tag:www.inoh.org,2010:/inohblog/main/2 2010-06-16T08:42:39Z Integrating Network Objects with Hierarchies Movable Type 3.2-ja-2 tag:www.inoh.org,2010:/inohblog/main//2.55 2010-06-14T07:15:37Z 2010-06-16T08:42:39Z

The latest Event Ontology is Ver.1.71 Event Ontology is an ontology of pathways. It classifies pathways, sub-pathways and other biological phenomena to form a DAG structure. You can browse or search this ontology at INOH Ontology Viewer and download it...

Noriko Sakai INOH Ontology Viewer and download it from the OBO site and from our download page. Statistics ========== All entries 3775 Obsoletes 149 definition 652 GO IDs 516 KEGG Reaction IDs 596 KEGG map IDs 1179 Reactome IDs 110 PSI-MI IDs 70]]> Event Ontology Release Notes ===================== Version: 1.71 (14th Jun, 2010) Event Ontology is an ontology that organizes the concepts and terms of pathway objects such as sub-pathways, biological processes and experimental environments appearing in the cellular pathway (e.g. signal transductions, disease pathways, metabolic pathways, etc.) The concepts in the Event Ontology were manually extracted from scientific articles and text books. Each concept has a link to Gene Ontology if possible. Changes from version 1.70 ===================== 1. add the terms related to PDGF signaling pathway. 2. link the KEGG Reaction ID to the terms related to Metabolic pathway. 3. etc. More information about Event Ontology --------------------- Tatsuya Kushida, Toshihisa Takagi and Ken Ichiro Fukuda, Event Ontology: A Pathway-Centric Ontology for Biological Processes. Pacific Symposium on Biocomputing 11:152-163(2006). Statistics ========== All entries 3775 Obsoletes 149 definition 652 GO IDs 516 KEGG Reaction IDs 596 KEGG map IDs 1179 Reactome IDs 110 PSI-MI IDs 70 tag:www.inoh.org,2010:/inohblog/main//2.54 2010-06-03T06:50:46Z 2010-06-03T07:02:43Z

The data files are available from our download site. Signal Transduction Pathway Data and Metabolic Pathway Data. ====================== newly curated pathways ====================== Hedgehog signaling pathway Mammal D.melanogaster Canonical Insulin signaling pathway Mammal D.melanogaster C.elegans Canonical Jak-STAT signaling pathway D.melanogaster EGF...

Hiromi Nakamura Signal Transduction Pathway Data and Metabolic Pathway Data. ====================== newly curated pathways ====================== Hedgehog signaling pathway Mammal D.melanogaster Canonical Insulin signaling pathway Mammal D.melanogaster C.elegans Canonical Jak-STAT signaling pathway D.melanogaster EGF signaling pathway D.melanogaster C.elegans FGF signaling pathway Mouse Xenopus D.melanogaster C.elegans IGF signaling pathway Canonical IL-5 signaling(JAK1 JAK2 STAT1 STAT5) Canonical IL-13 signaling(JAK1 TYK2 STAT6) Canonical IL-23 signaling(JAK2 TYK2 STAT3 STAT4) Canonical ====================== Metabolic pathways ====================== Alanine_Aspartate_Asparagine_metabolism Aminosugars_metabolism Arginine_Proline_metabolism Butanoate_metabolism Citrate_cycle Folate_metabolism Fructose_Mannose_metabolism Galactose_metabolism Glutamate_Glutamine_metabolism Glycine_Serine_metabolism Glycolysis_Gluconeogenesis Histidine_degradation Inositol_phosphate_metabolism Lysine_degradation Methionine_Cysteine_metabolism Nicotinate_Nicotinamide_metabolism Pentose_phosphate_cycle Phenylalanine_degradation Porphyrin_metabolism Propanoate_metabolism Prostaglandin_Leukotriene_metabolism Purine_nucleotides_nucleosides_metabolism Pyrimidine_nucleotides_nucleosides_metabolism Pyruvate_metabolism Steroids_metabolism Tryptophan_degradation Tyrosine_metabolism Valine_Leucine_Isoleucine_degradation Vitamin_B6_metabolism ================= updated pathways ================= B cell receptor signaling BMP2 signaling(TGF-beta_signaling MolecularVariation) BMP2 signaling(through TAK1) CD4 T cell receptor signaling (JNK cascade) CD4 T cell receptor signaling (NF-kB cascade) CD4 T cell receptor signaling (ERK cascade) CD4 T cell receptor signaling Drosophila IMD pathway Drosophila Toll-like receptor signaling EGF signaling pathway EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) Fas signaling pathway FGF signaling pathway GPCR Adenosine A2A receptor signaling GPCR Dopamine D1like receptor GPCR GroupI metabotropic glutamate receptor GPCR signaling (G alpha i) GPCR signaling (G alpha q) GPCR signaling (G alpha s, Epac and ERK) GPCR signaling (G alpha s, PKA and ERK) GPCR signaling (cholera toxin) GPCR signaling (pertussis toxin) Growth hormone signaling(JAK2 STAT5) HGF signaling pathway IFN alpha signaling IFN gamma signaling(JAK1 JAK2 STAT1) IL-10 signaling(JAK1 TYK2 STAT3) IL-12 signaling(JAK2 TYK2 STAT4) IL-1 signaling pathway (through JNK cascade) IL-1 signaling pathway (through NF-kappaB) IL-1 signaling pathway (through p38 cascade) IL-2 signaling(JAK1 JAK3 STAT5) IL-3 signaling(JAK1 JAK2 STAT5) IL-4 signaling(JAK1 JAK3 STAT6) IL-6 signaling(JAK1 JAK2 STAT3) IL-7 signaling(JAK1 JAK3 STAT5) Integrin signaling pathway JAK STAT MolecularVariation 1 JAK STAT MolecularVariation 2 JAK-STAT pathway and regulation pathway LIF signaling(JAK1 JAK2 STAT3) NGF signaling pathway Notch signaling pathway Diagram PDGF signaling pathway TGF-beta signaling(through TAK1) TGF-beta_super_family_signaling_pathway(canonical) Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, JNK cascade) Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, p38 cascade) Toll-like receptor signaling pathway (through JNK cascade) Toll-like receptor signaling pathway (p38 cascade) Toll-like receptor signaling pathway (trough NF-kappaB) TNFR1 signaling pathway TPO signaling (JAK2 STAT3) VEGF signaling pathway C. elegans endoderm induction Wnt signaling pathway Diagram Canonical Wnt signaling pathway Diagram Drosophila Wingless/Wnt signaling pathway Diagram Mammalian Wnt signaling pathway Diagram Xenopus axis formation Wnt signaling pathway Diagram ]]> ========================= BioPAX Level2 Statistics ========================= pathway 755 pathwayStep 3560 control 144 catalysis 2517 modulation 0 conversion 192 biochemicalReaction 1634 transportWithBiochemicalReaction 0 complexAssembly 970 transport 203 complex 5005 dna 575 protein 13041 rna 169 smallMolecule 4265 physicalEntityParticipant 9534 sequenceParticipant 13788 =============== INOH Statistics =============== -- NODE -- Diagram 101 EventCompound 3655 Event 99 Process 2999 EventRelation 443 Protein 13041 MolecularComplexCompound 4726 MolecularComplex 45 DNACompound 234 DNA 575 ChemicalSubstance 4265 RNA 169 Terminal 32 -- EDGE -- IN 5470 OUT 4663 Control 144 Catalyze 2517 Connected 3427 PASSING 3013 HomologousEvent 269 MolecularVariation 240 Identical 50 tag:www.inoh.org,2010:/inohblog/main//2.53 2010-06-01T06:23:16Z 2010-06-03T05:03:42Z

The latest MoleculeRole Ontology is Ver2.23 MoleculeRole Ontology is an ontology for proteins/chemicals. It is used to annotate protein family names, generic/concrete protein names and chemical names in the INOH pathway data. You can browse or search this ontology at...

Satoko Yamamoto INOH Ontology Viewer and download it from the OBO site and from our download page. Statistics ========== All entries 9132 Chemicals 593 Proteins 8538 Definition 250 UniProt ACs 5823 GO IDs 347 InterPro ACs 32 KEGG COMPOUND IDs 588 PubMed IDs 160]]> http://www3.interscience.wiley.com/cgi-bin/fulltext/109860932/HTMLSTART) Statistics ========== All entries 9132 Chemicals 593 Proteins 8538 Definition 250 UniProt ACs 5823 GO IDs 347 InterPro ACs 32 KEGG COMPOUND IDs 588 PubMed IDs 160]]> tag:www.inoh.org,2010:/inohblog/main//2.52 2010-06-01T06:22:17Z 2010-06-04T03:59:42Z

The latest Event Ontology is Ver.1.70 Event Ontology is an ontology of pathways. It classifies pathways, sub-pathways and other biological phenomena to form a DAG structure. You can browse or search this ontology at INOH Ontology Viewer and download it...

Noriko Sakai INOH Ontology Viewer and download it from the OBO site and from our download page. Statistics ========== All entries 3756 Obsoletes 149 definition 653 GO IDs 516 KEGG IDs 825 Reactome IDs 110 PSI-MI IDs 70]]> Event Ontology Release Notes ===================== Version: 1.70 (28th Apr, 2010) Event Ontology is an ontology that organizes the concepts and terms of pathway objects such as sub-pathways, biological processes and experimental environments appearing in the cellular pathway (e.g. signal transductions, disease pathways, metabolic pathways, etc.) The concepts in the Event Ontology were manually extracted from scientific articles and text books. Each concept has a link to Gene Ontology if possible. Changes from version 1.62 ===================== 1. add the terms related to IGF signaling pathway, EGF signaling pathway, FGF signaling pathway, insulin signaling pathway, Hedgehog signaling pathway and metabolic pathway. 2. add the location where events take place to the terms for "moleculer interaction". 3. add three new relationship types --regulates, negatively_regulates and positively_regulates. 4. remove the terms for the annotation of events whose biological process is unknown. 5. etc. More information about Event Ontology --------------------- Tatsuya Kushida, Toshihisa Takagi and Ken Ichiro Fukuda, Event Ontology: A Pathway-Centric Ontology for Biological Processes. Pacific Symposium on Biocomputing 11:152-163(2006). Statistics ========== All entries 3756 Obsoletes 149 definition 653 GO IDs 516 KEGG IDs 825 Reactome IDs 110 PSI-MI IDs 70 tag:www.inoh.org,2010:/inohblog/main//2.56 2010-06-01T06:20:51Z 2010-06-22T06:58:45Z

The latest Location Ontology is Ver.1.01 Location Ontology is an ontology of cellular location. You can browse or search this ontology at INOH Ontology Viewer and download it from our download page. Statistics ========== all entries 52 obsolete 2 definition...

Noriko Sakai INOH Ontology Viewer and download it from our download page. Statistics ========== all entries 52 obsolete 2 definition 44 GO IDs 49]]> Location Ontology Release Notes ===================== Version: 1.01 (28th Apr, 2010) Changes from version 1.00 ===================== add the terms related to cilium. Statistics ========== all entries 52 obsolete 2 definition 44 GO IDs 49 tag:www.inoh.org,2010:/inohblog/main//2.51 2010-04-28T06:07:03Z 2010-04-28T06:14:46Z

Our new INOH Client is now available. Windows, Max OSX and Linux are supported. JRE 6.0 is required. You can download INOH client application from here. The version number is updated from 2.2.2 to 3.1.9....

Hiromi Nakamura here. The version number is updated from 2.2.2 to 3.1.9.]]> Release Notes ====================== Version 3.1.9 Newly added features: - added "Font" , specify the default font in "Tool --> Settings". - added "Organism" , specify the default value of Organism property in "Tool --> Settings". - added "Change node type" and "Change edge type" in "Object". - added "Overview Area" and "Magnifier View Area". The Overview Area is placed on the top right side of the screen. Overview of the diagram you are currently editing is displayed in this area. The Magnifier View Area is placed on the bottom right side of the screen. Magnified view of the diagram you are currently editing is displayed in this area. - added "Reduced View Mode". The reduced view that focused on molecular transition in the normal view, and these modes can be easily switched back and forth. tag:www.inoh.org,2010:/inohblog/main//2.50 2010-04-09T03:25:58Z 2010-04-09T04:48:10Z

Bug fix in "MatID"(ID of INOH). ID of objects that have the same biological identity was not equal. Update "MatID" of objects. The data files are available from our download site. As soon as we release INOH pathway data 3.0....

Hiromi Nakamura site. As soon as we release INOH pathway data 3.0.]]> tag:www.inoh.org,2009:/inohblog/main//2.49 2009-05-14T07:39:47Z 2009-05-14T07:53:26Z

Our new INOH Client is now available. Windows, Max OSX and Linux are supported. JRE 6.0 is required. You can download INOH client application from here. The version number is updated from 2.0.2 to 2.2.2....

Hiromi Nakamura here. The version number is updated from 2.0.2 to 2.2.2.]]> Release Notes ====================== Version 2.2.2 JRE 6 is required. Newly added features: - supported Mac OSX. - bug fix in "Ontology viewer links". - bug fix in "Check error". - ServerURI changed. http://www.inoh.org/axis/services/InohWebService --> http://www.inoh.org/axis2/services/InohWebService2 tag:www.inoh.org,2009:/inohblog/main//2.48 2009-05-14T07:27:02Z 2009-05-14T07:38:27Z

INOH database system reopened now. We are sorry for the inconvenience. "Keyword Search" and "Pathway retrieval Search" services of INOH client require client upgrade. You can download INOH client application from here. And JRE 6 is required. INOH client supports...

Hiromi Nakamura here. And JRE 6 is required. INOH client supports Windows, Mac OSX and Linux.]]> tag:www.inoh.org,2009:/inohblog/main//2.47 2009-01-07T04:16:20Z 2009-01-07T06:08:24Z

"Pathway retrieval Search" service of INOH client stops for system renewal now. We are sorry for inconvenience, and thanks your cooperation....

Hiromi Nakamura "Pathway retrieval Search" service of INOH client stops for system renewal now. We are sorry for inconvenience, and thanks your cooperation. tag:www.inoh.org,2008:/inohblog/main//2.46 2008-02-04T09:48:46Z 2008-02-04T09:59:06Z

INOH client 2.0.2 does not officially support Mac OSX because some of its features require Java 6, which has not been made available from Apple yet. But if you only do browsing then you can use the linux version on...

Ken Fukuda INOH client 2.0.2 does not officially support Mac OSX because some of its features require Java 6, which has not been made available from Apple yet. But if you only do browsing then you can use the linux version on your mac. See detailes in the "more" section bellow. INOH client is a pathway editor and a front end of our database and Java 6 is required to issue a query. But you can install the linux version on your Mac and browse pathways. 1. download Linux without Java VM from http://www.inoh.org/Web_Installers/install.htm 2. run the downloaded installer by # sh install.bin 4. cd to InohClient and edit the inoh.sh script in the bin-sample a) edit the following two variables. JAVA_HOME=... INOH_CLIENT_HOME=... b)edit the last line's ${JRE_HOME}/bin/java to fit your machine configuration. 5. start the INOH Client with # sh inoh.sh The pathway files (with .inoh extensions) are available from http://www.inoh.org/download.html#PathwayData tag:www.inoh.org,2007:/inohblog/main//2.44 2007-12-03T08:22:21Z 2009-05-14T08:21:09Z

Our new INOH Client is now available. Currently only Windows and Linux are supported. Mac OSX will be supported as soon as Apple releases Java 6 for Leopard. You can download the application from here. This version is a major...

Ken Fukuda here. This version is a major update and the version number is updated from 1.0.6 to 2.0.2. ===IMPORTANT!!!=== delete the "frame.layout" file in the .inoh directory of your home (e.g. Windows:C:\Documents and Settings\user-name,Linux:/home/user-name) before installing version 2.x. If not, panel pane will not appear correctly in your client. ]]> Release Notes ====================== Version 2.0.2 - Version 2 requires JRE1.6. Newly added features: - add "INOHID" and "secondaryINOHID" property. - add "External DB links Panel"(link to INOH Ontology Viewer,PubMed,UniProt,GO,and KEGG). - add "Errors Panel". -->check edge rules (ex.Catalyze edge : From Material To Process, Connected edge:between Proteins) -->check mandatory attributes. -->check attribute values and formats for CVs(ex."Organism","Citaion" of Evidence). -->check if two sequential events share the output and input entities correctly. - add edge redrawing (you do not have to delete and create a new edge to modify an existing edge) - add "Redo". - add "zoom selected" checkbox (local search and Errors panel). - change node double-click action. double-click a node object and a property edit dialog will pop-up. --> in version 1.x, double-click was yFiles' default action (get one level down of the graph hierarchy) tag:www.inoh.org,2007:/inohblog/main//2.43 2007-11-30T07:07:44Z 2007-11-30T07:25:50Z

The data files are available from our download site. ====================== newly curated pathways ====================== EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) Fas signaling pathway GPCR Adenosine A2A receptor signaling pathway TNFR1 signaling pathway ================= updated pathways ================= BMP2 signaling(through TAK1) BMP2...

Ken Fukuda site. ====================== newly curated pathways ====================== EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) Fas signaling pathway GPCR Adenosine A2A receptor signaling pathway TNFR1 signaling pathway ================= updated pathways ================= BMP2 signaling(through TAK1) BMP2 signaling(TGF-beta_signaling MolecularVariation) B cell receptor signaling CD4 T cell receptor signaling (JNK cascade) CD4 T cell receptor signaling (NF-kB cascade) CD4 T cell receptor signaling Drosophila IMD pathway Drosophila Toll-like receptor signaling EGF signaling pathway FGF signaling pathway GPCR Dopamine D1like receptor signaling pathway GPCR GroupI metabotropic glutamate receptor signaling pathway GPCR signaling (cholera toxin) GPCR signaling (G alpha i) GPCR signaling (G alpha q) GPCR signaling (G alpha s, Epac and ERK) GPCR signaling (G alpha s, PKA and ERK) GPCR signaling (pertussis toxin) Growth hormone signaling(JAK2 STAT5) HGF signaling pathway IFN gamma signaling(JAK1 JAK2 STAT1) IL-10 signaling(JAK1 TYK2 STAT3) Integrin signaling pathway JAK STAT MolecularVariation 1 JAK STAT MolecularVariation 2 JAK-STAT pathway and regulation pathway LIF signaling(JAK1 JAK2 STAT3) NGF signaling pathway TGF-beta signaling(through TAK1) TGF-beta_super_family_signaling_pathway(canonical) Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, JNK cascade) Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, p38 cascade) Toll-like receptor signaling pathway (through JNK cascade) Toll-like receptor signaling pathway (trough NF-kappaB) Toll-like receptor signaling pathway (p38 cascade) TPO signaling(JAK2 STAT3) VEGF signaling pathway C. elegans endoderm induction Wnt signaling pathway Diagram Canonical Wnt signaling pathway Diagram Drosophila Wingless/Wnt signaling pathway Diagram Mammalian Wnt signaling pathway Diagram Xenopus axis formation Wnt signaling pathway Diagram ]]> here. INOHID starts with P/I/M followed by an integer. Each letter ("P"/"I"/"M") stands for a pathway object, interaction, physicalEntity respectively. =================== BioPAX Level2 enhancement =================== Based on the UriCvNamespace Proposal for BioPAX Level2, the BioPAX main file loads an extension ontology to add properties not available in Level2. (further documentation : INOH worked examples for this proposal) added new property pathway -MOLECULAR-VARIATION -> pathway,pathwayStep added new property pathway -HOMOLOGOUS-EVENT -> pathway,pathwayStep added new property pathwayStep -MOLECULAR-VARIATION -> pathway,pathwayStep added new property pathwayStep -HOMOLOGOUS-EVENT -> pathway,pathwayStep added new property control -CONTROLLER-EVENT -> pathway,pathwayStep added new property control -CONTROLLED-EVENT -> pathway,pathwayStep added new property physicalEntityParticipant -GENERIC-EVIDENCE -> evidence added new property physicalEntityParticipant -LOCATIONONTOLOGY-EVIDENCE -> evidence added new property sequenceFeature -SEQUENCE-FEATURE-EVIDENCE -> evidence ========================= BioPAX Level2 Statistics ========================= pathway 363 pathwayStep 1849 control 107 catalysis 527 modulation 0 conversion 131 biochemicalReaction 538 transportWithBiochemicalReaction 0 complexAssembly 756 transport 141 complex 2633 dna 386 protein 5428 rna 77 smallMolecule 255 physicalEntityParticipant 4338 sequenceParticipant 9170 =============== INOH Statistics =============== -- NODE -- Diagram 62 EventCompound 1853 Event 76 Process 1566 EventRelation 323 Protein 8660 MolecularComplexCompound 3576 MolecularComplex 41 DNACompound 163 DNA 416 ChemicalSubstance 374 RNA 94 Terminal 31 -- EDGE -- IN 2741 OUT 2088 Control 107 Catalyze 527 Connected 2689 PASSING 1440 HomologousEvent 186 MolecularVariation 191 Identical 11 ]]> tag:www.inoh.org,2007:/inohblog/main//2.42 2007-10-25T01:47:52Z 2007-11-01T06:05:49Z

Paxtools persistency layer for BioPAX Level 2 specification is available from the BioPAX sourceforge CVS. Paxtools is a Domain Object Model(DOM) for BioPAX, providing software tools such as editors, exporters, importers, visualization tools and analysis algorithms with an API for...

Ken Fukuda BioPAX sourceforge CVS. Paxtools is a Domain Object Model(DOM) for BioPAX, providing software tools such as editors, exporters, importers, visualization tools and analysis algorithms with an API for manipulating BioPAX models. The Paxtools core model is developed at CBIO, MSKCC and the persistency layer is developed by INOH database. #NOTE: Currently we only have a "dev" version in the CVS. [documents] Find out here how to set up your Paxtools with a backbone DBMS. The javadoc for the Paxtools Level2 persistency layer API is available here. You can also get the pdf file of the paxtools poster abstract at ISMB 2007 here.]]> Paxtools provides a complete domain object model (DOM) in Java that enables users manipulating and evaluating BioPAX. It also provides state-of-the-art persistence services based on Java Persistence API. Finally Paxtools implement a fail-fast validation framework, mitigating the cost of potential pitfalls for the developers. Paxtools was designed to be modular, lightweight and platform independent to be easily embedded into applications. [quoted from the ISMB2007 poster abstract]]]> tag:www.inoh.org,2007:/inohblog/main//2.41 2007-10-03T08:44:41Z 2007-10-03T08:52:59Z

The latest MoleculeRole Ontology is Ver2.22 MoleculeRole Ontology is an ontology for proteins. You can download it from the OBO site and from our download page. Statistics ========== All entries 8821 Chemicals 592 Proteins 8228 Obsoletes 25 UniProt ACs 5572...

Satoko Yamamoto OBO site and from our download page. Statistics ========== All entries 8821 Chemicals 592 Proteins 8228 Obsoletes 25 UniProt ACs 5572 GO IDs 344 InterPro ACs 32 KEGG COMPOUND IDs 587 PubMed IDs 99]]> MoleculeRole Ontology Release Notes ===================== Version: 2.22 (Oct 3, 2007) Molecule Role is a hierarchical ontology which contains the molecular functional group names, the abstract molecule names and the concrete molecule names collected from literature manually. This classification is based on a conceptual classification of molecular roles in protein interaction and signal transduction. Changes from version 2.1x ===================== KEGG metabolic pathway related molecules (500~ chemicals and 300~ proteins) were added. Changes from version 2.0x ===================== Over 13,000 synonyms were added from EntrezGene, HGNC, FlyBase, OMIM, MGI and RGD database in an automatic way, using UniProt ACs manually collected in Molecule Role. Changes from version 1.xx ===================== The ontologies and definitions are provided together in a single OBO format flat file. This data is NOT also available in the GO flat file format as an ontology file and a definitions file. Protein sequences (=UniProt ACs) in the DbXrefs of protein leaf-class entries have been separated as new protein leaf-class entries. The parents-children relationship type is "sequence_of". The relationships of "Concrete-Names (e.g. ERK1)" and protein sequences (e.g. P27361) have been defined explicitly. More information about MoleculeRole Ontology --------------------- Satoko Yamamoto, Takao Asanuma, Toshihisa Takagi, Ken Ichiro Fukuda. The Molecule Role Ontology: an ontology for annotation of signal transduction pathway molecules in the scientific literature. Comparative and Functional Genomics 2004 Volume 5, Issue 6-7, p 528-536. (http://www3.interscience.wiley.com/cgi-bin/fulltext/109860932/HTMLSTART) Statistics ========== All entries 8821 Chemicals 592 Proteins 8228 Obsoletes 25 UniProt ACs 5572 GO IDs 344 InterPro ACs 32 KEGG COMPOUND IDs 587 PubMed IDs 99