase, cAMP and PKA)
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)
relationship: part_of IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
relationship: part_of IEV:0002637 ! Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)

[Term]
id: IEV:0000782
name: Phosphorylation of IKK complex by MEKK3
def: "TNFR1 signaling" [XX:<new dbxref>]
xref_analog: GO:0007250
is_a: IEV:0000250 ! Phosphorylation of IKK complex by MAPKKK

[Term]
id: IEV:0000783
name: Gene expression by NF-kappaB
is_a: IEV:0000182 ! Gene expression
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000784
name: Phosphorylation of IKK complex by TAK1
def: "Toll-like receptor pathway" [XX:<new dbxref>]
xref_analog: PubMed:15125833
is_a: IEV:0000250 ! Phosphorylation of IKK complex by MAPKKK
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0000785
name: Regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
is_a: IEV:0001400 ! Regulation of Toll-like receptor pathway
relationship: part_of IEV:0000239 ! Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000786
name: Negative regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
is_a: IEV:0000785 ! Regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
is_a: IEV:0001673 ! Negative regulation of Toll-like receptor pathway

[Term]
id: IEV:0000787
name: Positive regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK- NF-kappaB cascade)
is_a: IEV:0000785 ! Regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)
is_a: IEV:0001674 ! Positive regulation of Toll-like receptor pathway

[Term]
id: IEV:0000788
name: Binding of NF-kappaB (p65) and PPAR
xref_analog: PubMed:14587029
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000786 ! Negative regulation of Toll-like receptor pathway (through LPS, TLR4, MyD88, IRAK-1, TAK1 and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000789
name: PPAR signaling
related_synonym: "peroxisome proliferator-activated receptor signaling" []
xref_analog: KEGG:hsa03320
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000790
name: Binding of ligand and PPAR
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000789 ! PPAR signaling

[Term]
id: IEV:0000791
name: Binding outside the nuclear membrane
is_a: IEV:0000013 ! Binding in cytosol
is_a: IEV:0000017 ! Binding in nuclear membrane

[Term]
id: IEV:0000792
name: Binding of PPAR and nuclear receptor
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000789 ! PPAR signaling

[Term]
id: IEV:0000793
name: Binding of PPAR and PPRE
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000789 ! PPAR signaling

[Term]
id: IEV:0000794
name: Binding of fatty acid and PPAR
is_a: IEV:0000790 ! Binding of ligand and PPAR

[Term]
id: IEV:0000795
name: Binding of PPAR and transcriptional factor
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000789 ! PPAR signaling

[Term]
id: IEV:0000796
name: Binding of PPAR and RXR
is_a: IEV:0000792 ! Binding of PPAR and nuclear receptor

[Term]
id: IEV:0000797
name: Phosphorylation of PPAR by kinase
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000789 ! PPAR signaling

[Term]
id: IEV:0000798
name: Regulation of PPAR signaling
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000789 ! PPAR signaling

[Term]
id: IEV:0000799
name: Negative regulation of PPAR signaling
is_a: IEV:0000798 ! Regulation of PPAR signaling
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000800
name: Positive regulation of PPAR signaling
is_a: IEV:0000798 ! Regulation of PPAR signaling
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000801
name: Dephosphorylation of PPAR by phosphatase
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0000799 ! Negative regulation of PPAR signaling

[Term]
id: IEV:0000802
name: TNFR2 signaling pathway (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0002409 ! TNFR2 signaling pathway

[Term]
id: IEV:0000803
name: Trimerization of TNFR2
related_synonym: "TNFR2 trimerization" []
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000804
name: Binding of TNF homotrimer and TNFR2
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000805
name: Binding of TNFR2 and TRAF2
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000806
name: Binding of TNFR2 and TRAF1
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000807
name: Activation of MEKK1 by RIP
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000808
name: Activation of NIK by RIP
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000809
name: Phosphorylation of MEKK1 by NIK
is_a: IEV:0000633 ! Phosphorylation of MAPKKK by MAPKKKK
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0000810
name: Phosphorylation of IKK complex by MEKK1
xref_analog: GO:0007250
is_a: IEV:0000250 ! Phosphorylation of IKK complex by MAPKKK

[Term]
id: IEV:0000811
name: Phosphorylation of MKK4/7 by ASK1
def: "TNFR1 signaling" [XX:<new dbxref>]
xref_analog: GO:0007256
is_a: IEV:0000227 ! Phosphorylation of MKK4/7 by MAPKKK
relationship: part_of IEV:0000161 ! Fas signaling pathway (through caspase cascade)

[Term]
id: IEV:0000812
name: Binding of PDGF and PDGF receptor
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
relationship: part_of IEV:0001257 ! PDGF signaling pathway

[Term]
id: IEV:0000813
name: Dimerization of PDGF receptor
related_synonym: "PDGF receptor dimerization" []
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
relationship: part_of IEV:0001257 ! PDGF signaling pathway

[Term]
id: IEV:0000814
name: Autophosphorylation of PDGF receptor
is_a: IEV:0000481 ! Autophosphorylation in cytosol
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
relationship: part_of IEV:0001257 ! PDGF signaling pathway

[Term]
id: IEV:0000815
name: Binding of PDGF receptor and Grb2
alt_id: IEV:0002452
related_synonym: "Binding of (PDGF:PDGF Receptor_p) and (GRB2:SOS)" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
relationship: part_of IEV:0001257 ! PDGF signaling pathway

[Term]
id: IEV:0000816
name: Binding of PDGF receptor and Shc
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
relationship: part_of IEV:0001257 ! PDGF signaling pathway

[Term]
id: IEV:0000817
name: Transcription of c-fos by Elk-1
is_a: IEV:0000183 ! Transcription
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)

[Term]
id: IEV:0000818
name: Metabolic pathway
is_a: IEV:0000001 ! Pathway

[Term]
id: IEV:0000819
name: Phosphorylation of Elk-1 by ERK_p
def: "PDGF signaling" [XX:<new dbxref>]
is_a: IEV:0000477 ! Phosphorylation of transcriptional regulator by ERK_p

[Term]
id: IEV:0000820
name: Phosphorylation of MEK1/2(MKK1/2) by Raf
def: "PDGF signaling, Integrin signaling, G" [XX:<new dbxref>]
xref_analog: PubMed:11752597
is_a: IEV:0000475 ! Phosphorylation of MEK1/2(MKK1/2) by MAPKKK

[Term]
id: IEV:0000821
name: Regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
is_a: IEV:0001406 ! Regulation of PDGF signaling pathway
relationship: part_of IEV:0000123 ! PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)

[Term]
id: IEV:0000822
name: Negative regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
is_a: IEV:0000821 ! Regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
is_a: IEV:0001671 ! Negative regulation of PDGF signaling pathway

[Term]
id: IEV:0000823
name: Positive regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
is_a: IEV:0000821 ! Regulation of PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
is_a: IEV:0001672 ! Positive regulation of PDGF signaling pathway

[Term]
id: IEV:0000824
name: Dissociation of Ras-GDP and target protein
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000703 ! Ras-GTP hydrolysis signaling

[Term]
id: IEV:0000825
name: PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0001257 ! PDGF signaling pathway

[Term]
id: IEV:0000826
name: RalGDS-Ral-RalBP1 signaling
is_a: IEV:0001263 ! Ral mediated signaling
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)

[Term]
id: IEV:0000827
name: Binding of Ras-GTP and RalGDS
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000826 ! RalGDS-Ral-RalBP1 signaling
relationship: part_of IEV:0000857 ! RalGDS-Ral-PLD1 signaling

[Term]
id: IEV:0000828
name: GDP-GTP exchange of Ral by RalGDS
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0000826 ! RalGDS-Ral-RalBP1 signaling
relationship: part_of IEV:0000857 ! RalGDS-Ral-PLD1 signaling

[Term]
id: IEV:0000829
name: Binding of Ral-GTP and RalBP1
def: "Activation of RalBP1 by Ral-GTP" [XX:<new dbxref>]
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000826 ! RalGDS-Ral-RalBP1 signaling

[Term]
id: IEV:0000830
name: RTK signaling pathway
def: "The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand." [GO:0007169]
related_synonym: "transmembrane receptor protein tyrosine kinase signaling pathway" []
xref_analog: GO:0007169
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0000831
name: Complex formation of PI3K, Eps8, Abi1 and Sos1
xref_analog: PubMed:12515821
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000833 ! Rac activation signaling (through PI3K)

[Term]
id: IEV:0000832
name: GDP-GTP exchange of Rac by Sos1
xref_analog: PubMed:12515821
is_a: IEV:0000605 ! GDP-GTP exchange in cytosol
relationship: part_of IEV:0000833 ! Rac activation signaling (through PI3K)

[Term]
id: IEV:0000833
name: Rac activation signaling (through PI3K)
xref_analog: PubMed:12515821
is_a: IEV:0001300 ! Rac activation signaling
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000834
name: Regulation of RTK signaling pathway
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000830 ! RTK signaling pathway

[Term]
id: IEV:0000835
name: Negative regulation of RTK signaling pathway
is_a: IEV:0000834 ! Regulation of RTK signaling pathway
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000836
name: Positive regulation of RTK signaling pathway
is_a: IEV:0000834 ! Regulation of RTK signaling pathway
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000837
name: Activation of NF-kappaB by Rac-GTP
related_synonym: "NF-kappaB activation" []
xref_analog: PubMed:10740269
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000838
name: Gene expression of anti-apoptotic gene by NF-kappaB
is_a: IEV:0000783 ! Gene expression by NF-kappaB
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000839
name: Regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
is_a: IEV:0001406 ! Regulation of PDGF signaling pathway
relationship: part_of IEV:0000825 ! PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)

[Term]
id: IEV:0000840
name: Negative regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
is_a: IEV:0000839 ! Regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
is_a: IEV:0001671 ! Negative regulation of PDGF signaling pathway

[Term]
id: IEV:0000841
name: Positive regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
is_a: IEV:0000839 ! Regulation of PDGF signaling pathway (through Grb2, Sos, Ras, PI3K, AKT and IKK-NF-kappaB cascade)
is_a: IEV:0001672 ! Positive regulation of PDGF signaling pathway

[Term]
id: IEV:0000842
name: Binding of ligand and RTK
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000843
name: Autophosphorylation of RTK
is_a: IEV:0000481 ! Autophosphorylation in cytosol
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000844
name: Binding of RTK and Grb2
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000845
name: Binding of RTK and Shc
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000846
name: Dimerization of RTK
related_synonym: "RTK dimerization" []
related_synonym: "transmembrane receptor protein tyrosine kinase activation (dimerization)" []
xref_analog: GO:0007171
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000847
name: RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: part_of IEV:0000830 ! RTK signaling pathway

[Term]
id: IEV:0000848
name: RalGDS activation signaling (through Grb2 and Sos)
related_synonym: "Grb2-Sos-Ras-RalGDS signaling" []
is_a: IEV:0000458 ! Protein activation/inactivation signaling
is_a: IEV:0001258 ! Ras mediated signaling
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000849
name: Activation of RalGDS by Ras-GTP
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000848 ! RalGDS activation signaling (through Grb2 and Sos)

[Term]
id: IEV:0000850
name: Rac-GTP hydrolysis signaling
is_a: IEV:0000684 ! Small GTPase hydrolysis signaling
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)

[Term]
id: IEV:0000851
name: Hydrolysis of GTP by Rac
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000850 ! Rac-GTP hydrolysis signaling

[Term]
id: IEV:0000852
name: Dissociation of Rac-GDP and target protein
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000850 ! Rac-GTP hydrolysis signaling

[Term]
id: IEV:0000853
name: Regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
is_a: IEV:0000834 ! Regulation of RTK signaling pathway
relationship: part_of IEV:0000847 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)

[Term]
id: IEV:0000854
name: Negative regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
is_a: IEV:0000835 ! Negative regulation of RTK signaling pathway
is_a: IEV:0000853 ! Regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)

[Term]
id: IEV:0000855
name: Positive regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)
is_a: IEV:0000836 ! Positive regulation of RTK signaling pathway
is_a: IEV:0000853 ! Regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral, RalBP1 and Rac-GTP hydrolysis signaling)

[Term]
id: IEV:0000856
name: RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
relationship: part_of IEV:0000830 ! RTK signaling pathway

[Term]
id: IEV:0000857
name: RalGDS-Ral-PLD1 signaling
is_a: IEV:0001263 ! Ral mediated signaling
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000858
name: Binding of Ral-GTP and Phospholipase D1
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000857 ! RalGDS-Ral-PLD1 signaling

[Term]
id: IEV:0000859
name: Hydrolysis of phosphatidic acid by PLD1
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000860
name: Regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
is_a: IEV:0000834 ! Regulation of RTK signaling pathway
relationship: part_of IEV:0000856 ! RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000861
name: Negative regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
is_a: IEV:0000835 ! Negative regulation of RTK signaling pathway
is_a: IEV:0000860 ! Regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000862
name: Positive regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)
is_a: IEV:0000836 ! Positive regulation of RTK signaling pathway
is_a: IEV:0000860 ! Regulation of RTK signaling pathway (through Grb2, Sos, Ras, RalGDS, Ral and PLD)

[Term]
id: IEV:0000863
name: BMP signaling pathway
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor." [GO:0030509]
related_synonym: "BMP receptor signaling pathway" [GO:0030509]
xref_analog: GO:0030509
is_a: IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000864
name: TGF beta signaling pathway
def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands." [GO:0007179]
related_synonym: "transforming growth factor beta receptor signaling pathway" [GO:0007179]
xref_analog: GO:0007179
xref_analog: KEGG:hsa04350
is_a: IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000865
name: EGF signaling pathway
def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands." [GO:0007173]
related_synonym: "EGF receptor signaling pathway" [GO:0007173]
related_synonym: "EGFR signaling pathway" [GO:0007173]
related_synonym: "epidermal growth factor receptor signaling pathway" [GO:0007173]
xref_analog: GO:0007173
is_a: IEV:0000830 ! RTK signaling pathway

[Term]
id: IEV:0000866
name: NGF signaling pathway
def: "The series of molecular signals generated as a consequence of the nerve growth factor receptor binding to one of its physiological ligands." [GO:0048011]
related_synonym: "nerve growth factor receptor signaling pathway" [GO:0048011]
related_synonym: "NGF receptor signaling pathway" [GO:0048011]
xref_analog: GO:0048011
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000830 ! RTK signaling pathway
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0000867
name: EPO signaling pathway
is_a: IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0000868
name: p53 degradation signaling
xref_analog: PubMed:10721693
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
relationship: part_of IEV:0001108 ! Negative feedback regulation of p53 signaling pathway by MDM2

[Term]
id: IEV:0000869
name: Ubiquitination of p53 by Mdm2
xref_analog: PubMed:10721693
xref_analog: PubMed:15021897
is_a: IEV:0001932 ! Ubiquitination of p53 by ubiquitin ligase
relationship: part_of IEV:0000868 ! p53 degradation signaling

[Term]
id: IEV:0000870
name: Binding of Mdm2 and p19ARF
xref_analog: PubMed:15021897
is_a: IEV:0001934 ! Binding of Mdm2 and ARF
relationship: part_of IEV:0000165 ! p53 signaling pathway (through p21)
relationship: part_of IEV:0001107 ! p53 signaling pathway (through GADD45)
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0000871
name: Ubiquitination in nucleus
is_a: IEV:0000012 ! Ubiquitination

[Term]
id: IEV:0000872
name: DNA repair
def: "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [GO:0006281]
xref_analog: GO:0006281
is_a: IEV:0000071 ! Molecular event

[Term]
id: IEV:0000873
name: Regulation of TGF beta signaling pathway
def: "Any process that modulates the frequency, rate or extent of activity of any TGFbeta receptor signaling pathway." [GO:0017015]
xref_analog: GO:0017015
is_a: IEV:0000145 ! Regulation pathway
is_a: IEV:0000879 ! Regulation of TGF beta super family signaling pathway
relationship: part_of IEV:0000864 ! TGF beta signaling pathway

[Term]
id: IEV:0000874
name: Negative regulation of TGF beta signaling pathway
def: "Any process that stops, prevents or reduces the rate, frequency or extent of any TGFbeta receptor signaling pathway." [GO:0030512]
xref_analog: GO:0030512
is_a: IEV:0000873 ! Regulation of TGF beta signaling pathway
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0000875
name: Positive regulation of TGF beta signaling pathway
def: "Any process that activates or increases the rate, frequency or extent of TGFbeta receptor signaling pathway activity." [GO:0030511]
xref_analog: GO:0030511
is_a: IEV:0000873 ! Regulation of TGF beta signaling pathway
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0000876
name: Regulation of TGF beta super family signaling pathway (through p38 cascade)
is_a: IEV:0000879 ! Regulation of TGF beta super family signaling pathway
relationship: part_of IEV:0000059 ! TGF beta super family signaling pathway (through p38 cascade)

[Term]
id: IEV:0000877
name: Negative regulation of TGF beta super family signaling pathway (through p38 cascade)
is_a: IEV:0000876 ! Regulation of TGF beta super family signaling pathway (through p38 cascade)
is_a: IEV:0000880 ! Negative regulation of TGF beta super family signaling pathway

[Term]
id: IEV:0000878
name: Positive regulation of TGF beta super family signaling pathway (through p38 cascade)
is_a: IEV:0000876 ! Regulation of TGF beta super family signaling pathway (through p38 cascade)
is_a: IEV:0000881 ! Positive regulation of TGF beta super family signaling pathway

[Term]
id: IEV:0000879
name: Regulation of TGF beta super family signaling pathway
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0000880
name: Negative regulation of TGF beta super family signaling pathway
is_a: IEV:0000879 ! Regulation of TGF beta super family signaling pathway

[Term]
id: IEV:0000881
name: Positive regulation of TGF beta super family signaling pathway
is_a: IEV:0000879 ! Regulation of TGF beta super family signaling pathway

[Term]
id: IEV:0000882
name: Regulation of BMP signaling pathway
def: "Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GO:0030510]
xref_analog: GO:0030510
is_a: IEV:0000879 ! Regulation of TGF beta super family signaling pathway
relationship: part_of IEV:0000863 ! BMP signaling pathway

[Term]
id: IEV:0000883
name: Negative regulation of BMP signaling pathway
def: "Any process that stops, prevents or reduces the rate, frequency or extent of BMP signaling pathway activity." [GO:0030514]
xref_analog: GO:0030514
is_a: IEV:0000880 ! Negative regulation of TGF beta super family signaling pathway
is_a: IEV:0000882 ! Regulation of BMP signaling pathway

[Term]
id: IEV:0000884
name: Positive regulation of BMP signaling pathway
def: "Any process that activates or increases the rate, frequency or extent of BMP signaling pathway activity." [GO:0030513]
xref_analog: GO:0030513
is_a: IEV:0000881 ! Positive regulation of TGF beta super family signaling pathway
is_a: IEV:0000882 ! Regulation of BMP signaling pathway

[Term]
id: IEV:0000885
name: Negative feedback regulation pathway of TGF beta superfamily signaling
is_a: IEV:0000880 ! Negative regulation of TGF beta super family signaling pathway

[Term]
id: IEV:0000886
name: Gene expression of smad6/7 by R-smad:smad4
is_a: IEV:0001142 ! Gene expression by Smad complex
relationship: part_of IEV:0000903 ! Negative feedback regulation pathway of TGF beta superfamily signaling by (binding of smad6/7 and TGF beta receptor I)

[Term]
id: IEV:0000887
name: Binding of smad6/7 and TGF beta receptor I
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000903 ! Negative feedback regulation pathway of TGF beta superfamily signaling by (binding of smad6/7 and TGF beta receptor I)

[Term]
id: IEV:0000888
name: Phosphorylation of R-smad:smad4 by MAPK
xref_analog: PubMed:11752591
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001846 ! Negative regulation of (nuclear import of R-smad:smad4) in TGF beta super family signaling pathway

[Term]
id: IEV:0000889
name: TGF beta receptor I degradation signaling
xref_analog: PubMed:11163210
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
relationship: part_of IEV:0000905 ! Negative feedback regulation pathway of TGF beta superfamily signaling by (TGF receptor degradation by smurf)

[Term]
id: IEV:0000890
name: Complex formation of smad7 and smurf2
xref_analog: PubMed:11163210
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000889 ! TGF beta receptor I degradation signaling
relationship: part_of IEV:0000895 ! R-smad degradation signaling

[Term]
id: IEV:0000891
name: Binding of (smad7:smurf2) and TGF beta type I receptor
xref_analog: PubMed:11163210
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000889 ! TGF beta receptor I degradation signaling

[Term]
id: IEV:0000892
name: Ubiquitination of TGF beta receptor I by smurf2
xref_analog: PubMed:11163210
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000889 ! TGF beta receptor I degradation signaling

[Term]
id: IEV:0000893
name: Proteasome degradation of TGF beta receptor I by proteasome
xref_analog: PubMed:11163210
is_a: IEV:0000206 ! Proteasome degradation in plasma membrane
relationship: part_of IEV:0000889 ! TGF beta receptor I degradation signaling

[Term]
id: IEV:0000894
name: Dissociation of (smad7:smurf2) and TGF beta receptor I_Ub
xref_analog: PubMed:11163210
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000889 ! TGF beta receptor I degradation signaling

[Term]
id: IEV:0000895
name: R-smad degradation signaling
def: "The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome." [GO:0030579]
related_synonym: "ubiquitin-dependent SMAD protein breakdown" []
related_synonym: "ubiquitin-dependent SMAD protein catabolic process" []
related_synonym: "ubiquitin-dependent SMAD protein catabolism" []
related_synonym: "ubiquitin-dependent SMAD protein degradation" []
xref_analog: GO:0030579
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
relationship: part_of IEV:0000904 ! Negative feedback regulation pathway of TGF beta superfamily signaling by (R-smad degradation through smurf1/2)

[Term]
id: IEV:0000896
name: Binding of (smad7:smurf1/2) and R-smad
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000895 ! R-smad degradation signaling

[Term]
id: IEV:0000897
name: Ubiquitination of R-smad_Ub by smurf1/2
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000895 ! R-smad degradation signaling

[Term]
id: IEV:0000898
name: Dissociation of (smad7:smurf1/2) and R-smad_Ub
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000895 ! R-smad degradation signaling

[Term]
id: IEV:0000899
name: Proteasome degradation of R-smad by proteasome
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000895 ! R-smad degradation signaling

[Term]
id: IEV:0000900
name: Nuclear export of mRNA (smad6/7)
is_a: IEV:0000909 ! Nuclear export of mRNA
relationship: part_of IEV:0000886 ! Gene expression of smad6/7 by R-smad:smad4

[Term]
id: IEV:0000901
name: Transcription of smad6/7 by R-smad:smad4
is_a: IEV:0000155 ! Transcription by R-smad:smad4
relationship: part_of IEV:0000886 ! Gene expression of smad6/7 by R-smad:smad4

[Term]
id: IEV:0000902
name: Translation of smad6/7
is_a: IEV:0000219 ! Translation
relationship: part_of IEV:0000886 ! Gene expression of smad6/7 by R-smad:smad4

[Term]
id: IEV:0000903
name: Negative feedback regulation pathway of TGF beta superfamily signaling by (binding of smad6/7 and TGF beta receptor I)
is_a: IEV:0000885 ! Negative feedback regulation pathway of TGF beta superfamily signaling

[Term]
id: IEV:0000904
name: Negative feedback regulation pathway of TGF beta superfamily signaling by (R-smad degradation through smurf1/2)
is_a: IEV:0000885 ! Negative feedback regulation pathway of TGF beta superfamily signaling

[Term]
id: IEV:0000905
name: Negative feedback regulation pathway of TGF beta superfamily signaling by (TGF receptor degradation by smurf)
is_a: IEV:0000885 ! Negative feedback regulation pathway of TGF beta superfamily signaling

[Term]
id: IEV:0000906
name: Gene expression of smad7 by R-smad:smad4
is_a: IEV:0001142 ! Gene expression by Smad complex
relationship: part_of IEV:0000904 ! Negative feedback regulation pathway of TGF beta superfamily signaling by (R-smad degradation through smurf1/2)
relationship: part_of IEV:0000905 ! Negative feedback regulation pathway of TGF beta superfamily signaling by (TGF receptor degradation by smurf)

[Term]
id: IEV:0000907
name: Transcription of smad7 by R-smad:smad4
is_a: IEV:0000155 ! Transcription by R-smad:smad4
is_a: IEV:0000901 ! Transcription of smad6/7 by R-smad:smad4
relationship: part_of IEV:0000906 ! Gene expression of smad7 by R-smad:smad4

[Term]
id: IEV:0000908
name: Translation of smad7
is_a: IEV:0000219 ! Translation
is_a: IEV:0000902 ! Translation of smad6/7
relationship: part_of IEV:0000906 ! Gene expression of smad7 by R-smad:smad4

[Term]
id: IEV:0000909
name: Nuclear export of mRNA
def: "The directed movement of mRNA from the nucleus to the cytoplasm." [GO:0006406]
related_synonym: "mRNA export from nucleus" []
related_synonym: "mRNA export out of nucleus" []
related_synonym: "mRNA transport from nucleus to cytoplasm" []
related_synonym: "mRNA-nucleus export" []
xref_analog: GO:0006406
is_a: IEV:0000019 ! Nuclear export
relationship: part_of IEV:0000182 ! Gene expression

[Term]
id: IEV:0000910
name: DR4/5 signaling pathway
related_synonym: "TRAIL signaling" []
is_a: IEV:0000465 ! TNFR signaling pathway

[Term]
id: IEV:0000911
name: DR3 signaling pathway
is_a: IEV:0000465 ! TNFR signaling pathway

[Term]
id: IEV:0000912
name: Ligation
def: "EC.6 catalyzed process" [XX:<new dbxref>]
xref_analog: EC:6
is_a: IEV:0002721 ! enzymatic reaction

[Term]
id: IEV:0000913
name: Transference
def: "EC.2 catalyzed process" [XX:<new dbxref>]
xref_analog: EC:2
is_a: IEV:0002721 ! enzymatic reaction

[Term]
id: IEV:0000914
name: Oxidation/Reduction
def: "EC.1 catalyzed process" [XX:<new dbxref>]
xref_analog: EC:1
is_a: IEV:0002721 ! enzymatic reaction

[Term]
id: IEV:0000915
name: Isomerization
def: "EC.5 catalyzed process" [XX:<new dbxref>]
xref_analog: EC:5
is_a: IEV:0002721 ! enzymatic reaction

[Term]
id: IEV:0000916
name: Reduction
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0000917
name: Lyase process
def: "EC.4 catalyzed process\n\n[STKE:0456] Enzyme that catalyzes the cleavage of C-C, C-O, C-S, C-N or other bonds by other means than by hydrolysis or oxidation, with two substrates in one reaction direction, and one in the other. In the latter direction, a molecule (of carbon dioxide, water, etc) is eliminated, thus creating a new double bond or a new ring.\n\n[GO:0016829] Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring\n" [GO:0016829, STKE:0456]
xref_analog: EC:4
xref_analog: GO:0016829
xref_analog: STKE:0456
is_a: IEV:0002721 ! enzymatic reaction

[Term]
id: IEV:0000918
name: Palmitoylation
def: "Reversible reaction that can affect C,K,T or S residues." [MI:0216]
xref_analog: MI:0216
is_a: IEV:0002681 ! lipid addition

[Term]
id: IEV:0000919
name: Farnesylation
def: "Reversible reaction that can affect C residue." [MI:0206]
xref_analog: MI:0206
is_a: IEV:0000921 ! Isoprenylation
is_a: IEV:0002681 ! lipid addition

[Term]
id: IEV:0000920
name: Geranylgeranylation
def: "Reversible reaction that can affect C residue." [MI:0209]
xref_analog: MI:0209
is_a: IEV:0000921 ! Isoprenylation
is_a: IEV:0002681 ! lipid addition

[Term]
id: IEV:0000921
name: Isoprenylation
related_synonym: "Polyisoprenylation" []
is_a: IEV:0000913 ! Transference

[Term]
id: IEV:0000922
name: Unknown interaction
is_a: IEV:0000220 ! Unknown process

[Term]
id: IEV:0000923
name: Binding of FasL and Fas
related_synonym: "FASL binds FAS Receptor" []
related_synonym: "induction of apoptosis by extracellular signals" []
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000161 ! Fas signaling pathway (through caspase cascade)

[Term]
id: IEV:0000924
name: Trimerization of Fas
related_synonym: "Fas trimerization" []
related_synonym: "Trimerization of the FASL:FAS receptor complex" []
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000161 ! Fas signaling pathway (through caspase cascade)

[Term]
id: IEV:0000925
name: Binding of Fas and FADD
related_synonym: "FasL:Fas binds FADD" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000161 ! Fas signaling pathway (through caspase cascade)

[Term]
id: IEV:0000926
name: Binding of FADD and pro-caspase8/10
related_synonym: "DISC complex formation" []
related_synonym: "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-10" []
related_synonym: "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000910 ! DR4/5 signaling pathway

[Term]
id: IEV:0000927
name: Binding of FADD and pro-caspase8
related_synonym: "DISC complex formation" []
is_a: IEV:0000926 ! Binding of FADD and pro-caspase8/10
relationship: part_of IEV:0001008 ! Caspase8 activation signaling

[Term]
id: IEV:0000928
name: Binding of FADD and pro-caspase10
related_synonym: "DISC complex formation" []
related_synonym: "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-10" []
is_a: IEV:0000926 ! Binding of FADD and pro-caspase8/10
relationship: part_of IEV:0001004 ! Caspase10 activation signaling

[Term]
id: IEV:0000929
name: Caspase8/10 activation signaling
xref_analog: GO:0006919
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0000938 ! Caspase cascade (not through mitochondria)

[Term]
id: IEV:0000930
name: Homodimerization of Caspase8
related_synonym: "Caspase8 homodimer formation" []
related_synonym: "Formation of Caspase-8 dimer" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001008 ! Caspase8 activation signaling

[Term]
id: IEV:0000931
name: Hydrolysis of pro-caspase8
related_synonym: "Activation of Pro-Caspase 8" []
related_synonym: "Cleavage of pro-caspase8" []
xref_analog: GO:0006919
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0001008 ! Caspase8 activation signaling

[Term]
id: IEV:0000932
name: Binding of TNFR1, TRADD, TRAF2 and RIP
related_synonym: "TNF:TNF-R1 binds TRADD, TRAF2 and RIP Complex" []
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000114 ! TNFR1 signaling pathway (through caspase cascade)
relationship: part_of IEV:0000455 ! TNFR1 signaling pathway (through JNK cascade)

[Term]
id: IEV:0000933
name: Dissociation of TRADD:TRAF2:RIP complex and TNF:TNFR1
related_synonym: "TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex" []
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000114 ! TNFR1 signaling pathway (through caspase cascade)

[Term]
id: IEV:0000934
name: Binding of TRADD and RIP
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000932 ! Binding of TNFR1, TRADD, TRAF2 and RIP

[Term]
id: IEV:0000935
name: Binding of DR4/5 and APO-2L
related_synonym: "TRAIL Binds TRAIL-Receptor2" []
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000910 ! DR4/5 signaling pathway

[Term]
id: IEV:0000936
name: Trimerization of DR4/5
related_synonym: "DR4/5 trimerization" []
related_synonym: "Trimerization of TRAIL: TRAIL receptor-2 complex" []
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000910 ! DR4/5 signaling pathway

[Term]
id: IEV:0000937
name: Binding of DR4/5 and FADD
related_synonym: "TRAIL:TRAIL receptor-2 Trimer Binds FADD" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000910 ! DR4/5 signaling pathway

[Term]
id: IEV:0000938
name: Caspase cascade (not through mitochondria)
related_synonym: "Intrinsic Pathway for Apoptosis" []
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
relationship: part_of IEV:0000114 ! TNFR1 signaling pathway (through caspase cascade)
relationship: part_of IEV:0000128 ! Caspase Cascade
relationship: part_of IEV:0000161 ! Fas signaling pathway (through caspase cascade)

[Term]
id: IEV:0000939
name: Caspase cascade (through mitochondria)
related_synonym: "Intrinsic Pathway for Apoptosis" []
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
relationship: part_of IEV:0000114 ! TNFR1 signaling pathway (through caspase cascade)
relationship: part_of IEV:0000128 ! Caspase Cascade
relationship: part_of IEV:0000161 ! Fas signaling pathway (through caspase cascade)
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0000940
name: Apoptotic factor activation signaling
def: "The conversion of proteins that induce or sustain apoptosis to an active form." [GO:0008633]
related_synonym: "activation of pro-apoptotic gene products" []
xref_analog: GO:0008633
is_a: IEV:0000458 ! Protein activation/inactivation signaling

[Term]
id: IEV:0000941
name: BID activation signaling
related_synonym: "Activation, myristoylation of BID and translocation to mitochondria" []
xref_analog: GO:0008633
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0000942
name: Hydrolysis of BID by caspase8
related_synonym: "Caspase-8 activates BID by cleavage" []
xref_analog: GO:0008633
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000941 ! BID activation signaling

[Term]
id: IEV:0000943
name: Hydrolysis of BID by granzyme B
related_synonym: "Granzyme-B activates BID by cleavage" []
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000941 ! BID activation signaling

[Term]
id: IEV:0000944
name: Myristoylation of tBID by NMT1
xref_analog: PubMed:11099414
is_a: IEV:0000945 ! Myristoylation in cytosol
relationship: part_of IEV:0000941 ! BID activation signaling

[Term]
id: IEV:0000945
name: Myristoylation in cytosol
is_a: IEV:0000222 ! Myristoylation

[Term]
id: IEV:0000946
name: Isoprenylation in unidentified cellular location
is_a: IEV:0000921 ! Isoprenylation

[Term]
id: IEV:0000947
name: Myristoylation in unidentified cellular location
is_a: IEV:0000222 ! Myristoylation

[Term]
id: IEV:0000948
name: Translocation of tBID from the cytosol to the mitochondria membrane
xref_analog: GO:0001844
is_a: IEV:0000412 ! Translocation from cytosol to mitochondria membrane
relationship: part_of IEV:0000941 ! BID activation signaling

[Term]
id: IEV:0000949
name: Dissociation of tBID and Bcl-2
is_a: IEV:0000950 ! Dissociation in the mitochondria membrane
relationship: part_of IEV:0001667 ! Bcl-2/Bcl-xL inactivation signaling

[Term]
id: IEV:0000950
name: Dissociation in the mitochondria membrane
is_a: IEV:0001033 ! Dissociation in mitochondria

[Term]
id: IEV:0000951
name: NOXA activation signaling
related_synonym: "Activation of NOXA and translocation to mitochondria" []
xref_analog: GO:0008633
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0000952
name: Transcription of NOXA by p53
related_synonym: "Transactivation of NOXA by p53" []
is_a: IEV:0001652 ! Gene expression of NOXA by p53
is_a: IEV:0001661 ! Transcription of apoptotic factor by p53
relationship: part_of IEV:0000951 ! NOXA activation signaling

[Term]
id: IEV:0000953
name: Transcription of NOXA by E2F-1
related_synonym: "Transactivation of NOXA by E2F1" []
is_a: IEV:0001102 ! Transcription by E2F-1
relationship: part_of IEV:0000951 ! NOXA activation signaling

[Term]
id: IEV:0000954
name: Translocation of NOXA from the cytosol to the mitochondria membrane
xref_analog: GO:0001844
is_a: IEV:0000412 ! Translocation from cytosol to mitochondria membrane
relationship: part_of IEV:0000951 ! NOXA activation signaling

[Term]
id: IEV:0000955
name: PUMA activation signaling
related_synonym: "Activation of NOXA and translocation to mitochondria" []
xref_analog: GO:0008633
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0000956
name: Transcription of PUMA by E2F-1
related_synonym: "Transactivation of PUMA by E2F1" []
is_a: IEV:0001102 ! Transcription by E2F-1
relationship: part_of IEV:0000955 ! PUMA activation signaling

[Term]
id: IEV:0000957
name: Transcription of PUMA by p53
related_synonym: "Transactivation of PUMA by p53" []
is_a: IEV:0001653 ! Gene expression of PUMA by p53
is_a: IEV:0001661 ! Transcription of apoptotic factor by p53
relationship: part_of IEV:0000955 ! PUMA activation signaling

[Term]
id: IEV:0000958
name: Translocation of PUMA from cytosol to the mitochondria membrane
related_synonym: "Translocation of PUMA protein to mitochondria" []
xref_analog: GO:0001844
is_a: IEV:0000412 ! Translocation from cytosol to mitochondria membrane
relationship: part_of IEV:0000955 ! PUMA activation signaling

[Term]
id: IEV:0000959
name: Bim activation signaling
related_synonym: "Activation of BIM and translocation to mitochondria" []
xref_analog: GO:0008633
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0000960
name: Phosphorylation of DLC1 by MAPK8
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000959 ! Bim activation signaling

[Term]
id: IEV:0000961
name: Dissociation of Bim and dynein:myosin V
is_a: IEV:0000023 ! Dissociation in cytosol
is_a: IEV:0000507 ! Dissociation in unidentified cellular location
relationship: part_of IEV:0000959 ! Bim activation signaling

[Term]
id: IEV:0000962
name: Translocation of Bim from the cytosol to the mitochondria membrane
related_synonym: "Translocation of BIM to mitochondria" []
xref_analog: GO:0001844
is_a: IEV:0000412 ! Translocation from cytosol to mitochondria membrane
relationship: part_of IEV:0000959 ! Bim activation signaling

[Term]
id: IEV:0000963
name: Bmf activation signaling
related_synonym: "Activation of BMF and translocation to mitochondria" []
xref_analog: GO:0008633
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0000964
name: Phosphorylation of DLC2 by MAPK8
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000963 ! Bmf activation signaling

[Term]
id: IEV:0000965
name: Dissociation of Bmf and dynein:myosin V
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000963 ! Bmf activation signaling

[Term]
id: IEV:0000966
name: Translocation of Bmf from the cytosol to the mitochondria membrane
related_synonym: "Translocation of BMF to mitochondria" []
xref_analog: GO:0001844
is_a: IEV:0000412 ! Translocation from cytosol to mitochondria membrane
relationship: part_of IEV:0000963 ! Bmf activation signaling

[Term]
id: IEV:0000967
name: Inactivation in mitochondria membrane
is_a: IEV:0000007 ! Unknown inactivation

[Term]
id: IEV:0000968
name: Inactivation of Bcl-2 by Bad
is_a: IEV:0000977 ! Inactivation of Bcl-2 family by pro-apoptotic factor

[Term]
id: IEV:0000969
name: Inactivation of Bcl-xl by Bad
is_a: IEV:0000977 ! Inactivation of Bcl-2 family by pro-apoptotic factor

[Term]
id: IEV:0000970
name: Inactivation of tBid by Bcl-2
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000967 ! Inactivation in mitochondria membrane
relationship: part_of IEV:0000177 ! Negative regulation of Caspase cascade (through mitochondria)

[Term]
id: IEV:0000971
name: Inactivation of Bcl-2 by Bim
is_a: IEV:0000977 ! Inactivation of Bcl-2 family by pro-apoptotic factor

[Term]
id: IEV:0000972
name: Inactivation of Bcl-xl by tBid
is_a: IEV:0000977 ! Inactivation of Bcl-2 family by pro-apoptotic factor

[Term]
id: IEV:0000973
name: Inactivation of Bcl-xl by Bim
is_a: IEV:0000977 ! Inactivation of Bcl-2 family by pro-apoptotic factor

[Term]
id: IEV:0000974
name: Inactivation of Bcl-2 by NOXA
is_a: IEV:0000977 ! Inactivation of Bcl-2 family by pro-apoptotic factor

[Term]
id: IEV:0000975
name: Inactivation of Bcl-2 by PUMA
is_a: IEV:0000977 ! Inactivation of Bcl-2 family by pro-apoptotic factor

[Term]
id: IEV:0000976
name: Inactivation of Bcl-xl by PUMA
is_a: IEV:0000977 ! Inactivation of Bcl-2 family by pro-apoptotic factor

[Term]
id: IEV:0000977
name: Inactivation of Bcl-2 family by pro-apoptotic factor
related_synonym: "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members" []
is_a: IEV:0000967 ! Inactivation in mitochondria membrane
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0000978
name: Activation of Bax by tBid
related_synonym: "tBID activates BAX protein" []
xref_analog: GO:0008633
xref_analog: PubMed:10950869
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000167 ! Bax activation signaling

[Term]
id: IEV:0000979
name: Activation in mitochondria membrane
is_a: IEV:0000008 ! Unknown activation

[Term]
id: IEV:0000980
name: Bak activation signaling
related_synonym: "Activation and oligomerization of BAK protein" []
xref_analog: GO:0008633
is_a: IEV:0000940 ! Apoptotic factor activation signaling
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0000981
name: Activation of Bak by tBid
related_synonym: "tBID activates BAK protein" []
xref_analog: GO:0008633
is_a: IEV:0000979 ! Activation in mitochondria membrane
relationship: part_of IEV:0000980 ! Bak activation signaling

[Term]
id: IEV:0000982
name: Oligomerization of Bak
related_synonym: "Oligomerization of BAK at the mitochondrial membrane" []
relationship: part_of IEV:0000980 ! Bak activation signaling

[Term]
id: IEV:0000983
name: Permeabilization of mitochondria
is_obsolete: true

[Term]
id: IEV:0000984
name: Permeabilization of mitochondria and Translocation of cytochrome c/SMAC from mitochondria to cytosol
related_synonym: "Release of apoptotic factors from the mitochondria" []
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0000985
name: Translocation from mitochondria to cytosol
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0000986
name: Permeabilization of mitochondria and Translocation of SMAC from mitochondria to cytosol
related_synonym: "Release of SMAC from mitochondria" []
is_a: IEV:0000984 ! Permeabilization of mitochondria and Translocation of cytochrome c/SMAC from mitochondria to cytosol
is_a: IEV:0000985 ! Translocation from mitochondria to cytosol

[Term]
id: IEV:0000987
name: Cytochrome c mediated signaling
def: "Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, mediated by cytochrome c." [GO:0008635]
related_synonym: "Cytochrome c-mediated apoptotic response" []
related_synonym: "Effector caspase3 / 7 activation signaling (through Cyt c)" []
xref_analog: GO:0008635
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0000988
name: SMAC mediated signaling
related_synonym: "SMAC-mediated apoptotic response" []
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0000989
name: Apoptosome formation
related_synonym: "Formation of apoptosome" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001003 ! Caspase9 activation signaling

[Term]
id: IEV:0000990
name: Binding of Cyt c:Apaf1 and procaspase9
related_synonym: "Cytochrome C:Apaf-1 binds Procaspase-9" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000989 ! Apoptosome formation

[Term]
id: IEV:0000991
name: Hydrolysis of Procaspase9 to Caspase9
related_synonym: "Cleavage of Procaspase-9 to Caspase-9" []
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0001003 ! Caspase9 activation signaling

[Term]
id: IEV:0000992
name: Hydrolysis of Caspase3/6/7 by Caspase9
related_synonym: "Activation of caspases through apoptosome-mediated cleavage" []
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0001006 ! Caspase3/6/7 activation signaling (through mitochondria)

[Term]
id: IEV:0000993
name: Hydrolysis of Procaspase7 to Caspase7by Caspase9
related_synonym: "Cleavage of Procaspase-7 by the apoptosome" []
is_a: IEV:0000992 ! Hydrolysis of Caspase3/6/7 by Caspase9

[Term]
id: IEV:0000994
name: Hydrolysis of Procaspase3 to Caspase3 by Caspase9
related_synonym: "Cleavage of Procaspase-3 by the apoptosome" []
is_a: IEV:0000992 ! Hydrolysis of Caspase3/6/7 by Caspase9
relationship: part_of IEV:0003413 ! Caspase3 activation signaling (through mitochondria)

[Term]
id: IEV:0000995
name: Binding of SMAC and IAP
related_synonym: "SMAC binds to IAPs" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000988 ! SMAC mediated signaling

[Term]
id: IEV:0000996
name: Dissociation of Caspase3 and SMAC:XIAP
related_synonym: "SMAC binds XIAP:Caspase-3" []
is_a: IEV:0000997 ! Dissociation of Caspase and SMAC:IAP

[Term]
id: IEV:0000997
name: Dissociation of Caspase and SMAC:IAP
related_synonym: "SMAC-mediated dissociation of IAP:caspase complexes" []
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000988 ! SMAC mediated signaling

[Term]
id: IEV:0000998
name: Binding of SMAC and XIAP:Caspase3
related_synonym: "SMAC binds XIAP:Caspase-3" []
is_a: IEV:0000995 ! Binding of SMAC and IAP

[Term]
id: IEV:0000999
name: Binding of SMAC and XIAP:Caspase7
related_synonym: "SMAC binds XIAP:Caspase-7" []
is_a: IEV:0000995 ! Binding of SMAC and IAP

[Term]
id: IEV:0001000
name: Binding of SMAC and XIAP:Caspase9
related_synonym: "SMAC binds XIAP:Caspase-9" []
is_a: IEV:0000995 ! Binding of SMAC and IAP

[Term]
id: IEV:0001001
name: Dissociation of Caspase7 and SMAC:XIAP
related_synonym: "Dissociation of Caspase-7 from SMAC:XIAP:Caspase-7" []
is_a: IEV:0000997 ! Dissociation of Caspase and SMAC:IAP

[Term]
id: IEV:0001002
name: Dissociation of Caspase9 and SMAC:XIAP
related_synonym: "Dissociation of Caspase-9 from SMAC:XIAP:Caspase-9" []
is_a: IEV:0000997 ! Dissociation of Caspase and SMAC:IAP

[Term]
id: IEV:0001003
name: Caspase9 activation signaling
xref_analog: GO:0006919
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0000987 ! Cytochrome c mediated signaling

[Term]
id: IEV:0001004
name: Caspase10 activation signaling
xref_analog: GO:0006919
xref_analog: GO:0008633
relationship: part_of IEV:0000929 ! Caspase8/10 activation signaling

[Term]
id: IEV:0001005
name: Homodimerization of Caspase9
related_synonym: "Caspase9 homodimer formation" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001003 ! Caspase9 activation signaling

[Term]
id: IEV:0001006
name: Caspase3/6/7 activation signaling (through mitochondria)
related_synonym: "Activation of Effector Caspases" []
xref_analog: GO:0006919
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0000987 ! Cytochrome c mediated signaling

[Term]
id: IEV:0001007
name: Caspase3/6/7 homodimer formation
relationship: part_of IEV:0001006 ! Caspase3/6/7 activation signaling (through mitochondria)
relationship: part_of IEV:0001013 ! Caspase3/6/7 activation signaling (not through mitochondria)

[Term]
id: IEV:0001008
name: Caspase8 activation signaling
related_synonym: "Activation of Pro-Caspase 8" []
xref_analog: GO:0006919
xref_analog: GO:0008633
relationship: part_of IEV:0000929 ! Caspase8/10 activation signaling
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0001009
name: Hydrolysis of pro-caspase10
related_synonym: "Activation of Pro-Caspase10" []
related_synonym: "Cleavage of pro-caspase10" []
xref_analog: GO:0006919
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0001004 ! Caspase10 activation signaling

[Term]
id: IEV:0001010
name: Homodimerization of Caspase10
related_synonym: "Caspase10 homodimer formation" []
related_synonym: "Formation of Caspase10 dimer" []
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001004 ! Caspase10 activation signaling

[Term]
id: IEV:0001011
name: AIF mediated signaling
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)
relationship: part_of IEV:0001017 ! DNA fragmentation during apoptosis
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0001012
name: Nuclear import of Aif
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001011 ! AIF mediated signaling

[Term]
id: IEV:0001013
name: Caspase3/6/7 activation signaling (not through mitochondria)
related_synonym: "Activation of Effector Caspases" []
xref_analog: GO:0006919
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0000938 ! Caspase cascade (not through mitochondria)

[Term]
id: IEV:0001014
name: Hydrolysis of Procaspase3/6/7 by caspase8/10
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0001013 ! Caspase3/6/7 activation signaling (not through mitochondria)

[Term]
id: IEV:0001015
name: Hydrolysis of ICAD by Caspase3/7
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0001603 ! CAD signaling

[Term]
id: IEV:0001016
name: Nuclear import of CAD
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001603 ! CAD signaling

[Term]
id: IEV:0001017
name: DNA fragmentation during apoptosis
def: "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GO:0006309]
related_synonym: "Apoptosis induced DNA fragmentation" []
xref_analog: GO:0006309
is_a: IEV:0001104 ! DNA damage
relationship: part_of IEV:0000070 ! Apoptosis (Inhibition of cell survival)

[Term]
id: IEV:0001018
name: Regulation of Caspase cascade (through mitochondria)
is_a: IEV:0000539 ! Regulation of Caspase cascade
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0001019
name: Negative regulation of Caspase cascade
is_a: IEV:0000539 ! Regulation of Caspase cascade
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0001020
name: Positive regulation of Caspase cascade
is_a: IEV:0000539 ! Regulation of Caspase cascade
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0001021
name: Regulation of Caspase cascade (not through mitochondria)
is_a: IEV:0000539 ! Regulation of Caspase cascade
relationship: part_of IEV:0000938 ! Caspase cascade (not through mitochondria)

[Term]
id: IEV:0001022
name: Negative regulation of Caspase cascade (not through mitochondria)
is_a: IEV:0001019 ! Negative regulation of Caspase cascade
is_a: IEV:0001021 ! Regulation of Caspase cascade (not through mitochondria)

[Term]
id: IEV:0001023
name: Positive regulation of Caspase cascade (not through mitochondria)
is_a: IEV:0001020 ! Positive regulation of Caspase cascade
is_a: IEV:0001021 ! Regulation of Caspase cascade (not through mitochondria)

[Term]
id: IEV:0001024
name: Binding of CAD and ICAD
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)
relationship: part_of IEV:0001022 ! Negative regulation of Caspase cascade (not through mitochondria)

[Term]
id: IEV:0001025
name: Binding of Caspase3/7/9 and IAP
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000177 ! Negative regulation of Caspase cascade (through mitochondria)

[Term]
id: IEV:0001026
name: Hydrolysis in nucleus
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0001027
name: DNA fragmentation by Aif
is_a: IEV:0001051 ! Hydrolysis in the inner space of the nuclear
relationship: part_of IEV:0001011 ! AIF mediated signaling

[Term]
id: IEV:0001028
name: DNA fragmentation by CAD
is_a: IEV:0001051 ! Hydrolysis in the inner space of the nuclear
relationship: part_of IEV:0001603 ! CAD signaling

[Term]
id: IEV:0001029
name: Hydrolysis of cytosolic protein by caspase3/6/7
related_synonym: "cleavage of cytosolic proteins during apoptosis" []
xref_analog: GO:0030972
is_a: IEV:0000685 ! Hydrolysis in cytosol
relationship: part_of IEV:0000938 ! Caspase cascade (not through mitochondria)
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0001030
name: Apoptotic factor inactivation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling

[Term]
id: IEV:0001031
name: Cytosolic cation ion concentration decline
is_a: IEV:0000771 ! Change in material concentration

[Term]
id: IEV:0001032
name: Dissociation outside the ER membrane
is_a: IEV:0000023 ! Dissociation in cytosol
is_a: IEV:0001043 ! Dissociation in the ER membrane

[Term]
id: IEV:0001033
name: Dissociation in mitochondria
is_a: IEV:0000006 ! Dissociation

[Term]
id: IEV:0001034
name: Dissociation in ER
is_a: IEV:0000006 ! Dissociation

[Term]
id: IEV:0001035
name: Binding in ER
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0001036
name: Binding in mitochondria
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0001037
name: Binding outside the ER membrane
is_a: IEV:0000013 ! Binding in cytosol
is_a: IEV:0000273 ! Binding in the ER membrane

[Term]
id: IEV:0001038
name: Dissociation outside the mitochondria membrane
is_a: IEV:0000023 ! Dissociation in cytosol
is_a: IEV:0000950 ! Dissociation in the mitochondria membrane

[Term]
id: IEV:0001039
name: Binding in the inner space of the mitochondria
is_a: IEV:0001036 ! Binding in mitochondria

[Term]
id: IEV:0001040
name: Binding in the inner space of the ER
is_a: IEV:0001035 ! Binding in ER

[Term]
id: IEV:0001041
name: Binding in inner space of nucleus
is_a: IEV:0000015 ! Binding in nucleus

[Term]
id: IEV:0001042
name: Dissociation in nucleus
is_a: IEV:0000006 ! Dissociation

[Term]
id: IEV:0001043
name: Dissociation in the ER membrane
is_a: IEV:0001034 ! Dissociation in ER

[Term]
id: IEV:0001044
name: Dissociation in the inner space of the ER
is_a: IEV:0001034 ! Dissociation in ER

[Term]
id: IEV:0001045
name: Dissociation in the inner space of the mitochondria
is_a: IEV:0001033 ! Dissociation in mitochondria

[Term]
id: IEV:0001046
name: Dissociation in the inner space of the nuclear
is_a: IEV:0001042 ! Dissociation in nucleus

[Term]
id: IEV:0001047
name: Dissociation in the nuclear membrane
is_a: IEV:0001042 ! Dissociation in nucleus

[Term]
id: IEV:0001048
name: Dissociation outside the nuclear membrane
is_a: IEV:0000023 ! Dissociation in cytosol
is_a: IEV:0001047 ! Dissociation in the nuclear membrane

[Term]
id: IEV:0001049
name: Dephosphorylation in nucleus
is_a: IEV:0000011 ! Dephosphorylation

[Term]
id: IEV:0001050
name: Dephosphorylation in the inner space or the nuclear
is_a: IEV:0001049 ! Dephosphorylation in nucleus

[Term]
id: IEV:0001051
name: Hydrolysis in the inner space of the nuclear
is_a: IEV:0001026 ! Hydrolysis in nucleus

[Term]
id: IEV:0001052
name: Isomerization in cytosol
is_a: IEV:0000915 ! Isomerization

[Term]
id: IEV:0001053
name: Isomerization in unidentified cellular location
is_a: IEV:0000915 ! Isomerization

[Term]
id: IEV:0001054
name: SUMOylation in unidentified cellular location
is_a: IEV:0000118 ! SUMOylation

[Term]
id: IEV:0001055
name: SUMOylation in cytosol
is_a: IEV:0000118 ! SUMOylation

[Term]
id: IEV:0001056
name: Proteasome degradation of cyclin D
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0001084 ! Cyclin D degradation signaling

[Term]
id: IEV:0001057
name: Lyase process in unidentified cellular location
is_a: IEV:0000917 ! Lyase process

[Term]
id: IEV:0001058
name: Oxidation/Reduction in unidentified cellular location
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0001059
name: Oxidation/Reduction in cytosol
is_a: IEV:0000914 ! Oxidation/Reduction

[Term]
id: IEV:0001060
name: Farnesylation in unidentified cellular location
is_a: IEV:0000919 ! Farnesylation

[Term]
id: IEV:0001061
name: Geranylgeranylation in unidentified cellular location
is_a: IEV:0000920 ! Geranylgeranylation

[Term]
id: IEV:0001062
name: Geranylgeranylation in cytosol
is_a: IEV:0000920 ! Geranylgeranylation

[Term]
id: IEV:0001063
name: Palmitoylation in cytosol
is_a: IEV:0000918 ! Palmitoylation

[Term]
id: IEV:0001064
name: Palmitoylation in unidentified cellular location
is_a: IEV:0000918 ! Palmitoylation

[Term]
id: IEV:0001065
name: Interaction in cytosol
is_a: IEV:0000922 ! Unknown interaction

[Term]
id: IEV:0001066
name: Interaction in unidentified cellular location
is_a: IEV:0000922 ! Unknown interaction

[Term]
id: IEV:0001067
name: Decarboxylation
xref_analog: EC:4.1.1
is_a: IEV:0000917 ! Lyase process

[Term]
id: IEV:0001068
name: Decarboxylation in the cytosol
is_a: IEV:0001067 ! Decarboxylation

[Term]
id: IEV:0001069
name: Decarboxylation in the unidentified cellular location
is_a: IEV:0001067 ! Decarboxylation

[Term]
id: IEV:0001070
name: G1-S-phase transition pathway
def: "Progression from G1 phase to S phase of the mitotic cell cycle." [GO:0000082]
xref_analog: GO:0000082
xref_analog: KEGG:hsa04110
is_a: IEV:0000366 ! Cell cycle regulation pathway

[Term]
id: IEV:0001071
name: Binding of Cdk 4/6 and cyclin D
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001070 ! G1-S-phase transition pathway

[Term]
id: IEV:0001072
name: Nuclear import of Cdk 4/6_Tp:cyclin D
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001070 ! G1-S-phase transition pathway

[Term]
id: IEV:0001074
name: Phosphorylation of RB by Cdk 4/6
is_a: IEV:0001082 ! Phosphorylation in the inner space of the nuclear
relationship: part_of IEV:0001070 ! G1-S-phase transition pathway

[Term]
id: IEV:0001075
name: Binding of E2F and DP-1
is_a: IEV:0001041 ! Binding in inner space of nucleus

[Term]
id: IEV:0001076
name: Transcription by E2F
is_a: IEV:0000183 ! Transcription
relationship: part_of IEV:0001070 ! G1-S-phase transition pathway
relationship: part_of IEV:0001095 ! S phase pathway

[Term]
id: IEV:0001077
name: Dissociation of E2F-1 and RB_p
is_a: IEV:0000390 ! Dissociation of E2F and RB_p
is_a: IEV:0001046 ! Dissociation in the inner space of the nuclear

[Term]
id: IEV:0001078
name: Binding of Cdk 2 and cyclin E
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001070 ! G1-S-phase transition pathway

[Term]
id: IEV:0001079
name: Nuclear import of Cdk 2_Tp:cyclin E
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001070 ! G1-S-phase transition pathway

[Term]
id: IEV:0001080
name: Gene expression of p21 by p53
related_synonym: "Transactivation of p21 by p53" []
is_a: IEV:0001110 ! Gene expression by p53
relationship: part_of IEV:0000165 ! p53 signaling pathway (through p21)

[Term]
id: IEV:0001081
name: Phosphorylation of RB by Cdk 2
is_a: IEV:0001082 ! Phosphorylation in the inner space of the nuclear
relationship: part_of IEV:0001070 ! G1-S-phase transition pathway
relationship: part_of IEV:0001095 ! S phase pathway

[Term]
id: IEV:0001082
name: Phosphorylation in the inner space of the nuclear
is_a: IEV:0000231 ! Phosphorylation in nucleus

[Term]
id: IEV:0001083
name: Regulation of S phase
is_a: IEV:0001403 ! Regulation of cell cycle regulation
relationship: part_of IEV:0001095 ! S phase pathway

[Term]
id: IEV:0001084
name: Cyclin D degradation signaling
def: "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions. " [GO:0008054]
xref_analog: GO:0008054
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
is_a: IEV:0000391 ! Negative regulation of G1-S-phase transition pathway

[Term]
id: IEV:0001085
name: Proteasome degradation of cyclin E
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000130 ! Cyclin E degradation signaling

[Term]
id: IEV:0001086
name: Ubiquitination of Cyclin E
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0000130 ! Cyclin E degradation signaling

[Term]
id: IEV:0001087
name: Binding of INK4 family and Cdk 4/6 [Human]
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000391 ! Negative regulation of G1-S-phase transition pathway

[Term]
id: IEV:0001088
name: Binding of p16 and Cdk 4/6
def: "Interacts strongly with CDK4 and CDK6. Inhibits their ability to interact with cyclins D. Could act as a negative regulator of the proliferation of normal cells." [UniProt:P42771]
is_a: IEV:0001087 ! Binding of INK4 family and Cdk 4/6 [Human]
relationship: part_of IEV:0001149 ! TGF beta super family signaling (through p16)

[Term]
id: IEV:0001089
name: Binding of p15 and Cdk 4/6
def: "Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest." [UniProt:P42772]
is_a: IEV:0001087 ! Binding of INK4 family and Cdk 4/6 [Human]
relationship: part_of IEV:0001139 ! TGF beta super family signaling (through p15)

[Term]
id: IEV:0001090
name: Binding of p27 and Cdk 2
def: " Involved in G1 arrest. May mediate TGF beta-induced G1 arrest. Binds to and inhibits complexes formed by cyclin E-CDK2, cyclin A-CDK2, and cyclin D1-CDK4. Interaction with nucleoporin NUP50 is required for nuclear import and for degradation of phosphorylated p27Kip1 after nuclear import" [UniProt:P46527]
is_a: IEV:0001096 ! Negative regulation of S phase
relationship: part_of IEV:0001150 ! TGF beta super family signaling (through p27)
relationship: part_of IEV:0001152 ! Negative regulation of G1-S-phase transition pathway by contact pressure (through p27)

[Term]
id: IEV:0001091
name: Binding of p21 and Cdk 2
def: " May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. May bind to and inhibit cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression." [Uniprot:P38936]
relationship: part_of IEV:0000165 ! p53 signaling pathway (through p21)
relationship: part_of IEV:0001107 ! p53 signaling pathway (through GADD45)
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)
relationship: part_of IEV:0001140 ! TGF beta super family signaling (through p21)
relationship: part_of IEV:0001153 ! Negative regulation of G1-S-phase transition pathway by contact pressure (through p21)

[Term]
id: IEV:0001092
name: Binding of GADD45 and PCNA
def: " Binds to proliferating cell nuclear antigen. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase." [UniProt:P24522]
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001107 ! p53 signaling pathway (through GADD45)

[Term]
id: IEV:0001093
name: Binding of p18 and Cdk 4/6
def: "Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB." [UniProt:P42773]
is_a: IEV:0001087 ! Binding of INK4 family and Cdk 4/6 [Human]

[Term]
id: IEV:0001094
name: Binding of p19 and Cdk 4/6
def: "Interacts strongly with CDK4 and CDK6." [Uniprot:P55273]
is_a: IEV:0001087 ! Binding of INK4 family and Cdk 4/6 [Human]

[Term]
id: IEV:0001095
name: S phase pathway
def: "Progression through S phase, the part of the cell cycle during which DNA synthesis takes place." [GO:0051320]
xref_analog: GO:0051320
xref_analog: KEGG:hsa04110
is_a: IEV:0000366 ! Cell cycle regulation pathway

[Term]
id: IEV:0001096
name: Negative regulation of S phase
is_a: IEV:0001083 ! Regulation of S phase
is_a: IEV:0001404 ! Negative regulation of cell cycle regulation

[Term]
id: IEV:0001097
name: Positive regulation of S phase
is_a: IEV:0001083 ! Regulation of S phase
is_a: IEV:0001405 ! Positive regulation of cell cycle regulation

[Term]
id: IEV:0001098
name: Dephosphorylation Cdk 2 by Cdc25A
def: "Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity. It also dephosphorylates CDK2 in complex with cyclin E, in vitro." [UniProt:P30304]
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0001070 ! G1-S-phase transition pathway
relationship: part_of IEV:0001095 ! S phase pathway

[Term]
id: IEV:0001099
name: Binding of Cdk7 and Cyclin H
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001095 ! S phase pathway

[Term]
id: IEV:0001100
name: Phosphorylation of Cdk2 by Cdk7
def: "Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II." [Uniprot:P50613]
comment: Thr160
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001070 ! G1-S-phase transition pathway
relationship: part_of IEV:0001095 ! S phase pathway

[Term]
id: IEV:0001101
name: Binding of Cdk2 and Cyclin A
relationship: part_of IEV:0001095 ! S phase pathway

[Term]
id: IEV:0001102
name: Transcription by E2F-1
is_a: IEV:0001076 ! Transcription by E2F

[Term]
id: IEV:0001103
name: p53 signaling pathway
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0001104
name: DNA damage
is_a: IEV:0000071 ! Molecular event

[Term]
id: IEV:0001105
name: Activation of ATM by DNA damage
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0000165 ! p53 signaling pathway (through p21)
relationship: part_of IEV:0001107 ! p53 signaling pathway (through GADD45)
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0001106
name: G1 phase
def: "Progression through G1 phase, one of two 'gap' phases in the cell cycle; G1 is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis." [GO:0051318]
xref_analog: GO:0051318
is_a: IEV:0000078 ! Cell cycle arrest

[Term]
id: IEV:0001107
name: p53 signaling pathway (through GADD45)
is_a: IEV:0001103 ! p53 signaling pathway
relationship: part_of IEV:0000872 ! DNA repair

[Term]
id: IEV:0001108
name: Negative feedback regulation of p53 signaling pathway by MDM2
is_a: IEV:0000463 ! Negative regulation of p53 signaling pathway

[Term]
id: IEV:0001109
name: Proteasome degradation of p53
xref_analog: PubMed:10721693
xref_analog: PubMed:15021897
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0000868 ! p53 degradation signaling

[Term]
id: IEV:0001110
name: Gene expression by p53
is_a: IEV:0000182 ! Gene expression

[Term]
id: IEV:0001111
name: Gene expression of GADD45 by p53
is_a: IEV:0001110 ! Gene expression by p53
relationship: part_of IEV:0001107 ! p53 signaling pathway (through GADD45)

[Term]
id: IEV:0001112
name: Gene expression of 14-3-3 by p53
is_a: IEV:0001110 ! Gene expression by p53

[Term]
id: IEV:0001113
name: Gene expression of Mdm2 by p53
xref_analog: PubMed:12860999
is_a: IEV:0001110 ! Gene expression by p53
relationship: part_of IEV:0001108 ! Negative feedback regulation of p53 signaling pathway by MDM2

[Term]
id: IEV:0001114
name: p53 signaling pathway (through apoptotic factor)
is_a: IEV:0001103 ! p53 signaling pathway
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0001115
name: Gene expression of BAX by p53
is_a: IEV:0001604 ! Gene expression of apoptotic factor by p53

[Term]
id: IEV:0001116
name: Nuclear export of mRNA (GADD45)
is_a: IEV:0000909 ! Nuclear export of mRNA
relationship: part_of IEV:0001111 ! Gene expression of GADD45 by p53

[Term]
id: IEV:0001117
name: Transcription of GADD45 by p53
is_a: IEV:0001144 ! Transcription by p53
relationship: part_of IEV:0001111 ! Gene expression of GADD45 by p53

[Term]
id: IEV:0001118
name: Translation of GADD45
is_a: IEV:0000219 ! Translation
relationship: part_of IEV:0001111 ! Gene expression of GADD45 by p53

[Term]
id: IEV:0001119
name: Nuclear export of mRNA (MDM2)
xref_analog: PubMed:12860999
is_a: IEV:0000909 ! Nuclear export of mRNA
relationship: part_of IEV:0001113 ! Gene expression of Mdm2 by p53

[Term]
id: IEV:0001120
name: Transcription of MDM2 by p53
xref_analog: PubMed:12860999
is_a: IEV:0001144 ! Transcription by p53
relationship: part_of IEV:0001113 ! Gene expression of Mdm2 by p53

[Term]
id: IEV:0001121
name: Translation of Mdm2
xref_analog: PubMed:12860999
is_a: IEV:0000219 ! Translation
relationship: part_of IEV:0001113 ! Gene expression of Mdm2 by p53

[Term]
id: IEV:0001122
name: Regulation of p53 degradation signaling
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000868 ! p53 degradation signaling

[Term]
id: IEV:0001123
name: Negative regulation of p53 degradation signaling
is_a: IEV:0001122 ! Regulation of p53 degradation signaling
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0001124
name: Positive regulation of p53 degradation signaling
is_a: IEV:0001122 ! Regulation of p53 degradation signaling
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0001125
name: Nuclear export of mRNA (p21)
is_a: IEV:0000909 ! Nuclear export of mRNA
relationship: part_of IEV:0001080 ! Gene expression of p21 by p53
relationship: part_of IEV:0001158 ! Gene expression of p21 by Smad complex

[Term]
id: IEV:0001126
name: Transcription of p21 by p53
is_a: IEV:0001144 ! Transcription by p53
relationship: part_of IEV:0001080 ! Gene expression of p21 by p53

[Term]
id: IEV:0001127
name: Translation of p21
is_a: IEV:0000219 ! Translation
relationship: part_of IEV:0001080 ! Gene expression of p21 by p53
relationship: part_of IEV:0001158 ! Gene expression of p21 by Smad complex

[Term]
id: IEV:0001128
name: Nuclear export of mRNA (BAX)
is_a: IEV:0000909 ! Nuclear export of mRNA
is_a: IEV:0001115 ! Gene expression of BAX by p53

[Term]
id: IEV:0001129
name: Transcription of BAX by p53
is_a: IEV:0001115 ! Gene expression of BAX by p53
is_a: IEV:0001661 ! Transcription of apoptotic factor by p53

[Term]
id: IEV:0001130
name: Translation of BAX
is_a: IEV:0001115 ! Gene expression of BAX by p53
is_a: IEV:0001662 ! Translation of apoptotic factor

[Term]
id: IEV:0001131
name: Binding of Cdc2 (cdk1) and CyclinB
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000368 ! G2-M-phase transition pathway

[Term]
id: IEV:0001132
name: Binding of Cdc2 (Cdk1) and CyclinA
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000368 ! G2-M-phase transition pathway

[Term]
id: IEV:0001133
name: Phosphorylation of Cdc2 (Cdk1) by Cdk7
comment: Uniprot:P50613, Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000368 ! G2-M-phase transition pathway

[Term]
id: IEV:0001134
name: Dephosphorylation Cdk 2 by Cdc25C
def: " Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity.\nCATALYTIC ACTIVITY: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [XX:<new dbxref>]
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0000368 ! G2-M-phase transition pathway

[Term]
id: IEV:0001135
name: Phosphorylation of Cdc2 (Cdk1) by Wee1
def: "May act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDC2 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDC2 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDC2 occurs exclusively on Tyr-15 and phosphorylation of monomeric CDC2 does not occur.\nCATALYTIC ACTIVITY: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [UniProt:P30291]
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0001136 ! Negative regulation of G2-M-phase transition pathway

[Term]
id: IEV:0001136
name: Negative regulation of G2-M-phase transition pathway
is_a: IEV:0001137 ! Regulation of G2-M-phase transition pathway
is_a: IEV:0001404 ! Negative regulation of cell cycle regulation

[Term]
id: IEV:0001137
name: Regulation of G2-M-phase transition pathway
is_a: IEV:0001403 ! Regulation of cell cycle regulation
relationship: part_of IEV:0000368 ! G2-M-phase transition pathway

[Term]
id: IEV:0001138
name: Positive regulation of G2-M-phase transition pathway
is_a: IEV:0001137 ! Regulation of G2-M-phase transition pathway
is_a: IEV:0001405 ! Positive regulation of cell cycle regulation

[Term]
id: IEV:0001139
name: TGF beta super family signaling (through p15)
is_a: IEV:0000090 ! TGF beta super family signaling pathway
is_a: IEV:0000391 ! Negative regulation of G1-S-phase transition pathway

[Term]
id: IEV:0001140
name: TGF beta super family signaling (through p21)
is_a: IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0001141
name: Activation of p27 by Contact pressure
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0001152 ! Negative regulation of G1-S-phase transition pathway by contact pressure (through p27)

[Term]
id: IEV:0001142
name: Gene expression by Smad complex
is_a: IEV:0000182 ! Gene expression

[Term]
id: IEV:0001143
name: Gene expression of p15 by Smad complex
is_a: IEV:0001142 ! Gene expression by Smad complex
relationship: part_of IEV:0001139 ! TGF beta super family signaling (through p15)

[Term]
id: IEV:0001144
name: Transcription by p53
is_a: IEV:0000183 ! Transcription

[Term]
id: IEV:0001145
name: Transcription by Smad complex
is_a: IEV:0000183 ! Transcription

[Term]
id: IEV:0001146
name: Nuclear export of mRNA (p15)
is_a: IEV:0000909 ! Nuclear export of mRNA
relationship: part_of IEV:0001143 ! Gene expression of p15 by Smad complex

[Term]
id: IEV:0001147
name: Transcription of p15 by Smad complex
is_a: IEV:0001145 ! Transcription by Smad complex
relationship: part_of IEV:0001143 ! Gene expression of p15 by Smad complex

[Term]
id: IEV:0001148
name: Translation of p15
is_a: IEV:0000219 ! Translation
relationship: part_of IEV:0001143 ! Gene expression of p15 by Smad complex

[Term]
id: IEV:0001149
name: TGF beta super family signaling (through p16)
is_a: IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0001150
name: TGF beta super family signaling (through p27)
is_a: IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0001151
name: Activation of p21 by Contact pressure
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0001153 ! Negative regulation of G1-S-phase transition pathway by contact pressure (through p21)

[Term]
id: IEV:0001152
name: Negative regulation of G1-S-phase transition pathway by contact pressure (through p27)
is_a: IEV:0000391 ! Negative regulation of G1-S-phase transition pathway

[Term]
id: IEV:0001153
name: Negative regulation of G1-S-phase transition pathway by contact pressure (through p21)
is_a: IEV:0000391 ! Negative regulation of G1-S-phase transition pathway

[Term]
id: IEV:0001154
name: Translation of p16
is_a: IEV:0000219 ! Translation
relationship: part_of IEV:0001155 ! Gene expression of p16 by Smad complex

[Term]
id: IEV:0001155
name: Gene expression of p16 by Smad complex
is_a: IEV:0001142 ! Gene expression by Smad complex
relationship: part_of IEV:0001149 ! TGF beta super family signaling (through p16)

[Term]
id: IEV:0001156
name: Nuclear export of mRNA (p16)
is_a: IEV:0000909 ! Nuclear export of mRNA
relationship: part_of IEV:0001155 ! Gene expression of p16 by Smad complex

[Term]
id: IEV:0001157
name: Transcription of p16 by Smad complex
is_a: IEV:0001145 ! Transcription by Smad complex
relationship: part_of IEV:0001155 ! Gene expression of p16 by Smad complex

[Term]
id: IEV:0001158
name: Gene expression of p21 by Smad complex
is_a: IEV:0001142 ! Gene expression by Smad complex
relationship: part_of IEV:0001140 ! TGF beta super family signaling (through p21)

[Term]
id: IEV:0001159
name: Transcription of p21 by Smad complex
is_a: IEV:0001145 ! Transcription by Smad complex
relationship: part_of IEV:0001158 ! Gene expression of p21 by Smad complex

[Term]
id: IEV:0001160
name: Translation of p27
is_a: IEV:0000219 ! Translation
relationship: part_of IEV:0001162 ! Gene expression of p27 by Smad complex

[Term]
id: IEV:0001161
name: Transcription of p27 by Smad complex
is_a: IEV:0001145 ! Transcription by Smad complex
relationship: part_of IEV:0001162 ! Gene expression of p27 by Smad complex

[Term]
id: IEV:0001162
name: Gene expression of p27 by Smad complex
is_a: IEV:0001142 ! Gene expression by Smad complex
relationship: part_of IEV:0001150 ! TGF beta super family signaling (through p27)

[Term]
id: IEV:0001163
name: Nuclear export of mRNA (p27)
is_a: IEV:0000909 ! Nuclear export of mRNA
relationship: part_of IEV:0001162 ! Gene expression of p27 by Smad complex

[Term]
id: IEV:0001164
name: Hydrolysis of precursor Notch by convertase
xref_analog: PubMed:14985712
is_a: IEV:0001165 ! Hydrolysis in Golgi
relationship: part_of IEV:0001254 ! Notch receptor processing

[Term]
id: IEV:0001165
name: Hydrolysis in Golgi
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0001166
name: Translocation of Notch from the Golgi to plasma membrane
xref_analog: PubMed:14985712
is_a: IEV:0001167 ! Translocation from Golgi to plasma membrane
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001167
name: Translocation from Golgi to plasma membrane
def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [GO:0006893]
related_synonym: "Golgi to plasma membrane transport" []
related_synonym: "Golgi to plasma membrane vesicle-mediated transport" []
xref_analog: GO:0006893
is_a: IEV:0000009 ! Translocation
relationship: part_of IEV:0001941 ! Translocation from ER to plasma membrane

[Term]
id: IEV:0001168
name: Binding of Notch and ligand
xref_analog: PubMed:14985712
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001169
name: Hydrolysis of Notch by ADAM
def: "near the transmembrane domain" [XX:<new dbxref>]
xref_analog: PubMed:14985712
is_a: IEV:0000269 ! Hydrolysis in plasma membrane
relationship: part_of IEV:0001254 ! Notch receptor processing

[Term]
id: IEV:0001170
name: Hydrolysis of Notch by Presenilin
def: "within the transmembrane domain" [XX:<new dbxref>]
xref_analog: PubMed:14985712
is_a: IEV:0000269 ! Hydrolysis in plasma membrane
relationship: part_of IEV:0001254 ! Notch receptor processing

[Term]
id: IEV:0001171
name: Nuclear import of Notch (NIC) from the plasma membrane
xref_analog: PubMed:14985712
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001172
name: Binding of Notch (NIC) and CSL
xref_analog: PubMed:14985712
is_a: IEV:0001041 ! Binding in inner space of nucleus
is_a: IEV:0001174 ! Binding of Notch (NIC) and transcription factor

[Term]
id: IEV:0001173
name: Binding of Notch (NIC) and coactivator
xref_analog: PubMed:14985712
is_a: IEV:0001174 ! Binding of Notch (NIC) and transcription factor

[Term]
id: IEV:0001174
name: Binding of Notch (NIC) and transcription factor
xref_analog: GO:0007221
xref_analog: PubMed:14985712
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001175
name: Dissociation of CSL and corepressor
xref_analog: PubMed:14985712
is_a: IEV:0001042 ! Dissociation in nucleus
is_a: IEV:0001046 ! Dissociation in the inner space of the nuclear
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001176
name: Binding of CSL and responsive element
xref_analog: PubMed:14985712
is_a: IEV:0002098 ! Binding of transcriptional factor and responsive element
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001177
name: Transcription by CSL:Notch (NIC)
xref_analog: PubMed:14985712
is_a: IEV:0000183 ! Transcription
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001178
name: Regulation of Notch signaling pathway
def: "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GO:0008593]
xref_analog: GO:0008593
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001179
name: Negative regulation of Notch signaling pathway
def: "Any process that stops, prevents or reduces the rate, frequency or extent of the Notch signaling pathway." [GO:0045746]
xref_analog: GO:0045746
is_a: IEV:0001178 ! Regulation of Notch signaling pathway
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0001180
name: Positive regulation of Notch signaling pathway
def: "Any process that activates or increases the rate, frequency or extent of the Notch signaling pathway." [GO:0045747]
xref_analog: GO:0045747
is_a: IEV:0001178 ! Regulation of Notch signaling pathway
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0001181
name: Binding of Notch and Delta
xref_analog: PubMed:14985712
is_a: IEV:0001168 ! Binding of Notch and ligand

[Term]
id: IEV:0001182
name: Binding of Notch1 and Jagged1
xref_analog: PubMed:14985712
is_a: IEV:0002558 ! Binding of Notch and Serrate/Jagged

[Term]
id: IEV:0001183
name: Binding of Notch1 and Fringe
xref_analog: PubMed:14985712
is_a: IEV:0001184 ! Binding in Golgi
relationship: part_of IEV:0001192 ! Negative regulation of Jagged mediated Notch signaling pathway

[Term]
id: IEV:0001184
name: Binding in Golgi
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0001185
name: Binding of Notch and Fringe
xref_analog: PubMed:14985712
relationship: part_of IEV:0001190 ! Positive regulation of Delta mediated Notch signaling pathway

[Term]
id: IEV:0001186
name: Delta mediated Notch signaling pathway
xref_analog: PubMed:14985712
is_a: IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001187
name: Jagged mediated Notch signaling pathway
xref_analog: PubMed:14985712
is_a: IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001188
name: Regulation of Delta mediated Notch signaling pathway
is_a: IEV:0001178 ! Regulation of Notch signaling pathway
relationship: part_of IEV:0001186 ! Delta mediated Notch signaling pathway

[Term]
id: IEV:0001189
name: Negative regulation of Delta mediated Notch signaling pathway
is_a: IEV:0001179 ! Negative regulation of Notch signaling pathway
is_a: IEV:0001188 ! Regulation of Delta mediated Notch signaling pathway

[Term]
id: IEV:0001190
name: Positive regulation of Delta mediated Notch signaling pathway
is_a: IEV:0001180 ! Positive regulation of Notch signaling pathway
is_a: IEV:0001188 ! Regulation of Delta mediated Notch signaling pathway

[Term]
id: IEV:0001191
name: Regulation of Jagged mediated Notch signaling pathway
is_a: IEV:0001178 ! Regulation of Notch signaling pathway
relationship: part_of IEV:0001187 ! Jagged mediated Notch signaling pathway

[Term]
id: IEV:0001192
name: Negative regulation of Jagged mediated Notch signaling pathway
is_a: IEV:0001179 ! Negative regulation of Notch signaling pathway
is_a: IEV:0001191 ! Regulation of Jagged mediated Notch signaling pathway

[Term]
id: IEV:0001193
name: Positive regulation of Jagged mediated Notch signaling pathway
is_a: IEV:0001180 ! Positive regulation of Notch signaling pathway
is_a: IEV:0001191 ! Regulation of Jagged mediated Notch signaling pathway

[Term]
id: IEV:0001194
name: Binding of Mint and CSL
xref_analog: PubMed:14985712
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001179 ! Negative regulation of Notch signaling pathway
relationship: part_of IEV:0001189 ! Negative regulation of Delta mediated Notch signaling pathway
relationship: part_of IEV:0001192 ! Negative regulation of Jagged mediated Notch signaling pathway

[Term]
id: IEV:0001195
name: Activation of Deltex [Mammalian]
def: "Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity." [Uniprot:Q86Y01]
xref_analog: PubMed:14985712
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0001179 ! Negative regulation of Notch signaling pathway
relationship: part_of IEV:0001189 ! Negative regulation of Delta mediated Notch signaling pathway
relationship: part_of IEV:0001192 ! Negative regulation of Jagged mediated Notch signaling pathway

[Term]
id: IEV:0001196
name: Activation of Deltex [Drosophila]
def: "Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as an ubiquitin ligase protein in the Notch pathway." [Uniprot:Q23985]
xref_analog: PubMed:14985712
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0001179 ! Negative regulation of Notch signaling pathway
relationship: part_of IEV:0001180 ! Positive regulation of Notch signaling pathway

[Term]
id: IEV:0001197
name: Activation of Numb [Mammalian]
xref_analog: PubMed:14985712
relationship: part_of IEV:0001179 ! Negative regulation of Notch signaling pathway
relationship: part_of IEV:0001189 ! Negative regulation of Delta mediated Notch signaling pathway
relationship: part_of IEV:0001192 ! Negative regulation of Jagged mediated Notch signaling pathway

[Term]
id: IEV:0001198
name: Complex formation of BCR receptor complex and coreceptor
related_synonym: "BCR receptor complex and coreceptor complex formation" []
xref_analog: PubMed:14632637
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0001199
name: Actomyosin structure organization and biogenesis
def: "The assembly and arrangement of cytoskeletal structures containing both actin and myosin. The myosin may be organized into filaments." [GO:0031032]
xref_analog: GO:0031032
is_a: IEV:0000092 ! Cytoskeleton organization and biogenesis

[Term]
id: IEV:0001200
name: Integrin signaling pathway (through PI3K, Vav and Rac)
xref_analog: KEGG:hsa04510
relationship: part_of IEV:0000093 ! Lamellipodium biogenesis
relationship: part_of IEV:0000094 ! Membrane ruffling
relationship: part_of IEV:0000104 ! Cell migration
relationship: part_of IEV:0000124 ! Integrin signaling pathway

[Term]
id: IEV:0001201
name: Binding of Estrogen and Estrogen receptor
xref_analog: PubMed:11559590
xref_analog: PubMed:15385571
is_a: IEV:0000013 ! Binding in cytosol
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001202
name: Translocation of Estrogen from extracellular to cytosol
xref_analog: PubMed:15385571
is_a: IEV:0001203 ! Translocation from extracellular to cytosol
relationship: part_of IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001203
name: Translocation from extracellular to cytosol
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0001204
name: Binding of Estrogen receptor and SWI/SNF
xref_analog: PubMed:11559590
is_a: IEV:0001208 ! Binding of Estrogen receptor and transcriptional factor

[Term]
id: IEV:0001205
name: Nuclear import of Estrogen
xref_analog: PubMed:15385571
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001206
name: Complex formation of Estrogen receptor
related_synonym: "Estrogen receptor complex formation" []
xref_analog: PubMed:15385571
is_a: IEV:0000013 ! Binding in cytosol
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001207
name: Binding of Estrogen receptor and responsive element
xref_analog: PubMed:11559590
is_a: IEV:0002098 ! Binding of transcriptional factor and responsive element
relationship: part_of IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001208
name: Binding of Estrogen receptor and transcriptional factor
xref_analog: PubMed:11559590
is_a: IEV:0001041 ! Binding in inner space of nucleus
is_a: IEV:0001215 ! Transcription factor complex formation with Estrogen receptor

[Term]
id: IEV:0001209
name: Binding of Estrogen receptor and p160
xref_analog: PubMed:11559590
is_a: IEV:0001208 ! Binding of Estrogen receptor and transcriptional factor

[Term]
id: IEV:0001210
name: Binding of Estrogen receptor and cyclin D1
xref_analog: PubMed:11559590
is_a: IEV:0001208 ! Binding of Estrogen receptor and transcriptional factor

[Term]
id: IEV:0001211
name: Binding of Estrogen receptor and MTA-1
xref_analog: PubMed:11559590
is_a: IEV:0001208 ! Binding of Estrogen receptor and transcriptional factor

[Term]
id: IEV:0001212
name: Binding of Estrogen receptor and corepressor
xref_analog: PubMed:11559590
is_a: IEV:0001208 ! Binding of Estrogen receptor and transcriptional factor

[Term]
id: IEV:0001213
name: Binding of Estrogen receptor and NCoR
xref_analog: PubMed:11559590
is_a: IEV:0001212 ! Binding of Estrogen receptor and corepressor

[Term]
id: IEV:0001214
name: Binding of Estrogen receptor and SMRT
xref_analog: PubMed:11559590
is_a: IEV:0001212 ! Binding of Estrogen receptor and corepressor

[Term]
id: IEV:0001215
name: Transcription factor complex formation with Estrogen receptor
xref_analog: PubMed:11136970
xref_analog: PubMed:11559590
xref_analog: PubMed:12040178
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001216
name: Binding of Transcription factor complex and CBP
xref_analog: PubMed:11559590
is_a: IEV:0001215 ! Transcription factor complex formation with Estrogen receptor

[Term]
id: IEV:0001217
name: Binding of Transcription factor complex and HDAC
xref_analog: PubMed:11559590
is_a: IEV:0001215 ! Transcription factor complex formation with Estrogen receptor

[Term]
id: IEV:0001218
name: Binding of Transcription factor complex and pCAF
xref_analog: PubMed:11559590
is_a: IEV:0001215 ! Transcription factor complex formation with Estrogen receptor

[Term]
id: IEV:0001219
name: Binding of Transcription factor complex and p300
xref_analog: PubMed:11559590
is_a: IEV:0001215 ! Transcription factor complex formation with Estrogen receptor

[Term]
id: IEV:0001220
name: Binding of Transcription factor complex and HAT
xref_analog: PubMed:11559590
is_a: IEV:0001215 ! Transcription factor complex formation with Estrogen receptor

[Term]
id: IEV:0001221
name: Transcription by Estrogen receptor
xref_analog: PubMed:11559590
is_a: IEV:0000183 ! Transcription
relationship: part_of IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001222
name: Src activation signaling
is_a: IEV:0001589 ! Src family activation signaling

[Term]
id: IEV:0001223
name: Binding of Src and Estrogen receptor:MNAR
xref_analog: PubMed:12415108
is_a: IEV:0000186 ! Binding in unidentified cellular location
relationship: part_of IEV:0001313 ! Src activation signaling (through Estrogen receptor)

[Term]
id: IEV:0001224
name: Binding of Estrogen receptor and MNAR
xref_analog: PubMed:12415108
is_a: IEV:0000186 ! Binding in unidentified cellular location
relationship: part_of IEV:0001313 ! Src activation signaling (through Estrogen receptor)

[Term]
id: IEV:0001225
name: Binding of Estrogen receptor alpha and MNAR
xref_analog: PubMed:12415108
is_a: IEV:0001224 ! Binding of Estrogen receptor and MNAR

[Term]
id: IEV:0001226
name: Binding of Estrogen receptor beta and MNAR
xref_analog: PubMed:12415108
is_a: IEV:0001224 ! Binding of Estrogen receptor and MNAR

[Term]
id: IEV:0001227
name: PI3K activation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling

[Term]
id: IEV:0001228
name: Binding of Estrogen receptor alpha and p85
xref_analog: PubMed:11029009
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001978 ! PI3K activation signaling (through Estrogen receptor)

[Term]
id: IEV:0001229
name: Binding of Estrogen and Estrogen receptor alpha
xref_analog: PubMed:11559590
is_a: IEV:0001201 ! Binding of Estrogen and Estrogen receptor

[Term]
id: IEV:0001230
name: Binding of Estrogen and Estrogen receptor beta
xref_analog: PubMed:11559590
is_a: IEV:0001201 ! Binding of Estrogen and Estrogen receptor
relationship: part_of IEV:0001978 ! PI3K activation signaling (through Estrogen receptor)

[Term]
id: IEV:0001231
name: Steroid receptor signaling pathway
def: "Any series of molecular signals generated as a consequence of a steroid hormone binding to its receptor. " [GO:0030518]
related_synonym: "steroid hormone receptor signaling pathway" []
xref_analog: GO:0030518
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0001232
name: Androgen receptor signaling pathway
def: "Any series of molecular signals generated as a consequence of an androgen binding to its receptor." [GO:0030521]
xref_analog: GO:0030521
is_a: IEV:0001231 ! Steroid receptor signaling pathway

[Term]
id: IEV:0001233
name: TPO signaling pathway (JAK2, STAT3)
is_a: IEV:0000044 ! JAK STAT pathway
relationship: part_of IEV:0000120 ! TPO signaling pathway

[Term]
id: IEV:0001234
name: TPO signaling pathway (through Sos, Ras and Erk cascade)
relationship: part_of IEV:0000120 ! TPO signaling pathway

[Term]
id: IEV:0001235
name: TPO signaling pathway (through PI3K, PLCgamma and PKC)
relationship: part_of IEV:0000120 ! TPO signaling pathway

[Term]
id: IEV:0001236
name: Binding of Glutamate and NMDA receptor
xref_analog: PubMed:12536131
xref_analog: PubMed:14556714
relationship: part_of IEV:0000125 ! Glutamate receptor signaling pathway

[Term]
id: IEV:0001237
name: Binding of Glutamate and AMPA receptor
xref_analog: PubMed:14556714
relationship: part_of IEV:0000125 ! Glutamate receptor signaling pathway

[Term]
id: IEV:0001238
name: Translocation of sodium ion from extracellular to cytosol (through AMPA receptor)
xref_analog: PubMed:14556714
is_a: IEV:0001203 ! Translocation from extracellular to cytosol
relationship: part_of IEV:0000125 ! Glutamate receptor signaling pathway

[Term]
id: IEV:0001239
name: Changes in polarization state of the membrane
is_a: IEV:0000744 ! Neurological process

[Term]
id: IEV:0001240
name: Depolarization state of the postsynaptic cell
xref_analog: PubMed:14556714
is_a: IEV:0001241 ! Changes in polarization state of postsynaptic cell membrane
relationship: part_of IEV:0000125 ! Glutamate receptor signaling pathway

[Term]
id: IEV:0001241
name: Changes in polarization state of postsynaptic cell membrane
is_a: IEV:0001239 ! Changes in polarization state of the membrane

[Term]
id: IEV:0001242
name: Dissociation of magnesium ion and NMDA receptor
xref_analog: PubMed:14556714
is_a: IEV:0000665 ! Dissociation in plasma membrane
relationship: part_of IEV:0001247 ! Cytosolic calcium ion concentration elevation (through Glutamate receptor)

[Term]
id: IEV:0001243
name: Translocation of calcium and sodium ion from extracellular to cytosol (through NMDA receptor)
xref_analog: PubMed:14556714
is_a: IEV:0001203 ! Translocation from extracellular to cytosol
relationship: part_of IEV:0001247 ! Cytosolic calcium ion concentration elevation (through Glutamate receptor)

[Term]
id: IEV:0001244
name: Long-Term Potentiation
xref_analog: KEGG:hsa04720
xref_analog: PubMed:14556714
is_a: IEV:0000744 ! Neurological process

[Term]
id: IEV:0001245
name: Binding of calcium ion and calmodulin
xref_analog: PubMed:14556714
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001303 ! Calcineurin activation signaling
relationship: part_of IEV:0001304 ! CaMKII activation signaling

[Term]
id: IEV:0001246
name: Cytosolic calcium ion concentration elevation
def: "Any process that increases the concentration of calcium ions in the cytosol." [GO:0007204]
related_synonym: "elevation of calcium ion concentration in cytosol" [GO:0007204]
related_synonym: "elevation of cytosolic calcium ion concentration" [GO:0007204]
xref_analog: GO:0007204
is_a: IEV:0000771 ! Change in material concentration

[Term]
id: IEV:0001247
name: Cytosolic calcium ion concentration elevation (through Glutamate receptor)
xref_analog: PubMed:14556714
is_a: IEV:0001246 ! Cytosolic calcium ion concentration elevation
relationship: part_of IEV:0000125 ! Glutamate receptor signaling pathway

[Term]
id: IEV:0001248
name: Binding of calcium calmodulin and CaMKII
xref_analog: PubMed:14556714
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001304 ! CaMKII activation signaling

[Term]
id: IEV:0001249
name: Cytosolic cation ion concentration decline (through cGMP activated cation ion channel)
is_a: IEV:0001031 ! Cytosolic cation ion concentration decline
relationship: part_of IEV:0000723 ! Heterotrimeric GPCR signaling pathway (through photon, rhodopsin, G alpha t and cGMP PDE)

[Term]
id: IEV:0001250
name: Translocation of calcium ion from the cytosol to the extracellular
is_a: IEV:0001251 ! Translocation from cytosol to extracellular
relationship: part_of IEV:0001249 ! Cytosolic cation ion concentration decline (through cGMP activated cation ion channel)

[Term]
id: IEV:0001251
name: Translocation from cytosol to extracellular
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0001252
name: Binding of TCR-CD3 complex and non-receptor tyrosine kinase
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0001479 ! CD28 signaling

[Term]
id: IEV:0001253
name: Phosphorylation of CD3 zeta by non-receptor tyrosine kinase
xref_analog: PubMed:12040176
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
relationship: part_of IEV:0000280 ! CD4 T cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0001254
name: Notch receptor processing
def: "The series of successive proteolytic cleavage events that take place after a Notch receptor binds a ligand, and which lead to the release of the Notch Intracellular Domain (NICD), which is the active form of the receptor." [GO:0007220]
xref_analog: GO:0007220
xref_analog: PubMed:14985712
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000164 ! Notch signaling pathway

[Term]
id: IEV:0001255
name: Receptor recycling
def: "The process by which receptor molecules are returned to an active state and in an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal." [GO:0001881]
xref_analog: GO:0001881
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0001256
name: Complex formation of TGF beta superfamily receptor
def: "The aggregation and bonding together of a type II transforming growth factor beta (TGFbeta) receptor dimer with a type I TGFbeta receptor dimer, following ligand binding, to form a heterotetrameric TGFbeta receptor complex." [GO:0007181]
related_synonym: "TGF beta superfamily receptor complex formation" []
xref_analog: GO:0007181
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway

[Term]
id: IEV:0001257
name: PDGF signaling pathway
def: "The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands." [GO:0048008]
related_synonym: "PDGF receptor signaling pathway" [GO:0048008]
related_synonym: "PDGFR signaling pathway" [GO:0048008]
related_synonym: "platelet-derived growth factor receptor signaling pathway" [GO:0048008]
xref_analog: GO:0048008
is_a: IEV:0000830 ! RTK signaling pathway

[Term]
id: IEV:0001258
name: Ras mediated signaling
def: "A series of molecular signals within the cell that are mediated by a member of the Ras family of proteins switching to a GTP-bound active state." [GO:0007265]
related_synonym: "Ras mediated signal transduction" [GO:0007265]
related_synonym: "Ras protein signal transduction" [GO:0007265]
xref_analog: GO:0007265
is_a: IEV:0000676 ! Small GTPase mediated signaling

[Term]
id: IEV:0001259
name: Rac mediated signaling
def: "A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state." [GO:0016601]
related_synonym: "Rac mediated signal transduction" [GO:0016601]
related_synonym: "Rac protein signal transduction" [GO:0016601]
xref_analog: GO:0016601
is_a: IEV:0000676 ! Small GTPase mediated signaling

[Term]
id: IEV:0001260
name: Rho mediated signaling
def: "A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GO:0007266]
related_synonym: "Rho mediated signal transduction" [GO:0007266]
related_synonym: "Rho protein signal transduction" [GO:0007266]
xref_analog: GO:0007266
is_a: IEV:0000676 ! Small GTPase mediated signaling
relationship: part_of IEV:0000616 ! Integrin signaling pathway (through Rho)

[Term]
id: IEV:0001261
name: Rho-p160-myosin phosphatase signaling
xref_analog: KEGG:hsa04510
xref_analog: KEGG:hsa04810
xref_analog: KEGG:mmu04810
xref_analog: KEGG:rno04810
is_a: IEV:0001260 ! Rho mediated signaling

[Term]
id: IEV:0001262
name: Rho-PI5K signaling
xref_analog: KEGG:hsa04510
is_a: IEV:0001260 ! Rho mediated signaling

[Term]
id: IEV:0001263
name: Ral mediated signaling
def: "A series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state." [GO:0032484]
related_synonym: "Ral protein signal transduction" []
xref_analog: GO:0032484
is_a: IEV:0000676 ! Small GTPase mediated signaling

[Term]
id: IEV:0001264
name: I-kappaB degradation signaling
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
is_a: IEV:0001269 ! Positive regulation of IKK-NF-kappaB signaling

[Term]
id: IEV:0001265
name: Proteasome degradation of I-kappaB by 26S proteasome
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0001264 ! I-kappaB degradation signaling

[Term]
id: IEV:0001266
name: Ubiquitination of I-kappaB
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0001264 ! I-kappaB degradation signaling

[Term]
id: IEV:0001267
name: Regulation of IKK-NF-kappaB signaling
def: "Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade." [GO:0043122]
related_synonym: "regulation of I-kappaB kinase/NF-kappaB cascade" []
xref_analog: GO:0043122
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000208 ! IKK-NF-kappaB cascade

[Term]
id: IEV:0001268
name: Negative regulation of IKK-NF-kappaB signaling
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade." [GO:0043124]
related_synonym: "downregulation of I-kappaB kinase/NF-kappaB cascade" []
related_synonym: "negative regulation of I-kappaB kinase/NF-kappaB cascade" []
xref_analog: GO:0043124
is_a: IEV:0001267 ! Regulation of IKK-NF-kappaB signaling
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0001269
name: Positive regulation of IKK-NF-kappaB signaling
def: "Any process that activates or increases the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade." [GO:0043123]
related_synonym: "positive regulation of I-kappaB kinase/NF-kappaB cascade" []
related_synonym: "upregulation of I-kappaB kinase/NF-kappaB cascade" []
xref_analog: GO:0043123
is_a: IEV:0001267 ! Regulation of IKK-NF-kappaB signaling
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0001270
name: Phosphorylation of STAT by MAPK
xref_analog: GO:0042501
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000044 ! JAK STAT pathway

[Term]
id: IEV:0001271
name: Complex formation of BCR
related_synonym: "BCR complex formation" []
xref_analog: PubMed:14632637
relationship: part_of IEV:0001198 ! Complex formation of BCR receptor complex and coreceptor

[Term]
id: IEV:0001272
name: Complex formation of B cell coreceptor
related_synonym: "B cell coreceptor complex formation" []
xref_analog: PubMed:14632637
relationship: part_of IEV:0001198 ! Complex formation of BCR receptor complex and coreceptor

[Term]
id: IEV:0001273
name: Regulation of B cell receptor signaling
def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GO:0050855]
xref_analog: GO:0050855
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000107 ! B cell receptor signaling pathway

[Term]
id: IEV:0001274
name: Negative regulation of B cell receptor signaling
def: "Any process that stops, prevents or reduces the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GO:0050859]
xref_analog: GO:0050859
is_a: IEV:0001273 ! Regulation of B cell receptor signaling
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0001275
name: Positive regulation of B cell receptor signaling
def: "Any process that activates or increases the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GO:0050861]
xref_analog: GO:0050861
is_a: IEV:0001273 ! Regulation of B cell receptor signaling
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0001276
name: Negative regulation of B cell receptor signaling (through CD72 and SHP-1)
xref_analog: PubMed:14632637
is_a: IEV:0001274 ! Negative regulation of B cell receptor signaling

[Term]
id: IEV:0001277
name: Complex formation of IgM and Ig alpha:beta
related_synonym: "IgM and Ig alpha:beta complex formation" []
xref_analog: PubMed:14632637
relationship: part_of IEV:0001271 ! Complex formation of BCR

[Term]
id: IEV:0001278
name: Binding of antigen and BCR complex
xref_analog: PubMed:14632637
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0001279
name: Phosphorylation of Ig alpha:beta by non-receptor tyrosine kinase
def: "the immunoglobulin (Ig) and Ig cytoplasmic tails are phosphorylated on the immunoreceptor tyrosine-based activation motif (ITAM) tyrosines by Src-family tyrosine kinases (SFTKs) and/or Syk" [PubMed:14632637]
xref_analog: PubMed:14632637
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0001280
name: Phosphorylation of Ig alpha:beta by Lyn
xref_analog: PubMed:14632637
is_a: IEV:0001282 ! Phosphorylation of Ig alpha:beta by Src family

[Term]
id: IEV:0001281
name: Phosphorylation of Ig alpha:beta by Syk
xref_analog: PubMed:14632637
is_a: IEV:0001279 ! Phosphorylation of Ig alpha:beta by non-receptor tyrosine kinase

[Term]
id: IEV:0001282
name: Phosphorylation of Ig alpha:beta by Src family
xref_analog: PubMed:14632637
is_a: IEV:0001279 ! Phosphorylation of Ig alpha:beta by non-receptor tyrosine kinase

[Term]
id: IEV:0001283
name: Binding of Ig alpha and Syk
def: "he B-cell linker protein (BLNK) binds to tyrosine 204 of Ig alpha." [PubMed:14632637]
xref_analog: PubMed:14632637
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0001284
name: Binding of Ig alpha and BLNK
xref_analog: PubMed:14632637
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0001285
name: Binding of BLNK and BtK
xref_analog: PubMed:14632637
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0002310 ! Binding of BLNK, BTK, PLC gamma, Vav and PIP3

[Term]
id: IEV:0001286
name: Binding of BLNK and PLC gamma
xref_analog: PubMed:14632637
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0002310 ! Binding of BLNK, BTK, PLC gamma, Vav and PIP3

[Term]
id: IEV:0001287
name: Binding of tyrosine-phosphorylated protein and PLC
is_obsolete: true

[Term]
id: IEV:0001288
name: Phosphorylation of PLC by non-receptor tyrosine kinase
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000471 ! PLC signaling

[Term]
id: IEV:0001289
name: Binding of DAG and PKC theta and active conformational change of PKC theta
xref_analog: PubMed:15343367
is_a: IEV:0003426 ! Binding of DAG and nPKC and active conformational change of nPKC
relationship: part_of IEV:0001391 ! PKC theta activation signaling

[Term]
id: IEV:0001290
name: Phosphorylation of PLC gamma by Btk
def: "B-cell" [PubMed:14632637]
xref_analog: PubMed:14632637
is_a: IEV:0000286 ! Phosphorylation of PLC gamma by non-receptor tyrosine kinase

[Term]
id: IEV:0001291
name: Binding of tyrosine-phosphorylated protein and PLC gamma
is_obsolete: true

[Term]
id: IEV:0001292
name: Phosphorylation of Ig alpha:beta by Fyn
xref_analog: PubMed:14632637
is_a: IEV:0001282 ! Phosphorylation of Ig alpha:beta by Src family

[Term]
id: IEV:0001293
name: Phosphorylation of Ig alpha:beta by Blk
xref_analog: PubMed:14632637
is_a: IEV:0001282 ! Phosphorylation of Ig alpha:beta by Src family

[Term]
id: IEV:0001294
name: B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
xref_analog: PubMed:14632637
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000107 ! B cell receptor signaling pathway

[Term]
id: IEV:0001295
name: B cell receptor signaling (through Ras and ERK cascade)
xref_analog: PubMed:14632637
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000107 ! B cell receptor signaling pathway

[Term]
id: IEV:0001296
name: B cell receptor signaling (through Vav and Rac)
xref_analog: PubMed:14632637
relationship: part_of IEV:0000092 ! Cytoskeleton organization and biogenesis
relationship: part_of IEV:0000107 ! B cell receptor signaling pathway

[Term]
id: IEV:0001297
name: Binding of BLNK and Grb2
xref_analog: PubMed:14632637
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001295 ! B cell receptor signaling (through Ras and ERK cascade)

[Term]
id: IEV:0001298
name: B cell receptor signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000002 ! Cell differentiation
relationship: part_of IEV:0000076 ! Cell proliferation
relationship: part_of IEV:0000107 ! B cell receptor signaling pathway

[Term]
id: IEV:0001299
name: Binding of BLNK and Vav
xref_analog: PubMed:14632637
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001296 ! B cell receptor signaling (through Vav and Rac)

[Term]
id: IEV:0001300
name: Rac activation signaling
is_a: IEV:0001301 ! Small GTPase activation signaling

[Term]
id: IEV:0001301
name: Small GTPase activation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling

[Term]
id: IEV:0001302
name: Calcium ion dependent protein activation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling

[Term]
id: IEV:0001303
name: Calcineurin activation signaling
is_a: IEV:0001302 ! Calcium ion dependent protein activation signaling
relationship: part_of IEV:0000482 ! CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0001304
name: CaMKII activation signaling
is_a: IEV:0001302 ! Calcium ion dependent protein activation signaling
relationship: part_of IEV:0000125 ! Glutamate receptor signaling pathway

[Term]
id: IEV:0001305
name: Binding of calcium calmodulin and calcineurin
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001303 ! Calcineurin activation signaling

[Term]
id: IEV:0001306
name: Binding of calcium ion and calcineurin
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001303 ! Calcineurin activation signaling

[Term]
id: IEV:0001307
name: Activation of NF-kappaB by Src family
related_synonym: "NF-kappaB activation" []
xref_analog: PubMed:14632637
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0001298 ! B cell receptor signaling (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0001308
name: Transcription by NF-kappaB
is_a: IEV:0000183 ! Transcription
relationship: part_of IEV:0000783 ! Gene expression by NF-kappaB

[Term]
id: IEV:0001309
name: Dephosphorylation of NF-AT by calcineurin
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0001310
name: Nuclear import of NF-AT
def: "The directed movement of NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors, from the cytoplasm into the nucleus. NFAT proteins are dephosphorylated in the cytoplasm by activated calcineurin, which leads to their translocation across the nuclear membrane." [GO:0051531]
related_synonym: "NFAT protein import into nucleus" []
related_synonym: "NFAT protein nuclear translocation" []
related_synonym: "NFAT protein nucleus import" []
related_synonym: "NFAT protein transport from cytoplasm to nucleus" []
xref_analog: GO:0051531
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0001311
name: Nuclear import of calcineurin
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0001312
name: Transcription by NF-AT
is_a: IEV:0000183 ! Transcription
relationship: part_of IEV:0001294 ! B cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0001313
name: Src activation signaling (through Estrogen receptor)
xref_analog: PubMed:12415108
is_a: IEV:0001222 ! Src activation signaling

[Term]
id: IEV:0001314
name: Lymphocyte differentiation
def: "The process whereby a relatively unspecialized precursor cell acquires specialized features of B-cells, T-cells, or natural killer cells." [GO:0030098]
xref_analog: GO:0030098
is_a: IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0001315
name: Lymphocyte proliferation
def: "The rapid expansion of a lymphocyte population by cell division." [GO:0046651]
xref_analog: GO:0046651
is_a: IEV:0000076 ! Cell proliferation

[Term]
id: IEV:0001316
name: G2 phase
def: "Progression through G2 phase, one of two 'gap' phases in the cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." [GO:0051319]
xref_analog: GO:0051319
is_a: IEV:0000078 ! Cell cycle arrest

[Term]
id: IEV:0001317
name: Cell growth and/or maintenance
def: "Any process required for the survival and growth of a cell." [GO:0008151]
xref_analog: GO:0008151
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0001319
name: Cell communication
def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GO:0007154]
xref_analog: GO:0007154
is_a: IEV:0000069 ! Cellular event

[Term]
id: IEV:0001320
name: Cell organization and biogenesis
def: "The processes involved in the assembly and arrangement of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GO:0016043]
related_synonym: "cellular component organization and biogenesis" [GO:0016043]
xref_analog: GO:0016043
is_a: IEV:0001317 ! Cell growth and/or maintenance

[Term]
id: IEV:0001321
name: Cytoplasm organization and biogenesis
def: "The assembly and arrangement of the cytoplasm and its components." [GO:0007028]
xref_analog: GO:0007028
is_a: IEV:0001320 ! Cell organization and biogenesis

[Term]
id: IEV:0001322
name: Organelle organization and biogenesis
def: "The assembly and arrangement of any organelle within a cell" [GO:0006996]
xref_analog: GO:0006996
is_a: IEV:0001320 ! Cell organization and biogenesis

[Term]
id: IEV:0001323
name: Actin cytoskeleton organization and biogenesis
def: "The assembly and arrangement of cytoskeletal structures comprising actin filaments and their associated proteins." [GO:0030036]
xref_analog: GO:0030036
is_a: IEV:0000092 ! Cytoskeleton organization and biogenesis

[Term]
id: IEV:0001324
name: Actin filament organization
def: "Control of the spatial distribution of actin filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GO:0007015]
xref_analog: GO:0007015
is_a: IEV:0001323 ! Actin cytoskeleton organization and biogenesis

[Term]
id: IEV:0001325
name: Cellular morphogenesis
def: "Any process that modulates the mass, volume, or shape of a cell." [GO:0000902]
xref_analog: GO:0000902
is_a: IEV:0001320 ! Cell organization and biogenesis

[Term]
id: IEV:0001326
name: Permeabilization of mitochondria and Translocation of Aif from mitochondria to cytosol
is_a: IEV:0000985 ! Translocation from mitochondria to cytosol
relationship: part_of IEV:0001011 ! AIF mediated signaling

[Term]
id: IEV:0001327
name: Multicellular organismal process
def: "The biological processes, occurring at the level of the organism, pertinent to the function of the organism." [GO:0032501]
related_synonym: "Organismal physiological process" [GO:0050874]
xref_analog: GO:0032501
xref_analog: GO:0050874
is_a: IEV:0000082 ! Organism event
is_a: IEV:0001330 ! Physiological event

[Term]
id: IEV:0001328
name: Rhythmic behavior
def: "The specific actions or reactions of an organism that recur with measured regularity." [GO:0007622]
xref_analog: GO:0007622
is_a: IEV:0000106 ! Behavior

[Term]
id: IEV:0001329
name: Seed development
def: "Processes aimed at the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves." [GO:0048316]
xref_analog: GO:0048316
is_a: IEV:0000083 ! Development

[Term]
id: IEV:0001330
name: Physiological event
def: "Those processes specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms." [GO:0007582]
related_synonym: "Physiological process" [GO:0007582]
xref_analog: GO:0007582
is_a: IEV:0000003 ! Biological event

[Term]
id: IEV:0001331
name: Homeostasis
def: "Any of the processes involved in the maintenance of an internal equilibrium within an organism or cell." [GO:0042592]
xref_analog: GO:0042592
is_a: IEV:0001330 ! Physiological event

[Term]
id: IEV:0001332
name: Response to stimulus
def: "A change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a stimulus." [GO:0050896]
xref_analog: GO:0050896
is_a: IEV:0001330 ! Physiological event

[Term]
id: IEV:0001333
name: Response to biotic stimulus
def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a biotic stimulus." [GO:0009607]
xref_analog: GO:0009607
is_a: IEV:0001332 ! Response to stimulus

[Term]
id: IEV:0001335
name: Response to endogenous stimulus
def: "A change in state or activity of a cell or an organism as a result of the perception of an endogenous stimulus." [GO:0009719]
xref_analog: GO:0009719
is_a: IEV:0001332 ! Response to stimulus

[Term]
id: IEV:0001336
name: Response to external stimulus
def: "A change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of an external stimulus." [GO:0009605]
xref_analog: GO:0009605
is_a: IEV:0001332 ! Response to stimulus

[Term]
id: IEV:0001337
name: Response to stress
def: "A change in state or activity of an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) that occurs in response to stress, usually, but not necessarily exogenous (e.g. temperature, humidity, ionizing radiation).\nTerm Lineage" [GO:0006950]
xref_analog: GO:0006950
is_a: IEV:0001332 ! Response to stimulus

[Term]
id: IEV:0001338
name: Flower formation
def: "The process that gives rise to the flower. This process pertains to the initial formation of a structure from unspecified parts." [GO:0048460]
xref_analog: GO:0048460
relationship: part_of IEV:0000577 ! Flower morphogenesis

[Term]
id: IEV:0001339
name: Wood development
alt_id: IEV:0000395
related_synonym: "Wood formation" []
is_a: IEV:0000575 ! Post-embryonic morphogenesis

[Term]
id: IEV:0001340
name: Bud development
alt_id: IEV:0000399
related_synonym: "Bud formation" []
is_a: IEV:0000575 ! Post-embryonic morphogenesis

[Term]
id: IEV:0001341
name: Response to wounding
def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of damage to the organism." [GO:0009611]
xref_analog: GO:0009611
is_a: IEV:0001336 ! Response to external stimulus

[Term]
id: IEV:0001342
name: Wound healing
def: "The series of events that restore integrity to a damaged tissue, following an injury." [GO:0042060]
xref_analog: GO:0042060
is_a: IEV:0001341 ! Response to wounding

[Term]
id: IEV:0001343
name: Binding of IL-2 and IL-2 receptor and conformational change of receptors
def: "Combining with interleukin-2 to initiate a change in cell activity." [GO:0004911]
xref_analog: GO:0004911
xref_analog: GO:0005134
xref_analog: PubMed:10920190
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors
relationship: part_of IEV:0000136 ! IL2 signaling (JAK1, JAK3, STAT5)

[Term]
id: IEV:0001344
name: Binding of IL3 and IL3R complex
def: "Combining with interleukin-3 to initiate a change in cell activity." [GO:0004912]
xref_analog: GO:0004912
xref_analog: GO:0005135
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors
relationship: part_of IEV:0000135 ! IL3 signaling pathway (JAK1, JAK2, STAT5)

[Term]
id: IEV:0001345
name: Binding of IL4 and IL4R complex
def: "Combining with interleukin-4 to initiate a change in cell activity." [GO:0004913]
xref_analog: GO:0004913
xref_analog: GO:0005136
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors
relationship: part_of IEV:0000134 ! IL4 signaling pathway (JAK1, JAK3, STAT6)

[Term]
id: IEV:0001346
name: Binding of IL7 and IL7R
def: "Combining with interleukin-7 to initiate a change in cell activity." [GO:0019982]
xref_analog: GO:0005139
xref_analog: GO:0019982
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors
relationship: part_of IEV:0000140 ! IL7 signaling (JAK1, JAK3, STAT5)

[Term]
id: IEV:0001347
name: Binding of IL-12 and IL-12 receptor and conformational change of receptors
def: "Combining with interleukin-12 to initiate a change in cell activity." [GO:0016517]
xref_analog: GO:0005143
xref_analog: GO:0016517
xref_analog: PubMed:12805384
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors
relationship: part_of IEV:0000138 ! IL12 signaling pathway (JAK2, TYK2, STAT4)

[Term]
id: IEV:0001348
name: Binding of IL-10 and IL-10 receptor and conformational change of receptors
def: "Combining with interleukin-10 to initiate a change in cell activity." [GO:0004920]
xref_analog: GO:0004920
xref_analog: GO:0005141
xref_analog: PubMed:12626585
is_a: IEV:0000045 ! Binding of cytokine and cytokine receptors and conformational change of receptors
relationship: part_of IEV:0000139 ! IL10 signaling (JAK1, TYK2, STAT3)

[Term]
id: IEV:0001349
name: Phosphorylation of EGFR by PKC
def: "PKC then phosphorylates\n and regulates the activity of many proteins,\n including EGFR; phosphorylation of a\n threonine residue (Thr654) in the juxtamembrane domain modulates EGF binding affinity\n and kinase activity of the EGFR" [PubMed:15567847]
xref_analog: PubMed:15567847
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001351 ! Negative regulation of EGF signaling pathway

[Term]
id: IEV:0001350
name: Regulation of EGF signaling pathway
def: "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GO:0042058]
related_synonym: "regulation of EGF receptor signaling pathway" [GO:0042058]
related_synonym: "regulation of EGFR signaling pathway" [GO:0042058]
related_synonym: "regulation of epidermal growth factor receptor signaling pathway" [GO:0042058]
xref_analog: GO:0042058
is_a: IEV:0000834 ! Regulation of RTK signaling pathway
relationship: part_of IEV:0000865 ! EGF signaling pathway

[Term]
id: IEV:0001351
name: Negative regulation of EGF signaling pathway
def: "Any process that stops, prevents or reduces the rate, frequency or extent of epidermal growth factor receptor signaling pathway activity." [GO:0042059]
xref_analog: GO:0042059
is_a: IEV:0000835 ! Negative regulation of RTK signaling pathway
is_a: IEV:0001350 ! Regulation of EGF signaling pathway

[Term]
id: IEV:0001352
name: Positive regulation of EGF signaling pathway
def: "Any process that activates or increases the rate, frequency or extent of epidermal growth factor receptor signaling pathway activity." [GO:0045742]
xref_analog: GO:0045742
is_a: IEV:0000836 ! Positive regulation of RTK signaling pathway
is_a: IEV:0001350 ! Regulation of EGF signaling pathway

[Term]
id: IEV:0001353
name: Tyrosine biosynthesis
def: "The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.\n" [GO:0006571]
related_synonym: "tyrosine anabolism" []
related_synonym: "tyrosine biosynthetic process" []
related_synonym: "tyrosine formation" []
related_synonym: "tyrosine synthesis" []
xref_analog: GO:0006571
xref_analog: KEGG:map00400
is_a: IEV:0001460 ! Tyrosine metabolism

[Term]
id: IEV:0001354
name: Activation of c-Raf1 by PKC beta
def: "cPKCs (a and b1) have the potential to activate c-Raf1 in vivo while at the same time blocking further activation by growth factors and other PKC isotypes." [PubMed:9447975]
xref_analog: PubMed:9447975
is_a: IEV:0002485 ! Activation of Raf-1 by PKC

[Term]
id: IEV:0001355
name: Activation of Raf1 by Ras-GTP along with PKC alpha
xref_analog: PubMed:12417593
is_a: IEV:0001362 ! Activation of Raf by PKC

[Term]
id: IEV:0001356
name: Raf activation signaling (through RKIP)
def: "Protein kinase C (PKC) regulates activation of the Raf-1 signaling cascade by growth factors, but the mechanism by which this occurs has not been elucidated. Here we report that one mechanism involves dissociation of Raf kinase inhibitory protein (RKIP) from Raf-1. Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153)." [PubMed:12551925]
xref_analog: PubMed:12551925
is_a: IEV:0001364 ! Raf activation signaling (through PKC)

[Term]
id: IEV:0001357
name: Phosphorylation of RKIP by PKC
def: "Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153)." [PubMed:12551925]
xref_analog: PubMed:12551925
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001356 ! Raf activation signaling (through RKIP)

[Term]
id: IEV:0001358
name: Dissociation of RKIP and Raf1
def: "Protein kinase C (PKC) regulates activation of the Raf-1 signaling cascade by growth factors, but the mechanism by which this occurs has not been elucidated. Here we report that one mechanism involves dissociation of Raf kinase inhibitory protein (RKIP) from Raf-1." [PubMed:12551925]
xref_analog: PubMed:12551925
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0001356 ! Raf activation signaling (through RKIP)

[Term]
id: IEV:0001359
name: Phosphorylation of RKIP by cPKC
def: "Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153)." [PubMed:12551925, PubMed:<new dbxref>]
xref_analog: PubMed:12551925
is_a: IEV:0001357 ! Phosphorylation of RKIP by PKC

[Term]
id: IEV:0001360
name: Phosphorylation of RKIP by aPKC
def: "Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153)." [PubMed:12551925]
xref_analog: PubMed:12551925
is_a: IEV:0001357 ! Phosphorylation of RKIP by PKC

[Term]
id: IEV:0001361
name: Activation of c-Raf1 by PKC alpha
def: "cPKCs (a and b1) have the potential to activate c-Raf1 in vivo while at the same time blocking further activation by growth factors and other PKC isotypes." [PubMed:9447975]
xref_analog: PubMed:9447975
is_a: IEV:0002485 ! Activation of Raf-1 by PKC

[Term]
id: IEV:0001362
name: Activation of Raf by PKC
is_a: IEV:0000020 ! Activation in cytosol
relationship: part_of IEV:0001364 ! Raf activation signaling (through PKC)

[Term]
id: IEV:0001363
name: Activation of c-Raf1 by PKC eta
def: "At the level of Raf, the kinase that phosphorylates MEK-1, the activation cascade diverges; while conventional and novel PKCs (isotypes a and h) are potent activators of c-Raf1, atypical PKC-z cannot increase c-Raf1 activity,stimulating MEK by an independent mechanism." [PubMed:9447975]
xref_analog: PubMed:9447975
is_a: IEV:0002485 ! Activation of Raf-1 by PKC

[Term]
id: IEV:0001364
name: Raf activation signaling (through PKC)
is_a: IEV:0002072 ! Raf activation signaling

[Term]
id: IEV:0001365
name: Binding of PLC gamma1 and PIP3
xref_analog: PubMed:15343367
is_a: IEV:0000469 ! Binding of PLC gamma and PIP3

[Term]
id: IEV:0001366
name: Hydrolysis of PIP2 by PLC gamma1 to generate DAG and IP3
xref_analog: PubMed:15343367
is_a: IEV:0000268 ! Hydrolysis of PIP2 by PLC gamma to generate DAG and IP3
relationship: part_of IEV:0000866 ! NGF signaling pathway

[Term]
id: IEV:0001367
name: Binding of LAT_p and PLC gamma1
xref_analog: PubMed:12040176
xref_analog: PubMed:15343367
is_a: IEV:0000267 ! Binding of LAT_p and PLC gamma

[Term]
id: IEV:0001368
name: Phosphorylation of Vav by ZAP-70
xref_analog: PubMed:15343367
is_a: IEV:0000264 ! Phosphorylation of Vav by non-receptor tyrosine kinase

[Term]
id: IEV:0001369
name: Binding of SLP-76 and Vav
xref_analog: PubMed:12040176
xref_analog: PubMed:15343367
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0001370
name: Binding of SLP-76 and Nck
xref_analog: PubMed:12040176
xref_analog: PubMed:15343367
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0001371
name: Binding of Nck and PAK
xref_analog: PubMed:12040176
xref_analog: PubMed:15343367
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0001372
name: Activation of IKK beta by PKC theta
def: "T-cell lines expressing constitutively active PKC-theta, but not other constitutively active PKCs (alpha, delta, epsilon or zeta), were capable of activating an NF-kB reporter. Co-transfection experiments indicated that constitutively active PKC-theta upregulates the activity of IKKbeta, but not IKKalpha. Although a biochemical association between PKC-theta and IKKbeta could not be detected, the data suggest that PKC-theta directly or indirectly modulates IKKbeta kinase activity, thus regulating NF-kB." [PubMed:10733597]
xref_analog: PubMed:10733597
is_a: IEV:0000291 ! Activation of IKK complex by PKC theta

[Term]
id: IEV:0001373
name: Phosphorylation of IKK complex by NIK
def: "TNRF signaling" [XX:<new dbxref>]
xref_analog: GO:0007250
is_a: IEV:0000250 ! Phosphorylation of IKK complex by MAPKKK

[Term]
id: IEV:0001374
name: Regulation of T cell receptor signaling pathway
def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GO:0050856]
xref_analog: GO:0050856
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000460 ! T cell receptor signaling pathway

[Term]
id: IEV:0001375
name: Negative regulation of T cell receptor signaling pathway
def: "Any process that stops, prevents or reduces the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GO:0050860]
xref_analog: GO:0050860
is_a: IEV:0001374 ! Regulation of T cell receptor signaling pathway

[Term]
id: IEV:0001376
name: Positive regulation of T cell receptor signaling pathway
def: "Any process that activates or increases the rate, frequency or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GO:0050862]
xref_analog: GO:0050862
is_a: IEV:0001374 ! Regulation of T cell receptor signaling pathway
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0001377
name: Transcription of IL-2 by NF-kappaB
xref_analog: PubMed:11973130
is_a: IEV:0000485 ! Transcription of IL-2

[Term]
id: IEV:0001378
name: Phosphorylation of IKK beta by TAK1
xref_analog: PubMed:15125833
is_a: IEV:0000784 ! Phosphorylation of IKK complex by TAK1
relationship: part_of IEV:0003444 ! IKK activation signaling (through PKC beta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001379
name: IKK activation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling

[Term]
id: IEV:0001380
name: Oligomerization of MALT1
xref_analog: PubMed:15125833
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001381
name: Oligomerization of TRAF6
xref_analog: PubMed:15125833
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001382
name: Binding of MALT1 and TRAF6
xref_analog: PubMed:15125833
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)
relationship: part_of IEV:0003444 ! IKK activation signaling (through PKC beta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001383
name: Binding of BCL10 and MALT1
xref_analog: PubMed:15125833
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001384
name: Activation of TAK1 by ubiquitinated TRAF6
xref_analog: PubMed:15125833
is_a: IEV:0000038 ! Activation in unidentified cellular location
is_a: IEV:0000282 ! Activation of TAK1
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001385
name: Recruitment of CARMA1 and BCL10 to the lipid raft of the synapse by PKC theta
xref_analog: PubMed:15125833
is_a: IEV:0001386 ! Recruitment to the raft
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001386
name: Recruitment to the raft
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0001387
name: IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)
is_a: IEV:0001379 ! IKK activation signaling
relationship: part_of IEV:0000066 ! CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)

[Term]
id: IEV:0001388
name: Ubiquitination of TRAF6 by TRAF6
xref_analog: PubMed:15125833
is_a: IEV:0000202 ! Ubiquitination of TRAF6
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)
relationship: part_of IEV:0003444 ! IKK activation signaling (through PKC beta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001389
name: Ubiquitination of NEMO by TRAF6
xref_analog: PubMed:15125833
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)
relationship: part_of IEV:0003444 ! IKK activation signaling (through PKC beta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001390
name: Autophosphorylation of TAK1
xref_analog: PubMed:15125833
is_a: IEV:0000481 ! Autophosphorylation in cytosol
is_a: IEV:0000490 ! Autophosphorylation
relationship: part_of IEV:0001387 ! IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1)

[Term]
id: IEV:0001391
name: PKC theta activation signaling
xref_analog: PubMed:15343367
is_a: IEV:0000779 ! PKC activation signaling
relationship: part_of IEV:0000281 ! CD4 T cell receptor signaling (through Vav, Rac and JNK cascade)

[Term]
id: IEV:0001392
name: cPKC activation signaling
is_a: IEV:0000779 ! PKC activation signaling

[Term]
id: IEV:0001393
name: Binding of calcium ion and cPKC and active conformational change of cPKC
xref_analog: PubMed:10506570
xref_analog: PubMed:7499357
is_a: IEV:0000483 ! Binding of calcium ion and PKC and active conformational change of PKC
relationship: part_of IEV:0001392 ! cPKC activation signaling

[Term]
id: IEV:0001394
name: Binding of DAG and cPKC and active conformational change of cPKC
xref_analog: PubMed:7499357
is_a: IEV:0000270 ! Binding of DAG and PKC and active conformational change of PKC
relationship: part_of IEV:0001392 ! cPKC activation signaling

[Term]
id: IEV:0001395
name: Binding of DAG, calcium ion and cPKC and active conformational change of cPKC
xref_analog: PubMed:7499357
is_a: IEV:0000484 ! Binding of DAG, calcium ion and PKC and active conformational change of PKC

[Term]
id: IEV:0001396
name: Activation of MEKK3 by RIP1
is_a: IEV:0000257 ! Activation of MEKK3 by RIP

[Term]
id: IEV:0001397
name: Fas signaling pathway
xref_analog: KEGG:hsa04210
xref_analog: KEGG:mmu04210
xref_analog: KEGG:rno04210
is_a: IEV:0000465 ! TNFR signaling pathway

[Term]
id: IEV:0001398
name: Nuclear export of mRNA (smad7)
is_a: IEV:0000900 ! Nuclear export of mRNA (smad6/7)
relationship: part_of IEV:0000906 ! Gene expression of smad7 by R-smad:smad4

[Term]
id: IEV:0001399
name: Binding of smad7 and TGF beta receptor I
is_a: IEV:0000887 ! Binding of smad6/7 and TGF beta receptor I

[Term]
id: IEV:0001400
name: Regulation of Toll-like receptor pathway
def: "Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GO:0008592]
xref_analog: GO:0008592
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000462 ! Toll-like receptor signaling pathway

[Term]
id: IEV:0001401
name: Regulation of Ras mediated signaling
def: "Any process that modulates the frequency, rate or extent of Ras protein signal transduction." [GO:0046578]
related_synonym: "regulation of Ras protein signal transduction" [GO:0046578]
xref_analog: GO:0046578
is_a: IEV:0000681 ! Regulation of small GTPase mediated signaling
relationship: part_of IEV:0001258 ! Ras mediated signaling

[Term]
id: IEV:0001402
name: Positive regulation of Ras mediated signaling
def: "Any process that activates or increases the rate, frequency or extent of Ras protein signal transduction." [GO:0046579]
related_synonym: "positive regulation of Ras protein signal transduction" [GO:0046579]
xref_analog: GO:0046579
is_a: IEV:0000682 ! Positive regulation of small GTPase mediated signaling
is_a: IEV:0001401 ! Regulation of Ras mediated signaling

[Term]
id: IEV:0001403
name: Regulation of cell cycle regulation
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000366 ! Cell cycle regulation pathway

[Term]
id: IEV:0001404
name: Negative regulation of cell cycle regulation
is_a: IEV:0001403 ! Regulation of cell cycle regulation
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0001405
name: Positive regulation of cell cycle regulation
is_a: IEV:0001403 ! Regulation of cell cycle regulation
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0001406
name: Regulation of PDGF signaling pathway
is_a: IEV:0000834 ! Regulation of RTK signaling pathway
relationship: part_of IEV:0001257 ! PDGF signaling pathway

[Term]
id: IEV:0001407
name: Regulation of PLC signaling
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000471 ! PLC signaling

[Term]
id: IEV:0001408
name: Negative regulation of PLC signaling
is_a: IEV:0001407 ! Regulation of PLC signaling
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0001409
name: Positive regulation of PLC signaling
is_a: IEV:0001407 ! Regulation of PLC signaling
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0001410
name: Alanine and aspartate metabolism
def: "Alanine metabolism: The chemical reactions and pathways involving alanine, 2-aminopropanoic acid.\n\nAspartate metabolism: The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GO:0006522, GO:0006531]
xref_analog: GO:0006522
xref_analog: GO:0006531
xref_analog: KEGG:map00252
relationship: part_of IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001411
name: Glutamate metabolism
def: "The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GO:0006536]
related_synonym: "glutamate metabolic process" []
related_synonym: "glutamic acid metabolic process" []
related_synonym: "glutamic acid metabolism" []
xref_analog: GO:0006536
xref_analog: KEGG:map00251
relationship: part_of IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001412
name: Glycine, serine and threonine metabolism
def: "Glycine metabolism: The chemical reactions and pathways involving glycine, aminoethanoic acid.\n\nSerine metabolism: The chemical reactions and pathways involving L-serine, the levorotatory isomer of 2-amino-3-hydroxypropanoic acid.\n\nThreonine metabolism: The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GO:0006544, GO:0006563, GO:0006566]
xref_analog: GO:0006544
xref_analog: GO:0006563
xref_analog: GO:0006566
xref_analog: KEGG:map00260
relationship: part_of IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001413
name: Glycolysis and Gluconeogenesis
def: "Glycolysis: The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) in other compounds, including pyruvate.\n\nGluconeogenesis: The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. " [GO:0006094, GO:0006096]
xref_analog: GO:0006094
xref_analog: GO:0006096
xref_analog: KEGG:map00010
relationship: part_of IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001414
name: Pentose phosphate pathway
def: "The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [GO:0006098]
related_synonym: "hexose monophosphate pathway" []
related_synonym: "pentose phosphate shunt" []
related_synonym: "pentose-phosphate pathway" []
related_synonym: "pentose-phosphate shunt" []
xref_analog: GO:0006098
xref_analog: KEGG:map00030
relationship: part_of IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001415
name: Citrate cycle (TCA cycle)
def: "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two C02 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. " [GO:0006099]
related_synonym: "citric acid cycle" []
related_synonym: "Krebs cycle" []
related_synonym: "tricarboxylic acid cycle" []
xref_analog: GO:0006099
xref_analog: KEGG:map00020
relationship: part_of IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001416
name: Pentose and glucuronate interconversions
xref_analog: KEGG:map00040
relationship: part_of IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001417
name: Fructose and mannose metabolism
def: "Fructose metabolism: The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.\n\nMannose metabolism: The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GO:0006000, GO:0006013]
xref_analog: GO:0006000
xref_analog: GO:0006013
xref_analog: KEGG:map00051
relationship: part_of IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001418
name: Galactose metabolism
def: "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GO:0006012]
related_synonym: "galactose metabolic process" []
xref_analog: GO:0006012
xref_analog: KEGG:map00052
relationship: part_of IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001419
name: Ascorbate and aldarate metabolism
def: "Ascorbate metabolism: The chemical reactions and pathways involving L-ascorbic acid, a carbohydrate-like vitamin containing six carbon atoms per molecule. Widely distributed in fruit and vegetables." [GO:0019852]
xref_analog: GO:0019852
xref_analog: KEGG:map00053
relationship: part_of IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001420
name: Starch and sucrose metabolism
def: "Starch metabolism: The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose.\n\nSucrose metabolism: The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside. " [GO:0005982, GO:0005985]
xref_analog: GO:0005982
xref_analog: GO:0005985
xref_analog: KEGG:map00500
relationship: part_of IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001421
name: Aminosugars metabolism
def: "The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GO:0006040]
related_synonym: "amino sugar metabolic process" []
related_synonym: "amino sugar metabolism" []
related_synonym: "aminosaccharide metabolic process" []
related_synonym: "aminosaccharide metabolism" []
xref_analog: GO:0006040
xref_analog: KEGG:map00530
relationship: part_of IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001422
name: Carbohydrate Metabolism
def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GO:0005975]
related_synonym: "carbohydrate metabolic process" []
xref_analog: GO:0005975
xref_analog: KEGG:map01110
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001423
name: Nucleotide sugars metabolism
def: "The chemical reactions and pathways involving nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GO:0009225]
related_synonym: "nucleotide-sugar metabolic process" []
xref_analog: GO:0009225
xref_analog: KEGG:map00520
relationship: part_of IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001424
name: Pyruvate metabolism
def: "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GO:0006090]
related_synonym: "pyruvate metabolic process" []
xref_analog: GO:0006090
xref_analog: KEGG:map00620
relationship: part_of IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001425
name: Glyoxylate and dicarboxylate metabolism
def: "Glyoxylate metabolism: The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. \n\nDicarboxylate metabolism: The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [GO:0043648, GO:0046487]
xref_analog: GO:0043648
xref_analog: GO:0046487
xref_analog: KEGG:map00630
relationship: part_of IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001426
name: Propanoate metabolism
xref_analog: KEGG:map00640
relationship: part_of IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001427
name: Butanoate metabolism
xref_analog: KEGG:map00650
relationship: part_of IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001428
name: C5-Branched dibasic acid metabolism
xref_analog: KEGG:map00660
relationship: part_of IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001429
name: Inositol metabolism
def: "The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GO:0006020]
related_synonym: "inositol metabolic process" []
related_synonym: "vitamin Bh metabolic process" []
related_synonym: "vitamin Bh metabolism" []
xref_analog: GO:0006020
xref_analog: KEGG:map00031
relationship: part_of IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001430
name: Inositol phosphate metabolism
def: "The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GO:0043647]
related_synonym: "inositol phosphate metabolic process" []
xref_analog: GO:0043647
xref_analog: KEGG:map00562
relationship: part_of IEV:0001422 ! Carbohydrate Metabolism

[Term]
id: IEV:0001431
name: Oxidative phosphorylation
def: "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GO:0006119]
related_synonym: "respiratory-chain phosphorylation" []
xref_analog: GO:0006119
xref_analog: KEGG:map00190
relationship: part_of IEV:0001552 ! Energy Metabolism

[Term]
id: IEV:0001432
name: ATP synthesis
def: "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GO:0006754]
related_synonym: "ATP anabolism" []
related_synonym: "ATP biosynthesis" []
related_synonym: "ATP biosynthetic process" []
related_synonym: "ATP formation" []
xref_analog: GO:0006754
xref_analog: KEGG:map00193
relationship: part_of IEV:0001552 ! Energy Metabolism

[Term]
id: IEV:0001433
name: Photosynthesis
def: "The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [GO:0015979]
xref_analog: GO:0015979
xref_analog: KEGG:map00195
relationship: part_of IEV:0001552 ! Energy Metabolism

[Term]
id: IEV:0001434
name: Carbon fixation
xref_analog: KEGG:map00710
relationship: part_of IEV:0001552 ! Energy Metabolism

[Term]
id: IEV:0001435
name: Reductive carboxylate cycle (CO2 fixation)
xref_analog: KEGG:map00720
relationship: part_of IEV:0001552 ! Energy Metabolism

[Term]
id: IEV:0001436
name: Methane metabolism
def: "The chemical reactions and pathways involving methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GO:0015947]
related_synonym: "methane metabolic process" []
xref_analog: GO:0015947
xref_analog: KEGG:map00680
relationship: part_of IEV:0001552 ! Energy Metabolism

[Term]
id: IEV:0001437
name: Nitrogen metabolism
xref_analog: KEGG:map00910
relationship: part_of IEV:0001552 ! Energy Metabolism

[Term]
id: IEV:0001438
name: Sulfur metabolism
def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GO:0006790]
related_synonym: "sulfur metabolic process" []
related_synonym: "sulphur metabolic process" []
related_synonym: "sulphur metabolism" []
xref_analog: GO:0006790
xref_analog: KEGG:map00920
relationship: part_of IEV:0001552 ! Energy Metabolism

[Term]
id: IEV:0001439
name: Fatty acid biosynthesis
def: "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GO:0006633]
related_synonym: "fatty acid anabolism" []
related_synonym: "fatty acid biosynthetic process" []
related_synonym: "fatty acid formation" []
related_synonym: "fatty acid synthesis" []
xref_analog: GO:0006633
xref_analog: KEGG:map00061
is_a: IEV:0001441 ! Fatty acid metabolism

[Term]
id: IEV:0001440
name: Fatty acid elongation in mitochondria
def: "Fatty acid elongation: The elongation of a fatty acid chain by the sequential addition of two-carbon units." [GO:0030497]
xref_analog: GO:0030497
xref_analog: KEGG:map00062
is_a: IEV:0001439 ! Fatty acid biosynthesis

[Term]
id: IEV:0001441
name: Fatty acid metabolism
def: "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GO:0006633]
related_synonym: "fatty acid anabolism" []
related_synonym: "fatty acid biosynthetic process" []
related_synonym: "fatty acid formation" []
related_synonym: "fatty acid synthesis" []
xref_analog: GO:0006633
xref_analog: KEGG:map00071
relationship: part_of IEV:0001553 ! Lipid Metabolism

[Term]
id: IEV:0001442
name: Ketone bodies metabolism
def: "The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism." [GO:0046950]
related_synonym: "ketone body metabolic process" []
xref_analog: GO:0046950
xref_analog: KEGG:map00072
relationship: part_of IEV:0001553 ! Lipid Metabolism

[Term]
id: IEV:0001443
name: Biosynthesis of steroids
def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GO:0006694]
related_synonym: "steroid anabolism" []
related_synonym: "steroid biosynthetic process" []
related_synonym: "steroid formation" []
related_synonym: "steroid synthesis" []
related_synonym: "steroidogenesis" []
xref_analog: GO:0006694
xref_analog: KEGG:map00100
relationship: part_of IEV:0001553 ! Lipid Metabolism

[Term]
id: IEV:0001444
name: Bile acid biosynthesis
def: "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GO:0006699]
related_synonym: "bile acid anabolism" []
related_synonym: "bile acid biosynthetic process" []
related_synonym: "bile acid formation" []
related_synonym: "bile acid synthesis" []
xref_analog: GO:0006699
xref_analog: KEGG:map00120
relationship: part_of IEV:0001553 ! Lipid Metabolism

[Term]
id: IEV:0001445
name: C21-Steroid hormone metabolism
def: "The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GO:0008207]
related_synonym: "C21-steroid hormone metabolic process" []
xref_analog: GO:0008207
xref_analog: KEGG:map00140
relationship: part_of IEV:0001553 ! Lipid Metabolism

[Term]
id: IEV:0001446
name: Androgen and estrogen metabolism
def: "Androgen metabolism: The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.\n\nEstrogen metabolism: The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [GO:0008209, GO:0008210]
xref_analog: GO:0008209
xref_analog: GO:0008210
xref_analog: KEGG:map00150
relationship: part_of IEV:0001553 ! Lipid Metabolism

[Term]
id: IEV:0001447
name: Glycerolipid metabolism
def: "The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis." [GO:0046486]
related_synonym: "glycerolipid metabolic process" []
xref_analog: GO:0046486
xref_analog: KEGG:map00561
relationship: part_of IEV:0001553 ! Lipid Metabolism

[Term]
id: IEV:0001448
name: Glycerophospholipid metabolism
def: "The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [GO:0006650]
related_synonym: "glycerophospholipid metabolic process" []
related_synonym: "phosphoglyceride metabolic process" []
related_synonym: "phosphoglyceride metabolism" []
xref_analog: GO:0006650
xref_analog: KEGG:map00564
relationship: part_of IEV:0001553 ! Lipid Metabolism

[Term]
id: IEV:0001449
name: Prostaglandin and leukotriene metabolism
def: "Prostaglandin metabolism: The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.\n\nLeukotriene metabolism: The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GO:0006691, GO:0006693]
xref_analog: GO:0006691
xref_analog: GO:0006693
xref_analog: KEGG:mim00590
is_a: IEV:0001441 ! Fatty acid metabolism

[Term]
id: IEV:0001450
name: Purine metabolism
def: "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GO:0006163]
related_synonym: "purine nucleotide metabolism" []
xref_analog: GO:0006163
xref_analog: KEGG:map00230
relationship: part_of IEV:0001554 ! Nucleotide Metabolism

[Term]
id: IEV:0001451
name: Pyrimidine metabolism
def: "The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GO:0006220]
related_synonym: "pyrimidine nucleotide metabolism" []
xref_analog: GO:0006220
xref_analog: KEGG:map00240
relationship: part_of IEV:0001554 ! Nucleotide Metabolism

[Term]
id: IEV:0001454
name: Valine, leucine and isoleucine degradation
def: "Valine degradation: The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid. \n\nLeucine degradation: The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid.\n\nIsoleucine degradation: The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GO:0006550, GO:0006552, GO:0006574]
xref_analog: GO:0006550
xref_analog: GO:0006552
xref_analog: GO:0006574
xref_analog: KEGG:map00280
relationship: part_of IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001455
name: Valine, leucine and isoleucine biosynthesis
def: "Valine biosynthesis: The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid. \n\nLeucine biosynthesis: The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. \n\nIsoleucine biosynthesis: The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GO:0009097, GO:0009098, GO:0009099]
xref_analog: GO:0009097
xref_analog: GO:0009098
xref_analog: GO:0009099
xref_analog: KEGG:map00290
relationship: part_of IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001456
name: Lysine biosynthesis
def: "The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid. " [GO:0009085]
related_synonym: "lysine anabolism" []
related_synonym: "lysine biosynthetic process" []
related_synonym: "lysine formation" []
related_synonym: "lysine synthesis" []
xref_analog: GO:0009085
xref_analog: KEGG:map00300
relationship: part_of IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001457
name: Lysine degradation
def: "The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid. " [GO:0006554]
related_synonym: "lysine breakdown" []
related_synonym: "lysine catabolic process" []
related_synonym: "lysine catabolism" []
xref_analog: GO:0006554
xref_analog: KEGG:map00310
relationship: part_of IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001458
name: Arginine and proline metabolism
def: "Arginine metabolism: The chemical reactions and pathways involving arginine, 2-amino-5-guanidinopentanoic acid.\n\nProline metabolism: The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GO:0006525, GO:0006560]
xref_analog: GO:0006525
xref_analog: GO:0006560
xref_analog: KEGG:map00330
relationship: part_of IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001459
name: Histidine metabolism
def: "The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. " [GO:006547]
related_synonym: "histidine metabolic process" []
xref_analog: GO:006547
xref_analog: KEGG:map00340
relationship: part_of IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001460
name: Tyrosine metabolism
def: "The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GO:0006570]
related_synonym: "tyrosine metabolic process" []
xref_analog: GO:0006570
xref_analog: KEGG:map00350
relationship: part_of IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001461
name: Phenylalanine metabolism
def: "L-phenylalanine metabolism: The chemical reactions and pathways involving L-phenylalanine, the levorotatory isomer of 2-amino-3-phenylpropanoic acid." [GO:0006558]
xref_analog: GO:0006558
xref_analog: KEGG:map00360
relationship: part_of IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001462
name: Tryptophan metabolism
def: "The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [GO:0006568]
related_synonym: "tryptophan metabolic process" []
xref_analog: GO:0006568
xref_analog: KEGG:map00380
relationship: part_of IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001463
name: Phenylalanine biosynthesis
alt_id: IEV:0000410
def: "L-phenylalanine biosynthesis: The chemical reactions and pathways resulting in the formation of L-phenylalanine, the levorotatory isomer of 2-amino-3-phenylpropanoic acid." [GO:0009094]
related_synonym: "Phenylalanine biosynthesis pathway" []
xref_analog: GO:0009094
xref_analog: KEGG:map00400
is_a: IEV:0001461 ! Phenylalanine metabolism
relationship: part_of IEV:0000396 ! Lignin biosynthesis
relationship: part_of IEV:0000441 ! Lignin biosynthesis (angiosperm)
relationship: part_of IEV:0000442 ! Lignin biosynthesis (gymnosperm)
relationship: part_of IEV:0000443 ! Lignin biosynthesis (grasses)

[Term]
id: IEV:0001464
name: Urea cycle and metabolism of amino groups
def: "Urea cycle: A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea.\n\nUrea cycle intermediate metabolism: The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [GO:0000050, GO:0000051]
xref_analog: GO:0000050
xref_analog: GO:0000051
xref_analog: KEGG:map00220
relationship: part_of IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001465
name: beta-Alanine metabolism
def: "The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GO:0019482]
related_synonym: "beta-alanine metabolic process" []
xref_analog: GO:0019482
xref_analog: KEGG:map00410
relationship: part_of IEV:0001557 ! Metabolism of Other Amino Acids

[Term]
id: IEV:0001466
name: Methionine and Cysteine metabolism
alt_id: IEV:0001452
alt_id: IEV:0001453
def: "Methionine metabolism: The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.\n\nCysteine metabolism: The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid." [GO:0006534, GO:0006555]
xref_analog: GO:0006534
xref_analog: GO:0006555
xref_analog: KEGG:map00271
xref_analog: KEGG:map00272
xref_analog: KEGG:map00430
relationship: part_of IEV:0001556 ! Amino Acid Metabolism

[Term]
id: IEV:0001467
name: Aminophosphonate metabolism
xref_analog: KEGG:map00440
relationship: part_of IEV:0001557 ! Metabolism of Other Amino Acids

[Term]
id: IEV:0001468
name: Selenoamino acid metabolism
xref_analog: KEGG:map00450
relationship: part_of IEV:0001557 ! Metabolism of Other Amino Acids

[Term]
id: IEV:0001469
name: Cyanoamino acid metabolism
xref_analog: KEGG:map00460
relationship: part_of IEV:0001557 ! Metabolism of Other Amino Acids

[Term]
id: IEV:0001470
name: D-Glutamine and D-glutamate metabolism
xref_analog: KEGG:map00471
relationship: part_of IEV:0001557 ! Metabolism of Other Amino Acids

[Term]
id: IEV:0001471
name: D-Arginine and D-ornithine metabolism
xref_analog: KEGG:map00472
relationship: part_of IEV:0001557 ! Metabolism of Other Amino Acids

[Term]
id: IEV:0001472
name: D-Alanine metabolism
def: "The chemical reactions and pathways involving D-alanine, the dextrorotatory isomer of the amino acid alanine." [GO:0046436]
related_synonym: "D-alanine metabolic process" []
xref_analog: GO:0046436
xref_analog: KEGG:map00473
relationship: part_of IEV:0001557 ! Metabolism of Other Amino Acids

[Term]
id: IEV:0001473
name: Glutathione metabolism
def: "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [GO:0006749]
related_synonym: "glutathione metabolic process" []
xref_analog: GO:0006749
xref_analog: KEGG:map00480
relationship: part_of IEV:0001557 ! Metabolism of Other Amino Acids

[Term]
id: IEV:0001474
name: N-Glycan biosynthesis
xref_analog: KEGG:map00510
relationship: part_of IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001475
name: High-mannose type N-glycan biosynthesis
xref_analog: KEGG:map00513
relationship: part_of IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001476
name: N-Glycan degradation
xref_analog: KEGG:map00511
relationship: part_of IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001477
name: O-Glycan biosynthesis
xref_analog: KEGG:map00512
relationship: part_of IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001478
name: Chondroitin sulfate biosynthesis
def: "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.\n\n" [GO:0030206]
related_synonym: "chondroitin sulfate anabolism" []
related_synonym: "chondroitin sulfate biosynthetic process" []
related_synonym: "chondroitin sulfate formation" []
related_synonym: "chondroitin sulfate synthesis" []
related_synonym: "chondroitin sulphate biosynthesis" []
xref_analog: GO:0030206
xref_analog: KEGG:map00532
relationship: part_of IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001479
name: CD28 signaling
related_synonym: "CD28 Costimulation" [PubMed:12121659]
xref_analog: PubMed:12121659
is_a: IEV:0000543 ! Positive regulation of CD4 T cell receptor signaling (through PLC gamma, PKC and IKK-NF-kappaB cascade)
is_a: IEV:0001842 ! Signal transduction pathway
is_a: IEV:0002201 ! Positive regulation of CD4 T cell receptor signaling (through Ras Vav, Rac and JNK cascade)

[Term]
id: IEV:0001480
name: Phosphorylation of CD28 by Src family
xref_analog: PubMed:12121659
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001479 ! CD28 signaling

[Term]
id: IEV:0001481
name: Phosphorylation of CD28 by Lck
xref_analog: PubMed:12121659
is_a: IEV:0001480 ! Phosphorylation of CD28 by Src family

[Term]
id: IEV:0001482
name: Phosphorylation of CD28 by Fyn
xref_analog: PubMed:12121659
is_a: IEV:0001480 ! Phosphorylation of CD28 by Src family

[Term]
id: IEV:0001483
name: Binding of CD28 and PI3K
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001479 ! CD28 signaling

[Term]
id: IEV:0001484
name: AKT(PKB) activation signaling
related_synonym: "PI3K-AKT signaling" [PubMed:10485710]
xref_analog: PubMed:10485710
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0000166 ! AKT(PKB)-Bad signaling
relationship: part_of IEV:0001479 ! CD28 signaling
relationship: part_of IEV:0001707 ! AKT(PKB)-caspase signaling
relationship: part_of IEV:0001709 ! AKT(PKB)-FKHRL1 signaling
relationship: part_of IEV:0001727 ! AKT(PKB)-IKK signaling
relationship: part_of IEV:0001745 ! AKT(PKB)-GSK3beta signaling

[Term]
id: IEV:0001485
name: Regulation of AKT(PKB) activation signaling
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0001484 ! AKT(PKB) activation signaling

[Term]
id: IEV:0001486
name: Negative regulation of AKT(PKB) activation signaling
is_a: IEV:0001485 ! Regulation of AKT(PKB) activation signaling
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0001487
name: Positive regulation of AKT(PKB) activation signaling
is_a: IEV:0001485 ! Regulation of AKT(PKB) activation signaling
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0001488
name: Dephosphorylation of PIP3 by PTEN
is_a: IEV:0000414 ! Dephosphorylation in plasma membrane
relationship: part_of IEV:0001858 ! Negative regulation of (phosphorylation of PIP2) in AKT(PKB) activation signaling

[Term]
id: IEV:0001489
name: Keratan sulfate biosynthesis
def: "The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GO:0018146]
related_synonym: "keratan sulfate anabolism" []
related_synonym: "keratan sulfate biosynthetic process" []
related_synonym: "keratan sulfate formation" []
related_synonym: "keratan sulfate synthesis" []
related_synonym: "keratan sulphate biosynthesis" []
related_synonym: "keratan sulphate biosynthetic process" []
xref_analog: GO:0018146
xref_analog: KEGG:map00533
relationship: part_of IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001490
name: Glycosaminoglycan degradation
def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. " [GO:0006027]
related_synonym: "glycosaminoglycan breakdown" []
related_synonym: "glycosaminoglycan catabolic process" []
related_synonym: "glycosaminoglycan catabolism" []
xref_analog: GO:0006027
xref_analog: KEGG:map00531
relationship: part_of IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001491
name: Lipopolysaccharide biosynthesis
def: "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GO:0009103]
related_synonym: "lipopolysaccharide anabolism" []
related_synonym: "lipopolysaccharide biosynthetic process" []
related_synonym: "lipopolysaccharide formation" []
related_synonym: "lipopolysaccharide synthesis" []
xref_analog: GO:0009103
xref_analog: KEGG:map00540
relationship: part_of IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001492
name: Peptidoglycan biosynthesis
def: "The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [GO:0009252]
related_synonym: "murein biosynthesis" []
related_synonym: "murein biosynthetic process" []
related_synonym: "peptidoglycan anabolism" []
related_synonym: "peptidoglycan biosynthetic process" []
related_synonym: "peptidoglycan formation" []
related_synonym: "peptidoglycan synthesis" []
xref_analog: GO:0009252
xref_analog: KEGG:map00550
relationship: part_of IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001493
name: Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
def: "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GO:0006506]
related_synonym: "glycosylphosphatidylinositol biosynthesis" []
related_synonym: "glycosylphosphatidylinositol biosynthetic process" []
related_synonym: "GPI anchor anabolism" []
related_synonym: "GPI anchor biosynthetic process" []
related_synonym: "GPI anchor formation" []
related_synonym: "GPI anchor synthesis" []
xref_analog: GO:0006506
xref_analog: KEGG:map00563
relationship: part_of IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001494
name: Sphingolipid metabolism
def: "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GO:0006665]
related_synonym: "sphingolipid metabolic process" []
xref_analog: GO:0006665
xref_analog: KEGG:map00600
relationship: part_of IEV:0001553 ! Lipid Metabolism

[Term]
id: IEV:0001495
name: Glycosphingolipid biosynthesis-lactoseries
xref_analog: KEGG:map00601
relationship: part_of IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001496
name: Glycosphingolipid biosynthesis-neo-lactoseries
xref_analog: KEGG:map00602
relationship: part_of IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001497
name: Glycosphingolipid biosynthesis-globoseries
def: "The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1,3)-Gal-alpha(1,4)Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes." [GO:0001575]
related_synonym: "globoside metabolic process" []
related_synonym: "globoside metabolism" []
xref_analog: GO:0001575
xref_analog: KEGG:map00603
relationship: part_of IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001498
name: Glycosphingolipid biosynthesis-ganglioseries
def: "The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [GO:0001574]
related_synonym: "ganglioside anabolism" []
related_synonym: "ganglioside biosynthesis" []
related_synonym: "ganglioside biosynthetic process" []
related_synonym: "ganglioside formation" []
related_synonym: "ganglioside synthesis" []
xref_analog: GO:0001574
xref_analog: KEGG:map00604
relationship: part_of IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001499
name: Biosynthesis of vancomycin group antibiotics
xref_analog: KEGG:map01055
relationship: part_of IEV:0001559 ! Biosynthesis of Polyketides and Nonribosomal Peptides

[Term]
id: IEV:0001500
name: Biosynthesis of 12-, 14- and 16-membered macrolides
xref_analog: KEGG:map00522
relationship: part_of IEV:0001559 ! Biosynthesis of Polyketides and Nonribosomal Peptides

[Term]
id: IEV:0001501
name: Biosynthesis of ansamycins
xref_analog: KEGG:map01051
relationship: part_of IEV:0001559 ! Biosynthesis of Polyketides and Nonribosomal Peptides

[Term]
id: IEV:0001502
name: Biosynthesis of type II polyketide backbone
xref_analog: KEGG:map01056
relationship: part_of IEV:0001559 ! Biosynthesis of Polyketides and Nonribosomal Peptides

[Term]
id: IEV:0001503
name: Biosynthesis of type II polyketide products
xref_analog: KEGG:map01057
relationship: part_of IEV:0001559 ! Biosynthesis of Polyketides and Nonribosomal Peptides

[Term]
id: IEV:0001504
name: Polyketide sugar unit biosynthesis
xref_analog: KEGG:map00523
relationship: part_of IEV:0001559 ! Biosynthesis of Polyketides and Nonribosomal Peptides

[Term]
id: IEV:0001505
name: Receptor internalization
def: "The process by which cell surface receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation; serves as a mechanism to downregulate receptor signaling." [GO:0031623]
xref_analog: GO:0031623
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0001506
name: Biosynthesis of siderophore group nonribosomal peptides
xref_analog: KEGG:map01053
relationship: part_of IEV:0001559 ! Biosynthesis of Polyketides and Nonribosomal Peptides

[Term]
id: IEV:0001507
name: Thiamine metabolism
def: "The chemical reactions and pathways involving thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GO:0006772]
related_synonym: "thiamin metabolic process" []
related_synonym: "thiamin metabolism" []
related_synonym: "thiamine metabolic process" []
related_synonym: "vitamin B1 metabolic process" []
related_synonym: "vitamin B1 metabolism" []
xref_analog: GO:0006772
xref_analog: KEGG:map00730
relationship: part_of IEV:0001555 ! Metabolism of Cofactors and Vitamins

[Term]
id: IEV:0001508
name: Riboflavin metabolism
def: "The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GO:0006771]
related_synonym: "riboflavin metabolic process" []
related_synonym: "vitamin B2 metabolic process" []
related_synonym: "vitamin B2 metabolism" []
related_synonym: "vitamin G metabolic process" []
related_synonym: "vitamin G metabolism" []
xref_analog: GO:0006771
xref_analog: KEGG:map00740
relationship: part_of IEV:0001555 ! Metabolism of Cofactors and Vitamins

[Term]
id: IEV:0001509
name: Vitamin B6 metabolism
def: "The chemical reactions and pathways involving any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GO:0042816]
related_synonym: "vitamin B6 metabolic process" []
xref_analog: GO:0042816
xref_analog: KEGG:map00750
relationship: part_of IEV:0001555 ! Metabolism of Cofactors and Vitamins

[Term]
id: IEV:0001510
name: Nicotinate and nicotinamide metabolism
def: "Nicotinamide metabolism: The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms." [GO:0006769]
xref_analog: GO:0006769
xref_analog: GO:0046497
xref_analog: KEGG:map00760
relationship: part_of IEV:0001555 ! Metabolism of Cofactors and Vitamins

[Term]
id: IEV:0001511
name: Pantothenate and CoA biosynthesis
def: "Pantothenate biosynthesis: The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. \n\nCoA biosynthesis: The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GO:0015937, GO:0015940]
xref_analog: GO:0015937
xref_analog: GO:0015940
xref_analog: KEGG:map00770
relationship: part_of IEV:0001555 ! Metabolism of Cofactors and Vitamins

[Term]
id: IEV:0001512
name: Biotin metabolism
def: "The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GO:0006768]
related_synonym: "biotin metabolic process" []
related_synonym: "vitamin B7 metabolic process" []
related_synonym: "vitamin B7 metabolism" []
related_synonym: "vitamin H metabolic process" []
related_synonym: "vitamin H metabolism" []
xref_analog: GO:0006768
xref_analog: KEGG:map00780
relationship: part_of IEV:0001555 ! Metabolism of Cofactors and Vitamins

[Term]
id: IEV:0001514
name: Folate metabolism
alt_id: IEV:0001513
def: "The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GO:0046655]
related_synonym: "folate metabolic process" []
related_synonym: "folic acid metabolic process" []
related_synonym: "folic acid metabolism" []
related_synonym: "vitamin B9 metabolic process" []
related_synonym: "vitamin B9 metabolism" []
related_synonym: "vitamin M metabolic process" []
related_synonym: "vitamin M metabolism" []
xref_analog: GO:0046655
xref_analog: KEGG:map00670
xref_analog: KEGG:map00790
relationship: part_of IEV:0001555 ! Metabolism of Cofactors and Vitamins

[Term]
id: IEV:0001515
name: Retinol metabolism
def: "The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GO:0042572]
related_synonym: "retinol metabolic process" []
related_synonym: "vitamin A1 alcohol metabolic process" []
related_synonym: "vitamin A1 alcohol metabolism" []
related_synonym: "vitamin A1 metabolic process" []
related_synonym: "vitamin A1 metabolism" []
xref_analog: GO:0042572
xref_analog: KEGG:map00830
relationship: part_of IEV:0001555 ! Metabolism of Cofactors and Vitamins

[Term]
id: IEV:0001516
name: Porphyrin and chlorophyll metabolism
def: "Porphyrin metabolism: The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.\n\nChlorophyll metabolism: The chemical reactions and pathways involving chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GO:0006778, GO:0015994]
xref_analog: GO:0006778
xref_analog: GO:0015994
xref_analog: KEGG:map00860
relationship: part_of IEV:0001555 ! Metabolism of Cofactors and Vitamins

[Term]
id: IEV:0001517
name: Ubiquinone biosynthesis
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GO:0006744]
related_synonym: "coenzyme Q biosynthesis" []
related_synonym: "coenzyme Q biosynthetic process" []
related_synonym: "ubiquinone anabolism" []
related_synonym: "ubiquinone biosynthetic process" []
related_synonym: "ubiquinone formation" []
related_synonym: "ubiquinone synthesis" []
xref_analog: GO:0006744
xref_analog: KEGG:map00130
relationship: part_of IEV:0001555 ! Metabolism of Cofactors and Vitamins

[Term]
id: IEV:0001518
name: Terpenoid biosynthesis
def: "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. " [GO:0016114]
related_synonym: "terpenoid anabolism" []
related_synonym: "terpenoid biosynthetic process" []
related_synonym: "terpenoid formation" []
related_synonym: "terpenoid synthesis" []
xref_analog: GO:0016114
xref_analog: KEGG:map00900
relationship: part_of IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001519
name: Monoterpenoid biosynthesis
def: "The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton." [GO:0016099]
related_synonym: "monoterpenoid anabolism" []
related_synonym: "monoterpenoid biosynthetic process" []
related_synonym: "monoterpenoid formation" []
related_synonym: "monoterpenoid synthesis" []
xref_analog: GO:0016099
xref_analog: KEGG:map00902
relationship: part_of IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001520
name: Limonene and pinene degradation
def: "Limonene degradation: The chemical reactions and pathways resulting in the breakdown of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene.\n\nalpha-pinene degradation: The chemical reactions and pathways resulting in the breakdown of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature." [GO:0046249, GO:0046251]
xref_analog: GO:0046249
xref_analog: GO:0046251
xref_analog: KEGG:map00903
relationship: part_of IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001521
name: Diterpenoid biosynthesis
def: "The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units." [GO:0016102]
related_synonym: "diterpenoid anabolism" []
related_synonym: "diterpenoid biosynthetic process" []
related_synonym: "diterpenoid formation" []
related_synonym: "diterpenoid synthesis" []
xref_analog: GO:0016102
xref_analog: KEGG:map00904
relationship: part_of IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001522
name: Indole and ipecac alkaloid biosynthesis
def: "Indole biosynthesis: The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [GO:0042432]
xref_analog: GO:0042432
xref_analog: KEGG:map00901
relationship: part_of IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001523
name: Stilbene, coumarine and lignin biosynthesis
def: "Stilbene biosynthesis: The chemical reactions and pathways resulting in the formation of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA.\n\nCoumarin biosynthesis: The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids.\n\nLignin biosynthesis: The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers." [GO:0009805, GO:0009809, GO:0009811]
xref_analog: GO:0009805
xref_analog: GO:0009809
xref_analog: GO:0009811
xref_analog: KEGG:map00940
relationship: part_of IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001524
name: Flavonoid biosynthesis
def: "The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GO:0009813]
related_synonym: "flavonoid anabolism" []
related_synonym: "flavonoid biosynthetic process" []
related_synonym: "flavonoid formation" []
related_synonym: "flavonoid synthesis" []
xref_analog: GO:0009813
xref_analog: KEGG:map00941
relationship: part_of IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001525
name: Alkaloid biosynthesis
alt_id: IEV:0001526
def: "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases)." [GO:0009821]
related_synonym: "alkaloid anabolism" []
related_synonym: "alkaloid biosynthetic process" []
related_synonym: "alkaloid formation" []
related_synonym: "alkaloid synthesis" []
xref_analog: GO:0009821
xref_analog: KEGG:map00950
xref_analog: KEGG:map00960
relationship: part_of IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001527
name: Penicillins and cephalosporins biosynthesis
def: "Penicillin biosynthesis: The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system.\n\nCephalosporin biosynthesis: The formation from simpler components of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [GO:0042318, GO:0043646]
xref_analog: GO:0042318
xref_analog: GO:0043646
xref_analog: KEGG:map00311
relationship: part_of IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001528
name: beta-Lactam resistanse
xref_analog: KEGG:map00312
relationship: part_of IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001529
name: Streptomycin biosynthesis
def: "The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GO:0019872]
related_synonym: "streptomycin anabolism" []
related_synonym: "streptomycin biosynthetic process" []
related_synonym: "streptomycin formation" []
related_synonym: "streptomycin synthesis" []
xref_analog: GO:0019872
xref_analog: KEGG:map00521
relationship: part_of IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001530
name: Tetracycline biosynthesis
def: "The formation from simpler components of tetracycline, a broad spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GO:0043644]
related_synonym: "tetracyclin biosynthesis" []
related_synonym: "tetracycline biosynthetic process" []
xref_analog: GO:0043644
xref_analog: KEGG:map00253
relationship: part_of IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001531
name: Clavulanic acid biosynthesis
xref_analog: KEGG:map00331
relationship: part_of IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001532
name: Puromycin biosynthesis
def: "The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [GO:0043638]
related_synonym: "puromycin biosynthetic process" []
xref_analog: GO:0043638
xref_analog: KEGG:map00231
relationship: part_of IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001533
name: Novobiocin biosynthesis
def: "The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [GO:0043642]
related_synonym: "novobiocin biosynthetic process" []
xref_analog: GO:0043642
xref_analog: KEGG:map00401
relationship: part_of IEV:0001560 ! Biosynthesis of Secondary Metabolites

[Term]
id: IEV:0001534
name: Caprolactam degradation
def: "The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid." [GO:0019384]
related_synonym: "caprolactam breakdown" []
related_synonym: "caprolactam catabolic process" []
related_synonym: "caprolactam catabolism" []
xref_analog: GO:0019384
xref_analog: KEGG:map00930
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001535
name: Biphenyl degradation
xref_analog: GO:0018879
xref_analog: KEGG:map00621
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001536
name: Toluene and xylene degradation
def: "Toluene degradation: The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products.\n\nXylene degradation: The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GO:0042184, GO:0042203]
xref_analog: GO:0042184
xref_analog: GO:0042203
xref_analog: KEGG:map00622
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001537
name: gamma-Hexachlorocyclohexane degradation
xref_analog: GO:0018919
xref_analog: KEGG:map00361
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001538
name: 3-Chloroacrylic acid degradation
xref_analog: GO:0018888
xref_analog: KEGG:map00641
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001539
name: 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane degradation
def: "The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GO:0042188]
related_synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane breakdown" []
related_synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process" []
related_synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolism" []
related_synonym: "DDT catabolic process" []
related_synonym: "DDT catabolism" []
xref_analog: GO:0042188
xref_analog: KEGG:map00351
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001540
name: 2,4-Dichlorobenzoate degradation
def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GO:0046298]
related_synonym: "2,4-dichlorobenzoate breakdown" []
related_synonym: "2,4-dichlorobenzoate catabolic process" []
related_synonym: "2,4-dichlorobenzoate catabolism" []
xref_analog: GO:0046298
xref_analog: KEGG:map00623
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001541
name: 1,2-Dichloroethane degradation
def: "The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GO:0019260]
related_synonym: "1,2-dichloroethane breakdown" []
related_synonym: "1,2-dichloroethane catabolic process" []
related_synonym: "1,2-dichloroethane catabolism" []
xref_analog: GO:0019260
xref_analog: KEGG:map00631
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001542
name: Tetrachloroethene degradation
def: "The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines." [GO:0019337]
related_synonym: "etrachloroethylene degradation" []
related_synonym: "tetrachloroethene catabolic process" []
related_synonym: "tetrachloroethene catabolism" []
related_synonym: "tetrachloroethylene breakdown" []
related_synonym: "tetrachloroethylene catabolic process" []
related_synonym: "tetrachloroethylene catabolism" []
xref_analog: GO:0019337
xref_analog: KEGG:map00625
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001543
name: Styrene degradation
def: "The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene." [GO:0042207]
related_synonym: "styrene breakdown" []
related_synonym: "styrene catabolic process" []
related_synonym: "styrene catabolism" []
xref_analog: GO:0042207
xref_analog: KEGG:map00643
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001544
name: 1,4-Dichlorobenzene degradation
def: "The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. " [GO:0019261]
related_synonym: "1,4-dichlorobenzene breakdown" []
related_synonym: "1,4-dichlorobenzene catabolic process" []
related_synonym: "1,4-dichlorobenzene catabolism" []
xref_analog: GO:0019261
xref_analog: KEGG:map00627
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001545
name: Nitrobenzene degradation
xref_analog: GO:0018916
xref_analog: KEGG:map00626
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001546
name: Ethylbenzene degradation
def: "The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen." [GO:0010130]
xref_analog: GO:0010130
xref_analog: KEGG:map00642
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001547
name: Fluorene degradation
def: "The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [GO:0019429]
related_synonym: "fluorene breakdown" []
related_synonym: "fluorene catabolic process" []
related_synonym: "fluorene catabolism" []
xref_analog: GO:0019429
xref_analog: KEGG:map00628
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001548
name: Carbazole degradation
def: "The chemical reactions and pathways resulting in the breakdown of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GO:0046232]
related_synonym: "carbazole breakdown" []
related_synonym: "carbazole catabolic process" []
related_synonym: "carbazole catabolism" []
xref_analog: GO:0046232
xref_analog: KEGG:map00629
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001549
name: Benzoate degradation via CoA ligation
def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway." [GO:0010128]
related_synonym: "anaerobic benzoate breakdown" []
related_synonym: "anaerobic benzoate catabolic process" []
related_synonym: "anaerobic benzoate catabolism" []
related_synonym: "anaerobic benzoate degradation" []
related_synonym: "benzoate catabolic process via CoA ligation" []
xref_analog: GO:0010128
xref_analog: KEGG:map00632
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001550
name: Benzoate degradation via hydroxylation
def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol." [GO:0043640]
related_synonym: "benzoate breakdown via hydroxylation" []
related_synonym: "benzoate catabolic process via hydroxylation" []
xref_analog: GO:0043640
xref_analog: KEGG:map00362
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001551
name: Atrazine degradation
def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide." [GO:0019381]
related_synonym: "atrazine breakdown" []
related_synonym: "atrazine catabolic process" []
related_synonym: "atrazine catabolism" []
xref_analog: GO:0019381
xref_analog: KEGG:map00791
relationship: part_of IEV:0001561 ! Xenobiotics Biodegradation and Metabolism

[Term]
id: IEV:0001552
name: Energy Metabolism
xref_analog: KEGG:map01120
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001553
name: Lipid Metabolism
def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GO:0006629]
related_synonym: "lipid metabolic process" []
xref_analog: GO:0006629
xref_analog: KEGG:map01130
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001554
name: Nucleotide Metabolism
def: "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GO:0009117]
related_synonym: "nucleotide metabolic process" []
xref_analog: GO:0009117
xref_analog: KEGG:map01140
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001555
name: Metabolism of Cofactors and Vitamins
def: "Cofactor metabolism: The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.\n\nVitamin metabolism: The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GO:0006766, GO:0051186]
xref_analog: GO:0006766
xref_analog: GO:0051186
xref_analog: KEGG:map01190
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001556
name: Amino Acid Metabolism
def: "The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents." [GO:0006520]
related_synonym: "amino acid metabolic process" []
xref_analog: GO:0006520
xref_analog: KEGG:map01150
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001557
name: Metabolism of Other Amino Acids
xref_analog: KEGG:map0160
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001558
name: Glycan Biosynthesis and Metabolism
def: "Glycan biosynthesis: The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages.\n\nGlycan metabolism: The chemical reactions and pathways involving polysaccharides, a polymer of more than 10 monosaccharide residues joined by glycosidic linkages." [GO:0000271, GO:0005976]
xref_analog: GO:0000271
xref_analog: GO:0005976
xref_analog: KEGG:map01170
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001559
name: Biosynthesis of Polyketides and Nonribosomal Peptides
def: "Polyketide biosynthesis: The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty-acid biosynthesis but without the intermediate reductive steps.\n\nNonribosomal peptide biosynthesis: The process whereby peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione." [GO:0019184, GO:0030639]
xref_analog: GO:0019184
xref_analog: GO:0030639
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001560
name: Biosynthesis of Secondary Metabolites
xref_analog: KEGG:map01195
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001561
name: Xenobiotics Biodegradation and Metabolism
def: "Xenobiotic degradation: The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.\n\nXenobiotic metabolism: The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.\n\n" [GO:0006805, GO:0042178]
xref_analog: GO:0006805
xref_analog: GO:0042178
xref_analog: KEGG:map01196
is_a: IEV:0000818 ! Metabolic pathway

[Term]
id: IEV:0001562
name: Osmotic pressure treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0001563
name: Humidity treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0001564
name: High osmotic pressure treatment
is_a: IEV:0001562 ! Osmotic pressure treatment

[Term]
id: IEV:0001565
name: Heat shock treatment
is_a: IEV:0000379 ! Heat treatment

[Term]
id: IEV:0001566
name: Anticancer drug medication
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0001567
name: Protein synthesis inhibitor medication
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0001568
name: Ultraviolet irradiation
is_a: IEV:0000373 ! Wavelength of light treatment

[Term]
id: IEV:0001569
name: Cyclohexemide medication
is_a: IEV:0001567 ! Protein synthesis inhibitor medication

[Term]
id: IEV:0001570
name: Proteasome inhibitor medication
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0001571
name: Transcription inhibitor medication
is_a: IEV:0000292 ! Medication

[Term]
id: IEV:0001572
name: DRB medication
is_a: IEV:0001571 ! Transcription inhibitor medication

[Term]
id: IEV:0001573
name: Hydrogen peroxide treatment
is_a: IEV:0000043 ! Inorganic chemical treatment

[Term]
id: IEV:0001574
name: Abscisic acid stimulus
is_a: IEV:0000294 ! Plant hormone medication

[Term]
id: IEV:0001575
name: Auxin stimulus
is_a: IEV:0000294 ! Plant hormone medication

[Term]
id: IEV:0001576
name: Sorbitol treatment
is_a: IEV:0000064 ! Organic chemical treatment
is_a: IEV:0001564 ! High osmotic pressure treatment

[Term]
id: IEV:0001577
name: Brassinosteroid stimulus
is_a: IEV:0000294 ! Plant hormone medication

[Term]
id: IEV:0001578
name: Cytokinin stimulus
is_a: IEV:0000294 ! Plant hormone medication

[Term]
id: IEV:0001579
name: Ethylene stimulus
is_a: IEV:0000294 ! Plant hormone medication

[Term]
id: IEV:0001580
name: Gibberellic acid stimulus
is_a: IEV:0000294 ! Plant hormone medication

[Term]
id: IEV:0001581
name: Carbohydrate treatment
is_a: IEV:0000064 ! Organic chemical treatment

[Term]
id: IEV:0001582
name: Hexose treatment
is_a: IEV:0001581 ! Carbohydrate treatment

[Term]
id: IEV:0001583
name: Sucrose treatment
is_a: IEV:0001581 ! Carbohydrate treatment

[Term]
id: IEV:0001584
name: Fructose treatment
is_a: IEV:0001581 ! Carbohydrate treatment

[Term]
id: IEV:0001585
name: Glucose treatment
is_a: IEV:0001581 ! Carbohydrate treatment

[Term]
id: IEV:0001586
name: Anisomycin medication
is_a: IEV:0001567 ! Protein synthesis inhibitor medication

[Term]
id: IEV:0001587
name: Puromycin medication
is_a: IEV:0001567 ! Protein synthesis inhibitor medication

[Term]
id: IEV:0001588
name: Actinomycin medication
is_a: IEV:0001571 ! Transcription inhibitor medication

[Term]
id: IEV:0001589
name: Src family activation signaling
xref_analog: PubMed:15034556
is_a: IEV:0000458 ! Protein activation/inactivation signaling

[Term]
id: IEV:0001590
name: Src family inactivation signaling
xref_analog: PubMed:11781344
is_a: IEV:0000458 ! Protein activation/inactivation signaling
is_a: IEV:0000559 ! Negative regulation of Src family activation signaling

[Term]
id: IEV:0001591
name: Phosphorylation of Lck by non-receptor kinase and inactive conformational change
xref_analog: PubMed:15034556
is_a: IEV:0001612 ! Phosphorylation of Src family  by non-receptor kinase and inactive conformational change
relationship: part_of IEV:0001890 ! Lck inactivation signaling (through Csk)

[Term]
id: IEV:0001592
name: Dephosphorylation of Lck_p (autophosphorylated) by PTP
xref_analog: PubMed:15034556
is_a: IEV:0001611 ! Dephosphorylation of Src family  (autophosphorylated) by PTP
relationship: part_of IEV:0000513 ! Lck inactivation signaling (through PTP)

[Term]
id: IEV:0001593
name: Interaction in the inner space of the nuclear
is_a: IEV:0000537 ! Interaction in nucleus

[Term]
id: IEV:0001594
name: Dephosphorylation of Fyn_p (autophosphorylated) by PTP
xref_analog: PubMed:15034556
is_a: IEV:0001611 ! Dephosphorylation of Src family  (autophosphorylated) by PTP
relationship: part_of IEV:0000558 ! Fyn inactivation signaling (through PTP)

[Term]
id: IEV:0001595
name: Protein involved in DNA fragmentation and chromatin condensation signaling
is_obsolete: true

[Term]
id: IEV:0001596
name: Phosphorylation of Fyn by non-receptor kinase and inactive conformational change
xref_analog: PubMed:15034556
is_a: IEV:0001612 ! Phosphorylation of Src family  by non-receptor kinase and inactive conformational change
relationship: part_of IEV:0001891 ! Fyn inactivation signaling (through Csk)

[Term]
id: IEV:0001597
name: Phosphorylation of Src family by Ctk and inactive conformational change
xref_analog: PubMed:15034556
is_a: IEV:0001612 ! Phosphorylation of Src family  by non-receptor kinase and inactive conformational change

[Term]
id: IEV:0001598
name: Dephosphorylation of Fyn_p (phosphorylated in the C-terminal site) by PTP and active conformational change
xref_analog: PubMed:15034556
is_a: IEV:0001608 ! Dephosphorylation of Src family  (phosphorylated in the C-terminal site) by PTP and active conformational change
relationship: part_of IEV:0000535 ! Fyn activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001599
name: Dephosphorylation of Lck_p (phosphorylated in the C-terminal phosphorylation site) by PTP and active conformational change
xref_analog: PubMed:15034556
is_a: IEV:0001608 ! Dephosphorylation of Src family  (phosphorylated in the C-terminal site) by PTP and active conformational change
relationship: part_of IEV:0000519 ! Lck activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001600
name: Dephosphorylation of Src (phosphorylated in the C-terminal site) by SHP-1 and active conformational change
xref_analog: PubMed:15034556
xref_analog: PubMed:9261115
is_a: IEV:0001638 ! Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP and active conformational change

[Term]
id: IEV:0001601
name: Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP1D and active conformational change
xref_analog: PubMed:15034556
xref_analog: PubMed:7478513
is_a: IEV:0001638 ! Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP and active conformational change

[Term]
id: IEV:0001602
name: EndoG mediated signaling
relationship: part_of IEV:0001017 ! DNA fragmentation during apoptosis
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0001603
name: CAD signaling
relationship: part_of IEV:0000938 ! Caspase cascade (not through mitochondria)
relationship: part_of IEV:0001017 ! DNA fragmentation during apoptosis

[Term]
id: IEV:0001604
name: Gene expression of apoptotic factor by p53
is_a: IEV:0001110 ! Gene expression by p53
relationship: part_of IEV:0001114 ! p53 signaling pathway (through apoptotic factor)

[Term]
id: IEV:0001605
name: Nuclear import of EndoG
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001602 ! EndoG mediated signaling

[Term]
id: IEV:0001606
name: Src family activation signaling (through autophosphorylation and PTP)
is_a: IEV:0001589 ! Src family activation signaling

[Term]
id: IEV:0001607
name: Autophosphorylation of Src family and active conformational change
xref_analog: PubMed:15034556
is_a: IEV:0000481 ! Autophosphorylation in cytosol
relationship: part_of IEV:0001606 ! Src family activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001608
name: Dephosphorylation of Src family  (phosphorylated in the C-terminal site) by PTP and active conformational change
xref_analog: PubMed:15034556
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0001606 ! Src family activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001609
name: Fyn activation signaling
is_a: IEV:0001589 ! Src family activation signaling

[Term]
id: IEV:0001610
name: Lck activation signaling
is_a: IEV:0001589 ! Src family activation signaling

[Term]
id: IEV:0001611
name: Dephosphorylation of Src family  (autophosphorylated) by PTP
xref_analog: PubMed:15034556
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0001590 ! Src family inactivation signaling

[Term]
id: IEV:0001612
name: Phosphorylation of Src family  by non-receptor kinase and inactive conformational change
xref_analog: PubMed:15034556
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001590 ! Src family inactivation signaling

[Term]
id: IEV:0001613
name: Regulation of Fyn activation signaling
is_a: IEV:0000520 ! Regulation of Src family activation signaling
relationship: part_of IEV:0001609 ! Fyn activation signaling

[Term]
id: IEV:0001614
name: Negative regulation of Fyn activation signaling
is_a: IEV:0000559 ! Negative regulation of Src family activation signaling
is_a: IEV:0001613 ! Regulation of Fyn activation signaling

[Term]
id: IEV:0001615
name: Positive regulation of Fyn activation signaling
is_a: IEV:0000560 ! Positive regulation of Src family activation signaling
is_a: IEV:0001613 ! Regulation of Fyn activation signaling

[Term]
id: IEV:0001616
name: Regulation of Lck activation signaling
is_a: IEV:0000520 ! Regulation of Src family activation signaling
relationship: part_of IEV:0001610 ! Lck activation signaling

[Term]
id: IEV:0001617
name: Negative regulation of Lck activation signaling
is_a: IEV:0000559 ! Negative regulation of Src family activation signaling
is_a: IEV:0001616 ! Regulation of Lck activation signaling

[Term]
id: IEV:0001618
name: Positive regulation of Lck activation signaling
is_a: IEV:0000560 ! Positive regulation of Src family activation signaling
is_a: IEV:0001616 ! Regulation of Lck activation signaling

[Term]
id: IEV:0001619
name: Regulation of Src activation signaling
is_a: IEV:0000520 ! Regulation of Src family activation signaling
relationship: part_of IEV:0001222 ! Src activation signaling

[Term]
id: IEV:0001620
name: Negative regulation of Src activation signaling
is_a: IEV:0001619 ! Regulation of Src activation signaling

[Term]
id: IEV:0001621
name: Positive regulation of Src activation signaling
is_a: IEV:0001619 ! Regulation of Src activation signaling

[Term]
id: IEV:0001622
name: Regulation of Src family activation signaling (autophosphorylation and PTP)
is_a: IEV:0000520 ! Regulation of Src family activation signaling
relationship: part_of IEV:0001606 ! Src family activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001623
name: Negative regulation of Src family activation signaling (autophosphorylation and PTP)
is_a: IEV:0000559 ! Negative regulation of Src family activation signaling
is_a: IEV:0001622 ! Regulation of Src family activation signaling (autophosphorylation and PTP)

[Term]
id: IEV:0001624
name: Positive regulation of Src family activation signaling (autophosphorylation and PTP)
is_a: IEV:0000560 ! Positive regulation of Src family activation signaling
is_a: IEV:0001622 ! Regulation of Src family activation signaling (autophosphorylation and PTP)

[Term]
id: IEV:0001625
name: Regulation of src activation signaling (through Estrogen receptor)
is_a: IEV:0001619 ! Regulation of Src activation signaling
relationship: part_of IEV:0001313 ! Src activation signaling (through Estrogen receptor)

[Term]
id: IEV:0001626
name: Negative regulation of src activation signaling (through Estrogen receptor)
is_a: IEV:0001620 ! Negative regulation of Src activation signaling
is_a: IEV:0001625 ! Regulation of src activation signaling (through Estrogen receptor)

[Term]
id: IEV:0001627
name: Positive regulation of src activation signaling (through Estrogen receptor)
is_a: IEV:0001621 ! Positive regulation of Src activation signaling
is_a: IEV:0001625 ! Regulation of src activation signaling (through Estrogen receptor)

[Term]
id: IEV:0001628
name: Regulation of Fyn activation signaling (through autophosphorylation and PTP)
is_a: IEV:0001613 ! Regulation of Fyn activation signaling
relationship: part_of IEV:0000535 ! Fyn activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001629
name: Negative regulation of Fyn activation signaling (through autophosphorylation and PTP)
is_a: IEV:0001614 ! Negative regulation of Fyn activation signaling
is_a: IEV:0001628 ! Regulation of Fyn activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001630
name: Positive regulation of Fyn activation signaling (autophosphorylation and PTP)
is_a: IEV:0001615 ! Positive regulation of Fyn activation signaling
is_a: IEV:0001628 ! Regulation of Fyn activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001631
name: Regulation of Lck activation signaling (autophosphorylation and PTP)
is_a: IEV:0001616 ! Regulation of Lck activation signaling
relationship: part_of IEV:0000519 ! Lck activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001632
name: Negative regulation of (dephosphorylation of Lck) Lck activation signaling (autophosphorylation and PTP)
is_a: IEV:0001617 ! Negative regulation of Lck activation signaling
is_a: IEV:0001896 ! Negative regulation of Lck activation signaling (autophosphorylation and PTP)

[Term]
id: IEV:0001633
name: Positive regulation of Lck activation signaling (autophosphorylation and PTP)
is_a: IEV:0001618 ! Positive regulation of Lck activation signaling
is_a: IEV:0001631 ! Regulation of Lck activation signaling (autophosphorylation and PTP)

[Term]
id: IEV:0001634
name: Fyn inactivation signaling
is_a: IEV:0001590 ! Src family inactivation signaling

[Term]
id: IEV:0001635
name: Lck inactivation signaling
is_a: IEV:0001590 ! Src family inactivation signaling
is_a: IEV:0001617 ! Negative regulation of Lck activation signaling

[Term]
id: IEV:0001636
name: Src activation signaling (through autophosphorylation and PTP)
is_a: IEV:0001222 ! Src activation signaling
is_a: IEV:0001606 ! Src family activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001637
name: Autophosphorylation of Src and active conformational change
def: "p416" [PubMed:11804588]
xref_analog: PubMed:11804588
xref_analog: PubMed:15034556
is_a: IEV:0001607 ! Autophosphorylation of Src family and active conformational change
relationship: part_of IEV:0001636 ! Src activation signaling (through autophosphorylation and PTP)
relationship: part_of IEV:0002081 ! Rap1 activation signaling (through cAMP, PKA, Cbl and C3G)

[Term]
id: IEV:0001638
name: Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP and active conformational change
xref_analog: PubMed:15034556
is_a: IEV:0001608 ! Dephosphorylation of Src family  (phosphorylated in the C-terminal site) by PTP and active conformational change
relationship: part_of IEV:0001636 ! Src activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001639
name: Regulation of Src activation signaling (through autophosphorylation and PTP)
is_a: IEV:0001619 ! Regulation of Src activation signaling
is_a: IEV:0001636 ! Src activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001640
name: Negative regulation of Src activation signaling (through autophosphorylation and PTP)
is_a: IEV:0001620 ! Negative regulation of Src activation signaling
is_a: IEV:0001639 ! Regulation of Src activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001641
name: Positive regulation of Src activation signaling (through autophosphorylation and PTP)
is_a: IEV:0001621 ! Positive regulation of Src activation signaling
is_a: IEV:0001639 ! Regulation of Src activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001642
name: Src inactivation signaling
xref_analog: PubMed:15034556
is_a: IEV:0001590 ! Src family inactivation signaling

[Term]
id: IEV:0001643
name: Dephosphorylation of Src (autophosphorylated) by PTP
xref_analog: PubMed:15034556
is_a: IEV:0001611 ! Dephosphorylation of Src family  (autophosphorylated) by PTP
is_a: IEV:0001892 ! Src inactivation signaling (through PTP)

[Term]
id: IEV:0001644
name: Phosphorylation of Src by non-receptor kinase and inactive conformational change
xref_analog: PubMed:15034556
is_a: IEV:0001612 ! Phosphorylation of Src family  by non-receptor kinase and inactive conformational change
relationship: part_of IEV:0001893 ! Src inactivation signaling (through non-receptor kinase)

[Term]
id: IEV:0001645
name: Phosphorylation of Src by Csk and inactive conformational change
xref_analog: PubMed:15034556
xref_analog: PubMed:2480346
is_a: IEV:0001644 ! Phosphorylation of Src by non-receptor kinase and inactive conformational change

[Term]
id: IEV:0001646
name: Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP alpha and active conformational change
xref_analog: PubMed:15034556
is_a: IEV:0001638 ! Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP and active conformational change

[Term]
id: IEV:0001647
name: Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP lambda and active conformational change
xref_analog: PubMed:15034556
is_a: IEV:0001638 ! Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP and active conformational change

[Term]
id: IEV:0001648
name: Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP1B and active conformational change
xref_analog: PubMed:15034556
is_a: IEV:0001638 ! Dephosphorylation of Src (phosphorylated in the C-terminal site) by PTP and active conformational change

[Term]
id: IEV:0001649
name: Permeabilization of mitochondria and Translocation of EndoG from mitochondria to cytosol
is_a: IEV:0000985 ! Translocation from mitochondria to cytosol
relationship: part_of IEV:0001602 ! EndoG mediated signaling

[Term]
id: IEV:0001650
name: Gene expression of BAK by p53
is_a: IEV:0001604 ! Gene expression of apoptotic factor by p53

[Term]
id: IEV:0001651
name: Gene expression of BID by p53
is_a: IEV:0001604 ! Gene expression of apoptotic factor by p53

[Term]
id: IEV:0001652
name: Gene expression of NOXA by p53
is_a: IEV:0001604 ! Gene expression of apoptotic factor by p53

[Term]
id: IEV:0001653
name: Gene expression of PUMA by p53
is_a: IEV:0001604 ! Gene expression of apoptotic factor by p53

[Term]
id: IEV:0001654
name: Nuclear export of mRNA (BAK)
is_a: IEV:0001650 ! Gene expression of BAK by p53

[Term]
id: IEV:0001655
name: Nuclear export of mRNA (BID)
is_a: IEV:0001651 ! Gene expression of BID by p53

[Term]
id: IEV:0001656
name: Nuclear export of mRNA (NOXA)
is_a: IEV:0001652 ! Gene expression of NOXA by p53

[Term]
id: IEV:0001657
name: Nuclear export of mRNA (PUMA)
is_a: IEV:0001653 ! Gene expression of PUMA by p53

[Term]
id: IEV:0001658
name: Transcription of BAK by p53
is_a: IEV:0001650 ! Gene expression of BAK by p53
is_a: IEV:0001661 ! Transcription of apoptotic factor by p53

[Term]
id: IEV:0001659
name: Transcription of BID by p53
is_a: IEV:0001651 ! Gene expression of BID by p53
is_a: IEV:0001661 ! Transcription of apoptotic factor by p53

[Term]
id: IEV:0001660
name: Translation of NOXA
is_a: IEV:0001652 ! Gene expression of NOXA by p53

[Term]
id: IEV:0001661
name: Transcription of apoptotic factor by p53
is_a: IEV:0001144 ! Transcription by p53

[Term]
id: IEV:0001662
name: Translation of apoptotic factor
is_a: IEV:0000219 ! Translation

[Term]
id: IEV:0001663
name: Translation of BAK
is_a: IEV:0001650 ! Gene expression of BAK by p53

[Term]
id: IEV:0001664
name: Translation of BID
is_a: IEV:0001651 ! Gene expression of BID by p53

[Term]
id: IEV:0001665
name: Translation of PUMA
is_a: IEV:0001653 ! Gene expression of PUMA by p53

[Term]
id: IEV:0001666
name: Permeabilization of mitochondria and Translocation of OMI from mitochondria to cytosol
is_a: IEV:0000985 ! Translocation from mitochondria to cytosol
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0001667
name: Bcl-2/Bcl-xL inactivation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0000939 ! Caspase cascade (through mitochondria)

[Term]
id: IEV:0001668
name: Relocation of free tBID to cytosol
relationship: part_of IEV:0000941 ! BID activation signaling

[Term]
id: IEV:0001669
name: Positive regulation pathway
is_a: IEV:0000145 ! Regulation pathway

[Term]
id: IEV:0001670
name: Negative regulation pathway
is_a: IEV:0000145 ! Regulation pathway

[Term]
id: IEV:0001671
name: Negative regulation of PDGF signaling pathway
is_a: IEV:0001406 ! Regulation of PDGF signaling pathway
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0001672
name: Positive regulation of PDGF signaling pathway
is_a: IEV:0001406 ! Regulation of PDGF signaling pathway
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0001673
name: Negative regulation of Toll-like receptor pathway
def: "Any process that stops, prevents or reduces the rate, frequency or extent of the Tl signaling pathway." [GO:0045751]
xref_analog: GO:0045751
is_a: IEV:0001400 ! Regulation of Toll-like receptor pathway
is_a: IEV:0001670 ! Negative regulation pathway

[Term]
id: IEV:0001674
name: Positive regulation of Toll-like receptor pathway
def: "Any process that activates or increases the rate, frequency or extent of the Tl signaling pathway." [GO:0045752]
xref_analog: GO:0045752
is_a: IEV:0001400 ! Regulation of Toll-like receptor pathway
is_a: IEV:0001669 ! Positive regulation pathway

[Term]
id: IEV:0001675
name: Regulation of Wnt signaling pathway
def: "Any process that modulates the frequency, rate or extent of the activity of the Wnt receptor mediated signal transduction pathway." [GO:0030111]
xref_analog: GO:0030111
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001676
name: Negative regulation of Wnt signaling pathway
def: "Any process that stops, prevents or reduces the rate, frequency or extent of Wnt receptor signaling pathway activity." [GO:0030178]
xref_analog: GO:0030178
is_a: IEV:0001670 ! Negative regulation pathway
is_a: IEV:0001675 ! Regulation of Wnt signaling pathway

[Term]
id: IEV:0001677
name: Positive regulation of Wnt signaling pathway
def: "Any process that activates or increases the rate, frequency or extent of Wnt receptor signaling pathway activity." [GO:0030177]
xref_analog: GO:0030177
is_a: IEV:0001669 ! Positive regulation pathway
is_a: IEV:0001675 ! Regulation of Wnt signaling pathway

[Term]
id: IEV:0001678
name: Caloric restriction
xref_analog: PubMed:15205477
is_a: IEV:0001679 ! Caloric treatment
relationship: part_of IEV:0001686 ! Caloric restriction - cell survival signaling

[Term]
id: IEV:0001679
name: Caloric treatment
is_a: IEV:0000387 ! Treatment

[Term]
id: IEV:0001680
name: Deacetylation of DNA repair factor Ku70 by SIRT1
xref_analog: PubMed:15205477
is_a: IEV:0001683 ! Deacetylation in nucleus
relationship: part_of IEV:0001686 ! Caloric restriction - cell survival signaling

[Term]
id: IEV:0001681
name: Deacetylation
def: "N6-acetyl-L-lysine or S-acetyl-L-cysteine are cleaved and return K or C residues. " [MI:0197]
xref_analog: MI:0197
is_a: IEV:0000184 ! Hydrolysis

[Term]
id: IEV:0001682
name: Deacetylation in cytosol
is_a: IEV:0001681 ! Deacetylation

[Term]
id: IEV:0001683
name: Deacetylation in nucleus
is_a: IEV:0001681 ! Deacetylation

[Term]
id: IEV:0001684
name: Deacetylation in unidentified cellular location
is_a: IEV:0001681 ! Deacetylation

[Term]
id: IEV:0001685
name: Regulation of caloric restriction - cell survival signaling
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0001686 ! Caloric restriction - cell survival signaling

[Term]
id: IEV:0001686
name: Caloric restriction - cell survival signaling
is_a: IEV:0001842 ! Signal transduction pathway
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0001687
name: Regulation of IGF signaling pathway
def: "Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling." [GO:0043567]
related_synonym: "regulation of IGF receptor signaling pathway" [GO:0043567]
related_synonym: "regulation of insulin-like growth factor receptor signaling pathwa" [GO:0043567]
xref_analog: GO:0043567
is_a: IEV:0000834 ! Regulation of RTK signaling pathway
relationship: part_of IEV:0000454 ! IGF signaling pathway

[Term]
id: IEV:0001688
name: Negative regulation of IGF signaling pathway
def: "Any process that stops, prevents or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling." [GO:0043569]
related_synonym: "negative regulation of IGF receptor signaling pathway" [GO:0043569]
related_synonym: "negative regulation of insulin-like growth factor receptor signaling pathway" [GO:0043569]
xref_analog: GO:0043569
is_a: IEV:0001670 ! Negative regulation pathway
is_a: IEV:0001687 ! Regulation of IGF signaling pathway

[Term]
id: IEV:0001689
name: Positive regulation of IGF signaling pathway
def: "Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling." [GO:0043568]
related_synonym: "positive regulation of IGF receptor signaling pathway" [GO:0043568]
related_synonym: "positive regulation of insulin-like growth factor receptor signaling pathway" [GO:0043568]
xref_analog: GO:0043568
is_a: IEV:0001669 ! Positive regulation pathway
is_a: IEV:0001687 ! Regulation of IGF signaling pathway

[Term]
id: IEV:0001690
name: Negative regulation of caloric restriction - cell survival signaling
is_a: IEV:0001670 ! Negative regulation pathway
is_a: IEV:0001685 ! Regulation of caloric restriction - cell survival signaling

[Term]
id: IEV:0001691
name: Positive regulation of caloric restriction - cell survival signaling
is_a: IEV:0001669 ! Positive regulation pathway
is_a: IEV:0001685 ! Regulation of caloric restriction - cell survival signaling

[Term]
id: IEV:0001692
name: Translocation of Bax from mitochondria membrane to cytosol
xref_analog: PubMed:15205477
is_a: IEV:0000175 ! Translocation from mitochondria membrane to cytosol
relationship: part_of IEV:0001686 ! Caloric restriction - cell survival signaling

[Term]
id: IEV:0001693
name: Endothelin receptor signaling
xref_analog: PubMed:11585834
is_a: IEV:0000661 ! GPCR signaling pathway
relationship: part_of IEV:0001822 ! Vasoconstriction
relationship: part_of IEV:0001824 ! Smooth muscle cell differentiation

[Term]
id: IEV:0001694
name: Binding of endothelin and endothelin receptor
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001693 ! Endothelin receptor signaling

[Term]
id: IEV:0001695
name: Regulation of endothelin receptor signaling
is_a: IEV:0000668 ! Regulation of heterotrimeric GPCR signaling pathway
relationship: part_of IEV:0001693 ! Endothelin receptor signaling

[Term]
id: IEV:0001696
name: Negative regulation of endothelin receptor signaling
is_a: IEV:0000669 ! Negative regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0001695 ! Regulation of endothelin receptor signaling

[Term]
id: IEV:0001697
name: Positive regulation of endothelin receptor signaling
is_a: IEV:0000670 ! Positive regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0001695 ! Regulation of endothelin receptor signaling

[Term]
id: IEV:0001698
name: Binding of 14-3-3 and HDAC5/7
xref_analog: PubMed:11509672
xref_analog: PubMed:11585834
xref_analog: PubMed:15166223
is_a: IEV:0001730 ! Binding in cytosol and/or nucleus
relationship: part_of IEV:0001866 ! HDAC nuclear export signaling

[Term]
id: IEV:0001699
name: AKT signaling
def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B, which occurs as a result of a single trigger reaction or compound." [GO:0043491]
related_synonym: "AKT signaling cascade" [GO:0043491]
related_synonym: "PKB signaling cascade" [GO:0043491]
related_synonym: "protein kinase B signaling cascade" [GO:0043491]
xref_analog: GO:0043491
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0001700
name: Phosphorylation of HDAC5/7 by CaMK
xref_analog: PubMed:11509672
xref_analog: PubMed:11585834
xref_analog: PubMed:15166223
is_a: IEV:0001735 ! Phosphorylation in cytosol and/or nucleus
relationship: part_of IEV:0001866 ! HDAC nuclear export signaling

[Term]
id: IEV:0001701
name: Dephosphorylation of HDAC5/7 by protein phosphatase
is_a: IEV:0001729 ! Dephosphorylation in cytosol and/or  nucleus
relationship: part_of IEV:0001865 ! HDAC nuclear import signaling

[Term]
id: IEV:0001702
name: Nuclear export of 14-3-3:HDAC5/7:Crm1
xref_analog: PubMed:11509672
xref_analog: PubMed:11585834
is_a: IEV:0000019 ! Nuclear export
relationship: part_of IEV:0001866 ! HDAC nuclear export signaling

[Term]
id: IEV:0001703
name: Binding of HDAC5/7 and MEF2
xref_analog: PubMed:11509672
xref_analog: PubMed:11585834
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001865 ! HDAC nuclear import signaling

[Term]
id: IEV:0001704
name: Dissociation of 14-3-3 and HDAC5/7
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0001865 ! HDAC nuclear import signaling

[Term]
id: IEV:0001705
name: Nuclear import of HDAC5/7
xref_analog: PubMed:11509672
xref_analog: PubMed:11585834
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001865 ! HDAC nuclear import signaling

[Term]
id: IEV:0001707
name: AKT(PKB)-caspase signaling
is_a: IEV:0001699 ! AKT signaling
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0001709
name: AKT(PKB)-FKHRL1 signaling
is_a: IEV:0001699 ! AKT signaling
relationship: part_of IEV:0000153 ! Cell survival (Inhibition of apoptosis)

[Term]
id: IEV:0001710
name: Phosphorylation of FKHRL1 by AKT
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001709 ! AKT(PKB)-FKHRL1 signaling

[Term]
id: IEV:0001716
name: Nuclear export of 14-3-3:HDAC5:Crm1
xref_analog: PubMed:11509672
is_a: IEV:0001702 ! Nuclear export of 14-3-3:HDAC5/7:Crm1

[Term]
id: IEV:0001717
name: Nuclear export of 14-3-3:HDAC7:Crm1
xref_analog: PubMed:11585834
is_a: IEV:0001702 ! Nuclear export of 14-3-3:HDAC5/7:Crm1

[Term]
id: IEV:0001718
name: Binding of HDAC5 and MEF2
xref_analog: PubMed:11509672
is_a: IEV:0001703 ! Binding of HDAC5/7 and MEF2

[Term]
id: IEV:0001719
name: Nuclear import of HDAC5:importin alpha
xref_analog: PubMed:11509672
is_obsolete: true

[Term]
id: IEV:0001720
name: Binding of HDAC7 and MEF2
xref_analog: PubMed:11585834
is_a: IEV:0001703 ! Binding of HDAC5/7 and MEF2

[Term]
id: IEV:0001721
name: Dissociation of 14-3-3 and HDAC5
xref_analog: PubMed:11509672
is_a: IEV:0001704 ! Dissociation of 14-3-3 and HDAC5/7

[Term]
id: IEV:0001722
name: Dissociation of 14-3-3 and HDAC7
xref_analog: PubMed:11585834
is_a: IEV:0001704 ! Dissociation of 14-3-3 and HDAC5/7

[Term]
id: IEV:0001723
name: Dephosphorylation of HDAC7 by protein phosphatase
xref_analog: PubMed:11585834
xref_analog: PubMed:15166223
is_a: IEV:0000022 ! Dephosphorylation in cytosol
is_a: IEV:0001050 ! Dephosphorylation in the inner space or the nuclear
is_a: IEV:0001701 ! Dephosphorylation of HDAC5/7 by protein phosphatase

[Term]
id: IEV:0001724
name: Dephosphorylation of HDAC5 by protein phosphatase
xref_analog: PubMed:11509672
is_a: IEV:0000022 ! Dephosphorylation in cytosol
is_a: IEV:0001701 ! Dephosphorylation of HDAC5/7 by protein phosphatase

[Term]
id: IEV:0001725
name: Binding of TRAF2 and MAPKKK
xref_analog: PubMed:10485710
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000113 ! TNFR1 signaling pathway (through NF-kappaB cascade)
relationship: part_of IEV:0000802 ! TNFR2 signaling pathway (through IKK-NF-kappaB cascade)

[Term]
id: IEV:0001726
name: Binding of TRAF2 and NIK
xref_analog: PubMed:10485710
is_a: IEV:0001725 ! Binding of TRAF2 and MAPKKK

[Term]
id: IEV:0001727
name: AKT(PKB)-IKK signaling
is_a: IEV:0001699 ! AKT signaling

[Term]
id: IEV:0001728
name: Phosphorylation of IKK alpha by AKT(PKB)
relationship: part_of IEV:0001727 ! AKT(PKB)-IKK signaling

[Term]
id: IEV:0001729
name: Dephosphorylation in cytosol and/or  nucleus
is_a: IEV:0000011 ! Dephosphorylation

[Term]
id: IEV:0001730
name: Binding in cytosol and/or nucleus
is_a: IEV:0000004 ! Binding

[Term]
id: IEV:0001731
name: Binding of 14-3-3 and HDAC5
def: "CaMK-mediated nuclear export of HDAC5 appears to require binding of 14-3-3 to Ser-259 and Ser-498 in its amino terminus. Indeed, substitution of these serines with alanines blocks both 14-3-3 binding and nuclear export of HDAC5. However, association with 14-3-3 alone is not sufficient to localize HDAC5 in the cytoplasm, since NES mutants of HDAC5 associate with 14-3-3 in a CaMK-dependent manner but remain in the nucleus." [PubMed:11509672]
xref_analog: IMR000117:histone deacetylase 5
xref_analog: PubMed:11509672
xref_analog: Uniprot:Q9UQL6
is_a: IEV:0001041 ! Binding in inner space of nucleus
is_a: IEV:0001698 ! Binding of 14-3-3 and HDAC5/7

[Term]
id: IEV:0001732
name: Binding of 14-3-3 and HDAC7
xref_analog: PubMed:11585834
xref_analog: PubMed:15166223
is_a: IEV:0001698 ! Binding of 14-3-3 and HDAC5/7

[Term]
id: IEV:0001733
name: Phosphorylation of HDAC5 by CaMK
xref_analog: PubMed:11509672
is_a: IEV:0001082 ! Phosphorylation in the inner space of the nuclear
is_a: IEV:0001700 ! Phosphorylation of HDAC5/7 by CaMK

[Term]
id: IEV:0001734
name: Phosphorylation of HDAC7 by CaMKI
xref_analog: PubMed:11585834
xref_analog: PubMed:15166223
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0001082 ! Phosphorylation in the inner space of the nuclear
is_a: IEV:0001700 ! Phosphorylation of HDAC5/7 by CaMK

[Term]
id: IEV:0001735
name: Phosphorylation in cytosol and/or nucleus
is_a: IEV:0000005 ! Phosphorylation

[Term]
id: IEV:0001736
name: Binding of AKT and GSK3beta
xref_analog: PubMed:11278246
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001737
name: Gene expression of beta-TrCP
is_a: IEV:0000182 ! Gene expression
relationship: part_of IEV:0001813 ! Negative feedback regulation of Wnt signaling pathway (through beta-TrCP)

[Term]
id: IEV:0001738
name: Binding of APC and beta catenin
xref_analog: PubMed:8259519
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001739 ! Beta catenin degradation signaling

[Term]
id: IEV:0001739
name: Beta catenin degradation signaling
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [GO:0031146]
related_synonym: "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process" []
related_synonym: "SCF-dependent proteasomal ubiquitin-dependent protein degradation" []
xref_analog: GO:0031146
is_a: IEV:0000122 ! Proteasome mediated protein degradation signaling
is_a: IEV:0001676 ! Negative regulation of Wnt signaling pathway
relationship: part_of IEV:0001813 ! Negative feedback regulation of Wnt signaling pathway (through beta-TrCP)

[Term]
id: IEV:0001741
name: Proteasome degradation of beta catenin by 26S proteasome
is_a: IEV:0000021 ! Proteasome degradation in cytosol
relationship: part_of IEV:0001739 ! Beta catenin degradation signaling

[Term]
id: IEV:0001742
name: Phosphorylation of beta catenin by GSK3beta
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001739 ! Beta catenin degradation signaling

[Term]
id: IEV:0001743
name: Phosphorylation of GSK3beta by AKT
xref_analog: PubMed:11278246
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0001745 ! AKT(PKB)-GSK3beta signaling

[Term]
id: IEV:0001744
name: GSK3beta inactivation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling
is_a: IEV:0001677 ! Positive regulation of Wnt signaling pathway

[Term]
id: IEV:0001745
name: AKT(PKB)-GSK3beta signaling
is_a: IEV:0001699 ! AKT signaling
is_a: IEV:0001744 ! GSK3beta inactivation signaling

[Term]
id: IEV:0001746
name: Regulation of EPO signaling pathway
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000867 ! EPO signaling pathway

[Term]
id: IEV:0001747
name: Negative regulation of EPO signaling pathway
is_a: IEV:0001670 ! Negative regulation pathway
is_a: IEV:0001746 ! Regulation of EPO signaling pathway

[Term]
id: IEV:0001748
name: Positive regulation of EPO signaling pathway
is_a: IEV:0001669 ! Positive regulation pathway
is_a: IEV:0001746 ! Regulation of EPO signaling pathway

[Term]
id: IEV:0001749
name: Regulation of Growth hormone signaling pathway (JAK2 STAT5)
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000133 ! Growth hormone signaling pathway (JAK2, STAT5)

[Term]
id: IEV:0001750
name: Negative regulation of Growth hormone signaling pathway (JAK2 STAT5)
is_a: IEV:0001670 ! Negative regulation pathway
is_a: IEV:0001749 ! Regulation of Growth hormone signaling pathway (JAK2 STAT5)

[Term]
id: IEV:0001751
name: Positive regulation of Growth hormone  signaling pathway (JAK2 STAT5)
is_a: IEV:0001669 ! Positive regulation pathway
is_a: IEV:0001749 ! Regulation of Growth hormone signaling pathway (JAK2 STAT5)

[Term]
id: IEV:0001752
name: Regulation of JNK signaling (Angiotensin induced)
is_a: IEV:0000550 ! Regulation of JAK STAT pathway
relationship: part_of IEV:0000062 ! JNK signaling (Angiotensin induced)

[Term]
id: IEV:0001753
name: Negative regulation of JNK signaling (Angiotensin induced)
is_a: IEV:0001670 ! Negative regulation pathway
is_a: IEV:0001752 ! Regulation of JNK signaling (Angiotensin induced)

[Term]
id: IEV:0001754
name: Positive regulation of JNK signaling (Angiotensin induced)
is_a: IEV:0001669 ! Positive regulation pathway
is_a: IEV:0001752 ! Regulation of JNK signaling (Angiotensin induced)

[Term]
id: IEV:0001755
name: Regulation of TPO signaling pathway (through JAK STAT pathway)
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0001233 ! TPO signaling pathway (JAK2, STAT3)

[Term]
id: IEV:0001756
name: Negative regulation of TPO signaling pathway (through JAK STAT pathway)
is_a: IEV:0001670 ! Negative regulation pathway
is_a: IEV:0001755 ! Regulation of TPO signaling pathway (through JAK STAT pathway)

[Term]
id: IEV:0001757
name: Positive regulation of TPO signaling pathway (through JAK STAT pathway)
is_a: IEV:0001669 ! Positive regulation pathway
is_a: IEV:0001755 ! Regulation of TPO signaling pathway (through JAK STAT pathway)

[Term]
id: IEV:0001761
name: Sumoylation of Smad3 by PIASy
xref_analog: PubMed:12815042
is_a: IEV:0001055 ! SUMOylation in cytosol
relationship: part_of IEV:0001762 ! Negative feedback regulation pathway of TGF beta superfamily signaling by (Smad3 sumoylation by PIAS)

[Term]
id: IEV:0001762
name: Negative feedback regulation pathway of TGF beta superfamily signaling by (Smad3 sumoylation by PIAS)
is_a: IEV:0000885 ! Negative feedback regulation pathway of TGF beta superfamily signaling

[Term]
id: IEV:0001763
name: Gene expression of PIASy (induced by TGF-beta)
def: "Hep3B cells" [PubMed:12815042]
xref_analog: PubMed:12815042
is_a: IEV:0000182 ! Gene expression
relationship: part_of IEV:0001762 ! Negative feedback regulation pathway of TGF beta superfamily signaling by (Smad3 sumoylation by PIAS)

[Term]
id: IEV:0001765
name: Sumoylation of STAT1 by PIAS
xref_analog: PubMed:12855578
is_a: IEV:0001055 ! SUMOylation in cytosol
relationship: part_of IEV:0001767 ! Negative regulation of JAK STAT pathway by (STAT sumoylation by PIAS1/3)
relationship: part_of IEV:0001830 ! Negative regulation of transcription in JAK STAT pathway by (STAT sumoylation by PIAS)

[Term]
id: IEV:0001767
name: Negative regulation of JAK STAT pathway by (STAT sumoylation by PIAS1/3)
is_a: IEV:0000150 ! Negative regulation of JAK STAT pathway

[Term]
id: IEV:0001769
name: Binding of Androgen and Androgen receptor
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001770
name: Binding of Androgen receptor and responsive element
is_a: IEV:0002098 ! Binding of transcriptional factor and responsive element
relationship: part_of IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001771
name: Nuclear import of Androgen
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001772
name: Transcription by Androgen receptor
relationship: part_of IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001773
name: Translocation of Androgen from extracellular to cytosol
is_a: IEV:0001203 ! Translocation from extracellular to cytosol
relationship: part_of IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001774
name: Binding of Androgen receptor and Hsp90
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001775
name: Nuclear import of Androgen receptor:Hsp90
is_a: IEV:0000018 ! Nuclear import
relationship: part_of IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001776
name: Regulation of Steroid receptor signaling
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0001231 ! Steroid receptor signaling pathway

[Term]
id: IEV:0001777
name: Negative regulation of Steroid receptor signaling pathway
is_a: IEV:0001670 ! Negative regulation pathway
is_a: IEV:0001776 ! Regulation of Steroid receptor signaling

[Term]
id: IEV:0001778
name: Positive regulation of Steroid receptor signaling pathway
is_a: IEV:0001669 ! Positive regulation pathway
is_a: IEV:0001776 ! Regulation of Steroid receptor signaling

[Term]
id: IEV:0001779
name: Regulation of Estrogen receptor signaling pathway
is_a: IEV:0001776 ! Regulation of Steroid receptor signaling
relationship: part_of IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001780
name: Regulation of Androgen receptor signaling pathway
is_a: IEV:0001776 ! Regulation of Steroid receptor signaling
relationship: part_of IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001781
name: Negative regulation of Androgen receptor signaling pathway
is_a: IEV:0001777 ! Negative regulation of Steroid receptor signaling pathway
is_a: IEV:0001780 ! Regulation of Androgen receptor signaling pathway

[Term]
id: IEV:0001782
name: Positive regulation of Androgen receptor signaling pathway
is_a: IEV:0001778 ! Positive regulation of Steroid receptor signaling pathway
is_a: IEV:0001780 ! Regulation of Androgen receptor signaling pathway

[Term]
id: IEV:0001783
name: Negative regulation of Estrogen receptor signaling pathway
is_a: IEV:0001777 ! Negative regulation of Steroid receptor signaling pathway
is_a: IEV:0001779 ! Regulation of Estrogen receptor signaling pathway

[Term]
id: IEV:0001784
name: Positive regulation of Estrogen receptor signaling pathway
is_a: IEV:0001778 ! Positive regulation of Steroid receptor signaling pathway
is_a: IEV:0001779 ! Regulation of Estrogen receptor signaling pathway

[Term]
id: IEV:0001785
name: Binding of Androgen receptor and PIASy
xref_analog: PubMed:14981544
is_a: IEV:0001730 ! Binding in cytosol and/or nucleus
relationship: part_of IEV:0001786 ! Negative regulation of Androgen receptor signaling pathway by PIAS-mediated repression of Androgen receptor

[Term]
id: IEV:0001786
name: Negative regulation of Androgen receptor signaling pathway by PIAS-mediated repression of Androgen receptor
is_a: IEV:0001781 ! Negative regulation of Androgen receptor signaling pathway

[Term]
id: IEV:0001787
name: Sumoylation of Androgen receptor by PIASy
xref_analog: PubMed:14981544
relationship: part_of IEV:0001786 ! Negative regulation of Androgen receptor signaling pathway by PIAS-mediated repression of Androgen receptor

[Term]
id: IEV:0001788
name: Binding of Androgen receptor and HDAC
xref_analog: PubMed:14981544
is_a: IEV:0000015 ! Binding in nucleus
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001786 ! Negative regulation of Androgen receptor signaling pathway by PIAS-mediated repression of Androgen receptor

[Term]
id: IEV:0001789
name: Homodimerization of Androgen receptor
is_a: IEV:0000015 ! Binding in nucleus
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001232 ! Androgen receptor signaling pathway

[Term]
id: IEV:0001790
name: Homodimerization of Estrogen receptor
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000162 ! Estrogen receptor signaling pathway

[Term]
id: IEV:0001791
name: Regulation of calcineurin activation signaling
is_a: IEV:0000145 ! Regulation pathway
is_a: IEV:0001670 ! Negative regulation pathway
is_a: IEV:0001796 ! Regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
relationship: part_of IEV:0001303 ! Calcineurin activation signaling

[Term]
id: IEV:0001792
name: Negative regulation of calcineurin activation signaling
is_a: IEV:0001791 ! Regulation of calcineurin activation signaling
is_a: IEV:0001797 ! Negative regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0001793
name: Positive regulation of calcineurin activation signaling
is_a: IEV:0001669 ! Positive regulation pathway
is_a: IEV:0001791 ! Regulation of calcineurin activation signaling
is_a: IEV:0001798 ! Positive regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0001794
name: Binding of calcineurin and FK506
relationship: part_of IEV:0001792 ! Negative regulation of calcineurin activation signaling

[Term]
id: IEV:0001795
name: Binding of calcineurin and CSK
relationship: part_of IEV:0001792 ! Negative regulation of calcineurin activation signaling

[Term]
id: IEV:0001796
name: Regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
is_a: IEV:0001374 ! Regulation of T cell receptor signaling pathway

[Term]
id: IEV:0001797
name: Negative regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
is_a: IEV:0001375 ! Negative regulation of T cell receptor signaling pathway
is_a: IEV:0001796 ! Regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0001798
name: Positive regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)
is_a: IEV:0001376 ! Positive regulation of T cell receptor signaling pathway
is_a: IEV:0001796 ! Regulation of CD4 T cell receptor signaling (through PLC gamma, calcineurin and NF-AT)

[Term]
id: IEV:0001799
name: Regulation of Bad activation signaling
relationship: part_of IEV:0000406 ! Bad activation signaling

[Term]
id: IEV:0001800
name: Negative regulation of Bad activation signaling
is_a: IEV:0001799 ! Regulation of Bad activation signaling

[Term]
id: IEV:0001801
name: Positive regulation of Bad activation signaling
is_a: IEV:0001799 ! Regulation of Bad activation signaling

[Term]
id: IEV:0001802
name: Binding of AKT and Hsp90
xref_analog: PubMed:10995457
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001861 ! Negative regulation of (dephosphorylation of AKT(PKB) in negative regulation of AKT(PKB) activation signaling)
relationship: part_of IEV:0001862 ! Positive regulation of (phosphorylation of AKT(PKB) in AKT(PKB) activation signaling

[Term]
id: IEV:0001803
name: Dephosphorylation of AKT(PKB) by PP2A
xref_analog: PubMed:10995457
relationship: part_of IEV:0001848 ! Negative regulation of (phosphorylation of AKT(PKB)) in AKT(PKB) activation signaling

[Term]
id: IEV:0001805
name: Binding of Naked and DSH
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001806
name: Binding of Idax and DSH
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001807
name: TCF phosphorylation signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling
is_a: IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001808
name: Binding of TAB1 and TAK1
xref_analog: PubMed:14687659
xref_analog: PubMed:15733830
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000090 ! TGF beta super family signaling pathway
relationship: part_of IEV:0001807 ! TCF phosphorylation signaling
relationship: part_of IEV:0002339 ! TGF beta signaling pathway (through TAK1)

[Term]
id: IEV:0001809
name: Phosphorylation of NLK1 by TAK1
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001807 ! TCF phosphorylation signaling

[Term]
id: IEV:0001810
name: Phosphorylation of TCF by NLK1
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001807 ! TCF phosphorylation signaling

[Term]
id: IEV:0001811
name: Negative feedback regulation of Wnt signaling pathway
is_a: IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001812
name: Binding of beta catenin and beta-TrCP
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001813 ! Negative feedback regulation of Wnt signaling pathway (through beta-TrCP)

[Term]
id: IEV:0001813
name: Negative feedback regulation of Wnt signaling pathway (through beta-TrCP)
is_a: IEV:0001811 ! Negative feedback regulation of Wnt signaling pathway

[Term]
id: IEV:0001814
name: Binding of SFRP and Wnt receptor
xref_analog: PubMed:15549094
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001815
name: Binding of Wnt and LRP5/6
xref_analog: PubMed:15549094
is_a: IEV:0001816 ! Binding of Wnt and Wnt receptor

[Term]
id: IEV:0001816
name: Binding of Wnt and Wnt receptor
xref_analog: PubMed:15549094
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001817
name: Binding of WIF and Wnt receptor
xref_analog: PubMed:15549094
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001818
name: Binding of Dkk and Wnt receptor
xref_analog: PubMed:15549094
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001819
name: Complex formation of beta catenin, TCF/LEF, Legs, Pygonus, etc.
xref_analog: PubMed:15549094
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001820
name: Circulation
def: "The flow of blood through the body of an animal, enabling the transport of O2 and nutrients to the tissues and the removal of waste products." [GO:0008015]
xref_analog: GO:0008015
is_a: IEV:0001327 ! Multicellular organismal process

[Term]
id: IEV:0001821
name: Regulation of blood vessel size
def: "Any process that modulates the size of blood vessels." [GO:0050880]
xref_analog: GO:0050880
relationship: part_of IEV:0001820 ! Circulation

[Term]
id: IEV:0001822
name: Vasoconstriction
def: "A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure." [GO:0042310]
related_synonym: "Negative regulation of blood vessel size" [GO:0042310]
xref_analog: GO:0042310
is_a: IEV:0001821 ! Regulation of blood vessel size

[Term]
id: IEV:0001823
name: Muscle cell differentiation
def: "The process whereby a relatively unspecialized cell acquires specialized features of a muscle cell." [GO:0042692]
xref_analog: GO:0042692
is_a: IEV:0000002 ! Cell differentiation

[Term]
id: IEV:0001824
name: Smooth muscle cell differentiation
def: "The process whereby a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [GO:0051145]
related_synonym: "nonstriated muscle cell differentiation" [GO:0051145]
xref_analog: GO:0051145
is_a: IEV:0001823 ! Muscle cell differentiation

[Term]
id: IEV:0001826
name: Sumoylation of STAT1/3/4 by PIAS1/3
xref_analog: PubMed:14607831
is_a: IEV:0001765 ! Sumoylation of STAT1 by PIAS

[Term]
id: IEV:0001827
name: Sumoylation of STAT1/3/4 by PIASx/y
xref_analog: PubMed:14607831
is_a: IEV:0001765 ! Sumoylation of STAT1 by PIAS
is_a: IEV:0001829 ! SUMOylation in nucleus

[Term]
id: IEV:0001828
name: SUMOylation in cytosol and/or nucleus
is_a: IEV:0000118 ! SUMOylation

[Term]
id: IEV:0001829
name: SUMOylation in nucleus
is_a: IEV:0000118 ! SUMOylation

[Term]
id: IEV:0001830
name: Negative regulation of transcription in JAK STAT pathway by (STAT sumoylation by PIAS)
is_a: IEV:0000148 ! Negative regulation of translation by PIAS
is_a: IEV:0000150 ! Negative regulation of JAK STAT pathway

[Term]
id: IEV:0001831
name: Sumoylation of trans-activator by PIAS
xref_analog: PubMed:15021887
is_a: IEV:0001829 ! SUMOylation in nucleus
relationship: part_of IEV:0000148 ! Negative regulation of translation by PIAS

[Term]
id: IEV:0001832
name: Binding of trans-activator and co-repressor
xref_analog: PubMed:15021887
is_a: IEV:0000015 ! Binding in nucleus
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000148 ! Negative regulation of translation by PIAS

[Term]
id: IEV:0001833
name: Regulation of transcription
def: "Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GO:0045449]
xref_analog: GO:0045449
relationship: part_of IEV:0000183 ! Transcription
relationship: part_of IEV:0001835 ! Regulation of gene expression

[Term]
id: IEV:0001834
name: Positive regulation of transcription
is_a: IEV:0001833 ! Regulation of transcription
relationship: part_of IEV:0001836 ! Positive regulation of gene expression

[Term]
id: IEV:0001835
name: Regulation of gene expression
def: "Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence." [GO:0040029]
xref_analog: GO:0040029
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000182 ! Gene expression

[Term]
id: IEV:0001836
name: Positive regulation of gene expression
def: "Any epigenetic process that activates or increases the rate of gene expression." [GO:0045815]
xref_analog: GO:0045815
is_a: IEV:0001669 ! Positive regulation pathway
is_a: IEV:0001835 ! Regulation of gene expression

[Term]
id: IEV:0001837
name: Negative regulation of gene expression
def: "Any epigenetic process that stops, prevents or reduces the rate of gene expression." [GO:0045814]
xref_analog: GO:0045814
is_a: IEV:0001670 ! Negative regulation pathway
is_a: IEV:0001835 ! Regulation of gene expression

[Term]
id: IEV:0001838
name: Negative regulation of transcription
is_a: IEV:0001833 ! Regulation of transcription
relationship: part_of IEV:0001837 ! Negative regulation of gene expression

[Term]
id: IEV:0001839
name: Negative regulation of translation
relationship: part_of IEV:0001837 ! Negative regulation of gene expression
relationship: part_of IEV:0001841 ! Regulation of translation

[Term]
id: IEV:0001840
name: Positive regulation of translation
relationship: part_of IEV:0001836 ! Positive regulation of gene expression
relationship: part_of IEV:0001841 ! Regulation of translation

[Term]
id: IEV:0001841
name: Regulation of translation
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GO:0006417]
xref_analog: GO:0006417
relationship: part_of IEV:0000219 ! Translation
relationship: part_of IEV:0001835 ! Regulation of gene expression

[Term]
id: IEV:0001842
name: Signal transduction pathway
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell." [GO:0007165]
xref_analog: GO:0007165
is_a: IEV:0000001 ! Pathway

[Term]
id: IEV:0001843
name: Negative regulation of (Phosphorylation of cytokine receptor) in JAK STAT pathway
is_a: IEV:0000150 ! Negative regulation of JAK STAT pathway

[Term]
id: IEV:0001844
name: Negative regulation of (Phosphorylation of JAK) in JAK STAT pathway
xref_analog: PubMed:14607831
is_a: IEV:0000150 ! Negative regulation of JAK STAT pathway

[Term]
id: IEV:0001845
name: Negative regulation of (Phosphorylation of STAT) in JAK STAT pathway
is_a: IEV:0000150 ! Negative regulation of JAK STAT pathway

[Term]
id: IEV:0001846
name: Negative regulation of (nuclear import of R-smad:smad4) in TGF beta super family signaling pathway
is_a: IEV:0000880 ! Negative regulation of TGF beta super family signaling pathway

[Term]
id: IEV:0001847
name: Positive regulation of (transcription by R-smad:smad4 ) in TGF beta super family signaling pathway by (smad4 sumoylation by PIAS1)
is_a: IEV:0002190 ! Positive regulation of (transcription by R-smad:smad4 ) in TGF beta super family signaling pathway

[Term]
id: IEV:0001848
name: Negative regulation of (phosphorylation of AKT(PKB)) in AKT(PKB) activation signaling
is_a: IEV:0001486 ! Negative regulation of AKT(PKB) activation signaling

[Term]
id: IEV:0001849
name: Negative regulation of (dephosphorylation of AKT(PKB)) in negative regulation of AKT(PKB)-Bad signaling
is_obsolete: true

[Term]
id: IEV:0001850
name: Regulation of AKT(PKB)-Bad signaling
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000166 ! AKT(PKB)-Bad signaling

[Term]
id: IEV:0001851
name: Negative regulation of AKT(PKB)-Bad signaling
is_a: IEV:0001670 ! Negative regulation pathway
is_a: IEV:0001850 ! Regulation of AKT(PKB)-Bad signaling

[Term]
id: IEV:0001852
name: Positive regulation of AKT(PKB)-Bad signaling
is_a: IEV:0001669 ! Positive regulation pathway
is_a: IEV:0001850 ! Regulation of AKT(PKB)-Bad signaling

[Term]
id: IEV:0001853
name: Positive regulation of (phosphorylation of Bad) in AKT(PKB)-Bad signaling
is_obsolete: true

[Term]
id: IEV:0001854
name: Binding of TGF beta and TGF-beta receptor II
is_a: IEV:0000154 ! Binding of TGF beta and TGF beta superfamily receptor
relationship: part_of IEV:0002339 ! TGF beta signaling pathway (through TAK1)

[Term]
id: IEV:0001855
name: Binding of TGF beta:TGF beta receptor II and TGF beta receptor I
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0002339 ! TGF beta signaling pathway (through TAK1)

[Term]
id: IEV:0001856
name: Binding of BMP2 and BMP receptor I
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0002338 ! BMP2 signaling pathway(through TAK1)

[Term]
id: IEV:0001857
name: Negative regulation of (phosphorylation of Bad) in AKT(PKB)-Bad signaling
is_obsolete: true

[Term]
id: IEV:0001858
name: Negative regulation of (phosphorylation of PIP2) in AKT(PKB) activation signaling
is_a: IEV:0001486 ! Negative regulation of AKT(PKB) activation signaling

[Term]
id: IEV:0001859
name: Regulation of (negative regulation of AKT(PKB) activation signaling)
is_a: IEV:0001486 ! Negative regulation of AKT(PKB) activation signaling

[Term]
id: IEV:0001860
name: Negative regulation of (negative regulation of AKT(PKB) activation signaling)
is_a: IEV:0001859 ! Regulation of (negative regulation of AKT(PKB) activation signaling)

[Term]
id: IEV:0001861
name: Negative regulation of (dephosphorylation of AKT(PKB) in negative regulation of AKT(PKB) activation signaling)
is_a: IEV:0001860 ! Negative regulation of (negative regulation of AKT(PKB) activation signaling)

[Term]
id: IEV:0001862
name: Positive regulation of (phosphorylation of AKT(PKB) in AKT(PKB) activation signaling
is_a: IEV:0001487 ! Positive regulation of AKT(PKB) activation signaling

[Term]
id: IEV:0001863
name: Protein nuclear import/export signaling
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0001864
name: HDAC nuclear import/export signaling
is_a: IEV:0001863 ! Protein nuclear import/export signaling

[Term]
id: IEV:0001865
name: HDAC nuclear import signaling
is_a: IEV:0001875 ! Negative regulation of transcription in endothelin signaling by histone acetylation
relationship: part_of IEV:0001864 ! HDAC nuclear import/export signaling

[Term]
id: IEV:0001866
name: HDAC nuclear export signaling
relationship: part_of IEV:0001693 ! Endothelin receptor signaling
relationship: part_of IEV:0001864 ! HDAC nuclear import/export signaling

[Term]
id: IEV:0001867
name: Regulation of HDAC nuclear export signaling
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0001866 ! HDAC nuclear export signaling

[Term]
id: IEV:0001868
name: Positive regulation of HDAC nuclear export signaling
is_a: IEV:0001669 ! Positive regulation pathway
is_a: IEV:0001867 ! Regulation of HDAC nuclear export signaling

[Term]
id: IEV:0001869
name: Negative regulation of HDAC nuclear export signaling
is_a: IEV:0001670 ! Negative regulation pathway
is_a: IEV:0001867 ! Regulation of HDAC nuclear export signaling

[Term]
id: IEV:0001870
name: Regulation of HDAC nuclear import signaling
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0001865 ! HDAC nuclear import signaling

[Term]
id: IEV:0001871
name: Negative regulation of HDAC nuclear import signaling
is_a: IEV:0001670 ! Negative regulation pathway
is_a: IEV:0001870 ! Regulation of HDAC nuclear import signaling

[Term]
id: IEV:0001872
name: Positive regulation of HDAC nuclear import signaling
is_a: IEV:0001669 ! Positive regulation pathway
is_a: IEV:0001870 ! Regulation of HDAC nuclear import signaling

[Term]
id: IEV:0001873
name: Dissociation of HDAC5/7 and MEF2
is_a: IEV:0001046 ! Dissociation in the inner space of the nuclear
relationship: part_of IEV:0001866 ! HDAC nuclear export signaling

[Term]
id: IEV:0001874
name: Transcription by MEF2
is_a: IEV:0000183 ! Transcription
relationship: part_of IEV:0001693 ! Endothelin receptor signaling

[Term]
id: IEV:0001875
name: Negative regulation of transcription in endothelin signaling by histone acetylation
is_a: IEV:0001696 ! Negative regulation of endothelin receptor signaling

[Term]
id: IEV:0001876
name: Deacetylation of histone by HDAC5/7
xref_analog: PubMed:11509672
xref_analog: PubMed:11585834
is_a: IEV:0001683 ! Deacetylation in nucleus
relationship: part_of IEV:0001865 ! HDAC nuclear import signaling

[Term]
id: IEV:0001877
name: Binding of HDAC5 and importin alpha
xref_analog: PubMed:11509672
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001865 ! HDAC nuclear import signaling

[Term]
id: IEV:0001878
name: Heparan sulfate biosynthesis
xref_analog: KEGG:map00534
relationship: part_of IEV:0001558 ! Glycan Biosynthesis and Metabolism

[Term]
id: IEV:0001879
name: Deacetylation of histone by HDAC5
xref_analog: PubMed:11509672
is_a: IEV:0001876 ! Deacetylation of histone by HDAC5/7

[Term]
id: IEV:0001880
name: Deacetylation of histone by HDAC7
xref_analog: PubMed:11585834
is_a: IEV:0001876 ! Deacetylation of histone by HDAC5/7

[Term]
id: IEV:0001881
name: Tryptophan biosynthesis
def: "The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [GO:0000162]
related_synonym: "tryptophan anabolism" []
related_synonym: "tryptophan biosynthetic process" []
related_synonym: "tryptophan formation" []
related_synonym: "tryptophan synthesis" []
xref_analog: GO:0000162
xref_analog: KEGG:map00400
is_a: IEV:0001462 ! Tryptophan metabolism

[Term]
id: IEV:0001882
name: Nuclear import of HDAC5
xref_analog: PubMed:11509672
is_a: IEV:0001705 ! Nuclear import of HDAC5/7

[Term]
id: IEV:0001883
name: Nuclear import of HDAC7
xref_analog: PubMed:11585834
is_a: IEV:0001705 ! Nuclear import of HDAC5/7

[Term]
id: IEV:0001884
name: Dissociation of HDAC7 and MEF2
is_a: IEV:0001873 ! Dissociation of HDAC5/7 and MEF2

[Term]
id: IEV:0001885
name: Dissociation of HDAC5 and MEF2
is_a: IEV:0001873 ! Dissociation of HDAC5/7 and MEF2

[Term]
id: IEV:0001886
name: Molecular interaction
is_a: IEV:0000071 ! Molecular event

[Term]
id: IEV:0001887
name: Phosphorylation of Fyn by Csk and inactive conformational change
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0001596 ! Phosphorylation of Fyn by non-receptor kinase and inactive conformational change

[Term]
id: IEV:0001888
name: Negative regulation of (Autophosphorylation of Fyn) in Fyn activation signaling
is_a: IEV:0001629 ! Negative regulation of Fyn activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001889
name: Negative regulation of (dephosphorylation of Fyn) in Fyn activation signaling
is_a: IEV:0001629 ! Negative regulation of Fyn activation signaling (through autophosphorylation and PTP)

[Term]
id: IEV:0001890
name: Lck inactivation signaling (through Csk)
is_a: IEV:0001632 ! Negative regulation of (dephosphorylation of Lck) Lck activation signaling (autophosphorylation and PTP)

[Term]
id: IEV:0001891
name: Fyn inactivation signaling (through Csk)
is_a: IEV:0001634 ! Fyn inactivation signaling
is_a: IEV:0001889 ! Negative regulation of (dephosphorylation of Fyn) in Fyn activation signaling

[Term]
id: IEV:0001892
name: Src inactivation signaling (through PTP)
is_a: IEV:0001642 ! Src inactivation signaling

[Term]
id: IEV:0001893
name: Src inactivation signaling (through non-receptor kinase)
is_a: IEV:0001642 ! Src inactivation signaling

[Term]
id: IEV:0001894
name: Negative regulation of (phosphorylation of Lck) Lck activation signaling (autophosphorylation and PTP)
is_a: IEV:0001896 ! Negative regulation of Lck activation signaling (autophosphorylation and PTP)

[Term]
id: IEV:0001895
name: Phosphorylation of Lck by Csk and inactive conformational change
is_a: IEV:0000025 ! Phosphorylation in cytosol
is_a: IEV:0001591 ! Phosphorylation of Lck by non-receptor kinase and inactive conformational change

[Term]
id: IEV:0001896
name: Negative regulation of Lck activation signaling (autophosphorylation and PTP)
is_a: IEV:0001631 ! Regulation of Lck activation signaling (autophosphorylation and PTP)

[Term]
id: IEV:0001897
name: Binding of  phosphatidylserine and PKC and active conformational change of PKC
xref_analog: PubMed:7499357
is_a: IEV:0000014 ! Binding in plasma membrane
relationship: part_of IEV:0000779 ! PKC activation signaling

[Term]
id: IEV:0001898
name: Binding of phosphatidylserine and cPKC and active conformational change of PKC
xref_analog: PubMed:7499357
is_a: IEV:0001897 ! Binding of  phosphatidylserine and PKC and active conformational change of PKC
relationship: part_of IEV:0001392 ! cPKC activation signaling

[Term]
id: IEV:0001899
name: Binding of phosphatidylserine and PKC theta and active conformational change of PKC
xref_analog: PubMed:7499357
is_a: IEV:0001897 ! Binding of  phosphatidylserine and PKC and active conformational change of PKC
relationship: part_of IEV:0001391 ! PKC theta activation signaling

[Term]
id: IEV:0001900
name: Regulation of cPKC activation signaling
is_a: IEV:0001909 ! Regulation of PKC activation signaling
relationship: part_of IEV:0001392 ! cPKC activation signaling

[Term]
id: IEV:0001901
name: Negative regulation of cPKC activation signaling
is_a: IEV:0001900 ! Regulation of cPKC activation signaling
is_a: IEV:0001911 ! Negative regulation of PKC activation signaling

[Term]
id: IEV:0001902
name: Positive regulation of cPKC activation signaling
is_a: IEV:0001900 ! Regulation of cPKC activation signaling
is_a: IEV:0001910 ! Positive regulation of PKC activation signaling

[Term]
id: IEV:0001903
name: Negative regulation of (binding of calcium ion and cPKC) in cPKC activation signaling
is_a: IEV:0001901 ! Negative regulation of cPKC activation signaling

[Term]
id: IEV:0001904
name: Negative regulation of (binding of DAG and cPKC) in cPKC activation signaling
is_a: IEV:0001901 ! Negative regulation of cPKC activation signaling

[Term]
id: IEV:0001905
name: Negative regulation of (binding of phosphatidylserine and cPKC) in cPKC activation signaling
is_a: IEV:0001901 ! Negative regulation of cPKC activation signaling

[Term]
id: IEV:0001906
name: Dissociation of calcium ion and cPKC
relationship: part_of IEV:0001903 ! Negative regulation of (binding of calcium ion and cPKC) in cPKC activation signaling

[Term]
id: IEV:0001907
name: Dissociation of DAG and cPKC
relationship: part_of IEV:0001904 ! Negative regulation of (binding of DAG and cPKC) in cPKC activation signaling

[Term]
id: IEV:0001908
name: Dissociation of phosphatidylserine and cPKC
relationship: part_of IEV:0001905 ! Negative regulation of (binding of phosphatidylserine and cPKC) in cPKC activation signaling

[Term]
id: IEV:0001909
name: Regulation of PKC activation signaling
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000779 ! PKC activation signaling

[Term]
id: IEV:0001910
name: Positive regulation of PKC activation signaling
is_a: IEV:0001669 ! Positive regulation pathway
is_a: IEV:0001909 ! Regulation of PKC activation signaling

[Term]
id: IEV:0001911
name: Negative regulation of PKC activation signaling
is_a: IEV:0001670 ! Negative regulation pathway
is_a: IEV:0001909 ! Regulation of PKC activation signaling

[Term]
id: IEV:0001912
name: Regulation of PKC theta activation signaling
is_a: IEV:0001909 ! Regulation of PKC activation signaling
relationship: part_of IEV:0001391 ! PKC theta activation signaling

[Term]
id: IEV:0001913
name: Negative regulation of PKC theta activation signaling
is_a: IEV:0001911 ! Negative regulation of PKC activation signaling
is_a: IEV:0001912 ! Regulation of PKC theta activation signaling

[Term]
id: IEV:0001914
name: Positive regulation of PKC theta activation signaling
is_a: IEV:0001910 ! Positive regulation of PKC activation signaling
is_a: IEV:0001912 ! Regulation of PKC theta activation signaling

[Term]
id: IEV:0001915
name: Negative regulation of (binding of DAG and PKC theta) in PKC theta activation signaling
is_a: IEV:0001913 ! Negative regulation of PKC theta activation signaling

[Term]
id: IEV:0001916
name: Negative regulation of (binding of phosphatidylserine and PKC theta) in PKC theta activation signaling
is_a: IEV:0001913 ! Negative regulation of PKC theta activation signaling

[Term]
id: IEV:0001917
name: Dissociation of DAG and PKC theta
relationship: part_of IEV:0001915 ! Negative regulation of (binding of DAG and PKC theta) in PKC theta activation signaling

[Term]
id: IEV:0001918
name: Dissociation of phosphatidylserine and PKC theta
relationship: part_of IEV:0001916 ! Negative regulation of (binding of phosphatidylserine and PKC theta) in PKC theta activation signaling

[Term]
id: IEV:0001919
name: Negative regulation of (binding of calcium ion and PKC) in PKC activation signaling
is_a: IEV:0001911 ! Negative regulation of PKC activation signaling

[Term]
id: IEV:0001920
name: Negative regulation of (binding of DAG and PKC) in PKC activation signaling
is_a: IEV:0001911 ! Negative regulation of PKC activation signaling

[Term]
id: IEV:0001921
name: Negative regulation of (binding of phosphatidylserine and PKC) in PKC activation signaling
is_a: IEV:0001911 ! Negative regulation of PKC activation signaling

[Term]
id: IEV:0001922
name: Dissociation of calcium ion and PKC
relationship: part_of IEV:0001919 ! Negative regulation of (binding of calcium ion and PKC) in PKC activation signaling

[Term]
id: IEV:0001923
name: Dissociation of DAG and PKC
relationship: part_of IEV:0001920 ! Negative regulation of (binding of DAG and PKC) in PKC activation signaling

[Term]
id: IEV:0001924
name: Dissociation of phosphatidylserine and PKC
relationship: part_of IEV:0001921 ! Negative regulation of (binding of phosphatidylserine and PKC) in PKC activation signaling

[Term]
id: IEV:0001925
name: Regulation of PKA activation signaling
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000780 ! PKA activation signaling

[Term]
id: IEV:0001926
name: Negative regulation of PKA activation signaling
is_a: IEV:0001670 ! Negative regulation pathway
is_a: IEV:0001925 ! Regulation of PKA activation signaling

[Term]
id: IEV:0001927
name: Positive regulation of PKA activation signaling
is_a: IEV:0001669 ! Positive regulation pathway
is_a: IEV:0001925 ! Regulation of PKA activation signaling

[Term]
id: IEV:0001928
name: Negative feedback regulation of p53 degradation signaling
is_obsolete: true

[Term]
id: IEV:0001929
name: Binding of Mdm2 and p14ARF
xref_analog: PubMed:15021897
is_a: IEV:0001934 ! Binding of Mdm2 and ARF

[Term]
id: IEV:0001932
name: Ubiquitination of p53 by ubiquitin ligase
xref_analog: PubMed:15021897
is_a: IEV:0000871 ! Ubiquitination in nucleus
relationship: part_of IEV:0000868 ! p53 degradation signaling

[Term]
id: IEV:0001933
name: Binding of Mdm2 and MdmX
xref_analog: PubMed:12860999
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001124 ! Positive regulation of p53 degradation signaling

[Term]
id: IEV:0001934
name: Binding of Mdm2 and ARF
xref_analog: PubMed:12860999
xref_analog: PubMed:15021897
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001123 ! Negative regulation of p53 degradation signaling

[Term]
id: IEV:0001936
name: Palmitoylation of Wnt by Porcupine
xref_analog: PubMed:15166250
xref_analog: PubMed:15473860
xref_analog: PubMed:8985181
is_a: IEV:0001937 ! Palmitoylation in ER
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0002269 ! Wnt signaling pathway (Drosophila)

[Term]
id: IEV:0001937
name: Palmitoylation in ER
is_a: IEV:0000918 ! Palmitoylation

[Term]
id: IEV:0001938
name: Translocation of Wnt from ER to extracellular space
xref_analog: PubMed:15473860
is_a: IEV:0001939 ! Translocation from ER to extracellular space
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0002269 ! Wnt signaling pathway (Drosophila)

[Term]
id: IEV:0001939
name: Translocation from ER to extracellular space
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0001940
name: Translocation of Arrow/LRP5/6 from ER to plasma membrane
xref_analog: PubMed:12581524
xref_analog: PubMed:15473860
is_a: IEV:0001941 ! Translocation from ER to plasma membrane
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0002268 ! Wnt signaling pathway (Mammalia)
relationship: part_of IEV:0002269 ! Wnt signaling pathway (Drosophila)

[Term]
id: IEV:0001941
name: Translocation from ER to plasma membrane
is_a: IEV:0000009 ! Translocation

[Term]
id: IEV:0001942
name: Translocation from cytosol to plasma membrane
alt_id: IEV:0002197
related_synonym: "Translocation from cytosol to plasma membrane" []
is_a: IEV:0000009 ! Translocation
relationship: part_of IEV:0001167 ! Translocation from Golgi to plasma membrane

[Term]
id: IEV:0001943
name: Translocation from ER to cytosol
alt_id: IEV:0000275
related_synonym: "Translocation from the ER to the cytosol" []
is_a: IEV:0000009 ! Translocation
relationship: part_of IEV:0002612 ! Translocation from ER to Golgi

[Term]
id: IEV:0001944
name: Translocation of LRP6 from ER to plasma membrane
is_a: IEV:0001941 ! Translocation from ER to plasma membrane
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001945
name: Translocation of Arrow/LRP5/6 from ER to cytosol
is_a: IEV:0001943 ! Translocation from ER to cytosol

[Term]
id: IEV:0001946
name: Translocation of Arrow/LRP5/6 from cytosol to plasma membrane
is_a: IEV:0001942 ! Translocation from cytosol to plasma membrane

[Term]
id: IEV:0001947
name: Translocation of LRP6 from cytosol to plasma membrane
is_a: IEV:0001942 ! Translocation from cytosol to plasma membrane

[Term]
id: IEV:0001948
name: Translocation of LRP6 from ER to cytosol
is_a: IEV:0001943 ! Translocation from ER to cytosol

[Term]
id: IEV:0001949
name: Binding of Wnt, Frizzled and Arrow/LRP5/6
xref_analog: PubMed:11029006
xref_analog: PubMed:11029007
xref_analog: PubMed:12205098
xref_analog: PubMed:15473860
xref_analog: PubMed:8717036
is_a: IEV:0000016 ! Binding in extracellular
is_a: IEV:0001816 ! Binding of Wnt and Wnt receptor
relationship: part_of IEV:0002267 ! Wnt signaling pathway (Xenopus)
relationship: part_of IEV:0002268 ! Wnt signaling pathway (Mammalia)
relationship: part_of IEV:0002269 ! Wnt signaling pathway (Drosophila)

[Term]
id: IEV:0001950
name: Phosphorylation of Arrow/LRP5/6
xref_analog: PubMed:11029007
xref_analog: PubMed:14731402
xref_analog: PubMed:15473860
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0002267 ! Wnt signaling pathway (Xenopus)
relationship: part_of IEV:0002268 ! Wnt signaling pathway (Mammalia)
relationship: part_of IEV:0002269 ! Wnt signaling pathway (Drosophila)

[Term]
id: IEV:0001951
name: Binding of Arrow/LRP5/6 and Axin
xref_analog: PubMed:11336703
xref_analog: PubMed:1236921
xref_analog: PubMed:14731402
xref_analog: PubMed:15473860
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0002267 ! Wnt signaling pathway (Xenopus)
relationship: part_of IEV:0002268 ! Wnt signaling pathway (Mammalia)
relationship: part_of IEV:0002269 ! Wnt signaling pathway (Drosophila)

[Term]
id: IEV:0001952
name: Binding of Dsh and Axin
xref_analog: PubMed:10688669
xref_analog: PubMed:15473860
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0002267 ! Wnt signaling pathway (Xenopus)

[Term]
id: IEV:0001953
name: Binding of Dsh and GBP/Frat and GSK-3
xref_analog: PubMed:10428961
xref_analog: PubMed:10684251
xref_analog: PubMed:10882137
xref_analog: PubMed:15473860
xref_analog: PubMed:9635432
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway
relationship: part_of IEV:0002267 ! Wnt signaling pathway (Xenopus)
relationship: part_of IEV:0002268 ! Wnt signaling pathway (Mammalia)
relationship: part_of IEV:0002269 ! Wnt signaling pathway (Drosophila)

[Term]
id: IEV:0001954
name: Complex formation of Axin, APC, GSK-3, Beta catenin and PP2A
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001955
name: Dephosphorylation of beta-catenin by PP2A
is_a: IEV:0000022 ! Dephosphorylation in cytosol
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001956
name: Binding of Pygopus, Legless and beta-catenin:TCF complex
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001957
name: Binding of CBP and beta-catenin
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001958
name: Binding of Brg1 and beta-catenin:TCF complex
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0000027 ! Wnt signaling pathway

[Term]
id: IEV:0001959
name: Binding of Wnt and WIF
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001960
name: Binding of Wnt and SFRP
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001961
name: Binding of Dkk, Arrow/LRP5/6 and Kremen
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001962
name: Binding of Dkk1, LRP6 and Kremen2
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001963
name: Binding of Dkk2, Arrow/LRP5/6 and Kremen2
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001964
name: Binding of Wise and Arrow/LRP5/6
is_a: IEV:0000016 ! Binding in extracellular
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001965
name: Internalization of Arrow/LRP5/6
is_a: IEV:0001505 ! Receptor internalization
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001966
name: Internalization of LRP6
is_a: IEV:0001505 ! Receptor internalization
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001967
name: Complex formation of Axin, APC, GSK-3 and Beta catenin
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001968
name: Complex formation of Axin, APC, GSK-3, CK1a and Beta catenin
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001969
name: Phosphorylation of beta-catenin by CK1a
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001970
name: Phosphorylation of beta-catenin by GSK-3
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001971
name: Ubiquitination of beta-catenin by SCF ubiquitin ligase complex
alt_id: IEV:0001740
related_synonym: "Ubiquitination of beta catenin" []
is_a: IEV:0000026 ! Ubiquitination in cytosol
relationship: part_of IEV:0001739 ! Beta catenin degradation signaling

[Term]
id: IEV:0001972
name: Binding of Chibby and beta-catenin
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001973
name: Binding of ICAT and beta-catenin
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001974
name: Phosphorylation of TCF by NLK
is_a: IEV:0001082 ! Phosphorylation in the inner space of the nuclear
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001975
name: Binding of Groucho and TCF
is_a: IEV:0000015 ! Binding in nucleus
is_a: IEV:0001041 ! Binding in inner space of nucleus
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001976
name: Nuclear export of TCF
is_a: IEV:0000019 ! Nuclear export
relationship: part_of IEV:0001676 ! Negative regulation of Wnt signaling pathway

[Term]
id: IEV:0001977
name: Binding of IRS and PI3K
xref_analog: PubMed:11282018
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000487 ! Insulin receptor signaling pathway
relationship: part_of IEV:0001979 ! PI3K activation signaling (through IRS)

[Term]
id: IEV:0001978
name: PI3K activation signaling (through Estrogen receptor)
is_a: IEV:0001227 ! PI3K activation signaling

[Term]
id: IEV:0001979
name: PI3K activation signaling (through IRS)
is_a: IEV:0001227 ! PI3K activation signaling

[Term]
id: IEV:0001980
name: Dissociation of IRAK1_p and TRAF6
xref_analog: PubMed:12620219
is_a: IEV:0000023 ! Dissociation in cytosol
relationship: part_of IEV:0000063 ! IL1 signaling (through IKK-NF-kappaB cascade)
relationship: part_of IEV:0000224 ! IL-1 signaling (through JNK cascade)
relationship: part_of IEV:0000232 ! IL-1 signaling (through p38 cascade)

[Term]
id: IEV:0001981
name: Binding of G alpha and G beta:G gamma
xref_analog: PubMed:14734786
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0001982
name: Binding of G alpha s-GDP and G beta:G gamma
xref_analog: PubMed:14734786
is_a: IEV:0001981 ! Binding of G alpha and G beta:G gamma
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)
relationship: part_of IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
relationship: part_of IEV:0002637 ! Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)

[Term]
id: IEV:0001983
name: Binding of GPCR and G alpha
xref_analog: PubMed:14734786
is_a: IEV:0000013 ! Binding in cytosol
relationship: part_of IEV:0002012 ! G alpha GDP-GTP exchange signaling

[Term]
id: IEV:0001984
name: Binding of GPCR and G alpha s
xref_analog: PubMed:14734786
is_a: IEV:0001983 ! Binding of GPCR and G alpha
relationship: part_of IEV:0002003 ! G alpha s GDP-GTP exchange signaling

[Term]
id: IEV:0001985
name: Binding of G beta gamma and PI3K gamma
comment: Free Gbetagamma can directly bind the regulatory p101 of PI3K gamma, leading to PI3K activation.
xref_analog: PubMed:14734786
relationship: part_of IEV:0001987 ! PI3K gamma activation singlaing

[Term]
id: IEV:0001987
name: PI3K gamma activation singlaing
is_a: IEV:0001227 ! PI3K activation signaling

[Term]
id: IEV:0001988
name: cAMP mediated signaling
def: "A series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GO:0019933]
related_synonym: "3',5' cAMP-mediated signaling" []
related_synonym: "3',5'-cAMP-mediated signaling" []
related_synonym: "adenosine 3',5'-cyclophosphate-mediated signaling" []
related_synonym: "cAMP signaling" []
related_synonym: "cAMP-mediated signaling" []
related_synonym: "cyclic AMP-mediated signaling" []
xref_analog: GO:0019933
is_a: IEV:0001842 ! Signal transduction pathway

[Term]
id: IEV:0001989
name: Epac activation signaling
comment: Epac = Rap guanine nucleotide exchange factor by cAMP
is_a: IEV:0001988 ! cAMP mediated signaling

[Term]
id: IEV:0001990
name: Cyclic nucleotide-gated cannel activation signaling
is_a: IEV:0001988 ! cAMP mediated signaling

[Term]
id: IEV:0001991
name: Phosphorylation of PI3K by JAK3_p
is_a: IEV:0000025 ! Phosphorylation in cytosol
relationship: part_of IEV:0000140 ! IL7 signaling (JAK1, JAK3, STAT5)

[Term]
id: IEV:0001992
name: Binding of G alpha s-GTP and effector
is_a: IEV:0000666 ! Binding of G alpha-GTP and effector
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)

[Term]
id: IEV:0001993
name: Binding of G alpha s-GTP and Src family tyrosine kinase
xref_analog: PubMed:14734786
is_a: IEV:0001992 ! Binding of G alpha s-GTP and effector

[Term]
id: IEV:0001994
name: Binding of G beta gamma and GRK2/3
xref_analog: PubMed:14734786
is_obsolete: true

[Term]
id: IEV:0001995
name: Binding of G beta gamma and calcium ion channel
is_obsolete: true

[Term]
id: IEV:0001996
name: Binding of G beta gamma and sodium ion channel
xref_analog: PubMed:14734786
is_obsolete: true

[Term]
id: IEV:0001997
name: Binding of G alpha i-GTP and effector
is_a: IEV:0000666 ! Binding of G alpha-GTP and effector
relationship: part_of IEV:0000692 ! Heterotrimeric GPCR signaling pathway (through G alpha i)

[Term]
id: IEV:0001998
name: Binding of G alpha o-GTP and effector
is_a: IEV:0000666 ! Binding of G alpha-GTP and effector
is_a: IEV:0000773 ! Heterotrimeric GPCR signaling pathway (through melatonin, G alpha o and PLCbeta)

[Term]
id: IEV:0001999
name: Binding of G alpha i-GTP and PLC beta
xref_analog: PubMed:14734786
is_obsolete: true

[Term]
id: IEV:0002000
name: Binding of G alpha 11-GTP and PLC beta
xref_analog: PubMed:14734786
is_a: IEV:0002014 ! Binding of G alpha 11-GTP and effector

[Term]
id: IEV:0002001
name: Binding of G alpha 12/13-GTP and Rho GEF
xref_analog: PubMed:14734786
is_a: IEV:0002015 ! Binding of G alpha 12/13-GTP and PLC beta

[Term]
id: IEV:0002002
name: Negative regulation of (Binding of G alpha s-GTP and adenylate cyclase)
is_a: IEV:0000693 ! Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
is_a: IEV:0002006 ! Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)

[Term]
id: IEV:0002003
name: G alpha s GDP-GTP exchange signaling
related_synonym: "G alpha s activation signaling" []
is_a: IEV:0002012 ! G alpha GDP-GTP exchange signaling
relationship: part_of IEV:0000691 ! Heterotrimeric GPCR signaling pathway (through G alpha s)
relationship: part_of IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
relationship: part_of IEV:0002637 ! Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s)

[Term]
id: IEV:0002004
name: Negative regulation of (G alpha s GDP-GTP exchange signaling)
is_a: IEV:0000693 ! Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s)
is_a: IEV:0002006 ! Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)

[Term]
id: IEV:0002005
name: Regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
is_a: IEV:0000668 ! Regulation of heterotrimeric GPCR signaling pathway
relationship: part_of IEV:0000707 ! Heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)

[Term]
id: IEV:0002006
name: Negative regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
is_a: IEV:0000669 ! Negative regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0002005 ! Regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)

[Term]
id: IEV:0002007
name: Positive regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)
is_a: IEV:0000670 ! Positive regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0002005 ! Regulation of heterotrimeric GPCR signaling pathway (through G alpha s, cholera toxin, adenylate cyclase and cAMP)

[Term]
id: IEV:0002008
name: Regulation of G alpha s-GTP hydrolysis signaling
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0000702 ! G alpha s-GTP hydrolysis signaling

[Term]
id: IEV:0002009
name: Negative regulation of G alpha s-GTP hydrolysis signaling
is_a: IEV:0001670 ! Negative regulation pathway
is_a: IEV:0002008 ! Regulation of G alpha s-GTP hydrolysis signaling

[Term]
id: IEV:0002010
name: Positive regulation of G alpha s-GTP hydrolysis signaling
is_a: IEV:0001669 ! Positive regulation pathway
is_a: IEV:0002008 ! Regulation of G alpha s-GTP hydrolysis signaling

[Term]
id: IEV:0002011
name: Negative regulation of (Hydrolysis of GTP by G alpha s-GTP and RGS) (through G alpha s GDP-GTP exchange signaling)
is_a: IEV:0002009 ! Negative regulation of G alpha s-GTP hydrolysis signaling

[Term]
id: IEV:0002012
name: G alpha GDP-GTP exchange signaling
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0000661 ! GPCR signaling pathway

[Term]
id: IEV:0002013
name: Binding of G alpha t-GTP and effector
is_a: IEV:0000666 ! Binding of G alpha-GTP and effector

[Term]
id: IEV:0002014
name: Binding of G alpha 11-GTP and effector
is_a: IEV:0000666 ! Binding of G alpha-GTP and effector

[Term]
id: IEV:0002015
name: Binding of G alpha 12/13-GTP and PLC beta
is_a: IEV:0000666 ! Binding of G alpha-GTP and effector

[Term]
id: IEV:0002016
name: Binding of G alpha q-GTP and effector
is_a: IEV:0000666 ! Binding of G alpha-GTP and effector

[Term]
id: IEV:0002017
name: G alpha i GDP-GTP exchange signaling
is_a: IEV:0002012 ! G alpha GDP-GTP exchange signaling
relationship: part_of IEV:0000692 ! Heterotrimeric GPCR signaling pathway (through G alpha i)

[Term]
id: IEV:0002018
name: Binding of GPCR and G alpha i
xref_analog: PubMed:14734786
is_a: IEV:0001983 ! Binding of GPCR and G alpha
relationship: part_of IEV:0002017 ! G alpha i GDP-GTP exchange signaling

[Term]
id: IEV:0002019
name: Binding of G alpha i-GDP and G beta:G gamma
xref_analog: PubMed:14734786
is_a: IEV:0001981 ! Binding of G alpha and G beta:G gamma

[Term]
id: IEV:0002020
name: Negative regulation of (Binding of G alpha i-GTP and adenylate cyclase)
is_a: IEV:0002026 ! Negative regulation of heteromeric GPCR signaling pathway (through G alpha i)

[Term]
id: IEV:0002021
name: Adenylate cyclase activation signaling
def: "Any process that initiates the activity of the inactive enzyme adenylate cyclase." [GO:0007190]
related_synonym: "adenylate cyclase activation" []
xref_analog: GO:0007190
xref_analog: PubMed:14734786
is_a: IEV:0000458 ! Protein activation/inactivation signaling
relationship: part_of IEV:0000780 ! PKA activation signaling

[Term]
id: IEV:0002022
name: Adenylate cyclase inactivation signaling
xref_analog: PubMed:14734786
is_a: IEV:0000458 ! Protein activation/inactivation signaling

[Term]
id: IEV:0002023
name: Positive regulation of G alpha i-GTP hydrolysis signaling
is_a: IEV:0002024 ! Regulation of G alpha i-GTP hydrolysis signaling

[Term]
id: IEV:0002024
name: Regulation of G alpha i-GTP hydrolysis signaling
relationship: part_of IEV:0000701 ! G alpha i-GTP hydrolysis signaling

[Term]
id: IEV:0002025
name: Positive regulation of heteromeric GPCR signaling pathway (through G alpha i and pertussis toxin)
is_a: IEV:0000670 ! Positive regulation of heterotrimeric GPCR signaling pathway

[Term]
id: IEV:0002026
name: Negative regulation of heteromeric GPCR signaling pathway (through G alpha i)
is_a: IEV:0000669 ! Negative regulation of heterotrimeric GPCR signaling pathway
is_a: IEV:0000730 ! Regulation of heterotrimeric GPCR signaling pathway (through G alpha i)

[Term]
id: IEV:0002027
name: Negative regulation of (Binding of GPCR and G alpha i)
is_obsolete: true

[Term]
id: IEV:0002028
name: cAMP concentration elevation
is_a: IEV:0000771 ! Change in material concentration

[Term]
id: IEV:0002029
name: cAMP concentration decline
is_a: IEV:0000771 ! Change in material concentration

[Term]
id: IEV:0002030
name: Negative regulation of (Binding of GPCR ligand and GPCR)
is_a: IEV:0002026 ! Negative regulation of heteromeric GPCR signaling pathway (through G alpha i)

[Term]
id: IEV:0002031
name: G alpha q GDP-GTP exchange signaling
is_a: IEV:0002012 ! G alpha GDP-GTP exchange signaling
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
relationship: part_of IEV:0002633 ! Heterotrimeric GPCR signaling pathway (through Angiotensin and G alpha q)
relationship: part_of IEV:0002653 ! Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)

[Term]
id: IEV:0002032
name: Binding of G alpha q-GDP and G beta:G gamma
xref_analog: PubMed:14734786
is_a: IEV:0001981 ! Binding of G alpha and G beta:G gamma
relationship: part_of IEV:0000748 ! Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
relationship: part_of IEV:0002633 ! Heterotrimeric GPCR signaling pathway (through Angiotensin and G alpha q)
relationship: part_of IEV:0002653 ! Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)

[Term]
id: IEV:0002033
name: Negative regulation of G alpha i-GTP hydrolysis signaling
is_a: IEV:0002024 ! Regulation of G alpha i-GTP hydrolysis signaling

[Term]
id: IEV:0002034
name: Negative regulation of (Hydrolysis of GTP by G alpha i-GTP and RGS)
is_a: IEV:0002033 ! Negative regulation of G alpha i-GTP hydrolysis signaling

[Term]
id: IEV:0002035
name: Regulation of G alpha q-GTP hydrolysis signaling
relationship: part_of IEV:0000754 ! G alpha q-GTP hydrolysis signaling

[Term]
id: IEV:0002036
name: Negative regulation of G alpha q-GTP hydrolysis signaling
is_a: IEV:0002035 ! Regulation of G alpha q-GTP hydrolysis signaling

[Term]
id: IEV:0002037
name: Negative regulation of (Hydrolysis of GTP by G alpha q-GTP and RGS)
is_a: IEV:0002036 ! Negative regulation of G alpha q-GTP hydrolysis signaling

[Term]
id: IEV:0002038
name: Positive regulation of G alpha q-GTP hydrolysis signaling
is_a: IEV:0002035 ! Regulation of G alpha q-GTP hydrolysis signaling

[Term]
id: IEV:0002039
name: Regulation of G alpha t-GTP hydrolysis signaling
relationship: part_of IEV:0000735 ! G alpha t-GTP hydrolysis signaling

[Term]
id: IEV:0002040
name: Positive regulation of G alpha t-GTP hydrolysis signaling
is_a: IEV:0002039 ! Regulation of G alpha t-GTP hydrolysis signaling

[Term]
id: IEV:0002041
name: Negative regulation of G alpha t-GTP hydrolysis signaling
is_a: IEV:0002039 ! Regulation of G alpha t-GTP hydrolysis signaling

[Term]
id: IEV:0002042
name: Negative regulation of (Hydrolysis of GTP by G alpha t-GTP and RGS)
is_a: IEV:0002041 ! Negative regulation of G alpha t-GTP hydrolysis signaling

[Term]
id: IEV:0002043
name: G alpha t GDP-GTP exchange signaling
is_a: IEV:0002012 ! G alpha GDP-GTP exchange signaling

[Term]
id: IEV:0002044
name: Regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0000145 ! Regulation pathway
relationship: part_of IEV:0002012 ! G alpha GDP-GTP exchange signaling

[Term]
id: IEV:0002045
name: Regulation of G alpha s GDP-GTP exchange signaling
is_a: IEV:0002044 ! Regulation of G alpha GDP-GTP exchange signaling
relationship: part_of IEV:0002003 ! G alpha s GDP-GTP exchange signaling

[Term]
id: IEV:0002046
name: Negative regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0001670 ! Negative regulation pathway
is_a: IEV:0002044 ! Regulation of G alpha GDP-GTP exchange signaling

[Term]
id: IEV:0002047
name: Positive regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0001669 ! Positive regulation pathway
is_a: IEV:0002044 ! Regulation of G alpha GDP-GTP exchange signaling

[Term]
id: IEV:0002048
name: Regulation of G alpha i GDP-GTP exchange signaling
is_a: IEV:0002044 ! Regulation of G alpha GDP-GTP exchange signaling
relationship: part_of IEV:0002017 ! G alpha i GDP-GTP exchange signaling

[Term]
id: IEV:0002049
name: Regulation of G alpha q GDP-GTP exchange signaling
is_a: IEV:0002044 ! Regulation of G alpha GDP-GTP exchange signaling
relationship: part_of IEV:0002031 ! G alpha q GDP-GTP exchange signaling

[Term]
id: IEV:0002050
name: Regulation of G alpha t GDP-GTP exchange signaling
is_a: IEV:0002044 ! Regulation of G alpha GDP-GTP exchange signaling
relationship: part_of IEV:0002043 ! G alpha t GDP-GTP exchange signaling

[Term]
id: IEV:0002051
name: Negative regulation of G alpha i GDP-GTP exchange signaling
is_a: IEV:0002046 ! Negative regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0002048 ! Regulation of G alpha i GDP-GTP exchange signaling

[Term]
id: IEV:0002052
name: Negative regulation of G alpha q GDP-GTP exchange signaling
is_a: IEV:0002046 ! Negative regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0002049 ! Regulation of G alpha q GDP-GTP exchange signaling

[Term]
id: IEV:0002053
name: Negative regulation of G alpha s GDP-GTP exchange signaling
is_a: IEV:0002045 ! Regulation of G alpha s GDP-GTP exchange signaling
is_a: IEV:0002046 ! Negative regulation of G alpha GDP-GTP exchange signaling

[Term]
id: IEV:0002054
name: Negative regulation of G alpha t GDP-GTP exchange signaling
is_a: IEV:0002046 ! Negative regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0002050 ! Regulation of G alpha t GDP-GTP exchange signaling

[Term]
id: IEV:0002055
name: Positive regulation of G alpha i GDP-GTP exchange signaling
is_a: IEV:0002047 ! Positive regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0002048 ! Regulation of G alpha i GDP-GTP exchange signaling

[Term]
id: IEV:0002056
name: Positive regulation of G alpha q GDP-GTP exchange signaling
is_a: IEV:0002047 ! Positive regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0002049 ! Regulation of G alpha q GDP-GTP exchange signaling

[Term]
id: IEV:0002057
name: Positive regulation of G alpha s GDP-GTP exchange signaling
is_a: IEV:0002045 ! Regulation of G alpha s GDP-GTP exchange signaling
is_a: IEV:0002047 ! Positive regulation of G alpha GDP-GTP exchange signaling

[Term]
id: IEV:0002058
name: Positive regulation of G alpha t GDP-GTP exchange signaling
is_a: IEV:0002047 ! Positive regulation of G alpha GDP-GTP exchange signaling
is_a: IEV:0002050 ! Regulation of G alpha t GDP-GTP exchange signaling

[Term]
id: IEV:0002059
name: Negative regulation of (GDP-GTP exchange of G alpha)
is_a: IEV:0002046 ! Negative regulation of G alpha GDP-GTP exchange signaling

[Term]
id: IEV:0002060
name: Negative regulation of (GDP-GTP exchange of G alpha i)
is_a: IEV:0002051 ! Negative regulation of G alpha i GDP-GTP exchange