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Ontology Data Download

The INOH Ontologies are freely available to the public. The INOH project team gives permission for INOH ontologies to be used without license for any purpose under three conditions:

  1. That the INOH project is clearly acknowledged as the source of the product;
  2. That any INOH Ontology file(s) displayed publically include the version number(s) and/or date(s) of it;
  3. That neither the content of a INOH file(s) nor the logical relationships embedded within the INOH file(s) be altered in any way.

Please address any questions about this policy to

EmailAddress

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Use OBO-Edit ( by GeneOntology ) to open these files.

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MoleculeRole Ontology
The URL of the latest version is this.
Below is the archive of ziped ontology file.
VersionFileSizeDate
new! 2.22595 KB07/10/03
2.21564 KB07/03/28
2.20554 KB06/11/01
2.11469 KB06/03/17
2.10448 KB06/01/31
MoleculeRole Ontology is a hierarchical ontology which contains the molecular functional group names, the abstract molecule names and the concrete molecule names collected from literature manually. This classification is based on a conceptual classification of molecular roles in protein interaction and signal transduction.

Event Ontology
The URL of the latest version is this.
Below is the archive of ziped ontology file.
VersionFileSizeDate
new! 1.6299 KB07/10/03
1.6195 KB07/03/28
1.6081 KB06/08/23
1.5978 KB06/02/08
1.5875 KB06/01/31
Event Ontology is an ontology that organizes the concepts and terms of pathway objects such as sub-pathways, biological processes and experimental environments appearing in the cellular pathway (e.g. signal transductions, disease pathways, metabolic pathways, etc.) The concepts in the Event Ontology were manually extracted from scientific articles and text books. Each concept has a link to Gene Ontology if possible.

Location Ontology
The URL of the latest version is this.
Below is the archive of ziped ontology file.
VersionFileSizeDate
new! 1.006 KB06/01/31
Location ontology is composed of the term that shows the localization of the molecule related to the process in the cell, and the term that composes is used for annotations of a protein and a molecular complex, etc. with the location ontology. Each term have been linked with Gene Ontology.

Pathway Data Download  (last update 2007.11.28)

There are 62 PathwayData files now.

Download All(INOH format) : zip ( 2.2 MB )  / tar.gz ( 2.1 MB )  / lzh ( 2.0 MB )
Download All(BioPAX level2 format) : zip ( 1.6 MB )  / tar.gz ( 1.6 MB )  / lzh ( 1.5 MB )

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Use INOH Client tool to open INOH format files.

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Download "Correspondence table of MatID and INOHID" : zip ( 23 KB )

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FileNameINOH formatBioPAX level2 format
PubMed
BMP2 signaling(through TAK1) 21KB 14KB
10748100, 11784015, 12700180, 14687659, 16644098, 16854512, 16949582, 8663074, 9878061
BMP2 signaling(TGF-beta_signaling MolecularVariation) 34KB 24KB
10205054, 10232991, 10775259, 10857556, 11057902, 11752591, 11752631, 11784015, 12040185, 14687659, 15705894, 15794126
B cell receptor signaling 42KB 36KB
11672421, 11752597, 11973130, 12461567, 14632637, 15023366, 15125833, 15219998, 15220003, 15221855, 15343367, 15541651, 16356853, 16356855, 17098202, 17468049, 7499357
CD4 T cell receptor signaling (ERK cascade) 27KB 22KB
10781399, 11672421, 11752597, 11752630, 11781344, 12040176, 12461567, 15023366, 15219998, 15220003, 15221855, 15343367, 15541651
CD4 T cell receptor signaling (JNK cascade) 33KB 27KB
10395678, 10714681, 10781399, 11094261, 11672421, 11752597, 11752630, 11781344, 12040176, 12461567, 14647476, 15023366, 15219998, 15343367, 17098202, 7546397, 8576157, 9794241
CD4 T cell receptor signaling (NF-kB cascade) 50KB 38KB
10781399, 11406365, 11672421, 11752597, 11752630, 11781344, 11973130, 12040176, 12461567, 14647476, 15023366, 15125833, 15219998, 15343367, 16356853, 16356856, 17098202, 17468049, 8871351
CD4 T cell receptor signaling 74KB 54KB
10395678, 10714681, 10781399, 11094261, 11406365, 11672421, 11752597, 11752630, 11781344, 11973130, 12040176, 12461567, 14647476, 15023366, 15125833, 15219998, 15220003, 15221855, 15343367, 15541651, 16356853, 16356856, 17098202, 17468049, 7546397, 8576157, 8871351, 9794241
Drosophila IMD pathway 49KB 29KB
10048301, 10409696, 10934188, 11018014, 11269501, 11402332, 11790549, 11812988, 12433364, 12464174, 12495727, 12614458, 12732719, 14519762, 14603309, 14698226, 14751763, 15037551, 15252032, 15476918, 15653304, 15708304, 15760446, 15797509, 15826489, 16497588, 16716487, 16763552, 9388784
Drosophila Toll-like receptor signaling 72KB 46KB
10409696, 11007948, 11447260, 11812988, 11934858, 12351681, 12446795, 12495727, 12614458, 12872120, 14603309, 14751763, 15476918, 15653304, 15708304, 15795223, 15797509, 15826489, 16924255
EGF signaling pathway 21KB 16KB
15110798
EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) 45KB 33KB
10379911, 10857556, 11932384, 12039028, 12040185, 14564341, 15123689, 15125881, 15561601, 15705894, 15752978, 15753310, 15996891, 16303314, 16868550, 9287210, 9794243
Fas signaling pathway 30KB 19KB
15071501, 16200196, 16406523
FGF signaling pathway 25KB 20KB
11353842, 11399424, 15282562, 15689573, 16216232, 17384583
GPCR Adenosine A2A receptor signaling pathway 23KB 19KB
11752597, 11804588, 12834807, 14734786, 15023366, 15521361, 7814360, 8321321, 9247123
GPCR Dopamine D1like receptor signaling pathway 23KB 18KB
10433257, 10604473, 11050161, 12834807, 14734786, 15023366, 15521361
GPCR GroupI metabotropic glutamate receptor signaling pathway 19KB 16KB
10341237, 10707049, 11672421, 11752597, 12461567, 14734786, 15023366, 15219998, 15343367, 16574233, 17376402, 7499357, 8321321
GPCR signaling (cholera toxin) 20KB 25KB
10895075, 11604548, 11752622, 12834807, 14619951, 14734786, 14762218, 15023366, 15521361, 7814360, 8834454
GPCR signaling (G alpha i) 15KB 21KB
11604548, 14734786, 14762218, 8774883
GPCR signaling (G alpha q) 21KB 26KB
10341237, 10707049, 11604548, 11672421, 11752597, 12461567, 14734786, 14762218, 15023366, 15219998, 15343367, 16574233, 17376402, 7499357, 8321321
GPCR signaling (G alpha s, Epac and ERK) 24KB 27KB
11604548, 11752597, 12834807, 14734786, 14762218, 17084085, 7814360, 8321321, 9247123, 9853756
GPCR signaling (G alpha s, PKA and ERK) 27KB 29KB
11604548, 11752597, 11804588, 12834807, 14734786, 14762218, 15023366, 15521361, 7814360, 8321321, 9247123
GPCR signaling (pertussis toxin) 17KB 22KB
11604548, 14734786, 14762218, 8774883, 9032437
Growth hormone signaling(JAK2 STAT5) 20KB 13KB
10379911, 11735235, 12040185, 14564341, 15125881, 15561601, 15996891, 16112592, 16868550
HGF signaling pathway 37KB 25KB
10871282, 11114738, 12791299, 14596869, 9922370
IFN alpha signaling(JAK1 TYK2 STAT1) 19KB 13KB
11932384, 12039028, 12040185, 14550502, 15541651, 15561601, 15753310, 16681834, 9287210
IFN alpha signaling(JAK1 TYK2 STAT1 STAT2) 265KB 18KB
11932384, 12039028, 12040185, 14550502, 15541651, 15561601, 15753310, 16681834, 9287210
IFN alpha signaling(JAK1 TYK2 STAT1 STAT3) 25KB 18KB
11932384, 12039028, 12040185, 14550502, 15389589, 15541651, 15561601, 15705894, 15753310, 16681834, 9287210
IFN alpha signaling(JAK1 TYK2 STAT3) 21KB 15KB
10857556, 12039028, 12040185, 14550502, 15389589, 15541651, 15561601, 15705894, 16681834, 9287210
IFN gamma signaling(JAK1 JAK2 STAT1) 27KB 17KB
11932384, 12039028, 12040185, 14550502, 15541651, 15561601, 15753310, 15850655, 16681834, 9287210
IL-10 signaling(JAK1 TYK2 STAT3) 30KB 18KB
10433356, 10851054, 10857556, 12039028, 12040185, 12626585, 15541651, 15561601, 15705894, 7543512, 9287210
IL-12 signaling(JAK2 TYK2 STAT4) 19KB 14KB
10415122, 12039028, 12040185, 12805384, 12948519, 15004198, 15541651, 15561601, 15722191, 9144409, 9287210
IL-1 signaling pathway (through JNK cascade) 53KB 35KB
10373513, 10854325, 11390361, 11460167, 12217523, 12242293, 12464174, 12620219, 12893815, 14665666, 9069263, 9261174
IL-1 signaling pathway (through NF-kappaB) 52KB 34KB
10373513, 10854325, 11460167, 12217523, 12242293, 12360211, 12464174, 12620219, 12893815, 9261174
IL-1 signaling pathway (through p38 cascade) 49KB 33KB
10373513, 10854325, 11274345, 11460167, 12217523, 12242293, 12464174, 12620219, 12893815, 14665666, 9261174
IL-2 signaling(JAK1 JAK3 STAT5) 20KB 15KB
10379911, 10808165, 10920190, 11750878, 12039028, 12040185, 14564341, 15125881, 15541651, 15561601, 15996891, 16750817, 16868550, 8700888, 9287210
IL-3 signaling(JAK1 JAK2 STAT5) 20KB 14KB
10379911, 12039028, 12040185, 14564341, 15125881, 15561601, 15996891, 16767694, 16868550, 9287210, 9794243
IL-4 signaling(JAK1 JAK3 STAT6) 20KB 14KB
12039028, 12040185, 12791978, 15464449, 15541651, 15561601, 16750817, 9287210
IL-6 signaling(JAK1 JAK2 STAT3) 23KB 16KB
10857556, 12039028, 12040185, 12773095, 15504351, 15561601, 15705894, 7772277, 9287210, 9716487
IL-7 signaling(JAK1 JAK3 STAT5) 28KB 25KB
10379911, 12039028, 12040185, 14564341, 15123689, 15125881, 15541651, 15561601, 15996891, 16303314, 16868550, 7662955, 9287210
Integrin signaling pathway 39KB 34KB
10354709, 10446041, 10809663, 12743027, 15179030, 9741627
JAK STAT MolecularVariation 1 136KB 84KB
10415122, 10433356, 10808165, 10851054, 10857556, 11735235, 11750878, 11750880, 12039028, 12040185, 12487370, 12626585, 12773095, 12791978, 12805384, 12948519, 14550502, 14564341, 15125881, 15464449, 15541651, 15561601, 15722191, 15752978, 15996891, 16112592, 16303314, 16322778, 16681834, 16750817, 16767694, 16868550, 8700888, 9287210, 9351438, 9716487, 9794243, 9974393
JAK STAT MolecularVariation 2 116KB 76KB
10379911, 10415122, 10433356, 10808165, 10851054, 10857556, 11750880, 11932384, 12039028, 12040185, 12626585, 12773095, 12791978, 12805384, 12948519, 14550502, 14564341, 15004198, 15125881, 15389589, 15464449, 15541651, 15561601, 15705894, 15722191, 15752978, 15753310, 15996891, 16112592, 16303314, 16322778, 16681834, 16750817, 16767694, 16868550, 8700888, 9144409, 9351438, 9716487, 9794243
JAK-STAT pathway and regulation pathway 49KB 43KB
10617656, 12039028, 12461567, 14607831, 15220003, 15221855, 15541651, 15561601, 15705894, 16750817, 9153303, 9974393
LIF signaling(JAK1 JAK2 STAT3) 28KB 19KB
10205054, 10232991, 10857556, 11752591, 12039028, 12040185, 12487370, 14687659, 15541651, 15561601, 15705894, 15794126, 16480448, 9287210, 9351438
NGF signaling pathway 22KB 17KB
10330161, 10506570, 11399424, 14641020, 15282562, 17384583
Notch signaling pathway Diagram 103KB 74KB
10221902, 10353900, 10882062, 10882063, 10940313, 11112321, 11585921, 11799064, 11818085, 12049766, 12464310, 12651094, 14670296, 14973298, 14986688, 15108805, 15288257, 15886115, 9244302, 9389650, 9653148
PDGF signaling pathway 21KB 15KB
15110798
TGF-beta signaling(through TAK1) 24KB 16KB
11752591, 11994497, 12359303, 12700180, 14534577, 14687659, 15733830, 16123807, 16260493, 16644098, 16824734, 16854512, 16949582, 8663074
TGF-beta_super_family_signaling_pathway(canonical) 36KB 27KB
11057902, 11163210, 11278251, 11389444, 11752591, 11752631
Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, JNK cascade) 32KB 22KB
10465784, 10854325, 11460167, 12217523, 12242293, 12360211, 12464174, 12620219, 12893815, 14609719, 14665666, 9069263
Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, p38 cascade) 32KB 22KB
10465784, 10854325, 11274345, 12217523, 12242293, 12360211, 12464174, 12620219, 12893815, 14609719, 14665666
Toll-like receptor signaling pathway (through JNK cascade) 46KB 31KB
10373513, 10854325, 11460167, 12217523, 12242293, 12360211, 12464174, 12620219, 12893815, 14609719, 14665666, 9069263, 9261174
Toll-like receptor signaling pathway (trough NF-kappaB) 48KB 32KB
10373513, 10854325, 11460167, 12217523, 12242293, 12360211, 12464174, 12620219, 12893815, 14609719, 14665666, 9261174
Toll-like receptor signaling pathway (p38 cascade) 46KB 30KB
10373513, 10854325, 11274345, 11460167, 12217523, 12242293, 12360211, 12464174, 12620219, 12893815, 14609719, 14665666, 9261174
TNFR1 signaling pathway 43KB 30KB
12655295, 15653317, 16200196, 16469705, 16537970
TPO signaling(JAK2 STAT3) 21KB 13KB
10857556, 11750880, 12040185, 15561601, 15705894, 16322778
VEGF signaling pathway 25KB 25KB
10744763, 11237210, 11369257, 12843393, 13678960, 14641020, 15134532, 15282562, 17384583, 9393975, 9804796, 9922370
C. elegans endoderm induction Wnt signaling pathway Diagram 64KB 48KB
10072378, 10073940, 10097073, 10201374, 10228155, 10380924, 10391247, 10421371, 10428961, 10488343, 10517632, 10603471, 10656974, 10684251, 10688669, 10693808, 10694878, 10769018, 10775268, 10882137, 10890911, 10898789, 10978892, 11029006, 11029007, 11029008, 11336703, 11452312, 11532957, 11742996, 11955446, 11988739, 12015286, 12050670, 12205098, 12210516, 12556497, 12581524, 12581525, 12636921, 12712206, 12717451, 12900447, 14636582, 14731402, 14755243, 15066285, 15166250, 15292219, 15473860, 2158444, 8666229, 8717036, 8824257, 8985181, 9096311, 9288750, 9554852, 9556553, 9601641, 9635432, 9783586
Canonical Wnt signaling pathway Diagram 49KB 38KB
10072378, 10073940, 10097073, 10201374, 10228155, 10380924, 10391247, 10421371, 10428961, 10488343, 10517632, 10656974, 10684251, 10688669, 10693808, 10694878, 10769018, 10775268, 10882137, 10890911, 10898789, 10978892, 11029006, 11029007, 11029008, 11336703, 11452312, 11532957, 11955446, 11988739, 12015286, 12050670, 12205098, 12556497, 12581524, 12581525, 12636921, 12712206, 12717451, 12900447, 14636582, 14731402, 14755243, 15066285, 15166250, 15292219, 15473860, 2158444, 8666229, 8717036, 8824257, 8985181, 9096311, 9288750, 9554852, 9556553, 9601641, 9635432, 9783586
Drosophila Wingless/Wnt signaling pathway Diagram 75KB 54KB
10072378, 10073940, 10097073, 10201374, 10228155, 10380924, 10391247, 10421371, 10428961, 10488343, 10517632, 10656974, 10684251, 10688669, 10693808, 10694878, 10769018, 10775268, 10882137, 10890911, 10898789, 10978892, 11029006, 11029007, 11029008, 11336703, 11452312, 11532957, 11955446, 11988739, 12015286, 12050670, 12205098, 12556497, 12581524, 12581525, 12636921, 12712206, 12717451, 12850443, 12900447, 14636582, 14731402, 14755243, 15066285, 15166250, 15292219, 15473860, 2158444, 8666229, 8717036, 8824257, 8985181, 9096311, 9288750, 9554852, 9556553, 9601641, 9635432, 9783586
Mammalian Wnt signaling pathway Diagram 97KB 66KB
10072378, 10073940, 10097073, 10201374, 10228155, 10380924, 10391247, 10421371, 10428961, 10488343, 10517632, 10656974, 10684251, 10688669, 10693808, 10694878, 10769018, 10775268, 10882137, 10890911, 10898789, 10978892, 11029006, 11029007, 11029008, 11336703, 11452312, 11532957, 11955446, 11988739, 12015286, 12050670, 12205098, 12556497, 12581524, 12581525, 12636921, 12712206, 12717451, 12900447, 14636582, 14731402, 14755243, 15066285, 15166250, 15292219, 15473860, 2158444, 8666229, 8717036, 8824257, 8985181, 9096311, 9288750, 9554852, 9556553, 9601641, 9635432, 9783586
Xenopus axis formation Wnt signaling pathway Diagram 85KB 59KB
10072378, 10073940, 10097073, 10201374, 10228155, 10380924, 10391247, 10421371, 10428961, 10488343, 10517632, 10656974, 10684251, 10688669, 10693808, 10694878, 10769018, 10775268, 10882137, 10890911, 10898789, 10978892, 11029006, 11029007, 11029008, 11336703, 11452312, 11532957, 11955446, 11988739, 12015286, 12050670, 12205098, 12556497, 12581524, 12581525, 12636921, 12712206, 12717451, 12900447, 14636582, 14731402, 14755243, 15066285, 15166250, 15292219, 15473860, 2158444, 8666229, 8717036, 8756721, 8824257, 8985181, 9096311, 9288750, 9308964, 9407023, 9554852, 9556553, 9601641, 9635432, 9783586, 9783587